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Conserved domains on  [gi|734858079|ref|WP_034108115|]
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MULTISPECIES: BrnA antitoxin family protein [Pseudomonas]

Protein Classification

BrnA antitoxin family protein( domain architecture ID 10007504)

BrnA antitoxin family protein similar to type II toxin-antitoxin system antitoxin BrnA that neutralizes the toxin BrnT

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3514 COG3514
Uncharacterized conserved protein, DUF4415 family [Function unknown];
1-77 2.96e-32

Uncharacterized conserved protein, DUF4415 family [Function unknown];


:

Pssm-ID: 442736  Cd Length: 91  Bit Score: 107.05  E-value: 2.96e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734858079  1 MTQTSKTDWERLAKMNDKEI------DTSDIPELDADFFRHAELRV-------PVKQAVTIRLDADVLEWFKGQGSGYQT 67
Cdd:COG3514   1 MSKKSKTDLKALTAEEDEEItaaaaiDPSDAPELTDEFFARARKRRrgrpkaaPPKVQVTIRLDPDVLEWFKATGPGWQT 80

                        90
                ....*....|
gi 734858079 68 RINQLLRQYM 77
Cdd:COG3514  81 RINAALRDYL 90
 
Name Accession Description Interval E-value
COG3514 COG3514
Uncharacterized conserved protein, DUF4415 family [Function unknown];
1-77 2.96e-32

Uncharacterized conserved protein, DUF4415 family [Function unknown];


Pssm-ID: 442736  Cd Length: 91  Bit Score: 107.05  E-value: 2.96e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734858079  1 MTQTSKTDWERLAKMNDKEI------DTSDIPELDADFFRHAELRV-------PVKQAVTIRLDADVLEWFKGQGSGYQT 67
Cdd:COG3514   1 MSKKSKTDLKALTAEEDEEItaaaaiDPSDAPELTDEFFARARKRRrgrpkaaPPKVQVTIRLDPDVLEWFKATGPGWQT 80

                        90
                ....*....|
gi 734858079 68 RINQLLRQYM 77
Cdd:COG3514  81 RINAALRDYL 90
BrnA_antitoxin pfam14384
BrnA antitoxin of type II toxin-antitoxin system; BrnA is family of antitoxins that ...
 24-77 5.20e-21

BrnA antitoxin of type II toxin-antitoxin system; BrnA is family of antitoxins that neutralizes the toxin BrnT, pfam04365. It consists of 3 alpha-helices and a C-terminal ribbon-helix-helix DNA binding domain. As in other toxin-antitoxin systems, BrnA negatively autoregulates the brnTA operon and has higher affinity for the DNA operator when complexed with BrnT. It dimerizes with two molecules of its toxin BrnT.


Pssm-ID: 433924  Cd Length: 67  Bit Score: 78.10  E-value: 5.20e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 734858079  24 DIPEL-DADFFRHAELRVPV------------KQAVTIRLDADVLEWFKGQGSGYQTRINQLLRQYM 77
Cdd:pfam14384  1 DAPELtDEQWLARARPAKEAlprgrprrplppKKAVTIRLDADVLEAFKATGKGWQTRMNAALREAL 67
 
Name Accession Description Interval E-value
COG3514 COG3514
Uncharacterized conserved protein, DUF4415 family [Function unknown];
1-77 2.96e-32

Uncharacterized conserved protein, DUF4415 family [Function unknown];


Pssm-ID: 442736  Cd Length: 91  Bit Score: 107.05  E-value: 2.96e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734858079  1 MTQTSKTDWERLAKMNDKEI------DTSDIPELDADFFRHAELRV-------PVKQAVTIRLDADVLEWFKGQGSGYQT 67
Cdd:COG3514   1 MSKKSKTDLKALTAEEDEEItaaaaiDPSDAPELTDEFFARARKRRrgrpkaaPPKVQVTIRLDPDVLEWFKATGPGWQT 80

                        90
                ....*....|
gi 734858079 68 RINQLLRQYM 77
Cdd:COG3514  81 RINAALRDYL 90
BrnA_antitoxin pfam14384
BrnA antitoxin of type II toxin-antitoxin system; BrnA is family of antitoxins that ...
 24-77 5.20e-21

BrnA antitoxin of type II toxin-antitoxin system; BrnA is family of antitoxins that neutralizes the toxin BrnT, pfam04365. It consists of 3 alpha-helices and a C-terminal ribbon-helix-helix DNA binding domain. As in other toxin-antitoxin systems, BrnA negatively autoregulates the brnTA operon and has higher affinity for the DNA operator when complexed with BrnT. It dimerizes with two molecules of its toxin BrnT.


Pssm-ID: 433924  Cd Length: 67  Bit Score: 78.10  E-value: 5.20e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 734858079  24 DIPEL-DADFFRHAELRVPV------------KQAVTIRLDADVLEWFKGQGSGYQTRINQLLRQYM 77
Cdd:pfam14384  1 DAPELtDEQWLARARPAKEAlprgrprrplppKKAVTIRLDADVLEAFKATGKGWQTRMNAALREAL 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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