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Conserved domains on  [gi|736904641|ref|WP_034903397|]
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class I SAM-dependent methyltransferase [Erythrobacter litoralis]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 47-147 6.64e-15

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 70.41  E-value: 6.64e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641  47 GLRQGARLLDLATGDGRVLRWLReeRRDLDLQGIDRAP--------KLPPAPEGTATRGGiAMEDLPFADDSFDAVTSQF 118
Cdd:COG2226   19 GLRPGARVLDLGCGTGRLALALA--ERGARVTGVDISPemlelareRAAEAGLNVEFVVG-DAEDLPFPDGSFDLVISSF 95

                         90       100       110
                 ....*....|....*....|....*....|
gi 736904641 119 GFEY-GDVAAVAGEIARVLGPDGRVGLMVH 147
Cdd:COG2226   96 VLHHlPDPERALAEIARVLKPGGRLVVVDF 125
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 47-147 6.64e-15

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 70.41  E-value: 6.64e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641  47 GLRQGARLLDLATGDGRVLRWLReeRRDLDLQGIDRAP--------KLPPAPEGTATRGGiAMEDLPFADDSFDAVTSQF 118
Cdd:COG2226   19 GLRPGARVLDLGCGTGRLALALA--ERGARVTGVDISPemlelareRAAEAGLNVEFVVG-DAEDLPFPDGSFDLVISSF 95

                         90       100       110
                 ....*....|....*....|....*....|
gi 736904641 119 GFEY-GDVAAVAGEIARVLGPDGRVGLMVH 147
Cdd:COG2226   96 VLHHlPDPERALAEIARVLKPGGRLVVVDF 125
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 55-142 9.06e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 60.37  E-value: 9.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641   55 LDLATGDGRVLRWLReeRRDLDLQGIDRAPKLPPAPEGTATRGGIA-----MEDLPFADDSFDAVTSQFGFEY-GDVAAV 128
Cdd:pfam08241   1 LDVGCGTGLLTELLA--RLGARVTGVDISPEMLELAREKAPREGLTfvvgdAEDLPFPDNSFDLVLSSEVLHHvEDPERA 78

                          90
                  ....*....|....
gi 736904641  129 AGEIARVLGPDGRV 142
Cdd:pfam08241  79 LREIARVLKPGGIL 92
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 40-145 5.24e-10

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 58.43  E-value: 5.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641   40 AWRGFA---EGLRQGARLLDLATGDGRVLRWLREER-RDLDLQGIDRAPKL---------PPAP----EGTAtrggiamE 102
Cdd:TIGR01934  26 LWRRRAvklIGVFKGQKVLDVACGTGDLAIELAKSApDRGKVTGVDFSSEMlevakkkseLPLNiefiQADA-------E 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 736904641  103 DLPFADDSFDAVTSQFGFE-YGDVAAVAGEIARVLGPDGRVGLM 145
Cdd:TIGR01934  99 ALPFEDNSFDAVTIAFGLRnVTDIQKALREMYRVLKPGGRLVIL 142
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 40-155 3.92e-09

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 55.93  E-value: 3.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641  40 AWRGFA---EGLRQGARLLDLATGDGRV-LRWLREERRDLDLQGID-----------RAPKLPPAP-----EGTAtrggi 99
Cdd:PRK00216  38 VWRRKTikwLGVRPGDKVLDLACGTGDLaIALAKAVGKTGEVVGLDfsegmlavgreKLRDLGLSGnvefvQGDA----- 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 736904641 100 amEDLPFADDSFDAVTSQFG---FEygDVAAVAGEIARVLGPDGRVGlmvhrgdgpILE 155
Cdd:PRK00216 113 --EALPFPDNSFDAVTIAFGlrnVP--DIDKALREMYRVLKPGGRLV---------ILE 158
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 53-142 8.55e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 38.18  E-value: 8.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641  53 RLLDLATGDGRVLRWLREeRRDLDLQGIDRAPK-LPPAPEGTATRGGI--------AMEDLPFADDSFDAVTSQFGFEYG 123
Cdd:cd02440    1 RVLDLGCGTGALALALAS-GPGARVTGVDISPVaLELARKAAAALLADnvevlkgdAEELPPEADESFDVIISDPPLHHL 79

                         90       100
                 ....*....|....*....|.
gi 736904641 124 --DVAAVAGEIARVLGPDGRV 142
Cdd:cd02440   80 veDLARFLEEARRLLKPGGVL 100
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 47-147 6.64e-15

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 70.41  E-value: 6.64e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641  47 GLRQGARLLDLATGDGRVLRWLReeRRDLDLQGIDRAP--------KLPPAPEGTATRGGiAMEDLPFADDSFDAVTSQF 118
Cdd:COG2226   19 GLRPGARVLDLGCGTGRLALALA--ERGARVTGVDISPemlelareRAAEAGLNVEFVVG-DAEDLPFPDGSFDLVISSF 95

                         90       100       110
                 ....*....|....*....|....*....|
gi 736904641 119 GFEY-GDVAAVAGEIARVLGPDGRVGLMVH 147
Cdd:COG2226   96 VLHHlPDPERALAEIARVLKPGGRLVVVDF 125
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 55-142 9.06e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 60.37  E-value: 9.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641   55 LDLATGDGRVLRWLReeRRDLDLQGIDRAPKLPPAPEGTATRGGIA-----MEDLPFADDSFDAVTSQFGFEY-GDVAAV 128
Cdd:pfam08241   1 LDVGCGTGLLTELLA--RLGARVTGVDISPEMLELAREKAPREGLTfvvgdAEDLPFPDNSFDLVLSSEVLHHvEDPERA 78

                          90
                  ....*....|....
gi 736904641  129 AGEIARVLGPDGRV 142
Cdd:pfam08241  79 LREIARVLKPGGIL 92
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 55-140 9.73e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 57.57  E-value: 9.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641   55 LDLATGDGRVLRWLREeRRDLDLQGIDRAPKLPPAPEGTATRGGIA-------MEDLPFADDSFDAVTSQFGFEY---GD 124
Cdd:pfam13649   2 LDLGCGTGRLTLALAR-RGGARVTGVDLSPEMLERARERAAEAGLNvefvqgdAEDLPFPDGSFDLVVSSGVLHHlpdPD 80

                          90
                  ....*....|....*.
gi 736904641  125 VAAVAGEIARVLGPDG 140
Cdd:pfam13649  81 LEAALREIARVLKPGG 96
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 40-145 5.24e-10

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 58.43  E-value: 5.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641   40 AWRGFA---EGLRQGARLLDLATGDGRVLRWLREER-RDLDLQGIDRAPKL---------PPAP----EGTAtrggiamE 102
Cdd:TIGR01934  26 LWRRRAvklIGVFKGQKVLDVACGTGDLAIELAKSApDRGKVTGVDFSSEMlevakkkseLPLNiefiQADA-------E 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 736904641  103 DLPFADDSFDAVTSQFGFE-YGDVAAVAGEIARVLGPDGRVGLM 145
Cdd:TIGR01934  99 ALPFEDNSFDAVTIAFGLRnVTDIQKALREMYRVLKPGGRLVIL 142
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 44-146 2.51e-09

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 54.25  E-value: 2.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641  44 FAEGLRQGARLLDLATGDGRVLRWLReeRRDLDLQGIDRAPKLPPAPEGTATRGGIA-----MEDLPFADDSFDAVTSQF 118
Cdd:COG2227   18 LARLLPAGGRVLDVGCGTGRLALALA--RRGADVTGVDISPEALEIARERAAELNVDfvqgdLEDLPLEDGSFDLVICSE 95

                         90       100
                 ....*....|....*....|....*....
gi 736904641 119 GFEY-GDVAAVAGEIARVLGPDGRVGLMV 146
Cdd:COG2227   96 VLEHlPDPAALLRELARLLKPGGLLLLST 124
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 40-155 3.92e-09

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 55.93  E-value: 3.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641  40 AWRGFA---EGLRQGARLLDLATGDGRV-LRWLREERRDLDLQGID-----------RAPKLPPAP-----EGTAtrggi 99
Cdd:PRK00216  38 VWRRKTikwLGVRPGDKVLDLACGTGDLaIALAKAVGKTGEVVGLDfsegmlavgreKLRDLGLSGnvefvQGDA----- 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 736904641 100 amEDLPFADDSFDAVTSQFG---FEygDVAAVAGEIARVLGPDGRVGlmvhrgdgpILE 155
Cdd:PRK00216 113 --EALPFPDNSFDAVTIAFGlrnVP--DIDKALREMYRVLKPGGRLV---------ILE 158
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 44-155 5.29e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 51.66  E-value: 5.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641   44 FAEGLRQGARLLDLATGDGRVLRWLREERRDLDlqGIDRAPKLPPAPEGTATRGGIAMEDLPFADDSFDAVTSQFGFEY- 122
Cdd:pfam13489  16 LLPKLPSPGRVLDFGCGTGIFLRLLRAQGFSVT--GVDPSPIAIERALLNVRFDQFDEQEAAVPAGKFDVIVAREVLEHv 93

                          90       100       110
                  ....*....|....*....|....*....|...
gi 736904641  123 GDVAAVAGEIARVLGPDGRVGLMVHRGDGPILE 155
Cdd:pfam13489  94 PDPPALLRQIAALLKPGGLLLLSTPLASDEADR 126
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
9-151 1.94e-07

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 50.38  E-value: 1.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641   9 AWGEFWKANAGGDSTGCLPERWAAiETAQRAawrgfaeGLRQGARLLDLATGDGRVLRWLREERRDLDlqGIDRAPKlpp 88
Cdd:COG4976   13 QYADSYDAALVEDLGYEAPALLAE-ELLARL-------PPGPFGRVLDLGCGTGLLGEALRPRGYRLT--GVDLSEE--- 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641  89 APEGTATRGGIA------MEDLPFADDSFDAVTSQFGFEY-GDVAAVAGEIARVLGPDGRVGLMVHRGDG 151
Cdd:COG4976   80 MLAKAREKGVYDrllvadLADLAEPDGRFDLIVAADVLTYlGDLAAVFAGVARALKPGGLFIFSVEDADG 149
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 22-144 9.86e-07

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 47.62  E-value: 9.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641  22 STGCLPERWAAIETAQRAAWRGFAE--GLRQGARLLDLATGDGRVLRWLReERRDLDLQGIDRAPKLPPAPEGTATRGGI 99
Cdd:COG2230   21 SCAYFEDPDDTLEEAQEAKLDLILRklGLKPGMRVLDIGCGWGGLALYLA-RRYGVRVTGVTLSPEQLEYARERAAEAGL 99

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 736904641 100 A---------MEDLPfADDSFDAVTSQFGFEY---GDVAAVAGEIARVLGPDGRVGL 144
Cdd:COG2230  100 AdrvevrladYRDLP-ADGQFDAIVSIGMFEHvgpENYPAYFAKVARLLKPGGRLLL 155
MetW pfam07021
Methionine biosynthesis protein MetW; This family consists of several bacterial and one ...
 38-114 1.10e-06

Methionine biosynthesis protein MetW; This family consists of several bacterial and one archaeal methionine biosynthesis MetW proteins. Biosynthesis of methionine from homoserine in Pseudomonas putida takes place in three steps. The first step is the acylation of homoserine to yield an acyl-L-homoserine. This reaction is catalyzed by the products of the metXW genes and is equivalent to the first step in enterobacteria, gram-positive bacteria and fungi, except that in these microorganizms the reaction is catalyzed by a single polypeptide (the product of the metA gene in Escherichia coli and the met5 gene product in Neurospora crassa). In Pseudomonas putida, as in gram-positive bacteria and certain fungi, the second and third steps are a direct sulfhydrylation that converts the O-acyl-L-homoserine into homocysteine and further methylation to yield methionine. The latter reaction can be mediated by either of the two methionine synthetases present in the cells.


Pssm-ID: 399779  Cd Length: 193  Bit Score: 48.22  E-value: 1.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641   38 RAAWRGFAEGLRQGARLLDLATGDGRVLRWLREErRDLDLQGI--DRAPKLPPAPEGTATRGGIAMEDLP-FADDSFDAV 114
Cdd:pfam07021   1 RADFRYILEWIPPGSRVLDLGCGDGTLLYLLKEE-KGVDGYGIelDAAGVAECVAKGLYVIQGDLDEGLEhFPDKSFDYV 79
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
41-142 2.05e-06

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 47.82  E-value: 2.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641   41 WRGFAE---GLRQGARLLDLATGDGRV-LRWLREERRDLDLQGIDRAPKLPPAPEGTATRGGI---------AMEdLPFA 107
Cdd:pfam01209  30 WKDFTMkcmGVKRGNKFLDVAGGTGDWtFGLSDSAGSSGKVVGLDINENMLKEGEKKAKEEGKynieflqgnAEE-LPFE 108

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 736904641  108 DDSFDAVTSQFGFE-YGDVAAVAGEIARVLGPDGRV 142
Cdd:pfam01209 109 DDSFDIVTISFGLRnFPDYLKVLKEAFRVLKPGGRV 144
PRK08317 PRK08317
hypothetical protein; Provisional
 48-165 2.71e-06

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 47.62  E-value: 2.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641  48 LRQGARLLDLATGDGRVLRWL-REERRDLDLQGIDRAPK-LPPAPEGTATRGGIA------MEDLPFADDSFDAVTSQFG 119
Cdd:PRK08317  17 VQPGDRVLDVGCGPGNDARELaRRVGPEGRVVGIDRSEAmLALAKERAAGLGPNVefvrgdADGLPFPDGSFDAVRSDRV 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 736904641 120 FEY-GDVAAVAGEIARVLGPDGRVGLMVHRGDGPILE-HNRARRSAIL 165
Cdd:PRK08317  97 LQHlEDPARALAEIARVLRPGGRVVVLDTDWDTLVWHsGDRALMRKIL 144
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 55-142 5.07e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 41.58  E-value: 5.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641   55 LDLATGDGRVLRWLREERRDLDLQGIDRAP--------KLPPAPEGTATRGGIAMEDLPFADD-SFDAVTSQFGFEY-GD 124
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPaaleaareRLAALGLLNAVRVELFQLDLGELDPgSFDVVVASNVLHHlAD 80

                          90
                  ....*....|....*...
gi 736904641  125 VAAVAGEIARVLGPDGRV 142
Cdd:pfam08242  81 PRAVLRNIRRLLKPGGVL 98
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
50-142 3.97e-04

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 39.04  E-value: 3.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641  50 QGARLLDLATGDGRVLRWLREERRDLDLQGIDRAP--------KLPPApegTATRGgiAMEDLPFaDDSFDAVTSQFGFE 121
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPemlararaRLPNV---RFVVA--DLRDLDP-PEPFDLVVSNAALH 74

                         90       100
                 ....*....|....*....|..
gi 736904641 122 Y-GDVAAVAGEIARVLGPDGRV 142
Cdd:COG4106   75 WlPDHAALLARLAAALAPGGVL 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 53-142 8.55e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 38.18  E-value: 8.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641  53 RLLDLATGDGRVLRWLREeRRDLDLQGIDRAPK-LPPAPEGTATRGGI--------AMEDLPFADDSFDAVTSQFGFEYG 123
Cdd:cd02440    1 RVLDLGCGTGALALALAS-GPGARVTGVDISPVaLELARKAAAALLADnvevlkgdAEELPPEADESFDVIISDPPLHHL 79

                         90       100
                 ....*....|....*....|.
gi 736904641 124 --DVAAVAGEIARVLGPDGRV 142
Cdd:cd02440   80 veDLARFLEEARRLLKPGGVL 100
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 37-183 1.84e-03

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 39.10  E-value: 1.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641  37 QRAAWRGFA---EGLRQGARLLDLATGDGRvLRWLREERRDLD--LQGID-RAPKLPPAP-----------------EGT 93
Cdd:PLN02233  57 QHRIWKRMAvswSGAKMGDRVLDLCCGSGD-LAFLLSEKVGSDgkVMGLDfSSEQLAVAAsrqelkakscykniewiEGD 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641  94 ATrggiameDLPFADDSFDAVTSQFGFE-YGDVAAVAGEIARVLGPDGRVGlmvhrgdgpILEHNRARRSAIL----WAI 168
Cdd:PLN02233 136 AT-------DLPFDDCYFDAITMGYGLRnVVDRLKAMQEMYRVLKPGSRVS---------ILDFNKSTQPFTTsmqeWMI 199

                        170
                 ....*....|....*
gi 736904641 169 EEKAVPATVIRALHD 183
Cdd:PLN02233 200 DNVVVPVATGYGLAK 214
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
104-146 2.47e-03

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 37.92  E-value: 2.47e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 736904641 104 LPFADDSFDAVTSQFGFE---YGDVAAVAGEIARVLGPDGRVGLMV 146
Cdd:COG4627   40 LPFPDNSVDAIYSSHVLEhldYEEAPLALKECYRVLKPGGILRIVV 85
PLN02232 PLN02232
ubiquinone biosynthesis methyltransferase
 103-181 5.18e-03

ubiquinone biosynthesis methyltransferase


Pssm-ID: 165876  Cd Length: 160  Bit Score: 36.98  E-value: 5.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641 103 DLPFADDSFDAVTSQFGFE-YGDVAAVAGEIARVLGPDGRVGlmvhrgdgpILEHNRARRSAIL----WAIEEKAVPATV 177
Cdd:PLN02232  37 DLPFDDCEFDAVTMGYGLRnVVDRLRAMKEMYRVLKPGSRVS---------ILDFNKSNQSVTTfmqgWMIDNVVVPVAT 107


                 ....
gi 736904641 178 IRAL 181
Cdd:PLN02232 108 VYDL 111
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 28-148 5.47e-03

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 37.20  E-value: 5.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904641  28 ERWAAIETAQRAAWRGFAEGLRQGARLLDLATGDGRVLRWLREERR------DLDLQGIDRAPKLPPApegtATRGGI-- 99
Cdd:COG0500    4 SYYSDELLPGLAALLALLERLPKGGRVLDLGCGTGRNLLALAARFGgrvigiDLSPEAIALARARAAK----AGLGNVef 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 736904641 100 ----AMEDLPFADDSFDAVTSQFGFEY---GDVAAVAGEIARVLGPDGRVGLMVHR 148
Cdd:COG0500   80 lvadLAELDPLPAESFDLVVAFGVLHHlppEEREALLRELARALKPGGVLLLSASD 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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