NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|736049444|ref|WP_034195093|]
View 

MULTISPECIES: Lrp/AsnC family transcriptional regulator [Burkholderia]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-132 1.24e-52

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 163.41  E-value: 1.24e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736049444   1 MDELDWKLIALLQANGRISYTELARQVHLSVPAVTERVKRLESTGVIGGYTARIDPAAAGYPVSALIGITVPQPAKAKFL 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEFA 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 736049444  81 KLLETIPEVVECHHVTGADSYVMRFVAVSMAHLEQL----IERVNLYGETRTSIVM 132
Cdd:COG1522   83 EALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFllerLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-132 1.24e-52

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 163.41  E-value: 1.24e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736049444   1 MDELDWKLIALLQANGRISYTELARQVHLSVPAVTERVKRLESTGVIGGYTARIDPAAAGYPVSALIGITVPQPAKAKFL 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEFA 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 736049444  81 KLLETIPEVVECHHVTGADSYVMRFVAVSMAHLEQL----IERVNLYGETRTSIVM 132
Cdd:COG1522   83 EALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFllerLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 1-107 8.32e-39

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 127.25  E-value: 8.32e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736049444     1 MDELDWKLIALLQANGRISYTELARQVHLSVPAVTERVKRLESTGVIGGYTARIDPAAAGYPVSALIGITVPQPAK-AKF 79
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKlEEF 80

                           90       100
                   ....*....|....*....|....*...
gi 736049444    80 LKLLETIPEVVECHHVTGADSYVMRFVA 107
Cdd:smart00344  81 LEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-136 2.69e-20

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 81.29  E-value: 2.69e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736049444   1 MDELDWKLIALLQANGRISYTELARQVHLSVPAVTERVKRLESTGVIGGYTARIDPAAAGYPVSALIGITVpQPAK--AK 78
Cdd:PRK11179   7 IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIIL-KSAKdyPS 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736049444  79 FLKLLETIPEVVECHHVTGADSYVMRFVAVSMAHLEQ-LIERVNLYGE---TRTSIVMSTPL 136
Cdd:PRK11179  86 ALAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHvLINKIQTIDEiqsTETLISLQNPI 147
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
2-42 1.79e-16

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 68.55  E-value: 1.79e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 736049444    2 DELDWKLIALLQANGRISYTELARQVHLSVPAVTERVKRLE 42
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 2-47 1.53e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 35.35  E-value: 1.53e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 736049444   2 DELDWKLIALLqANGRISYTELARQVHLSVPAVTERVKRLESTGVI 47
Cdd:cd00090    6 DPTRLRILRLL-LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLV 50
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-132 1.24e-52

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 163.41  E-value: 1.24e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736049444   1 MDELDWKLIALLQANGRISYTELARQVHLSVPAVTERVKRLESTGVIGGYTARIDPAAAGYPVSALIGITVPQPAKAKFL 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEFA 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 736049444  81 KLLETIPEVVECHHVTGADSYVMRFVAVSMAHLEQL----IERVNLYGETRTSIVM 132
Cdd:COG1522   83 EALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFllerLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 1-107 8.32e-39

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 127.25  E-value: 8.32e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736049444     1 MDELDWKLIALLQANGRISYTELARQVHLSVPAVTERVKRLESTGVIGGYTARIDPAAAGYPVSALIGITVPQPAK-AKF 79
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKlEEF 80

                           90       100
                   ....*....|....*....|....*...
gi 736049444    80 LKLLETIPEVVECHHVTGADSYVMRFVA 107
Cdd:smart00344  81 LEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-136 2.69e-20

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 81.29  E-value: 2.69e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736049444   1 MDELDWKLIALLQANGRISYTELARQVHLSVPAVTERVKRLESTGVIGGYTARIDPAAAGYPVSALIGITVpQPAK--AK 78
Cdd:PRK11179   7 IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIIL-KSAKdyPS 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736049444  79 FLKLLETIPEVVECHHVTGADSYVMRFVAVSMAHLEQ-LIERVNLYGE---TRTSIVMSTPL 136
Cdd:PRK11179  86 ALAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHvLINKIQTIDEiqsTETLISLQNPI 147
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-132 6.54e-20

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 80.58  E-value: 6.54e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736049444   1 MDELDWKLIALLQANGRISYTELARQVHLSVPAVTERVKRLESTGVIGGYTARIDPAAAGYPVSALIGITVPQPAK---A 77
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPdvfE 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 736049444  78 KFLKLLETIPEVVECHHVTGADSYVMRFVAVSMAHLEQLIE----RVNLYGETRTSIVM 132
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGetllRLPGVNDTRTYVVM 150
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
2-42 1.79e-16

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 68.55  E-value: 1.79e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 736049444    2 DELDWKLIALLQANGRISYTELARQVHLSVPAVTERVKRLE 42
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
3-47 1.59e-14

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 63.61  E-value: 1.59e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 736049444    3 ELDWKLIALLQANGRISYTELARQVHLSVPAVTERVKRLESTGVI 47
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 67-134 2.04e-14

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 64.08  E-value: 2.04e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 736049444   67 IGITV-PQPAKAKFLKLLETIPEVVECHHVTGADSYVMRFVAVSMAHLEQLIER----VNLYGETRTSIVMST 134
Cdd:pfam01037   1 VEVKLePGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREklrsLPGVARTETSIVLST 73
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
5-47 1.72e-05

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 41.43  E-value: 1.72e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 736049444     5 DWKLIALLQANGRISYTELARQVHLSVPAVTERVKRLESTGVI 47
Cdd:smart00347  12 QFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLV 54
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 6-47 7.01e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 35.99  E-value: 7.01e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 736049444    6 WKLIALLQANGRISYTELARQVHLSVPAVTERVKRLESTGVI 47
Cdd:pfam01047   6 FHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLI 47
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 2-47 1.53e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 35.35  E-value: 1.53e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 736049444   2 DELDWKLIALLqANGRISYTELARQVHLSVPAVTERVKRLESTGVI 47
Cdd:cd00090    6 DPTRLRILRLL-LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLV 50
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-45 4.53e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 35.33  E-value: 4.53e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 736049444   5 DWKLIALLQANGRISYTELARQVHLSVPAVTERVKRLESTG 45
Cdd:COG1846   40 QFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80
COG4190 COG4190
Predicted transcriptional regulator, contains HTH domain [Transcription];
6-47 4.57e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443344  Cd Length: 121  Bit Score: 35.26  E-value: 4.57e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 736049444   6 WKLIALLQANGRISYTELARQVHLSVPAVTERVKRLESTGVI 47
Cdd:COG4190   55 LELLRAIAEEGPESIRELARRLGRDVKNVHRDLKTLEELGLV 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH