|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
18-416 |
2.42e-98 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 299.19 E-value: 2.42e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 18 GWLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMG 97
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 98 GIVASFFMTEVWQLLLLWGVVIGVGTGMTALVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWRTA 177
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 178 LTLSVAVIATAMVLVLLLMRDHPADVGLPAYgetvvtkpvkqdhnLLATLASPLVTLKSVSGNPVFWVLFGTFFVCGLST 257
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLRRRPADLALRAY--------------DDASPASPGSTLKEALRSASFWLLALAFFLCGFAV 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 258 NGLIQTHwISICGDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRFDNRFLLFWFYGLRGLSLLYLSFSGFSFVELSVF 337
Cdd:cd17355 227 VGLIVHL-VPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLF 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 736475023 338 AVFYGLDWVATVPPTVKLAAENFGREKAGLVFGWVFAGHQLGAATAAFGAGFFKSDFDTYMPALQIAGLMCMIAAVSVL 416
Cdd:cd17355 306 AALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVL 384
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
17-421 |
2.13e-36 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 137.32 E-value: 2.13e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 17 YGWLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIM 96
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 97 GGIVASFFMTEVWQLLLlWGVVIGVGTGMTALVlGATVATRWFSK-RRGLVIGLMTASNATGQLVFLPLLAALTEAYGWR 175
Cdd:COG2223 82 IGLLLLALAVSYWLLLL-LGLLLGIGGGGSFAV-GIALVSKWFPPdRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 176 TALTLSVAVIATAMVLVLLLMRDHPADVGLPAygetvvtkpvkqdhnllatlASPLVTLKSVSGNPVFWVLFGTFFVCGL 255
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPPAGAAAAA--------------------KASLRDQLEALRDPRFWLLSLLYFGTFG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 256 STNGLIQTHWISICGDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRFDNRFLLFWFYGLRGLSLLYLSFSGFSFVELS 335
Cdd:COG2223 220 SFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 336 VFAVFYGLDWVATVPPTVKLAAENFGREKAGLVFGWVFAGHQLGAATAAFGAGFFKSDFDTYMPALQIAGLMCMIAAVSV 415
Cdd:COG2223 300 VLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLT 379
|
....*.
gi 736475023 416 LLLRKP 421
Cdd:COG2223 380 LLLYRR 385
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
4-421 |
2.76e-29 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 118.05 E-value: 2.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 4 TRLASWMAGRNLHYGWLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFG 83
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 84 IRQVVSTALALIMGGIVASFFMTEVWQLLLLWgVVIGVGTGMtALVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLP 163
Cdd:COG2807 82 LERTLLLALLLLAAGLLLRSLAPSVALLLAGT-ALIGAGIAV-GNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 164 LLAALTEAYGWRTALTLSVAVIATAMVLVLLLMRDHPADvglpaygetvvtkpvkqdhnllATLASPLVTLKSVSGNPVF 243
Cdd:COG2807 160 LTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAA----------------------AAAAPAAASLRSLWRSPLA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 244 WVLFGTFFVCGLSTNGLIqTHWISICGDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRFDNRFLLFWFYGLrglsLLY 323
Cdd:COG2807 218 WLLTLFFGLQSLLYYAVV-AWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGL----LGL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 324 LSFSGFSFVELS---VFAVFYGLDWVATVPPTVKLAAENFGR-EKAGLVFGWVFAGHQLGAATAAFGAGFFKSDFDTYMP 399
Cdd:COG2807 293 AGLLGLLLAPGSlpwLWAVLLGLGQGGLFPLALTLIGLRARTpAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTA 372
|
410 420
....*....|....*....|..
gi 736475023 400 ALQIAGLMCMIAAVSVLLLRKP 421
Cdd:COG2807 373 ALLLLAALAVLMLVAGLLAGRP 394
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
19-418 |
2.97e-29 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 117.71 E-value: 2.97e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 19 WLVAATTFLtMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMGG 98
Cdd:cd17353 3 WLVLLGAVL-MHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 99 IVASFFMTEVWQLLLLWGVVIGVGTGmtaLVLGATVAT--RWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWRT 176
Cdd:cd17353 82 FILSAFAISLPLLFLGYGVLGGIGAG---IGYITPVSTavKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 177 ALTLSVAVIATAMVLVLLLMRDHPADvglpaygetvVTKPVKQDHNLLATLASPLVTLKSVSGNPVFWVLFGTFFVCGLS 256
Cdd:cd17353 159 TFLILGIIFLIIIVIGAFLIRDPPKG----------WVPPGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 257 TNGLIQTHWISICGDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRFDNRFLLFWFYGLRGLSLLYLSFSGFSFVELSV 336
Cdd:cd17353 229 GLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 337 FAVFYGLDWVATVPPTVKLAAENFGREKAGLVFGWVFAGHQLGAATAAFGAGFFKSDFDtYMPALQIAGLMCMIAAVSVL 416
Cdd:cd17353 309 GVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGG-YNAAFIIAAALSLVALALAL 387
|
..
gi 736475023 417 LL 418
Cdd:cd17353 388 LL 389
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
18-419 |
4.19e-26 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 108.41 E-value: 4.19e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 18 GWLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMG 97
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 98 GIVASFFMTEVWQLLLLWGVVIGVGTGMtALVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWRTA 177
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGL-IYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 178 LtLSVAVIATAMVLVLLLMRdhpadvglpaygetvvtkpvkqdhnllatlasplvTLKSVSGnpVFWVLFGTFFVCGLST 257
Cdd:cd17352 160 L-LILGGLCLNLCVCGLLLR-----------------------------------LLKDPTF--VLLALGVSFAMLGFFV 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 258 nglIQTHWISICGDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRFD-NRFLLFWFY-GLRGLSLLYLSFSgFSFVELS 335
Cdd:cd17352 202 ---PFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRiGRLYLYIFTlLILGLSLLAFPLA-TTYVGLI 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 336 VFAVFYGLDWVATVPPTVKLAAENFGREKAGLVFGWVFAGHQLGAATAAFGAGFFKSDFDTYMPALQIAGLMCMIAAVSV 415
Cdd:cd17352 278 VFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLL 357
|
....
gi 736475023 416 LLLR 419
Cdd:cd17352 358 FLLP 361
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-421 |
6.66e-23 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 99.17 E-value: 6.66e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 17 YGWLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIM 96
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 97 GGIVASFFMTEVWQLLLLWgVVIGVGTGMTALVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWRT 176
Cdd:COG2271 87 LATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 177 ALTLSVAVIATAMVLvlllmrdhpadvglpaygetvvtkpvkqdhnllatlasplvtlksvsgnpVFWVLFGTFFVCGLS 256
Cdd:COG2271 166 AFLILGLPGLLLALL--------------------------------------------------RFWLLALAYFLVYFA 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 257 TNGlIQTHWISICGD-FGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRFDNR--FLLFWFYGLRGLSLLYLSFSGfSFVE 333
Cdd:COG2271 196 LYG-FLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLP-SPAL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 334 LSVFAVFYGLDWVATVPPTVKLAAENFGREKAGLVFGWVFAGHQLGAATAAFGAGFFKSDFDtYMPALQIAGLMCMIAAV 413
Cdd:COG2271 274 AIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAAL 352
|
....*...
gi 736475023 414 SVLLLRKP 421
Cdd:COG2271 353 LALLLLRE 360
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
18-417 |
2.57e-21 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 94.79 E-value: 2.57e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 18 GWLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMG 97
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 98 GIVASFFMTEVWQLLLLWGVVIGVGTGMTALVLgATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWRTA 177
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSA-VLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 178 LTLSVAVIATAMVLVLLLMRDHPADVGLPaygetvvtkpvkqdhnlLATLASPLVTLKSVSGNPVFWVLFGTFFVC--GL 255
Cdd:cd17314 160 YTILGILAAIVLSVVSLLGFKEPPDNQAR-----------------LHVQKKKTQTMGEIFRDKVFWILFIAIFLVliGG 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 256 STNGLIQTHWISICGDFGMAAVTaaGTLAVIGIFDFFGTIFAGWLSDRFDNRFLLFW-FYGLRGLSLLYLSFSGFSF-VE 333
Cdd:cd17314 223 FLFIANMASLVRSLQLDAPSFVT--KLMSIYGLFNAFGRLLWGIVADFFGGRLSTLSiLLTILGLGLCAFLFLLKMTpVG 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 334 LSVFAVFYGLDWVATVPPTVKLAAENFGREKAGLVFGWVFAGHQLGAATAAFGAGFFKSDFDTYMPALQIAGLMCMIAAV 413
Cdd:cd17314 301 LVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASA 380
|
....
gi 736475023 414 SVLL 417
Cdd:cd17314 381 ILLA 384
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
19-378 |
4.73e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 93.50 E-value: 4.73e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 19 WLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMGG 98
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 99 IVASFFMTEVWQLLLLWgVVIGVGTGMTALVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWRTAL 178
Cdd:COG2814 89 SLLCALAPSLWLLLAAR-FLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 179 TLSVAVIATAMVLVLLLMRDHPAdvglpaygetvvtkpvkqdhnllATLASPLVTLKSVSGNPVFWVLFGTFFVCGLSTN 258
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPESRP-----------------------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 259 GLIQTHWISICGDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRFDNRFLLFWFYGLRGLSLLYLSFSGfSFVELSVFA 338
Cdd:COG2814 225 ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG-SLWLLLLAL 303
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 736475023 339 VFYGLDWVATVPPTVKLAAENFGREKAGLVFGWVFAGHQL 378
Cdd:COG2814 304 FLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
26-378 |
1.69e-17 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 83.24 E-value: 1.69e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 26 FLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMGGIVASFFM 105
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 106 TEVWQLLLLWgVVIGVGTGMTALVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWRTALTLSVAVI 185
Cdd:pfam07690 83 SSLWLLLVLR-VLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 186 ATAMVLVLLLMRDHPADVGLPAygetvvtkpvkqdhnlLATLASPLVTLKSVSGNPVFWVLFGtfFVCGLSTNGLIQTHW 265
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPA----------------EEARLSLIVAWKALLRDPVLWLLLA--LLLFGFAFFGLLTYL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 266 ISICGDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRFDNRFLLFWFYGLRGLSLLYLSFSGF--SFVELSVFAVFYGL 343
Cdd:pfam07690 224 PLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLtlSSLWLLLALLLLGF 303
|
330 340 350
....*....|....*....|....*....|....*
gi 736475023 344 DWVATVPPTVKLAAENFGREKAGLVFGWVFAGHQL 378
Cdd:pfam07690 304 GFGLVFPALNALVSDLAPKEERGTASGLYNTAGSL 338
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
18-343 |
1.05e-15 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 78.25 E-value: 1.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 18 GWLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMG 97
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 98 GIVASFFMTEVWQLLLLWGVVIGVGTGMTaLVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWRTA 177
Cdd:cd17422 81 GMITASFASSIVEMYLTIGIISGLGYCFT-FLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYC 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 178 LtLSVAVIATAMVLVLLLMRdhpadvglpaygetvvtkpVKQDHNLLatlasplvtlksvsgnpvFWVLFGTFFVCGLST 257
Cdd:cd17422 160 L-LVVGALQLNIVVCGALLR-------------------VLKEPGFI------------------CYALFGLFATLGFFA 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 258 NGLiqtHWISICGDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDR--FDNRFLLFWFYGLRGLSLLYLSFSgFSFVELS 335
Cdd:cd17422 202 PQL---YIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKcpIRKIYIELICVILLCVVLLLFPFA-YGFWSLL 277
|
....*...
gi 736475023 336 VFAVFYGL 343
Cdd:cd17422 278 VCSIFYGF 285
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
18-350 |
8.65e-15 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 75.51 E-value: 8.65e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 18 GWLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMG 97
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 98 GIVASFFMTEVWQLLLLWGVVIGVGTgmtALVLGATVAT--RWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWR 175
Cdd:cd17423 81 GFLLASFATSLLHLYLCIGLLSGLGW---ALVFAPTMATvsRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 176 TALTLsVAVIATAMVLVLLLMRDHPADVGLPAygeTVVTKPVKQDHNLLATLASPLVTLKSVSGNPVFWVLFgtffvcgl 255
Cdd:cd17423 158 GALLL-LSALSLHLVPCGALLRPLALPGDPPA---PPRSLSAAFGLSLLTHRAFLRYALATTLINTGYFIPY-------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 256 stngliqTHWISICGDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRFDNR--FLLFWFYGLRGLSLLYLSFsGFSFVE 333
Cdd:cd17423 226 -------VHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRllHLLVLWTALTGLSLLLLPL-AKVYGS 297
|
330
....*....|....*..
gi 736475023 334 LSVFAVFYGLDWVATVP 350
Cdd:cd17423 298 LLALAVAYGFCAGALAP 314
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
21-370 |
6.94e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 69.53 E-value: 6.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 21 VAATTFLTMLATagamgSAGVMIQPLH-QEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMGGI 99
Cdd:cd17325 1 LSLALFLDMLGY-----GIIIPILPLYaESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVST 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 100 VASFFMTEVWQLLLLwGVVIGVGTGMTALVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWRTALT 179
Cdd:cd17325 76 LLFAFATSYWQLLLA-RFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 180 LSVAVIATAMVLVLLLMRDhpadvglpaygetvvtkPVKQDHNLLATLASPLVTLKSVSGNPVFWVLFGTFFVCGLSTNG 259
Cdd:cd17325 155 VCAALALLALVLALLLLPE-----------------PRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 260 LIQTHWISICGDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRFDNRFLLFWFYGLRGLSLLYLSFSGfSFVELSVFAV 339
Cdd:cd17325 218 LEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT-SFWLLLLLLA 296
|
330 340 350
....*....|....*....|....*....|.
gi 736475023 340 FYGLDWVATVPPTVKLAAENFGREKAGLVFG 370
Cdd:cd17325 297 LLGLGLGLVFPATLALLADIVPPEGRGTAMG 327
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
18-184 |
6.11e-11 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 63.70 E-value: 6.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 18 GWLVAATTFLTMLATAGAMGSAGVM----IQPLHQEFGWDIADISSAMAVRLVLfgllGPFAAAFMNHFGIRQVVSTALA 93
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILnmewLEEFQQSRGLTAWISSLSMGITLIV----GPFIGLFINTCGCRKTAIIGGI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 94 LIMGGIVASFFMTEVWQLLLLWGVVIGVGTGMTALVLGATVAtRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYG 173
Cdd:cd17429 77 LTSLGWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVG-QYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFG 155
|
170
....*....|.
gi 736475023 174 WRTALTLSVAV 184
Cdd:cd17429 156 WRNAMFIQGAV 166
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
27-340 |
7.40e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 63.34 E-value: 7.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 27 LTMLATAGAMGSAGVMIQPL----HQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMGGIVAS 102
Cdd:cd17324 2 LALALAAFAIGTTEYVIQGLlpdiARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 103 FFMTEVWqLLLLWGVVIGVGTGMTALVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWRTALTLSV 182
Cdd:cd17324 82 ALAPSFA-LLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 183 AVIATAMVLVLLLMRDHPADVGLPaygetvvtkpvkqdhnlLATLASPLVTLKsvsgNPVFWVLFGTFFVCGLSTNGLIQ 262
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGS-----------------LGLLSSLLLLLR----NPRLRLAYLITFLLFGGFFALYT 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 736475023 263 THWISICGDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRFDNRFLLFWFYGLRGLSLLYLSFSGFSFVELSVFAVF 340
Cdd:cd17324 220 YLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLW 297
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
26-416 |
2.09e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 62.06 E-value: 2.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 26 FLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMGGIVASFFM 105
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 106 TEVWqLLLLWGVVIGVGTGMTALVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEA--YGWRTALTLSVA 183
Cdd:cd06174 82 PSFW-LLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 184 VIATAMVLVLLLMRDHPADVGLPaygetvvtkpvkqdhNLLATLASPLVTLKSVSGNPVFWVLFGTFFVCGLSTNGLIQT 263
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAK---------------NEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 264 HWISICGDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRFDNRFLLFWFYGLRGLSLLYLSFSGFSFVELSVFAVFYGL 343
Cdd:cd06174 226 LPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGF 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 736475023 344 DWVATVPPTVKLAAENFGREKAGLVFGWVFAGHQLGAATAAFGAGFFKSDFDTYMPALQIAGLMCMIAAVSVL 416
Cdd:cd06174 306 GLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
16-343 |
3.17e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 61.60 E-value: 3.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 16 HYGWLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALI 95
Cdd:TIGR00895 13 RYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 96 MGGIVASFFMTEVWQLLLLwGVVIGVGTGMTALVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWR 175
Cdd:TIGR00895 93 SVFTLLCALATNVTQLLIL-RFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 176 TALTlsVAVIATAMVLVLLLMRDH-PADVGLPAYGETVVTKPVKQDHNLLATLASPLVTLKSVSG--NPVFWVLF----- 247
Cdd:TIGR00895 172 SLFY--VGGIAPLLLLLLLMRFLPeSIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGtkRSVFKALFqgkta 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 248 -GTFFVCGLSTNGLIQTHWISICGDFGMAAVTAAGTLAVIGIFDF-----FGTIFAGWLSDRFdNRFLLFWFYGLRGLSL 321
Cdd:TIGR00895 250 rITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFnfggvIGSIIFGWLADRL-GPRVTALLLLLGAVFA 328
|
330 340
....*....|....*....|..
gi 736475023 322 LYLSFSGFSFVELSVFAVFYGL 343
Cdd:TIGR00895 329 VLVGSTLFSPTLLLLLGAIAGF 350
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
91-307 |
8.39e-10 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 60.08 E-value: 8.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 91 ALALIMGGIVASF--FMTEVWQLLLLWgVVIGVGTGMTALVLGATVaTRWFSKR-RGLVIGLM-TASNATGQLVFLPLLA 166
Cdd:TIGR00881 64 PIGLILCAIVNLFfgFSTSLWVMAALW-ALNGIFQGMGWPPCGRTV-TKWFSRSeRGTWVSFWnCSHNVGGGLLPPLVLF 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 167 ALTEAYGWRTALTLSVAVIATAMVLVLLLMRDHPADVGLPAYGETVVTKPVKQDHNLLATLASPLVTLKSVSGNPVFWVL 246
Cdd:TIGR00881 142 GIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYI 221
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736475023 247 -FGTFFVCGLSTnGLIQTHWISICGDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRFDNR 307
Cdd:TIGR00881 222 sLGYVFVYVVRT-GILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNG 282
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
17-175 |
6.90e-09 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 57.44 E-value: 6.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 17 YGWLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGW---DIADISSAMAVrlVLFGlLGPFAAAFMNHFGIRQVVSTALA 93
Cdd:TIGR00892 16 WGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQAtysETAWISSIMLA--VLYA-GGPISSILVNRFGCRPVVIAGGL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 94 LIMGGIVASFFMTEVWQLLLLWGVVIGVGTGMTaLVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYG 173
Cdd:TIGR00892 93 LASLGMILASFSSNVIELYLTAGFITGLGLAFN-FQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFG 171
|
..
gi 736475023 174 WR 175
Cdd:TIGR00892 172 WR 173
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
94-304 |
1.38e-08 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 56.57 E-value: 1.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 94 LIMGGIVASFFMT--EVWQLLLLW---GVVIGVGTGMTALVLgatvaTRWFSKRR-GLVIGLMTAS-NATGQLVflPLLA 166
Cdd:cd17343 75 LVLSGLTTVAFSGssSVWVFSILWflnGLAQGLGWPPCAKIL-----RKWFSPSQfGTWWSVLSTSmNLAGSLG--PILA 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 167 A-LTEAYGWRTALTLSVAVIATAMVLVLLLMRDHPADVGLPAYGEtvvtkPVKQDHNllATLASPLVTLKSVSGNPVFWV 245
Cdd:cd17343 148 TlLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEE-----EESKGKK--KKSPRGESTLKELLLSPFLWL 220
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 246 L-FGTFFVCGLSTNGLIQTHwISICGDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRF 304
Cdd:cd17343 221 LsLGYLVVFGVKTAVTDWGQ-LFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWA 279
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
19-328 |
1.90e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 56.02 E-value: 1.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 19 WLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMGG 98
Cdd:COG0738 7 RRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 99 IVAsFFMTEVWQLLLLWGVVIGVGTGMTaLVLGATVATRWFSKRRGLVIGLMTASNATGQLVFlPLLAALTEAYGWRTAL 178
Cdd:COG0738 87 LLL-FALAPSYPLLLLALFLLGLGLGLL-DVAANPYVAALGPETAASRLNLLHAFFSLGALLG-PLLGGLLILLGLSLSW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 179 TLSVAVIATAMVLVLLLmrdhpadvglpaygetVVTKPVKQDHNLLATLASPLVTLKSVSGNPVFWVLFGTFFVCGLSTN 258
Cdd:COG0738 164 HLPYLILAVLLLLLALL----------------FLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEG 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736475023 259 GLIQthWISI--CGDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRFDNRFLLFWFYGLRGLSLLYLSFSG 328
Cdd:COG0738 228 AIGD--WLPLylKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAP 297
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
40-418 |
2.49e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 55.27 E-value: 2.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 40 GVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMGGIVASFFMTEVWQLLLLWGVVi 119
Cdd:cd17319 23 SVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLL- 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 120 GVGTGmTALVLGATVATRWFSKR-RGLVIGLMTASNATGQLVFLPLLAALTEAYGWRTA--LTLSVAVIATAMVLVLLlm 196
Cdd:cd17319 102 GVAEA-GFFPGAIKALAEWFPAReRGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAfiIEGLLGLLLAVLWWFYL-- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 197 rdhpadvglpaygetvvtkpvkqdhnllatlasplvtlksvsgnPVFWVLFGTFFVCGLSTNGLIQTHWISICGDFGMAA 276
Cdd:cd17319 179 --------------------------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 277 VTAAGTLAVIGIFDFFGTIFAGWLSDRF--DNRFLLFWFYGLRGLSLLYLSFSGFSFVELSVFAVFYGLDWVATVPPTVK 354
Cdd:cd17319 215 KQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWS 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 736475023 355 LAAENFGREKAGLVFGWVFAGHQLGAATAAFGAGFFKSDFDTYMPALQIAGLMCMIAAVSVLLL 418
Cdd:cd17319 295 LPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
78-416 |
2.80e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 55.32 E-value: 2.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 78 FMNHFGIRQVVSTALaLIMGGIVASFFMTEVWQLLLLWGVVIGVGTGmTALVLGATVATRWFSKR-RGLVIGLMTASNAT 156
Cdd:cd17475 54 LLDRFGERRVLAVGL-LLMGAAALLMALVGSYPVLLVLLFLVGAGYG-SVQPGGGRAIMRWFPPReRGLAMGIRQTGVPL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 157 GQLVFLPLLAALTEAYGWRTALTLSVAVIATAMVLVLLLMRDHPADVGLPAYGETVVTkpvkqdhnllatlasplvTLKS 236
Cdd:cd17475 132 GGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESASTLLR------------------SLKE 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 237 VSGNPVFW-VLFGTFFVCGLSTngLIQTHWISICGDFGMAAVTAAGT-LAVIGIFDFFGTIFAGWLSDRFDN---RFLLF 311
Cdd:cd17475 194 VLRNRDVWlIAIAGALLVAPQF--ALLTFLLLFLHDHLGLSVVAAGAlLAVAQLGGALGRIGLGRVSDRVFGgrrRPVLV 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 312 WFYGLRGLSLLYLSF--SGFSFVELSVFAVFYGLDWVATVPPTVKLAAENFGREKAGLVFGWVFAGHQLGAATAAFGAGF 389
Cdd:cd17475 272 ITAAIAAAALLVLSLlsPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGL 351
|
330 340
....*....|....*....|....*..
gi 736475023 390 FKSDFDTYMPALQIAGLMCMIAAVSVL 416
Cdd:cd17475 352 LVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
18-197 |
1.08e-06 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 50.20 E-value: 1.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 18 GWLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMG 97
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 98 GIVASFFMTEVWQLLLLWGVVIGVGTGmtaLVLGATVAT--RWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWR 175
Cdd:cd17428 81 GLMLSAFAPNIYFLIFSYGIVVGLGCG---LVYAATVTItcQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLD 157
|
170 180
....*....|....*....|..
gi 736475023 176 TALtLSVAVIATAMVLVLLLMR 197
Cdd:cd17428 158 GCL-LIVGALALNLLACGSLMR 178
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
65-316 |
1.40e-06 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 49.88 E-value: 1.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 65 LVLFGLLGPFAAAFMNHFGIRQVVSTALALIMGGIVASFFMTEVWqlLLLWGVVIGVGTGMTALVLGATVaTRWFSKRRG 144
Cdd:cd17339 44 LLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIAL--LFLGTALAGAGIAVGNVLLPSLI-KRDFPRRVG 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 145 LVIGLMTASNATGQLV--FLPLLAALTEAYGWRTALTLSVAVIATAMVLVLLLMRDHPAdvglpaygetvvtkpvkqdhn 222
Cdd:cd17339 121 LMTGLYTTSMNLGAALasGLSVPLAQALGGGWRGALAIWALPALLALLIWLPQLRRRKR--------------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 223 llATLASPLVTLKSVSGNPVFWVLfgTFFVCGLSTNGLIQTHWI-SICGDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLS 301
Cdd:cd17339 180 --AAAAAAPLTKISVWRSPLAWQV--TLFMGLQSLLFYTLMAWLpTILIDAGLSAATAGWLLSLFQLVGIPASLLVPILA 255
|
250
....*....|....*
gi 736475023 302 DRFDNRFLLFWFYGL 316
Cdd:cd17339 256 TRLKNQRPIVVLLAV 270
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
18-175 |
1.78e-06 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 49.73 E-value: 1.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 18 GWLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMG 97
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 98 GIVASFFMTEVWQLLLLWGVVIGVGTGM----TALVLGatvatRWFSKRRGLVIGLmtasNATGQLVFL----PLLAALT 169
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALnfqpSLIMLG-----RYFDKRRPLANGL----AAAGSPVFLsalsPLGQILL 151
|
....*.
gi 736475023 170 EAYGWR 175
Cdd:cd17430 152 EEYGWR 157
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
59-331 |
2.32e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 49.56 E-value: 2.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 59 SAMAVRLVLFGLLGPFAAAFM-NHFGIRQVVSTALALIMGGIVASFFMTEVWQLLLLWGVVIGVGTGMtaLVLGATVATR 137
Cdd:cd17341 37 GLLVAIPVLAGALLRLPYGFLcDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFAGAN--FASGQPWASF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 138 WFSKRR-----GLVIGLMTASNATGQLVFLPLLAAL---TEAYGWRTALTLSVAVIATAMVLVLLLMRDHPadvglpayg 209
Cdd:cd17341 115 WFPKEKiggaaGGIAGAGNMGVAVSQLLAPLIAGAIvfdGGFVGWRNAFFVPGILLAIAAVLVLLFGDDLP--------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 210 etvvTKPVKQDHNLLATLAsplvtlksVSGNPVFWVL-------FGTFFVCGLSTNGLIQTHwisicgdFGMAAVTAAGT 282
Cdd:cd17341 186 ----TGKASALEFLKVQLA--------VLKNYRTWILsllygvtFGSFVGFSNVLPTYFKTR-------FGLPLVTAGIL 246
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 736475023 283 LAVIGIFDFFGTIFAGWLSDRFDNRFLLFWFYGLRGLSLLYLSFSGFSF 331
Cdd:cd17341 247 AALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTS 295
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
49-343 |
2.62e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 49.11 E-value: 2.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 49 EFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMGGIVASFFMTEVWQLLLLWGVVigvGTGMTAL 128
Cdd:cd17504 25 EFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQ---GIGGAVF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 129 VLGATVATRWFSKRR-GLVIGLMTASNATGQLVFLPLLAALTEAYGWRTALTLSVAVIatamvlvlllmrdhpadvglpa 207
Cdd:cd17504 102 PLAFALVREEFPPERvPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA---------------------- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 208 ygetvvtkpvkqdhnLLATLASPLVTLKSVSgNPVFWVLFGTFFVCGLSTNGLIQTHWISI----CGDFGMAAVTAAGTL 283
Cdd:cd17504 160 ---------------VLLAALVPLIDLRLLR-RRNVLLANITALLAGFGMFMVFQLLPQLLqlptPTGFGLGITEAGLLL 223
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 284 AVIGIFDFFGTIFAGWLSDRFDNRFLLFWFYGLRGLSLLYLSFSGFSFVELSVFAVFYGL 343
Cdd:cd17504 224 LPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGI 283
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
18-419 |
2.77e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 49.11 E-value: 2.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 18 GWLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGllgPFAAAFMNHFGIRQVVSTALALIMG 97
Cdd:cd17473 1 LITLLLASTLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFA---PLAGWLADRFGRKRLLIAGLLLYGI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 98 GIVASFFMTEVWQLLLLwGVVIGVGTGMTALVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEaYGWRTA 177
Cdd:cd17473 78 GGVAGLFLDSLYALLAS-RALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 178 LtlsvAVIATAMVLVLLLMRdhpadvglpaygetVVTKPVKQDHnllATLASPLVTLKSVSGNPVFWVLFGTFFVCGLST 257
Cdd:cd17473 156 F----LVYLLALPVLILVLL--------------FLPEPARKSK---SAASPGAATAAALPWKRVLPIYFLAFLAMLLFY 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 258 NGLIQTHWIsICGDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRFDNRFLLFWFYGLRGLSLLYLSFSGfSFVELSVF 337
Cdd:cd17473 215 VIPIQLPFL-LQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALAS-GLWVVLLG 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 338 AVFYGLDWVATVPPTVKLAAENFGREKAGLVFGWVFAGHQLGAATAAFGAGFFKSDFDTYMPALQIAGLMCMIAAVSVLL 417
Cdd:cd17473 293 AILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
..
gi 736475023 418 LR 419
Cdd:cd17473 373 LR 374
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
91-318 |
2.91e-06 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 49.32 E-value: 2.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 91 ALALIMGGIVASFF--MTEVWQLLLLWGV---VIGVGTGMTALVLgatvaTRWFSK-RRGLVIGLM-TASNATGQLVFLp 163
Cdd:PRK11663 92 GIGLIATGIINILFgfSSSLWAFALLWVLnafFQGWGWPVCAKLL-----TAWYSRtERGGWWAIWnTAHNVGGALIPL- 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 164 LLAALTEAYGWRTALTLSVAVIATAMVLVLLLMRDHPADVGLPAYGETvvtkpvKQDHNLLAT------LASPLVTLKSV 237
Cdd:PRK11663 166 VVGAIALHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEW------RHDALELAQqqegagLSRKEILTKYV 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 238 SGNPVFWVLFGTF---FVCGLSTNG-----LIQTHWISIcgdfgmaaVTAAGTLAVIGIFDFFGTIFAGWLSDRfdnrfl 309
Cdd:PRK11663 240 LLNPYIWLLSFSYvlvYVVRAAINDwgnlyMSETLGVDL--------VTANSAVSMFELGGFIGALVAGWGSDK------ 305
|
....*....
gi 736475023 310 lfWFYGLRG 318
Cdd:PRK11663 306 --LFNGNRG 312
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-200 |
5.32e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 48.33 E-value: 5.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 19 WLVAATTFLTMLATAGAMGSAGVMiqpLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMGG 98
Cdd:COG2271 183 WLLALAYFLVYFALYGFLTWLPTY---LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 99 IVASFF-MTEVWQLLLLWGVVIGVGTGMTALVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWRTA 177
Cdd:COG2271 260 LALLLLaLLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
170 180
....*....|....*....|...
gi 736475023 178 LTLSVAVIATAMVLVLLLMRDHP 200
Cdd:COG2271 340 FLLLAALALLAALLALLLLRETR 362
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
39-343 |
7.69e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 47.58 E-value: 7.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 39 AGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMGGIVASFFMTEVWQLLLlWGVV 118
Cdd:cd17365 18 MGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL-LRFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 119 IGVGTGMTALVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWRtaltlSVAVIATAMVLVLLLMrd 198
Cdd:cd17365 97 TGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWR-----SVFLLGGVPPLILLPL-- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 199 hpadvglpaygetvvtkpvkqdhnLLATLAsplvtlksvsgnpvfwvLFGTFFVCGLSTNGLIQthWI-SICGDFGMAAV 277
Cdd:cd17365 170 ------------------------LRGTLL-----------------LWVTFFMGLLLVYLLNS--WLpKLMVEAGYSLS 206
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736475023 278 TAAGTLAVIGIFDFFGTIFAGWLSDRFDNRFLLFWFYGLRGLSLLYLSFSGFSFVELSVFAVFYGL 343
Cdd:cd17365 207 QALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGA 272
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
18-342 |
1.10e-05 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 47.11 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 18 GWLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMG 97
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 98 GIVASFFMTEVWQLLLLWGVVIGVGTGMTALVLGATVAtRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWRTA 177
Cdd:cd17424 81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVG-KYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 178 LtlsvaVIATAMVLvlllmrdhpadvglpaygetvvtkpvkqdhNLLATLASPLVTLKsvsgnPVFWVLFGTFFVCGLST 257
Cdd:cd17424 160 L-----LILGGFVL------------------------------NLCVCGALMRFLLM-----PDFLVLAVSVLFLAYGC 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 258 NGLIqTHWISICGDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRF----DNRFLLFWFYGLRGLSLLYLSFSGfSFVE 333
Cdd:cd17424 200 SPPF-VYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRclkkYRYFCYLFAVGMDGLCCLFLPILK-TFPL 277
|
....*....
gi 736475023 334 LSVFAVFYG 342
Cdd:cd17424 278 LVPFSFTFG 286
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
41-373 |
1.17e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.17 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 41 VMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMGGIVASFFMTEVWQLLLLwGVVIG 120
Cdd:cd17478 17 ALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLL-VALAG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 121 VGTGMTAlVLGATVATRWFSKRRGLVIGLMTASNATGQlVFLPLLAALTEAYGWRTALTLsVAVIATAMVLVLLLMRDHP 200
Cdd:cd17478 96 IGSAAFH-PEGARLASQAAGGRRGLAMSIFSVGGNLGF-ALGPLIAAALVALFGGLGLLI-LLIIPGLAVALLLLRLRPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 201 ADVGLPAYGETVVTKPVKQDHNLLATLASPLVTLKSvsgnpvfwvlfgtFFVCGLSTngLIQTHWISIcgdfGMAAVTAA 280
Cdd:cd17478 173 KKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRS-------------WVLSSLTT--FLPFYLVQR----GYSLVFAG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 281 GTLAVIGIFDFFGTIFAGWLSDRFDNRFLLFWFYGLRGLSLLYLSFSGFSFVELSVFAVFYGLdwVATVPPTVKLAAENF 360
Cdd:cd17478 234 LLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLL--FASFPVTVVLAQELL 311
|
330
....*....|....*.
gi 736475023 361 GREK---AGLVFGWVF 373
Cdd:cd17478 312 PGNVglaSGLMMGLSF 327
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
40-200 |
2.75e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.11 E-value: 2.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 40 GVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVStaLALIMGGIVASF--FMTEVWQLLLLWGV 117
Cdd:cd17312 23 SVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMS--AGLLLSALANIFmgFSTSLWFFAVLWGL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 118 vIGVGTGMTALVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWRTALTLSVAVIATAMVLVLLLMR 197
Cdd:cd17312 101 -NGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLR 179
|
...
gi 736475023 198 DHP 200
Cdd:cd17312 180 DSP 182
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
18-175 |
5.55e-05 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 45.19 E-value: 5.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 18 GWLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMG 97
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 98 GIVASFFMTEVWQLLLLWGVVIGVGTGMTaLVLGATVATRWFSKRRGLVIGLMTAsnatGQLVFLPLLAALTE----AYG 173
Cdd:cd17427 81 GMISASFCNSVMQLYLCIGVIGGLGLAFN-LQPALTIIGKYFYKKRPIANGLAMA----GSPVFLSTLAPLNQflfnQFG 155
|
..
gi 736475023 174 WR 175
Cdd:cd17427 156 WR 157
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
18-195 |
8.79e-05 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 44.44 E-value: 8.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 18 GWLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISS-------AMAVRLVLFglLGPFAAAFMNHFGIRQVVST 90
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKLGDPEASfkaawvgALAMGMIFF--CSPIVSCFTDKIGCRLTAFA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 91 ALALIMGGIVASFFMTEVWQLLLLWGVVIGVGTGMtALVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTE 170
Cdd:cd17420 79 GAAVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSF-AYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLD 157
|
170 180
....*....|....*....|....*
gi 736475023 171 AYGwrtaLTLSVAVIATAMVLVLLL 195
Cdd:cd17420 158 SYG----LEGTLRVLSLFMFVLILC 178
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
18-175 |
1.29e-04 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 1.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 18 GWLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMG 97
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 98 GIVASFFMTEVWQLLLLWGVVIGVGTGMTaLVLGATVATRWFSKRRGLVIGLMTAsnatGQLVFLPLLAALTE----AYG 173
Cdd:cd17426 81 GLIAASFCNTVEGLYFCVGVVGGLGLAFN-LNPALTMIGKYFYKKRPLANGLAMA----GSPVFLSTLAPLNQwffdIFG 155
|
..
gi 736475023 174 WR 175
Cdd:cd17426 156 WR 157
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
41-304 |
1.85e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 43.38 E-value: 1.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 41 VMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTAL---ALIMGGI-VASFFMTEVWQLLLLWg 116
Cdd:cd17345 24 LAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLilsAIINILIgFVPSATSSVGLMFILL- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 117 VVIGVGTGMTALVLGATVaTRWFSKR-RGLVIGLM-TASNATGQLVflPLLAALTEAY---GWRTALTLSVAVIATAM-V 190
Cdd:cd17345 103 FLNGWFQGMGWPPSGRTM-VHWFSKKeRGTWTSIWnISHNVGGGLV--GPLAGLGLAIfgdGWWRGAFIFPAIIAIIVaV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 191 LVLLLMRDHPADVGLPAYGETVVTKPVKQDHNLLAT-LASPLVTLKSVSGNPVFW--------VLFGTFFVCGLSTNGLI 261
Cdd:cd17345 180 IVLFLGKDTPESEGLPPIEEYKGDYPEEADGEEEEQeLSAWEIFVKYVLKNKLLWyiaianvfVYLVRYGILDWAPTYLS 259
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 736475023 262 QTHwisicgdfGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRF 304
Cdd:cd17345 260 EVK--------GFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKL 294
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
19-301 |
2.81e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 42.49 E-value: 2.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 19 WLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMGG 98
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 99 IVASFFMTEVWqLLLLWGVVIGVGTGMTALVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWRTAL 178
Cdd:COG0477 93 SLLCGLAPSPE-LLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 179 TLSVAVIATAMVLVLLLMRDHPADVGLPAYGETVVTKPVKQDHNLLATLASPLVTLKSVSGNPVFWVLFGTFFVCGLSTN 258
Cdd:COG0477 172 LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 736475023 259 GLIQTHWISICGDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLS 301
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
89-370 |
3.12e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 42.64 E-value: 3.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 89 STALALIMGGIVasfFMTEVWQLL---LLWGVVIGVGTGMTALVlgATVATRwfsKRRGLVIGLMTASNATGQLVFLPLL 165
Cdd:cd17391 73 SLGMAIVIGLMA---FVTNVWQLLilrLLQGVFSGYVPNATALI--ASQTPK---EKSGWALGTLSTGVVAGTLIGPLLG 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 166 AALTEAYGWRTALTLSVAVIATAMVLVLLLMRDHpadvglpaygetvvTKPVKQdhnllATLASPLVTLKSVSGNPVFWV 245
Cdd:cd17391 145 GFLADLFGIRNVFFITGGLLFLAFLLTLFFVKED--------------FKPVEK-----KKMVSTKEVWNSVPNPSLLIS 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 246 LFGTFFVCGLSTNGL--IQTHWISICGDFGMAAVTAAG-TLAVIGIFDFFGTIFAGWLSDRFDNRFLLfwFYGLRGLSLL 322
Cdd:cd17391 206 LFVTTFIIQLANQSIepILTLYIRQLMGDASNLAFISGlVFSATGVSSLLSAPRLGKLGDRIGHHRIL--LGALLASALL 283
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 736475023 323 YLSFSGF-SFVELSVFAVFYGLDWVATVPPTVKLAAENFGREKAGLVFG 370
Cdd:cd17391 284 YIPQAFVqTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFG 332
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
40-326 |
3.64e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 42.67 E-value: 3.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 40 GVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMGGIVASFFMTEVWQLLLLWGVVi 119
Cdd:cd17371 19 GLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALA- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 120 GVGTGMTALVLGATVATRWFSKRRGLVIGLMTASNATGQLV----FLPLLAALTEAYGWRTALtlsvaVIATAMVLVLLL 195
Cdd:cd17371 98 GLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLatllAALLFPLLPPEIAWRVLF-----LLGALPALLVLF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 196 MRDHPADVglPAYGETVVTKPVKQDHNLLATLASPlvtlksvsgnpvfwVLFGTFFVCGLSTNGLIQTHWISIC------ 269
Cdd:cd17371 173 IRRFVKEP--PQWQAARAARRHFADRPSLRELFSP--------------PLLRTTLLASLLATGALGGYYGITTwlpsyl 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 736475023 270 -GDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRFDNRFLLFWFYGLRGLSLLYLSF 326
Cdd:cd17371 237 tGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFF 294
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
18-190 |
6.70e-04 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 41.68 E-value: 6.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 18 GWLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMG 97
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 98 GIVASFFMTEVWQLLLLWGVVIGVGTGMtALVLGATVATRWFSKRRGLVIGLMTASNATGqLVFLPLLAA-LTEAYGWRT 176
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCF-SFQSSVTVLGFYFVRRRALANALASTGTSIG-LTLWPLLSQyLLEEMGWRG 158
|
170
....*....|....
gi 736475023 177 ALTLSVAVIATAMV 190
Cdd:cd17425 159 SFLVFGGVLLNCCV 172
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
217-375 |
8.31e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 41.37 E-value: 8.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 217 VKQDHNLLATLASPLVTLKSVSGNPVFWVLFG--TFFVCGLSTNGLIQTHwisiCGDFGMAAVTAAGTLAVIGIFDFFGT 294
Cdd:cd17370 176 VVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLavALFALGNFSFAFLILR----AQELGLSAALIPLLYALFNLVYALAA 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 295 IFAGWLSDRFDNRFLLFWFYGLRGLSLLYLSFSGfSFVELSVFAVFYGLDWVATVPPTVKLAAENFGREKAGLVFGWVFA 374
Cdd:cd17370 252 YPAGRLSDRIGRKKLLILGYLSLALAYLGFALGS-SLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNT 330
|
.
gi 736475023 375 G 375
Cdd:cd17370 331 V 331
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
73-350 |
1.67e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.27 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 73 PFAAAFMNHFGIRQVVSTALALIMGGIVASFFMTEVWQLLLLwGVVIGVGTGMTALVLGATVATRWFSKRRGLVIGLMTA 152
Cdd:cd17489 49 PFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVL-RLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 153 SNATGQLVFLPLLAALTEAYGWRTALTLSVAVIATAMVLVlLLMRDHPADVGLPAYGETVVTKPVKQDHNLLATLAsplv 232
Cdd:cd17489 128 ATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLV-FLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALI---- 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 233 tlksvsgnpvfwVLFGTFFVCGLSTngLIQTHWISIcgdfgmAAVTAAGTLAVIGIFDFFGTIFAGWLSDRFDNRFLLFW 312
Cdd:cd17489 203 ------------LFLASIAYGAIST--FLPLYAAER------GISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIP 262
|
250 260 270
....*....|....*....|....*....|....*...
gi 736475023 313 FYGLRGLSLLYLSFSGfSFVELSVFAVFYGLDWVATVP 350
Cdd:cd17489 263 GLLLLALGLLLLSFAG-SPWMLLLAAVLYGLGFGLLFP 299
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
52-342 |
1.76e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.23 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 52 WDIADISSAMAVRLVLFGllgPFAAAFMNHFGIRQVVSTALALIMGGIVASFFMTEVWqLLLLWGVVIGVGTGMTALVLG 131
Cdd:cd17477 31 ALIGLVASAYYLGILLGS---PLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPW-VWFLLRFVMGIGLAGLFVVSE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 132 ATVATRWFSKRRGLVIGLMTASNATGQLVFlPLLAALTEAYGWrTALTLSVAVIATAMVLVLLLMRDHPAdvglpayget 211
Cdd:cd17477 107 SWLNALATNENRGRVLGLYSTVLGLGFALG-PLLLALVGTAGA-LPFLIAAVLLLLALVPLLLTRRAAPE---------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 212 vVTKPVKQDHNLLATLASPLVTLKSVSGnpvfwvLFGTFFVCGLSTNGLiqthwisicgDFGMAAVTAAGTLAVIGIFDF 291
Cdd:cd17477 175 -IEEAESISLRRLLRIAPLALLGAFVAG------FLEGAFYSLLPLYGL----------RLGLSVAQAALLLAAFVLGGL 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 736475023 292 FGTIFAGWLSDRFDNRFLLFWFYGLRGLSLLYLSFSGFSFVELSVFAVFYG 342
Cdd:cd17477 238 LLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWG 288
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
92-371 |
1.79e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.27 E-value: 1.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 92 LALIMGGIVASFFMTEVWQLLLLWGVVIGVGTGMTALV-----LGATVATRwfSKRRGLVIGLMTASNATGQLVFLPLLA 166
Cdd:COG2211 91 LALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNipysaLGAELTPD--YEERTRLSSWRFAFAGLGGLLASVLPP 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 167 ALTEAYGWRTALTLSVAVIATAMVLVLLLMrdhpadvglpaygetVVTKPVKQDHNLLATLASPLVTLKSVSGNPVFWVL 246
Cdd:COG2211 169 PLVAAFGGDAALGYRLTALIFAVLGLLAFL---------------LTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLL 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 247 FGTFFV--CGLSTNGLIQTHWISICgdFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRFDNRFLLFWFYGLRGLSLLYL 324
Cdd:COG2211 234 LLAYLLffLALALVAALLLYYFKYV--LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 736475023 325 SFSGFS-----FVELSVFAVFYGLDWV---ATVPPTVKLAAENFGREKAGLVFGW 371
Cdd:COG2211 312 FFLGPGnlwllLVLAALAGIGLGAILVlpwAMLADVVDYDEWKTGRRREGLYFGI 366
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
54-196 |
3.31e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.50 E-value: 3.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 54 IADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMGGIVASFFMTEVWQLLLLwGVVIGVGTGMTALVLGAT 133
Cdd:cd17489 226 ISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLA-AVLYGLGFGLLFPALQAL 304
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 736475023 134 VATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWRTALTLSVAVIATAMVLVLLLM 196
Cdd:cd17489 305 AVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
271-375 |
3.91e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 39.10 E-value: 3.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 271 DFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRFDNRFLLFWFYGLRGLSLLYLSFSGfSFVELSVFAVFYGLDWVATVP 350
Cdd:cd17325 25 SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT-SYWQLLLARFLQGLASAAVWP 103
|
90 100
....*....|....*....|....*
gi 736475023 351 PTVKLAAENFGREKAGLVFGWVFAG 375
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSA 128
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
48-193 |
6.49e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.68 E-value: 6.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 48 QEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVstALALIMGGIVASFFMTEVWQLLLLWGVVI-GVGTGMT 126
Cdd:cd17370 227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLL--ILGYLSLALAYLGFALGSSLWLLLLGFILwGLYMGAQ 304
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736475023 127 ALVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWRTALTLSVAVIATAMVLVL 193
Cdd:cd17370 305 ESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
18-191 |
6.57e-03 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 38.65 E-value: 6.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 18 GWLVAATTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMG 97
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 98 GIVASFFMTEVWQLLLLWGVVIGVGTGMTALVlGATVATRWFSKRrgLVIGLMTASNATGqLVFL--PLLAALTEAYGWR 175
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQA-AAVMTAKYFKKR--LATAYAIARSGMG-LTFAlaPFTQLLLDEYDWQ 156
|
170 180
....*....|....*....|
gi 736475023 176 TALTLSVAV----IATAMVL 191
Cdd:cd17421 157 GALLIFGGImlnlVASGMLL 176
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
46-328 |
8.45e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 37.97 E-value: 8.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 46 LHQEFGWDIADISSAMAVRLVLFGLlgPFAAAFMNH----FGIRQVVSTALALIMGGIVASFFMTEVWQLLLLWgVVIGV 121
Cdd:cd17316 25 LAAEFSLGLSLLQTGLLFAAGFLGR--PIGALLFGYlgdrIGRKKALILTLLLFGLATLLIGLLPTPILLLVLR-FLQGI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 122 GTGMTALVLGATVATRWFSKRRGLVIGLMTASNATGQ----LVFLPLLAALTEAYGWRTALtlsvaVIATAMVLVLLLMR 197
Cdd:cd17316 102 GIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGAllaaLVASLLIPLLSGDWGWRILF-----LIGALPALLALLLR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 198 dhpadvglpaygetvvtkpvkqdhnlLATLASPLVTLKSVSGNPVFWVLFGTFFVcglstngliqthwisicGDFGMAAV 277
Cdd:cd17316 177 --------------------------RRTLLLILLWFFISFGYYGLTTFLPTYLQ-----------------TVLGLSPA 213
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 736475023 278 TAAGTLAVIGIFDFFGTIFAGWLSDRFDNRFLLFWFYGLRGLSLLYLSFSG 328
Cdd:cd17316 214 TSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLL 264
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
39-307 |
9.22e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 37.99 E-value: 9.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 39 AGVMiQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAFMNHFGIRQVVSTALALIMGGIVASFFMTEVWQLLLLWGVV 118
Cdd:cd17328 19 AGVL-PDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 119 iGVGTGMTALVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTEA-YGWRTALTLSVAVIATAMVLVLLLMR 197
Cdd:cd17328 98 -GIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLLAILLLLFVR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 198 DHPadvglpaygetvvTKPVKQDHNLLATLASPLVTLKSVSGNPVF-WVLFGTFFVC----GLSTNGLIQTHWISICGDF 272
Cdd:cd17328 177 EPP-------------RGAAEGGVMAKSTATSFLADLKALAKNPSFiLSTLGFTAVSfvtgALAFWAPTFFLRAFGVGDL 243
|
250 260 270
....*....|....*....|....*....|....*
gi 736475023 273 GMAAVTAAgTLAVIGIFDFFGTIFAGWLSDRFDNR 307
Cdd:cd17328 244 SSADVGLI-FGAITCIAGVLGVLLGGILADRLRRK 277
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
18-173 |
9.97e-03 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 37.85 E-value: 9.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 18 GWLVAATTFLTMLATAGAMGSAGVMIQPLHQEFG-WDIADIS------SAMAVRLVLFglLGPFAAAFMNHFGIRQVVST 90
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGsKDDAQMRfktawvGSLSMGMIFF--CSPIVSVFTDLFGCRKTATG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736475023 91 ALALIMGGIVASFFMTEVWQLLLLWGVVIGVGTGMtALVLGATVATRWFSKRRGLVIGLMTASNATGQLVFLPLLAALTE 170
Cdd:cd17464 79 GAAVGFVGLLASSFVSSIEPLYFTYGIIFACGCSF-AYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLD 157
|
...
gi 736475023 171 AYG 173
Cdd:cd17464 158 SVG 160
|
|
| |
