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Conserved domains on  [gi|737226329|ref|WP_035210707|]
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MULTISPECIES: peptide chain release factor 1 [Agrobacterium]

Protein Classification

peptide chain release factor 1( domain architecture ID 11415460)

peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA

Gene Ontology:  GO:0016149

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 7-356 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


:

Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 655.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329   7 EKMRELERRFGEIEARMSAgPAA----DVYVKLASEYSELEPVVKKIREYEKAISEAADLEALLADKStDKDMRELAEME 82
Cdd:COG0216    4 DKLEALEERYEELEALLSD-PEVisdqKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEES-DPEMREMAKEE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329  83 LPEIESRIEELEKDMQVLLLPKDAADEKSAILEIRAGTGGSEAALFAGDLFRMYERFAASKGWKVEVLSASEGEAGGYKE 162
Cdd:COG0216   82 LEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329 163 IIATISGRGVFSKLKFESGVHRVQRVPETEASGRIHTSAATVAVLPEAEEIDIEIRPEDIRIDTMRASGAGGQHVNTTDS 242
Cdd:COG0216  162 VIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329 243 AVRITHLPTGLIVTS-SEKSQHQNRAKAMQVLRSRLYDIERQKVDSERSADRKSQVGSGDRSERIRTYNFPQGRVTDHRI 321
Cdd:COG0216  242 AVRITHLPTGIVVECqDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 737226329 322 NLTLYKLDRMIEGEIDELVDALIADYQAGQLAQLG 356
Cdd:COG0216  322 NLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 7-356 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 655.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329   7 EKMRELERRFGEIEARMSAgPAA----DVYVKLASEYSELEPVVKKIREYEKAISEAADLEALLADKStDKDMRELAEME 82
Cdd:COG0216    4 DKLEALEERYEELEALLSD-PEVisdqKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEES-DPEMREMAKEE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329  83 LPEIESRIEELEKDMQVLLLPKDAADEKSAILEIRAGTGGSEAALFAGDLFRMYERFAASKGWKVEVLSASEGEAGGYKE 162
Cdd:COG0216   82 LEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329 163 IIATISGRGVFSKLKFESGVHRVQRVPETEASGRIHTSAATVAVLPEAEEIDIEIRPEDIRIDTMRASGAGGQHVNTTDS 242
Cdd:COG0216  162 VIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329 243 AVRITHLPTGLIVTS-SEKSQHQNRAKAMQVLRSRLYDIERQKVDSERSADRKSQVGSGDRSERIRTYNFPQGRVTDHRI 321
Cdd:COG0216  242 AVRITHLPTGIVVECqDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 737226329 322 NLTLYKLDRMIEGEIDELVDALIADYQAGQLAQLG 356
Cdd:COG0216  322 NLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
prfA PRK00591
peptide chain release factor 1; Validated
 3-357 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 650.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329   3 KLPVEKMRELERRFGEIEARMSAGPAA---DVYVKLASEYSELEPVVKKIREYEKAISEAADLEALLADKStDKDMRELA 79
Cdd:PRK00591   2 PSMLDKLEALEERYEELEALLSDPEVIsdqKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEES-DPEMREMA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329  80 EMELPEIESRIEELEKDMQVLLLPKDAADEKSAILEIRAGTGGSEAALFAGDLFRMYERFAASKGWKVEVLSASEGEAGG 159
Cdd:PRK00591  81 KEELKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329 160 YKEIIATISGRGVFSKLKFESGVHRVQRVPETEASGRIHTSAATVAVLPEAEEIDIEIRPEDIRIDTMRASGAGGQHVNT 239
Cdd:PRK00591 161 YKEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329 240 TDSAVRITHLPTGLIVT-SSEKSQHQNRAKAMQVLRSRLYDIERQKVDSERSADRKSQVGSGDRSERIRTYNFPQGRVTD 318
Cdd:PRK00591 241 TDSAVRITHLPTGIVVEcQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTD 320

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 737226329 319 HRINLTLYKLDRMIEGEIDELVDALIADYQAGQLAQLGE 357
Cdd:PRK00591 321 HRINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALGE 359
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 1-358 0e+00

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 513.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329    1 MAKLPVEKMRELERRFGEIEARMSAGPAA---DVYVKLASEYSELEPVVKKIREYEKAISEAADLEALLadKSTDKDMRE 77
Cdd:TIGR00019   1 MKPSLLEKLESLLERYEELEALLSDPEVIsdqDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEIL--EESDPEMRE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329   78 LAEMELPEIESRIEELEKDMQVLLLPKDAADEKSAILEIRAGTGGSEAALFAGDLFRMYERFAASKGWKVEVLSASEGEA 157
Cdd:TIGR00019  79 MAKEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETEL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329  158 GGYKEIIATISGRGVFSKLKFESGVHRVQRVPETEASGRIHTSAATVAVLPEAEEIDIEIRPEDIRIDTMRASGAGGQHV 237
Cdd:TIGR00019 159 GGYKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQHV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329  238 NTTDSAVRITHLPTGLIVT-SSEKSQHQNRAKAMQVLRSRLYDIERQKVDSERSADRKSQVGSGDRSERIRTYNFPQGRV 316
Cdd:TIGR00019 239 NTTDSAVRITHLPTGIVVEcQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRV 318

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 737226329  317 TDHRINLTLYKLDRMIEGEIDELVDALIADYQAGQLAQLGEQ 358
Cdd:TIGR00019 319 TDHRINLTLYKLDEVLEGDLDELIEALIAEDQAQQLAALSEE 360
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 12-204 2.34e-101

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 296.99  E-value: 2.34e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329   12 LERRFGEIEARMSAGPA---ADVYVKLASEYSELEPVVKKIREYEKAISEAADLEALLADKstdkDMRELAEMELPEIES 88
Cdd:pfam03462   1 LEERYEELEALLSDPDVwddQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLEDP----ELAELAEEELEELEK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329   89 RIEELEKDMQVLLLPKDAADEKSAILEIRAGTGGSEAALFAGDLFRMYERFAASKGWKVEVLSASEGEAGGYKEIIATIS 168
Cdd:pfam03462  77 RLEELEEELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEIS 156

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 737226329  169 GRGVFSKLKFESGVHRVQRVPETEASGRIHTSAATV 204
Cdd:pfam03462 157 GEGAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
PCRF smart00937
This domain is found in peptide chain release factors;
66-179 1.09e-52

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 169.95  E-value: 1.09e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329    66 LADKSTDKDMRELAEMELPEIE-SRIEELEKDMQVLLLPKDAADEKSAILEIRAGTGGSEAALFAGDLFRMYERFAASKG 144
Cdd:smart00937   2 LLEEEEDDEMRELAEEELEELEaELEEELEELLKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERKG 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 737226329   145 WKVEVLSASEGEAGGYKEIIATISGRGVFSKLKFE 179
Cdd:smart00937  82 WKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 7-356 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 655.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329   7 EKMRELERRFGEIEARMSAgPAA----DVYVKLASEYSELEPVVKKIREYEKAISEAADLEALLADKStDKDMRELAEME 82
Cdd:COG0216    4 DKLEALEERYEELEALLSD-PEVisdqKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEES-DPEMREMAKEE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329  83 LPEIESRIEELEKDMQVLLLPKDAADEKSAILEIRAGTGGSEAALFAGDLFRMYERFAASKGWKVEVLSASEGEAGGYKE 162
Cdd:COG0216   82 LEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329 163 IIATISGRGVFSKLKFESGVHRVQRVPETEASGRIHTSAATVAVLPEAEEIDIEIRPEDIRIDTMRASGAGGQHVNTTDS 242
Cdd:COG0216  162 VIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329 243 AVRITHLPTGLIVTS-SEKSQHQNRAKAMQVLRSRLYDIERQKVDSERSADRKSQVGSGDRSERIRTYNFPQGRVTDHRI 321
Cdd:COG0216  242 AVRITHLPTGIVVECqDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 737226329 322 NLTLYKLDRMIEGEIDELVDALIADYQAGQLAQLG 356
Cdd:COG0216  322 NLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
prfA PRK00591
peptide chain release factor 1; Validated
 3-357 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 650.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329   3 KLPVEKMRELERRFGEIEARMSAGPAA---DVYVKLASEYSELEPVVKKIREYEKAISEAADLEALLADKStDKDMRELA 79
Cdd:PRK00591   2 PSMLDKLEALEERYEELEALLSDPEVIsdqKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEES-DPEMREMA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329  80 EMELPEIESRIEELEKDMQVLLLPKDAADEKSAILEIRAGTGGSEAALFAGDLFRMYERFAASKGWKVEVLSASEGEAGG 159
Cdd:PRK00591  81 KEELKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329 160 YKEIIATISGRGVFSKLKFESGVHRVQRVPETEASGRIHTSAATVAVLPEAEEIDIEIRPEDIRIDTMRASGAGGQHVNT 239
Cdd:PRK00591 161 YKEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329 240 TDSAVRITHLPTGLIVT-SSEKSQHQNRAKAMQVLRSRLYDIERQKVDSERSADRKSQVGSGDRSERIRTYNFPQGRVTD 318
Cdd:PRK00591 241 TDSAVRITHLPTGIVVEcQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTD 320

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 737226329 319 HRINLTLYKLDRMIEGEIDELVDALIADYQAGQLAQLGE 357
Cdd:PRK00591 321 HRINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALGE 359
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 1-358 0e+00

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 513.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329    1 MAKLPVEKMRELERRFGEIEARMSAGPAA---DVYVKLASEYSELEPVVKKIREYEKAISEAADLEALLadKSTDKDMRE 77
Cdd:TIGR00019   1 MKPSLLEKLESLLERYEELEALLSDPEVIsdqDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEIL--EESDPEMRE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329   78 LAEMELPEIESRIEELEKDMQVLLLPKDAADEKSAILEIRAGTGGSEAALFAGDLFRMYERFAASKGWKVEVLSASEGEA 157
Cdd:TIGR00019  79 MAKEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETEL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329  158 GGYKEIIATISGRGVFSKLKFESGVHRVQRVPETEASGRIHTSAATVAVLPEAEEIDIEIRPEDIRIDTMRASGAGGQHV 237
Cdd:TIGR00019 159 GGYKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQHV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329  238 NTTDSAVRITHLPTGLIVT-SSEKSQHQNRAKAMQVLRSRLYDIERQKVDSERSADRKSQVGSGDRSERIRTYNFPQGRV 316
Cdd:TIGR00019 239 NTTDSAVRITHLPTGIVVEcQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRV 318

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 737226329  317 TDHRINLTLYKLDRMIEGEIDELVDALIADYQAGQLAQLGEQ 358
Cdd:TIGR00019 319 TDHRINLTLYKLDEVLEGDLDELIEALIAEDQAQQLAALSEE 360
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 12-204 2.34e-101

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 296.99  E-value: 2.34e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329   12 LERRFGEIEARMSAGPA---ADVYVKLASEYSELEPVVKKIREYEKAISEAADLEALLADKstdkDMRELAEMELPEIES 88
Cdd:pfam03462   1 LEERYEELEALLSDPDVwddQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLEDP----ELAELAEEELEELEK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329   89 RIEELEKDMQVLLLPKDAADEKSAILEIRAGTGGSEAALFAGDLFRMYERFAASKGWKVEVLSASEGEAGGYKEIIATIS 168
Cdd:pfam03462  77 RLEELEEELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEIS 156

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 737226329  169 GRGVFSKLKFESGVHRVQRVPETEASGRIHTSAATV 204
Cdd:pfam03462 157 GEGAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 11-344 2.61e-86

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 265.10  E-value: 2.61e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329   11 ELERRFGEIEARMSAGPAADVYVK---LASEYSELEPVVKKIREYEKAISEAADLEALLADKStDKDMRELAEMELPEIE 87
Cdd:TIGR00020  27 KKKARLEELEKEMEDPNFWNDQERaqaVIKERSSLEAVLDTLEELKNSLEDLSELLELAVEED-DEETFNELDAELKALE 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329   88 SRIEELEkdmqVLLLPKDAADEKSAILEIRAGTGGSEAALFAGDLFRMYERFAASKGWKVEVLSASEGEAGGYKEIIATI 167
Cdd:TIGR00020 106 KKLAELE----LRTMLSGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFKVEIIDYSEGEEAGIKSVTILI 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329  168 SGRGVFSKLKFESGVHRVQRVPETEASGRIHTSAATVAVLPEA-EEIDIEIRPEDIRIDTMRASGAGGQHVNTTDSAVRI 246
Cdd:TIGR00020 182 KGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVdDDIDIEIKPEDLRIDTYRASGAGGQHVNKTDSAVRI 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329  247 THLPTGLIVTS-SEKSQHQNRAKAMQVLRSRLYDIERQKVDSERSA--DRKSQVGSGDrseRIRTYNF-PQGRVTDHRIN 322
Cdd:TIGR00020 262 THIPTGIVVQCqNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAkeGEKSEIGWGS---QIRSYVLhPYSMVKDLRTG 338

                         330       340
                  ....*....|....*....|..
gi 737226329  323 LTLYKLDRMIEGEIDELVDALI 344
Cdd:TIGR00020 339 YETGNVQAVLDGDIDQFIEAYL 360
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 42-350 8.50e-67

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 213.37  E-value: 8.50e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329  42 LEPVVKKIREYEKAISEAADLEALlADKSTDKDMRELAEMELPEIESRIEELEkdMQVLLLPKdaADEKSAILEIRAGTG 121
Cdd:PRK08787   2 LEKTVIGIADVLSGLADAGELLDL-AESEQDEDTALAVIADLDKYQAHVEKLE--FQRMFSGQ--MDGANAFVDIQAGAG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329 122 GSEAALFAGDLFRMYERFAASKGWKVEVLSASEGEAGGYKEIIATISGRGVFSKLKFESGVHRVQRVPETEASGRIHTSA 201
Cdd:PRK08787  77 GTEAQDWAEILLRMYLRWAESRGWKTELMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTSF 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329 202 ATVAVLPEAEE-IDIEIRPEDIRIDTMRASGAGGQHVNTTDSAVRITHLPTGLIVT-SSEKSQHQNRAKAMQVLRSRLYD 279
Cdd:PRK08787 157 TSVFVSPEVDDnIEIDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVAcQTGRSQHQNRDNAMKMLAAKLYE 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 737226329 280 IERQKVDSERSA--DRKSQVGSGdrsERIRTYNFPQGRVTDHRINLTLYKLDRMIEGEIDELVDA-LIADYQAG 350
Cdd:PRK08787 237 LEVQKRNAEKDAleATKSDIGWG---SQIRNYVLDQSRIKDLRTGIERSDTQKVLDGDLDEFVEAsLKAGLAAG 307
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 33-342 1.61e-64

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 207.74  E-value: 1.61e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329  33 VKLASEYSELEPVVK-KIREYEKAISEAADLEALLA-DKSTDKDMRELAEMELPEIESRIEELEkdMQVLLlpKDAADEK 110
Cdd:PRK05589  10 IKEAQEITSEEKYLKdKLDKYNHLRNRIEDIEVLCEmMSEEDDEMKKEIISEVKNIKEEIDRFK--IETLL--SGEYDRN 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329 111 SAILEIRAGTGGSEAALFAGDLFRMYERFAASKGWKVEVLSASEGEAGGYKEIIATISGRGVFSKLKFESGVHRVQRVPE 190
Cdd:PRK05589  86 NAILTLHSGVGGTDAQDWTEMLLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEKGIHRLVRISP 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329 191 TEASGRIHTSAATVAVLPE-AEEIDIEIRPEDIRIDTMRASGAGGQHVNTTDSAVRITHLPTGLIVTS-SEKSQHQNRAK 268
Cdd:PRK05589 166 FNANGKRQTSFASVEVLPElTDDQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCqNERSQHSNKET 245

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 737226329 269 AMQVLRSRLYDIeRQKVDSERSADRKSQVGSGDRSERIRTYNF-PQGRVTDHRINLTLYKLDRMIEGEIDELVDA 342
Cdd:PRK05589 246 AMKMLKSKLVEL-KERAHKEKIEDLTGELKDMGWGSQIRSYVFhPYNLVKDHRTGVETSNVDSVMDGDIDNFITQ 319
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 34-345 3.02e-63

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 205.11  E-value: 3.02e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329  34 KLASEYSELEPVVKKIREYEKAISEAADLEALlADKSTDKDMRELAEMELPEIESRIEElekdMQVLLLPKDAADEKSAI 113
Cdd:PRK07342  17 KLMRERQQLDDSINGINHLEQTLNDNIELIAM-GEEEGDKSIVEDAEKTIRDLKDEIDR----RQIDALLSGEADANDTY 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329 114 LEIRAGTGGSEAALFAGDLFRMYERFAASKGWKVEVLSASEGEAGGYKEIIATISGRGVFSKLKFESGVHRVQRVPETEA 193
Cdd:PRK07342  92 LEVHAGAGGTESQDWASMLLRMYTRWAERQGRKVEVLEVHDGEEAGIKSATILVKGHNAYGWLKTESGVHRLVRISPYDS 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329 194 SGRIHTSAATVAVLPEAEE-IDIEIRPEDIRIDTMRASGAGGQHVNTTDSAVRITHLPTGLIVT-SSEKSQHQNRAKAMQ 271
Cdd:PRK07342 172 NARRHTSFASIWVYPVIDDnIEVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQcQQERSQHKNRAKAWS 251

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 737226329 272 VLRSRLYDIERQKVDSERSADR--KSQVGSGdrsERIRTYNF-PQGRVTDHRINLTLYKLDRMIEGEIDELVDALIA 345
Cdd:PRK07342 252 MLRARLYEEELKKREEATNAAAasKTDIGWG---HQIRSYVLqPYQLVKDLRTGVESTNPQDVLDGDLNEFMEAALA 325
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 211-320 4.13e-62

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 194.18  E-value: 4.13e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329  211 EEIDIEIRPEDIRIDTMRASGAGGQHVNTTDSAVRITHLPTGLIVTSS-EKSQHQNRAKAMQVLRSRLYDIERQKVDsER 289
Cdd:pfam00472   1 DEIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQdERSQHQNREKALKRLRARLYELEEEKEE-EK 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 737226329  290 SADRKSQVGSGDRSERIRTYNF-PQGRVTDHR 320
Cdd:pfam00472  80 KRRIKSQVGSGDRSEQIRTYNFkPQSRVKDHR 111
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 37-344 1.37e-61

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 200.34  E-value: 1.37e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329  37 SEYSELEPVVKKIREYEKAIsEAADLEALLADKSTDKDMRElaEMElPEIESRIEEL-EKDMQVLLlpKDAADEKSAILE 115
Cdd:PRK06746  18 NEANALKDMVGKFRQLDETF-ENLEITHELLKEEYDEDLHE--ELE-SEVKGLIQEMnEYELQLLL--SDPYDKNNAILE 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329 116 IRAGTGGSEAALFAGDLFRMYERFAASKGWKVEVLSASEGEAGGYKEIIATISGRGVFSKLKFESGVHRVQRVPETEASG 195
Cdd:PRK06746  92 LHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSG 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329 196 RIHTSAATVAVLPE-AEEIDIEIRPEDIRIDTMRASGAGGQHVNTTDSAVRITHLPTGLIVT-SSEKSQHQNRAKAMQVL 273
Cdd:PRK06746 172 RRHTSFVSCEVVPEfNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTcQSERSQIKNREHAMKML 251

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 737226329 274 RSRLYD--IERQKVDSERSADRKSQVGSGdrsERIRTYNF-PQGRVTDHRINLTLYKLDRMIEGEIDELVDALI 344
Cdd:PRK06746 252 KAKLYQkkLEEQQAELDEIRGEQKEIGWG---SQIRSYVFhPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDAYL 322
PCRF smart00937
This domain is found in peptide chain release factors;
66-179 1.09e-52

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 169.95  E-value: 1.09e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329    66 LADKSTDKDMRELAEMELPEIE-SRIEELEKDMQVLLLPKDAADEKSAILEIRAGTGGSEAALFAGDLFRMYERFAASKG 144
Cdd:smart00937   2 LLEEEEDDEMRELAEEELEELEaELEEELEELLKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERKG 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 737226329   145 WKVEVLSASEGEAGGYKEIIATISGRGVFSKLKFE 179
Cdd:smart00937  82 WKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 214-320 3.61e-32

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 117.54  E-value: 3.61e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329 214 DIEIRPEDIRIDTMRASGAGGQHVNTTDSAVRITH------------LPTGLIVTS-SEKSQHQNRAKAMQVLRSRLYDI 280
Cdd:COG1186   20 EIEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAqEERSQHQNREDALKRLKALLYEA 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 737226329 281 ERQKVdsERSADRKSQVGSGDRSE--RIRtynfpqGRVTDHR 320
Cdd:COG1186  100 ELEPK--ERRATKPTRGSKKRRLWgkQIR------SMVKDLR 133
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 114-293 2.94e-24

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 98.31  E-value: 2.94e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329  114 LEIRAGTGGSEAALFAGDLFRMYERFAASKGWKVEVLsasEGEAGgykEIIATIsgRGVFSKLKFESGVHRVQRVPET-- 191
Cdd:TIGR03072   3 LQLSSAQGPAECCLAVAKALERLTREAAARGVRVEVL---EQEPG---EVPGTL--RSALVSLDGEAAAALADRWEGTll 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329  192 ---EASGRIHTSAAT--VAVLPEAEEIDIEirPEDIRIDTMRASGAGGQHVNTTDSAVRITHLPTGLIV-TSSEKSQHQN 265
Cdd:TIGR03072  75 wicPSPYRPHHRRKNwfIGVQRFSASEEAT--EDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVkVQSERSQHAN 152

                         170       180
                  ....*....|....*....|....*...
gi 737226329  266 RAKAMQVLRSRLYDIERQKVDSERSADR 293
Cdd:TIGR03072 153 KRLATLLLAVRLADLQQEQAAALRAERR 180
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
214-270 4.37e-07

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 48.61  E-value: 4.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737226329 214 DIEIRPEDIRIDTMRASGAGGQHVNTTDSAV------RITHLP---------------TG---LIVTSSE-KSQHQNRAK 268
Cdd:PRK09256   7 RLVIPENELEWRFIRASGPGGQNVNKVSTAVelrfdiAASSLPefykerllalaghriTKdgvIVIKAQEfRSQERNRED 86


                 ..
gi 737226329 269 AM 270
Cdd:PRK09256  87 AL 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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