|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05333 |
PRK05333 |
NAD-dependent protein deacetylase; |
17-299 |
0e+00 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 235415 Cd Length: 285 Bit Score: 543.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 17 ADVDPAALDALHTFVERHPRLLVLTGAGISTDSGIPGYRDRNGQWMRSPPIQLHEFLGSDAARRRYWARSMIGWPVVGRA 96
Cdd:PRK05333 2 PDADPAALDALQDFVERHPRLFVLTGAGISTDSGIPDYRDRNGQWKRSPPITYQAFMGSDAARRRYWARSMVGWPVFGRA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 97 RPNGSHVALARLGGAGRIERLVTQNVDGLHQRAGSDDVIELHGGINGVTCLDCGAHHARATIQTVLEADNPELLGAQAEP 176
Cdd:PRK05333 82 QPNAAHHALARLGAAGRIERLVTQNVDGLHQRAGSRDVIELHGRLDGVRCMGCGARHPRAEIQHVLEAANPEWLALEAAP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 177 AADGDAHLEWAALDTFRIPACPACGGLLKPAVVFFGENVPRERVALASQALDAADALLVVGSSLMVYSGYRFCVWAQAQH 256
Cdd:PRK05333 162 APDGDADLEWAAFDHFRVPACPACGGILKPDVVFFGENVPRERVAAARAALDAADAVLVVGSSLMVYSGYRFCVWAAQQG 241
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 736004541 257 KPLAALNLGHTRADPILTLKVEAHCAPALDALVARLGLGRSSA 299
Cdd:PRK05333 242 KPIAALNLGRTRADPLLTLKVEASCAQALAALVARLGLAGRDA 284
|
|
| SIRT4 |
cd01409 |
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and ... |
27-285 |
7.93e-131 |
|
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238700 Cd Length: 260 Bit Score: 372.40 E-value: 7.93e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 27 LHTFVERHPRLLVLTGAGISTDSGIPGYRDRNGQWMRSP-PIQLHEFLGSDAARRRYWARSMIGWPVVGRARPNGSHVAL 105
Cdd:cd01409 1 LQDFVARSRRLLVLTGAGISTESGIPDYRSEGGLYSRTFrPMTHQEFMRSPAARQRYWARSFVGWPRFSAAQPNAAHRAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 106 ARLGGAGRIERLVTQNVDGLHQRAGSDDVIELHGGINGVTCLDCGAHHARATIQTVLEADNPELLGAQAEPAADGDAHLE 185
Cdd:cd01409 81 AALEAAGRLHGLITQNVDGLHTKAGSRNVVELHGSLHRVVCLSCGFRTPRAELQDRLEALNPGFAEQAAGQAPDGDVDLE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 186 WAALDTFRIPACPACGGLLKPAVVFFGENVPRERVALASQALDAADALLVVGSSLMVYSGYRFCVWAQAQHKPLAALNLG 265
Cdd:cd01409 161 DEQVAGFRVPECERCGGVLKPDVVFFGENVPRDRVVTAAARLAEADALLVLGSSLMVYSGYRFVLAAAEAGLPIAIVNIG 240
|
250 260
....*....|....*....|
gi 736004541 266 HTRADPILTLKVEAHCAPAL 285
Cdd:cd01409 241 PTRADHLATLKVDARCGEVL 260
|
|
| SIR2 |
COG0846 |
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ... |
23-290 |
4.55e-69 |
|
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440607 Cd Length: 243 Bit Score: 214.64 E-value: 4.55e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 23 ALDALHTFVERHPRLLVLTGAGISTDSGIPGYRDRNGQWMRSPPIQL--HEFLGSDAAR--RRYWARsmigWPVVGRARP 98
Cdd:COG0846 3 KIERLAELLREAKRIVVLTGAGISAESGIPDFRGPDGLWEKYDPEEVasPEAFRRDPELvwAFYNER----RRLLRDAEP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 99 NGSHVALARLGGAGRIERLVTQNVDGLHQRAGSDDVIELHGGINGVTCLDCGAHHaratiqtvleaDNPELLgaqaepaa 178
Cdd:COG0846 79 NAAHRALAELEKAGKLVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGKRY-----------DLEDVL-------- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 179 dgdahlewAALDTFRIPACPACGGLLKPAVVFFGENVPRERVALASQALDAADALLVVGSSLMVYSGYRFCVWAQAQHKP 258
Cdd:COG0846 140 --------EDLEGELPPRCPKCGGLLRPDVVWFGEMLPEEALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKRAGAP 211
|
250 260 270
....*....|....*....|....*....|..
gi 736004541 259 LAALNLGHTRADPILTLKVEAHCAPALDALVA 290
Cdd:COG0846 212 LVEINPEPTPLDSLADLVIRGDAGEVLPALVE 243
|
|
| prot_deacyl_CobB |
NF040867 |
NAD-dependent protein deacetylase; |
37-292 |
1.26e-53 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 468804 Cd Length: 242 Bit Score: 175.07 E-value: 1.26e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 37 LLVLTGAGISTDSGIPGYRDRNGQWMRSPPIQLHEFLGSDAARRRYWARSMIGWPVVGRARPNGSHVALARLGGAGRIER 116
Cdd:NF040867 13 AIAFTGAGISTESGIPTFRGPDGLWRRYDPEELATIEAFERDPKLVWEFYRWRMEKLFDAKPNPAHYALAELERMGILKA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 117 LVTQNVDGLHQRAGSDDVIELHGGINGVTCLDCGA-HHARATIQTVLEADNPellgaqaepaadgdahlewaaldtfriP 195
Cdd:NF040867 93 VITQNVDGLHQRAGSRNVIELHGNMRRVRCTSCGRtYDLEEVLRKIDKGELP---------------------------P 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 196 ACPACGGLLKPAVVFFGENVP----RERVALASQaldaADALLVVGSSLMVYSGYRFCVWAQAQHKPLAALNLGHTRADP 271
Cdd:NF040867 146 RCPECGGLLRPDVVLFGEPLPddalEEAFELAER----SDVVLVVGSSLTVYPAAYLPYIAKENGGKLIIINPEETPLDP 221
|
250 260
....*....|....*....|.
gi 736004541 272 ILTLKVEAHCAPALDALVARL 292
Cdd:NF040867 222 IADIVLRGRAGEVLPKLVEEV 242
|
|
| SIR2 |
pfam02146 |
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ... |
42-244 |
7.13e-44 |
|
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i
Pssm-ID: 426621 Cd Length: 179 Bit Score: 147.78 E-value: 7.13e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 42 GAGISTDSGIPGYRDRNGQWMRSPPIQLH--EFLGSDAARRRY---WARSMIGWPVvGRARPNGSHVALARLGGAGRIER 116
Cdd:pfam02146 1 GAGISTESGIPDFRSDDGLYAKLAPEELAspEAFFSNPELVWDpepFYNIARELLP-GEAQPNPAHYFIAKLEDKGKLLR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 117 LVTQNVDGLHQRAGSDDVIELHGGINGVTCLDCgahHARATIQTVLEADNPEllgaqaepaadgdahlewaaldtfRIPA 196
Cdd:pfam02146 80 LITQNIDGLHERAGSKKVVELHGSFAKARCVSC---HQKYTGETLYERIRPE------------------------KVPH 132
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 736004541 197 CPACGGLLKPAVVFFGENVPrERVALASQALDAADALLVVGSSLMVYS 244
Cdd:pfam02146 133 CPQCGGLLKPDIVFFGENLP-DKFHRAYEDLEEADLLIVIGTSLKVYP 179
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05333 |
PRK05333 |
NAD-dependent protein deacetylase; |
17-299 |
0e+00 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 235415 Cd Length: 285 Bit Score: 543.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 17 ADVDPAALDALHTFVERHPRLLVLTGAGISTDSGIPGYRDRNGQWMRSPPIQLHEFLGSDAARRRYWARSMIGWPVVGRA 96
Cdd:PRK05333 2 PDADPAALDALQDFVERHPRLFVLTGAGISTDSGIPDYRDRNGQWKRSPPITYQAFMGSDAARRRYWARSMVGWPVFGRA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 97 RPNGSHVALARLGGAGRIERLVTQNVDGLHQRAGSDDVIELHGGINGVTCLDCGAHHARATIQTVLEADNPELLGAQAEP 176
Cdd:PRK05333 82 QPNAAHHALARLGAAGRIERLVTQNVDGLHQRAGSRDVIELHGRLDGVRCMGCGARHPRAEIQHVLEAANPEWLALEAAP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 177 AADGDAHLEWAALDTFRIPACPACGGLLKPAVVFFGENVPRERVALASQALDAADALLVVGSSLMVYSGYRFCVWAQAQH 256
Cdd:PRK05333 162 APDGDADLEWAAFDHFRVPACPACGGILKPDVVFFGENVPRERVAAARAALDAADAVLVVGSSLMVYSGYRFCVWAAQQG 241
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 736004541 257 KPLAALNLGHTRADPILTLKVEAHCAPALDALVARLGLGRSSA 299
Cdd:PRK05333 242 KPIAALNLGRTRADPLLTLKVEASCAQALAALVARLGLAGRDA 284
|
|
| SIRT4 |
cd01409 |
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and ... |
27-285 |
7.93e-131 |
|
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238700 Cd Length: 260 Bit Score: 372.40 E-value: 7.93e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 27 LHTFVERHPRLLVLTGAGISTDSGIPGYRDRNGQWMRSP-PIQLHEFLGSDAARRRYWARSMIGWPVVGRARPNGSHVAL 105
Cdd:cd01409 1 LQDFVARSRRLLVLTGAGISTESGIPDYRSEGGLYSRTFrPMTHQEFMRSPAARQRYWARSFVGWPRFSAAQPNAAHRAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 106 ARLGGAGRIERLVTQNVDGLHQRAGSDDVIELHGGINGVTCLDCGAHHARATIQTVLEADNPELLGAQAEPAADGDAHLE 185
Cdd:cd01409 81 AALEAAGRLHGLITQNVDGLHTKAGSRNVVELHGSLHRVVCLSCGFRTPRAELQDRLEALNPGFAEQAAGQAPDGDVDLE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 186 WAALDTFRIPACPACGGLLKPAVVFFGENVPRERVALASQALDAADALLVVGSSLMVYSGYRFCVWAQAQHKPLAALNLG 265
Cdd:cd01409 161 DEQVAGFRVPECERCGGVLKPDVVFFGENVPRDRVVTAAARLAEADALLVLGSSLMVYSGYRFVLAAAEAGLPIAIVNIG 240
|
250 260
....*....|....*....|
gi 736004541 266 HTRADPILTLKVEAHCAPAL 285
Cdd:cd01409 241 PTRADHLATLKVDARCGEVL 260
|
|
| SIR2-fam |
cd01407 |
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze ... |
36-277 |
2.59e-81 |
|
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer.
Pssm-ID: 238698 Cd Length: 218 Bit Score: 245.17 E-value: 2.59e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 36 RLLVLTGAGISTDSGIPGYRDRNGQWMRSPPiqlhEFLGSDAARRRYWARSMIGWPV----VGRARPNGSHVALARLGGA 111
Cdd:cd01407 2 RIVVLTGAGISTESGIPDFRSPGGLWARLDP----EELAFSPEAFRRDPELFWGFYRerryPLNAQPNPAHRALAELERK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 112 GRIERLVTQNVDGLHQRAGSDDVIELHGGINGVTCLDCGAHHARATIQtvleadnpellgaqaepaadgdahlewAALDT 191
Cdd:cd01407 78 GKLKRVITQNVDGLHQRAGSPKVIELHGSLFRVRCTKCGKEYPRDELQ---------------------------ADIDR 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 192 FRIPACPACGGLLKPAVVFFGENVPRERVALASQALDaADALLVVGSSLMVYSGYRFCVWAQAQHKPLAALNLGHTRADP 271
Cdd:cd01407 131 EEVPRCPKCGGLLRPDVVFFGESLPEELDEAAEALAK-ADLLLVIGTSLQVYPAAGLPLYAPERGAPVVIINLEPTPADR 209
|
....*.
gi 736004541 272 ILTLKV 277
Cdd:cd01407 210 KADLVI 215
|
|
| SIR2 |
COG0846 |
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ... |
23-290 |
4.55e-69 |
|
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440607 Cd Length: 243 Bit Score: 214.64 E-value: 4.55e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 23 ALDALHTFVERHPRLLVLTGAGISTDSGIPGYRDRNGQWMRSPPIQL--HEFLGSDAAR--RRYWARsmigWPVVGRARP 98
Cdd:COG0846 3 KIERLAELLREAKRIVVLTGAGISAESGIPDFRGPDGLWEKYDPEEVasPEAFRRDPELvwAFYNER----RRLLRDAEP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 99 NGSHVALARLGGAGRIERLVTQNVDGLHQRAGSDDVIELHGGINGVTCLDCGAHHaratiqtvleaDNPELLgaqaepaa 178
Cdd:COG0846 79 NAAHRALAELEKAGKLVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGKRY-----------DLEDVL-------- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 179 dgdahlewAALDTFRIPACPACGGLLKPAVVFFGENVPRERVALASQALDAADALLVVGSSLMVYSGYRFCVWAQAQHKP 258
Cdd:COG0846 140 --------EDLEGELPPRCPKCGGLLRPDVVWFGEMLPEEALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKRAGAP 211
|
250 260 270
....*....|....*....|....*....|..
gi 736004541 259 LAALNLGHTRADPILTLKVEAHCAPALDALVA 290
Cdd:COG0846 212 LVEINPEPTPLDSLADLVIRGDAGEVLPALVE 243
|
|
| SIR2 |
cd00296 |
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ... |
36-270 |
5.41e-65 |
|
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.
Pssm-ID: 238184 [Multi-domain] Cd Length: 222 Bit Score: 203.73 E-value: 5.41e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 36 RLLVLTGAGISTDSGIPGYRDRN-GQWMRSPPiqlhEFLGSDAARRRYWARSMIGWP-----VVGRARPNGSHVALARLG 109
Cdd:cd00296 2 RVVVFTGAGISTESGIPDFRGLGtGLWTRLDP----EELAFSPEAFRRDPELFWLFYkerryTPLDAKPNPAHRALAELE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 110 GAGRIERLVTQNVDGLHQRAGS--DDVIELHGGINGVTCLDCGAHHARATIQtvleadnpellgaqaepaadgdahlewa 187
Cdd:cd00296 78 RKGKLKRIITQNVDGLHERAGSrrNRVIELHGSLDRVRCTSCGKEYPRDEVL---------------------------- 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 188 alDTFRIPACPACGGLLKPAVVFFGENVPRERVALASQALDAADALLVVGSSLMVYSGYRFCVWAQAQHKPLAALNLGHT 267
Cdd:cd00296 130 --EREKPPRCPKCGGLLRPDVVDFGEALPKEWFDRALEALLEADLVLVIGTSLTVYPAARLLLRAPERGAPVVIINREPT 207
|
...
gi 736004541 268 RAD 270
Cdd:cd00296 208 PAD 210
|
|
| PRK00481 |
PRK00481 |
NAD-dependent deacetylase; Provisional |
24-292 |
1.20e-54 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 234777 Cd Length: 242 Bit Score: 177.68 E-value: 1.20e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 24 LDALHTFVERHPRLLVLTGAGISTDSGIPGYRDRNGQWMRSPPIQL--HEFLGSDAAR--RRYWARsmigWPVVGRARPN 99
Cdd:PRK00481 3 IEELAEILDKAKRIVVLTGAGISAESGIPDFRSANGLWEEHRPEDVasPEGFARDPELvwKFYNER----RRQLLDAKPN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 100 GSHVALARLGGAGRIERLVTQNVDGLHQRAGSDDVIELHGGINGVTCLDCGAHHaratiqTVLEADNPELlgaqaepaad 179
Cdd:PRK00481 79 AAHRALAELEKLGKLVTVITQNIDGLHERAGSKNVIELHGSLLRARCTKCGQTY------DLDEYLKPEP---------- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 180 gdahlewaaldtfriPACPACGGLLKPAVVFFGENVPRERVALASQALDAADALLVVGSSLMVYSGYRFCVWAQAQHKPL 259
Cdd:PRK00481 143 ---------------PRCPKCGGILRPDVVLFGEMLPELAIDEAYEALEEADLFIVIGTSLVVYPAAGLPYEAREHGAKT 207
|
250 260 270
....*....|....*....|....*....|...
gi 736004541 260 AALNLGHTRADPILTLKVEAHCAPALDALVARL 292
Cdd:PRK00481 208 VEINLEPTPLDSLFDLVIHGKAGEVVPELVEEL 240
|
|
| SIR2_Af2 |
cd01413 |
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, ... |
36-279 |
9.05e-54 |
|
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The Sir2 homolog from the archaea Sulfolobus solftaricus deacetylates the non-specific DNA protein Alba to mediate transcription repression.
Pssm-ID: 238704 Cd Length: 222 Bit Score: 174.86 E-value: 9.05e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 36 RLLVLTGAGISTDSGIPGYRDRNGQWMRSPPIQLHEFLGSDAARRRYWARSMIGWPVVGRARPNGSHVALARLGGAGRIE 115
Cdd:cd01413 6 KTVVLTGAGISTESGIPDFRSPDGLWKKYDPEEVASIDYFYRNPEEFWRFYKEIILGLLEAQPNKAHYFLAELEKQGIIK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 116 RLVTQNVDGLHQRAGSDDVIELHGGINGVTCLDCGAHHARATIQTVLEADnpellgaqaepaadgdahlewaaldtfrIP 195
Cdd:cd01413 86 AIITQNIDGLHQRAGSKNVIELHGTLQTAYCVNCGSKYDLEEVKYAKKHE----------------------------VP 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 196 ACPACGGLLKPAVVFFGENVPRERVALASQALDAADALLVVGSSLMVYSGYRFCVWAQAQHKPLAALNLGHTRADPILTL 275
Cdd:cd01413 138 RCPKCGGIIRPDVVLFGEPLPQALLREAIEAAKEADLFIVLGSSLVVYPANLLPLIAKENGAKLVIVNADETPFDYIADL 217
|
....
gi 736004541 276 KVEA 279
Cdd:cd01413 218 VIQD 221
|
|
| prot_deacyl_CobB |
NF040867 |
NAD-dependent protein deacetylase; |
37-292 |
1.26e-53 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 468804 Cd Length: 242 Bit Score: 175.07 E-value: 1.26e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 37 LLVLTGAGISTDSGIPGYRDRNGQWMRSPPIQLHEFLGSDAARRRYWARSMIGWPVVGRARPNGSHVALARLGGAGRIER 116
Cdd:NF040867 13 AIAFTGAGISTESGIPTFRGPDGLWRRYDPEELATIEAFERDPKLVWEFYRWRMEKLFDAKPNPAHYALAELERMGILKA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 117 LVTQNVDGLHQRAGSDDVIELHGGINGVTCLDCGA-HHARATIQTVLEADNPellgaqaepaadgdahlewaaldtfriP 195
Cdd:NF040867 93 VITQNVDGLHQRAGSRNVIELHGNMRRVRCTSCGRtYDLEEVLRKIDKGELP---------------------------P 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 196 ACPACGGLLKPAVVFFGENVP----RERVALASQaldaADALLVVGSSLMVYSGYRFCVWAQAQHKPLAALNLGHTRADP 271
Cdd:NF040867 146 RCPECGGLLRPDVVLFGEPLPddalEEAFELAER----SDVVLVVGSSLTVYPAAYLPYIAKENGGKLIIINPEETPLDP 221
|
250 260
....*....|....*....|.
gi 736004541 272 ILTLKVEAHCAPALDALVARL 292
Cdd:NF040867 222 IADIVLRGRAGEVLPKLVEEV 242
|
|
| SIRT5_Af1_CobB |
cd01412 |
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ... |
35-289 |
5.64e-49 |
|
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.
Pssm-ID: 238703 Cd Length: 224 Bit Score: 162.76 E-value: 5.64e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 35 PRLLVLTGAGISTDSGIPGYRDRNGQWMRSPPIQL-------------HEFLgsdAARRRywarsmigwpVVGRARPNGS 101
Cdd:cd01412 1 RRVVVLTGAGISAESGIPTFRDADGLWARFDPEELatpeafardpelvWEFY---NWRRR----------KALRAQPNPA 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 102 HVALARLGGAGRIERLVTQNVDGLHQRAGSDDVIELHGGINGVTCLDCGAhharatiQTVLEADNPELLgaqaepaadgd 181
Cdd:cd01412 68 HLALAELERRLPNVLLITQNVDGLHERAGSRNVIELHGSLFRVRCSSCGY-------VGENNEEIPEEE----------- 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 182 ahlewaaldtfrIPACPACGGLLKPAVVFFGENVPrERVALASQALDAADALLVVGSSLMVYSGYRFCVWAQAQHKPLAA 261
Cdd:cd01412 130 ------------LPRCPKCGGLLRPGVVWFGESLP-LALLEAVEALAKADLFLVIGTSGVVYPAAGLPEEAKERGARVIE 196
|
250 260
....*....|....*....|....*...
gi 736004541 262 LNLGHTRADPILTLKVEAHCAPALDALV 289
Cdd:cd01412 197 INPEPTPLSPIADFAFRGKAGEVLPALL 224
|
|
| SIR2 |
pfam02146 |
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ... |
42-244 |
7.13e-44 |
|
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i
Pssm-ID: 426621 Cd Length: 179 Bit Score: 147.78 E-value: 7.13e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 42 GAGISTDSGIPGYRDRNGQWMRSPPIQLH--EFLGSDAARRRY---WARSMIGWPVvGRARPNGSHVALARLGGAGRIER 116
Cdd:pfam02146 1 GAGISTESGIPDFRSDDGLYAKLAPEELAspEAFFSNPELVWDpepFYNIARELLP-GEAQPNPAHYFIAKLEDKGKLLR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 117 LVTQNVDGLHQRAGSDDVIELHGGINGVTCLDCgahHARATIQTVLEADNPEllgaqaepaadgdahlewaaldtfRIPA 196
Cdd:pfam02146 80 LITQNIDGLHERAGSKKVVELHGSFAKARCVSC---HQKYTGETLYERIRPE------------------------KVPH 132
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 736004541 197 CPACGGLLKPAVVFFGENVPrERVALASQALDAADALLVVGSSLMVYS 244
Cdd:pfam02146 133 CPQCGGLLKPDIVFFGENLP-DKFHRAYEDLEEADLLIVIGTSLKVYP 179
|
|
| PRK14138 |
PRK14138 |
NAD-dependent deacetylase; Provisional |
39-278 |
1.37e-43 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 172627 [Multi-domain] Cd Length: 244 Bit Score: 149.20 E-value: 1.37e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 39 VLTGAGISTDSGIPGYRDRNGQWMRSPP--IQLHEFLGSDAARRRYWARSMIgwPVVgRARPNGSHVALARLGGAGRIER 116
Cdd:PRK14138 16 TLTGAGISTPSGIPDFRGPQGIYKKYPQnvFDIDFFYSHPEEFYRFAKEGIF--PML-EAKPNLAHVLLAKLEEKGLIEA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 117 LVTQNVDGLHQRAGSDDVIELHGGINGVTCLDCGahhARATIQTVLEadnpellgaqaepaadgdahlewaALDTFRIPA 196
Cdd:PRK14138 93 VITQNIDRLHQKAGSKKVIELHGNVEEYYCVRCG---KRYTVEDVIE------------------------KLEKSDVPR 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 197 CPACGGLLKPAVVFFGENVPRERVALASQALDAADALLVVGSSLMVYSGYRFCVWAQAQHKPLAALNLGHTRADPILTLK 276
Cdd:PRK14138 146 CDDCSGLIRPNIVFFGEALPQDALREAIRLSSKASLMIVMGSSLVVYPAAELPLITVRSGGKLVIVNLGETPLDDIATLK 225
|
..
gi 736004541 277 VE 278
Cdd:PRK14138 226 YN 227
|
|
| SIRT7 |
cd01410 |
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ... |
35-277 |
4.81e-40 |
|
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238701 Cd Length: 206 Bit Score: 138.97 E-value: 4.81e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 35 PRLLVLTGAGISTDSGIPGYRDRNGQWMRSPPIQLheflgsdaARRRYWARSmigwpvvgRARPNGSHVALARLGGAGRI 114
Cdd:cd01410 1 KHLVVFTGAGISTSAGIPDFRGPNGVWTLLPEDKG--------RRRFSWRFR--------RAEPTLTHMALVELERAGLL 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 115 ERLVTQNVDGLHQRAGSDD--VIELHGGINGVTCLDCGAHHARATiqtVLEAdnpelLGAQAEPaadgdahlewaaldtf 192
Cdd:cd01410 65 KFVISQNVDGLHLRSGLPRekLSELHGNMFIEVCKSCGPEYVRDD---VVET-----RGDKETG---------------- 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 193 riPACPACGGLLKPAVVFFGENVPRERVALASQALDAADALLVVGSSLMVYSGYRFCVWAQAQHKPLAALNLGHTRADPI 272
Cdd:cd01410 121 --RRCHACGGILKDTIVDFGERLPPENWMGAAAAACRADLFLCLGTSLQVTPAANLPLKAARAGGRLVIVNLQPTPKDKL 198
|
....*
gi 736004541 273 LTLKV 277
Cdd:cd01410 199 ADLVI 203
|
|
| SIR2H |
cd01411 |
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species ... |
36-243 |
2.09e-36 |
|
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238702 Cd Length: 225 Bit Score: 130.18 E-value: 2.09e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 36 RLLVLTGAGISTDSGIPGYRDRNGQW---MRSPPIQL--HEFLGSDAARRRYWARSMIGWPvvgRARPNGSHVALARLGG 110
Cdd:cd01411 10 RIVFFTGAGVSTASGIPDYRSKNGLYneiYKYSPEYLlsHDFLEREPEKFYQFVKENLYFP---DAKPNIIHQKMAELEK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 111 AGRIeRLVTQNVDGLHQRAGSDDVIELHGGINGVTCLDCGAHharatiqtvleadnpellgaqaepaadgdahleWAALD 190
Cdd:cd01411 87 MGLK-AVITQNIDGLHQKAGSKNVVEFHGSLYRIYCTVCGKT---------------------------------VDWEE 132
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 736004541 191 TFRIPACPACGGLLKPAVVFFGENVPRERVALASQALDAADALLVVGSSLMVY 243
Cdd:cd01411 133 YLKSPYHAKCGGVIRPDIVLYEEMLNESVIEEAIQAIEKADLLVIVGTSFVVY 185
|
|
| PTZ00409 |
PTZ00409 |
Sir2 (Silent Information Regulator) protein; Provisional |
24-267 |
6.08e-31 |
|
Sir2 (Silent Information Regulator) protein; Provisional
Pssm-ID: 173599 [Multi-domain] Cd Length: 271 Bit Score: 116.94 E-value: 6.08e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 24 LDALHTFVERHPRLLVLTGAGISTDSGIPGYRDRN-GQWMRSPPIQLHEFLGsdaarrrYWARSMIGWPVV------GRA 96
Cdd:PTZ00409 18 LEDLADMIRKCKYVVALTGSGTSAESNIPSFRGPSsSIWSKYDPKIYGTIWG-------FWKYPEKIWEVIrdissdYEI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 97 RPNGSHVALARLGGAGRIERLVTQNVDGLHQRAGSDDVIELHGGINGVTCLDCgahhaRATIQTvleadNPELLGAQAEP 176
Cdd:PTZ00409 91 ELNPGHVALSTLESLGYLKFVVTQNVDGLHEESGNTKVIPLHGSVFEARCCTC-----RKTIQL-----NKIMLQKTSHF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 177 AADgdahlewaaldtfRIPACPaCGGLLKPAVVFFGENVPRERVALASQALDAADALLVVGSSLMVYSGYRFCVWAQAQH 256
Cdd:PTZ00409 161 MHQ-------------LPPECP-CGGIFKPNVILFGEVIPKSLLKQAEKEIDKCDLLLVVGTSSSVSTATNLCYRAHRKK 226
|
250
....*....|.
gi 736004541 257 KPLAALNLGHT 267
Cdd:PTZ00409 227 KKIVEVNISKT 237
|
|
| SIRT1 |
cd01408 |
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and ... |
36-243 |
1.47e-26 |
|
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The nuclear SIRT1 has been shown to target the p53 tumor suppressor protein for deacetylation to suppress DNA damage, and the cytoplasmic SIRT2 homolog has been shown to target alpha-tubulin for deacetylation for the maintenance of cell integrity.
Pssm-ID: 238699 Cd Length: 235 Bit Score: 104.25 E-value: 1.47e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 36 RLLVLTGAGISTDSGIPGYRDRN-GQWMR----SPP-----IQLHEFLGSDA-----ARRRYwarsmigwPvvGRARPNG 100
Cdd:cd01408 2 KIVVLVGAGISTSAGIPDFRSPGtGLYANlaryNLPypeamFDISYFRKNPRpfyalAKELY--------P--GQFKPSV 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 101 SHVALARLGGAGRIERLVTQNVDGLHQRAG--SDDVIELHGGINGVTCLDCGAhharatiqtvleadnpellgaqaepAA 178
Cdd:cd01408 72 AHYFIKLLEDKGLLLRNYTQNIDTLERVAGvpDDRIIEAHGSFATAHCIKCKH-------------------------KY 126
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 736004541 179 DGDAHLEwaALDTFRIPACPACGGLLKPAVVFFGENVPRERVALASQALDAADALLVVGSSLMVY 243
Cdd:cd01408 127 PGDWMRE--DIFNQEVPKCPRCGGLVKPDIVFFGESLPSRFFSHMEEDKEEADLLIVIGTSLKVA 189
|
|
| PTZ00408 |
PTZ00408 |
NAD-dependent deacetylase; Provisional |
36-264 |
3.81e-23 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 240405 Cd Length: 242 Bit Score: 95.27 E-value: 3.81e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 36 RLLVLTGAGISTDSGIPGYRDRNGQWMR-------SPpiqlHEFLGSDAARRRYW---ARSMIGWPVvgraRPNGSHVAL 105
Cdd:PTZ00408 6 CITILTGAGISAESGISTFRDGNGLWENhrvedvaTP----DAFLRNPALVQRFYnerRRALLSSSV----KPNKAHFAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 106 ARLGG---AGRIErLVTQNVDGLHQRAGSDDVIELHGGINGVTCldcgahharatiqtvleadnpellgaqaepAADGDA 182
Cdd:PTZ00408 78 AKLEReyrGGKVV-VVTQNVDNLHERAGSTHVLHMHGELLKVRC------------------------------TATGHV 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 183 hLEWAALDTFRIPACPACG--GLLKPAVVFFGEN-VPRERValaSQALDAADALLVVGSSLMVYSGYRFCVWAQAQHKPL 259
Cdd:PTZ00408 127 -FDWTEDVVHGSSRCKCCGcvGTLRPHIVWFGEMpLYMDEI---ESVMSKTDLFVAVGTSGNVYPAAGFVGRAQFYGATT 202
|
....*
gi 736004541 260 AALNL 264
Cdd:PTZ00408 203 LELNL 207
|
|
| PTZ00410 |
PTZ00410 |
NAD-dependent SIR2; Provisional |
24-243 |
1.96e-18 |
|
NAD-dependent SIR2; Provisional
Pssm-ID: 185600 Cd Length: 349 Bit Score: 84.15 E-value: 1.96e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 24 LDALHTFVERH--PRLLVLTGAGISTDSGIPGYRdrngqwmrSPPIQLHEFLG-------SDA-----ARRR-----YWA 84
Cdd:PTZ00410 17 FEGLARYIERNnvTKILVMVGAGISVAAGIPDFR--------SPHTGIYAKLGkynlnspTDAfsltlLREKpevfySIA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 85 RSMIGWPvvGRARPNGSHVALARLGGAGRIERLVTQNVDGLHQRAGSDD--VIELHGGINGVTCLDCgahHARATIQTvl 162
Cdd:PTZ00410 89 REMDLWP--GHFQPTAVHHFIRLLADEGRLLRCCTQNIDGLERAAGVPPslLVEAHGSFSAASCIEC---HTPYDIEQ-- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736004541 163 eadnpellgAQAEPAADgdahlewaaldtfRIPACPACGGLLKPAVVFFGENVPRERVALASQAlDAADALLVVGSSLMV 242
Cdd:PTZ00410 162 ---------AYLEARSG-------------KVPHCSTCGGIVKPDVVFFGENLPDAFFNVHHDI-PEAELLLIIGTSLQV 218
|
.
gi 736004541 243 Y 243
Cdd:PTZ00410 219 H 219
|
|
| |
