|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09263 |
PRK09263 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
19-729 |
0e+00 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 236436 [Multi-domain] Cd Length: 711 Bit Score: 1413.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 19 KMTVIKRDGREVPFDEQKINAALIKAEKKIHgslspityEKIQSIAELVIKEIKNRFAN--NVKIYEIQNIVEHILLEKN 96
Cdd:PRK09263 2 MPKVIKRDGRKVPFDSEKIKNAIEKAAKAVE--------VDDEDYCATVAAEIASRVEGrdEVDIEEIQDAVENQLMAGP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 97 EYALAEEYIHYRTKRDFARSKATDINFSIEKLINK-DQSVVNENANKDSNVFNTQRDLTAGIVGKSIGLK-LLPPHIANA 174
Cdd:PRK09263 74 YKALARAYIEYRHDRDIAREKATDLNEEIRGLIEQsNEAVLNENANKDSKVFSTQRDLLAGIVSKHYALRhLLPRDVVNA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 175 HQKGDIHYHDLDYHPYTPMTNCCLIDFKGMLNNGFKIGNAEVESPKSIQTATAQISQIIANVASSQYGGCSADRTDELLA 254
Cdd:PRK09263 154 HEKGDIHYHDLDYSPFFPMFNCCLIDLKGMLTNGFKIGNAEIESPKSIQTATAVTAQIIAQVASSQYGGCTINRIDEVLA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 255 PFAQLNYKKHLIDAKEWIDtPERQEAYAKAKTKKDIFDAMQSLEYEINTLFTSNGQTPFTSLGFGLGKNWFEREIQKAIL 334
Cdd:PRK09263 234 PYAEKSYEKHLKDAEEWVI-EEKAEAYARARTEKEIYDAMQSLEYEINTLHTSNGQTPFVTLGFGLGTSWESRLIQKAIL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 335 QIRINGLGSEKRTAIFPKLIFTLKDGINLKPTDPNYDIKQLALECATKRMYPDILNYDKIVELTGSFKVPMGCRSFLQGW 414
Cdd:PRK09263 313 RNRIAGLGKERKTAIFPKLVFAIKDGLNLKPGDPNYDIKQLALECATKRMYPDILNYDKIVELTGSFKTPMGCRSFLQGW 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 415 KDENGEEVNVGRMNLGVVTLNLPRIALEADGDQEKFWQLLSDRLSIMKDALVYRVERCKEAIPANAPILYMYGAFGKRLS 494
Cdd:PRK09263 393 KDENGEEVHDGRNNLGVVTLNLPRIALEAKGDEDKFWEILDERLELAKKALMTRIERLKGAKPRVAPILYMYGAFGVRLK 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 495 RTDAVDELFKNRRATVSLGYIGLYEVAASFFGGAWENNAEAKDFTLDIVKKLKANADAWGNEYGYHFSVYSTPSESLTDR 574
Cdd:PRK09263 473 ADDDVDELFKNGRATISLGYIGLYETINALYGGSWEVNPEAKAFALAIVKRMKDACDQWKKETGYGFSLYSTPSESLTDR 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 575 FCRLDTEKFGIVENITDKEYYTNSFHYDVRKNPTPFEKLEFEKDYPKYCSGGFIHYCEYPVLQQNPKALEAVWDFAYDKV 654
Cdd:PRK09263 553 FCRLDTEKFGVIPGITDKGYYTNSFHYDVRKKVNPFEKLDFEKPYPPLASGGFIHYCEYPNLQHNLKALEAVWDYSYDRV 632
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 736683222 655 GYLGTNTPIDHCYQCGFEGDFQPTERGFECPECGNHDPKTCDVVKRTCGYLGNPQARPMVHGRHKEISSRVKHMK 729
Cdd:PRK09263 633 GYLGTNTPIDECYECGFTGEFECTEKGFTCPKCGNHDPKTVSVTRRTCGYLGNPDARPFNHGRQEEIKRRVKHMS 707
|
|
| NrdD |
COG1328 |
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; ... |
19-717 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Anaerobic ribonucleoside-triphosphate reductase is part of the Pathway/BioSystem: Thymidylate biosynthesis
Pssm-ID: 440939 [Multi-domain] Cd Length: 671 Bit Score: 916.62 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 19 KMTVIKRDGREVPFDEQKINAALIKAEKKIHGSlsPITYEKIQSIAELVIKEIKNRF-ANNVKIYEIQNIVEHILLEKNE 97
Cdd:COG1328 2 MLKVIKRDGRVVPFDPEKIANAIKKAAKAVGGE--DRDEELAEEIADEVEKELERLGgGGTITVEEIQDIVEKVLMESGH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 98 YALAEEYIHYRTKRDFARSKATDINFSIEKLINKDQSVVNENANKdSNVFNTQRDLTAGIVGKSIGL-KLLPPHIANAHQ 176
Cdd:COG1328 80 PEVAKAYILYREQRTRLREARTTLVDDIELLDEYDDWRVNENANK-SYSFSTQRDLIAGEVSKEYALnKILPPEVADAHR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 177 KGDIHYHDLDYhpYTPMTNCCLIDFKGMLNNGFKIGNAEVESPKSIQTATAQISQIIANVASSQYGGCSADRTDELLAPF 256
Cdd:COG1328 159 NGDIHIHDLDY--LPRMTNCCLWDLRDLLKNGFNGGNGKVEPPKHIQTALAQMAQIIATVQSEQAGGQAFSRFDTYLAPY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 257 AQlnyKKHLidakewidtperqeayaKAKTKKDIFDAMQSLEYEINTLFTSNGQTPFTSLGFGLG----KNWFEREIQKA 332
Cdd:COG1328 237 VR---KDKL-----------------EGKTYKEIKQAMQSLEYNLNTLPSRRGQTPFTSITFGLGtpedFSWEMRMINKA 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 333 ILQIRINGLGsEKRTAIFPKLIFTLKDGINLKPTDPNYDIKQLALECATKRMYPDILNYDKIVEL-TGSFKVPMGCRSFL 411
Cdd:COG1328 297 ILEVRIEGDG-EGRTFIFPKLIFNITEGFNWEPEDPNYDLLQLAFECTAKRGYPYFLNYDNSDELyKGSFKRSMGCRLFL 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 412 QGWkdENGEEVNVGRMNLGVVTLNLPRIALEADGDQEKFWQLLSDRLSIMKDALVYRVERCKEAIPA-NAPILYMYGAFG 490
Cdd:COG1328 376 DGW--ENGEELNRGRGNLGVVTLNLPRIAYEAKGDEEKFFEILDERLDLAKEALEIKRKRLQKLAKAgLAPILYQTGAYL 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 491 KRLSRTDAVDELFKNRRATvsLGYIGLYEVAASFFGGAWENNAEAKDFTLDIVKKLKANADAWGNEYGYHFSVYSTPSES 570
Cdd:COG1328 454 GRLKPDDSIDELFKNGFST--IGYIGLNEMLLNFTGKHHIESEEAKAFALEILKHMRERADEWQEETGYLYSLYATPAES 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 571 LTDRFCRLDTEKFGIVENITDKEYYTNSFHYDVRKNPTPFEKLEFEKDYPKYCSGGFIHYCEYPVLQQNPKALEAVWDFA 650
Cdd:COG1328 532 LTYRFAKLDKKRFGDIIGVTDKPYYTNSFHLPVRKTIDPFEKLDFEDEYQPLYTGGTISYVELGELQPNPEALEAVVRYA 611
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 736683222 651 YD--KVGYLGTNTPIDHCYQCGFEGDFQptergFECPECGNHDpkTCDVVKRTCGYLGNPQarPMVHGR 717
Cdd:COG1328 612 YDnyRIGYLGINPPFDICPKCGYLGGEH-----DECPKCGNED--TVEVIRRTCGYLGNVQ--PWNDGK 671
|
|
| NRDD |
pfam13597 |
Anaerobic ribonucleoside-triphosphate reductase; |
139-727 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase;
Pssm-ID: 463930 [Multi-domain] Cd Length: 554 Bit Score: 711.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 139 NANKDSNVFNTQRDLTAGIVGKSIGLK-LLPPHIANAHQKGDIHYHDLDYHPyTPMTNCCLIDFKGMLNNGFKIGNAEVE 217
Cdd:pfam13597 1 NANKDSYSPSGQRLYIAGEVSKDYALRkLLPPEIADAHEEGDIHIHDLDYYA-LRTPYCCGIDLRDLLENGFVTGNGVSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 218 SPKSIQTATAQISQIIANVASSQYGGCSADRTDELLAPFAQLNYKKHLIDakewidtperqeayakaKTKKDIFDAMQSL 297
Cdd:pfam13597 80 PPKHIETACAQAVNILATVQNEQAGGQAFSSFDTYLAPFVRKDYEKHLKG-----------------LTYKEVKQAMQAF 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 298 EYEINTLFTSNG-QTPFTSLGFGLGKNWFERE----IQKAILQIRINGLGSEKRTAIFPKLIFTLKDGINLKPTDPNYDI 372
Cdd:pfam13597 143 VYNLNTMPSRRGgQTPFTNINLGLDTPKEGRDemdmIIKALLEVMLEGDGNGGTPFTFPIPIYKLKEGFNWDEGDPNYDL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 373 KQLALECATKRMYPDILNYDKIVELTGSFKVPMGCRSFLQGWKDENgeeVNVG-RMNLGVVTLNLPRIALEADGDQEKFW 451
Cdd:pfam13597 223 FELAFECTAKRGYPYFSNFDSDLLPGDGYVASMGCRLRLDLRPNRK---RFGGlRGNIGVVTINLPRIAYEAAGDEDKFF 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 452 QLLSDRLSIMKDALVYRVERCKEAIPAN-APILYMYGAFgkrlsrtdavdelfKNRRATVSLGYIGLYEVAASFFGGAWE 530
Cdd:pfam13597 300 ELLDERLELAKEALLIRREVLKKLLAKGlLPFLMGEGYL--------------RGGNHTLTIGFIGLNEALKALTGKHHG 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 531 NNAEAKDFTLDIVKKLKANADAWGNEYGYHFSVYSTPSESLTDRFCRLDTEKFGIVENITDKEYYTNSFHYDVRKNPTPF 610
Cdd:pfam13597 366 ESEEAKEFALKILKHMREKADEWKEETGLNFSLEATPAESLSYRFAKLDKKRFGEIKGVTDKPYYTNSFHVPVDYTIDAF 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 611 EKLEFEKDYPKYCSGGFIHYCEYPVLQQNPKALEAVWDFAYD-KVGYLGTNTPIDHCYQCGFEGDFqptergFECPECGN 689
Cdd:pfam13597 446 EKLKLEAPFQPLTTGGHISHVELGEAQPNPEALEKLVRIAYDtGIGYFSINPPIDVCPDCGYTGEI------EECPNCGN 519
|
570 580 590
....*....|....*....|....*....|....*...
gi 736683222 690 HDPKtCDVVKRTCGYLGNPQArpMVHGRHKEISSRVKH 727
Cdd:pfam13597 520 HDEK-VEVIRRITGYLRPVSD--WNKGKQAELKDRVKH 554
|
|
| RNR_III |
cd01675 |
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
138-707 |
0e+00 |
|
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in strict or facultative anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). The class III enzyme from phage T4 consists of two subunits, this model covers the larger subunit which contains the active and allosteric sites.
Pssm-ID: 153084 [Multi-domain] Cd Length: 555 Bit Score: 639.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 138 ENANKDSNVFNTQRDLTAGIVGKSIGLKLLPPHIANAHQKGDIHYHDLDYhpYTPMTNCCLIDFKGMLNNGFKIGNAEVE 217
Cdd:cd01675 1 ENANVDSSPGSTMKDLAAGIVKKYYLLKILPKEIARAHLNGDIHIHDLDY--LPLTPYCCGWDLRPLLEKGFTTGNGIIE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 218 SPKSIQTATAQISQIIANVASSQYGGCSADRTDELLAPFAQLNYKKHLIDAkewidtperqeayakakTKKDIFDAMQSL 297
Cdd:cd01675 79 PPKHLSSALGHIVNFLGTVQNEQAGGQAFPEFDTYLAPFVRKDYLKYRLTA-----------------TRKEIKQAMQGF 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 298 EYEINTLFTSNGQTPFTSLGFGLGK-------------------NWFEREIQKAILQIRINGLGsEKRTAIFPKLIFTLK 358
Cdd:cd01675 142 IYNLNTLSRRGGQTPFTNITLGLVCpkdlefegggepvftygdtDKEARMIQKAFLEVRLEGDA-KGRPFTFPIPTFNVT 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 359 DGINLkptDPNYDIKQLALECATKRMYPDILNYDKIVELTGSfKVPMGCRSFLQGWK---DENGEEVNVGRMNLGVVTLN 435
Cdd:cd01675 221 EGFNL---DPNYDLKELAFECAAKRGYPYFLNFDNSDNVPGD-VRAMGCRLFLDKNElkrGGGLEGSGDGTGNIGVVTIN 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 436 LPRIALEADGDQEKFWQLLSDRLSIMKDALVYRVERCKEAIPANAPILYMYGAFGKRlsrtdavdELFKNRRATVSLGYI 515
Cdd:cd01675 297 LPRIAYEARGDEEKFFELLDEYLELAKDALEIRRKRLKEALARGLPPLYQEGLGGGK--------LLFILKRHTLTIGFI 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 516 GLYEVAASFFGGAWENNAEAKDFTLDIVKKLKANADAWGNEYGYHFSVYSTPSESLTDRFCRLDTEKFG-IVENITDKEY 594
Cdd:cd01675 369 GLNEAAEALTGKGIGESEEAREFGIRILEHIRERADEFKEETGLLYSVEATPAESLAYRFAKKDRKKYGdIIPGVTDKPY 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 595 YTNSFHYDVRKNPTPFEKLEFEKDYPKYCSGGFIHYCEYPVLQQNPKALEAVWDFAYDK-VGYLGTNTPIDHCYQCGFEG 673
Cdd:cd01675 449 YTNSFHVPVYEDIDPFEKIDIEAKLHPLTTGGHILHIELGEAKPNPEALEALVKKAAKRgVIYFGINTPIDICNDCGYIG 528
|
570 580 590
....*....|....*....|....*....|....
gi 736683222 674 dfqpTERGFECPECGNHDpktCDVVKRTCGYLGN 707
Cdd:cd01675 529 ----EGEGFKCPKCGSED---VEVISRITGYLGP 555
|
|
| NrdD |
TIGR02487 |
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive ... |
137-727 |
0e+00 |
|
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive (anaerobic, class III) ribonucleotide reductase. The mechanism of the enzyme involves a glycine-centered radical, a C-terminal zinc binding site, and a set of conserved active site cysteines and asparagines. This enzyme requires an activating component, NrdG, a radical-SAM domain containing enzyme (TIGR02491). Together the two form an alpha-2/beta-2 heterodimer. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274159 [Multi-domain] Cd Length: 579 Bit Score: 608.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 137 NENANKDSNVFNTQRDLTAGIVGKSIGLK-LLPPHIANAHQKGDIHYHDLDYhPYTPMTNCCLIDFKGMLNNGFKIGNAE 215
Cdd:TIGR02487 1 NENANMDSPTPSTQRKLIASEVSKDYALLhLLPKDIARAHLNGDIHIHDLDY-ALTLTTNCCLHDLRNLLKYGFRTGNIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 216 VESPKSIQTATAQISQIIANVASSQYGGCSADRTDELLAPFAQLNYKKHLIDAKEWIDTPERQEAYAKAKTKKDIFDAMQ 295
Cdd:TIGR02487 80 SKPPKHIDVALNHIVNILQSLQNEQYGGQSFPEFDTLLAPYIEKTNLKHRKVLQQLQLLLFEATEYAARRTFTDVTQAMQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 296 SLEYEINTLFTSNGQTPFTSLGFGLGKNWFEREIQKAILQIRINGLGsEKRTAIFPKLIFTLKDGINLKPTDPnYDIKQL 375
Cdd:TIGR02487 160 GPEYNPNTLHSAGGQTPFESIGYGTETSKEGRMIAKALLDVRMEGDG-KGEPFIFPKIIFKVREGFNWDEPDP-YDLFEL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 376 ALECATKRMYPDILNYDKIVELTGSFKVPMGCRSFLQGWKDENGEEVNVGRMNLGVVTLNLPRIALEADGDQEKFWQLLS 455
Cdd:TIGR02487 238 AFECAAKRGYPYFLNLDPEDNVKEDVRYPMGCRTFLSPNENGDGEESYIGRGNIGVTSINLPRIAYKSRGDEEEFFEELD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 456 DRLSIMKDALVYRVERCKEAIPANAPILYMYGAFGKRLSRTDAVDELFKNrrATVSLGYIGLYEVAASFFGGAWENNAEA 535
Cdd:TIGR02487 318 EYLEIAKEALEIRREYLKKMLAKDLPPMYSQGGWDGGNLLDESVEEILKS--GTNSIGFIGLNEALVALTGKHLHEEEEA 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 536 KDFTLDIVKKLKANADAWGNEYGYHFSVYSTPSESLTDRFCRLDTEKFGIVENITDKEYYTNSFHYDVRKNPTPFEKLEF 615
Cdd:TIGR02487 396 RELAIRILEFIRDKADEFKKETGLNYSVYATPAESLCGRFAKKDREEFGEIPGVTDKPYYTNSFHVPVYEDVNLGEKIDI 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 616 EKDYPKYCSGGFIHYCEYPVLQQNPKALEAVWDFAYD-KVGYLGTNTPIDHCYQCGFEGDFQpterGFECPECGNHDpkt 694
Cdd:TIGR02487 476 EAPFHPLTNGGHITYIELDEAIPDPEALKDITKKAMKnGIGYFGINPPVDVCEDCGYTGEGL----NDKCPKCGSHD--- 548
|
570 580 590
....*....|....*....|....*....|...
gi 736683222 695 CDVVKRTCGYLGNpqARPMVHGRHKEISSRVKH 727
Cdd:TIGR02487 549 IEVISRITGYLGP--VENWNDGKQAEFKDRKKH 579
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09263 |
PRK09263 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
19-729 |
0e+00 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 236436 [Multi-domain] Cd Length: 711 Bit Score: 1413.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 19 KMTVIKRDGREVPFDEQKINAALIKAEKKIHgslspityEKIQSIAELVIKEIKNRFAN--NVKIYEIQNIVEHILLEKN 96
Cdd:PRK09263 2 MPKVIKRDGRKVPFDSEKIKNAIEKAAKAVE--------VDDEDYCATVAAEIASRVEGrdEVDIEEIQDAVENQLMAGP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 97 EYALAEEYIHYRTKRDFARSKATDINFSIEKLINK-DQSVVNENANKDSNVFNTQRDLTAGIVGKSIGLK-LLPPHIANA 174
Cdd:PRK09263 74 YKALARAYIEYRHDRDIAREKATDLNEEIRGLIEQsNEAVLNENANKDSKVFSTQRDLLAGIVSKHYALRhLLPRDVVNA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 175 HQKGDIHYHDLDYHPYTPMTNCCLIDFKGMLNNGFKIGNAEVESPKSIQTATAQISQIIANVASSQYGGCSADRTDELLA 254
Cdd:PRK09263 154 HEKGDIHYHDLDYSPFFPMFNCCLIDLKGMLTNGFKIGNAEIESPKSIQTATAVTAQIIAQVASSQYGGCTINRIDEVLA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 255 PFAQLNYKKHLIDAKEWIDtPERQEAYAKAKTKKDIFDAMQSLEYEINTLFTSNGQTPFTSLGFGLGKNWFEREIQKAIL 334
Cdd:PRK09263 234 PYAEKSYEKHLKDAEEWVI-EEKAEAYARARTEKEIYDAMQSLEYEINTLHTSNGQTPFVTLGFGLGTSWESRLIQKAIL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 335 QIRINGLGSEKRTAIFPKLIFTLKDGINLKPTDPNYDIKQLALECATKRMYPDILNYDKIVELTGSFKVPMGCRSFLQGW 414
Cdd:PRK09263 313 RNRIAGLGKERKTAIFPKLVFAIKDGLNLKPGDPNYDIKQLALECATKRMYPDILNYDKIVELTGSFKTPMGCRSFLQGW 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 415 KDENGEEVNVGRMNLGVVTLNLPRIALEADGDQEKFWQLLSDRLSIMKDALVYRVERCKEAIPANAPILYMYGAFGKRLS 494
Cdd:PRK09263 393 KDENGEEVHDGRNNLGVVTLNLPRIALEAKGDEDKFWEILDERLELAKKALMTRIERLKGAKPRVAPILYMYGAFGVRLK 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 495 RTDAVDELFKNRRATVSLGYIGLYEVAASFFGGAWENNAEAKDFTLDIVKKLKANADAWGNEYGYHFSVYSTPSESLTDR 574
Cdd:PRK09263 473 ADDDVDELFKNGRATISLGYIGLYETINALYGGSWEVNPEAKAFALAIVKRMKDACDQWKKETGYGFSLYSTPSESLTDR 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 575 FCRLDTEKFGIVENITDKEYYTNSFHYDVRKNPTPFEKLEFEKDYPKYCSGGFIHYCEYPVLQQNPKALEAVWDFAYDKV 654
Cdd:PRK09263 553 FCRLDTEKFGVIPGITDKGYYTNSFHYDVRKKVNPFEKLDFEKPYPPLASGGFIHYCEYPNLQHNLKALEAVWDYSYDRV 632
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 736683222 655 GYLGTNTPIDHCYQCGFEGDFQPTERGFECPECGNHDPKTCDVVKRTCGYLGNPQARPMVHGRHKEISSRVKHMK 729
Cdd:PRK09263 633 GYLGTNTPIDECYECGFTGEFECTEKGFTCPKCGNHDPKTVSVTRRTCGYLGNPDARPFNHGRQEEIKRRVKHMS 707
|
|
| NrdD |
COG1328 |
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; ... |
19-717 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Anaerobic ribonucleoside-triphosphate reductase is part of the Pathway/BioSystem: Thymidylate biosynthesis
Pssm-ID: 440939 [Multi-domain] Cd Length: 671 Bit Score: 916.62 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 19 KMTVIKRDGREVPFDEQKINAALIKAEKKIHGSlsPITYEKIQSIAELVIKEIKNRF-ANNVKIYEIQNIVEHILLEKNE 97
Cdd:COG1328 2 MLKVIKRDGRVVPFDPEKIANAIKKAAKAVGGE--DRDEELAEEIADEVEKELERLGgGGTITVEEIQDIVEKVLMESGH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 98 YALAEEYIHYRTKRDFARSKATDINFSIEKLINKDQSVVNENANKdSNVFNTQRDLTAGIVGKSIGL-KLLPPHIANAHQ 176
Cdd:COG1328 80 PEVAKAYILYREQRTRLREARTTLVDDIELLDEYDDWRVNENANK-SYSFSTQRDLIAGEVSKEYALnKILPPEVADAHR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 177 KGDIHYHDLDYhpYTPMTNCCLIDFKGMLNNGFKIGNAEVESPKSIQTATAQISQIIANVASSQYGGCSADRTDELLAPF 256
Cdd:COG1328 159 NGDIHIHDLDY--LPRMTNCCLWDLRDLLKNGFNGGNGKVEPPKHIQTALAQMAQIIATVQSEQAGGQAFSRFDTYLAPY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 257 AQlnyKKHLidakewidtperqeayaKAKTKKDIFDAMQSLEYEINTLFTSNGQTPFTSLGFGLG----KNWFEREIQKA 332
Cdd:COG1328 237 VR---KDKL-----------------EGKTYKEIKQAMQSLEYNLNTLPSRRGQTPFTSITFGLGtpedFSWEMRMINKA 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 333 ILQIRINGLGsEKRTAIFPKLIFTLKDGINLKPTDPNYDIKQLALECATKRMYPDILNYDKIVEL-TGSFKVPMGCRSFL 411
Cdd:COG1328 297 ILEVRIEGDG-EGRTFIFPKLIFNITEGFNWEPEDPNYDLLQLAFECTAKRGYPYFLNYDNSDELyKGSFKRSMGCRLFL 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 412 QGWkdENGEEVNVGRMNLGVVTLNLPRIALEADGDQEKFWQLLSDRLSIMKDALVYRVERCKEAIPA-NAPILYMYGAFG 490
Cdd:COG1328 376 DGW--ENGEELNRGRGNLGVVTLNLPRIAYEAKGDEEKFFEILDERLDLAKEALEIKRKRLQKLAKAgLAPILYQTGAYL 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 491 KRLSRTDAVDELFKNRRATvsLGYIGLYEVAASFFGGAWENNAEAKDFTLDIVKKLKANADAWGNEYGYHFSVYSTPSES 570
Cdd:COG1328 454 GRLKPDDSIDELFKNGFST--IGYIGLNEMLLNFTGKHHIESEEAKAFALEILKHMRERADEWQEETGYLYSLYATPAES 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 571 LTDRFCRLDTEKFGIVENITDKEYYTNSFHYDVRKNPTPFEKLEFEKDYPKYCSGGFIHYCEYPVLQQNPKALEAVWDFA 650
Cdd:COG1328 532 LTYRFAKLDKKRFGDIIGVTDKPYYTNSFHLPVRKTIDPFEKLDFEDEYQPLYTGGTISYVELGELQPNPEALEAVVRYA 611
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 736683222 651 YD--KVGYLGTNTPIDHCYQCGFEGDFQptergFECPECGNHDpkTCDVVKRTCGYLGNPQarPMVHGR 717
Cdd:COG1328 612 YDnyRIGYLGINPPFDICPKCGYLGGEH-----DECPKCGNED--TVEVIRRTCGYLGNVQ--PWNDGK 671
|
|
| NRDD |
pfam13597 |
Anaerobic ribonucleoside-triphosphate reductase; |
139-727 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase;
Pssm-ID: 463930 [Multi-domain] Cd Length: 554 Bit Score: 711.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 139 NANKDSNVFNTQRDLTAGIVGKSIGLK-LLPPHIANAHQKGDIHYHDLDYHPyTPMTNCCLIDFKGMLNNGFKIGNAEVE 217
Cdd:pfam13597 1 NANKDSYSPSGQRLYIAGEVSKDYALRkLLPPEIADAHEEGDIHIHDLDYYA-LRTPYCCGIDLRDLLENGFVTGNGVSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 218 SPKSIQTATAQISQIIANVASSQYGGCSADRTDELLAPFAQLNYKKHLIDakewidtperqeayakaKTKKDIFDAMQSL 297
Cdd:pfam13597 80 PPKHIETACAQAVNILATVQNEQAGGQAFSSFDTYLAPFVRKDYEKHLKG-----------------LTYKEVKQAMQAF 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 298 EYEINTLFTSNG-QTPFTSLGFGLGKNWFERE----IQKAILQIRINGLGSEKRTAIFPKLIFTLKDGINLKPTDPNYDI 372
Cdd:pfam13597 143 VYNLNTMPSRRGgQTPFTNINLGLDTPKEGRDemdmIIKALLEVMLEGDGNGGTPFTFPIPIYKLKEGFNWDEGDPNYDL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 373 KQLALECATKRMYPDILNYDKIVELTGSFKVPMGCRSFLQGWKDENgeeVNVG-RMNLGVVTLNLPRIALEADGDQEKFW 451
Cdd:pfam13597 223 FELAFECTAKRGYPYFSNFDSDLLPGDGYVASMGCRLRLDLRPNRK---RFGGlRGNIGVVTINLPRIAYEAAGDEDKFF 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 452 QLLSDRLSIMKDALVYRVERCKEAIPAN-APILYMYGAFgkrlsrtdavdelfKNRRATVSLGYIGLYEVAASFFGGAWE 530
Cdd:pfam13597 300 ELLDERLELAKEALLIRREVLKKLLAKGlLPFLMGEGYL--------------RGGNHTLTIGFIGLNEALKALTGKHHG 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 531 NNAEAKDFTLDIVKKLKANADAWGNEYGYHFSVYSTPSESLTDRFCRLDTEKFGIVENITDKEYYTNSFHYDVRKNPTPF 610
Cdd:pfam13597 366 ESEEAKEFALKILKHMREKADEWKEETGLNFSLEATPAESLSYRFAKLDKKRFGEIKGVTDKPYYTNSFHVPVDYTIDAF 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 611 EKLEFEKDYPKYCSGGFIHYCEYPVLQQNPKALEAVWDFAYD-KVGYLGTNTPIDHCYQCGFEGDFqptergFECPECGN 689
Cdd:pfam13597 446 EKLKLEAPFQPLTTGGHISHVELGEAQPNPEALEKLVRIAYDtGIGYFSINPPIDVCPDCGYTGEI------EECPNCGN 519
|
570 580 590
....*....|....*....|....*....|....*...
gi 736683222 690 HDPKtCDVVKRTCGYLGNPQArpMVHGRHKEISSRVKH 727
Cdd:pfam13597 520 HDEK-VEVIRRITGYLRPVSD--WNKGKQAELKDRVKH 554
|
|
| RNR_III |
cd01675 |
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
138-707 |
0e+00 |
|
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in strict or facultative anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). The class III enzyme from phage T4 consists of two subunits, this model covers the larger subunit which contains the active and allosteric sites.
Pssm-ID: 153084 [Multi-domain] Cd Length: 555 Bit Score: 639.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 138 ENANKDSNVFNTQRDLTAGIVGKSIGLKLLPPHIANAHQKGDIHYHDLDYhpYTPMTNCCLIDFKGMLNNGFKIGNAEVE 217
Cdd:cd01675 1 ENANVDSSPGSTMKDLAAGIVKKYYLLKILPKEIARAHLNGDIHIHDLDY--LPLTPYCCGWDLRPLLEKGFTTGNGIIE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 218 SPKSIQTATAQISQIIANVASSQYGGCSADRTDELLAPFAQLNYKKHLIDAkewidtperqeayakakTKKDIFDAMQSL 297
Cdd:cd01675 79 PPKHLSSALGHIVNFLGTVQNEQAGGQAFPEFDTYLAPFVRKDYLKYRLTA-----------------TRKEIKQAMQGF 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 298 EYEINTLFTSNGQTPFTSLGFGLGK-------------------NWFEREIQKAILQIRINGLGsEKRTAIFPKLIFTLK 358
Cdd:cd01675 142 IYNLNTLSRRGGQTPFTNITLGLVCpkdlefegggepvftygdtDKEARMIQKAFLEVRLEGDA-KGRPFTFPIPTFNVT 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 359 DGINLkptDPNYDIKQLALECATKRMYPDILNYDKIVELTGSfKVPMGCRSFLQGWK---DENGEEVNVGRMNLGVVTLN 435
Cdd:cd01675 221 EGFNL---DPNYDLKELAFECAAKRGYPYFLNFDNSDNVPGD-VRAMGCRLFLDKNElkrGGGLEGSGDGTGNIGVVTIN 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 436 LPRIALEADGDQEKFWQLLSDRLSIMKDALVYRVERCKEAIPANAPILYMYGAFGKRlsrtdavdELFKNRRATVSLGYI 515
Cdd:cd01675 297 LPRIAYEARGDEEKFFELLDEYLELAKDALEIRRKRLKEALARGLPPLYQEGLGGGK--------LLFILKRHTLTIGFI 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 516 GLYEVAASFFGGAWENNAEAKDFTLDIVKKLKANADAWGNEYGYHFSVYSTPSESLTDRFCRLDTEKFG-IVENITDKEY 594
Cdd:cd01675 369 GLNEAAEALTGKGIGESEEAREFGIRILEHIRERADEFKEETGLLYSVEATPAESLAYRFAKKDRKKYGdIIPGVTDKPY 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 595 YTNSFHYDVRKNPTPFEKLEFEKDYPKYCSGGFIHYCEYPVLQQNPKALEAVWDFAYDK-VGYLGTNTPIDHCYQCGFEG 673
Cdd:cd01675 449 YTNSFHVPVYEDIDPFEKIDIEAKLHPLTTGGHILHIELGEAKPNPEALEALVKKAAKRgVIYFGINTPIDICNDCGYIG 528
|
570 580 590
....*....|....*....|....*....|....
gi 736683222 674 dfqpTERGFECPECGNHDpktCDVVKRTCGYLGN 707
Cdd:cd01675 529 ----EGEGFKCPKCGSED---VEVISRITGYLGP 555
|
|
| NrdD |
TIGR02487 |
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive ... |
137-727 |
0e+00 |
|
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive (anaerobic, class III) ribonucleotide reductase. The mechanism of the enzyme involves a glycine-centered radical, a C-terminal zinc binding site, and a set of conserved active site cysteines and asparagines. This enzyme requires an activating component, NrdG, a radical-SAM domain containing enzyme (TIGR02491). Together the two form an alpha-2/beta-2 heterodimer. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274159 [Multi-domain] Cd Length: 579 Bit Score: 608.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 137 NENANKDSNVFNTQRDLTAGIVGKSIGLK-LLPPHIANAHQKGDIHYHDLDYhPYTPMTNCCLIDFKGMLNNGFKIGNAE 215
Cdd:TIGR02487 1 NENANMDSPTPSTQRKLIASEVSKDYALLhLLPKDIARAHLNGDIHIHDLDY-ALTLTTNCCLHDLRNLLKYGFRTGNIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 216 VESPKSIQTATAQISQIIANVASSQYGGCSADRTDELLAPFAQLNYKKHLIDAKEWIDTPERQEAYAKAKTKKDIFDAMQ 295
Cdd:TIGR02487 80 SKPPKHIDVALNHIVNILQSLQNEQYGGQSFPEFDTLLAPYIEKTNLKHRKVLQQLQLLLFEATEYAARRTFTDVTQAMQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 296 SLEYEINTLFTSNGQTPFTSLGFGLGKNWFEREIQKAILQIRINGLGsEKRTAIFPKLIFTLKDGINLKPTDPnYDIKQL 375
Cdd:TIGR02487 160 GPEYNPNTLHSAGGQTPFESIGYGTETSKEGRMIAKALLDVRMEGDG-KGEPFIFPKIIFKVREGFNWDEPDP-YDLFEL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 376 ALECATKRMYPDILNYDKIVELTGSFKVPMGCRSFLQGWKDENGEEVNVGRMNLGVVTLNLPRIALEADGDQEKFWQLLS 455
Cdd:TIGR02487 238 AFECAAKRGYPYFLNLDPEDNVKEDVRYPMGCRTFLSPNENGDGEESYIGRGNIGVTSINLPRIAYKSRGDEEEFFEELD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 456 DRLSIMKDALVYRVERCKEAIPANAPILYMYGAFGKRLSRTDAVDELFKNrrATVSLGYIGLYEVAASFFGGAWENNAEA 535
Cdd:TIGR02487 318 EYLEIAKEALEIRREYLKKMLAKDLPPMYSQGGWDGGNLLDESVEEILKS--GTNSIGFIGLNEALVALTGKHLHEEEEA 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 536 KDFTLDIVKKLKANADAWGNEYGYHFSVYSTPSESLTDRFCRLDTEKFGIVENITDKEYYTNSFHYDVRKNPTPFEKLEF 615
Cdd:TIGR02487 396 RELAIRILEFIRDKADEFKKETGLNYSVYATPAESLCGRFAKKDREEFGEIPGVTDKPYYTNSFHVPVYEDVNLGEKIDI 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 616 EKDYPKYCSGGFIHYCEYPVLQQNPKALEAVWDFAYD-KVGYLGTNTPIDHCYQCGFEGDFQpterGFECPECGNHDpkt 694
Cdd:TIGR02487 476 EAPFHPLTNGGHITYIELDEAIPDPEALKDITKKAMKnGIGYFGINPPVDVCEDCGYTGEGL----NDKCPKCGSHD--- 548
|
570 580 590
....*....|....*....|....*....|...
gi 736683222 695 CDVVKRTCGYLGNpqARPMVHGRHKEISSRVKH 727
Cdd:TIGR02487 549 IEVISRITGYLGP--VENWNDGKQAEFKDRKKH 579
|
|
| PRK07111 |
PRK07111 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
21-728 |
3.06e-152 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 235937 [Multi-domain] Cd Length: 735 Bit Score: 460.19 E-value: 3.06e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 21 TVIKRDGREVPFDEQKINAALIKAEKKIHGSLSpitYEKIQSIAELVIKEIKNRFANNVKIYEIQNIVEHILLEKNEYAL 100
Cdd:PRK07111 4 YIVKRDGREVPFDEEKITNAIFKAAEAVGGELD---ESEAIELTQKVIKYLEEKYKEEVTVEDIQDLVEKVLIENGHAET 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 101 AEEYIHYRTKRDFARSKATDINFSIEKLINKdqsVVNENANKDSNVFNTQRDLTAGIVGKSIGLK-LLPPHIANAHQKGD 179
Cdd:PRK07111 81 AKAYILYRAERTRIREIKSDLMKAIEEIGND---TDRENANVSGNTPSGKMLRIASESNKDYYNLyLLPKELAKAHENGD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 180 IHYHDLDYHPYTpmTNCCLIDFKGMLNNGFKIGNAEVESPKSIQTATAQISQIIANVASSQYGGCSADRTDELLAPFAQL 259
Cdd:PRK07111 158 IHIHDLDFYNLT--TTCLQIDLKKLLERGFNTGHGYIREPKRIESAAALACIILQSNQNDMHGGQSIPNFDNDMAPFVEK 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 260 NYKKHLIDA----------KEWIDTPERQEAY------------------------AKAKTKKDIFDAMQSLEYEINTLF 305
Cdd:PRK07111 236 TFRRHRKEIlekllelgvgEEVDEKESLNEEEellllllaldfniakkaqekadelAEKETRKRTYQAMEGFIHNLNTMH 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 306 TSNG-QTPFTSLGFGLGKNWFEREIQKAILQIRINGLGSEKrTAIFPKLIFTLKDGINLKPTDPNYDIKQLALECATKRM 384
Cdd:PRK07111 316 SRAGaQVPFSSINYGTDTSPEGRMVCENLLLATEKGLGKGE-TPIFPIQIFRVKEGVNYNEEDPNYDLFKLACRVAAKRL 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 385 YPDILN---------YDKiveltGSFKVP---MGCRSFLQGwkDENGEEVNVGRMNLGVVTLNLPRIALEADGDQEKFWQ 452
Cdd:PRK07111 395 FPNFSFldapfnkeyYDK-----GRPPTEvatMGCRTRVMS--NVNGEEGTKGRGNLSFTTINLPRLAIEAKKDIDKFFE 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 453 LLSDRLSIMKDALVYRVERCKEAIPANAPILYMYGAF--GKRLSRTDAVDELFKNrrATVSLGYIGLYEVAASFFGGAWE 530
Cdd:PRK07111 468 LLDERLELAIEQLLHRYEVQKTLKVKDFPFLMGQGLWkgSENLGPDDSIEPVLKQ--GTLGIGFIGLAETLVALTGKHHG 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 531 NNAEAKDFTLDIVKKLKANADAWGNEYGYHFSVYSTPSESLTDRFCRLDTEKFGIVENITDKEYYTNSFHYDVRKNPTPF 610
Cdd:PRK07111 546 ESEEAQELGLKIVSHMRDFCDEYKEEYKLNYSLLATPAEGLSGRFIKMDRKKFGEIKGVTDKEYYTNSFHVPVYYPISIF 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 611 EKLEFEKDYPKYCSGGFIHYCE---YPvlQQNPKALEAVwDFAYDK--VGYLGTNTPIDHCYQCGFEGDFqpterGFECP 685
Cdd:PRK07111 626 EKIEIEAPYHKLTNGGHISYVEldgDP--SKNVEAFEII-VKAMKNtnIGYGSINHPVDRCPVCGYLGVI-----EDKCP 697
|
730 740 750 760
....*....|....*....|....*....|....*....|....*...
gi 736683222 686 ECGNHDpktCDVVKRTCGYLG-----NPqarpmvhGRHKEISSRVKHM 728
Cdd:PRK07111 698 KCGSTN---IQRIRRITGYLGtldrfNS-------AKKAERRDRVKHG 735
|
|
| PRK14704 |
PRK14704 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
131-727 |
6.76e-105 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 184798 [Multi-domain] Cd Length: 618 Bit Score: 333.69 E-value: 6.76e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 131 KDQSVVNENANKDSNVFNTQRDLTAGIVGKSIGLK-LLPPHIANAHQKGDIHYHDLDYHPyTPMTNCCLIDFKGMLNNGF 209
Cdd:PRK14704 22 NEQDLMQENANVDGRSPMGVMGTFASESAKYYAVEnLLSDQVKKAINENILYPHDLDFYA-TGTTTCSQIPLAQMLANGF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 210 KIGNAEVESPKSIQTATAQISQIIANVASSQYGGCSADRTDELLAPFAQLNYKKHLIDAKEWIDTPERQEAYAKAKTKKD 289
Cdd:PRK14704 101 HTGHGHMRQPQDIKSALALSSIIFQANQNMQHGGQSFALFDVDLAPYVRKTVERHKKRLQSYPLTKEQIEEFAWKETEND 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 290 IFDAMQSLEYEINTLFT-SNGQTPFTSLGFGLGKNWFEREIQKAILQIRINGLGSEKrTAIFPKLIFTLKDGINLKPTDP 368
Cdd:PRK14704 181 TYQACEAFIHNSNSMHSrGGGQVPFISINYGTDTSKEGRLLIKQLLKATQAGLGKGE-TPIFPIQIFKMKKGVNFEESDP 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 369 NYDIKQLALECATKRMYPDILNYDKIVELTGSFKVP------MGCRSFLQGwkDENGEEVNVGRMNLGVVTLNLPRIALe 442
Cdd:PRK14704 260 NYDLFELALETTAERLFPNFSFLDAPFNAVHYDGRPesevcyMGCRTRVMS--NIHGEETAIGRGNLSFTSINLVKLAL- 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 443 ADGDQEKFWQLLSDRLSIMKDALVYRVE-RCKEAiPANAPILYMYGAF--GKRLSRTDAVDELFKnrRATVSLGYIGLYE 519
Cdd:PRK14704 337 ISGSKEAFFEALNYYLDLGIKQLLERFEyQCTKR-ARDFRFLYSQGVWrgGEKLQPEDSVASILK--QGTLSLGFIGLAE 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 520 VAASFFGGAWENNAEAKDFTLDIVKKLKANADAWGNEYGYHFSVYSTPSESLTDRFCRLDTEKFGIVENITDKEYYTNSF 599
Cdd:PRK14704 414 CLVALTGKHHGEDEESWKLGYEIISFMRDRMDKATEEHELNFSVIATPAEGLSGKFVKKDREEFGVISGITNHNYYTNSF 493
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 600 HYDVRKNPTPFEKLEFEKDYPKYCSGGFIHYCEYP-VLQQNPKALEA-VWDFAYDKVGYLGTNTPIDHCYQCGFEGdfqP 677
Cdd:PRK14704 494 HIPVYYNIQAINKIRLEGPFHALCNGGHITYIELDgAAMHNKKALKQiVQAMAEHGVGYGSINHPVDRCKCCSYHG---V 570
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|
gi 736683222 678 TERgfECPECGNHDPKTCDVVKRTCGYLGNPQARPMVHGRHKEiSSRVKH 727
Cdd:PRK14704 571 IGN--ECPSCGNEDEANIERIRRITGYLVGDMSKWNSAKRSEE-MDRVKH 617
|
|
| PRK08270 |
PRK08270 |
ribonucleoside triphosphate reductase; |
20-700 |
1.24e-44 |
|
ribonucleoside triphosphate reductase;
Pssm-ID: 236212 [Multi-domain] Cd Length: 656 Bit Score: 170.41 E-value: 1.24e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 20 MTVIKRDGREVPFDEQKINAALIKAEKKIHGSlspiTYEKIQSIAELVIKEIKNRFANNVKiyEIQNIVEHILLEKNEYA 99
Cdd:PRK08270 3 TKIIKRDGRIVPFDAEKITEAIAKAFKATGEF----DPSEAERLALRVIEKLEDEDIPSVE--EIQDIVEKVLIEAGYFK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 100 LAEEYIHYRTKRDFARSKAT---DINFSIEKLINKDQSVVNENANKD-SN---VFNtqrdlTAGIVGKSIGL-KLLPPHI 171
Cdd:PRK08270 77 TAKAYILYREQHARLRNDKKtllDVEDTVDEYLDREDWRVNENSNMGySLqglILN-----ISGKVTANYWLnKVYPPEI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 172 ANAHQKGDIHYHDLDY-HPYtpmtnCCLIDFKGMLNNGFKIGNAEVES--PKSIQTATAQI-------------SQIIAN 235
Cdd:PRK08270 152 GEAHRNGDLHIHDLDMlSGY-----CAGWSLRDLLLEGFNGVPGKVESkpPKHFRSALGQIvnflgtlqnewagAQAFSS 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 236 VassqyggcsadrtDELLAPFAqlnYKKHLidakewidtperqeayakakTKKDIFDAMQSLEYEINTLFTSNGQTPFTS 315
Cdd:PRK08270 227 F-------------DTYLAPFV---RKDGL--------------------SYKEVKQAIQEFVFNLNVPSRWGFQTPFTN 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 316 LGFGL--------------GKNW------FERE---IQKAILQIRINGlgsEKRTAIFPKLIftlkdginlkptdPNYDI 372
Cdd:PRK08270 271 LTFDLtvpedlkdqpviigGEEMdftygdFQKEmdmINRAFIEVMLEG---DANGRVFTFPI-------------PTYNI 334
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 373 kqlalecaTKRMYPDILNYDKIVELTGSFKVP-----------------MGCRsfLQ--------------GWKDENGee 421
Cdd:PRK08270 335 --------TKDFDWDSENADLLFEMTAKYGLPyfqnfinsdlkpedvrsMCCR--LQldlrelrkrggglfGSAELTG-- 402
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 422 vnvgrmNLGVVTLNLPRIALEADgDQEKFWQLLSDRLSIMKDALVYRVERCKEAIPANapiLYMYgafGKRLSRTdavde 501
Cdd:PRK08270 403 ------SIGVVTINLPRLGYLSK-DEEEFFARLDELMDLAKDSLEIKRKVIERLTDKG---LYPY---TKRYLGT----- 464
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 502 lFKNRRATvsLGYIGLYEVAASFFGgawEN--NAEAKDFTLDIVKKLKANADAWGNEYGYHFSVYSTPSESLTDRFCRLD 579
Cdd:PRK08270 465 -LRNHFST--IGLNGMNEACLNFLG---KDitTEEGRAFALRVLDHMRERLVEFQEETGNLYNLEATPAEGTTYRLAKED 538
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 580 TEKFG--IVENITDKEYYTNSFHYDVRKNPTPFEKLEFEKDY-PKYCSGGFIH-YceypvLQQNPKALEAVWDFA----- 650
Cdd:PRK08270 539 KKRYPdiITAGTDEEPYYTNSTQLPVGYTDDPFEALELQDELqTKYTGGTVFHlY-----LGEAISDAEACKKLVkkale 613
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*.
gi 736683222 651 -YdKVGYLgTNTPI-----DHCYQCGfegdfqpteRGFECPECGnhdpKTCDVVKR 700
Cdd:PRK08270 614 nY-RLPYI-TITPTfsicpKHGYLSG---------EHEFCPKCG----EETEVYSR 654
|
|
| RNR_PFL |
cd00576 |
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ... |
168-661 |
1.61e-38 |
|
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain] Cd Length: 401 Bit Score: 147.68 E-value: 1.61e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 168 PPHIANAHQKGDIHYHDldyhPYTPMTNCCLIDFKGMLNNGFKIGNaevESPKSIQTATAQISQIIANVASSQ-YGGCSA 246
Cdd:cd00576 1 AERIYEAVKSGVITVGR----PDLPFTGCVLVDYGDSLDPGIKGVN---ETAKSINEAIQKTYQIIALAASNQnGGGVSF 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 247 DRTDELLAPfaqlnykkhlidakewidTPERQEAyAKAKTKKDIFDAMQSLEYEINTLFTSNGQTPFTSLGFGLGKNWFE 326
Cdd:cd00576 74 ARASSILSP------------------YGSRDYA-KGSGTETDAVEAADAFNLALKEVGQGNGRTGAATGFIGGVHKGKG 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 327 REIQKAILQIRINGLGsEKRTAIFPKL---IFTLKDGINlkptDPNYDIKQLALECATKRMYPDILNydkiveltgsfkv 403
Cdd:cd00576 135 DKISQEFLNLALANGG-EGIPLNFPNLsvrVSSDKPGIL----VKAVELKQLIAEEARKTGSPGIFN------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 404 pmgcrsflqgwkdengeevnvGRMNLGvVTLNLPRIALEADGDQEKfwqllsdrlsIMKDALVYRVERCKEAipanAPIL 483
Cdd:cd00576 197 ---------------------DELCNL-VSLNLARIMEKAINGSMD----------VVLEELEELAFLAVRA----LDCV 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 484 YMYGAFGKrlsrtdAVDELFKNRRATVSLGYIGLYEVAASfFGGAWENNAEAKDFTLDIVKKLKANADAWGNEYGYHFSV 563
Cdd:cd00576 241 IDSHDERI------PTIELGGDERRTVGLGIAGVADLLIK-LGLEKVGDPEADDLAAELVDQLKKHLVKATNERGFNFLL 313
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 564 YSTPSESltdrfcrldtekfgivenITDKEYYTNSFH-------YDVRKNPTPFEKLEFEKDYPKYCSGGFIHYCEYPVL 636
Cdd:cd00576 314 GLSPSES------------------NSSGAPATNGVSpsrg*iaIVLNGDIGPEESLASVAILQFYADNGISDTITIPDS 375
|
490 500
....*....|....*....|....*.
gi 736683222 637 QQNPKALEAVWDFAYD-KVGYLGTNT 661
Cdd:cd00576 376 ATNLDQLLAVIDGAAAiKTTHVRVNP 401
|
|
| Gly_radical |
pfam01228 |
Glycine radical; |
603-708 |
1.33e-37 |
|
Glycine radical;
Pssm-ID: 426140 [Multi-domain] Cd Length: 106 Bit Score: 135.76 E-value: 1.33e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 603 VRKNPTPFEKLEFEKDYPKYCSGGFIHY-CEYPVLQQNPKALEAVWDFaYDKVGYLGTNTPIDHCYQCGFEGDFQPTERg 681
Cdd:pfam01228 1 VAPGISPSHGADFEGPTAVLNSVGKIDYeVELDGISLNQKFLPAVLGY-YDEEGYANLNTLIDTYFEGGHHLQFNVVDR- 78
|
90 100
....*....|....*....|....*..
gi 736683222 682 FECPECGNHDPKTCDVVKRTCGYLGNP 708
Cdd:pfam01228 79 ETLPDAQKHPEKYPDLTVRVSGYSANF 105
|
|
| ATP-cone |
pfam03477 |
ATP cone domain; |
20-112 |
2.30e-23 |
|
ATP cone domain;
Pssm-ID: 397513 [Multi-domain] Cd Length: 86 Bit Score: 94.64 E-value: 2.30e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 20 MTVIKRDGREVPFDEQKINAALIKAEKKihgslspiTYEKIQSIAELVIKEIKNRFANNVKIYEIQNIVEHILLEKNEYA 99
Cdd:pfam03477 1 MKVIKRDGRREPFDKEKIRRAIEKACEK--------SPDQADELASEVEEELEKSLEDGISTEEIQDLVEKTLAEHPDYA 72
|
90
....*....|...
gi 736683222 100 LAEEYIHYRTKRD 112
Cdd:pfam03477 73 VARAYILYRNLRK 85
|
|
| PRK08579 |
PRK08579 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
136-727 |
8.51e-21 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 236303 [Multi-domain] Cd Length: 625 Bit Score: 97.13 E-value: 8.51e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 136 VNENANK---DSNVFN--TQRDLtagivgKSIGLKLLPPHIANAHQKGDIHYHDLDYHPYTPMtnCCLIDFKGMLNNGFK 210
Cdd:PRK08579 24 VNENANRypgPTGFFAyvLEEAL------KESLVSLLPEPGLEAHFSGDIYIHKLPYSLYIPY--CTGHSISRLLEKGLK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 211 IGNAEVESPKSIQTATAQISQIIAnVASSQYGGCSADRTDELLA-PFAqlnykkhlidakewidtpeRQEAYAKAKTKKD 289
Cdd:PRK08579 96 TPTIISRPARHFDTFVDHVANYLI-TMQHYFTGAQAFSSVEWYAgPFI-------------------RKDGLDYRKIKQN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 290 IfdamQSLEYEINTLFTSNGQTPFTSLGFGL---------------GKNW-----FEREIQ---KAILQIRINGlGSEKR 346
Cdd:PRK08579 156 I----QRLVYNLNYPSRVGMQTPFTNFTVTLdapkkmlegdyavydGKKVgplgeYEEEAKlflLALTEVLREG-DALGQ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 347 TAIFPklIFTLKDGINLKPTDPnyDIKQLALECATKR--MY--------PDI-------LNYDKiVELTGSFKVPMGCRS 409
Cdd:PRK08579 231 PFTFP--IPTLMTTAKMLWDDP--EVFEAVFTTAAKRgsFYwlntrvvdPDAsyamccrINIDK-NELMYAFGVGGKSRR 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 410 FLQGWKDENGEEVNVGRM-----------NLGVVTLNLPRIALEADGDQEKFWQLLSDRLSIMKDALVYRVERcKEAIPA 478
Cdd:PRK08579 306 DLEDAEEEYLEKLEKQRFgglwampditgSVNVTTVNLPRIALEARGDDDKFWELYEERLELVRITLDWFRER-YVKLLK 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 479 NAPilYMYGAFgkrlsrTDAVDELFKNRRATVslGYIGLYEVAASFFG----------GAWEnnaEAKDFTLDIVKKLKA 548
Cdd:PRK08579 385 TYP--EMYSMI------KEYLEEFPSSHFNTI--GIIGLPEAAAIYLGepklwtegsrRDWL---EAAELMKKMVEFAVE 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 549 NADAWGNEYGYHFSVYSTPSESLTDRFCRLDTEKFGIVENIT---DKEYYTNSF--HYDvrknPTPF-EKLEFEKDYPKY 622
Cdd:PRK08579 452 KAREWMKETGTPWNVEEVPGESAAAKLAIKDLKLFPELREYLsdpENPIYSTSIapYYG----PLELwDRIEIEEKVQQE 527
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 623 CSGG-----FIHycEYPvlqqNPKALEA-VWDFAYDKVGYLGTNTPIDHCYQCGFegdfqpTERGF--ECPECGNHDpkt 694
Cdd:PRK08579 528 FTGGvmmhiFLG--EEP----DPEALAKlTKRIMNTKLVYWSYTPAITVCNKCGR------STTGLytRCPRCGSED--- 592
|
650 660 670
....*....|....*....|....*....|....*.
gi 736683222 695 CDVVKRTCGYLgnpqaRPMVH---GRHKEISSRvKH 727
Cdd:PRK08579 593 VEVWSRIIGYY-----RPLKNwnpYRKKEFWLR-KH 622
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
20-115 |
1.67e-12 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 70.94 E-value: 1.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 20 MTVIKRDGREVPFDEQKINAALIKAEKKIHgslSPITYEKIQSIAELVIKEIKNRFAN--NVKIYEIQNIVEHILLEKNE 97
Cdd:PRK12364 1 MEIIKRNGTTEPYDREKIEVAIRKAFASVG---KPISDEIIYSLVAEVERFIKEKYPNghNVSVEEIQDLVEKTLMEHGH 77
|
90
....*....|....*...
gi 736683222 98 YALAEEYIHYRTKRDFAR 115
Cdd:PRK12364 78 YAEVKSYILYRAQRTEKR 95
|
|
| PRK08271 |
PRK08271 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
422-727 |
7.19e-12 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 181342 [Multi-domain] Cd Length: 623 Bit Score: 68.50 E-value: 7.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 422 VNVGRMNlgVVTLNLPRIALEAdGDQEKFWQLLSDRLSIMKDALV-YRvERCKEAIPANAPILYMYGAFgkrlsrtdAVD 500
Cdd:PRK08271 346 VNTGSIN--VITINLPRIAQEA-RDRDDFLEILRERVDKIHKYQLaYR-EIMEERIAAGMLPLYDAGFI--------SLD 413
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 501 ELFknrratVSLGYIGLYEvAASFFGGAWENNAEAKDFTLDIVKKLKANADAWGNEYGYHFSVYSTPSESLT------DR 574
Cdd:PRK08271 414 KQF------LTIGINGMVE-AAEFMGLTVGYNEEYKDFVQEVLKVIYEANEKASKEYGFTFNTEFVPAENLGvklakwDR 486
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 575 FCRLDTEK------FGIVE----NITDKEYYTNsfhydvrknptpfeklefeKDYPKYCSGGFIHYC---EYPVLQQNPK 641
Cdd:PRK08271 487 EDGYGVPRqcynsySYVVEdantDALDKFKLHG-------------------KELDKYLSGGSALHLnldERLSEEGYRK 547
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 642 ALEAVwdfAYDKVGYLGTNTPIDHCYQCGfegdFQPTERGFECPECGNHDpktCDVVKRTCGYLGNPQArpMVHGRHKEI 721
Cdd:PRK08271 548 LLNIA---AKTGCNYFAFNVKITICNDCH----HIDKRTGKRCPICGSEN---IDYYTRVIGYLKRVSA--FSKVRQKEY 615
|
....*.
gi 736683222 722 SSRVKH 727
Cdd:PRK08271 616 PRRHYH 621
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
20-136 |
7.25e-10 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 62.66 E-value: 7.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 20 MTVIKRDGREVPFDEQKINAALIKAEK---KIHGSLSPITYEKIQSIAELVIKEIKNRFA--NNVKIYEIQNIVEHILLE 94
Cdd:PRK12365 118 LSVIRRDGTVVHFNPMKISAALEKAFRatdKIEGMTPSSVLEEINALTQNIVEEILECCSqeDRIDIEKIQDIVEQQLMV 197
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 736683222 95 KNEYALAEEYIHYRTKRDFAR-SKATDInfSIEKLINKDQSVV 136
Cdd:PRK12365 198 VGHYDVAKNYILYREARARVRdNKEEDG--STEKTIAEEAYEV 238
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
20-115 |
4.90e-09 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 59.86 E-value: 4.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 20 MTVIKRDGREVPFDEQKINAALIKAEKKIHGslspITYEKIQSIAELVIKEIKNRFANNVKiyEIQNIVEHILLEKNEY- 98
Cdd:PRK06406 5 KEVIKRDGTVVPFDKKKIAMAIYKAMLSVKN----GSMEDAEELTDKVVERLKKYERPTVE--QIQDIVEKVLMTKKINg 78
|
90 100
....*....|....*....|.
gi 736683222 99 ----ALAEEYIHYRTKRDFAR 115
Cdd:PRK06406 79 kdftDVAKSYILYREKRRKIR 99
|
|
| NrdR |
COG1327 |
Transcriptional regulator NrdR, contains Zn-ribbon and ATP-cone domains [Transcription]; |
16-88 |
8.72e-08 |
|
Transcriptional regulator NrdR, contains Zn-ribbon and ATP-cone domains [Transcription];
Pssm-ID: 440938 [Multi-domain] Cd Length: 153 Bit Score: 52.00 E-value: 8.72e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 736683222 16 ETKKMTVIKRDGREVPFDEQKINAALIKA-EKkihgslSPITYEKIQSIAELVIKEIKNRFANNVKIYEIQNIV 88
Cdd:COG1327 45 ELVPLMVIKKDGRREPFDREKLLRGLLRAcEK------RPVSAEQIEAAVDRIERELRASGEREVPSREIGELV 112
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
22-120 |
9.35e-08 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 55.74 E-value: 9.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 22 VIKRDGREVPFDEQKINAALIKAEKKIHGS---LSPITYEKIQSIAELVIKEIKNRFAN--NVKIYEIQNIVEHILLEKN 96
Cdd:PRK07207 36 VIRRNGSVVPFEPSKIAVAMTKAFLAVEGGqaaASARVRETVEQLTEQVVRALVRRRPSggTFHIEDIQDQVELALMRSG 115
|
90 100
....*....|....*....|....
gi 736683222 97 EYALAEEYIHYRTKRDFARSKATD 120
Cdd:PRK07207 116 EHKVARAYVLYREKRAQERAAEAE 139
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
22-133 |
2.52e-07 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 54.39 E-value: 2.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 22 VIKRDGREVPFDEQKINAALIKA--------EKKihgsLSPITYEKIQSIAELVIKEIKNrfannvkIYEIQNIVEHILL 93
Cdd:PRK08332 6 VMKRDGRIVPFDESRIRWAVQRAmwevgvrdEKK----LDEVVKRIVQRINELYDGKIPH-------IENIQDIVELELM 74
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 736683222 94 EKNEYALAEEYIHYRTKRdfarskaTDINFSIEKLINKDQ 133
Cdd:PRK08332 75 RAGLFEVAKAYILYRKKK-------AEIREEKKRILNKKE 107
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
16-144 |
1.28e-06 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 51.87 E-value: 1.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736683222 16 ETKKMTVIKRDGREVPFDEQKINAALIKAEKKI-----HGSLSPITYEKIQSIAELVIKEI--KNRFANNVKIYEIQNIV 88
Cdd:PRK12365 5 QEKQYTIVKRNGMFVPFNQNRIFQALEAAFRDTrsledHSPLPEDLESSIRSITHQVVKEVvqKITEGQVVTVERIQDMV 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 736683222 89 EHILLEKNEYALAEEYIHYRTKRDFARSKAtdinFSIEKLINKDQSVVNENANKDS 144
Cdd:PRK12365 85 ESQLYVNGLQDVARDYIVYRDDRKAHRKKS----WQSLSVIRRDGTVVHFNPMKIS 136
|
|
| HybF |
COG0375 |
Hydrogenase maturation factor HypA/HybF, metallochaperone involved in Ni insertion ... |
665-691 |
2.69e-03 |
|
Hydrogenase maturation factor HypA/HybF, metallochaperone involved in Ni insertion [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440144 Cd Length: 113 Bit Score: 38.22 E-value: 2.69e-03
10 20
....*....|....*....|....*..
gi 736683222 665 HCYQCGFEgdFQPTERGFECPECGNHD 691
Cdd:COG0375 72 RCRDCGKE--FELEELFLRCPKCGSPD 96
|
|
| |
