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Conserved domains on  [gi|736476704|ref|WP_034498325|]
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MULTISPECIES: GntR family transcriptional regulator [Rhizobium/Agrobacterium group]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
21-234 6.54e-51

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 165.10  E-value: 6.54e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704  21 RPVVDQIYSALKSAILSRELFPGQAVSENEIGQSFNSSRTPVREALSRLRDDGLIVTLPSRGTYVSRLSEKNIRSAQFIR 100
Cdd:COG1802   10 ESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEVR 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704 101 EALEVAAVCRLCQiGLTAEAEQEIEHALNGQRAAMRNGDRKAFRVHDDQFHSALAAATGLERLESLLIREKAGLDRLRAL 180
Cdd:COG1802   90 AALEGLAARLAAE-RATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRL 168

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 736476704 181 AITDEAHMARLLSEHEAVYDAIRAGDEARATDNLRKHLRRVLGILSQVFENHQD 234
Cdd:COG1802  169 SLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAAA 222
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
21-234 6.54e-51

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 165.10  E-value: 6.54e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704  21 RPVVDQIYSALKSAILSRELFPGQAVSENEIGQSFNSSRTPVREALSRLRDDGLIVTLPSRGTYVSRLSEKNIRSAQFIR 100
Cdd:COG1802   10 ESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEVR 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704 101 EALEVAAVCRLCQiGLTAEAEQEIEHALNGQRAAMRNGDRKAFRVHDDQFHSALAAATGLERLESLLIREKAGLDRLRAL 180
Cdd:COG1802   90 AALEGLAARLAAE-RATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRL 168

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 736476704 181 AITDEAHMARLLSEHEAVYDAIRAGDEARATDNLRKHLRRVLGILSQVFENHQD 234
Cdd:COG1802  169 SLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAAA 222
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 22-86 1.39e-17

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 74.02  E-value: 1.39e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736476704  22 PVVDQIYSALKSAILSRELFPGQAV-SENEIGQSFNSSRTPVREALSRLRDDGLIVTLPSRGTYVS 86
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 99-210 3.41e-16

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 72.02  E-value: 3.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704   99 IREALEVAAVCRLCQIGlTAEAEQEIEHALNGQRAAMRNGDRKAFRVHDDQFHSALAAATGLERLESLLIREKAGLDRLR 178
Cdd:pfam07729   5 LRAALEPLAARLAAERA-TDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLRRLR 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 736476704  179 ALAITDEAHMARLLSEHEAVYDAIRAGDEARA 210
Cdd:pfam07729  84 RLLLSSPGRLRASLEEHRAILDAIRARDPEAA 115
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 99-220 2.87e-15

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 69.70  E-value: 2.87e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704    99 IREALEVAAVcRLCQIGLTAEAEQEIEHALNGQRAAMRNGDR-KAFRVHDDQFHSALAAATGLERLESLLireKAGLDRL 177
Cdd:smart00895   5 VRRALEPLAA-RLAAERATDEDLAALEALLDAMEAAAAAGDDlEEFAELDREFHRALAEAAGNPVLLELL---ESLRARL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 736476704   178 RALAITDEAHMARLLSEHEAVYDAIRAGDEARATDNLRKHLRR 220
Cdd:smart00895  81 RRLRRLSLEAARRALDEHRAILDAIRARDAEAARAAMREHLEA 123
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 16-221 3.89e-12

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 63.89  E-value: 3.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704  16 RLDLNRPVV-----DQIYSALKSAILSRELFPGQAV-SENEIGQSFNSSRTPVREALSRLRDDGLI---------VTLPS 80
Cdd:PRK03837   2 RNLRSRPIArkklsEEVEERLEQMIRSGEFGPGDQLpSERELMAFFGVGRPAVREALQALKRKGLVqishgerarVSRPS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704  81 RGTYVSRLS--EKNIRSAQ-----------------FIREALEVAavcrlcqiglTAEAEQEIEHALNGQRAAMrnGDRK 141
Cdd:PRK03837  82 ADTIIGQLSgmAKDFLSQSpdglahlkqarlffessLARYAAEHA----------TDEQIALLRKALERNSQSL--GDNA 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704 142 AFRVHDDQFHSALAAATG----LERLESLLirekAGLDRLRALAITDEAHMARLLSEHEAVYDAIRAGDEARATDNLRKH 217
Cdd:PRK03837 150 AFIRSDMEFHRVIAEIPGnpifMAIHEALL----DWLIEARPEVVILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSH 225


                 ....
gi 736476704 218 LRRV 221
Cdd:PRK03837 226 LNRV 229
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
21-234 6.54e-51

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 165.10  E-value: 6.54e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704  21 RPVVDQIYSALKSAILSRELFPGQAVSENEIGQSFNSSRTPVREALSRLRDDGLIVTLPSRGTYVSRLSEKNIRSAQFIR 100
Cdd:COG1802   10 ESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEVR 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704 101 EALEVAAVCRLCQiGLTAEAEQEIEHALNGQRAAMRNGDRKAFRVHDDQFHSALAAATGLERLESLLIREKAGLDRLRAL 180
Cdd:COG1802   90 AALEGLAARLAAE-RATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRL 168

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 736476704 181 AITDEAHMARLLSEHEAVYDAIRAGDEARATDNLRKHLRRVLGILSQVFENHQD 234
Cdd:COG1802  169 SLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAAA 222
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
20-234 6.81e-32

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 116.57  E-value: 6.81e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704  20 NRPVVDQIYSALKSAILSRELFPGQAV-SENEIGQSFNSSRTPVREALSRLRDDGLIVTLPSRGTYVSRLSEKNI----- 93
Cdd:COG2186    5 RRSLAEQVAEQLRELILSGELKPGDRLpSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALldpla 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704  94 ----RSAQFIREALEV-----AAVCRLCQIGLTAEAEQEIEHALNGQRAAMRNGDrkAFRVHDDQFHSALAAATGLERLE 164
Cdd:COG2186   85 lllaLDDASLRDLLEArlalePEAARLAAERATDEDLARLEAALAEMEAAADDGE--AFAEADLAFHRAIAEASGNPLLA 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704 165 SLLIREKAGLDRLRALAITDEAHMARLLSEHEAVYDAIRAGDEARATDNLRKHLRRVLGILSQVFENHQD 234
Cdd:COG2186  163 LLLESLRELLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALAERAR 232
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 22-86 1.39e-17

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 74.02  E-value: 1.39e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736476704  22 PVVDQIYSALKSAILSRELFPGQAV-SENEIGQSFNSSRTPVREALSRLRDDGLIVTLPSRGTYVS 86
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 99-210 3.41e-16

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 72.02  E-value: 3.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704   99 IREALEVAAVCRLCQIGlTAEAEQEIEHALNGQRAAMRNGDRKAFRVHDDQFHSALAAATGLERLESLLIREKAGLDRLR 178
Cdd:pfam07729   5 LRAALEPLAARLAAERA-TDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLRRLR 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 736476704  179 ALAITDEAHMARLLSEHEAVYDAIRAGDEARA 210
Cdd:pfam07729  84 RLLLSSPGRLRASLEEHRAILDAIRARDPEAA 115
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 99-220 2.87e-15

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 69.70  E-value: 2.87e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704    99 IREALEVAAVcRLCQIGLTAEAEQEIEHALNGQRAAMRNGDR-KAFRVHDDQFHSALAAATGLERLESLLireKAGLDRL 177
Cdd:smart00895   5 VRRALEPLAA-RLAAERATDEDLAALEALLDAMEAAAAAGDDlEEFAELDREFHRALAEAAGNPVLLELL---ESLRARL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 736476704   178 RALAITDEAHMARLLSEHEAVYDAIRAGDEARATDNLRKHLRR 220
Cdd:smart00895  81 RRLRRLSLEAARRALDEHRAILDAIRARDAEAARAAMREHLEA 123
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 25-85 1.72e-12

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 60.71  E-value: 1.72e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736476704   25 DQIYSALKSAILSRELFPGQAV-SENEIGQSFNSSRTPVREALSRLRDDGLIVTLPSRGTYV 85
Cdd:pfam00392   3 EQVYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 16-221 3.89e-12

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 63.89  E-value: 3.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704  16 RLDLNRPVV-----DQIYSALKSAILSRELFPGQAV-SENEIGQSFNSSRTPVREALSRLRDDGLI---------VTLPS 80
Cdd:PRK03837   2 RNLRSRPIArkklsEEVEERLEQMIRSGEFGPGDQLpSERELMAFFGVGRPAVREALQALKRKGLVqishgerarVSRPS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704  81 RGTYVSRLS--EKNIRSAQ-----------------FIREALEVAavcrlcqiglTAEAEQEIEHALNGQRAAMrnGDRK 141
Cdd:PRK03837  82 ADTIIGQLSgmAKDFLSQSpdglahlkqarlffessLARYAAEHA----------TDEQIALLRKALERNSQSL--GDNA 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704 142 AFRVHDDQFHSALAAATG----LERLESLLirekAGLDRLRALAITDEAHMARLLSEHEAVYDAIRAGDEARATDNLRKH 217
Cdd:PRK03837 150 AFIRSDMEFHRVIAEIPGnpifMAIHEALL----DWLIEARPEVVILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSH 225


                 ....
gi 736476704 218 LRRV 221
Cdd:PRK03837 226 LNRV 229
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
20-87 2.90e-11

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 61.03  E-value: 2.90e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 736476704  20 NRPVVDQIYSALKSAILSRELFPGQAV-SENEIGQSFNSSRTPVREALSRLRDDGLIVTLPSRGTYVSR 87
Cdd:COG2188    3 PVPLYLQIADALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAE 71
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
27-85 7.36e-11

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 56.04  E-value: 7.36e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704    27 IYSALKSAILSRELFPGQAV-SENEIGQSFNSSRTPVREALSRLRDDGLIVTLPSRGTYV 85
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 21-221 5.03e-10

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 57.85  E-value: 5.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704  21 RPVVDQIYSALKSAILSRELFPGQAV-SENEIGQSFNSSRTPVREALSRLRDDGLIVTLPSRGTYVSRL----SEKNIRS 95
Cdd:PRK10421   1 RRLSDEVADRVRALIEEKNLEAGMKLpAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRhetwSEQNIVQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704  96 ---------------AQFIREALEvAAVCRLCQIGLTAEAEQEIEHALNgqraAMRNGDRKAFRVHDDQFHSALAAATG- 159
Cdd:PRK10421  81 plktlmaddpdysfdILEARHAIE-ASTAWHAAMRATPGDKEKIQLCFE----ATLSEDPDLASQADVRFHLAIAEASHn 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 736476704 160 ---LERLESLLIREKAGLDRLRALAITDEAHMARLLSEHEAVYDAIRAGDEARATDNLRKHLRRV 221
Cdd:PRK10421 156 vvlLQTMRGFFDVLQSSVKQSRQRMYLVPPVFSQLTEQHQAVMDAILAGDAEGARKAMMAHLSFV 220
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
17-119 1.02e-08

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 51.72  E-value: 1.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704  17 LDLNRPVVDQIYSALKSAILSRELFPGQAV-SENEIGQSFNSSRTPVREALSRLRDDGLIVTLPSRGTYVSRLSEKNIRS 95
Cdd:COG1725    5 FDSGVPIYEQIADQIKEAIASGELKPGDRLpSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARELLEE 84

                         90       100
                 ....*....|....*....|....*.
gi 736476704  96 A--QFIREALEvAAVCRLCQIGLTAE 119
Cdd:COG1725   85 RreEFLEEALR-ELVAEARRLGLSLE 109
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 13-87 1.03e-07

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 51.75  E-value: 1.03e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736476704  13 TMERlDLNRPVVDQIYSALKSAILSRELFPGQAV-SENEIGQSFNSSRTPVREALSRLRDDGLIVTLPSRGTYVSR 87
Cdd:COG1167    4 RLDR-DSSGPLYLQLADALREAILSGRLPPGDRLpSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAA 78
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 28-228 5.40e-06

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 46.04  E-value: 5.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704  28 YSALKSAILSRELFPGQAVSENEIGQSFNSSRTPVREALSRLRDDGLIVTLPSRGTYVSRLSEKNIRSAQFIREALEvAA 107
Cdd:PRK11534  13 YRWLKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANME-AM 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704 108 VCRLCQIGLTAEAEQEI---EHALNgqRAAMRNGDRKAFRVHDDQ---FHSALAAATGLERLESLLIREKAGLDRLRALA 181
Cdd:PRK11534  92 LVSLAIARGGDEWEADVlakAHLLS--KLEACDASEKMLDEWDLRhqaFHTAIVAGCGSHYLLQMRERLFDLAARYRFIW 169

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 736476704 182 ITDEAHMARLLS----EHEAVYDAIRAGDEARATDNLRKHLRRVLGILSQV 228
Cdd:PRK11534 170 LRRTVLSVEMLEdkhdQHQTLTAAILARDTARASELMRQHLLTPIPIIQQA 220
PRK11414 PRK11414
GntR family transcriptional regulator;
26-231 2.27e-05

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 44.09  E-value: 2.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704  26 QIYSALKSAILSRELFPGQAVSENEIGQSFNSSRTPVREALSRLRDDGLIVTLPSRGTYVSRLSEKNIRSAQFIREALEV 105
Cdd:PRK11414  15 QVENDLKHQLSIGALKPGARLITKNLAEQLGMSITPVREALLRLVSVNALSVAPAQAFTVPEVSKRQLDEINRIRYELEL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704 106 AAVCrLCQIGLTAEAEQEIEHALNGQRAAMRNGD-------RKAFRVhdDQFHSAlAAATGLERLESLLIREKAGLDRLR 178
Cdd:PRK11414  95 MAVA-LAVENLTPQDLAELQELLEKLQQAQEKGDmeqiinaNRLFRL--AIYHRS-NMPILCEMIEQLWVRMGPSLHYLY 170

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 736476704 179 AlAITDEAHMARLLSEHEaVYDAIRAGDEARATDNLRKHLRRVLGILSQVFEN 231
Cdd:PRK11414 171 E-AINPAELREHIENYRL-LLAALKAKDKEGCRHCLAEIMQQNVAILYQQYNR 221
PRK09764 PRK09764
GntR family transcriptional regulator;
20-85 2.39e-04

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 40.97  E-value: 2.39e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736476704  20 NRPVVDQIYSALKSAILSRELFPGQAV-SENEIGQSFNSSRTPVREALSRLRDDGLIVTLPSRGTYV 85
Cdd:PRK09764   3 HKPLYRQIADRIREQIARGELKPGDALpTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYV 69
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 21-89 6.03e-04

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 40.13  E-value: 6.03e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704  21 RPVVDQIYSALKSAILSRELFPGQAV-SENEIGQSFNSSRTPVREALSRLRDDGLIVTLPSRGTYVSRLS 89
Cdd:PRK09990   6 RPIADVVAERIERLIVDGVLKVGQALpSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLN 75
PRK11402 PRK11402
transcriptional regulator PhoB;
19-85 1.27e-03

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 39.05  E-value: 1.27e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736476704  19 LNRPVVDQIYSALKSAIL---SRELF-PGQAV-SENEIGQSFNSSRTPVREALSRLRDDGLIVTLPSRGTYV 85
Cdd:PRK11402   2 TDRYSHQLLYATVRQRLLddiAQGVYqAGQQIpTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFV 73
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
25-218 3.36e-03

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 37.69  E-value: 3.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704  25 DQIYSALKSAILSRELFPGQAV-SENEIGQSFNSSRTPVREALSRLRDDGLIVTLPSRGTYVSR-----LSE------KN 92
Cdd:PRK09464  13 DVIEQQLEFLILEGTLRPGEKLpPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSslwqsFSDplvellSD 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736476704  93 IRSAQF----IREALEVAAVCRLCQIGlTAEAEQEIEHALNGQRAAMRNGDRKAFRVHDDQFHSALAAATG-------LE 161
Cdd:PRK09464  93 HPESQFdlleTRHALEGIAAYYAALRG-TDEDFERIRECHHAIELAQQSGDLDAEANAVMQYQIAVTEAAHnvvllhlLR 171

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 736476704 162 RLESLLirEKAGLDRLRALAITDEahMARLLSEHEA-VYDAIRAGDEARATDNLRKHL 218
Cdd:PRK09464 172 CMEPML--EQNVRQNFELLYRRRE--MLPKVSSHRArIFEAIVAGKPEKAREASHRHL 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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