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Conserved domains on  [gi|736904747|ref|WP_034903498|]
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UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [Erythrobacter litoralis]

Protein Classification

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase( domain architecture ID 11478177)

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan

CATH:  3.40.1390.10|3.40.1190.10|3.90.190.20
EC:  6.3.2.13
Gene Ontology:  GO:0005524|GO:0008765|GO:0009252|GO:0000287
PubMed:  11124264|28201974
SCOP:  4000234

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
murE PRK00139
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
 1-498 4.39e-173

UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional


:

Pssm-ID: 234660 [Multi-domain]  Cd Length: 460  Bit Score: 495.42  E-value: 4.39e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747   1 MRLSALLeaaglepagewSDAAVSGFAIDHRKVAPGTVFGAFRGERFNAEDVIPQAIEAGAVAVVASPEAR-VEGAAHVA 79
Cdd:PRK00139   4 MKLRDLL-----------APVEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEADGEaGTGVPVII 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  80 SEEPRRAFARLAARFFEPVPE--TLVAVTGTNGKTSTAEMTRQIWRMCGRSAASIGTLGVTTPDGSVSTGLTTPDIVTFL 157
Cdd:PRK00139  73 VPDLRKALALLAAAFYGHPSDklKLIGVTGTNGKTTTAYLLAQILRLLGEKTALIGTLGNGIGGELIPSGLTTPDALDLQ 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 158 ANMAGLAREGVTHVAYEASSHGLAQYRNEGLTLAASAFTNFSRDHLDYHGTMEAYFEAKMRLFDEvaqPASPAVIFdggR 237
Cdd:PRK00139 153 RLLAELVDAGVTYAAMEVSSHALDQGRVDGLKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLFSE---LGLAAVIN---A 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 238 DEVWIPKAIERAKARGldvrsVGEKGRFLRLTAREATQLGQVLTVEFEgsartIKLPLIGEYQAANALVAAGLALSTGCE 317
Cdd:PRK00139 227 DDEVGRRLLALPDAYA-----VSMAGADLRATDVEYTDSGQTFTLVTE-----VESPLIGRFNVSNLLAALAALLALGVP 296

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 318 AGQVFDALSRLQPVRGRLERAAiAPVGAPVYVDYAHTPDAMEAAIAALRGHVDdargGRLTVVFGAGGDRDPGKRAPMGD 397
Cdd:PRK00139 297 LEDALAALAKLQGVPGRMERVD-AGQGPLVIVDYAHTPDALEKVLEALRPHAK----GRLICVFGCGGDRDKGKRPLMGA 371

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 398 VAARGAERVIVTDDNPRGEDAGAIRAAILEGARgaggeaeiIEVAGRRDAIAEAIAGAGDHDIILVAGKGHEQGQIIGSg 477
Cdd:PRK00139 372 IAERLADVVIVTSDNPRSEDPAAIIADILAGIY--------DVIEDRAEAIRYAIAQAKPGDVVLIAGKGHEDYQIIGG- 442

                        490       500
                 ....*....|....*....|.
gi 736904747 478 ddmRVLPFDDVEVARECAGRR 498
Cdd:PRK00139 443 ---VKIPFDDREVAREALAER 460
 
Name Accession Description Interval E-value
murE PRK00139
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
 1-498 4.39e-173

UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional


Pssm-ID: 234660 [Multi-domain]  Cd Length: 460  Bit Score: 495.42  E-value: 4.39e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747   1 MRLSALLeaaglepagewSDAAVSGFAIDHRKVAPGTVFGAFRGERFNAEDVIPQAIEAGAVAVVASPEAR-VEGAAHVA 79
Cdd:PRK00139   4 MKLRDLL-----------APVEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEADGEaGTGVPVII 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  80 SEEPRRAFARLAARFFEPVPE--TLVAVTGTNGKTSTAEMTRQIWRMCGRSAASIGTLGVTTPDGSVSTGLTTPDIVTFL 157
Cdd:PRK00139  73 VPDLRKALALLAAAFYGHPSDklKLIGVTGTNGKTTTAYLLAQILRLLGEKTALIGTLGNGIGGELIPSGLTTPDALDLQ 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 158 ANMAGLAREGVTHVAYEASSHGLAQYRNEGLTLAASAFTNFSRDHLDYHGTMEAYFEAKMRLFDEvaqPASPAVIFdggR 237
Cdd:PRK00139 153 RLLAELVDAGVTYAAMEVSSHALDQGRVDGLKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLFSE---LGLAAVIN---A 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 238 DEVWIPKAIERAKARGldvrsVGEKGRFLRLTAREATQLGQVLTVEFEgsartIKLPLIGEYQAANALVAAGLALSTGCE 317
Cdd:PRK00139 227 DDEVGRRLLALPDAYA-----VSMAGADLRATDVEYTDSGQTFTLVTE-----VESPLIGRFNVSNLLAALAALLALGVP 296

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 318 AGQVFDALSRLQPVRGRLERAAiAPVGAPVYVDYAHTPDAMEAAIAALRGHVDdargGRLTVVFGAGGDRDPGKRAPMGD 397
Cdd:PRK00139 297 LEDALAALAKLQGVPGRMERVD-AGQGPLVIVDYAHTPDALEKVLEALRPHAK----GRLICVFGCGGDRDKGKRPLMGA 371

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 398 VAARGAERVIVTDDNPRGEDAGAIRAAILEGARgaggeaeiIEVAGRRDAIAEAIAGAGDHDIILVAGKGHEQGQIIGSg 477
Cdd:PRK00139 372 IAERLADVVIVTSDNPRSEDPAAIIADILAGIY--------DVIEDRAEAIRYAIAQAKPGDVVLIAGKGHEDYQIIGG- 442

                        490       500
                 ....*....|....*....|.
gi 736904747 478 ddmRVLPFDDVEVARECAGRR 498
Cdd:PRK00139 443 ---VKIPFDDREVAREALAER 460
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 25-497 1.00e-170

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 489.20  E-value: 1.00e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  25 GFAIDHRKVAPGTVFGAFRGERFNAEDVIPQAIEAGAVAVVASPEA----------RVEGAAHVASE-------EPRRaf 87
Cdd:COG0769    1 GITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEAPGallaagvpviVVPDPRAALALlaaafygHPSQ-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  88 arlaarffepvPETLVAVTGTNGKTSTAEMTRQIWRMCGRSAASIGTLGVTTPDGSVSTGLTTPDIVTFLANMAGLAREG 167
Cdd:COG0769   79 -----------KLKLIGVTGTNGKTTTTYLLAQILRALGKKTGLIGTVGNGIGGELIPSSLTTPEALDLQRLLAEMVDAG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 168 VTHVAYEASSHGLAQYRNEGLTLAASAFTNFSRDHLDYHGTMEAYFEAKMRLFDEVAqPASPAVIFdggRDEVWIPKAIE 247
Cdd:COG0769  148 VTHVVMEVSSHALDQGRVDGVRFDVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLG-PGGAAVIN---ADDPYGRRLAA 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 248 RAKARgldVRSVG-EKGRFLRLTAREATQLGQVLTVEFEGSARTIKLPLIGEYQAANALVAAGLALSTGCEAGQVFDALS 326
Cdd:COG0769  224 AAPAR---VITYGlKADADLRATDIELSADGTRFTLVTPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALE 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 327 RLQPVRGRLERAAiAPVGAPVYVDYAHTPDAMEAAIAALRGHvddaRGGRLTVVFGAGGDRDPGKRAPMGDVAARGAERV 406
Cdd:COG0769  301 KLKGVPGRMERVD-GGQGPTVIVDYAHTPDALENVLEALRPH----TKGRLIVVFGCGGDRDRGKRPLMGEIAARLADVV 375

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 407 IVTDDNPRGEDAGAIRAAILEGARGAGgeaEIIEVAGRRDAIAEAIAGAGDHDIILVAGKGHEQGQIIGSgddmRVLPFD 486
Cdd:COG0769  376 IVTSDNPRSEDPAAIIADILAGIPGAG---KVLVIPDRAEAIRYAIALAKPGDVVLIAGKGHETYQIIGG----VKIPFD 448

                        490
                 ....*....|.
gi 736904747 487 DVEVARECAGR 497
Cdd:COG0769  449 DREVAREALAE 459
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
 20-487 1.92e-123

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 368.95  E-value: 1.92e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747   20 DAAVSGFAIDHRKVAPGTVFGAFRGERFNAEDVIPQAIEAGAVAVVASPEA----------RVEGAAHVASEEprrafar 89
Cdd:TIGR01085   1 DLEVTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVdfyvapvpviIVPDLRHALSSL------- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747   90 LAARFFEPVPE-TLVAVTGTNGKTSTAEMTRQIWRMCGRSAASIGTLGVTTPDGSVS---TGLTTPDIVTFLANMAGLAR 165
Cdd:TIGR01085  74 AAAFYGHPSKKlKVIGVTGTNGKTTTTSLIAQLLRLLGKKTGLIGTIGYRLGGNDLIknpAALTTPEALTLQSTLAEMVE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  166 EGVTHVAYEASSHGLAQYRNEGLTLAASAFTNFSRDHLDYHGTMEAYFEAKMRLFDEVAQPASPAVIFDGGRDEVWIPKA 245
Cdd:TIGR01085 154 AGAQYAVMEVSSHALAQGRVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTELGLKRFAVINLDDEYGAQFVKRL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  246 IERAKARGLDVRSVGEKGrFLRLTAREATQLGQVLTVEFEGSARTIKLPLIGEYQAANALVA-AGLALSTGCEAGQVFDA 324
Cdd:TIGR01085 234 PKDITVSAITQPADGRAQ-DIKITDSGYSFEGQQFTFETPAGEGHLHTPLIGRFNVYNLLAAlATLLHLGGIDLEDIVAA 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  325 LSRLQPVRGRLERAAIAPvGAPVYVDYAHTPDAMEAAIAALRGHvddaRGGRLTVVFGAGGDRDPGKRAPMGDVAARGAE 404
Cdd:TIGR01085 313 LEKFRGVPGRMELVDGGQ-KFLVIVDYAHTPDALEKALRTLRKH----KDGRLIVVFGCGGDRDRGKRPLMGAIAEQLAD 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  405 RVIVTDDNPRGEDAGAIRAAILEGARGAGgeaEIIEVAGRRDAIAEAIAGAGDHDIILVAGKGHEQGQIIGSgddmRVLP 484
Cdd:TIGR01085 388 LVILTSDNPRGEDPEQIIADILAGISEKE---KVVIIADRRQAIRYAISNAKAGDVVLIAGKGHEDYQIIGG----ETIP 460


                  ...
gi 736904747  485 FDD 487
Cdd:TIGR01085 461 FDD 463
Mur_ligase_M pfam08245
Mur ligase middle domain;
105-311 5.64e-49

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 167.10  E-value: 5.64e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  105 VTGTNGKTSTAEMTRQIWRMCGRSAASIGTLGVttpdgsvSTGLTTPDIVTFLANMAGLAREGVTHVAYEASSHGLAQYR 184
Cdd:pfam08245   1 VTGTNGKTTTTELIAAILSLAGGVIGTIGTYIG-------KSGNTTNNAIGLPLTLAEMVEAGAEYAVLEVSSHGLGEGR 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  185 NEGLT-LAASAFTNFSRDHLDYHGTMEAYFEAKMRLFDEVaQPASPAVIFdggRDEVWIPKAIERAKARGLDVRSVGEKG 263
Cdd:pfam08245  74 LSGLLkPDIAVFTNISPDHLDFHGTMENYAKAKAELFEGL-PEDGIAVIN---ADDPYGAFLIAKLKKAGVRVITYGIEG 149

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 736904747  264 RF-LRLTAREATQLGQVLTV-EFEGSARTIKLPLIGEYQAANALVAAGLA 311
Cdd:pfam08245 150 EAdLRAANIELSSDGTSFDLfTVPGGELEIEIPLLGRHNVYNALAAIAAA 199
 
Name Accession Description Interval E-value
murE PRK00139
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
 1-498 4.39e-173

UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional


Pssm-ID: 234660 [Multi-domain]  Cd Length: 460  Bit Score: 495.42  E-value: 4.39e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747   1 MRLSALLeaaglepagewSDAAVSGFAIDHRKVAPGTVFGAFRGERFNAEDVIPQAIEAGAVAVVASPEAR-VEGAAHVA 79
Cdd:PRK00139   4 MKLRDLL-----------APVEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEADGEaGTGVPVII 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  80 SEEPRRAFARLAARFFEPVPE--TLVAVTGTNGKTSTAEMTRQIWRMCGRSAASIGTLGVTTPDGSVSTGLTTPDIVTFL 157
Cdd:PRK00139  73 VPDLRKALALLAAAFYGHPSDklKLIGVTGTNGKTTTAYLLAQILRLLGEKTALIGTLGNGIGGELIPSGLTTPDALDLQ 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 158 ANMAGLAREGVTHVAYEASSHGLAQYRNEGLTLAASAFTNFSRDHLDYHGTMEAYFEAKMRLFDEvaqPASPAVIFdggR 237
Cdd:PRK00139 153 RLLAELVDAGVTYAAMEVSSHALDQGRVDGLKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLFSE---LGLAAVIN---A 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 238 DEVWIPKAIERAKARGldvrsVGEKGRFLRLTAREATQLGQVLTVEFEgsartIKLPLIGEYQAANALVAAGLALSTGCE 317
Cdd:PRK00139 227 DDEVGRRLLALPDAYA-----VSMAGADLRATDVEYTDSGQTFTLVTE-----VESPLIGRFNVSNLLAALAALLALGVP 296

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 318 AGQVFDALSRLQPVRGRLERAAiAPVGAPVYVDYAHTPDAMEAAIAALRGHVDdargGRLTVVFGAGGDRDPGKRAPMGD 397
Cdd:PRK00139 297 LEDALAALAKLQGVPGRMERVD-AGQGPLVIVDYAHTPDALEKVLEALRPHAK----GRLICVFGCGGDRDKGKRPLMGA 371

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 398 VAARGAERVIVTDDNPRGEDAGAIRAAILEGARgaggeaeiIEVAGRRDAIAEAIAGAGDHDIILVAGKGHEQGQIIGSg 477
Cdd:PRK00139 372 IAERLADVVIVTSDNPRSEDPAAIIADILAGIY--------DVIEDRAEAIRYAIAQAKPGDVVLIAGKGHEDYQIIGG- 442

                        490       500
                 ....*....|....*....|.
gi 736904747 478 ddmRVLPFDDVEVARECAGRR 498
Cdd:PRK00139 443 ---VKIPFDDREVAREALAER 460
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 25-497 1.00e-170

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 489.20  E-value: 1.00e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  25 GFAIDHRKVAPGTVFGAFRGERFNAEDVIPQAIEAGAVAVVASPEA----------RVEGAAHVASE-------EPRRaf 87
Cdd:COG0769    1 GITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEAPGallaagvpviVVPDPRAALALlaaafygHPSQ-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  88 arlaarffepvPETLVAVTGTNGKTSTAEMTRQIWRMCGRSAASIGTLGVTTPDGSVSTGLTTPDIVTFLANMAGLAREG 167
Cdd:COG0769   79 -----------KLKLIGVTGTNGKTTTTYLLAQILRALGKKTGLIGTVGNGIGGELIPSSLTTPEALDLQRLLAEMVDAG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 168 VTHVAYEASSHGLAQYRNEGLTLAASAFTNFSRDHLDYHGTMEAYFEAKMRLFDEVAqPASPAVIFdggRDEVWIPKAIE 247
Cdd:COG0769  148 VTHVVMEVSSHALDQGRVDGVRFDVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLG-PGGAAVIN---ADDPYGRRLAA 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 248 RAKARgldVRSVG-EKGRFLRLTAREATQLGQVLTVEFEGSARTIKLPLIGEYQAANALVAAGLALSTGCEAGQVFDALS 326
Cdd:COG0769  224 AAPAR---VITYGlKADADLRATDIELSADGTRFTLVTPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALE 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 327 RLQPVRGRLERAAiAPVGAPVYVDYAHTPDAMEAAIAALRGHvddaRGGRLTVVFGAGGDRDPGKRAPMGDVAARGAERV 406
Cdd:COG0769  301 KLKGVPGRMERVD-GGQGPTVIVDYAHTPDALENVLEALRPH----TKGRLIVVFGCGGDRDRGKRPLMGEIAARLADVV 375

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 407 IVTDDNPRGEDAGAIRAAILEGARGAGgeaEIIEVAGRRDAIAEAIAGAGDHDIILVAGKGHEQGQIIGSgddmRVLPFD 486
Cdd:COG0769  376 IVTSDNPRSEDPAAIIADILAGIPGAG---KVLVIPDRAEAIRYAIALAKPGDVVLIAGKGHETYQIIGG----VKIPFD 448

                        490
                 ....*....|.
gi 736904747 487 DVEVARECAGR 497
Cdd:COG0769  449 DREVAREALAE 459
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
 20-487 1.92e-123

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 368.95  E-value: 1.92e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747   20 DAAVSGFAIDHRKVAPGTVFGAFRGERFNAEDVIPQAIEAGAVAVVASPEA----------RVEGAAHVASEEprrafar 89
Cdd:TIGR01085   1 DLEVTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVdfyvapvpviIVPDLRHALSSL------- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747   90 LAARFFEPVPE-TLVAVTGTNGKTSTAEMTRQIWRMCGRSAASIGTLGVTTPDGSVS---TGLTTPDIVTFLANMAGLAR 165
Cdd:TIGR01085  74 AAAFYGHPSKKlKVIGVTGTNGKTTTTSLIAQLLRLLGKKTGLIGTIGYRLGGNDLIknpAALTTPEALTLQSTLAEMVE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  166 EGVTHVAYEASSHGLAQYRNEGLTLAASAFTNFSRDHLDYHGTMEAYFEAKMRLFDEVAQPASPAVIFDGGRDEVWIPKA 245
Cdd:TIGR01085 154 AGAQYAVMEVSSHALAQGRVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTELGLKRFAVINLDDEYGAQFVKRL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  246 IERAKARGLDVRSVGEKGrFLRLTAREATQLGQVLTVEFEGSARTIKLPLIGEYQAANALVA-AGLALSTGCEAGQVFDA 324
Cdd:TIGR01085 234 PKDITVSAITQPADGRAQ-DIKITDSGYSFEGQQFTFETPAGEGHLHTPLIGRFNVYNLLAAlATLLHLGGIDLEDIVAA 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  325 LSRLQPVRGRLERAAIAPvGAPVYVDYAHTPDAMEAAIAALRGHvddaRGGRLTVVFGAGGDRDPGKRAPMGDVAARGAE 404
Cdd:TIGR01085 313 LEKFRGVPGRMELVDGGQ-KFLVIVDYAHTPDALEKALRTLRKH----KDGRLIVVFGCGGDRDRGKRPLMGAIAEQLAD 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  405 RVIVTDDNPRGEDAGAIRAAILEGARGAGgeaEIIEVAGRRDAIAEAIAGAGDHDIILVAGKGHEQGQIIGSgddmRVLP 484
Cdd:TIGR01085 388 LVILTSDNPRGEDPEQIIADILAGISEKE---KVVIIADRRQAIRYAISNAKAGDVVLIAGKGHEDYQIIGG----ETIP 460


                  ...
gi 736904747  485 FDD 487
Cdd:TIGR01085 461 FDD 463
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 1-501 1.29e-107

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 342.07  E-value: 1.29e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747   1 MRLSALLEA-AGLEPAGewsdAAVSGFAIDHRKVAPGTVFGAFRGERFNAEDVIPQAIEAGAVAVVA-SPEARVEGAAH- 77
Cdd:PRK11929  10 VKLEELLQAlAWLRGCV----AATADLRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVeAEGEDQVAAADa 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  78 ----VASEEPRRAFARLAARFFEPVPETLVAVTGTNGKTSTAEMTRQIWRMCGRSAASIGTLGVTTPDGSVSTGLTTPDI 153
Cdd:PRK11929  86 lvlpVADLRKALGELAARWYGRPSEQLSLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGARLDGRLIPGSLTTPDA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 154 VTFLANMAGLAREGVTHVAYEASSHGLAQYRNEGLTLAASAFTNFSRDHLDYHGTMEAYFEAKMRLFDEVAqPASPAVIf 233
Cdd:PRK11929 166 IILHRILARMRAAGADAVAMEASSHGLEQGRLDGLRIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLP-GLGAAVI- 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 234 dgGRDEVWIPKAIERAKARGLDVRSVGEKGRFLRLTAREATQLGQVLTVEFEGSARTIKLPLIGEYQAANALVAAGLALS 313
Cdd:PRK11929 244 --NADDPAAARLLAALPRGLKVGYSPQNAGADVQARDLRATAHGQVFTLATPDGSYQLVTRLLGRFNVSNLLLVAAALKK 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 314 TGCEAGQVFDALSRLQPVRGRLERAAIAPV--GAPVYVDYAHTPDAMEAAIAALRGhVDDARGGRLTVVFGAGGDRDPGK 391
Cdd:PRK11929 322 LGLPLAQIARALAAVSPVPGRMERVGPTAGaqGPLVVVDYAHTPDALAKALTALRP-VAQARNGRLVCVFGCGGDRDKGK 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 392 RAPMGDVAARGAERVIVTDDNPRGEDAGAIRAAILegaRGAGGEAEIIEVAGRRDAIAEAIAGAGDHDIILVAGKGHEQG 471
Cdd:PRK11929 401 RPEMGRIAAELADRVVVTSDNPRSEAPEAIIDQIL---AGIPAGARVFVISDRAEAIRQAIWMAAPGDVILIAGKGHETY 477

                        490       500       510
                 ....*....|....*....|....*....|
gi 736904747 472 QIIGSgddmRVLPFDDVEVARECAGRRNRD 501
Cdd:PRK11929 478 QEIGG----RKLFFDDREWARRALLARISS 503
PRK14022 PRK14022
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
18-474 1.73e-54

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;


Pssm-ID: 237588 [Multi-domain]  Cd Length: 481  Bit Score: 190.25  E-value: 1.73e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  18 WSDAAVSGFAIDHRKVAPGTVFGAfRGERFNAEdVIPQAIEAGAVAVVASPEARVEGAAHVASEEPRRAFARLAARFFEP 97
Cdd:PRK14022  29 YSGVQFDDISYDSRTADEGTLFFA-KGAYFKHK-FLQNAITQGLKLYVSEKDYEVGIPQVIVPDIKKAMSLIAMEFYDNP 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  98 VPE-TLVAVTGTNGKTSTAEMTRQIWRMCGRSAASIGTlgVTTPDGSVST--GLTTPDIVTFLANMAGLAREGVTHVAYE 174
Cdd:PRK14022 107 QHKlKLLAFTGTKGKTTAAYFAYHILKQLHKPAMLSTM--NTTLDGETFFksALTTPESLDLFKMMAEAVDNGMTHLIME 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 175 ASSHGLAQYRNEGLTLAASAFTNFSRDHLDY--HGTMEAYFEAKMRLFDEvaqpaSPAVIFDGGRDEVwipkAIERAKAR 252
Cdd:PRK14022 185 VSSQAYLVGRVYGLTFDVGVFLNITPDHIGPieHPTFEDYFYHKRLLMEN-----SKAVVVNSDMDHF----SELLEQVT 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 253 GLDVRSVGekgrflrltAREATQLGQVLTVEFEGS---ARTIKLPLIGEYQAANAlVAAGLA-LSTGCEAGQVFDALSRl 328
Cdd:PRK14022 256 PQEHDFYG---------IDSENQIMASNAFSFEATgklAGTYDIQLIGKFNQENA-MAAGLAcLRLGASLEDIQKGIAQ- 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 329 QPVRGRLErAAIAPVGAPVYVDYAHTPDAMEAAIAALRGHVDdargGRLTVVFGAGGDRDPGKRAPMGDVAARGAE-RVI 407
Cdd:PRK14022 325 TPVPGRME-VLTQSNGAKVFIDYAHNGDSLNKLIDVVEEHQK----GKLILLLGAAGNKGESRRPDFGRVANRHPYlQVI 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 736904747 408 VTDDNPRGEDAGAIRAAIlegARGAGGEAEIIevAGRRDA-IAEAIAGAGDHDIILVAGKGHEQGQII 474
Cdd:PRK14022 400 LTADDPNNEDPKMITQEI---ASHITHPVEII--DDRAEAiKHAMSITEGPGDAVIIAGKGADAYQIV 462
Mur_ligase_M pfam08245
Mur ligase middle domain;
105-311 5.64e-49

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 167.10  E-value: 5.64e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  105 VTGTNGKTSTAEMTRQIWRMCGRSAASIGTLGVttpdgsvSTGLTTPDIVTFLANMAGLAREGVTHVAYEASSHGLAQYR 184
Cdd:pfam08245   1 VTGTNGKTTTTELIAAILSLAGGVIGTIGTYIG-------KSGNTTNNAIGLPLTLAEMVEAGAEYAVLEVSSHGLGEGR 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  185 NEGLT-LAASAFTNFSRDHLDYHGTMEAYFEAKMRLFDEVaQPASPAVIFdggRDEVWIPKAIERAKARGLDVRSVGEKG 263
Cdd:pfam08245  74 LSGLLkPDIAVFTNISPDHLDFHGTMENYAKAKAELFEGL-PEDGIAVIN---ADDPYGAFLIAKLKKAGVRVITYGIEG 149

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 736904747  264 RF-LRLTAREATQLGQVLTV-EFEGSARTIKLPLIGEYQAANALVAAGLA 311
Cdd:pfam08245 150 EAdLRAANIELSSDGTSFDLfTVPGGELEIEIPLLGRHNVYNALAAIAAA 199
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 1-382 7.15e-38

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 144.09  E-value: 7.15e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747   1 MRLSALLEAAGLEPAGEwSDAAVSGFAIDHRKVAPGTVFGAFRGERFNAEDVIPQAIEAGAVAVVASpEARVEGAAHVAs 80
Cdd:COG0770    3 LTLAEIAEATGGRLIGD-PDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVS-RPLPADLPLIV- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  81 eeprrafarlaarffepVPETL------------------VAVTGTNGKTSTAEMTRQIWRMCGRSAASIGTL----GVt 138
Cdd:COG0770   80 -----------------VDDTLkalqqlaaahrarfnipvIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFnneiGV- 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 139 tPdgsvstgLTtpdivtfLANMAGLAREGVthvaYEAS-SHglaqyRNEGLTLAASA------FTNFSRDHLDYHGTMEA 211
Cdd:COG0770  142 -P-------LT-------LLRLPEDHEFAV----LEMGmNH-----PGEIAYLARIArpdiavITNIGPAHLEGFGSLEG 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 212 YFEAKMRLFDEVaqPASPAVIFDGgrDEVWIPKAIERAKARgldVRSVGEKGR-FLRLTAREATQLGQVLTVEFEGSART 290
Cdd:COG0770  198 IARAKGEIFEGL--PPGGVAVLNA--DDPLLAALAERAKAR---VLTFGLSEDaDVRAEDIELDEDGTRFTLHTPGGELE 270

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 291 IKLPLIGEYQAANALVAAGLALSTGCEAGQVFDALSRLQPVRGRLERAAIAPvGAPVYVD-YAHTPDAMEAAIAALRGHv 369
Cdd:COG0770  271 VTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVIEGAG-GVTLIDDsYNANPDSMKAALDVLAQL- 348

                        410
                 ....*....|...
gi 736904747 370 ddARGGRLTVVFG 382
Cdd:COG0770  349 --PGGGRRIAVLG 359
murF TIGR01143
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ...
 28-365 1.44e-26

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273468 [Multi-domain]  Cd Length: 417  Bit Score: 111.59  E-value: 1.44e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747   28 IDHRKVAPGTVFGAFRGERFNAEDVIPQAIEAGAVAVVASPE-ARVEGAAHVASEEPRRAFARLAARFFEPVPETLVAVT 106
Cdd:TIGR01143   1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREvGPDNGLPQILVDDTLEALQALARAKRAKFSGKVIGIT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  107 GTNGKTSTAEMTRQIWRMCGRSAASIGTLgvttpdgsvSTGLTTPdivTFLANMAGLAREGVTHVAyeASSHGLAQYRNE 186
Cdd:TIGR01143  81 GSSGKTTTKEMLAAILSHKYKVFATPGNF---------NNEIGLP---LTLLRAPGDHDYAVLEMG--ASHPGEIAYLAE 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  187 GLTLAASAFTNFSRDHLDYHGTMEAYFEAKMRLFdEVAQPASPAVIfdgGRDEVWIPKAIERAKARglDVRSVGEKGRFL 266
Cdd:TIGR01143 147 IAKPDIAVITNIGPAHLEGFGSLEGIAEAKGEIL-QGLKENGIAVI---NADDPAFADLAKRLPNR--NILSFGFEGGDF 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  267 RLTAREATQLGQV-LTVEFEGSARTIKLPLIGEYQAANALVAAGLALSTGCEAGQVFDALSRLQPVRGRLEraAIAPVGA 345
Cdd:TIGR01143 221 VAKDISYSALGSTsFTLVAPGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFE--VQTKNGL 298

                         330       340
                  ....*....|....*....|.
gi 736904747  346 PVYVD-YAHTPDAMEAAIAAL 365
Cdd:TIGR01143 299 TLIDDtYNANPDSMRAALDAL 319
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 103-425 1.65e-26

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 111.71  E-value: 1.65e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 103 VAVTGTNGKTSTAEMTRQIWRMCGRSAASIGTLGVTtpdgsvstglttpdIVTFLANMaglarEGVTHVAYEASSHGLAq 182
Cdd:COG0771  108 IAITGTNGKTTTTTLIGHILKAAGLRVAVGGNIGTP--------------LLDLLLEP-----EPPDVYVLELSSFQLE- 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 183 yRNEGLTLAASAFTNFSRDHLDYHGTMEAYFEAKMRLFDEvAQPASPAVIfdgGRDEVWIPKAIERAKAR--GLDVRSVG 260
Cdd:COG0771  168 -TTPSLRPDVAVILNITPDHLDRHGSMEAYAAAKARIFAN-QTPDDYAVL---NADDPLTRALAEEAKARvvPFSLKEPL 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 261 EKGRFLR---LTAREATQLgqVLTVEfegsartiKLPLIGEYQAANALVAAGLALSTGCEAGQVFDALSRLQPVRGRLEr 337
Cdd:COG0771  243 EGGAGLEdgkLVDRASGEE--LLPVD--------DLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLE- 311

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 338 aaiaPVGAPVYVDY-----AHTPDAMEAAIAALRGHvddarggrltVVFGAGGDrdpGKRAPMGDVAARGAERV--IVTd 410
Cdd:COG0771  312 ----FVAEINGVRFindskATNPDATLAALESFDGP----------VVLIAGGL---DKGADFSPLAPAVAERVkaVVL- 373

                        330
                 ....*....|....*
gi 736904747 411 dnpRGEDAGAIRAAI 425
Cdd:COG0771  374 ---IGEDAEKIAAAL 385
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 98-369 5.96e-24

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 103.96  E-value: 5.96e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747   98 VPETLVAVTGTNGKTSTAEMTRQIWRMCGRSAASIGTLGVttpdgsvstglttpdivtflANMAGLAREGVTHVAYEASS 177
Cdd:TIGR01087 100 VPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGNIGT--------------------PALEVLDQEGAELYVLELSS 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  178 HGLAqyRNEGLTLAASAFTNFSRDHLDYHGTMEAYFEAKMRLFDEVAQPaspavifdggrDEVWIPKAIERakARGLDVR 257
Cdd:TIGR01087 160 FQLE--TTESLRPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQTEG-----------DVAVLNADDPR--FARLAQK 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  258 SVGEKGRFlrlTAREATQLGqvltVEFEGSARTIK-----LPLIGEYQAANALVAAGLALSTGCEAGQVFDALSRLQPVR 332
Cdd:TIGR01087 225 SKAQVIWF---SVEKDAERG----LCIRDGGLYLKpndleGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLP 297

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 736904747  333 GRLEraAIAPVGAPVYVD--YAHTPDAMEAAIAALRGHV 369
Cdd:TIGR01087 298 HRLE--YVGQKNGVHFYNdsKATNVHATLAALSAFDNPV 334
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 15-465 8.51e-23

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 102.47  E-value: 8.51e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  15 AGEWSDAAVSGFAIDHRKVAPGTVFGAFRGERFNAEDVIPQAIEAGAVAVVASPEARVEGAAHVASEEPRRAFARLAARF 94
Cdd:PRK11929 518 LQINSLPHAGAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERQVADVDLPQIVVDDTRAALGRLATAW 597

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  95 FEPVPETLVAVTGTNGKTSTAEMTRQIWrmcgrsAASIGTLGVTTPDGSVSTGLTTPDIVTFLANM--AGLAREGVTHVA 172
Cdd:PRK11929 598 RARFSLPVVAITGSNGKTTTKEMIAAIL------AAWQGEDRVLATEGNFNNEIGVPLTLLRLRAQhrAAVFELGMNHPG 671

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 173 YEASSHGLAQyrnegltLAASAFTNFSRDHLDYHGTMEAYFEAKMRLFDevAQPASPAVIFDGgrDEVWIPKAIERAKAR 252
Cdd:PRK11929 672 EIAYLAAIAA-------PTVALVTNAQREHQEFMHSVEAVARAKGEIIA--ALPEDGVAVVNG--DDPYTAIWAKLAGAR 740

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 253 GLDVRSVGEKGRFLRLTAREATQLGQVLTVEFE-----GSARtIKLPLIGEYQAANALVAAGLALSTGCEAGQVFDALSR 327
Cdd:PRK11929 741 RVLRFGLQPGADVYAEKIAKDISVGEAGGTRCQvvtpaGSAE-VYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLER 819

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 328 LQPVRGRLERAAIApVGAPVYVD-YAHTPDAMEAAIAALrghVDDARGGRLTVV--FGAGGDRDPGKRAPMGDVAARGAE 404
Cdd:PRK11929 820 FQPVAGRMQRRRLS-CGTRIIDDtYNANPDSMRAAIDVL---AELPNGPRALVLgdMLELGDNGPAMHREVGKYARQLGI 895

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 736904747 405 RVIVTddnpRGEDAGAIRAAILEGARGAGgeaeiievAGRRDAIAEAIAGAGDHDIILVAG 465
Cdd:PRK11929 896 DALIT----LGEAARDAAAAFGAGARGVC--------ASVDEIIAALRGALPEGDSVLIKG 944
Mur_ligase_C pfam02875
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ...
 331-422 4.42e-22

Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460731 [Multi-domain]  Cd Length: 87  Bit Score: 90.10  E-value: 4.42e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  331 VRGRLERAAIAPvGAPVYVDYAHTPDAMEAAIAALRGHVDdargGRLTVVFGAGGDRDPGKRAPMGDVAARGAERVIVTD 410
Cdd:pfam02875   1 VPGRLEVVGENN-GVLVIDDYAHNPDAMEAALRALRNLFP----GRLILVFGGMGDRDAEFHALLGRLAAALADVVILTG 75

                          90
                  ....*....|..
gi 736904747  411 DNPRGEDAGAIR 422
Cdd:pfam02875  76 DYPRAEDPGAII 87
murF PRK10773
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
 3-335 6.03e-18

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed


Pssm-ID: 182718 [Multi-domain]  Cd Length: 453  Bit Score: 86.24  E-value: 6.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747   3 LSALLEAAGLEPAGEwsDAAVSGFAIDHRKVAPGTVFGAFRGERFNAEDVIPQAIEAGAVAVVASPEARVEgAAHVASEE 82
Cdd:PRK10773   6 LSQLADILNGELQGA--DITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPLDID-LPQLVVKD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  83 PRRAFARLAARFFEPVPETLVAVTGTNGKTSTAEMTRQIWRMCGRSAASIGTLgvtTPDGSVSTGL--TTPD----IVTF 156
Cdd:PRK10773  83 TRLAFGQLAAWVRQQVPARVVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNL---NNDIGVPLTLlrLTPEhdyaVIEL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 157 LANMAGlaregvtHVAYEASshglaqyrnegLTLAASAF-TNFSRDHLDYHGTMEAYFEAKMRLFDEVaqPASPAVIFDG 235
Cdd:PRK10773 160 GANHQG-------EIAYTVS-----------LTRPEAALvNNLAAAHLEGFGSLAGVAKAKGEIFSGL--PENGIAIMNA 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 236 ------------GRDEVW--IPKAIERAKARGLDVRSVGEKGRF-LRltareaTQLGQVltvefegsarTIKLPLIGEYQ 300
Cdd:PRK10773 220 dsndwlnwqsviGSKTVWrfSPNAANSVDFTATNIHVTSHGTEFtLH------TPTGSV----------DVLLPLPGRHN 283

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 736904747 301 AANALVAAGLALSTGCEAGQVFDALSRLQPVRGRL 335
Cdd:PRK10773 284 IANALAAAALAMSVGATLDAVKAGLANLKAVPGRL 318
MurC COG0773
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ...
 196-381 6.71e-18

UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440536 [Multi-domain]  Cd Length: 451  Bit Score: 85.89  E-value: 6.71e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 196 TNFSRDHLDYHGTMEAYFEAkmrlFDEVAQ--PASPAVIFDGGrDEVwIPKAIERAKARgldVRSVG-EKGRFLRLTARE 272
Cdd:COG0773  178 TNIEADHLDIYGDLEAIKEA----FHEFARnvPFYGLLVLCAD-DPG-LRELLPRCGRP---VITYGfSEDADYRAENIR 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 273 ATQLGQVLTVEFEG-SARTIKLPLIGEYQAANALVAAGLALSTGCEAGQVFDALSRLQPVRGRLERAAIAPvGAPVYVDY 351
Cdd:COG0773  249 IDGGGSTFDVLRRGeELGEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRFELKGEVG-GVTVIDDY 327

                        170       180       190
                 ....*....|....*....|....*....|
gi 736904747 352 AHTPDAMEAAIAALRGHVDDargGRLTVVF 381
Cdd:COG0773  328 AHHPTEIAATLAAAREKYPD---RRLVAVF 354
murC TIGR01082
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ...
 103-467 1.39e-15

UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273433 [Multi-domain]  Cd Length: 448  Bit Score: 78.89  E-value: 1.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  103 VAVTGTNGKTSTAEMTRQIWRMCGRSAASIgtLGVTTPDGSVSTGLTTPDIVTFLANmaglaregvthvayEASSHGLAq 182
Cdd:TIGR01082 102 IAVAGTHGKTTTTAMIAVILKEAGLDPTVV--VGGLVKEAGTNARLGSGEYLVAEAD--------------ESDASFLH- 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  183 yrnegLTLAASAFTNFSRDHLD-YHGTMEAYFEAkMRLFDEVAQPASPAVIF--DGGRDEVwIPKAIERAKARGLDvrsv 259
Cdd:TIGR01082 165 -----LQPNVAIVTNIEPDHLDtYGSSFERLKAA-FEKFIHNLPFYGLAVICadDPVLREL-VPKATEQVITYGGS---- 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  260 GEKGRFlRLTAREATQLGQVLTVE-FEGSARTIKLPLIGEYQAANALVAAGLALSTGCEAGQVFDALSRLQPVRGRLERA 338
Cdd:TIGR01082 234 GEDADY-RAENIQQSGAEGKFSVRgKGKLYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGVKRRFEIL 312

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  339 AIAPvGAPVYVDYAHTPDAMEAAIAALRGHVDDArggRLTVVFgaggdrDPGK----RAPMGDVAA--RGAERVIVTDDN 412
Cdd:TIGR01082 313 GEFG-GVLLIDDYAHHPTEIKATLKAARQGYPDK---RIVVVF------QPHRysrtRDLFDDFAKvlSDADELILLDIY 382

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 736904747  413 PRGED-AGAIRAAILEGARGAGGEAEIIEVAGRRDAIAEAIAGAGDHDIILVAGKG 467
Cdd:TIGR01082 383 AAGEEpINGIDGKSLARKITQLGKIEPYFVPDLAELVEFLAAVLQSGDLILTMGAG 438
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 103-367 1.35e-14

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 75.78  E-value: 1.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 103 VAVTGTNGKTSTAEMTRQIWRMCGRSAASIGTLGVTTPDGSVSTGlttPDivtflanmaglaregvTHVAYEASSHGLAQ 182
Cdd:PRK14106 111 VAITGTNGKTTTTTLLGEIFKNAGRKTLVAGNIGYPLIDAVEEYG---ED----------------DIIVAEVSSFQLET 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 183 YRNegLTLAASAFTNFSRDHLDYHGTMEAYFEAKMRLFdEVAQPASPAVI-FDGGRdevwIPKAIERAKARGL--DVRSV 259
Cdd:PRK14106 172 IKE--FKPKVGCILNITPDHLDRHKTMENYIKAKARIF-ENQRPSDYTVLnYDDPR----TRSLAKKAKARVIffSRKSL 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 260 GEKGRFLRltareatqlGQVLTVEFEGSARTI----KLPLIGEYQAANALVAAGLALSTGCEAGQVFDALSRLQPVRGRL 335
Cdd:PRK14106 245 LEEGVFVK---------NGKIVISLGGKEEEVididEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRI 315

                        250       260       270
                 ....*....|....*....|....*....|....
gi 736904747 336 EraAIAPVGAPVYV-DYAHT-PDAMEAAIAALRG 367
Cdd:PRK14106 316 E--FVAEINGVKFInDSKGTnPDAAIKALEAYET 347
PRK14093 PRK14093
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ...
 3-380 8.84e-10

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional


Pssm-ID: 184501 [Multi-domain]  Cd Length: 479  Bit Score: 60.94  E-value: 8.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747   3 LSALLEAAGLEPAGEWSDAaVSGFAIDHRKVAPGTVFGAFRGERFNAEDVIPQAIEAGA-VAVVASPEAR--VEGAAHVA 79
Cdd:PRK14093   9 SDAMAEAMGATRSGALPRD-VTGISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAaLAVVERAQRDkfAADAPLLV 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  80 SEEPRRAFARLAARFFEPVPETLVAVTGTNGKTSTAEMTRQIWRMCGRSAASIGTL----GVTTPdgsvstglttpdivt 155
Cdd:PRK14093  88 VDDVLAALRDLGRAARARLEAKVIAVTGSVGKTSTKEALRGVLGAQGETHASVASFnnhwGVPLS--------------- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 156 fLANMAGLAREGVTHVAYEASshGLAQYRNEGLTLAASAFTNFSRDHLDYHGTMEAYFEAKMRLFDEVaQPASPAVIfdg 235
Cdd:PRK14093 153 -LARCPADARFAVFEIGMNHA--GEIEPLVKMVRPHVAIITTVEPVHLEFFSGIEAIADAKAEIFTGL-EPGGAAVL--- 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 236 GRDEVWIPKAIERAKARGL-DVRSVGEKGRF-LRLTAREATQLGQVLTVEFEGSARTIKLPLIGEYQAANALVAAGLALS 313
Cdd:PRK14093 226 NRDNPQFDRLAASARAAGIaRIVSFGADEKAdARLLDVALHADCSAVHADILGHDVTYKLGMPGRHIAMNSLAVLAAAEL 305

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 314 TGCEAGQVFDALSRLQPVRGRLERAAIA-PVGAPVYVD--YAHTPDAMEAAIAALRGHVDDARGGRLTVV 380
Cdd:PRK14093 306 AGADLALAALALSQVQPAAGRGVRHTLEvGGGEATLIDesYNANPASMAAALGVLGRAPVGPQGRRIAVL 375
PRK14573 PRK14573
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
291-418 1.01e-07

bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;


Pssm-ID: 184752 [Multi-domain]  Cd Length: 809  Bit Score: 54.82  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 291 IKLPLIGEYQAANALVAAGLALSTGCEAGQVFDALSRLQPVRGRLERAAIAPVGApVYVDYAHTPDAMEAAIAALRghvd 370
Cdd:PRK14573 263 IELNLVGMHNVANAAAAMGIALTLGIDEGAIRNALKGFSGVQRRLERKNSSETFL-FLEDYAHHPSEISCTLRAVR---- 337

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 736904747 371 DARGGRlTVVFGAGGDRDPGKRAPMGDV--AARGAERVIVTDDNPRGEDA 418
Cdd:PRK14573 338 DAVGLR-RIIAICQPHRFSRLRECLDSFpsAFQDADEVILTDVYSAGEEP 386
PRK11930 PRK11930
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ...
 20-336 2.17e-07

putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional


Pssm-ID: 237026 [Multi-domain]  Cd Length: 822  Bit Score: 53.81  E-value: 2.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  20 DAAVSGFAIDHRKV--APGTVFGAFRGERFNAEDVIPQAIEAGA-VAVVASPEARVE---GAAHVASEEPRRAFARLAAR 93
Cdd:PRK11930  21 DAIIDQILTDSRSLsfPENTLFFALKGERNDGHRYIQELYEKGVrNFVVSEEKHPEEsypDANFLKVKDPLKALQELAAY 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747  94 FFEPVPETLVAVTGTNGKTSTAEMTRQI----WRMCgRSAAS----IG------------TLGVttpdgsVSTGLTTPDI 153
Cdd:PRK11930 101 HRSQFDIPVIGITGSNGKTIVKEWLYQLlspdYNIV-RSPRSynsqIGvplsvwqlneehELGI------FEAGISQPGE 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 154 VTFLANMAglaregvthvayeASSHGLaqyrnegltlaasaFTNFSRDHLDYHGTMEAYFEAKMRLFDevaqpASPAVIF 233
Cdd:PRK11930 174 MEALQKII-------------KPTIGI--------------LTNIGGAHQENFRSIKQKIMEKLKLFK-----DCDVIIY 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747 234 DGGRDEVWIPKAIERAKARGLDvRSVGEKGRFLRLTAREATQLGQVLTVEFEGSARTIKLPLIGEYQAANALVAAGLALS 313
Cdd:PRK11930 222 NGDNELISSCITKSNLTLKLIS-WSRKDPEAPLYIPFVEKKEDHTVISYTYKGEDFHFEIPFIDDASIENLIHCIAVLLY 300

                        330       340
                 ....*....|....*....|...
gi 736904747 314 TGCEAGQVFDALSRLQPVRGRLE 336
Cdd:PRK11930 301 LGYSADQIQERMARLEPVAMRLE 323
Mur_ligase pfam01225
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ...
 23-82 2.07e-04

Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460121 [Multi-domain]  Cd Length: 84  Bit Score: 39.91  E-value: 2.07e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 736904747   23 VSGFAIDHRKVAPGTVFGAFRGERFNAEDVIPQAIEAGAVAVVASPEARVEGAAHVASEE 82
Cdd:pfam01225   2 IHFVGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGHDAANNISPDNPELEA 61
PRK14016 PRK14016
cyanophycin synthetase; Provisional
 102-142 2.42e-04

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 43.61  E-value: 2.42e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 736904747 102 LVAVTGTNGKTSTAEMTRQIWRMCGRsaasigTLGVTTPDG 142
Cdd:PRK14016 482 IVAVTGTNGKTTTTRLIAHILKLSGK------RVGMTTTDG 516
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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