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Conserved domains on  [gi|736618482|ref|WP_034626745|]
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pyruvate kinase [Cellulomonas cellasea]

Protein Classification

pyruvate kinase( domain architecture ID 11422070)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

CATH:  2.40.33.10|3.20.20.60|3.40.1380.20
EC:  2.7.1.40
Gene Ontology:  GO:0004743|GO:0006096|GO:0005524|GO:0030955|GO:0000287
PubMed:  2379684|12798932|10751408|31342570
SCOP:  4003255|4002474|4000500

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 1-467 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 729.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   1 MRRAKIVCTIGPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVRAAAQASGRSVAVLVDLQGPKIRLGRFAEG 80
Cdd:COG0469    2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  81 KHELAVGDTFTITTEDVPGTKELVSTTHKGLPNDARVGDPILIDDGRVLVRITDVDGPRVVTRVEVAGPVSNNKGLNLPG 160
Cdd:COG0469   82 PVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLPG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 161 VAVSVPAMSDKDEADLRWALRTGADIIALSFVRNASDYDDVRRIMEEEGRVLPVIAKIEKPQAVENLVEIIDAFDGIMVA 240
Cdd:COG0469  162 VGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMVA 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 241 RGDLGVELPLEQVPLVQKRAVELARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLDGADAVMLSGETSVGDYPIE 320
Cdd:COG0469  242 RGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPVE 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 321 AVRTMARIIENTEELGRERI---APLGSTPHTRGGAITRAAAEIGETLGVKYLVTFTQSGDSARRMSRLRSGIPLLAFTP 397
Cdd:COG0469  322 AVETMARIAEEAEKSLDYRRildRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALTP 401

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 398 ETQVRNVLSLSWGVQTYEVSQVESTDAMVKLVDATLRANGLAELGDYVVVVAGAPVGVVGSTNSIVVHKI 467
Cdd:COG0469  402 NERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
 
Name Accession Description Interval E-value
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 1-467 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 729.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   1 MRRAKIVCTIGPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVRAAAQASGRSVAVLVDLQGPKIRLGRFAEG 80
Cdd:COG0469    2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  81 KHELAVGDTFTITTEDVPGTKELVSTTHKGLPNDARVGDPILIDDGRVLVRITDVDGPRVVTRVEVAGPVSNNKGLNLPG 160
Cdd:COG0469   82 PVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLPG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 161 VAVSVPAMSDKDEADLRWALRTGADIIALSFVRNASDYDDVRRIMEEEGRVLPVIAKIEKPQAVENLVEIIDAFDGIMVA 240
Cdd:COG0469  162 VGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMVA 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 241 RGDLGVELPLEQVPLVQKRAVELARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLDGADAVMLSGETSVGDYPIE 320
Cdd:COG0469  242 RGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPVE 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 321 AVRTMARIIENTEELGRERI---APLGSTPHTRGGAITRAAAEIGETLGVKYLVTFTQSGDSARRMSRLRSGIPLLAFTP 397
Cdd:COG0469  322 AVETMARIAEEAEKSLDYRRildRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALTP 401

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 398 ETQVRNVLSLSWGVQTYEVSQVESTDAMVKLVDATLRANGLAELGDYVVVVAGAPVGVVGSTNSIVVHKI 467
Cdd:COG0469  402 NERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
PRK06247 PRK06247
pyruvate kinase; Provisional
 2-470 0e+00

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 610.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   2 RRAKIVCTIGPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVRAAAQASGRSVAVLVDLQGPKIRLGRFAEGK 81
Cdd:PRK06247   5 RRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFADGK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  82 HELAVGDTFTITTEDVPGTKELVSTTHKGLPNDARVGDPILIDDGRVLVRITDVDGPRVVTRVEVAGPVSNNKGLNLPGV 161
Cdd:PRK06247  85 VQLANGQTFRLDVDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSLPGT 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 162 AVSVPAMSDKDEADLRWALRTGADIIALSFVRNASDYDDVRRImeeEGRVLPVIAKIEKPQAVENLVEIIDAFDGIMVAR 241
Cdd:PRK06247 165 VLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKI---IGGRVPVMAKIEKPQAIDRLEAIVEASDAIMVAR 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 242 GDLGVELPLEQVPLVQKRAVELARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLDGADAVMLSGETSVGDYPIEA 321
Cdd:PRK06247 242 GDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVEA 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 322 VRTMARIIENTEELGRERI---APLGSTPHTRGGAITRAAAEIGETLGVKYLVTFTQSGDSARRMSRLRSGIPLLAFTPE 398
Cdd:PRK06247 322 VRTMARIIRQVERDPTYPPlihAQRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILALTPN 401

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736618482 399 TQVRNVLSLSWGVQTYEVSQVESTDAMVKLVDATLRANGLAELGDYVVVVAGAPVGVVGSTNSIVVHKIGDE 470
Cdd:PRK06247 402 PETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYIGED 473
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 2-464 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 549.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482    2 RRAKIVCTIGPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVRAAAQASGRSVAVLVDLQGPKIRLGRFAEGK 81
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   82 HELAVGDTFTITTED--VPGTKELVSTTHKGLPNDARVGDPILIDDGRVLVRITDVDGPRVVTRVEVAGPVSNNKGLNLP 159
Cdd:TIGR01064  81 VKLKKGDKVIITTDDikGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  160 GVAVSVPAMSDKDEADLRWALRTGADIIALSFVRNASDYDDVRRIMEEEG-RVLPVIAKIEKPQAVENLVEIIDAFDGIM 238
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNIDEIAEASDGIM 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  239 VARGDLGVELPLEQVPLVQKRAVELARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLDGADAVMLSGETSVGDYP 318
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  319 IEAVRTMARIIENTEELGRER-----IAPLGSTPHTRGGAITRAAAEIGETLGVKYLVTFTQSGDSARRMSRLRSGIPLL 393
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLtnfndRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736618482  394 AFTPETQVRNVLSLSWGVQTYEVSQ-VESTDAMVKLVDATLRANGLAELGDYVVVVAGAPVGVVGSTNSIVV 464
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPFLVDEePSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 1-444 5.13e-169

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 484.90  E-value: 5.13e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   1 MRRAKIVCTIGPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVRAAAQASGRSVAVLVDLQGPKIRLGRFAEG 80
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  81 KH-ELAVGDTFTITTED--VPGTKELVSTTHKGLPNDARVGDPILIDDGRVLVRITDVDGPR-VVTRVEVAGPVSNNKGL 156
Cdd:cd00288   81 KDiSLKAGDKFLVTTDPaaKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 157 NLPGVAVSVPAMSDKDEADLRWALRTGADIIALSFVRNASDYDDVRRIMEEEGRVLPVIAKIEKPQAVENLVEIIDAFDG 236
Cdd:cd00288  161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 237 IMVARGDLGVELPLEQVPLVQKRAVELARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLDGADAVMLSGETSVGD 316
Cdd:cd00288  241 IMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGK 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 317 YPIEAVRTMARIIENTE-----ELGRERIAPLGSTPHTRGGAITRAAAEIGETLGVKYLVTFTQSGDSARRMSRLRSGIP 391
Cdd:cd00288  321 YPVEAVKAMARICLEAEkalshRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAP 400

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 736618482 392 LLAFTPETQVRNVLSLSWGVQTYEVSQV-----ESTDAMVKLVDATLRANGLAELGDY 444
Cdd:cd00288  401 IIAVTRNEQTARQLHLYRGVYPVLFEEPkpgwqEDTDARLKAAVNVAKEKGLLKKGDL 458
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 1-333 3.91e-145

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 419.08  E-value: 3.91e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482    1 MRRAKIVCTIGPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVRAAAQASGRSVAVLVDLQGPKIRLGRFAEG 80
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   81 KH--ELAVGDTFTITTEDV---PGTKELVSTTHKGLPNDARVGDPILIDDGRVLVRITDVDGP-RVVTRVEVAGPVSNNK 154
Cdd:pfam00224  81 KKdiELKAGDEMIVSTDAKykgACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNGGVIGSRK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  155 GLNLPGVAVSVPAMSDKDEADLRWALRTGADIIALSFVRNASDYDDVRRIMEEEGRVLPVIAKIEKPQAVENLVEIIDAF 234
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEAT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  235 DGIMVARGDLGVELPLEQVPLVQKRAVELARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLDGADAVMLSGETSV 314
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320

                         330
                  ....*....|....*....
gi 736618482  315 GDYPIEAVRTMARIIENTE 333
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAE 339
 
Name Accession Description Interval E-value
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 1-467 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 729.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   1 MRRAKIVCTIGPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVRAAAQASGRSVAVLVDLQGPKIRLGRFAEG 80
Cdd:COG0469    2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  81 KHELAVGDTFTITTEDVPGTKELVSTTHKGLPNDARVGDPILIDDGRVLVRITDVDGPRVVTRVEVAGPVSNNKGLNLPG 160
Cdd:COG0469   82 PVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLPG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 161 VAVSVPAMSDKDEADLRWALRTGADIIALSFVRNASDYDDVRRIMEEEGRVLPVIAKIEKPQAVENLVEIIDAFDGIMVA 240
Cdd:COG0469  162 VGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMVA 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 241 RGDLGVELPLEQVPLVQKRAVELARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLDGADAVMLSGETSVGDYPIE 320
Cdd:COG0469  242 RGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPVE 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 321 AVRTMARIIENTEELGRERI---APLGSTPHTRGGAITRAAAEIGETLGVKYLVTFTQSGDSARRMSRLRSGIPLLAFTP 397
Cdd:COG0469  322 AVETMARIAEEAEKSLDYRRildRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALTP 401

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 398 ETQVRNVLSLSWGVQTYEVSQVESTDAMVKLVDATLRANGLAELGDYVVVVAGAPVGVVGSTNSIVVHKI 467
Cdd:COG0469  402 NERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
PRK06247 PRK06247
pyruvate kinase; Provisional
 2-470 0e+00

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 610.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   2 RRAKIVCTIGPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVRAAAQASGRSVAVLVDLQGPKIRLGRFAEGK 81
Cdd:PRK06247   5 RRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFADGK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  82 HELAVGDTFTITTEDVPGTKELVSTTHKGLPNDARVGDPILIDDGRVLVRITDVDGPRVVTRVEVAGPVSNNKGLNLPGV 161
Cdd:PRK06247  85 VQLANGQTFRLDVDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSLPGT 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 162 AVSVPAMSDKDEADLRWALRTGADIIALSFVRNASDYDDVRRImeeEGRVLPVIAKIEKPQAVENLVEIIDAFDGIMVAR 241
Cdd:PRK06247 165 VLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKI---IGGRVPVMAKIEKPQAIDRLEAIVEASDAIMVAR 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 242 GDLGVELPLEQVPLVQKRAVELARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLDGADAVMLSGETSVGDYPIEA 321
Cdd:PRK06247 242 GDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVEA 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 322 VRTMARIIENTEELGRERI---APLGSTPHTRGGAITRAAAEIGETLGVKYLVTFTQSGDSARRMSRLRSGIPLLAFTPE 398
Cdd:PRK06247 322 VRTMARIIRQVERDPTYPPlihAQRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILALTPN 401

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736618482 399 TQVRNVLSLSWGVQTYEVSQVESTDAMVKLVDATLRANGLAELGDYVVVVAGAPVGVVGSTNSIVVHKIGDE 470
Cdd:PRK06247 402 PETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYIGED 473
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 2-464 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 549.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482    2 RRAKIVCTIGPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVRAAAQASGRSVAVLVDLQGPKIRLGRFAEGK 81
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   82 HELAVGDTFTITTED--VPGTKELVSTTHKGLPNDARVGDPILIDDGRVLVRITDVDGPRVVTRVEVAGPVSNNKGLNLP 159
Cdd:TIGR01064  81 VKLKKGDKVIITTDDikGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  160 GVAVSVPAMSDKDEADLRWALRTGADIIALSFVRNASDYDDVRRIMEEEG-RVLPVIAKIEKPQAVENLVEIIDAFDGIM 238
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNIDEIAEASDGIM 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  239 VARGDLGVELPLEQVPLVQKRAVELARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLDGADAVMLSGETSVGDYP 318
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  319 IEAVRTMARIIENTEELGRER-----IAPLGSTPHTRGGAITRAAAEIGETLGVKYLVTFTQSGDSARRMSRLRSGIPLL 393
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLtnfndRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736618482  394 AFTPETQVRNVLSLSWGVQTYEVSQ-VESTDAMVKLVDATLRANGLAELGDYVVVVAGAPVGVVGSTNSIVV 464
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPFLVDEePSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
PRK05826 PRK05826
pyruvate kinase; Provisional
 1-443 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 548.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   1 MRRAKIVCTIGPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVRAAAQASGRSVAVLVDLQGPKIRLGRFAEG 80
Cdd:PRK05826   3 LRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  81 KHELAVGDTFTITTE-DVPGTKELVSTTHKGLPNDARVGDPILIDDGRVLVRITDVDGPRVVTRVEVAGPVSNNKGLNLP 159
Cdd:PRK05826  83 KITLKTGDKFTLDTDqKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINIP 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 160 GVAVSVPAMSDKDEADLRWALRTGADIIALSFVRNASDYDDVRRIMEEEGRV-LPVIAKIEKPQAVENLVEIIDAFDGIM 238
Cdd:PRK05826 163 GGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPhAKIIAKIERAEAVDNIDEIIEASDGIM 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 239 VARGDLGVELPLEQVPLVQKRAVELARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLDGADAVMLSGETSVGDYP 318
Cdd:PRK05826 243 VARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKYP 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 319 IEAVRTMARIIENTEEL--GRERIAPLGSTPHTRGGAITRAAAEIGETL-GVKYLVTFTQSGDSARRMSRLRSGIPLLAF 395
Cdd:PRK05826 323 VEAVEAMARICKGAEKEfsINLSKHRLDRQFDRIDEAIAMSAMYAANHLkGVKAIVALTESGRTARLISRFRPGAPIFAV 402

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 736618482 396 TPETQVRNVLSLSWGVQTYEVSQVESTDAMVKLVDATLRANGLAELGD 443
Cdd:PRK05826 403 TRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGD 450
PRK06354 PRK06354
pyruvate kinase; Provisional
 1-469 5.00e-176

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 506.77  E-value: 5.00e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   1 MRRAKIVCTIGPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVRAAAQASGRSVAVLVDLQGPKIRLGRFAEG 80
Cdd:PRK06354   7 MRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  81 KHELAVGDTFTITTEDVPGTKELVSTTHKGLPNDARVGDPILIDDGRVLVRITDVDGP--RVVTRVEVAGPVSNNKGLNL 158
Cdd:PRK06354  87 PIELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKAdgELHCKVLVGGVLSNKKGVNF 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 159 PGVAVSVPAMSDKDEADLRWALRTGADIIALSFVRNASDYDDVRRIMEEE-GRVLPVIAKIEKPQAVENLVEIIDAFDGI 237
Cdd:PRK06354 167 PGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHnGKHIPIIAKIEKQEAIDNIDAILELCDGL 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 238 MVARGDLGVELPLEQVPLVQKRAVELARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLDGADAVMLSGETSVGDY 317
Cdd:PRK06354 247 MVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDY 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 318 PIEAVRTMARIIENTEE--LGRERIAPLGSTPHTRGGAITRAAAEIGETLGVKYLVTFTQSGDSARRMSRLRSGIPLLAF 395
Cdd:PRK06354 327 PVEAVQTMATIAVRIEKdlPYRDILSKRPEFTTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTPILAV 406

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 736618482 396 TPETQVRNVLSLSWGVQTYEVSQVESTDAMVKLVDATLRANGLAELGDYVVVVAGAPVGVVGSTNSIVVHKIGD 469
Cdd:PRK06354 407 TPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVGA 480
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 1-444 5.13e-169

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 484.90  E-value: 5.13e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   1 MRRAKIVCTIGPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVRAAAQASGRSVAVLVDLQGPKIRLGRFAEG 80
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  81 KH-ELAVGDTFTITTED--VPGTKELVSTTHKGLPNDARVGDPILIDDGRVLVRITDVDGPR-VVTRVEVAGPVSNNKGL 156
Cdd:cd00288   81 KDiSLKAGDKFLVTTDPaaKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 157 NLPGVAVSVPAMSDKDEADLRWALRTGADIIALSFVRNASDYDDVRRIMEEEGRVLPVIAKIEKPQAVENLVEIIDAFDG 236
Cdd:cd00288  161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 237 IMVARGDLGVELPLEQVPLVQKRAVELARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLDGADAVMLSGETSVGD 316
Cdd:cd00288  241 IMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGK 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 317 YPIEAVRTMARIIENTE-----ELGRERIAPLGSTPHTRGGAITRAAAEIGETLGVKYLVTFTQSGDSARRMSRLRSGIP 391
Cdd:cd00288  321 YPVEAVKAMARICLEAEkalshRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAP 400

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 736618482 392 LLAFTPETQVRNVLSLSWGVQTYEVSQV-----ESTDAMVKLVDATLRANGLAELGDY 444
Cdd:cd00288  401 IIAVTRNEQTARQLHLYRGVYPVLFEEPkpgwqEDTDARLKAAVNVAKEKGLLKKGDL 458
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 1-333 3.91e-145

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 419.08  E-value: 3.91e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482    1 MRRAKIVCTIGPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVRAAAQASGRSVAVLVDLQGPKIRLGRFAEG 80
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   81 KH--ELAVGDTFTITTEDV---PGTKELVSTTHKGLPNDARVGDPILIDDGRVLVRITDVDGP-RVVTRVEVAGPVSNNK 154
Cdd:pfam00224  81 KKdiELKAGDEMIVSTDAKykgACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNGGVIGSRK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  155 GLNLPGVAVSVPAMSDKDEADLRWALRTGADIIALSFVRNASDYDDVRRIMEEEGRVLPVIAKIEKPQAVENLVEIIDAF 234
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEAT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  235 DGIMVARGDLGVELPLEQVPLVQKRAVELARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLDGADAVMLSGETSV 314
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320

                         330
                  ....*....|....*....
gi 736618482  315 GDYPIEAVRTMARIIENTE 333
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAE 339
PRK09206 PRK09206
pyruvate kinase PykF;
1-443 2.32e-144

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 421.77  E-value: 2.32e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   1 MRRAKIVCTIGPATESPEQIQALVDAGMDVARLNRSHGDTEVH-QRVyDNVRAAAQASGRSVAVLVDLQGPKIRLGRFAE 79
Cdd:PRK09206   1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHgQRI-KNLRNVMSKTGKKAAILLDTKGPEIRTMKLEG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  80 GKH-ELAVGDTFTITTE-DVPGTKELVSTTHKGLPNDARVGDPILIDDGRVLVRITDVDGPRVVTRVEVAGPVSNNKGLN 157
Cdd:PRK09206  80 GNDvSLKAGQTFTFTTDkSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGVN 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 158 LPGVAVSVPAMSDKDEADLRWALRTGADIIALSFVRNASDYDDVRRIMEEE-GRVLPVIAKIEKPQAVENLVEIIDAFDG 236
Cdd:PRK09206 160 LPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHgGENIQIISKIENQEGLNNFDEILEASDG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 237 IMVARGDLGVELPLEQVPLVQKRAVELARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLDGADAVMLSGETSVGD 316
Cdd:PRK09206 240 IMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGK 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 317 YPIEAVRTMARIIENTEELGRERIAPLGSTPHTR-GGAITRAAAEIGETLGVKYLVTFTQSGDSARRMSRLRSGIPLLAF 395
Cdd:PRK09206 320 YPLEAVSIMATICERTDRVMNSRLESNNDNRKLRiTEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPDATILAL 399

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 736618482 396 TPETQVRNVLSLSWGVQTYEVSQVESTDAMVKLVDATLRANGLAELGD 443
Cdd:PRK09206 400 TTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGD 447
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 2-467 1.33e-118

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 357.15  E-value: 1.33e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   2 RRAKIVCTIGPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVR-AAAQASGRSVAVLVDLQGPKIRLGRFAEG 80
Cdd:PTZ00066  38 KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVReAAKARPNANLGILLDTKGPEIRTGFLKNH 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  81 KH-ELAVGDTFTITTE-DVPGTKELVSTTHKGLPNDARVGDPILIDDGRVLVRITDVDGPRVVTRVEVAGPVSNNKGLNL 158
Cdd:PTZ00066 118 KPiTLKEGQTLKITTDyTFLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMNL 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 159 PGVAVSVPAMSDKDEAD-LRWALRTGADIIALSFVRNASDYDDVRRIMEEEGRVLPVIAKIEKPQAVENLVEIIDAFDGI 237
Cdd:PTZ00066 198 PGVKVELPVIGEKDKNDiLNFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILAESDGI 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 238 MVARGDLGVELPLEQVPLVQKRAVELARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLDGADAVMLSGETSVGDY 317
Cdd:PTZ00066 278 MVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGKF 357

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 318 PIEAVRTMARIIENTE------ELGRERIAPLgSTPHTRGGAITRAAAEIGETLGVKYLVTFTQSGDSARRMSRLRSGIP 391
Cdd:PTZ00066 358 PVEAVNIMAKICFEAEtcidyrVLYHAIHLAV-PTPVSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYRPSCT 436

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736618482 392 LLAFTPETQVRNVLSLSWGVQTYEVSQVESTDAMVKLVDATLRANGLAELGDYVVVVAGAPVGVVGSTNSIVVHKI 467
Cdd:PTZ00066 437 ILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEVAGSSNLMKVVKI 512
PLN02461 PLN02461
Probable pyruvate kinase
 3-393 3.03e-111

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 338.11  E-value: 3.03e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   3 RAKIVCTIGPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVRAAAQASGRSVAVLVDLQGPKIRLGRFAEGKH 82
Cdd:PLN02461  22 KTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLKDGKP 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  83 -ELAVGDTFTITTE-DVPGTKELVSTTHKGLPNDARVGDPILIDDGRV--LVRITDVDGPRVVTRVEVAGPVSNNKGLNL 158
Cdd:PLN02461 102 vQLKQGQEITITTDySIKGDENMIAMSYKKLAVDVKPGSVILCADGTItlTVLSCDVEAGTVRCRCENSAMLGERKNVNL 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 159 PGVAVSVPAMSDKDEAD-LRWALRTGADIIALSFVRNASDYDDVRRIMEEEGRVLPVIAKIEKPQAVENLVEIIDAFDGI 237
Cdd:PLN02461 182 PGVVVDLPTLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNFDDILAESDAF 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 238 MVARGDLGVELPLEQVPLVQKRAVELARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLDGADAVMLSGETSVGDY 317
Cdd:PLN02461 262 MVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETAAGAY 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 318 PIEAVRTMARIIENTE----------ELGRERIAPLGSTPHTRGGAItRAAAEIGETLgvkyLVTFTQSGDSARRMSRLR 387
Cdd:PLN02461 342 PELAVKTMARICREAEasldygalfkEIMRSAPLPMSPLESLASSAV-RTANKVKASL----IVVLTRGGTTARLVAKYR 416


                 ....*.
gi 736618482 388 SGIPLL 393
Cdd:PLN02461 417 PAVPIL 422
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 1-443 5.03e-100

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 309.37  E-value: 5.03e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   1 MRRAKIVCTIGPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVRAAAQASGRSVAVLVDLQGPKIRLGRF--- 77
Cdd:PLN02762  24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDLgga 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  78 AEGKHELAVGDTFTITTEDVPGTKELVSTTHKGLPNDARVGDPILIDDGRVLVRITDVDGPRVVTRVevagpvsNNKGLN 157
Cdd:PLN02762 104 SSAKAEDGEEWTFTVRKFDGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKC-------TDPGLL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 158 LPGVAVS--------------VPAMSDKDEADLRWALRTGADIIALSFVRNASDYDDVRRIMEEE--GRVLPVIAKIEKP 221
Cdd:PLN02762 177 LPRANLTfwrdgslvrernamLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARsrDSDIGVIAKIESL 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 222 QAVENLVEIIDAFDGIMVARGDLGVELPLEQVPLVQKRAVELARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLD 301
Cdd:PLN02762 257 DSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQ 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 302 GADAVMLSGETSVGDYPIEAVRTMARIIENTEELGRE-------RIAPLGSTPHTR-GGAITRAAAEIGETLGVKYLVTF 373
Cdd:PLN02762 337 RADALMLSGESAMGLYPEKALSVLRSVSLRMELWSREekrhealELPQLSSSLSDRiSEEICNSAAKMANNLGVDAIFVY 416

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 374 TQSGDSARRMSRLRSGIPLLAFTPETQVRNVLSLSWGVQTYEVSQVESTDAMVKLVDATLRANGLAELGD 443
Cdd:PLN02762 417 TKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLNKTFSLLKARGMIKSGD 486
PRK06739 PRK06739
pyruvate kinase; Validated
 7-338 5.82e-100

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 303.79  E-value: 5.82e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   7 VCTIGPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVRAAAQasgrSVAVLVDLQGPKIRLGRFAEGKHELAV 86
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDD----SIKILGDVQGPKIRLGEIKGEQITLQA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  87 GDTFTITTEDVPGTKELVSTTHKGLPNDARVGDPILIDDGRVLVRITDVDGPRVVTRVEVAGPVSNNKGLNLPGVAVSVP 166
Cdd:PRK06739  82 GDSFILHTQPVTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVRLP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 167 AMSDKDEADLRWALRTGADIIALSFVRNASDYDDVRRIMEEEGRVLP-VIAKIEKPQAVENLVEIIDAFDGIMVARGDLG 245
Cdd:PRK06739 162 AITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSPnLIAKIETMEAIENFQDICKEADGIMIARGDLG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 246 VELPLEQVPLVQKRAVELARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLDGADAVMLSGETSVGDYPIEAVRTM 325
Cdd:PRK06739 242 VELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVSTL 321

                        330
                 ....*....|...
gi 736618482 326 ARIIENTEELGRE 338
Cdd:PRK06739 322 RLVSEFAEHVKKD 334
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 28-413 1.04e-95

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 296.58  E-value: 1.04e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  28 MDVARLNRSHGDTEVHQRVYDNVRAAAQASGRSVAVLVDLQGPKIRLGRFAEGKHELAVGDTFTITTEDV---PGTKELV 104
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDPAfadKGTKDKF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 105 STTHKGLPNDARVGDPILIDDGRVLVRI-TDVDGPRVVTRVEVAGPVSNNKGLNLPGVAVSVPAMSDKDEADLRWALRTG 183
Cdd:PTZ00300  81 YIDYQNLSKVVRPGGYIYIDDGILILHVqSHEDEQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 184 ADIIALSFVRNASDYDDVRRIMEEEGRVLPVIAKIEKPQAVENLVEIIDAFDGIMVARGDLGVELPLEQVPLVQKRAVEL 263
Cdd:PTZ00300 161 VDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISK 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 264 ARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLDGADAVMLSGETSVGDYPIEAVRTMARIIENTEELGRE----- 338
Cdd:PTZ00300 241 CNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEyvffn 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 736618482 339 RIAPLGSTPHTRGGAITRAAAEIGETLGVKYLVTFTQSGDSARRMSRLRSGIPLLAFTPETQVRNVLSLSWGVQT 413
Cdd:PTZ00300 321 SIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVES 395
PLN02623 PLN02623
pyruvate kinase
 2-411 8.25e-95

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 298.00  E-value: 8.25e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   2 RRAKIVCTIGPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVRA-AAQASGRSVAVLVDLQGPKIRLGRFAEg 80
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEyNAQSKDNVIAIMLDTKGPEVRSGDLPQ- 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  81 KHELAVGDTFTITTEDVPGTKELVSTTHKGLPNDARVGDPILIDDGRVLVRITDVDGPRVVTRVEVAGPVSNNKGLNLPG 160
Cdd:PLN02623 189 PIMLEEGQEFTFTIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNVRG 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 161 VAVSVPAMSDKDEADLRWALRTGADIIALSFVRNASDYDDVRRIMEEEGRVLPVIAKIEKPQAVENLVEIIDAFDGIMVA 240
Cdd:PLN02623 269 KSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIPNLHSIITASDGAMVA 348

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 241 RGDLGVELPLEQVPLVQKRAVELARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLDGADAVMLSGETSVGDYPIE 320
Cdd:PLN02623 349 RGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLK 428

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 321 AVRTMariieNTEELGRERIAPLGSTPHTRGGAITRAAAE--------IGETLGVKYLVtFTQSGDSARRMSRLRSGIPL 392
Cdd:PLN02623 429 AVKVM-----HTVALRTEATLPEGTTPPNLGQAFKNHMSEmfafhatmMANTLGTSIIV-FTRTGFMAILLSHYRPSGTI 502

                        410
                 ....*....|....*....
gi 736618482 393 LAFTPETQVRNVLSLSWGV 411
Cdd:PLN02623 503 FAFTNEKRIQQRLALYQGV 521
PLN02765 PLN02765
pyruvate kinase
 5-395 1.60e-78

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 254.21  E-value: 1.60e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   5 KIVCTIGPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVRAAAQASGRSVAVLVDLQGPKIRLGRFAEGKHEL 84
Cdd:PLN02765  31 KIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPISL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  85 AVGDTFTITT-EDVPGTKELVSTTHKGLPNDARVGDPILI--------DDGRVLVRITDVDGPRVVTRVE----VAGPVS 151
Cdd:PLN02765 111 KAGNTVTLTPdQSKEASSEVLPINFPGLAKAVKPGDTIFVgqylftgsETTSVWLEVDEVKGDDVVCTVKnsatLAGSLF 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 152 NnkgLNLPGVAVSVPAMSDKDEADLR-WALRTGADIIALSFVRNASDYDDVRRIMEEEG-RVLPVIAKIEKPQAVENLVE 229
Cdd:PLN02765 191 T---LHVSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIFAKIENVEGLTHFDE 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 230 IIDAFDGIMVARGDLGVELPLEQVPLVQKRAVELARRAAKPVIVaTQVLESMISAPRPTRAEASDCANAVLDGADAVMLS 309
Cdd:PLN02765 268 ILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGADAILLG 346

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 310 GETSVGDYPIEAVRTMARIIENTE-----ELGRERIAPLGSTPHTRGGAIT----RAAAEIGETLgvkyLVTFTQSGDSA 380
Cdd:PLN02765 347 AETLRGLYPVETISTVGRICAEAEkvfnqDLYFKKTVKYVGEPMSHLESIAssavRAAIKVKASV----IIVFTSSGRAA 422

                        410
                 ....*....|....*
gi 736618482 381 RRMSRLRSGIPLLAF 395
Cdd:PLN02765 423 RLIAKYRPTMPVLSV 437
PRK08187 PRK08187
pyruvate kinase; Validated
 2-328 9.37e-61

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 206.40  E-value: 9.37e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   2 RRAKIVCTI-GPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVRAAAQASGRSVAVLVDLQGPKIRLGRFAE- 79
Cdd:PRK08187 133 RRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGAVAGp 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  80 -GKHELAVGDTFTITTEDVPGTKEL----VSTTHKGLPNDARVGDPILIDDGRVLVRITDVDGPRVVTRVEVAGP----V 150
Cdd:PRK08187 213 lGKTRLYTGDRLALVAQGPPRRIDEehfqVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLEVTHARPkglkL 292

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 151 SNNKGLNLPGVAVSVPAMSDKDEADLRWALRTgADIIALSFVRNASDYDDVRRIMEEEG----RVLPVIAKIEKPQAVEN 226
Cdd:PRK08187 293 KPEKGLNFPDTALDLPALTEKDRADLDFVARH-ADLVGYSFVQSPGDVEALQAALAARRpddwRKLGLVLKIETPRAVAN 371

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 227 LVEIIDAFDG-----IMVARGDLGVELPLEQVPLVQKRAVELARRAAKPVIVATQVLESMISAPRPTRAEASDCANAvlD 301
Cdd:PRK08187 372 LPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMA--A 449

                        330       340
                 ....*....|....*....|....*..
gi 736618482 302 GADAVMLSGetsvGDYPIEAVRTMARI 328
Cdd:PRK08187 450 RAECVMLNK----GPYLVEAVTFLDDL 472
PRK14725 PRK14725
pyruvate kinase; Provisional
 2-334 4.37e-57

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 199.41  E-value: 4.37e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482   2 RRAKIVCTI-GPATESPEQIQALVDAGMDVARLNRSHGDTEVHQRVYDNVRAAAQASGRSVAVLVDLQGPKIRLGRFA-- 78
Cdd:PRK14725 139 RPTRIMVTLpTEAADDPDLVRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEELGRRCRIAMDLAGPKLRTGPIApg 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482     --------------------------------------------------------------------------------
Cdd:PRK14725 219 prviklrptrdalgrvltparlwltasespppspppgpvglpvdpewlarlepgdelrftdargkkrkltvtevddegvl 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  79 -------------------------------EGKHELAVGDTFTITTEDVPGTKEL-------VSTThkgLP---NDARV 117
Cdd:PRK14725 299 aegsqtaylangtllrlgrhdstrvgglppvEQKLRLKVGDRLVLTRDDAPGDPAQgdapparISCT---LPeafRAARV 375

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 118 GDPILIDDGRVLVRITDVDGPRVVTRVEVAGPVSNN----KGLNLPGVAVSVPAMSDKDEADLRWALRTgADIIALSFVR 193
Cdd:PRK14725 376 GERVWFDDGKIGAVVVKVEADEVELRITHARPGGSKlkagKGINLPDSHLPLPALTDKDLEDLAFVAKH-ADIVALSFVR 454

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 194 NASDYDDVRRIMEEEG-RVLPVIAKIEKPQAVENLVEII------DAFdGIMVARGDLGVELPLEQVPLVQKRAVELARR 266
Cdd:PRK14725 455 SPEDVRLLLDALEKLGaDDLGVVLKIETRRAFENLPRILleamrhPRF-GVMIARGDLAVEVGFERLAEVQEEILWLCEA 533

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 736618482 267 AAKPVIVATQVLESMISAPRPTRAEASDCANAVLdgADAVMLSGetsvGDYPIEAVRTMARIIENTEE 334
Cdd:PRK14725 534 AHVPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVMLNK----GPHIVEAVRVLDDILRRMEE 595
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
264-469 9.81e-35

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 132.33  E-value: 9.81e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 264 ARRAAKPVIVATQVLESMISAPRPTRAEASDCANAVLDGADAVMLSGETSVGDYPIEAVRTMARIIENTEE--LGRERIA 341
Cdd:COG3848    2 CNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEdlEYREQRV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482 342 PLGSTPHTR-GGAITRAAAEIGETLGVKYLVTFTQSGDSARRMSRLRSGIPLLAFTPETQVRNVLSLSWGVQTYEVSQVE 420
Cdd:COG3848   82 PRAKESSTTiTDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEESA 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 736618482 421 STDAMVKLVDATLRANGLAELGDYVVVVAGAPVGVVGSTNSIVVHKIGD 469
Cdd:COG3848  162 STDEMFAVAVALALEAGLVKDGDLVVITAGVPVGVSGTTNLLKVHVVGD 210
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 353-465 8.67e-24

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 95.62  E-value: 8.67e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736618482  353 AITRAAAEIGETLGVKYLVTFTQSGDSARRMSRLRSGIPLLAFTPETQVRNVLSLSWGVQTYEVSQVESTDAMVKLVDAT 432
Cdd:pfam02887   2 AIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVKV 81

                          90       100       110
                  ....*....|....*....|....*....|...
gi 736618482  433 LRANGLAELGDYVVVVAGAPVGVVGSTNSIVVH 465
Cdd:pfam02887  82 AKEAGLVKKGDLVVITAGVPFGVSGTTNTLKVI 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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