NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|737615220|ref|WP_035585839|]
View 

MULTISPECIES: type IV toxin-antitoxin system AbiEi family antitoxin [Coriobacteriia]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 229396)

helix-turn-helix domain-containing protein may bind DNA and be involved in the regulation of gene expression

Gene Ontology:  GO:0003677|GO:0006355

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AbiEi super family cl44219
Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system ...
 17-172 3.39e-07

Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system [Defense mechanisms];


The actual alignment was detected with superfamily member COG5340:

Pssm-ID: 444124 [Multi-domain]  Cd Length: 203  Bit Score: 48.07  E-value: 3.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737615220  17 GRILFRSRELgTLFGESGDTLRSTIKRLAADGILERVAHDayLYLLfHPNGCDVLGH---IATFLRPGevTYESLESAAS 93
Cdd:COG5340    5 GRGVFTTADA-RAAGLSAGISRRLLSRLVKKGELERVRRG--LYVL-PPAEADKEHDellIAARLVPP--GYISLLSALA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737615220  94 QWGFISQIPLgRISCVTTGAEGLVDTRFGAIEFIHTDDDSNDVkrGILDRM-PRNRLPIATEERCLHDLVSRKRSLELID 172
Cdd:COG5340   79 LHGLTDQIPF-TVYVAVPRRSRPIKIGGPPIRFVRFSKELFFE--GVEEVKiDGGKVRVTSPERTIVDCLRYRNKIGGID 155
 
Name Accession Description Interval E-value
AbiEi COG5340
Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system ...
 17-172 3.39e-07

Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system [Defense mechanisms];


Pssm-ID: 444124 [Multi-domain]  Cd Length: 203  Bit Score: 48.07  E-value: 3.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737615220  17 GRILFRSRELgTLFGESGDTLRSTIKRLAADGILERVAHDayLYLLfHPNGCDVLGH---IATFLRPGevTYESLESAAS 93
Cdd:COG5340    5 GRGVFTTADA-RAAGLSAGISRRLLSRLVKKGELERVRRG--LYVL-PPAEADKEHDellIAARLVPP--GYISLLSALA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737615220  94 QWGFISQIPLgRISCVTTGAEGLVDTRFGAIEFIHTDDDSNDVkrGILDRM-PRNRLPIATEERCLHDLVSRKRSLELID 172
Cdd:COG5340   79 LHGLTDQIPF-TVYVAVPRRSRPIKIGGPPIRFVRFSKELFFE--GVEEVKiDGGKVRVTSPERTIVDCLRYRNKIGGID 155
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 17-53 5.85e-03

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 33.74  E-value: 5.85e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 737615220   17 GRILFRSRELGTLFGESGDTLRSTIKRLAADGILERV 53
Cdd:pfam00392  21 GDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERR 57
 
Name Accession Description Interval E-value
AbiEi COG5340
Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system ...
 17-172 3.39e-07

Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system [Defense mechanisms];


Pssm-ID: 444124 [Multi-domain]  Cd Length: 203  Bit Score: 48.07  E-value: 3.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737615220  17 GRILFRSRELgTLFGESGDTLRSTIKRLAADGILERVAHDayLYLLfHPNGCDVLGH---IATFLRPGevTYESLESAAS 93
Cdd:COG5340    5 GRGVFTTADA-RAAGLSAGISRRLLSRLVKKGELERVRRG--LYVL-PPAEADKEHDellIAARLVPP--GYISLLSALA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737615220  94 QWGFISQIPLgRISCVTTGAEGLVDTRFGAIEFIHTDDDSNDVkrGILDRM-PRNRLPIATEERCLHDLVSRKRSLELID 172
Cdd:COG5340   79 LHGLTDQIPF-TVYVAVPRRSRPIKIGGPPIRFVRFSKELFFE--GVEEVKiDGGKVRVTSPERTIVDCLRYRNKIGGID 155
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 17-53 5.85e-03

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 33.74  E-value: 5.85e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 737615220   17 GRILFRSRELGTLFGESGDTLRSTIKRLAADGILERV 53
Cdd:pfam00392  21 GDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERR 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH