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Conserved domains on  [gi|736488199|ref|WP_034506349|]
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MULTISPECIES: molybdopterin-binding protein [Actinomycetaceae]

Protein Classification

TOBE domain-containing protein( domain architecture ID 10007583)

TOBE (Transport-associated OB) domain-containing protein is also known as molybdopterin-binding protein that may be involved in the recognition of small ligands such as molybdenum and sulfate

CATH:  2.40.50.100
Gene Ontology:  GO:0015689
PubMed:  8458342
SCOP:  4000175

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MopI COG3585
Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];
10-128 8.96e-16

Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];


:

Pssm-ID: 442804 [Multi-domain]  Cd Length: 141  Bit Score: 68.56  E-value: 8.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736488199  10 ATLLGVSTDTVRRLVEDGTIKGTRQDGRILIDGKSLVDYIRQIAAQDERSTHGTEVNSIRNQLTGIVTDITSDKVMTRVE 89
Cdd:COG3585   18 GGVVNEVVLLLLGGGTIIAAITTASSAELLGLVGGKEVAALKKASVVILATDDAMKLSARNQLKGTVTRIERGAVNSEVV 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 736488199  90 M-ICGPFRIVSLISTEAAQEMKLEVGSLAVAGVKSTNVSV 128
Cdd:COG3585   98 LdLGGGTTLTAVITNESVEELGLKEGDEVTALFKASSVIL 137
 
Name Accession Description Interval E-value
MopI COG3585
Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];
10-128 8.96e-16

Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];


Pssm-ID: 442804 [Multi-domain]  Cd Length: 141  Bit Score: 68.56  E-value: 8.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736488199  10 ATLLGVSTDTVRRLVEDGTIKGTRQDGRILIDGKSLVDYIRQIAAQDERSTHGTEVNSIRNQLTGIVTDITSDKVMTRVE 89
Cdd:COG3585   18 GGVVNEVVLLLLGGGTIIAAITTASSAELLGLVGGKEVAALKKASVVILATDDAMKLSARNQLKGTVTRIERGAVNSEVV 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 736488199  90 M-ICGPFRIVSLISTEAAQEMKLEVGSLAVAGVKSTNVSV 128
Cdd:COG3585   98 LdLGGGTTLTAVITNESVEELGLKEGDEVTALFKASSVIL 137
HTH_17 pfam12728
Helix-turn-helix domain; This domain is a DNA-binding helix-turn-helix domain.
 4-51 8.59e-09

Helix-turn-helix domain; This domain is a DNA-binding helix-turn-helix domain.


Pssm-ID: 463684 [Multi-domain]  Cd Length: 51  Bit Score: 48.23  E-value: 8.59e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 736488199    4 LRVSNVATLLGVSTDTVRRLVEDGTIKGTRQDGRILIDGKSLVDYIRQ 51
Cdd:pfam12728   2 LTVEEAAELLGVSRRTVYRLIRSGELPAAKIGRRWRIRKSDLEEWLER 49
Mop TIGR00638
molybdenum-pterin binding domain; This model describes a multigene family of molybdenum-pterin ...
 67-131 2.05e-07

molybdenum-pterin binding domain; This model describes a multigene family of molybdenum-pterin binding proteins of about 70 amino acids in Clostridium pasteurianum, as a tandemly-repeated domain C-terminal to an unrelated domain in ModE, a molybdate transport gene repressor of E. coli, and in single or tandemly paired domains in several related proteins. [Transport and binding proteins, Anions]


Pssm-ID: 273189 [Multi-domain]  Cd Length: 69  Bit Score: 45.04  E-value: 2.05e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736488199   67 SIRNQLTGIVTDITSDKVMTRVEM-ICGPFRIVSLISTEAAQEMKLEVGSLAVAGVKSTNVSVSLP 131
Cdd:TIGR00638   4 SARNQLKGKVVAIEDGDVNAEVDLlLGGGTKLTAVITLESVAELGLKPGKEVYAVIKAPWVILAVD 69
HTH_MerR-trunc cd04762
Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Proteins in this family ...
 4-45 4.14e-05

Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Proteins in this family mostly have a truncated helix-turn-helix (HTH) MerR-like domain. They lack a portion of the C-terminal region, called Wing 2 and the long dimerization helix that is typically present in MerR-like proteins. These truncated domains are found in response regulator receiver (REC) domain proteins (i.e., CheY), cytosine-C5 specific DNA methylases, IS607 transposase-like proteins, and RacA, a bacterial protein that anchors chromosomes to cell poles.


Pssm-ID: 133390 [Multi-domain]  Cd Length: 49  Bit Score: 38.72  E-value: 4.14e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 736488199   4 LRVSNVATLLGVSTDTVRRLVEDGTIKGTRQD-GRILIDGKSL 45
Cdd:cd04762    1 LTTKEAAELLGVSPSTLRRWVKEGKLKAIRTPgGHRRFPEEDL 43
 
Name Accession Description Interval E-value
MopI COG3585
Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];
10-128 8.96e-16

Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];


Pssm-ID: 442804 [Multi-domain]  Cd Length: 141  Bit Score: 68.56  E-value: 8.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736488199  10 ATLLGVSTDTVRRLVEDGTIKGTRQDGRILIDGKSLVDYIRQIAAQDERSTHGTEVNSIRNQLTGIVTDITSDKVMTRVE 89
Cdd:COG3585   18 GGVVNEVVLLLLGGGTIIAAITTASSAELLGLVGGKEVAALKKASVVILATDDAMKLSARNQLKGTVTRIERGAVNSEVV 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 736488199  90 M-ICGPFRIVSLISTEAAQEMKLEVGSLAVAGVKSTNVSV 128
Cdd:COG3585   98 LdLGGGTTLTAVITNESVEELGLKEGDEVTALFKASSVIL 137
HTH_17 pfam12728
Helix-turn-helix domain; This domain is a DNA-binding helix-turn-helix domain.
 4-51 8.59e-09

Helix-turn-helix domain; This domain is a DNA-binding helix-turn-helix domain.


Pssm-ID: 463684 [Multi-domain]  Cd Length: 51  Bit Score: 48.23  E-value: 8.59e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 736488199    4 LRVSNVATLLGVSTDTVRRLVEDGTIKGTRQDGRILIDGKSLVDYIRQ 51
Cdd:pfam12728   2 LTVEEAAELLGVSRRTVYRLIRSGELPAAKIGRRWRIRKSDLEEWLER 49
Mop TIGR00638
molybdenum-pterin binding domain; This model describes a multigene family of molybdenum-pterin ...
 67-131 2.05e-07

molybdenum-pterin binding domain; This model describes a multigene family of molybdenum-pterin binding proteins of about 70 amino acids in Clostridium pasteurianum, as a tandemly-repeated domain C-terminal to an unrelated domain in ModE, a molybdate transport gene repressor of E. coli, and in single or tandemly paired domains in several related proteins. [Transport and binding proteins, Anions]


Pssm-ID: 273189 [Multi-domain]  Cd Length: 69  Bit Score: 45.04  E-value: 2.05e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736488199   67 SIRNQLTGIVTDITSDKVMTRVEM-ICGPFRIVSLISTEAAQEMKLEVGSLAVAGVKSTNVSVSLP 131
Cdd:TIGR00638   4 SARNQLKGKVVAIEDGDVNAEVDLlLGGGTKLTAVITLESVAELGLKPGKEVYAVIKAPWVILAVD 69
TOBE pfam03459
TOBE domain; The TOBE domain (Transport-associated OB) always occurs as a dimer as the ...
 68-126 1.18e-05

TOBE domain; The TOBE domain (Transport-associated OB) always occurs as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum and sulfate. Found in ABC transporters immediately after the ATPase domain.


Pssm-ID: 427310 [Multi-domain]  Cd Length: 60  Bit Score: 40.34  E-value: 1.18e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 736488199   68 IRNQLTGIVTDITSDKVMTRVEMICGP-FRIVSLISTEAAQEMKLEVGSLAVAGVKSTNV 126
Cdd:pfam03459   1 ARNQLPGTVTVIEPLGSEVEVRVDLGGgLTLTARITRDSAEELGLAPGDEVWALIKATKV 60
excise TIGR01764
DNA binding domain, excisionase family; An excisionase, or Xis protein, is a small protein ...
 4-51 2.77e-05

DNA binding domain, excisionase family; An excisionase, or Xis protein, is a small protein that binds and promotes excisive recombination; it is not enzymatically active. This model represents a number of putative excisionases and related proteins from temperate phage, plasmids, and transposons, as well as DNA binding domains of other proteins, such as a DNA modification methylase. This model identifies mostly small proteins and N-terminal regions of large proteins, but some proteins appear to have two copies. This domain appears similar, in both sequence and predicted secondary structure (PSIPRED) to the MerR family of transcriptional regulators (pfam00376). [Unknown function, General]


Pssm-ID: 200128  Cd Length: 49  Bit Score: 39.12  E-value: 2.77e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 736488199    4 LRVSNVATLLGVSTDTVRRLVEDGTIKGTRQDGRILIDGKSLVDYIRQ 51
Cdd:TIGR01764   2 LTVEEAAEYLGVSKSTVYRLIEEGELPAYRVGRHYRIPREDVDEYLEQ 49
HTH_MerR-trunc cd04762
Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Proteins in this family ...
 4-45 4.14e-05

Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Proteins in this family mostly have a truncated helix-turn-helix (HTH) MerR-like domain. They lack a portion of the C-terminal region, called Wing 2 and the long dimerization helix that is typically present in MerR-like proteins. These truncated domains are found in response regulator receiver (REC) domain proteins (i.e., CheY), cytosine-C5 specific DNA methylases, IS607 transposase-like proteins, and RacA, a bacterial protein that anchors chromosomes to cell poles.


Pssm-ID: 133390 [Multi-domain]  Cd Length: 49  Bit Score: 38.72  E-value: 4.14e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 736488199   4 LRVSNVATLLGVSTDTVRRLVEDGTIKGTRQD-GRILIDGKSL 45
Cdd:cd04762    1 LTTKEAAELLGVSPSTLRRWVKEGKLKAIRTPgGHRRFPEEDL 43
COG2452 COG2452
Predicted site-specific integrase-resolvase [Mobilome: prophages, transposons];
4-66 4.09e-03

Predicted site-specific integrase-resolvase [Mobilome: prophages, transposons];


Pssm-ID: 441988 [Multi-domain]  Cd Length: 178  Bit Score: 35.35  E-value: 4.09e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 736488199   4 LRVSNVATLLGVSTDTVRRLVEDGTIKGTRQD-GRILIDGKSLVDYIRQIAAQDERSTHGTEVN 66
Cdd:COG2452    1 LTPGEAAELLGVSPKTLRRWEKEGKLPAIRTPgGHRRYPESEVERLERRTVIYARVSSADQKDD 64
AlpA COG3311
DNA-binding transcriptional regulator AlpA [Transcription, Mobilome: prophages, transposons];
4-29 8.74e-03

DNA-binding transcriptional regulator AlpA [Transcription, Mobilome: prophages, transposons];


Pssm-ID: 442540 [Multi-domain]  Cd Length: 64  Bit Score: 32.59  E-value: 8.74e-03
                         10        20
                 ....*....|....*....|....*.
gi 736488199   4 LRVSNVATLLGVSTDTVRRLVEDGTI 29
Cdd:COG3311    9 LRLKEVAELLGVSRSTIYRLIKKGEF 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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