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Conserved domains on  [gi|737230985|ref|WP_035215318|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [unclassified Agrobacterium]

Protein Classification

XRE family transcriptional regulator( domain architecture ID 11443577)

XRE (Xenobiotic Response Element) family transcriptional regulator is a helix-turn-helix domain-containing transcriptional regulator with a peptidase S24 LexA-like domain

Gene Ontology:  GO:0003677
PubMed:  10473770|15808743|10556324

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG2932 COG2932
Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains [Mobilome: ...
 101-224 3.15e-14

Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains [Mobilome: prophages, transposons];


:

Pssm-ID: 442176  Cd Length: 121  Bit Score: 66.91  E-value: 3.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737230985 101 VEVLGVAVGGDDGDFTLNGEVSGYVRRPPgiAHLRKVFALHVLSESMIPRYDPGELIYC--GGREPVPGDHVVIEMYped 178
Cdd:COG2932    1 VPLYDGEASAGGGAFNEVEEPVDKLEFPG--LPPDNLFAVRVSGDSMEPTIRDGDIVLVdpSDTEIRDGGIYVVRTD--- 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 737230985 179 datvGKAYVKKLKARTKGKVICEQYNP---PKELDF-DGYAIKSMWRIIP 224
Cdd:COG2932   76 ----GELLVKRLQRRPDGKLRLISDNPaypPIEIPPeDADEIEIIGRVVW 121
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
4-90 5.79e-14

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


:

Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 65.02  E-value: 5.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737230985   4 NELRKKIGQAIRTARIRRGLVMRDLAEAGGVSTGAVGNWERGANAIAMEHLQAISRKLRIDPVALsngdlryLDDEENLA 83
Cdd:COG1396    2 STLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDEL-------LGGADEEL 74


                 ....*..
gi 737230985  84 DAEQVTD 90
Cdd:COG1396   75 PEALLSE 81
 
Name Accession Description Interval E-value
COG2932 COG2932
Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains [Mobilome: ...
 101-224 3.15e-14

Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains [Mobilome: prophages, transposons];


Pssm-ID: 442176  Cd Length: 121  Bit Score: 66.91  E-value: 3.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737230985 101 VEVLGVAVGGDDGDFTLNGEVSGYVRRPPgiAHLRKVFALHVLSESMIPRYDPGELIYC--GGREPVPGDHVVIEMYped 178
Cdd:COG2932    1 VPLYDGEASAGGGAFNEVEEPVDKLEFPG--LPPDNLFAVRVSGDSMEPTIRDGDIVLVdpSDTEIRDGGIYVVRTD--- 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 737230985 179 datvGKAYVKKLKARTKGKVICEQYNP---PKELDF-DGYAIKSMWRIIP 224
Cdd:COG2932   76 ----GELLVKRLQRRPDGKLRLISDNPaypPIEIPPeDADEIEIIGRVVW 121
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
4-90 5.79e-14

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 65.02  E-value: 5.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737230985   4 NELRKKIGQAIRTARIRRGLVMRDLAEAGGVSTGAVGNWERGANAIAMEHLQAISRKLRIDPVALsngdlryLDDEENLA 83
Cdd:COG1396    2 STLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDEL-------LGGADEEL 74


                 ....*..
gi 737230985  84 DAEQVTD 90
Cdd:COG1396   75 PEALLSE 81
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 11-68 2.65e-10

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 54.48  E-value: 2.65e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 737230985  11 GQAIRTARIRRGLVMRDLAEAGGVSTGAVGNWERGANAIAMEHLQAISRKLRIDPVAL 68
Cdd:cd00093    1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 14-68 3.12e-09

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 51.39  E-value: 3.12e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 737230985   14 IRTARIRRGLVMRDLAEAGGVSTGAVGNWERGANAIAMEHLQAISRKLRIDPVAL 68
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
14-68 1.51e-08

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 49.44  E-value: 1.51e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 737230985    14 IRTARIRRGLVMRDLAEAGGVSTGAVGNWERGANAIAMEHLQAISRKLRIDPVAL 68
Cdd:smart00530   2 LKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
S24_LexA-like cd06529
Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of ...
 138-223 3.11e-08

Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The LexA-like proteins contain two-domains: an N-terminal DNA binding domain and a C-terminal domain (CTD) that provides LexA dimerization as well as cleavage activity. They undergo autolysis, cleaving at an Ala-Gly or a Cys-Gly bond, separating the DNA-binding domain from the rest of the protein. In the presence of single-stranded DNA, the LexA, UmuD and MucA proteins interact with RecA, activating self cleavage, thus either derepressing transcription in the case of LexA or activating the lesion-bypass polymerase in the case of UmuD and MucA. The LexA proteins are serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases. LexA sequence homologs are found in almost all of the bacterial genomes sequenced to date, covering a large number of phyla, suggesting both, an ancient origin and a widespread distribution of lexA and the SOS response.


Pssm-ID: 119397 [Multi-domain]  Cd Length: 81  Bit Score: 49.48  E-value: 3.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737230985 138 FALHVLSESMIPRYDPGELIYC-GGREPVPGDHVVIEmypeddaTVGKAYVKKLKARTKGKVICEQYNP---PKELDFDG 213
Cdd:cd06529    1 FALRVKGDSMEPTIPDGDLVLVdPSDTPRDGDIVVAR-------LDGELTVKRLQRRGGGRLRLISDNPaypPIEIDEEE 73

                         90
                 ....*....|
gi 737230985 214 YAIksmWRII 223
Cdd:cd06529   74 LEI---VGVV 80
PRK09706 PRK09706
transcriptional repressor DicA; Reviewed
 8-72 6.13e-06

transcriptional repressor DicA; Reviewed


Pssm-ID: 182039 [Multi-domain]  Cd Length: 135  Bit Score: 44.46  E-value: 6.13e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 737230985   8 KKIGQAIRTARIRRGLVMRDLAEAGGVSTGAVGNWERGANAIAMEHLQAISRKLRIDPVALSNGD 72
Cdd:PRK09706   4 LTLGQRIRYRRKQLKLSQRSLAKAVKVSHVSISQWERDETEPTGKNLFALAKALQCSPTWLLFGD 68
couple_hipB TIGR03070
transcriptional regulator, y4mF family; Members of this family belong to a clade of ...
 8-57 1.01e-04

transcriptional regulator, y4mF family; Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions]


Pssm-ID: 213767 [Multi-domain]  Cd Length: 58  Bit Score: 39.18  E-value: 1.01e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 737230985    8 KKIGQAIRTARIRRGLVMRDLAEAGGVSTGAVGNWERGANAIAMEHLQAI 57
Cdd:TIGR03070   1 KQIGILVRARRKALGLTQADLADLAGVGLRFIRDLENGKPTVRLDKVLRV 50
Peptidase_S24 pfam00717
Peptidase S24-like;
120-205 2.97e-03

Peptidase S24-like;


Pssm-ID: 425835  Cd Length: 116  Bit Score: 36.41  E-value: 2.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737230985  120 EVSGYVRRPPG-IAHLRKVFALHVLSESMIPRYDPGELIYC-GGREPVPGDHVVIEmypeddaTVGKAYVKKLKaRTKGK 197
Cdd:pfam00717  17 EIEGYLPLPESlLSPPGNLFALRVKGDSMEPGIPDGDLVLVdPSREARNGDIVVAR-------LDGEATVKRLY-RDGGG 88


                  ....*...
gi 737230985  198 VICEQYNP 205
Cdd:pfam00717  89 IRLISLNP 96
 
Name Accession Description Interval E-value
COG2932 COG2932
Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains [Mobilome: ...
 101-224 3.15e-14

Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains [Mobilome: prophages, transposons];


Pssm-ID: 442176  Cd Length: 121  Bit Score: 66.91  E-value: 3.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737230985 101 VEVLGVAVGGDDGDFTLNGEVSGYVRRPPgiAHLRKVFALHVLSESMIPRYDPGELIYC--GGREPVPGDHVVIEMYped 178
Cdd:COG2932    1 VPLYDGEASAGGGAFNEVEEPVDKLEFPG--LPPDNLFAVRVSGDSMEPTIRDGDIVLVdpSDTEIRDGGIYVVRTD--- 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 737230985 179 datvGKAYVKKLKARTKGKVICEQYNP---PKELDF-DGYAIKSMWRIIP 224
Cdd:COG2932   76 ----GELLVKRLQRRPDGKLRLISDNPaypPIEIPPeDADEIEIIGRVVW 121
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
4-90 5.79e-14

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 65.02  E-value: 5.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737230985   4 NELRKKIGQAIRTARIRRGLVMRDLAEAGGVSTGAVGNWERGANAIAMEHLQAISRKLRIDPVALsngdlryLDDEENLA 83
Cdd:COG1396    2 STLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDEL-------LGGADEEL 74


                 ....*..
gi 737230985  84 DAEQVTD 90
Cdd:COG1396   75 PEALLSE 81
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 11-68 2.65e-10

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 54.48  E-value: 2.65e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 737230985  11 GQAIRTARIRRGLVMRDLAEAGGVSTGAVGNWERGANAIAMEHLQAISRKLRIDPVAL 68
Cdd:cd00093    1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 14-68 3.12e-09

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 51.39  E-value: 3.12e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 737230985   14 IRTARIRRGLVMRDLAEAGGVSTGAVGNWERGANAIAMEHLQAISRKLRIDPVAL 68
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
7-68 1.41e-08

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 49.85  E-value: 1.41e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 737230985   7 RKKIGQAIRTARIRRGLVMRDLAEAGGVSTGAVGNWERGANAIAMEHLQAISRKLRIDPVAL 68
Cdd:COG1476    2 KKKLGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKYNPSLELALKIARALGVSLEEL 63
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
14-68 1.51e-08

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 49.44  E-value: 1.51e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 737230985    14 IRTARIRRGLVMRDLAEAGGVSTGAVGNWERGANAIAMEHLQAISRKLRIDPVAL 68
Cdd:smart00530   2 LKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
S24_LexA-like cd06529
Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of ...
 138-223 3.11e-08

Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The LexA-like proteins contain two-domains: an N-terminal DNA binding domain and a C-terminal domain (CTD) that provides LexA dimerization as well as cleavage activity. They undergo autolysis, cleaving at an Ala-Gly or a Cys-Gly bond, separating the DNA-binding domain from the rest of the protein. In the presence of single-stranded DNA, the LexA, UmuD and MucA proteins interact with RecA, activating self cleavage, thus either derepressing transcription in the case of LexA or activating the lesion-bypass polymerase in the case of UmuD and MucA. The LexA proteins are serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases. LexA sequence homologs are found in almost all of the bacterial genomes sequenced to date, covering a large number of phyla, suggesting both, an ancient origin and a widespread distribution of lexA and the SOS response.


Pssm-ID: 119397 [Multi-domain]  Cd Length: 81  Bit Score: 49.48  E-value: 3.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737230985 138 FALHVLSESMIPRYDPGELIYC-GGREPVPGDHVVIEmypeddaTVGKAYVKKLKARTKGKVICEQYNP---PKELDFDG 213
Cdd:cd06529    1 FALRVKGDSMEPTIPDGDLVLVdPSDTPRDGDIVVAR-------LDGELTVKRLQRRGGGRLRLISDNPaypPIEIDEEE 73

                         90
                 ....*....|
gi 737230985 214 YAIksmWRII 223
Cdd:cd06529   74 LEI---VGVV 80
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 5-66 5.01e-07

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 45.70  E-value: 5.01e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 737230985   5 ELRKKIGQAIRTARIRRGLVMRDLAEAGGVSTGAVGNWERGANAIAMEHLQAISRKLRIDPV 66
Cdd:COG1813    8 ELVEDYGERIREAREARGLSQEELAEKLGVSESTIRRIERGEATPSLDTLRKLEKALGISLA 69
PRK09706 PRK09706
transcriptional repressor DicA; Reviewed
 8-72 6.13e-06

transcriptional repressor DicA; Reviewed


Pssm-ID: 182039 [Multi-domain]  Cd Length: 135  Bit Score: 44.46  E-value: 6.13e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 737230985   8 KKIGQAIRTARIRRGLVMRDLAEAGGVSTGAVGNWERGANAIAMEHLQAISRKLRIDPVALSNGD 72
Cdd:PRK09706   4 LTLGQRIRYRRKQLKLSQRSLAKAVKVSHVSISQWERDETEPTGKNLFALAKALQCSPTWLLFGD 68
couple_hipB TIGR03070
transcriptional regulator, y4mF family; Members of this family belong to a clade of ...
 8-57 1.01e-04

transcriptional regulator, y4mF family; Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions]


Pssm-ID: 213767 [Multi-domain]  Cd Length: 58  Bit Score: 39.18  E-value: 1.01e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 737230985    8 KKIGQAIRTARIRRGLVMRDLAEAGGVSTGAVGNWERGANAIAMEHLQAI 57
Cdd:TIGR03070   1 KQIGILVRARRKALGLTQADLADLAGVGLRFIRDLENGKPTVRLDKVLRV 50
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
9-80 1.50e-04

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 38.97  E-value: 1.50e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 737230985   9 KIGQAIRTARIRRGLVMRDLAEAGGVSTGAVGNWERG-ANAIAMEHLQAISRKLRIDPvalsnGDL-RYLDDEE 80
Cdd:COG3655    1 MIYVKLDELLAERGMTKKELAEATGISRATLSRLKNGkAKAVRLDTLEKICKALDCQP-----GDLlEYVPDEE 69
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 8-199 1.92e-04

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 41.05  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737230985   8 KKIGQAIRTARIRRGLV--MRDLAEAGGVSTGAVgnwerganaiaMEHLQAISRKlridpvalsngdlRYLDDEENLADA 85
Cdd:COG1974    9 REILDFIKEYIRERGYPpsQREIAEALGLSSSAV-----------HRHLKALEKK-------------GYLRRDPGKSRA 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737230985  86 EQVTdfgPAPTGPMDVEVLG-VAVGGddgdFTLNGE-VSGYVRRPPGIAHLRK-VFALHVLSESMIpryDPGelIYCG-- 160
Cdd:COG1974   65 IELL---PASPEVVGLPLLGrVAAGF----PIPAEEnIEEYLDLPEELVKNPGaTFALRVKGDSMI---DAG--ILDGdl 132

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 737230985 161 -----GREPVPGDHVVIEMypEDDATvgkayVKKLKaRTKGKVI 199
Cdd:COG1974  133 vivdrQLEAENGDIVVALI--DGEAT-----VKRLY-KEGGRVR 168
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 5-68 9.16e-04

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 36.71  E-value: 9.16e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737230985   5 ELRKKIGQAIRTARIRRGLVMRDLAEAGGVSTGAVGNWERG------ANAIAMEHLQAISRKLRIDPVAL 68
Cdd:COG1426    1 EALETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGdfdalpGPVYVRGFLRSYARALGLDPEEL 70
PRK13355 PRK13355
bifunctional HTH-domain containing protein/aminotransferase; Provisional
 8-86 2.30e-03

bifunctional HTH-domain containing protein/aminotransferase; Provisional


Pssm-ID: 237361 [Multi-domain]  Cd Length: 517  Bit Score: 38.56  E-value: 2.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737230985   8 KKIGQAIRTARIRRGLVMRDLAEAGG-----VSTGAVGNWERGANAIAMEHLQAISRKLRIDPVALSNGDLRYLDDEENL 82
Cdd:PRK13355   2 TTFAERLKQAMKARGLKQEDLVHAAEargvkLGKSHISQYVSGKTGPRRDVLPFLAAILGVSEDWLLGGESPADQESDAS 81


                 ....
gi 737230985  83 ADAE 86
Cdd:PRK13355  82 AVVE 85
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 9-68 2.93e-03

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 36.15  E-value: 2.93e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 737230985   9 KIGQAIRTARIRRGLVMRDLAEAGGVSTGAVGNWERGANAIAMEHLQAISRKLRIDPVAL 68
Cdd:COG3620   17 TLGEALRLMRKELGLSQLPVAELVGVSQSDILRIESGKRDPTVSTLEKIAEALGKELSAV 76
Peptidase_S24 pfam00717
Peptidase S24-like;
120-205 2.97e-03

Peptidase S24-like;


Pssm-ID: 425835  Cd Length: 116  Bit Score: 36.41  E-value: 2.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737230985  120 EVSGYVRRPPG-IAHLRKVFALHVLSESMIPRYDPGELIYC-GGREPVPGDHVVIEmypeddaTVGKAYVKKLKaRTKGK 197
Cdd:pfam00717  17 EIEGYLPLPESlLSPPGNLFALRVKGDSMEPGIPDGDLVLVdPSREARNGDIVVAR-------LDGEATVKRLY-RDGGG 88


                  ....*...
gi 737230985  198 VICEQYNP 205
Cdd:pfam00717  89 IRLISLNP 96
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
11-68 4.55e-03

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 34.52  E-value: 4.55e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 737230985  11 GQAIRTARIRRGLVMRDLAEAGGVSTGAVGNWERGANAIAMEHLQAIsRKLRIDPVAL 68
Cdd:COG2944    8 PEEIRALRERLGLSQAEFAALLGVSVSTVRRWEQGRRKPSGAALKLL-RLLEKHPELL 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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