|
Name |
Accession |
Description |
Interval |
E-value |
| LptD |
COG1452 |
LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall ... |
92-795 |
0e+00 |
|
LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441061 [Multi-domain] Cd Length: 702 Bit Score: 566.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 92 EAVDPEQATSTVTADYGHY-NPNGDSYLEGNVVIDQQGRQIRADKVTIDQTQTYAKAQGRVQLAQAGLLSQSDDINYNLK 170
Cdd:COG1452 12 DLAPDDDAPVLIEADSLEYdQDDGTVTAEGNVEIRQGDRRLKADRVTYDQKTGTVTAEGNVRLTDGGNVLTGDEAELNLD 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 171 TQQGDLNNSFYIAEQQHAHGRADKIAKTSTDTVELENATYTTCPPDEkPTWKIQADRIKLNQETGRGETRNTKLYVKEVP 250
Cdd:COG1452 92 TKDGFIENARYQLVDRGGRGAAERIKRTGDNRTRLENATYTTCPPGD-PDWQIRASRIILDQEEKVGTARNARLEIKGVP 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 251 VLALPYFNFPIDDRRTTGILTPSFGFTNDGGLELGVPVYLNLAPNYDATITPRFIADRGAMLNGEFRYLTENfGYGQIW- 329
Cdd:COG1452 171 VFYLPYLSFPDPDKRKSGFLIPSFGSSSRLGFELSLPYYWNIAPNYDATLTPRYMSKRGLQLGGEYRYLFKS-GSGELSi 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 330 -GSILPSDKSYNDEDRKDLHFRHDWQINEQFSTNLEYNYASDKDFFSDLNNSPDSKTDLNLRRAWELNyKNGLPGLKAQL 408
Cdd:COG1452 250 rGEYLPDDRLGDNDDRGLLRWQHSFDLNKGWRFGADVNRVSDDDYLRDFDSSLGSSSDDYLTSSASLS-RTYGDNWNLSL 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 409 KVEDFQTLDPDvaDEDRPYARLPQFLVNYKTGNPLGWQFEANHDTAYFKKDignlhPSLDSYEPSGTRIYNDLAVRYNYR 488
Cdd:COG1452 329 RAQHFQTLRDS--DDDSPYQRLPQLDFNYVYRPLLGGEFSLDAEATNFTRD-----DSDFQDGPDGTRLHLEPSWSLPLS 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 489 TP-GAFLIPQASLRnvNTFYDQDTRDNLDSINSSSEStsiVVPEFTLDAGLIFEKE----GRYLQTLTPRLFYAYAPYEN 563
Cdd:COG1452 402 RPgGLFLTPKAGLR--ATAYQLDNDSDPDTLDGSVSR---VLPTFSLDSGLPFERDfslgGGGTQTLEPRLQYLYVPYRD 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 564 QEDQPNFDSVNASISYDQLFSPRRFYGHDRLEDNNFASVGLSYSLFDDI-GLERLRASVGQSFFFEDRrvnleRDLDEYD 642
Cdd:COG1452 477 QSDIPNFDSALLDFDYANLFSDNRFSGYDRIEDGNQLTLGLTSRLLDKDgGRERLRLSVGQSYYFADQ-----RTLADDS 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 643 RESHTGPVV-QLTSQLSENLRLGFNSAWMSNGDNAQR-DVQAYYTGEKGNLyNIGYFYRQDIAD--RQKSYDQVVGSFIQ 718
Cdd:COG1452 552 GSTKLSDLVaEASLRPNDGLSLTARAQYDPYTGRVNRgNAGLRYRPDRRNL-NLGYRYLRDDPDygYSDDIEQLDLSGSW 630
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736576230 719 PVSNNWRLIGHAQYDMDNHVAREYLLGVNYESCCWGVSVYGRSYYNDLDDvneagVKPKRMIMAEVSLRGLGGFNNK 795
Cdd:COG1452 631 PLTDNWSVVGRYRYDLTDNRLVETLLGLEYDDCCWALRLVYRRYYTSGSD-----LEYDTSFFFQLELKGLGSLGSN 702
|
|
| PRK03761 |
PRK03761 |
LPS assembly outer membrane complex protein LptD; Provisional |
95-807 |
2.90e-95 |
|
LPS assembly outer membrane complex protein LptD; Provisional
Pssm-ID: 235158 [Multi-domain] Cd Length: 778 Bit Score: 314.94 E-value: 2.90e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 95 DPEQATSTVTADYGHYNPNGDSYLEGNVVIDQQGRQIRADKVTIDQTQ--------TYAKAQGRVQLAQAGLLSQSDDIN 166
Cdd:PRK03761 45 DPNQLPVTIEADHAEANYPDDAVYTGNVDIKQGNSRLTADEVQLHQQEnpgqaepvRTVDALGNVHYDDNQIILKGPKAW 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 167 YNLKTQQGDLNNSFYIAEQQHAHGRADKIAKTSTDTVE-LENATYTTCPPDEKpTWKIQADRIKLNQETGRGETRNTKLY 245
Cdd:PRK03761 125 SNLNTKDTNVWNGDYQMVGRQGRGKADLMKQRGQNRYTiLENGSFTSCLPGDN-SWSVVGSEIIHDREEEVAEIWNARFK 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 246 VKEVPVLALPYFNFPIDDRRTTGILTPSFGFTNDGGLELGVPVYLNLAPNYDATITPRFIADRGAMLNGEFRYLTEnFGY 325
Cdd:PRK03761 204 VGGVPVFYSPYLQLPIGDKRRSGFLIPNAKYSSKNGFEFELPYYWNIAPNYDATITPHYMSRRGWQWENEFRYLTQ-AGA 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 326 GQIWGSILPSDKSYNDEDRKD------LHFRHDWQINEQFSTNLEYNYASDKDFFSDLNNSPDSKTDLNLRRAWELNYKN 399
Cdd:PRK03761 283 GLMAGEYLPSDRVYEDEPNDDnssrwlFYWNHSGVMDQVWRFNVDYTKVSDPRYFTDFDSKYGSSTDGYATQKFSVGYAQ 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 400 glPGLKAQLKVEDFQTLDpdvADEDRPYARLPQFLVNYKTgNPLGW-QFEANHDTAYFKKDignlhpslDSYEPSGTRIY 478
Cdd:PRK03761 363 --QNWNATLSTKQFQVFD---EQNNSPYRAEPQLDFNYYQ-NDLGPfDFRLYGQAVRFTND--------NKNMPEATRVH 428
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 479 NDLAVRYNYRTPGAFLIPQASLrnVNTFYDQDTRDNLDSINSSSESTSI--VVPEFTLDAGLIFEKE----GRYLQTLTP 552
Cdd:PRK03761 429 LEPTLNLPLSNRWGSLNTEAKL--LATHYQQDNLDWYNSNNTTKLEESVnrVIPQFKVDGKMVFERDmdlaPGYTQTLEP 506
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 553 RLFYAYAPYENQEDQPNFDSVNASISYDQLFSPRRFYGHDRLEDNNFASVGLSYSLFDDIGLERLRASVGQSFFFEDRRV 632
Cdd:PRK03761 507 RVQYLYVPYRDQSNIYNYDSTLLQSDYYGLFRDRTYSGLDRIASANQVTTGVTTRFYDDAAVERFNISVGQIYYFTPSRT 586
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 633 NLERDLDEYDRES------------------HTGpvVQLTSQLSeNLRLGfNSA--WMSNGDN-AQ---RDVQAYYTGEK 688
Cdd:PRK03761 587 GDNNTWENDDKTGssvwagdtywrisdrwglRGG--IQYDTRLD-SVALA-NSSleYRRDEDRlIQlnyRYASPEYIQAT 662
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 689 GNLYNIGYFYRQDIAdrqksydQV--VGSFiqPVSNNWRLIGHAQYDMDNHVAREYLLGVNYESCCWGVSVYgrsYYNDL 766
Cdd:PRK03761 663 LPSYYSAEIYQQGIS-------QVgaVASW--PIADRWSIVGAYYYDTKANKPAEQLLGLQYNSCCWAIGVG---YERKL 730
|
730 740 750 760
....*....|....*....|....*....|....*....|....*
gi 736576230 767 DDVNEAGVKPK--RMIMAEVSLRGLGGfNNKL--ASLLENRILGF 807
Cdd:PRK03761 731 TGWDNDKQHSVydNKIGFNIELRGLSS-NYGLgtQEMLRSNILPY 774
|
|
| LptD |
pfam04453 |
LPS transport system D; Lipopolysaccharide (LPS) is essential for most Gram-negative bacteria ... |
342-724 |
5.30e-79 |
|
LPS transport system D; Lipopolysaccharide (LPS) is essential for most Gram-negative bacteria and has crucial roles in protection of the bacteria from harsh environments and toxic compounds, including antibiotics. This family includes members such as LPTD found in Shigella flexneri and Yersinia pestis. Structural analysis indicates that LptD forms a novel 26-stranded beta-barrel. It interacts with LPTE where LptE adopts a roll-like structure located inside the barrel of LptD. The LPS translocon LptD is unable to fold properly in the absence of LptE and the two proteins form a unique barrel and plug architecture for LPS transport and insertion. LptD is an essential outer membrane protein that mediates the final transport of lipopolysaccharide (LPS) to outer leaflet. It has been suggested that LptD is a promising target for the development of effective vaccines and antibody-based therapies to control Vibrio infection.
Pssm-ID: 427958 Cd Length: 384 Bit Score: 259.64 E-value: 5.30e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 342 EDRKDLHFRHDWQINEQFSTNLEYNYASDKDFFSDLNNSPDSKTDLNLRRAWELNYKNGlpGLKAQLKVEDFQTLDPDVA 421
Cdd:pfam04453 1 KNRGYFNASHQFILNDNWSFGVDYNYVSDKNYFRDYDSNIGLVSQTYLLRQGRLSYRND--NWDFSLRVQDYQTLDPTII 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 422 DEDRPYARLPQFLVNYKTGNPL--GWQFEANHDTAYFKKDignlhpslDSYEPSGTRIYNDLAVRYNYRTPGAFLIPQAS 499
Cdd:pfam04453 79 SNDTPYQRLPQLDYNYYKPDPGfgGLDFSFDSQYVRFSRD--------DGQQPTGTRLHLEPEISLPFTNPWGFLTPELK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 500 LRNvnTFYDQDTRDNLDSINSSSESTSI--VVPEFTLDAGLIFEKE----GRYLQTLTPRLFYAYAPYENQEDQPNFDSV 573
Cdd:pfam04453 151 LRG--TAYDLDVDLGPGENATGGLDSSVtrVLPTFSLDSGLPFERDttlfGDYTQTLEPRAQYLYVPYRDQNNLPNYDSS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 574 NASISYDQLFSPRRFYGHDRLEDNNFASVGLSYSLFD-DIGLERLRASVGQSFFFEDRRVNLERDLDeYDRESHTGPVVQ 652
Cdd:pfam04453 229 SLDFDYTNLFRDNRFSGYDRIEDANQLTYGVTSRFFDaNGGFERLRLSVGQSFYFTDRRVFLIGDES-GLTRRSSDLVAE 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736576230 653 LTSQLSENLRLGFNSAWMSNGDNAQR-DVQAYYTGEKGNLYNIGYFYRQDIADRQKS----YDQVVGSFIQPVSNNW 724
Cdd:pfam04453 308 LSFSPNRGLNLSASIQYDPYTNNFERgEVGLSYRPDRGNSINLGYRYRRNDPEYQNAtnngISQIGLSAQWPLADNW 384
|
|
| YrbK |
COG3117 |
Lipopolysaccharide export system protein LptC [Cell wall/membrane/envelope biogenesis]; |
1-173 |
5.08e-12 |
|
Lipopolysaccharide export system protein LptC [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442351 [Multi-domain] Cd Length: 183 Bit Score: 65.36 E-value: 5.08e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 1 MKHQFKYnplATAILTLLCGSSITGYAAENDSSTNTTPQQNNSlqeSYPGEAFYSQYYVDK-------SSPEAQQRQGQy 73
Cdd:COG3117 1 MSKRLRR---LLLLLLLLLLALLTWWLEQPEPPPPAAVQPHEP---DYTAENFTLTRFDADgrlsyrlTADKMEHYPDD- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 74 lssaycKGTWITpvSPEVEAVDPEQATSTVTADYGHYNPNGDS-YLEGNVVI-----DQQGRQIRADKVTIDQTQTYAKA 147
Cdd:COG3117 74 ------DTTELT--NPVLTLYDEDGPPWTITADRGKLNKDGKElYLYGNVVVtrlagAGPALTLTTEELTVDPDTQDAST 145
|
170 180
....*....|....*....|....*.
gi 736576230 148 QGRVQLAQAGLLSQSDDINYNLKTQQ 173
Cdd:COG3117 146 DDPVTITGGGSTITGVGMRANLRTQT 171
|
|
| LptC_YrbK |
TIGR04409 |
LPS export ABC transporter periplasmic protein LptC; Members of this family are LptC, a ... |
82-178 |
2.26e-05 |
|
LPS export ABC transporter periplasmic protein LptC; Members of this family are LptC, a periplasmic protein tethered to the inner membrane in the lipopolysaccharide (LPS)exporter transenvelope complex (Lpt), which is responsible for conducting LPS to the outer leaflet of the outer membrane in most Gram-negative bacteria. LptC is homologous to LptA, another member of the transenvelope complex. Genes lptC and lptA are often adjacent. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other]
Pssm-ID: 275202 [Multi-domain] Cd Length: 180 Bit Score: 45.70 E-value: 2.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 82 TWITpvSPEVEAVDPE-QATSTVTADYGHYNPNGDS-YLEGNVVI-----DQQGRQIRADKVTIDQTQTYAKAQGRVQLA 154
Cdd:TIGR04409 73 TEFT--NPVLILFDEDgKPTWTITADRAKLNKDGKElYLYGNVRVtrlagDGPPQTLTTENLTVDLDTQDATSDQPVTIT 150
|
90 100
....*....|....*....|....
gi 736576230 155 QAGLLSQSDDINYNLKTQQGDLNN 178
Cdd:TIGR04409 151 GPGFTITGVGMKANLKTGTAELLS 174
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LptD |
COG1452 |
LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall ... |
92-795 |
0e+00 |
|
LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441061 [Multi-domain] Cd Length: 702 Bit Score: 566.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 92 EAVDPEQATSTVTADYGHY-NPNGDSYLEGNVVIDQQGRQIRADKVTIDQTQTYAKAQGRVQLAQAGLLSQSDDINYNLK 170
Cdd:COG1452 12 DLAPDDDAPVLIEADSLEYdQDDGTVTAEGNVEIRQGDRRLKADRVTYDQKTGTVTAEGNVRLTDGGNVLTGDEAELNLD 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 171 TQQGDLNNSFYIAEQQHAHGRADKIAKTSTDTVELENATYTTCPPDEkPTWKIQADRIKLNQETGRGETRNTKLYVKEVP 250
Cdd:COG1452 92 TKDGFIENARYQLVDRGGRGAAERIKRTGDNRTRLENATYTTCPPGD-PDWQIRASRIILDQEEKVGTARNARLEIKGVP 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 251 VLALPYFNFPIDDRRTTGILTPSFGFTNDGGLELGVPVYLNLAPNYDATITPRFIADRGAMLNGEFRYLTENfGYGQIW- 329
Cdd:COG1452 171 VFYLPYLSFPDPDKRKSGFLIPSFGSSSRLGFELSLPYYWNIAPNYDATLTPRYMSKRGLQLGGEYRYLFKS-GSGELSi 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 330 -GSILPSDKSYNDEDRKDLHFRHDWQINEQFSTNLEYNYASDKDFFSDLNNSPDSKTDLNLRRAWELNyKNGLPGLKAQL 408
Cdd:COG1452 250 rGEYLPDDRLGDNDDRGLLRWQHSFDLNKGWRFGADVNRVSDDDYLRDFDSSLGSSSDDYLTSSASLS-RTYGDNWNLSL 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 409 KVEDFQTLDPDvaDEDRPYARLPQFLVNYKTGNPLGWQFEANHDTAYFKKDignlhPSLDSYEPSGTRIYNDLAVRYNYR 488
Cdd:COG1452 329 RAQHFQTLRDS--DDDSPYQRLPQLDFNYVYRPLLGGEFSLDAEATNFTRD-----DSDFQDGPDGTRLHLEPSWSLPLS 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 489 TP-GAFLIPQASLRnvNTFYDQDTRDNLDSINSSSEStsiVVPEFTLDAGLIFEKE----GRYLQTLTPRLFYAYAPYEN 563
Cdd:COG1452 402 RPgGLFLTPKAGLR--ATAYQLDNDSDPDTLDGSVSR---VLPTFSLDSGLPFERDfslgGGGTQTLEPRLQYLYVPYRD 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 564 QEDQPNFDSVNASISYDQLFSPRRFYGHDRLEDNNFASVGLSYSLFDDI-GLERLRASVGQSFFFEDRrvnleRDLDEYD 642
Cdd:COG1452 477 QSDIPNFDSALLDFDYANLFSDNRFSGYDRIEDGNQLTLGLTSRLLDKDgGRERLRLSVGQSYYFADQ-----RTLADDS 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 643 RESHTGPVV-QLTSQLSENLRLGFNSAWMSNGDNAQR-DVQAYYTGEKGNLyNIGYFYRQDIAD--RQKSYDQVVGSFIQ 718
Cdd:COG1452 552 GSTKLSDLVaEASLRPNDGLSLTARAQYDPYTGRVNRgNAGLRYRPDRRNL-NLGYRYLRDDPDygYSDDIEQLDLSGSW 630
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736576230 719 PVSNNWRLIGHAQYDMDNHVAREYLLGVNYESCCWGVSVYGRSYYNDLDDvneagVKPKRMIMAEVSLRGLGGFNNK 795
Cdd:COG1452 631 PLTDNWSVVGRYRYDLTDNRLVETLLGLEYDDCCWALRLVYRRYYTSGSD-----LEYDTSFFFQLELKGLGSLGSN 702
|
|
| PRK03761 |
PRK03761 |
LPS assembly outer membrane complex protein LptD; Provisional |
95-807 |
2.90e-95 |
|
LPS assembly outer membrane complex protein LptD; Provisional
Pssm-ID: 235158 [Multi-domain] Cd Length: 778 Bit Score: 314.94 E-value: 2.90e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 95 DPEQATSTVTADYGHYNPNGDSYLEGNVVIDQQGRQIRADKVTIDQTQ--------TYAKAQGRVQLAQAGLLSQSDDIN 166
Cdd:PRK03761 45 DPNQLPVTIEADHAEANYPDDAVYTGNVDIKQGNSRLTADEVQLHQQEnpgqaepvRTVDALGNVHYDDNQIILKGPKAW 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 167 YNLKTQQGDLNNSFYIAEQQHAHGRADKIAKTSTDTVE-LENATYTTCPPDEKpTWKIQADRIKLNQETGRGETRNTKLY 245
Cdd:PRK03761 125 SNLNTKDTNVWNGDYQMVGRQGRGKADLMKQRGQNRYTiLENGSFTSCLPGDN-SWSVVGSEIIHDREEEVAEIWNARFK 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 246 VKEVPVLALPYFNFPIDDRRTTGILTPSFGFTNDGGLELGVPVYLNLAPNYDATITPRFIADRGAMLNGEFRYLTEnFGY 325
Cdd:PRK03761 204 VGGVPVFYSPYLQLPIGDKRRSGFLIPNAKYSSKNGFEFELPYYWNIAPNYDATITPHYMSRRGWQWENEFRYLTQ-AGA 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 326 GQIWGSILPSDKSYNDEDRKD------LHFRHDWQINEQFSTNLEYNYASDKDFFSDLNNSPDSKTDLNLRRAWELNYKN 399
Cdd:PRK03761 283 GLMAGEYLPSDRVYEDEPNDDnssrwlFYWNHSGVMDQVWRFNVDYTKVSDPRYFTDFDSKYGSSTDGYATQKFSVGYAQ 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 400 glPGLKAQLKVEDFQTLDpdvADEDRPYARLPQFLVNYKTgNPLGW-QFEANHDTAYFKKDignlhpslDSYEPSGTRIY 478
Cdd:PRK03761 363 --QNWNATLSTKQFQVFD---EQNNSPYRAEPQLDFNYYQ-NDLGPfDFRLYGQAVRFTND--------NKNMPEATRVH 428
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 479 NDLAVRYNYRTPGAFLIPQASLrnVNTFYDQDTRDNLDSINSSSESTSI--VVPEFTLDAGLIFEKE----GRYLQTLTP 552
Cdd:PRK03761 429 LEPTLNLPLSNRWGSLNTEAKL--LATHYQQDNLDWYNSNNTTKLEESVnrVIPQFKVDGKMVFERDmdlaPGYTQTLEP 506
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 553 RLFYAYAPYENQEDQPNFDSVNASISYDQLFSPRRFYGHDRLEDNNFASVGLSYSLFDDIGLERLRASVGQSFFFEDRRV 632
Cdd:PRK03761 507 RVQYLYVPYRDQSNIYNYDSTLLQSDYYGLFRDRTYSGLDRIASANQVTTGVTTRFYDDAAVERFNISVGQIYYFTPSRT 586
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 633 NLERDLDEYDRES------------------HTGpvVQLTSQLSeNLRLGfNSA--WMSNGDN-AQ---RDVQAYYTGEK 688
Cdd:PRK03761 587 GDNNTWENDDKTGssvwagdtywrisdrwglRGG--IQYDTRLD-SVALA-NSSleYRRDEDRlIQlnyRYASPEYIQAT 662
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 689 GNLYNIGYFYRQDIAdrqksydQV--VGSFiqPVSNNWRLIGHAQYDMDNHVAREYLLGVNYESCCWGVSVYgrsYYNDL 766
Cdd:PRK03761 663 LPSYYSAEIYQQGIS-------QVgaVASW--PIADRWSIVGAYYYDTKANKPAEQLLGLQYNSCCWAIGVG---YERKL 730
|
730 740 750 760
....*....|....*....|....*....|....*....|....*
gi 736576230 767 DDVNEAGVKPK--RMIMAEVSLRGLGGfNNKL--ASLLENRILGF 807
Cdd:PRK03761 731 TGWDNDKQHSVydNKIGFNIELRGLSS-NYGLgtQEMLRSNILPY 774
|
|
| PRK04423 |
PRK04423 |
LPS-assembly protein LptD; |
119-808 |
4.81e-84 |
|
LPS-assembly protein LptD;
Pssm-ID: 235297 [Multi-domain] Cd Length: 798 Bit Score: 285.23 E-value: 4.81e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 119 EGNVVIDQQGRQIRADKVTID-QTQTYAkAQGRVQLAQAGLLSQSDDINYNLKTQQGDLNNSFYIAEQQHAHGRADKIaK 197
Cdd:PRK04423 77 QGNVALKRGDQFLGADNLRMDtETGNYI-AEGNVRYQDTSIRMVADRAEGNQDTDTHKITNIQYQLVSRRGNGDAESV-D 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 198 TSTDTVELENATYTTCPPDEkPTWKIQADRIKLNQETGRGETRNTKLYVKEVPVLALPYFNFPIDDRRTTGILTPSFGFT 277
Cdd:PRK04423 155 LQGQVGQMHRSTYTTCDPSQ-PIWRLRAPEIDVDNDEGFGTARNAVLQIGKVPVLYFPWFKFPIDDRRQTGLLFPQFGLS 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 278 NDGGLELGVPVYLNLAPNYDATITPRFIADRGAMLNGEFRYLTENfGYGQIWGSILPSDKsYNDEDRKDLHFRHDWQINE 357
Cdd:PRK04423 234 GRNGFDYLQPIYLNLAPNYDATLLPRYMSKRGFMFGTEFRYLYDG-GRGEVTGNYLPNDK-LRDKDRGRVFYSGYHNVNS 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 358 QFSTNLEYNYASDKDFFSDLNNSPdsktdLNLRRAWELNYKNGLPGL----KAQLKVEDFQTLDPDVADEDRPYARLPQF 433
Cdd:PRK04423 312 HWQARASLSWVSDTRYVEDFTSRL-----NGMGSASSLQSTVGIYGTgetwTAGLMADRWQLTDYTLDERALPYNRQPRA 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 434 LVNYKtgNPLGWQFEAN---------HDTAYFK------KDIGNLHPSLDSYEP-SGTRIynDLAVRYNYRTPGA--FLI 495
Cdd:PRK04423 387 YFNWE--KPVFGIFEAGvyaeavrftHDDSYLVqppndgDDDNYVRTGIVNREYgSGSRL--DVKPYVSMPLSGAawFVT 462
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 496 PQASLRNVNTFYDQDTRDNLDSINSSSESTSIvvPEFTLDAGLIFEKEGR-----YLQTLTPRLFYAYAPYENQEDQPNF 570
Cdd:PRK04423 463 PTLAWRYTAYQLDSTLAETAPLTGDRSPSRSL--PIASLDAGLYFDRETSlfgtnYLNTLEPRLYYLYVPYRNQDDLPVF 540
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 571 DSVNASISYDQLFSPRRFYGHDRLEDNNFASVGLSYSLFD-DIGLERLRASVGQSFFFEDRRVNLErDLDEYDRESHTGP 649
Cdd:PRK04423 541 DTRPFTFSWGQLFRDSRYTGADRQNDANQLTLAVTSRWLRqDDGKEKLSLSAGQILYFDDSLVTIN-NSEQTIEQGKSAW 619
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 650 VVQLTSQLSENLRLGFNSAWmsnGDNAQRD----VQAYYTGEKGNLYNIGYFYRQDIADRQKSYDQVVGSFIQPVSNNWR 725
Cdd:PRK04423 620 VADANYMINDRWTLGATYQW---NPNSRREdlasLRTRYLLPNDGIINLAYRYRRNLIDNSDQLKQADFSFLYPINPRWS 696
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 726 LIGHAQYDMDNHVAREYLLGVNYESCCWGVSVYGRSYYNDLD-DVNEAgvkpkrmIMAEVSLRGLGGFNNKLASLLENRI 804
Cdd:PRK04423 697 AVGRYYYSLLDKKPLEIIGGVQWDSCCLAVRALVRRFVRNRDgEMDNS-------IQIEFVLKGLSSFGQDTDRTLRRAI 769
|
....
gi 736576230 805 LGFN 808
Cdd:PRK04423 770 LGYY 773
|
|
| LptD |
pfam04453 |
LPS transport system D; Lipopolysaccharide (LPS) is essential for most Gram-negative bacteria ... |
342-724 |
5.30e-79 |
|
LPS transport system D; Lipopolysaccharide (LPS) is essential for most Gram-negative bacteria and has crucial roles in protection of the bacteria from harsh environments and toxic compounds, including antibiotics. This family includes members such as LPTD found in Shigella flexneri and Yersinia pestis. Structural analysis indicates that LptD forms a novel 26-stranded beta-barrel. It interacts with LPTE where LptE adopts a roll-like structure located inside the barrel of LptD. The LPS translocon LptD is unable to fold properly in the absence of LptE and the two proteins form a unique barrel and plug architecture for LPS transport and insertion. LptD is an essential outer membrane protein that mediates the final transport of lipopolysaccharide (LPS) to outer leaflet. It has been suggested that LptD is a promising target for the development of effective vaccines and antibody-based therapies to control Vibrio infection.
Pssm-ID: 427958 Cd Length: 384 Bit Score: 259.64 E-value: 5.30e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 342 EDRKDLHFRHDWQINEQFSTNLEYNYASDKDFFSDLNNSPDSKTDLNLRRAWELNYKNGlpGLKAQLKVEDFQTLDPDVA 421
Cdd:pfam04453 1 KNRGYFNASHQFILNDNWSFGVDYNYVSDKNYFRDYDSNIGLVSQTYLLRQGRLSYRND--NWDFSLRVQDYQTLDPTII 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 422 DEDRPYARLPQFLVNYKTGNPL--GWQFEANHDTAYFKKDignlhpslDSYEPSGTRIYNDLAVRYNYRTPGAFLIPQAS 499
Cdd:pfam04453 79 SNDTPYQRLPQLDYNYYKPDPGfgGLDFSFDSQYVRFSRD--------DGQQPTGTRLHLEPEISLPFTNPWGFLTPELK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 500 LRNvnTFYDQDTRDNLDSINSSSESTSI--VVPEFTLDAGLIFEKE----GRYLQTLTPRLFYAYAPYENQEDQPNFDSV 573
Cdd:pfam04453 151 LRG--TAYDLDVDLGPGENATGGLDSSVtrVLPTFSLDSGLPFERDttlfGDYTQTLEPRAQYLYVPYRDQNNLPNYDSS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 574 NASISYDQLFSPRRFYGHDRLEDNNFASVGLSYSLFD-DIGLERLRASVGQSFFFEDRRVNLERDLDeYDRESHTGPVVQ 652
Cdd:pfam04453 229 SLDFDYTNLFRDNRFSGYDRIEDANQLTYGVTSRFFDaNGGFERLRLSVGQSFYFTDRRVFLIGDES-GLTRRSSDLVAE 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736576230 653 LTSQLSENLRLGFNSAWMSNGDNAQR-DVQAYYTGEKGNLYNIGYFYRQDIADRQKS----YDQVVGSFIQPVSNNW 724
Cdd:pfam04453 308 LSFSPNRGLNLSASIQYDPYTNNFERgEVGLSYRPDRGNSINLGYRYRRNDPEYQNAtnngISQIGLSAQWPLADNW 384
|
|
| YrbK |
COG3117 |
Lipopolysaccharide export system protein LptC [Cell wall/membrane/envelope biogenesis]; |
1-173 |
5.08e-12 |
|
Lipopolysaccharide export system protein LptC [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442351 [Multi-domain] Cd Length: 183 Bit Score: 65.36 E-value: 5.08e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 1 MKHQFKYnplATAILTLLCGSSITGYAAENDSSTNTTPQQNNSlqeSYPGEAFYSQYYVDK-------SSPEAQQRQGQy 73
Cdd:COG3117 1 MSKRLRR---LLLLLLLLLLALLTWWLEQPEPPPPAAVQPHEP---DYTAENFTLTRFDADgrlsyrlTADKMEHYPDD- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 74 lssaycKGTWITpvSPEVEAVDPEQATSTVTADYGHYNPNGDS-YLEGNVVI-----DQQGRQIRADKVTIDQTQTYAKA 147
Cdd:COG3117 74 ------DTTELT--NPVLTLYDEDGPPWTITADRGKLNKDGKElYLYGNVVVtrlagAGPALTLTTEELTVDPDTQDAST 145
|
170 180
....*....|....*....|....*.
gi 736576230 148 QGRVQLAQAGLLSQSDDINYNLKTQQ 173
Cdd:COG3117 146 DDPVTITGGGSTITGVGMRANLRTQT 171
|
|
| LptD_N |
pfam03968 |
LptA/(LptD N-terminal domain) LPS transport protein; This family of proteins are involved in ... |
102-236 |
7.16e-07 |
|
LptA/(LptD N-terminal domain) LPS transport protein; This family of proteins are involved in lipopolysaccharide transport across the gram negative inner and outer membranes. The type examples for this family are E. coli LptA and the N-terminal domain of LptD.
Pssm-ID: 427621 [Multi-domain] Cd Length: 113 Bit Score: 48.39 E-value: 7.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 102 TVTADYGHYN-PNGDSYLEGNVVIDQQGRQIRADKVTIdqtqTYAKAQGRVQLAQAgllSQSDDINYNLKTQQGDLnnsf 180
Cdd:pfam03968 1 EIEADNAELDdKKNVATFTGNVIVTQGTLTLRADKVIV----TQDKKKNGPERLEA---TGPATFRQKVDLVGRPI---- 69
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 736576230 181 yiaeqqhaHGRADKIAKTS-TDTVELE-NATYTtcppdeKPTWKIQADRIKLNQETGR 236
Cdd:pfam03968 70 --------RGKADRIEYDVaKDIIVLTgNARLT------QGGNSVRGDKITYDIKEQK 113
|
|
| LptC |
pfam06835 |
Lipopolysaccharide-assembly, LptC-related; This family consists of several related groups of ... |
82-178 |
1.67e-06 |
|
Lipopolysaccharide-assembly, LptC-related; This family consists of several related groups of proteins one of which is the LptC family. LptC is involved in lipopolysaccharide-assembly on the outer membrane of Gram-negative organizms. The lipopolysaccharide component of the outer bacterial membrane is transported form its source of origin to the outer membrane by a set of proteins constituting a transport machinery that is made up of LptA, LptB, LptC, LptD, LptE. LptC is located on the inner membrane side of the intermembrane space.
Pssm-ID: 429144 [Multi-domain] Cd Length: 175 Bit Score: 49.17 E-value: 1.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 82 TWITpvSPEVEAVDPEQATSTVTADYGHYNPNGDS-YLEGNVVI-----DQQGRQIRADKVTIDQTQTYAKAQGRVQLAQ 155
Cdd:pfam06835 68 TEFT--NPVLIIYQEGKPPWTVTAKRAKLNKDGKMlYLYGNVVItrladDSQLMTITTERLTVNLDTKDASTDDPVTITG 145
|
90 100
....*....|....*....|...
gi 736576230 156 AGLLSQSDDINYNLKTQQGDLNN 178
Cdd:pfam06835 146 PNFVTTGIGMKGNLKTGQAELLS 168
|
|
| LptC_YrbK |
TIGR04409 |
LPS export ABC transporter periplasmic protein LptC; Members of this family are LptC, a ... |
82-178 |
2.26e-05 |
|
LPS export ABC transporter periplasmic protein LptC; Members of this family are LptC, a periplasmic protein tethered to the inner membrane in the lipopolysaccharide (LPS)exporter transenvelope complex (Lpt), which is responsible for conducting LPS to the outer leaflet of the outer membrane in most Gram-negative bacteria. LptC is homologous to LptA, another member of the transenvelope complex. Genes lptC and lptA are often adjacent. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other]
Pssm-ID: 275202 [Multi-domain] Cd Length: 180 Bit Score: 45.70 E-value: 2.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 82 TWITpvSPEVEAVDPE-QATSTVTADYGHYNPNGDS-YLEGNVVI-----DQQGRQIRADKVTIDQTQTYAKAQGRVQLA 154
Cdd:TIGR04409 73 TEFT--NPVLILFDEDgKPTWTITADRAKLNKDGKElYLYGNVRVtrlagDGPPQTLTTENLTVDLDTQDATSDQPVTIT 150
|
90 100
....*....|....*....|....
gi 736576230 155 QAGLLSQSDDINYNLKTQQGDLNN 178
Cdd:TIGR04409 151 GPGFTITGVGMKANLKTGTAELLS 174
|
|
| LptA |
COG1934 |
Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis]; |
92-238 |
1.60e-04 |
|
Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441537 [Multi-domain] Cd Length: 164 Bit Score: 42.98 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 92 EAVDPEQATsTVTADYGHYN-PNGDSYLEGNVVIDQQGRQIRADKVTIDQTQ----TYAKAQGRVQLaqagllsqsddin 166
Cdd:COG1934 18 QKADRDQPI-EIEADRLEVDdKKGTAVFTGNVVVTQGTLTLRADKLVVYYDKaggiERIEATGNVTF------------- 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 736576230 167 ynlkTQQGDlnnsfyiaEQQHAHGRADKIA-KTSTDTVELE-NATYTTcPPDEkptwkIQADRIKLNQETGRGE 238
Cdd:COG1934 84 ----RQKRD--------GGQEVEATADRAEyDVATDTVVLTgNAVLTQ-GGNT-----VTGDRITYDLKTGRAT 139
|
|
| LptA |
COG1934 |
Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis]; |
102-152 |
3.89e-04 |
|
Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441537 [Multi-domain] Cd Length: 164 Bit Score: 41.83 E-value: 3.89e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 736576230 102 TVTADYGHYNPNGDSY-LEGNVVIDQQGRQIRADKVTIDQTQTYAKAQ-----GRVQ 152
Cdd:COG1934 94 EATADRAEYDVATDTVvLTGNAVLTQGGNTVTGDRITYDLKTGRATAEgggggGRVR 150
|
|
| LptD_2 |
pfam19838 |
LptD protein; This entry likely represents the LptD homolog of Bacteriodetes bacteria. LptD is ... |
239-318 |
5.95e-04 |
|
LptD protein; This entry likely represents the LptD homolog of Bacteriodetes bacteria. LptD is an essential outer membrane protein that mediates the final transport of lipopolysaccharide (LPS) to outer leaflet.
Pssm-ID: 466203 Cd Length: 474 Bit Score: 43.32 E-value: 5.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 239 TRNTKLYVKEVPV-LALPYFNFPI-DDRRTTGILTPSFGFTNDGGL---ELGvpVYLNLAPNYDATITPRFIADRGAMLN 313
Cdd:pfam19838 3 TGPANLYIEDVPTpLGLPFGFFPLtSGRRRSGIIIPTYGESNDRGFflrNGG--YYFAINDYFDLTLTGDIYTKGSWGLN 80
|
....*
gi 736576230 314 GEFRY 318
Cdd:pfam19838 81 AESRY 85
|
|
| outer_YhbN_LptA |
TIGR03002 |
lipopolysaccharide transport periplasmic protein LptA; Members of this protein family include ... |
102-172 |
3.27e-03 |
|
lipopolysaccharide transport periplasmic protein LptA; Members of this protein family include LptA (previously called YhbN). It was shown to be an essential protein in E. coli, implicated in cell envelope integrity, and to play a role in the delivery of LPS to the outer leaflet of the outer membrane. It works with LptB (formerly yhbG), a homolog of ABC transporter ATP-binding proteins, encoded by an adjacent gene. Numerous homologs in other Proteobacteria are found in a conserved location near lipopolysaccharide inner core biosynthesis genes. This family is related to organic solvent tolerance protein (OstA), though distantly. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other]
Pssm-ID: 274384 [Multi-domain] Cd Length: 142 Bit Score: 38.74 E-value: 3.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736576230 102 TVTADYGHYN-PNGDSYLEGNVVIDQQGRQIRADKVTIDQTQ----TYAKAQG-----RVQLAQ-AGLLSQSDDINYNLK 170
Cdd:TIGR03002 11 HIEADSQTLDdKKGVVTFTGNVVITQGTLKIRADKVVVTRNDaggiEKATATGkpatfRQKLDNgKEIEGQANRIEYDPA 90
|
..
gi 736576230 171 TQ 172
Cdd:TIGR03002 91 KD 92
|
|
| |
