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Conserved domains on  [gi|737222677|ref|WP_035207339|]
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GntR family transcriptional regulator [Agrobacterium pusense]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
2-216 2.33e-45

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 150.46  E-value: 2.33e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222677   2 TETIEGLPLADRLAKGIRTLLISGELAPGQRLSEAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFVAVPTISSVI 81
Cdd:COG1802    4 PSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222677  82 DIYRVRRMVECGALRQAWHKHPA--IKTMRAAVEDAKVKREAADWLGVGSANMKFHAAVVDLLDSARISDFYERIAAELR 159
Cdd:COG1802   84 ELYEVRAALEGLAARLAAERATPadLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLR 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 737222677 160 LCFGLLKDPEQLHSPFVDMNSKILSLMEEGKAQEAGDEMDTYLNLSERTVLKALERA 216
Cdd:COG1802  164 RYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAA 220
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
2-216 2.33e-45

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 150.46  E-value: 2.33e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222677   2 TETIEGLPLADRLAKGIRTLLISGELAPGQRLSEAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFVAVPTISSVI 81
Cdd:COG1802    4 PSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222677  82 DIYRVRRMVECGALRQAWHKHPA--IKTMRAAVEDAKVKREAADWLGVGSANMKFHAAVVDLLDSARISDFYERIAAELR 159
Cdd:COG1802   84 ELYEVRAALEGLAARLAAERATPadLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLR 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 737222677 160 LCFGLLKDPEQLHSPFVDMNSKILSLMEEGKAQEAGDEMDTYLNLSERTVLKALERA 216
Cdd:COG1802  164 RYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAA 220
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 9-73 8.23e-17

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 71.71  E-value: 8.23e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 737222677   9 PLADRLAKGIRTLLISGELAPGQRL-SEAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFVA 73
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 10-72 1.26e-11

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 58.01  E-value: 1.26e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 737222677   10 LADRLAKGIRTLLISGELAPGQRL-SEAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFV 72
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
18-72 1.45e-10

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 54.89  E-value: 1.45e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 737222677    18 IRTLLISGELAPGQRL-SEAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFV 72
Cdd:smart00345   5 LREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 8-138 3.68e-08

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 52.08  E-value: 3.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222677   8 LPLADRLAKGIRTLLISGELAPGQRL-SEAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFVA-----------VP 75
Cdd:PRK10421   1 RRLSDEVADRVRALIEEKNLEAGMKLpAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRwrhetwseqniVQ 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 737222677  76 TISSVI--------DIYRVRRMVECGAlrqAWHkhpaiKTMRAAVED-AKVKR-----EAADWLGVGSANMKFHAAV 138
Cdd:PRK10421  81 PLKTLMaddpdysfDILEARHAIEAST---AWH-----AAMRATPGDkEKIQLcfeatLSEDPDLASQADVRFHLAI 149
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
2-216 2.33e-45

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 150.46  E-value: 2.33e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222677   2 TETIEGLPLADRLAKGIRTLLISGELAPGQRLSEAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFVAVPTISSVI 81
Cdd:COG1802    4 PSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222677  82 DIYRVRRMVECGALRQAWHKHPA--IKTMRAAVEDAKVKREAADWLGVGSANMKFHAAVVDLLDSARISDFYERIAAELR 159
Cdd:COG1802   84 ELYEVRAALEGLAARLAAERATPadLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLR 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 737222677 160 LCFGLLKDPEQLHSPFVDMNSKILSLMEEGKAQEAGDEMDTYLNLSERTVLKALERA 216
Cdd:COG1802  164 RYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAA 220
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
3-216 1.49e-23

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 94.23  E-value: 1.49e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222677   3 ETIEGLPLADRLAKGIRTLLISGELAPGQRL-SEAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFVAVPTIS--- 78
Cdd:COG2186    1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLpSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWall 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222677  79 ------------SVIDIYRVRRMVECGALRQAWHKHPA--IKTMRAAVEDAkvKREAADWLGVGSANMKFHAAVVDLLDS 144
Cdd:COG2186   81 dplalllalddaSLRDLLEARLALEPEAARLAAERATDedLARLEAALAEM--EAAADDGEAFAEADLAFHRAIAEASGN 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 737222677 145 ARISDFYERIAAELRLCFGLLKDPEQLHSPFVDMNSKILSLMEEGKAQEAGDEMDTYLNLSERTVLKALERA 216
Cdd:COG2186  159 PLLALLLESLRELLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALAER 230
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 9-73 8.23e-17

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 71.71  E-value: 8.23e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 737222677   9 PLADRLAKGIRTLLISGELAPGQRL-SEAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFVA 73
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
7-127 2.79e-13

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 66.42  E-value: 2.79e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222677   7 GLPLADRLAKGIRTLLISGELAPGQRL-SEAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFVAVPTISSviDIYR 85
Cdd:COG2188    3 PVPLYLQIADALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEY--PLSR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 737222677  86 VRRMVEcgALRQAwHKHPAIKTMRAAVEDAkvKREAADWLGV 127
Cdd:COG2188   81 LTSFTE--ELRAR-GREPSTRVLSAERVPA--DEEVAEALGL 117
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 10-72 1.26e-11

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 58.01  E-value: 1.26e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 737222677   10 LADRLAKGIRTLLISGELAPGQRL-SEAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFV 72
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
18-72 1.45e-10

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 54.89  E-value: 1.45e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 737222677    18 IRTLLISGELAPGQRL-SEAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFV 72
Cdd:smart00345   5 LREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 7-73 8.79e-09

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 54.83  E-value: 8.79e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 737222677   7 GLPLADRLAKGIRTLLISGELAPGQRL-SEAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFVA 73
Cdd:COG1167   10 SGPLYLQLADALREAILSGRLPPGDRLpSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVA 77
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 8-138 3.68e-08

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 52.08  E-value: 3.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222677   8 LPLADRLAKGIRTLLISGELAPGQRL-SEAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFVA-----------VP 75
Cdd:PRK10421   1 RRLSDEVADRVRALIEEKNLEAGMKLpAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRwrhetwseqniVQ 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 737222677  76 TISSVI--------DIYRVRRMVECGAlrqAWHkhpaiKTMRAAVED-AKVKR-----EAADWLGVGSANMKFHAAV 138
Cdd:PRK10421  81 PLKTLMaddpdysfDILEARHAIEAST---AWH-----AAMRATPGDkEKIQLcfeatLSEDPDLASQADVRFHLAI 149
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 82-198 4.89e-08

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 49.68  E-value: 4.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222677   82 DIYRVRRMVECGALRQAWHKHPA--IKTMRAAVEDAKVKREAADWLGVGSANMKFHAAVVDLLDSARISDFYERIAAELR 159
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDedLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 737222677  160 LCFGLLKDPEQLHSPFVDMNSKILSLMEEGKAQEAGDEM 198
Cdd:pfam07729  81 RLRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAM 119
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 82-203 2.96e-07

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 47.74  E-value: 2.96e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222677    82 DIYRVRRMVECGALRQAWHKHPA--IKTMRAAVEDAKVKREAADWL-GVGSANMKFHAAVVDLLDSARISDFYERIAAEL 158
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDedLAALEALLDAMEAAAAAGDDLeEFAELDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 737222677   159 RLcfgLLKDPEQLHSPFVDMNSKILSLMEEGKAQEAGDEMDTYLN 203
Cdd:smart00895  81 RR---LRRLSLEAARRALDEHRAILDAIRARDAEAARAAMREHLE 122
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 9-98 3.10e-07

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 49.38  E-value: 3.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222677   9 PLADRLAKGIRTLLISGELAPGQRL-SEAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFVA----VPTISSVI-- 81
Cdd:PRK09990   7 PIADVVAERIERLIVDGVLKVGQALpSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVArlnrVQDASPLMhl 86

                         90       100
                 ....*....|....*....|....*.
gi 737222677  82 ---------DIYRVRRMVECGALRQA 98
Cdd:PRK09990  87 fssqprtlyDLLEVRALLEGESARLA 112
PRK09764 PRK09764
GntR family transcriptional regulator;
8-98 3.18e-05

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 43.66  E-value: 3.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222677   8 LPLADRLAKGIRTLLISGELAPGQRL-SEAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFVAVPTISsvIDIYRV 86
Cdd:PRK09764   4 KPLYRQIADRIREQIARGELKPGDALpTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVN--YDIFQL 81

                         90
                 ....*....|..
gi 737222677  87 RRMVECGALRQA 98
Cdd:PRK09764  82 TSFDEKLSDRHV 93
PRK14999 PRK14999
histidine utilization repressor; Provisional
 9-139 4.32e-05

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 43.00  E-value: 4.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222677   9 PLADRLAKGIRTLLISGELAPGQRL-SEAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFVAVPTISSVidIYRVR 87
Cdd:PRK14999  12 PFYETVKQDICKKIAGGVWQPHDRIpSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSA--LFEVR 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 737222677  88 RMVECGALRQAWHKHPAIktmraAVEDAKVKREAADWLGVGSANMKFHAAVV 139
Cdd:PRK14999  90 SIAEEIAARRHQHRCEVL-----TLERVRANAIQASALNVNESDVIFHSIMV 136
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
10-72 4.52e-05

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 43.09  E-value: 4.52e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 737222677  10 LADRLAKGIRTLLISGELAPGQRL-SEAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFV 72
Cdd:PRK09464  11 LSDVIEQQLEFLILEGTLRPGEKLpPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFV 74
PRK10225 PRK10225
Uxu operon transcriptional regulator;
18-153 2.85e-04

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 40.77  E-value: 2.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737222677  18 IRTLLISGELAPGQRLS-EAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFVAVPTISSVID-------------- 82
Cdd:PRK10225  18 IRDLIIKTPYNPGERLPpEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNTDspdanvcndagpfe 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 737222677  83 IYRVRRMVECG----ALRQAWHKHpaIKTMRAA--VEDAKVKREAADwlGVGSANMKFHAAVVDLLDSARISDFYER 153
Cdd:PRK10225  98 LLQARQLLESNiaefAALQATRED--IVKMRQAlqLEERELASSAPG--SSESGDMQFHLAIAEATHNSMLVELFRQ 170
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 12-63 1.11e-03

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 38.85  E-value: 1.11e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 737222677  12 DRLAKGIRtlliSGELAPGQRL-SEAAFSERFDVSRNSLREAFRLLTKDGLLR 63
Cdd:PRK03837  20 ERLEQMIR----SGEFGPGDQLpSERELMAFFGVGRPAVREALQALKRKGLVQ 68
PRK11402 PRK11402
transcriptional regulator PhoB;
10-75 2.82e-03

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 37.89  E-value: 2.82e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 737222677  10 LADRLAKGIRTllisgelaPGQRL-SEAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFVAVP 75
Cdd:PRK11402  18 LLDDIAQGVYQ--------AGQQIpTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQ 76
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 22-98 8.69e-03

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 36.03  E-value: 8.69e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 737222677  22 LISGELAPGQRLSEAAFSERFDVSRNSLREAFRLLTKDGLLRHEANRGVFVAVPTISSVIDIYRVRRMVECGALRQA 98
Cdd:PRK11534  20 IIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMEAMLVSLA 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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