|
Name |
Accession |
Description |
Interval |
E-value |
| PBP1_ABC_LIVBP-like |
cd06342 |
type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active ... |
27-362 |
2.11e-113 |
|
type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); This subgroup includes the type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine). This subgroup also includes a leucine-specific binding protein (or LivK), which is very similar in sequence and structure to leucine-isoleucine-valine binding protein (LIVBP). ABC-type active transport systems are transmembrane proteins that function in the transport of diverse sets of substrates across extra- and intracellular membranes, including carbohydrates, amino acids, inorganic ions, dipeptides and oligopeptides, metabolic products, lipids and sterols, and heme, to name a few.
Pssm-ID: 380565 [Multi-domain] Cd Length: 334 Bit Score: 333.34 E-value: 2.11e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 27 TIAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPItvdGQPVRFRIVAEDDQADPRTGVQVAQRLLDRQPAAFFGPENSG 106
Cdd:cd06342 1 KIGVAGPLTGPNAALGQDIRNGAELAVDEINAKGG---GLGFKIELVAQDDACDPAQAVAAAQKLVADGVVAVIGHYNSG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 107 VAIPVARLTNAARVPMLTVAS-NPQLTALGYDNVFRTGASDSVLGASMAAFAAGKLGAKTAAVIDDRTAYGQGLAEQFIA 185
Cdd:cd06342 78 AAIAAAPIYAEAGIPMISPSAtNPKLTEQGYKNFFRVVGTDDQQGPAAADYAAKTLKAKRVAVIHDGTAYGKGLADAFKK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 186 KAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLGGDGICSANMGTVAQTA 265
Cdd:cd06342 158 ALKALGGTVVGREGITPGTTDFSALLTKIKAANPDAVYFGGYYPEAGLLLRQLREAGLKAPFMGGDGIVSPDFIKAAGDA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 266 SRNVYCAMSGSGLDRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLAKTMAAAQTTDPAKLIQALRSASHEGVAGTYA 345
Cdd:cd06342 238 AEGVYATTPGAPPEKLPAAKAFLKAYKAKFGEPPGAYAAYAYDAAQVLLAAIEKAGSTDRAAVAAALRATDFDGVTGTIS 317
|
330
....*....|....*..
gi 737992313 346 FTVRGELMNAPTTVFTF 362
Cdd:cd06342 318 FDAKGDLTGPAFTVYQV 334
|
|
| LivK |
COG0683 |
ABC-type branched-chain amino acid transport system, periplasmic component [Amino acid ... |
25-370 |
2.97e-77 |
|
ABC-type branched-chain amino acid transport system, periplasmic component [Amino acid transport and metabolism];
Pssm-ID: 440447 [Multi-domain] Cd Length: 314 Bit Score: 240.60 E-value: 2.97e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 25 VVTIAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPItVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDRQ-PAAFFGPE 103
Cdd:COG0683 3 PIKIGVLLPLTGPYAALGQPIKNGAELAVEEINAAGG-VLGRKIE--LVVEDDASDPDTAVAAARKLIDQDkVDAIVGPL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 104 NSGVAIPVARLTNAARVPMLTV-ASNPQLT-ALGYDNVFRTGASDSVLGASMAAFAAGKLGAKTAAVIDDRTAYGQGLAE 181
Cdd:COG0683 80 SSGVALAVAPVAEEAGVPLISPsATAPALTgPECSPYVFRTAPSDAQQAEALADYLAKKLGAKKVALLYDDYAYGQGLAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 182 QFIAKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLlggdgicsanmgtv 261
Cdd:COG0683 160 AFKAALKAAGGEVVGEEYYPPGTTDFSAQLTKIKAAGPDAVFLAGYGGDAALFIKQAREAGLKGPL-------------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 262 aqtasrnvycamsgsgldrteaGRDYVARYRARFKSEPQTYGITYYDGMLLLAKTMAAAQTTDPAKLIQALRSASHEGVA 341
Cdd:COG0683 226 ----------------------NKAFVKAYKAKYGREPSSYAAAGYDAALLLAEAIEKAGSTDREAVRDALEGLKFDGVT 283
|
330 340 350
....*....|....*....|....*....|
gi 737992313 342 GTYAFTVRGELMNaPTTVFTFE-DGQMVPV 370
Cdd:COG0683 284 GPITFDPDGQGVQ-PVYIVQVKaDGKFVVV 312
|
|
| PBP1_ABC_LivK_ligand_binding-like |
cd06347 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
28-346 |
7.08e-77 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380570 [Multi-domain] Cd Length: 334 Bit Score: 240.14 E-value: 7.08e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 28 IAFSGPLTGPQAVSGKDDENGLRLAVETLNRTpITVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDR-QPAAFFGPENSG 106
Cdd:cd06347 2 IGVIGPLTGEAAAYGQPALNGAELAVDEINAA-GGILGKKIE--LIVYDNKSDPTEAANAAQKLIDEdKVVAIIGPVTSS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 107 VAIPVARLTNAARVPMLT-VASNPQLTALGyDNVFRTGASDSVLGASMAAFAAGKLGAKTAAVIDDRT-AYGQGLAEQFI 184
Cdd:cd06347 79 IALAAAPIAQKAKIPMITpSATNPLVTKGG-DYIFRACFTDPFQGAALAKFAYEELGAKKAAVLYDVSsDYSKGLAKAFK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 185 AKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLGGDGICSANMGTVAQT 264
Cdd:cd06347 158 EAFEKLGGEIVAEETYTSGDTDFSAQLTKIKAANPDVIFLPGYYEEAALIIKQARELGITAPILGGDGWDSPELLELGGD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 265 ASRNVYCAMSGSGLDRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLAKTMAAAQTTDPAKLIQALRSASH-EGVAGT 343
Cdd:cd06347 238 AVEGVYFTTHFSPDDPSPEVQEFVKAYKAKYGEPPNAFAALGYDAVMLLADAIKRAGSTDPEAIRDALAKTKDfEGVTGT 317
|
...
gi 737992313 344 YAF 346
Cdd:cd06347 318 ITF 320
|
|
| PBP1_ABC_transporter_LIVBP-like |
cd06268 |
periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the ... |
27-314 |
1.17e-63 |
|
periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type 1 periplasmic binding fold protein superfamily; Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type 1 periplasmic binding fold protein superfamily. They are mostly present in archaea and eubacteria, and are primarily involved in scavenging solutes from the environment. ABC-type transporters couple ATP hydrolysis with the uptake and efflux of a wide range of substrates across bacterial membranes, including amino acids, peptides, lipids and sterols, and various drugs. These systems are comprised of transmembrane domains, nucleotide binding domains, and in most bacterial uptake systems, periplasmic binding proteins (PBPs) which transfer the ligand to the extracellular gate of the transmembrane domains. These PBPs bind their substrates selectively and with high affinity. Members of this group include ABC-type Leucine-Isoleucine-Valine-Binding Proteins (LIVBP), which are homologous to the aliphatic amidase transcriptional repressor, AmiC, of Pseudomonas aeruginosa. The uncharacterized periplasmic components of various ABC-type transport systems are included in this group.
Pssm-ID: 380492 [Multi-domain] Cd Length: 298 Bit Score: 204.87 E-value: 1.17e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 27 TIAFSGPLTGPQAVSGKDDENGLRLAVETLNRTpITVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDRQ-PAAFFGPENS 105
Cdd:cd06268 1 KIGVVVPLTGPYADYGEEILRGVALAVEEINAA-GGINGRKLE--LVIADDQGDPETAVAVARKLVDDDkVLAVVGHYSS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 106 GVAIPVARLTNAARVPMLTV-ASNPQLTALGYDNVFRTGASDSVLGASMAAFAAGKLGAKTAAVIDDRTAYGQGLAEQFI 184
Cdd:cd06268 78 SVTLAAAPIYQEAGIPLISPgSTAPELTEGGGPYVFRTVPSDAMQAAALADYLAKKLKGKKVAILYDDYDYGKSLADAFK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 185 AKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLGGDGICSANMGTVAQT 264
Cdd:cd06268 158 KALKALGGEIVAEEDFPLGTTDFSAQLTKIKAAGPDVLFLAGYGADAANALKQARELGLKLPILGGDGLYSPELLKLGGE 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 737992313 265 ASRNVYCAMSGSGLDRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLA 314
Cdd:cd06268 238 AAEGVVVAVPWHPDSPDPPKQAFVKAYKKKYGGPPSWRAATAYDATQALA 287
|
|
| PBP1_ABC_ligand_binding-like |
cd19980 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
28-351 |
1.41e-61 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380635 [Multi-domain] Cd Length: 334 Bit Score: 200.91 E-value: 1.41e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 28 IAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPItVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDRQ-PAAFFGPENSG 106
Cdd:cd19980 2 IGVIAPLSGPVAALGQQVLNGAKLAVEEINAKGG-VLGRKLE--LVVEDDKCPPAEGVAAAKKLITDDkVPAIIGAWCSS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 107 VAIPVARLTNAARVPMLT-VASNPQLTALGYDNVFRTGASDSVLGASMAAFAAGKLGAKTAAVIDDRTAYGQGLAEQFIA 185
Cdd:cd19980 79 VTLAVMPVAERAKVPLVVeISSAPKITEGGNPYVFRLNPTNSMLAKAFAKYLADKGKPKKVAFLAENDDYGRGAAEAFKK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 186 KAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLGGDGICSANMGTVAQTA 265
Cdd:cd19980 159 ALKAKGVKVVATEYFDQGQTDFTTQLTKLKAANPDAIFVVAETEDGALILKQARELGLKQQLVGTGGTTSPDLIKLAGDA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 266 SRNVYCAMSGSGLDRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLAKTMAAAQTTDPAKLI-QALRSASHEGVAGTY 344
Cdd:cd19980 239 AEGVYGASIYAPTADNPANKAFVAAYKKKYGEPPDKFAALGYDAVMVIAEAIKKAGSTDPEKIRaAALKKVDYKGPGGTI 318
|
....*..
gi 737992313 345 AFTVRGE 351
Cdd:cd19980 319 KFDEKGQ 325
|
|
| PBP1_ABC_ligand_binding-like |
cd19984 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
27-314 |
3.03e-61 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380639 [Multi-domain] Cd Length: 296 Bit Score: 198.60 E-value: 3.03e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 27 TIAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPiTVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDR-QPAAFFGPENS 105
Cdd:cd19984 1 KIGVILPLTGDAASYGEDMKNGIELAVEEINAAG-GINGKKIE--LIYEDSKCDPKKAVSAANKLINVdKVKAIIGGVCS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 106 GVAIPVARLTNAARVPML-TVASNPQLTALGyDNVFRTGASDSVLGASMAAFAAGKLgAKTAAVIDDRTAYGQGLAEQFI 184
Cdd:cd19984 78 SETLAIAPIAEQNKVVLIsPGASSPEITKAG-DYIFRNYPSDAYQGKVLAEFAYNKL-YKKVAILYENNDYGVGLKDVFK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 185 AKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLGGDGICSANMGTVAQT 264
Cdd:cd19984 156 KEFEELGGKIVASESFEQGETDFRTQLTKIKAANPDAIFLPGYPKEGGLILKQAKELGIKAPILGSDGFEDPELLEIAGE 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 737992313 265 ASRNVYCAMSGSGLDRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLA 314
Cdd:cd19984 236 AAEGVIFTYPAFDDSSEKKQKFFFYRYKEKYGKEPDIYAALAYDAVMILA 285
|
|
| PBP1_ABC_HAAT-like |
cd06344 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
36-352 |
2.47e-60 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of hydrophobic amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of hydrophobic amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380567 [Multi-domain] Cd Length: 332 Bit Score: 197.45 E-value: 2.47e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 36 GPQAVSGKDDENGLRLAVETLNRTPItVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDR-QPAAFFGPENSGVAIPVARL 114
Cdd:cd06344 8 WPFAPDGDLFLEGVELAVEEINAAGG-VLGRKIR--LVEYDDEASVDKGLAIAQRFADNpDVVAVIGHRSSYVAIPASII 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 115 TNAARVPMLTV-ASNPQLTALGYDNVFRTGASDSVLGASMAAFAAgKLGAKTAAVIDDRTAYGQGLAEQFIAKAKSLGLQ 193
Cdd:cd06344 85 YERAGLLMLSPgATAPKLTQHGFKYIFRNIPSDEDIARQLARYAA-RQGYKRIVIYYDDDSYGKGLANAFEEEARELGIT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 194 VVAREFTHSQATDFLAILATIKGKNP-DVIFFGGYTAQAAPMAKQMVQRGVRARLLGGDGICSANMGTVAQTASRNVYCA 272
Cdd:cd06344 164 IVDRRSYSSDEEDFRRLLSKWKALDFfDAIFLAGSMPEGAEFIKQARELGIKVPIIGGDGLDSPELIEIAGKAAEGVVVA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 273 MSGSGLDRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLAKTMAAAQTTDPAKLIQALRSASH-EGVAGTYAFTVRGE 351
Cdd:cd06344 244 TVFDPDDPRPEVRAFVEAFRKKYGREPDVWAAQGYDAVKLLAEAIEKAGSTVPAKIASALRFLENwEGVTGTYSFDANGD 323
|
.
gi 737992313 352 L 352
Cdd:cd06344 324 V 324
|
|
| PBP1_ABC_ligand_binding-like |
cd06336 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
28-347 |
1.34e-56 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This group includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, their ligand specificity has not been determined experimentally.
Pssm-ID: 380559 [Multi-domain] Cd Length: 345 Bit Score: 188.21 E-value: 1.34e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 28 IAFSGPLTGPQAVSGKDDENGLRLAVETLNRTP-ITVDGQPVRFRIVAEDDQADPRTGVQVAQRLLDRQPAAF-FGPENS 105
Cdd:cd06336 2 IGFLGPLSGPAAAWGLPMLRGLELAADEINAAGgIKVGGKKYKVEVVSYDDKYTPAEAVAAARRLVSQDGVKFiFGPGGS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 106 GVAIPVARLTNAARVPMLTVASNPQLTALGYDNVFRTGASDSVLGASMAAFAAGKLGAKTAAVIDDRTAYGQGLAEQFIA 185
Cdd:cd06336 82 AIAAAVQPVTERNKVLLLTAAFSDPILGPDNPLLFRIPPTPYEYAPPFIKWLKKNGPIKTVALIAPNDATGKDWAAAFVA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 186 KAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYT-AQAAPMAKQmvqrgvrARLLGGDGICSANMGTVAQT 264
Cdd:cd06336 162 AWKAAGGEVVAEEFYDRGTTDFYPVLTKILALKPDALDLGGSSpGPAGLIIKQ-------ARELGFKGPFVSEGGAKADE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 265 ASRNVY-----CAMSGSGLD----RTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLAKTMAAAQTTDPAKLIQALRSA 335
Cdd:cd06336 235 ILKEVGgeaaeGFIGVLPADddpiASPGAKAFVERYKKKYGEPPNSESALFYDAAYILVKAMEKAGTVDDTKKIRAALAM 314
|
330
....*....|....
gi 737992313 336 SH--EGVAGTYAFT 347
Cdd:cd06336 315 LSpdETLFGKLKWG 328
|
|
| PBP1_ABC_HAAT-like |
cd06349 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
27-366 |
8.46e-56 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380572 [Multi-domain] Cd Length: 338 Bit Score: 185.85 E-value: 8.46e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 27 TIAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPiTVDGQPVRfrIVAEDDQADPRTGVQVAQRLL--DRQPAAFfGPEN 104
Cdd:cd06349 1 KIGVSGPLTGDNAEYGQQFKNGVELAVDEINAAG-GVNGRKLE--LVVYDDQGDPKEAVNIAQKFVsdDKVVAVI-GDFS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 105 SGVAIPVARLTNAARVPML-TVASNPQLTAlGYDNVFRTGASDSVLGASMAAFAAGKLGAKTAAVIDDRTAYGQGLAEQF 183
Cdd:cd06349 77 SSCSMAAAPIYEEAGLVQIsPTASHPDFTK-GGDYVFRNSPTQAVEAPFLADYAVKKLGAKKIAIIYLNTDWGVSAADAF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 184 IAKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLGGDGICSANMGTVAQ 263
Cdd:cd06349 156 KKAAKALGGEIVATEAYLPGTKDFSAQITKIKNANPDAIYLAAYYNDAALIAKQARQLGWDVQIFGSSSLYSPEFIELAG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 264 TASRNVYCAMSGSGLDRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLAKTMAAAQtTDPAKLIQALRSASH-EGVAG 342
Cdd:cd06349 236 DAAEGVYLSSPFFPESPDPEVKEFVKAYKAKYGEDPDDFAARAYDAVNILAEAIEKAG-TDREAIRDALANIKDfSGLTG 314
|
330 340
....*....|....*....|....
gi 737992313 343 TYAFTVRGElMNAPTTVFTFEDGQ 366
Cdd:cd06349 315 TITFDENGD-VLKSLTILVVKDGK 337
|
|
| PBP1_ABC_HAAT-like |
cd19986 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
28-314 |
9.44e-56 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380641 [Multi-domain] Cd Length: 297 Bit Score: 184.37 E-value: 9.44e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 28 IAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPiTVDGQPVRfrIVAEDDQADPRTGVQVAQRLL-DRQPAAFFGPENSG 106
Cdd:cd19986 2 IGVVAPLTGPAALNGEYQKNGAQLALEEINAAG-GVLGRPLE--LVVEDDQGTNTGAVNAVNKLIsDDKVVAVIGPHYST 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 107 VAIPVARLTNAARVPMLTVASNPQLTALGYDNVFRTGASDSVLGASMAAFAAGKLGAKTAAVIDDRTAYGQGLAEQFIAK 186
Cdd:cd19986 79 QVLAVSPLVKEAKIPVITGGTSPKLTEQGNPYMFRIRPSDSVSAKALAKYAVEELGAKKIAILYDNDDFGTGGADVVTAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 187 AKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLGGDGICSANMGTVAQTAS 266
Cdd:cd19986 159 LKALGLEPVAVESYNTGDKDFTAQLLKLKNSGADVIIAWGHDAEAALIARQIRQLGLDVPVIGSSSFATPTVLLLAGEAL 238
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 737992313 267 RNVYCAMSGSGLDRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLA 314
Cdd:cd19986 239 EGIYSVTDFVPSDPDPKVQAFVKKYKAKYGEDPDLYSAWYYDAMYLLA 286
|
|
| PBP1_ABC_ligand_binding-like |
cd06345 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
27-347 |
4.96e-53 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380568 [Multi-domain] Cd Length: 356 Bit Score: 179.38 E-value: 4.96e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 27 TIAFSGPLTgpqAVSGKDDENGLRLAVETLNRTPiTVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDRQPAAF-FGPENS 105
Cdd:cd06345 1 KIGVLGPLS---APAGEAMERGAELAVEEINAAG-GILGRKVE--LVVADTQGKPEDGVAAAERLITEDKVDAiVGGFRS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 106 GVAIPVARLTNAARVP-MLTVASNPQLTAL------GYDNVFRTGASDSVLGASMAAFAA----GKLGAKTAAVIDDRTA 174
Cdd:cd06345 75 EVVLAAMEVAAEYKVPfIVTGAASPAITKKvkkdyeKYKYVFRVGPNNSYLGATVAEFLKdllvEKLGFKKVAILAEDAA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 175 YGQGLAEQFIAKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRArLLGGDGIC 254
Cdd:cd06345 155 WGRGIAEALKKLLPEAGLEVVGVERFPTGTTDFTPILSKIKASGADVIVTIFSGPGGILLVKQWAELGVPA-PLVGINVP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 255 SANMGTVAQTASRNVYCAMSGSGLDR---TEAGRDYVARYRARFKSEPQTYGITYYDGMLLLAKTMAAAQTTDPAKLIQA 331
Cdd:cd06345 234 AQDPEFWENTGGAGEYEITLAFAAPKakvTPKTKPFVDAYKKKYGEAPNYTAYTAYDAIYILAEAIERAGSTDPDALVKA 313
|
330
....*....|....*.
gi 737992313 332 LRSASHEGVAGTYAFT 347
Cdd:cd06345 314 LEKTDYEGVRGRIKFD 329
|
|
| Peripla_BP_6 |
pfam13458 |
Periplasmic binding protein; This family includes a diverse range of periplasmic binding ... |
26-347 |
1.27e-52 |
|
Periplasmic binding protein; This family includes a diverse range of periplasmic binding proteins.
Pssm-ID: 433225 [Multi-domain] Cd Length: 342 Bit Score: 177.85 E-value: 1.27e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 26 VTIAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPiTVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDRQPA-AFFGPEN 104
Cdd:pfam13458 2 IKIGVLTPLSGPYASSGKSSRAGARAAIEEINAAG-GVNGRKIE--LVVADDQGDPDVAAAAARRLVDQDGVdAIVGGVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 105 SGVAIPVARLTNAARVPMLTVASNPqlTALGYDNVFRTGASDSVLGASMAAFAAGKLGAKTAAVIDDRTAYGQGLAEQFI 184
Cdd:pfam13458 79 SAVALAVAEVLAKKGVPVIGPAALT--GEKCSPYVFSLGPTYSAQATALGRYLAKELGGKKVALIGADYAFGRALAAAAK 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 185 AKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRAR--LLGGDGICSANMGTVA 262
Cdd:pfam13458 157 AAAKAAGGEVVGEVRYPLGTTDFSSQVLQIKASGADAVLLANAGADTVNLLKQAREAGLDAKgiKLVGLGGDEPDLKALG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 263 QTASRNVYCAMSGSGLDRTEAGRDYVARYRARFKSE-PQTYGITYYDGMLLLAKTMAAAQTTDPAKLIQALRSASHEGVA 341
Cdd:pfam13458 237 GDAAEGVYATVPFFPDLDNPATRAFVAAFAAKYGEApPTQFAAGGYIAADLLLAALEAAGSPTREAVIAALRALPYDGPF 316
|
....*.
gi 737992313 342 GTYAFT 347
Cdd:pfam13458 317 GPVGFR 322
|
|
| PBP1_ABC_ligand_binding-like |
cd06340 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
33-332 |
5.25e-52 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, their ligand specificity has not been determined experimentally.
Pssm-ID: 380563 [Multi-domain] Cd Length: 352 Bit Score: 176.60 E-value: 5.25e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 33 PLTGPQAVSGKDDENGLRLAVETLN-RTPIT-VDGQPVRFrIVAeDDQADPRTGVQVAQRLLDRQ-PAAFFGPENSGVAI 109
Cdd:cd06340 7 PLSGPLALIGQEAKRGAELAVDEINaAGGIKsLGGAKIEL-VVA-DTQSDPEVAASEAERLITQEgVVAIIGAYSSSVTL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 110 PVARLTNAARVPMLT-VASNPQLTALGYDNVFRTGASDSVLGASMAAF-----AAGKLGAKTAAVIDDRTAYGQGLAEQF 183
Cdd:cd06340 85 AASQVAERYGVPFVTaSAVADEITERGFKYVFRTAPTASQFAEDAVDFlkelaKKKGKKIKKVAIIYEDSAFGTSVAKGL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 184 IAKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRAR-LLGGDGICS-----AN 257
Cdd:cd06340 165 KKAAKKAGLEVVLDEPYPAGATDLSSEVLKLKAAKPDVVFATSYTNDAILLLRTMKELGFKPKaIIGVGGGYSdpeflKA 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 737992313 258 MGTVAQ-TASRNVYCAMSGSGLDRTEAgrdYVARYRARFKSEPQTYGITYYDGMLLLAKTMAAAQTTDPAKLIQAL 332
Cdd:cd06340 245 LGKDAEgVFSVVPWSPDLAKKKPGAKE---VNERYKKKYGEDMTGHAARAYTAAWVLADALERAGSTDPEAIRAAA 317
|
|
| PBP1_ABC_HAAT-like |
cd19981 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
28-314 |
1.21e-51 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380636 [Multi-domain] Cd Length: 297 Bit Score: 174.02 E-value: 1.21e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 28 IAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPiTVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDRQP-AAFFGPENSG 106
Cdd:cd19981 2 IGFFAPLTGPAAADGKSALHGAELAVEQINAAG-GINGKKVE--LVVYDDQASPKQAVNIAQKLIEQDKvVAVVSGSYSG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 107 VAIPVARLTNAARVPML-TVASNPQLTALGyDNVFRTGASDSVLGASMAAFAAGKLGAKTAAVIDDRTAYGQGLAEQFIA 185
Cdd:cd19981 79 PTRAAAPIFQEAKVPMVsAYAVHPDITKAG-DYVFRVAFLGPVQGRAGAEYAVKDLGAKKVAILTIDNDFGKSLAAGFKE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 186 KAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLGGDGICSANMGTVAQTA 265
Cdd:cd19981 158 EAKKLGAEIVSEYAYALGDRDFRPILTKIKSANPDAIYASGYYAEAAPIVKQARELGIKVPIIGQEGYDSPKFIEIAGSA 237
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 737992313 266 SRNVYCAMSGSGLDRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLA 314
Cdd:cd19981 238 AEGVIITTSLNRDSDRPITQKFIKEYRKRYGIDPDMVAASTYDAVMVLA 286
|
|
| PBP1_ABC_ligand_binding-like |
cd06335 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
28-345 |
3.86e-51 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters, such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.
Pssm-ID: 380558 [Multi-domain] Cd Length: 348 Bit Score: 173.95 E-value: 3.86e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 28 IAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPiTVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDRQPA-AFFGPENSG 106
Cdd:cd06335 2 IGVIGPLTGPSAELGESARRGVELAVEEINAAG-GILGRKIE--LVERDDEANPTKAVQNAQELIDKEKVvAIIGPTNSG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 107 VAIPVARLTNAARVP-MLTVASNPQLTALG---YDNVFRTGASDSVLGASMAAFAAGKlGAKTAAVIDDRTAYGQGLAEQ 182
Cdd:cd06335 79 VALATIPILQEAKIPlIIPVATGTAITKPPakpRNYIFRVAASDTLQADFLVDYAVKK-GFKKIAILHDTTGYGQGGLKD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 183 FIAKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLGGDGICSANMGTVA 262
Cdd:cd06335 158 VEAALKKRGITPVATESFKIGDTDMTPQLLKAKDAGADVILVYGLGPDLAQILKAMEKLGWKVPLVGSWGLSMPNFIELA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 263 QTASRNVYCAMSGSGLDRTEAGRDYVARYRARFKSEPQTYGIT---YYDGMLLLAKTMAAAQTTDPAKLIQALRSASH-E 338
Cdd:cd06335 238 GPLAEGTIMTQTFIEDYLTPRAKKFIDAYKKKYGTDRIPSPVSaaqGYDAVYLLAAAIKQAGSTDGKKIRAALENLKGyV 317
|
....*..
gi 737992313 339 GVAGTYA 345
Cdd:cd06335 318 GGVKTYN 324
|
|
| PBP1_ABC_RPA1789-like |
cd06333 |
type 1 periplasmic binding-protein component (CouP) of an ABC system (CouPSTU; RPA1789, ... |
28-347 |
8.00e-51 |
|
type 1 periplasmic binding-protein component (CouP) of an ABC system (CouPSTU; RPA1789, RPA1791-1793), involved in active transport of lignin-derived aromatic substrates, and its close homologs; This group includes RPA1789 (CouP) from Rhodopseudomonas palustris and its close homologs in other bacteria. RPA1789 (CouP) is the periplasmic binding-protein component of an ABC system (CouPSTU; RPA1789, RPA1791-1793) that is involved in the active transport of lignin-derived aromatic substrates. Members of this group has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP).
Pssm-ID: 380556 [Multi-domain] Cd Length: 342 Bit Score: 173.12 E-value: 8.00e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 28 IAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPiTVDGQPVRfrIVAEDDQADPRTGVQVAQRLL-DRQPAAFFGPENSG 106
Cdd:cd06333 2 IGAILSLTGPAASLGIPERNAVELLVEQINAAG-GINGRKLE--LIVYDDESDPTKAVTNARKLIeEDKVDAIIGPSTTG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 107 VAIPVARLTNAARVPMLTVASNPQLTALGYDNVFRTGASDSVLGASMAAFAAGKlGAKTAAVIDDRTAYGQGLAEQFIAK 186
Cdd:cd06333 79 ESLAVAPIAEEAKVPLISLAGAAAIVEPVRKWVFKTPQSDSLVAEAILDYMKKK-GIKKVALLGDSDAYGQSGRAALKKL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 187 AKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLGGDGICSANMGTVAQTAS 266
Cdd:cd06333 158 APEYGIEIVADERFARTDTDMTAQLTKIRAAKPDAVLVWASGPPAALVAKNLRQLGYKGPIYQSHGAANQDFIKLAGKAA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 267 RNVYCAMS----GSGLDRT----EAGRDYVARYRARFKSEPQTYGITYYDGMLLLAKTMAAAQTTDPAKLIQALRSASHE 338
Cdd:cd06333 238 EGVILPAGkllvADQLPDSdpqkKVLLEFVKAYEAKYGEGPSTFAGHAYDALLLLVEAIEPAGGTDRAALRDALENTKGL 317
|
330
....*....|
gi 737992313 339 -GVAGTYAFT 347
Cdd:cd06333 318 vGVTGVYNFS 327
|
|
| PBP1_ABC_ligand_binding-like |
cd06338 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
27-365 |
1.79e-49 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT); however, their ligand specificity has not been determined experimentally.
Pssm-ID: 380561 [Multi-domain] Cd Length: 347 Bit Score: 169.69 E-value: 1.79e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 27 TIAFSGPLTGPQAVSGKDDENGLRLAVETLN-RTPITVDGQPVRFRIVAEDDQADPRTGVQVAQRLLDRQPA-AFFGPEN 104
Cdd:cd06338 1 KIGASLSLTGPFAGEGKAQKRGYELWVEDVNaAGGVKGGGKKRPVELVYYDDQSDPATAVRLYEKLITEDKVdLLLGPYS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 105 SGVAIPVARLTNAARVPMLTV-ASNPQLTALGYDNVFRTGASDSVLGASMAAFAAGK-LGAKTAAVIDDRTAYGQGLAEQ 182
Cdd:cd06338 81 SGLTLAAAPVAEKYGIPMIAGgAASDSIFERGYKYVFGVLPPASDYAKGLLDLLAELgPKPKTVAIVYEDDPFGKEVAEG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 183 FIAKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLGGdGICSANMGTVA 262
Cdd:cd06338 161 AREAAKKAGLEVVYDESYPPGTTDFSPLLTKVKAANPDILLVGGYPPDAITLVRQMKELGYNPKAFFL-TVGPAFPAFRE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 263 QT--ASRNVYCAMS---GSGLDRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLAKTMAAAQTTDPAKLIQALRSASH 337
Cdd:cd06338 240 ALgkDAEGVLGPSQwepSLPYKVFPGAKEFVKAYKEKFGEEPSYHAAAAYAAGQVLQQAIEKAGSLDPEKVRDALASLDF 319
|
330 340
....*....|....*....|....*...
gi 737992313 338 EGVAGTYAFTVRGELMNAPTTVFTFEDG 365
Cdd:cd06338 320 DTVYGPIKFDETGLQIGKPMVVVQWQGG 347
|
|
| PBP1_ABC_HAAT-like |
cd06348 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
33-365 |
4.92e-45 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380571 [Multi-domain] Cd Length: 342 Bit Score: 157.78 E-value: 4.92e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 33 PLTGPQAVSGKDDENGLRLAVETLNRTPItVDGQPVRFriVAEDDQADPRTGVQVAQRLLDR-QPAAFFGPENSGVAIPV 111
Cdd:cd06348 7 SLTGPGALYGQSQKNGAQLAVEEINAAGG-VGGVKIEL--IVEDTAGDPEQAINAFQKLINQdKVLAILGPTLSSEAFAA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 112 ARLTNAARVPMLTVASN-PQLTALGyDNVFRTGA-SDSVLGASMAAFAAgKLGAKTAAVI----DDRTAYGqglAEQFIA 185
Cdd:cd06348 84 DPIAQQAKVPVVGISNTaPGITDIG-PYIFRNSLpEDKVIPPTVKAAKK-KYGIKKVAVLydqdDAFTVSG---TKVFPA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 186 KAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLGGDGICSANMGTVAQTA 265
Cdd:cd06348 159 ALKKNGVEVLDTETFQTGDTDFSAQLTKIKALNPDAIVISALAQEGALIVKQARELGLKGPIVGGNGFNSPDLIKLAGKA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 266 SRNVYCAMSGSGLDRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLAKTMAAA-QTTDPAK----LIQALRSASHEGV 340
Cdd:cd06348 239 AEGVIVGSAWSPDNPDPKNQAFVAAYKEKYGKEPDQFAAQAYDAAYILAEAIKKAgSTTDRADlrdaLARILIAKDFEGP 318
|
330 340
....*....|....*....|....*
gi 737992313 341 AGTYAFTVRGELmNAPTTVFTFEDG 365
Cdd:cd06348 319 LGPFSFDADRDG-IQPPVVLIVKDG 342
|
|
| PBP1_ABC_ligand_binding-like |
cd19982 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
33-330 |
9.14e-45 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, their ligand specificity has not been determined experimentally.
Pssm-ID: 380637 [Multi-domain] Cd Length: 302 Bit Score: 155.90 E-value: 9.14e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 33 PLTGPQAVSGKDDENGLRLAVETLNRTPiTVDGQPVRFriVAEDDQADPRTGVQVAQRLLDRQPAAF-FGPENSGVAIPV 111
Cdd:cd19982 7 SLTGPFAPFGEMFKNGYEMALEEINAAG-GIKGKKLEL--VIEDDQSKPQTALAAAEKLVSQDKVPLiVGGYSSGITLPV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 112 ARLTNAARVPMLTV-ASNPQLTALGYDNVFRTGASDSVLGASMAAFAAGKLGAKTAAVIDDRTAYGQGLAEQFIAKAKSL 190
Cdd:cd19982 84 AAVAERQKIPLLVPtAADDDITKPGYKYVFRLNPPASIYAKALFDFFKELVKPKTIAILYENTAFGTSVAKAARRFAKKR 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 191 GLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLGGDGICSAnMGTVAQTA---SR 267
Cdd:cd19982 164 GIEVVADESYDKGATDFKPLLNKVKAANPDVVYMVSYLNDAILLMRQAKELGLNPKLFAGGGAGFT-IPEFLKQAgplAE 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 737992313 268 NVYCAMSGSGLDRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLlaktmAAAQTTDPAKLIQ 330
Cdd:cd19982 243 YVVTATLWSPDVKYPGAKEFYEKYKAKYGVEPSYHEAEAYAALYV-----AANQNPHPTLVLQ 300
|
|
| PBP1_ABC_HAAT-like |
cd19988 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
28-314 |
1.38e-44 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380643 [Multi-domain] Cd Length: 302 Bit Score: 155.51 E-value: 1.38e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 28 IAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPItVDGQPvrFRIVAEDDQADPRTGVQVAQRLLDRQPA-AFFGPENSG 106
Cdd:cd19988 2 IGVFGPLSGDAAPYGQAMLQGAELAVEEINAAGG-ILGIP--IELVVEDDEGLPAASVSAAKKLIYQDKVwAIIGSINSS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 107 VAIPVARLTNAARVPMLTV-ASNPQLTALGYDNVFRTGASDSVLGASMAAFAAGKLGAKTAAVIDDRTAYGQGLAEQFIA 185
Cdd:cd19988 79 CTLAAIRVALKAGVPQINPgSSAPTITESGNPWVFRCTPDDRQQAYALVDYAFEKLKVTKIAVLYVNDDYGRGGIDAFKD 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 186 KAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLGGDGICSANMGTVAQTA 265
Cdd:cd19988 159 AAKKYGIEVVVEESYNRGDKDFSPQLEKIKDSGAQAIVMWGQYTEGALIAKQARELGLKQPLFGSDGLVTPKFIELAGDA 238
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 737992313 266 SRNVYCAMSGSGLDRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLA 314
Cdd:cd19988 239 AEGAIATTPFLPDSDDPKVSAFVEKYKKRYGEEPDVFAAQAYDAMNILA 287
|
|
| PBP1_As_SBP-like |
cd06330 |
periplasmic substrate-binding domain of active transport proteins; Periplasmic ... |
27-346 |
2.19e-44 |
|
periplasmic substrate-binding domain of active transport proteins; Periplasmic substrate-binding domain of active transport proteins found in bacteria and Archaea that is predicted to be involved in the efflux of toxic compounds. Members of this subgroup include proteins from Herminiimonas arsenicoxydans, which is resistant to arsenic (As) and various heavy metals such as cadmium and zinc. Moreover, they show significant sequence similarity to the cluster of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa.
Pssm-ID: 380553 [Multi-domain] Cd Length: 342 Bit Score: 156.18 E-value: 2.19e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 27 TIAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPItVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDRQPA-AFFGPENS 105
Cdd:cd06330 1 KIGVITPLSGAAAVYGEPARNGAELAVEEINAAGG-ILGRKIE--LVVRDDKGKPDEAVRAARELVLQEGVdFLIGTISS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 106 GVAIPVARLTNAARVPML-TVASNPQLTA-LGYDNVFRTGASDSVLGASMAAFAAGK-LGAKTAAVIDDRTAYGQGLAEQ 182
Cdd:cd06330 78 GVALAVAPVAEELKVLFIaTDAATDRLTEeNFNPYVFRTSPNTYMDAVAAALYAAKKpPDVKRWAGIGPDYEYGRDSWAA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 183 FIAKAKSLG--LQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGV--RARLLGGDGICSANM 258
Cdd:cd06330 158 FKAALKKLKpdVEVVGELWPKLGATDYTAYITALLAAKPDGVFSSLWGGDLVTFVKQAKPYGLfdKTKVVSGLGGGSEVL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 259 GTVAQTASRNVYCAMSGS-GLDRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLAKTMAAAQTTDPAKLIQALRSASH 337
Cdd:cd06330 238 QALGKEMPEGLIGGGRYPfGWPDTPLNKAFVEAYRAKYGEYPTYWAYEAYAAVMALKAAIEKAGSTDTDKVIAALEGLTF 317
|
....*....
gi 737992313 338 EGVAGTYAF 346
Cdd:cd06330 318 DTPGGKITI 326
|
|
| PBP1_ABC_ligand_binding-like |
cd06346 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
33-314 |
8.31e-43 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380569 [Multi-domain] Cd Length: 314 Bit Score: 151.18 E-value: 8.31e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 33 PLTGPQAVSGKDDENGLRLAVETLNRTPItVDGQPVRfrIVAEDDQADPRTGVQVAQRLLD-RQPAAFFGPENSGVAIPV 111
Cdd:cd06346 7 PLTGPLASLGPPMLAAAELAVEEINAAGG-VLGKKVE--LVVEDSQTDPTAAVDAARKLVDvEGVPAIVGAASSGVTLAV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 112 ARLTNAARVPMLTVAS-NPQLTAL-GYDNVFRTGASDSVLGASMAAFAAgKLGAKTAAVIDDRTAYGQGLAEQFIAKAKS 189
Cdd:cd06346 84 ASVAVPNGVVQISPSStSPALTTLeDKGYVFRTAPSDALQGVVLAQLAA-ERGFKKVAVIYVNNDYGQGLADAFKKAFEA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 190 LGLQVVArEFTHSQ-ATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRA-RLLGGDG-ICSANMGTVAQTAS 266
Cdd:cd06346 163 LGGTVTA-SVPYEPgQTSYRAELAQAAAGGPDALVLIGYPEDGATILREALELGLDFtPWIGTDGlKSDDLVEAAGAEAL 241
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 737992313 267 RNVYCAMSGSglDRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLA 314
Cdd:cd06346 242 EGMLGTAPGS--PGSPAYEAFAAAYKAEYGDDPGPFAANAYDAVMLLA 287
|
|
| PRK15404 |
PRK15404 |
high-affinity branched-chain amino acid ABC transporter substrate-binding protein; |
1-361 |
1.96e-41 |
|
high-affinity branched-chain amino acid ABC transporter substrate-binding protein;
Pssm-ID: 237959 [Multi-domain] Cd Length: 369 Bit Score: 149.02 E-value: 1.96e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 1 MKLKCMIAVLALGGFTiGAAHAERVvTIAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPiTVDGQpvRFRIVAEDDQAD 80
Cdd:PRK15404 3 SKGKTLLAGCIALALS-HAALADDI-KIAIVGPMSGPVAQYGDMEFTGARQAIEDINAKG-GIKGD--KLEGVEYDDACD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 81 PRTGVQVAQRLLDRQPAAFFGPENSGVAIPVARLTNAARVPMLT-VASNPQLTALGYDNVFRTGASDSVLGASMAAFAAG 159
Cdd:PRK15404 78 PKQAVAVANKVVNDGIKYVIGHLCSSSTQPASDIYEDEGILMITpAATAPELTARGYQLIFRTIGLDSDQGPTAAKYILE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 160 KLGAKTAAVIDDRTAYGQGLAEQFIAKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMV 239
Cdd:PRK15404 158 KVKPKRIAVLHDKQQYGEGLARSVKDGLKKAGANVVFFEGITAGDKDFSALIAKLKKENVDFVYYGGYHPEMGQILRQAR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 240 QRGVRARLLGGDGICSANMGTVAQTASRNVYCAMSGSgLDRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLAKTMAA 319
Cdd:PRK15404 238 EAGLKTQFMGPEGVGNKSLSNIAGPASEGMLVTLPKR-YDQDPANKAIVDAFKAKKQDPSGPFVWTTYAAVQSLAAGINR 316
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 737992313 320 AQTTDPAKLIQALRSASHEGVAGTYAFTVRGELMNAPTTVFT 361
Cdd:PRK15404 317 AGSDDPAKVAKYLKANTFDTVIGPLSWDEKGDLKGFEFGVFE 358
|
|
| PBP1_aromatic_compounds-like |
cd06332 |
type 1 periplasmic binding proteins of active transport systems predicted to be involved in ... |
27-360 |
4.02e-37 |
|
type 1 periplasmic binding proteins of active transport systems predicted to be involved in transport of aromatic compounds such as 2-nitrobenzoic acid and alkylbenzenes; This group includes the type 1 periplasmic binding proteins of active transport systems that are predicted to be involved in transport of aromatic compounds such as 2-nitrobenzoic acid and alkylbenzenes; their substrate specificities are not well characterized, however. Members also exhibit close similarity to active transport systems for short chain amides and/or urea found in bacteria and archaea.
Pssm-ID: 380555 [Multi-domain] Cd Length: 336 Bit Score: 136.57 E-value: 4.02e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 27 TIAFSGPLTGPQAVSGKDDENGLRLAVETLNRTpitVDGQPVRFriVAEDDQADPRTGVQVAQRLLDRQPAAF-FGPENS 105
Cdd:cd06332 1 KIGLLAPLTGPFAALGEDMVRGFELALEEVGGE---VAGRKVEL--VVEDDAGDPDTAVTKARKLVEQDKVDVlIGPLSG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 106 GVAIPVARLTNAARVPMLTVASNPQLTAL--GYDNVFRTGASDSVLGASMAAFAAGKLGAKTAAVIDDRTAYGQGLAEQF 183
Cdd:cd06332 76 DEGLAVAPYAKEPGVPFINPVAGADDLTQraKAPNFFRTSFTGSQWSAPLGDYAYKELGYKKVATIGSDYAFGYEQAAGF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 184 IAKAKSLGLQVVAREFTHSQATDFLAILATIKgKNPDVIFFGGYTAQAAPMAKQMVQRGVRAR--LLGG----DGICSAN 257
Cdd:cd06332 156 KRGFEAAGGEVVQEIWVPLGTTDFSPYIAQIP-SADDAVFAFLGGADAVRFLKQYREFGLKDKipLIGGgttvDESVLPA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 258 MGTVA---QTASRNVycamsgSGLDrTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLAKTMAAA--QTTDPAKLIQAL 332
Cdd:cd06332 235 MGDAAlgiISASHYA------EGLD-NPENKKFVAAYKKKFGKLPSLYAAGGYDGAQAILEALEAVggDVSDKQALAAAL 307
|
330 340
....*....|....*....|....*...
gi 737992313 333 RSASHEGVAGTYAFtvrGELMNAPTTVF 360
Cdd:cd06332 308 RKVKFDSPRGPFSF---DENRNPVQNVY 332
|
|
| PBP1_SBP-like |
cd19989 |
periplasmic substrate-binding domain of active transport proteins; Periplasmic ... |
27-314 |
1.17e-36 |
|
periplasmic substrate-binding domain of active transport proteins; Periplasmic substrate-binding domain of active transport proteins found in bacteria and Archaea. Members of this group are initial receptors in the process of active transport across cellular membrane, but their substrate specificities are not known in detail. However, they closely resemble the group of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus it may also be involved in transport of amino acids.
Pssm-ID: 380644 [Multi-domain] Cd Length: 299 Bit Score: 134.71 E-value: 1.17e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 27 TIAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPiTVDGQPVRFRIvaEDDQADPRTGVQVAQRLLDRQPAAF-FGPENS 105
Cdd:cd19989 1 KIGVLTPLSGPYAALGEEARRGAQLAVEEINAAG-GILGRPVELVV--EDTEGKPATAVQKARKLVEQDGVDFlTGAVSS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 106 GVAIPVARLTNAARVPML-TVASNPQLT-ALGYDNVFRTGASDSVLGASMAAFAAGKLGAKTAAVIDDrTAYGQGLAEQF 183
Cdd:cd19989 78 AVALAVAPKAAELKVPYLvTVAADDELTgENCNRYTFRVNTSDRMIARALAPWLAENGGKKWYIVYAD-YAWGQSSAEAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 184 IAKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRAR--LLGGDGICSANMGTV 261
Cdd:cd19989 157 KEAIEELGGEVVGTLFAPLGTTDFSSYITQISDSGADGLLLALAGSDAVNFLKQAGQFGLGKKykIVGGILSIEPLALPA 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 737992313 262 AQTASRNVYCAMS-GSGLDrTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLA 314
Cdd:cd19989 237 LGDAAEGVYGGVRyPPTLD-TPANRAFVEAYEKEYGEAPDNFAGEAYEAMQALA 289
|
|
| PBP1_RPA0668_benzoate-like |
cd20014 |
type 1 periplasmic binding-protein component of an ABC system (RPA0668), involved in in the ... |
33-346 |
3.83e-35 |
|
type 1 periplasmic binding-protein component of an ABC system (RPA0668), involved in in the active transport of lignin-derived benzoate derivative compounds, and its close homologs; This group includes RPA0668 from Rhodopseudomonas palustris and its close homologs in other bacteria. Rpa0668 is the periplasmic binding-protein component of an ABC system that is involved in the active transport of lignin-derived benzoate derivative compounds. Members of this group has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP).
Pssm-ID: 380667 [Multi-domain] Cd Length: 346 Bit Score: 131.59 E-value: 3.83e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 33 PLTGPQAVSGKDDENGLRLAVETLNRTpitVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDRQPAAFF-GPENSGVAIPV 111
Cdd:cd20014 7 PYSGVYAALGEDIRNGFQLYLDEHGGK---LGGRPIE--LVKEDDEADPDVALQKARKLIEQDKVDVLvGPVSSGVALAI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 112 ARLTNAARVPML-TVASNPQLT-ALGYDNVFRTGASDSVLGASMAAFAAGKLGaKTAAVIDDRTAYGQGLAEQFIAKAKS 189
Cdd:cd20014 82 RDVVEQAKVPLIvANAGANALTrAACSPYIFRTSFSNWQLGYALGKYAAENVG-KTVVTIASDYAAGREVVAGFKEGFEA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 190 LGLQVVAREFTHSQAT-DFLAILATIKGKNPDVI--FFGGytAQAAPMAKQMVQRGVRARL-LGGDGICsANMGTVAQT- 264
Cdd:cd20014 161 AGGKVVGEIWTPLGTTtDFSPYLTQIAASGPDAVyaFFAG--ADAVRFVKQYAEFGLKGKIpLYGPGFL-TDEDVLPALg 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 265 -ASRNVYCAMSGS-GLDrTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLAKTMAAAQ--TTDPAKLIQALRSASHEGV 340
Cdd:cd20014 238 eAAEGIITVLHYApTLD-NPANRAFVAAYQAKYGRLPDVYAVQGYDAAQVIDAALEAVGgdTSDKDILAAALELGSIDSP 316
|
....*.
gi 737992313 341 AGTYAF 346
Cdd:cd20014 317 RGPFRF 322
|
|
| PBP1_AmiC-like |
cd06331 |
type 1 periplasmic components of amide-binding protein (AmiC) and the active transport system ... |
28-343 |
5.40e-34 |
|
type 1 periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); This group includes the type 1 periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF), found in bacteria and Archaea. AmiC controls expression of the amidase operon by a ligand-triggered conformational switch. In the absence of ligand or presence of butyramide (repressor), AmiC (the ligand sensor and negative regulator) adopts an open conformation and inhibits the transcription antitermination function of AmiR by direct protein-protein interaction. In the presence of inducing ligands such as acetamide, AmiC adopts a closed conformation which disrupts a silencing AmiC-AmiR complex and the expression of amidase and other genes of the operon is induced. FmdDEF is predicted to be an ATP-dependent transporter and closely resembles the periplasmic binding protein and the two transmembrane proteins present in various hydrophobic amino acid-binding transport systems.
Pssm-ID: 380554 [Multi-domain] Cd Length: 333 Bit Score: 128.10 E-value: 5.40e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 28 IAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPiTVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDRQPAAF-FGPENSG 106
Cdd:cd06331 2 IGLLTPLSGPASVYGRAIANGAELAVEEINAAG-GVLGRPVE--LVVEDDASDPATAVAAARRLIQQDKVDAiVGPITSA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 107 VAIPVARLTNAARVPMLTVASNPQLTALGYdnVFRTGAS-DSVLGASMAAFAagKLGAKTAAVIDDRTAYGQGLAEQFIA 185
Cdd:cd06331 79 TRNAVAPVAERAKVPLLYPTFYEGGECSPY--LFCFGEVpNQQLDPLIPWLM--EEYGKKFYLIGSDYVWPRTMNDAARR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 186 KAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARL----LGGDGICSANMGTv 261
Cdd:cd06331 155 VIEAHGGEVVGEEYLPLGTTDFSSVIEKIKASGADVVLSTLVGADAVTFLKQFAAAGLRRKVriaaLLFDENTLAGLGA- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 262 aqTASRNVYCAMSGSGLDRTEAGRDYVARYRARF--KSEPQTY-GITYYDGMLLLAKTMAAAQTTDPAKLIQALRSASHE 338
Cdd:cd06331 234 --EAAEGIYSVLSYFQSLDTPENKAFVAAYRKKFgeDAPPITSlSEAAYEAVHLYAAAVEKAGSTDPEAVIAALPGVSFD 311
|
....*
gi 737992313 339 GVAGT 343
Cdd:cd06331 312 GPQGP 316
|
|
| PBP1_ABC_ligand_binding-like |
cd06343 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
26-334 |
2.20e-33 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however its ligand specificity has not been determined experimentally.
Pssm-ID: 380566 [Multi-domain] Cd Length: 355 Bit Score: 126.91 E-value: 2.20e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 26 VTIAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPiTVDGQPVRFriVAEDDQADPRTGVQVAQRLLDR-QPAAFFGPEN 104
Cdd:cd06343 7 IKIGTSLPLSGPAAAYGKPVRAGAAAYFDEVNAAG-GINGRKIEL--IVEDDGYDPARAVAAVRKLVEQdKVFAIVGGLG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 105 SGVAIPVARLTNAARVPMLTVASN-PQLTALGYDNVFRTGASDSVLGASMAAFAAGKLGAKTAAVIDDRTAYGQGLAEQF 183
Cdd:cd06343 84 TPTNLAVRPYLNEAGVPQLFPATGaSALSPPPKPYTFGVQPSYEDEGRILADYIVETLPAAKVAVLYQNDDFGKDGLEGL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 184 IAKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLGGDGICSAN-MGTVA 262
Cdd:cd06343 164 KEALKAYGLEVVAEETYEPGDTDFSSQVLKLKAAGADVVVLGTLPKEAAAALKEAAKLGWKPTFLGSSVSADPTtLAKAG 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 737992313 263 QTASRNVYCAMSGS--GLDRTEAGRDYVARYRARFKSE-PQTYGIT-YYDGMLLLAKTMAAAQTTDPAKLIQALRS 334
Cdd:cd06343 244 GDAAEGVYSASYLKdpTDADDPAVKEFREAYKKYFPDDpPNAYALYgYAAAQVFVEALKRAGKDLTREGLIKALES 319
|
|
| PBP1_ABC_HAAT-like |
cd19983 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
28-314 |
3.63e-33 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of hydrophobic amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of hydrophobic amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380638 [Multi-domain] Cd Length: 303 Bit Score: 125.39 E-value: 3.63e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 28 IAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPiTVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDRQPAAFFGPENSGV 107
Cdd:cd19983 2 IGFVGGLTGRYSDLGVQGRNGAQLAVEEINAAG-GINGRPVE--LIIRDDQQDPEAAKAADRELIAGGVVAIIGHMTSAM 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 108 AIPVARLTNAARVPMLT-VASNPQLTALGyDNVFRTGASDSVLGASMAAFAAGKLGAKTAAVIDDRT--AYGQGLAEQFI 184
Cdd:cd19983 79 TVAVLPVINEAKVLMISpTVSTPELSGKD-DYFFRVTPTTRESAQALARYAYNRGGLRRVAVIYDLSnrAYSESWLDNFR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 185 AKAKSLGLQVVA-REFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARL-------------LGG 250
Cdd:cd19983 158 SEFEALGGRIVAeIPFSSGADVDFSDLARRLLASKPDGLLLVASAVDTAMLAQQIRKLGSKIPLfssawaateelleLGG 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 737992313 251 ---DGIcsanmgTVAQTASRNvycamsgsglDRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLA 314
Cdd:cd19983 238 kavEGM------LFSQAYDRN----------SSNPRYLAFKEAYEERFGREPSFAAAYAYEAAMVLA 288
|
|
| PBP1_ABC_HAAT-like |
cd19985 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
28-314 |
2.85e-32 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of hydrophobic amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of hydrophobic amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380640 [Multi-domain] Cd Length: 321 Bit Score: 123.15 E-value: 2.85e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 28 IAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPiTVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDRQPAAFFGPENSGV 107
Cdd:cd19985 2 IAVVGPMSGKSASKGKSMLRGAELYIDQINAAG-GINGKKVK--LDVFDDQNDPDAARKAAQIIVSDKALAVIGHYYSSA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 108 AIPVARLTNAARVPMLTV-ASNPQLTAlgyDN--VFRTGASDSVLGASMAAFAAGKLGAKTAAVIDDRTAYGQGLAEQFI 184
Cdd:cd19985 79 SIAAGKIYKKAGIPAITPsATADAVTR---DNpwYFRVIFNDSLQGRFLANYAKKVLKKDKVSIIYEEDSYGKSLASVFE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 185 AKAKSLGLQVVARE-FTHSQAT---DFLAILATIK--GKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLGGDGICSANM 258
Cdd:cd19985 156 ATARALGLKVLKKWsFDTDSSQldqNLDQIVDELKkaPDEPGVIFLATHADEGAKLIKKLRDAGLKAPIIGPDSLASESF 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 737992313 259 GTVAQTA----------SRNVYcAMSGSGLDRT-EAGRDYVARYRARFKSEPQTYGITYYDGMLLLA 314
Cdd:cd19985 236 AQGFAEYpeekeepgyyTDGIY-ATSPFIFDIAnEKAQKFRDTYQKRYGEEPSWIAAFAYDAAMLAI 301
|
|
| PBP1_alkylbenzenes-like |
cd06360 |
type 1 periplasmic binding component of active transport systems predicted be involved in ... |
33-370 |
4.20e-28 |
|
type 1 periplasmic binding component of active transport systems predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; This group includes the type 1 periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; their substrate specificity is not well characterized, however.
Pssm-ID: 380583 [Multi-domain] Cd Length: 357 Bit Score: 112.77 E-value: 4.20e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 33 PLTGPQAVSGKDDENGLRLAVETLNRTpitVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDRQPAAFF-GPENSGVAIPV 111
Cdd:cd06360 7 PLTGPLAVNGEDVRDGFELYFDEIGNQ---VAGRKIE--LIVEDDEGKPDVGLTKARKLVERDKVHVLaGIVSSAVAYAV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 112 ARLTNAARVP-MLTVASNPQLT-ALGYDNVFRTGASDSVLGASMAAFAAGKLGAKTAAVIDDRTAYGQGLAEQFIAKAKS 189
Cdd:cd06360 82 RDYVVEQKIPlVISNAGAAPLTqELASPYIFRTSFSNGQYDAPFGQYAYEKLGYRRIAVMASDYAAGHEQAGAFARTFKQ 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 190 LGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRAR--LLG-GDGICSANMGTVAQTA- 265
Cdd:cd06360 162 AGGKVVQEIYPPLGTADFAPYLARIQQDAADAVWAFFAGADAIRFVKQYDEYGLKGKlpLVGiGGLVDDAILPEQGDAAl 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 266 ---SRNVYCAmsgsGLDRTEaGRDYVARYRARFKSEPQTYGITYYDGMLLLAKTMAA--AQTTDPAKLIQALRSASHEGV 340
Cdd:cd06360 242 givSYLHYSA----ALDTPE-NKAFVQAYRKKYGRDPGLYAEGGYVAARAIAEALEAvkGNVEDKEAFLEALRKVRFEAP 316
|
330 340 350
....*....|....*....|....*....|....
gi 737992313 341 AGTYAFTVRGelmNAPTTVFTFE----DGQMVPV 370
Cdd:cd06360 317 RGPFRFDPYQ---QAVVTTYIRRvekvDGKLVNV 347
|
|
| PBP1_Nba-like |
cd06359 |
type 1 periplasmic binding component of active transport systems predicted to be involved in ... |
28-346 |
6.52e-28 |
|
type 1 periplasmic binding component of active transport systems predicted to be involved in 2-nitrobenzoic acid degradation pathway; This group includes the type 1 periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; their substrate specificities are not well characterized.
Pssm-ID: 380582 [Multi-domain] Cd Length: 333 Bit Score: 111.58 E-value: 6.52e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 28 IAFSGPLTGPQAVSGKDDENGLRLAVETLNRtpiTVDGQPVrfRIVAEDDQADPRTGVQVAQRLLDRQPAAFF-GPENSG 106
Cdd:cd06359 2 IGFITTLSGPAAVLGQDMRDGFNLALEQLGG---KLGGLPV--EVVVEDDQLKPDVAKQAAERLIERDKVDFVtGIIFSN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 107 VAIPVARLTNAARVPMLTVASNPQLTA--LGYDNVFRTGASDSVLGASMAAFAAGKlGAKTAAVIDDRTAYGQGLAEQFI 184
Cdd:cd06359 77 VMLAVVKPVVDSKVFYISANAGPSDLAgkGCNPNFFVTSWQNDQLHEAAGKYANDK-GYKRVYLLAPNYQAGKDALAGFK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 185 AKAKSlglQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRAR--LLGGDGICSANMGTVA 262
Cdd:cd06359 156 RTYKG---EVVGEIYTPLGQLDFSAELAQIRAAKPDAVFAFYPGGMGVNFVKQYAQAGLKKKipLYTVGTLDDEDLLPAM 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 263 QTASRNVYCAMS-GSGLDrTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLAKTMAAAQ--TTDPAKLIQALRSASHEG 339
Cdd:cd06359 233 GDAALGVLSVSQwSPDLD-NPENKRFVAAFRKKYGRPPSNYAAQGYDAALLIDAAVKAVGgdLSDKDALRAALRKADFKS 311
|
....*..
gi 737992313 340 VAGTYAF 346
Cdd:cd06359 312 VRGAFRF 318
|
|
| PBP1_SBP-like |
cd06328 |
periplasmic substrate-binding domain of active transport proteins (substrate binding proteins ... |
28-351 |
8.92e-27 |
|
periplasmic substrate-binding domain of active transport proteins (substrate binding proteins or SBPs); Periplasmic substrate-binding domain of active transport proteins found in gram-negative and gram-positive bacteria. Members of this group are initial receptors in the process of active transport across cellular membrane, but their substrate specificities are not known in detail. However, they closely resemble the group of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus it may also be involved in transport of amino acids.
Pssm-ID: 380551 [Multi-domain] Cd Length: 336 Bit Score: 108.54 E-value: 8.92e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 28 IAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPITVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDRQPAAFF-GPENSG 106
Cdd:cd06328 2 IGVITSLTGPLAAYGKQTERGFELGLEYATDGTMEVDGRKIE--VIVKDDQGDPDTAKAAATELIGDDGVDILvGTVSSA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 107 VAIPVARLTNAARVPML-TVASNPQLTALGYD-NVFRTGaSDSVLGASMAAFAAGKLGAKTAAVIDDRTAYGQGLAEQFI 184
Cdd:cd06328 80 VALALAPVAEQNKKILIvGPAAADSITGENWNkYTFRTS-RNSWQDAIAGAKALADPLGKSVAFLAQDYAFGQDGVAAFK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 185 AKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLGGDGIcsANMGTVAQ- 263
Cdd:cd06328 159 KALEAKGGKIVGEELVPVTTTDFTPYLQRILDAKPDVLFVAWAGTGALTLWQQLADQGVLDDIKVVTGG--PDIATLAAl 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 264 -TASRNVYCAMS-GSGLDRTEAGRDYVARYRARFKSEPQtygityydgmLLLAKTMAAAQ-----------TTDPAKLIQ 330
Cdd:cd06328 237 gDALPGIEGLTYyYYGLPKNPVNDWLVKAHKERYNAPPD----------LFTAGGFAAAQavvralekaggDTDVEKLIA 306
|
330 340
....*....|....*....|.
gi 737992313 331 ALRSASHEGVAGTYafTVRGE 351
Cdd:cd06328 307 ALEGLTFETPKGKM--TIRAE 325
|
|
| PBP1_SBP-like |
cd06329 |
periplasmic substrate-binding domain of active transport proteins (substrate binding proteins ... |
28-351 |
1.82e-23 |
|
periplasmic substrate-binding domain of active transport proteins (substrate binding proteins or SBPs); Periplasmic substrate-binding domain of active transport proteins found in bacteria and Archaea. Members of this group are initial receptors in the process of active transport across cellular membrane, but their substrate specificities are not known in detail. However, they closely resemble the group of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus it may also be involved in transport of amino acids.
Pssm-ID: 380552 [Multi-domain] Cd Length: 343 Bit Score: 99.66 E-value: 1.82e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 28 IAFSGPLTGPQAVSGKDDENGLRLAVETLNRTpitVDGQPVRFRIVAEDDQADPRTGVQVAQRLLDRQPAAFFGPENSGV 107
Cdd:cd06329 2 IAFIDPLSGPFASVGEIYLKGLQFAIEEINAG---GGLLGRKIELVPFDNKGSPQEALIQLKKAIDQGIRFVLQGNSSAV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 108 AIPVARLTNA-------ARVPMLTVAS-NPQLTAlgyDNV----FRTGASDSVLGASMAAFAAGKLGAKTAAVIDDRTAY 175
Cdd:cd06329 79 AGALIDAIEKhnqrnpdKRVLFLNYGAeAPELTG---AKCsfwhFRFDANADMKMAALADYMKKDGSIKKVYLINQDYSF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 176 GQGLAEQFIA--KAKSLGLQVVAREFtH--SQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLGGD 251
Cdd:cd06329 156 GRDVAAAAKKnlKKKRPDIEIVGEDL-HplGKVKDFSPYIAKIKASGADTVITGNWGNDLTLLMKAARDSGLKAPFYTYY 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 252 GICSANMGTVAQTASRNVYCAMSGSGLDRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLAKTMAAAQTTDPAKLIQA 331
Cdd:cd06329 235 ADGPGAPAAIGEAGVGRLVAVAYWHPNPKTPELEKFAEAFRAKYGRYPDFNIGRTYMGVEMLAAAIKKAGSTDPEKVAKA 314
|
330 340
....*....|....*....|
gi 737992313 332 LRSASHEGVAGTYafTVRGE 351
Cdd:cd06329 315 LEGLSFDTPGGPV--TMRAD 332
|
|
| ANF_receptor |
pfam01094 |
Receptor family ligand binding region; This family includes extracellular ligand binding ... |
46-355 |
2.81e-22 |
|
Receptor family ligand binding region; This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.
Pssm-ID: 460062 [Multi-domain] Cd Length: 347 Bit Score: 96.30 E-value: 2.81e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 46 ENGLRLAVETLNRTPiTVDGQpVRFRIVAEDDQADPRTGVQVAQRLLDRQPAAFFGPENSGVAIPVARLTNAARVPMLTV 125
Cdd:pfam01094 3 LLAVRLAVEDINADP-GLLPG-TKLEYIILDTCCDPSLALAAALDLLKGEVVAIIGPSCSSVASAVASLANEWKVPLISY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 126 AS-NPQLTALG-YDNVFRTGASDSVLGASMAAFAAgKLGAKTAAVIDDRTAYGQGLAEQFIAKAKSLGLQVVAREFT--H 201
Cdd:pfam01094 81 GStSPALSDLNrYPTFLRTTPSDTSQADAIVDILK-HFGWKRVALIYSDDDYGESGLQALEDALRERGIRVAYKAVIppA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 202 SQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGV---RARLLGGDGicSANMGTVAQTASRNVYCAMSG-SG 277
Cdd:pfam01094 160 QDDDEIARKLLKEVKSRARVIVVCCSSETARRLLKAARELGMmgeGYVWIATDG--LTTSLVILNPSTLEAAGGVLGfRL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 278 LDRTEAG-RDYVARYRARFKS-------EPQTYGITYYDGMLLLAKTMAAAQTTDP--------------AKLIQALRSA 335
Cdd:pfam01094 238 HPPDSPEfSEFFWEKLSDEKElyenlggLPVSYGALAYDAVYLLAHALHNLLRDDKpgracgalgpwnggQKLLRYLKNV 317
|
330 340
....*....|....*....|
gi 737992313 336 SHEGVAGTYAFTVRGELMNA 355
Cdd:pfam01094 318 NFTGLTGNVQFDENGDRINP 337
|
|
| PBP1_ABC_ligand_binding-like |
cd06326 |
periplasmic ligand-binding domain of uncharacterized ABC-type transport systems predicted to ... |
26-249 |
7.84e-22 |
|
periplasmic ligand-binding domain of uncharacterized ABC-type transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This group includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); its ligand specificity has not been determined experimentally, however.
Pssm-ID: 380549 [Multi-domain] Cd Length: 339 Bit Score: 94.92 E-value: 7.84e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 26 VTIAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPiTVDGQPVRFriVAEDDQADPRTGVQVAQRLLDR-QPAAFFGPEN 104
Cdd:cd06326 1 IVIGQSAPLSGPLAELGREYLAGAKAYFDQVNAAG-GINGRKIRL--VTLDDGYDPARTVENTRQLIEQdKVVALFGYVG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 105 SGVAIPVARLTNAARVPMLTVAS-NPQLTALGYDNVFRTGASDSVLGASMAAFAAGkLGAKTAAVIDDRTAYGQGLAEQF 183
Cdd:cd06326 78 TANVEAVLPLLEEAGVPLVGPLTgADSLREPGNPYVFHVRASYADEVEKIVRHLAT-LGLKRIAVVYQDDPFGKEGLAAA 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 737992313 184 IAKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLG 249
Cdd:cd06326 157 EAALAARGLEPVATAAVARNAADVAAAAAALAAAKPQAVVLIAAGKAAAAFIKALRAAGGAAQFYG 222
|
|
| PBP1_ABC_ligand_binding-like |
cd19979 |
amino acid amide ABC transporter substrate binding protein haat family; This subgroup includes ... |
34-347 |
8.93e-22 |
|
amino acid amide ABC transporter substrate binding protein haat family; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters, such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.
Pssm-ID: 380634 [Multi-domain] Cd Length: 350 Bit Score: 94.99 E-value: 8.93e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 34 LTGPQAVSGKDDENGLRLAVETLNRTPItVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDR-QPAAFFGPENSGVAIPVA 112
Cdd:cd19979 8 LSGGSAASGEAIKRGIQLAIDEINAAGG-LLGRKLE--LVAKDHRGNPARGVDNLREFAADpDVLAVFGGLHSPVLLAEL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 113 RLTNAARVPMLTV-ASNPQLTALGYDN--VFRTGASDSVLGASMAAFAAGKlGAKTAAVIDDRTAYGQGlAEQFIAKA-K 188
Cdd:cd19979 85 DFIHELKIPYLVPwAAATPITRNGYSPnyIFRLSVDDSLAGPFLVEYALKK-GCKRPALLLENTGWGRS-NLKAMTKAlA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 189 SLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLGGDGICSANMGTVAQTASR- 267
Cdd:cd19979 163 KKGLQPVGVEWFNWGDTDAKPQLRALKAAGADAILLVANAPEGAAIVKALAALPERLPIISHWGITGGDFPELPREALSk 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 268 -NVYCAMSGSGLD--RTEAGRDYVARYRARFKSEPQTYGITY-------YDGMLLLAKTMAAAQTTDPAKLIQAL-RSAS 336
Cdd:cd19979 243 iDLRFIQTFSFFDanQSPRGKQVLARYKRRYPVEDPESDIPApvgfahaYDLTHLLALAIEQAGSTDRAAVRAALeLLPP 322
|
330
....*....|...
gi 737992313 337 HEGVAGTY--AFT 347
Cdd:cd19979 323 HEGLIKTYkpPFT 335
|
|
| PBP1_RPA0985_benzoate-like |
cd20013 |
type 1 periplasmic binding-protein component of an ABC system (RPA0985), involved in the ... |
28-342 |
1.02e-19 |
|
type 1 periplasmic binding-protein component of an ABC system (RPA0985), involved in the active transport of lignin-derived benzoate derivative compounds, and its close homologs; This group includes RPA0985 from Rhodopseudomonas palustris and its close homologs in other bacteria. Rpa0985 is the periplasmic binding-protein component of an ABC system that is involved in the active transport of lignin-derived benzoate derivative compounds. Members of this group has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP).
Pssm-ID: 380666 [Multi-domain] Cd Length: 356 Bit Score: 89.24 E-value: 1.02e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 28 IAFSGPLTGPQAVSGKDDENGLRLAVEtLNRTpiTVDGQPVRFrIVAEDDQADPRTGVQVAQRLLDRQPAAFF-GPENSG 106
Cdd:cd20013 2 VGVIGPFSGPFADYGKQFDRGIDLYLK-LHGD--KVGGRKVEV-IYRDDGGPNPAVAKRLAQELIVRDKVQILiGFGFTP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 107 VAIPVARLTNAARVPM-LTVASNPQLTALGyDNVFRTGASDSVLGASMAAFAAgKLGAKTAAVIDDRTAYGQGLAEQFIA 185
Cdd:cd20013 78 NALAVAPVATEAKTPTvIMNAATSSITRKS-PYFVRTSFTMWQVAYPMGKWAA-KNGIKKAYTAVADYAPGHDAETAFKK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 186 KAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFF---GGytAQAAPMAKQMVQRGVRA---RLLGG----DGICS 255
Cdd:cd20013 156 AFEAAGGKIVGSIRVPLATPDFAPFMQRIKDAKPDAVFVfvpAG--APSIGFLKAYAERGLKEagiKLLGTgdatDDDDL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 256 ANMGtvaqTASRNVYCAMSGSGLDRTEAGRDYVARYRARF--KSEPQTYGITYYDGMLLLAKtMAAAQ--TTDPAKLIQA 331
Cdd:cd20013 234 PAMG----DAALGLITAGHYSAALDSPENKAFVAAYQKAYgpDARPDFMAVAAYDGMALIYK-MIKATggKFDGDKAMAA 308
|
330
....*....|.
gi 737992313 332 LRSASHEGVAG 342
Cdd:cd20013 309 VKGLKWESPRG 319
|
|
| PBP1_SBP-like |
cd20378 |
periplasmic substrate-binding domain of active transport proteins; Periplasmic ... |
33-343 |
1.52e-19 |
|
periplasmic substrate-binding domain of active transport proteins; Periplasmic substrate-binding domain of active transport proteins found in bacteria and Archaea. Members of this group are initial receptors in the process of active transport across cellular membrane, but their substrate specificities are not known in detail. However, they closely resemble the group of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus it may also be involved in transport of amino acids.
Pssm-ID: 380668 [Multi-domain] Cd Length: 357 Bit Score: 88.56 E-value: 1.52e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 33 PLTGPQAVSGKDDENGLRLAVETLNrtpiTVDGQPVRFriVAEDDQADPRTGVQVAQRLLDRQPAAFF-GPENSGVAIPV 111
Cdd:cd20378 7 SMSGAFAAAGKLADRGMRLAVEEYG----GALGRPLKY--ITRDTEGKPGTGVRKVQEAIAQDGARFFiGGTLSSVALAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 112 ARLTNAARVPMLTVASNPQLTalGYD---NVFR-----TGASDSVLGASMAAFAAgklgAKTAAVIDDRTAYGQGLAEQF 183
Cdd:cd20378 81 SEEAEKAGGVYITSGGADEIT--GSRcnrSTFRwsvptYGAIRQTVRPVIKAMPK----AKRWYTITPQYVFGESLLKNA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 184 IAKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGV--RARLLGGDGICSANMGTV 261
Cdd:cd20378 155 KEVLKEKGIEHVGNSYHSLGEREFSGYLTKAMAARPDVLLILNFGSQAVDALRQAVSFGLkrKMKILVAWSSGLDQFQEL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 262 AQTASRNVYC-AMSGSGLDrTEAGRDYVARYRARFKSEPqTYGITY-YDGMLLLAKTMAAAQTTDPAKLIQALRSASHEG 339
Cdd:cd20378 235 GPDICEGVYFgAQYWHDVD-TPANKALVKVYQAKFKETP-SYALAAgYACTRMLLDAIDKAGSTDPAAVIKALEGLKYDG 312
|
....
gi 737992313 340 VAGT 343
Cdd:cd20378 313 ITGD 316
|
|
| PBP1_YraM_LppC_lipoprotein-like |
cd06339 |
periplasmic binding component of lipoprotein LppC, an immunodominant antigen; This subgroup ... |
27-314 |
2.48e-19 |
|
periplasmic binding component of lipoprotein LppC, an immunodominant antigen; This subgroup includes periplasmic binding component of lipoprotein LppC, an immunodominant antigen, whose molecular function is not characterized. Members of this subgroup are predicted to be involved in transport of lipid compounds, and they are sequence similar to the family of ABC-type hydrophobic amino acid transporters (HAAT).
Pssm-ID: 380562 [Multi-domain] Cd Length: 331 Bit Score: 87.71 E-value: 2.48e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 27 TIAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPITVdgqpvRFRivaedDQADPRTGVQVAQRLLDRQPAAFFGPENSG 106
Cdd:cd06339 1 RIALLLPLSGPYAAAGQAIRDGIELALFDAGGSRPEL-----RVY-----DTGGPEGAAAAYQQAVAEGADLIIGPLLKS 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 107 VAIPVARLTNAARVPMLTvASNPQLTALGyDNVFRTGASDSVLGASMAAFAAGKlGAKTAAVIDDRTAYGQGLAEQFIAK 186
Cdd:cd06339 71 SVAALAAAAQALGVPVLA-LNNDESATAG-PGLFQFGLSPEDEARQAARYAVQQ-GLRRFAVLAPDNAYGQRVANAFREA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 187 AKSLGLQVVAREFTHSQATDFLAILATIKG----------------------KNPDVIFFGGYTAQAAPMAKQM-VQRGV 243
Cdd:cd06339 148 WQALGGTVVAVESYDPDETDFSAAIRRLLGvdqsearirqlgellefeprrrQDFDAIFLPAGPEQARLIAPQLaFYGAG 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 737992313 244 RARLLGGDGICSANMGTVAQTASRNV-YCAMsgsglDRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLA 314
Cdd:cd06339 228 DVPLLGTSLWYSGKLNLLRDPDLNGAwFADP-----PWLLSPRAFPLRYRLAYGWPPPRLAALGYDAYRLAA 294
|
|
| PBP1_SBP-like |
cd19987 |
periplasmic substrate-binding domain of active transport proteins; Periplasmic ... |
27-350 |
1.90e-17 |
|
periplasmic substrate-binding domain of active transport proteins; Periplasmic substrate-binding domain of active transport proteins found in bacteria and Archaea. Members of this group are initial receptors in the process of active transport across cellular membrane, but their substrate specificities are not known in detail. However, they closely resemble the group of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus it may also be involved in transport of amino acids.
Pssm-ID: 380642 [Multi-domain] Cd Length: 353 Bit Score: 82.38 E-value: 1.90e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 27 TIAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPITVD-----------GQPVRFriVAEDDQADPRTGVQVAQRLLDRQ 95
Cdd:cd19987 1 TIGLNVPLSGPYAPQGEDQRRGFELAVDHLNNGGGLVDkdsrlsgdgilGKKVEL--VTADTETKADTAVDNAKRLIEQD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 96 PAA-FFGPENSGVAIPVARLTNAARVP-MLTVASNPQLTalGYD---NVFRTGASDSVLGASMAAFAAGKLG-AKTAAVI 169
Cdd:cd19987 79 GAVmITGGSSSAVAVAAQKLAQKEGVLyFAGLSHSNDTT--GKDchrYGFRECFNAHMSAKALAPYLVEKFGkDRKYFYL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 170 DDRTAYGQGLAEQFIAKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLlg 249
Cdd:cd19987 157 TADYTWGHSTEQSMREYTEAHGWKTVGNPATPLGETDFSAALLNAADSGADVLVLVLFGRDMVNALKQAKQFGLLKKM-- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 250 gdGICSANMG-----TVAQTASRNVYCAMS--GSGLDRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLAKTMAAAQT 322
Cdd:cd19987 235 --DIVVPLLTafmaeSVGPEIMEGVLGTVNwhWSLPDDYSYAFGKAEAFEKEYGAYPSQAAASAYVQVLQYAAAVERAGS 312
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 737992313 323 TDPAKLIQAL--------------RSASHEGVAGTYafTVRG 350
Cdd:cd19987 313 FDPPAVIRALegheytllkgeqywRACDHQSVRPVY--VVRG 352
|
|
| PBP1_ABC_ligand_binding-like |
cd06334 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
27-249 |
8.64e-16 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters, such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.
Pssm-ID: 380557 [Multi-domain] Cd Length: 360 Bit Score: 77.67 E-value: 8.64e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 27 TIAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPItVDGqpVRFRIVAEDDQADPRTGVQVAQRLLDRQPAAFFGPENSG 106
Cdd:cd06334 1 KIGLLTDLTGPTADVGKPYAQGVRDYLNYVNEEGG-ING--VKIELEECDTGYKVPRAVACYKRLKAQDGVVAILGWGTG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 107 VAIPVARLTNAARVPMLTVASNPQLTALG--YDNVFRTGASDSVLGASMAAFAA----GKLGAKTAAVIDDRTAYGQGLA 180
Cdd:cd06334 78 DTEALAPRVAKDKIPYISASYGRSLADDGkvFPYNFFVGATYSSQARALLKYIAqewgGKLKGPKVAFVYHDSPFGREPI 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 737992313 181 EQFIAKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLG 249
Cdd:cd06334 158 PALKAYAKELGFEVVAEQVPSPGALDATAQWLRIRRAGPDYVIIQGTGGSVAVIIKDAKRLGLKTKFIG 226
|
|
| PBP1_ABC_ligand_binding-like |
cd06341 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
63-348 |
8.28e-14 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.
Pssm-ID: 380564 [Multi-domain] Cd Length: 340 Bit Score: 71.57 E-value: 8.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 63 VDGQPVRfrIVAEDDQADPRTGVQVAQRLLDRQPAAFFGPENSGVAIPVARLTNAARVPMLTVAS-NPQLTALGYDNVFR 141
Cdd:cd06341 36 INGRKVE--YVWCDDQSDPATNLQAARQLVEDEKVFALVGSSSAASGSANDYLAQAGIPVVGGAGvSVWCFRNMFSNFFS 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 142 TGASDSVLgaSMAAFAAGKLGAKTAAVIDDRTAYGQGLAEQFIAKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDV 221
Cdd:cd06341 114 LGGGGSTT--TYGQYAAALGGTKAAVVVTDIPAASQQLAQQLAASLRAAGVEVVGTAPYAAAAPDYTAVAQAAKAAGADA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 222 IFFGGYTAQAAPMAKQMVQRGVRARL-LGGDGICSANMGTVAQTASRNVYCAMSGSGLDRTEAGRDY---VARYRARFKS 297
Cdd:cd06341 192 VVGVLDPDVAARVLKAARAQGLDLKVaLSPSGYDPSVLAAYGAALAGVSVASTFLPFEADTPAVKAYraaMAKYAPELQD 271
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 737992313 298 EPQTYGI-TYYDGMLLLAKTMAAAQTTDPAKLIQALRSASHEGVAGTYAFTV 348
Cdd:cd06341 272 PLQQFALsGYIAADLFVRGLEAAGGCPTRAAFIKALRDVKDYDAGGLLPPGD 323
|
|
| PBP1_AmiC |
cd06357 |
periplasmic binding domain of amidase (AmiC) that belongs to the type 1 periplasmic binding ... |
26-343 |
6.44e-13 |
|
periplasmic binding domain of amidase (AmiC) that belongs to the type 1 periplasmic binding fold protein family; This group includes the periplasmic binding domain of amidase (AmiC) that belongs to the type 1 periplasmic binding fold protein family. AmiC controls expression of the amidase operon by the ligand-triggered conformational switch. In the absence of ligand or presence of butyramide (repressor), AmiC (the ligand sensor and negative regulator) adopts an open conformation and inhibits the transcription antitermination function of AmiR by direct protein-protein interaction. In the presence of inducing ligands such as acetamide, AmiC adopts a closed conformation which disrupts a silencing AmiC-AmiR complex and the expression of amidase and other genes of the operon are induced.
Pssm-ID: 380580 [Multi-domain] Cd Length: 357 Bit Score: 69.14 E-value: 6.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 26 VTIAFSgpLTGPQAVSGKDDENGLRLAVETLNRTPiTVDGQPvrFRIVAEDDQADPRTGVQVAQRLLDRqpaaffgpenS 105
Cdd:cd06357 2 VGLLFS--QTGVTAIIEQSMLNGALLAIEEINAAG-GVNGRP--IEPVVYDPASDPDRYRELAERLLLE----------D 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 106 GVAIPVARLTNAARVPML-TVASNPQLtaLGY----------DNVFRTGASDSVLGASMAAFAAGKLGAKtAAVIDDRTA 174
Cdd:cd06357 67 GVRHIFGCYTSASRKAVLpVVERHNAL--LWYptpyegfeysPNVIYTGAVPNQHLLPLARYLLAHFGKR-VFLVGSNYV 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 175 YGQ---GLAEQFIAKAkslGLQVVAREFTHSQATDFLAILATIKGKNPDVIFfggytaqaapmaKQMVQRGVRA--RLLG 249
Cdd:cd06357 144 YPWesnRVARELIEAS---GGEVVGERYVPLGDTDFAEIIEEIKSLKPDVVF------------STLVGDSIYAfyRAYA 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 250 GDGICSANMGTVAQTASRNVYCAMSGSGLDR------------TEAGRDYVARYRARFKSEPQTYGI--TYYDGMLLLAK 315
Cdd:cd06357 209 EAGLDPADMPIASLTTSEAEVAAIGAEAAAGhytsapyfqsidTPENRAFVEAYRARFGDDAVTSAVaeAAYFQVHLLAR 288
|
330 340
....*....|....*....|....*...
gi 737992313 316 TMAAAQTTDPAKLIQALRSASHEGVAGT 343
Cdd:cd06357 289 AIERAGSDDPEAIRAALYGQEFDAPQGP 316
|
|
| PBP1_amide_urea_BP-like |
cd06356 |
periplasmic component (FmdD) of an active transport system for short-chain amides and urea ... |
34-343 |
6.71e-13 |
|
periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); This group includes the type 1 periplasmic-binding proteins that are predicted to have a function similar to that of an active transport system for short chain amides and/or urea in bacteria and Archaea, by sequence comparison and phylogenetic analysis.
Pssm-ID: 380579 [Multi-domain] Cd Length: 334 Bit Score: 68.87 E-value: 6.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 34 LTGPQAVSGKDDENGLRLAVETLNRTPiTVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDRQpaaffgpensGVAIPVAR 113
Cdd:cd06356 8 LSGGLNIYGKPMVHAMKLAVEEINAAG-GLLGRQIE--LVAYDTQSDMQKYTQYAQQLILRD----------KVDVVFGG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 114 LTNAARV---PMLTVASNPQLTALGYD------NVFRTGASDSVLGASMAAFAAGKLGAKTAAVIDDRTaYGQGLAEQFI 184
Cdd:cd06356 75 ITSASREairPILRRNKILYFYNTQYEggvcdkNTFCTGSTPEQQVSPLIEWAIKKYGKKVYIIAADYN-FGQISADWVK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 185 AKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVI---FFGG-----YTAQAApmakqmvqrgvrARLLGGDGICSA 256
Cdd:cd06356 154 KYAKKNGGEVVGEEFFPLDVTDFGPTIQKIQAAKPDFVvslLVGGnhisfYRQWAA------------AGLKKKIPIVST 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 257 NMGT------VAQTASRNVYCAMSG-SGLDrTEAGRDYVARYRARFKSEP--QTYGITYYDGMLLLAKTMAAAQTTDPAK 327
Cdd:cd06356 222 VFGAgnehkvLSPPELEGMYVSYSYfEELD-TPANKAFVAKWRAKYGDEPyiNQEAVGVYNAVYLWAEAVEKAGSTEREA 300
|
330
....*....|....*..
gi 737992313 328 LIQALRSA-SHEGVAGT 343
Cdd:cd06356 301 VIAALESGiSFDGPSGT 317
|
|
| PBP1_glutamate_receptors-like |
cd06269 |
ligand-binding domain of family C G-protein couples receptors (GPCRs), membrane bound guanylyl ... |
41-251 |
1.28e-12 |
|
ligand-binding domain of family C G-protein couples receptors (GPCRs), membrane bound guanylyl cyclases such as natriuretic peptide receptors (NPRs), and N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of ionotropic glutamate rece; This CD represents the ligand-binding domain of the family C G-protein couples receptors (GPCRs), membrane bound guanylyl cyclases such as the family of natriuretic peptide receptors (NPRs), and the N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the ionotropic glutamate receptors, all of which are structurally similar and related to the periplasmic-binding fold type 1 family. The family C GPCRs consists of metabotropic glutamate receptor (mGluR), a calcium-sensing receptor (CaSR), gamma-aminobutyric acid receptor (GABAbR), the promiscuous L-alpha-amino acid receptor GPR6A, families of taste and pheromone receptors, and orphan receptors. Truncated splicing variants of the orphan receptors are not included in this CD. The family C GPCRs are activated by endogenous agonists such as amino acids, ions, and sugar based molecules. Their amino terminal ligand-binding region is homologous to the bacterial leucine-isoleucine-valine binding protein (LIVBP) and a leucine binding protein (LBP). The ionotropic glutamate receptors (iGluRs) have an integral ion channel and are subdivided into three major groups based on their pharmacology and structural similarities: NMDA receptors, AMPA receptors, and kainate receptors. The family of membrane bound guanylyl cyclases is further divided into three subfamilies: the ANP receptor (GC-A)/C-type natriuretic peptide receptor (GC-B), the heat-stable enterotoxin receptor (GC-C)/sensory organ specific membrane GCs such as retinal receptors (GC-E, GC-F), and olfactory receptors (GC-D and GC-G).
Pssm-ID: 380493 [Multi-domain] Cd Length: 332 Bit Score: 67.83 E-value: 1.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 41 SGKDDENGLRLAVETLNRTPitVDGQPVRFRIVAEDDQADPrtgVQVAQRLLD----RQPAAFFGPENSGVAIPVARLTN 116
Cdd:cd06269 14 SGAKVLPAFELALSDVNSRP--DLLPKTTLGLAIRDSECNP---TQALLSACDllaaAKVVAILGPGCSASAAPVANLAR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 117 AARVPMLTVASNPQLTA--LGYDNVFRTGASDSVLGASMAAFAAgKLGAKTAAVIDDRTAYGQGLAEQFIAKAKSLGLQV 194
Cdd:cd06269 89 HWDIPVLSYGATAPGLSdkSRYAYFLRTVPPDSKQADAMLALVR-RLGWNKVVLIYSDDEYGEFGLEGLEELFQEKGGLI 167
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 737992313 195 VAR-EFTHSQATDFLAILATIKGKNPDVIFFggytaQAAPM-AKQMVQRGVRARLLGGD 251
Cdd:cd06269 168 TSRqSFDENKDDDLTKLLRNLRDTEARVIIL-----LASPDtARSLMLEAKRLDMTSKD 221
|
|
| PBP1_SBP-like |
cd06327 |
periplasmic substrate-binding domain of active transport proteins (substrate binding proteins ... |
30-333 |
5.85e-12 |
|
periplasmic substrate-binding domain of active transport proteins (substrate binding proteins or SBPs); Periplasmic substrate-binding domain of active transport proteins found in gram-negative, gram-positive bacteria, and archaea. Members of this group are initial receptors in the process of active transport across cellular membrane, but their substrate specificities are not known in detail. However, they closely resemble the group of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus it may also be involved in transport of amino acids.
Pssm-ID: 380550 [Multi-domain] Cd Length: 336 Bit Score: 66.06 E-value: 5.85e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 30 FSGPLtgpQAVSGKDDENGLRLAVETLNRTpitVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDRQPA-AFFGPENSGVA 108
Cdd:cd06327 8 LSGVY---ADLSGPGSVEAAKMAVEDFGGK---VLGRPIE--VVSADHQNKPDVASAIAREWYDRDGVdAIVDVPNSAVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 109 IPVARLTNAA-RVPMLTVASNPQLT-----ALGYDNVFRTGASDSVLGAsmaafAAGKLGAKTAAVIDDRTAYGQGLAEQ 182
Cdd:cd06327 80 LAVQKLAKEKkKIAIVTGAGSSDLTgkacsPYGVHWAYDTYALARGTVK-----ALVKQGGKSWFFITADYAFGHSLEAD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 183 FIAKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRArllggdgicsANMGTVA 262
Cdd:cd06327 155 ATAAVKAAGGKVVGSVRHPLGTTDFSSFLLQAQASGADVIALANAGADLVNAVKQAREFGLTD----------GGQKLAA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 263 QTASRNVYCAM---SGSGL--------DRTEAGRDYVARYRARFKSEPQTYGITYYDGMLLLAKTMAAAQTTDPAKLIQA 331
Cdd:cd06327 225 LLLFITDIHALgldAAQGLylttafywDRDDATRAWAKRFFARTGKMPTMLQAGVYSAVLHYLKAVKAAGTDDADAVVAK 304
|
..
gi 737992313 332 LR 333
Cdd:cd06327 305 MR 306
|
|
| PBP1_FmdD-like |
cd06355 |
periplasmic component (FmdD) of an active transport system for short-chain amides and urea ... |
34-367 |
1.32e-11 |
|
periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); This group includes the periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF), found in Methylophilus methylotrophus, and its homologs from other bacteria. FmdD, a type 1 periplasmic binding protein, is induced by short-chain amides and urea and repressed by excess ammonia, while FmdE and FmdF are hydrophobic transmembrane proteins. FmdDEF is predicted to be an ATP-dependent transporter and closely resembles the periplasmic binding protein and the two transmembrane proteins present in various hydrophobic amino acid-binding transport systems.
Pssm-ID: 380578 [Multi-domain] Cd Length: 347 Bit Score: 64.90 E-value: 1.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 34 LTGPQAVSGKDDENGLRLAVETLNRTPItVDGQPVRfrIVAEDDQADPRTGVQVAQRLL-DRQPAAFFGPensgvaipva 112
Cdd:cd06355 8 LSGTMAISERPLVDATLLAIDEINAAGG-LLGRKIE--PVIEDGASDWPTFAEKAEKLItQDKVAVIFGC---------- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 113 rLTNAARVPMLTV--ASNPQL-TALGYD------NVFRTGAS--DSVLGAsmAAFAAGKLGAKTAAVIDD----RTAygq 177
Cdd:cd06355 75 -WTSASRKAVLPVieKYNGLLfYPVQYEgleqspNIVYTGATpnQQILPA--IDWLLENLGKRFFLVGSDyvfpRTA--- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 178 glaeQFIAKA--KSLGLQVVAREFTHSQATDFLAILATIKGKNPDVI-----------FFggytaqaapmaKQMVQRGVR 244
Cdd:cd06355 149 ----NKIIRDqlKALGGEVVGEEYVPLGGTDFDAIVAKIKAFKPDVIvntlngdsniaFF-----------KQLAAAGIT 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 245 ARLLggdGICSANMG--TVAQTASRNV---YCAMSGSGLDRTEAGRDYVARYRARFKSEPQTY--GITYYDGMLLLAKTM 317
Cdd:cd06355 214 ASDL---PVLSFSVSeaELRAIGPEELaghYAAWNYFQSLDTPENQAFVEAFKAKYGADRVTSdpMEAAYLGVYLWAQAV 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 737992313 318 AAAQTTDPAKLIQALRSASHEGVAGTYafTVRGELMNAPTTVFTFE---DGQM 367
Cdd:cd06355 291 EKAGSFDPDAVRAALKGQSFEAPGGTV--TVDPENHHLWKPVRIGKvqaDGQF 341
|
|
| PBP1_ABC_transporter_GPCR_C-like |
cd04509 |
Family C of G-protein coupled receptors and their close homologs, the type 1 ... |
33-255 |
2.96e-11 |
|
Family C of G-protein coupled receptors and their close homologs, the type 1 periplasmic-binding proteins of ATP-binding cassette transporter-like systems; This CD includes members of the family C of G-protein coupled receptors and their close homologs, the type 1 periplasmic-binding proteins of ATP-binding cassette transporter-like systems. The family C GPCR includes glutamate/glycine-gated ion channels such as the NMDA receptor, G-protein-coupled receptors, metabotropic glutamate, GABA-B, calcium sensing, pheromone receptors, and atrial natriuretic peptide-guanylate cyclase receptors. The glutamate receptors that form cation-selective ion channels, iGluR, can be classified into three different subgroups according to their binding-affinity for the agonists NMDA (N-methyl-D-asparate), AMPA (alpha-amino-3-dihydro-5-methyl-3-oxo-4-isoxazolepropionic acid), and kainate. L-glutamate is a major neurotransmitter in the brain of vertebrates and acts through either mGluRs or iGluRs. mGluRs subunits possess seven transmembrane segments and a large N-terminal extracellular domain. ABC-type leucine-isoleucine-valine binding protein (LIVBP) is a bacterial periplasmic binding protein that has homology with the amino-terminal domain of the glutamate-receptor ion channels (iGluRs). The extracellular regions of iGluRs are made of two PBP-like domains in tandem, a LIVBP-like domain that constitutes the N terminus (included in this model) followed by a domain related to lysine-arginine-ornithine-binding protein (LAOBP) that belongs to the type 2 periplasmic binding fold protein superfamily. The uncharacterized periplasmic components of various ABC-type transport systems are also included in this family.
Pssm-ID: 380490 Cd Length: 306 Bit Score: 63.86 E-value: 2.96e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 33 PLTGPQAVSGKDDENGLRLAVETLNRTPITVDGqpVRFRIVAEDDQADPRTGVQVA--------------QRLLDRQPAA 98
Cdd:cd04509 17 PCGDIVAQYGIQRFEAMEQALDDINADPNLLPN--NTLGIVIYDDCCDPKQALEQSnkfvndliqkdtsdVRCTNGEPPV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 99 F---------FGPENSGVAIPVARLTNAARVPMLTVASN-PQLTAL-GYDNVFRTGASDSVLGASMAAFAAgKLGAKTAA 167
Cdd:cd04509 95 FvkpegikgvIGHLCSSVTIPVSNILELFGIPQITYAATaPELSDDrGYQLFLRVVPLDSDQAPAMADIVK-EKVWQYVS 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 168 VIDDRTAYGQGLAEQFIAKAKSLGLQVV--AREFTHSQATDFLAILATIKGKNP-DVIFFGGYTAQAAPMAKQMVQRGVR 244
Cdd:cd04509 174 IVHDEGQYGEGGARAFQDGLKKGGLCIAfsDGITAGEKTKDFDRLVARLKKENNiRFVVYFGYHPEMGQILRAARRAGLV 253
|
250
....*....|...
gi 737992313 245 AR--LLGGDGICS 255
Cdd:cd04509 254 GKfqFMGSDGWAN 266
|
|
| PBP1_NHase |
cd06358 |
type 1 periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively ... |
28-350 |
3.12e-11 |
|
type 1 periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; This group includes the type 1 periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides, which are subsequently converted by amidases to yield free carboxylic acids and ammonia. NHases from bacteria and fungi have been purified and characterized. In Rhodococcus sp., the nitrile hydratase operon consists of six genes encoding NHase regulator 2, NHase regulator 1, amidase, NHase alpha subunit, NHase beta subunit, and NHase activator. The operon produces a constitutive hydratase that has a broad substrate spectrum: aliphatic and aromatic nitriles, mononitriles and dinitriles, hydroxynitriles and amino-nitriles, and a constitutive amidase of equally low substrate specificity. NHases are metalloenzymes containing either cobalt or iron, and therefore can be classified into two subgroups: ferric NHases and cobalt NHases.
Pssm-ID: 380581 [Multi-domain] Cd Length: 333 Bit Score: 63.76 E-value: 3.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 28 IAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPiTVDGQPVRfrIVAEDDQADPRTGVQVAQRLLDRQPA-AFFGPENSG 106
Cdd:cd06358 2 IGLLIPLSGPAGLWGPSCEACAELAAAEINAAG-GILGREVE--LVLIDAGGPPAEVAAAARRLVDDGAVdAIVGMHTSA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 107 VAIPVARLTnAARVPMLtvasnpqLTAL-----GYDNVFRTGASDS-VLGASMAAFAAgKLGAKTAAVI-DD----RTAY 175
Cdd:cd06358 79 VRQALANAV-GGRVPYV-------YTPLyeggeRTPGVYAIGETPEeQLRPALRWLAD-ERRVRRWFLVgNDyvwpRASH 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 176 GqgLAEQFIAkakSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLGGDGICS 255
Cdd:cd06358 150 A--AARRYIA---RLGGEVVGERFVPLGEDDFERVLARIRASRPDAVLISLVGQDAVDFNRAFAAAGLAGRILRLSPAID 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 256 ANMGT-VAQTASRNVYCAMSGSGLDRTEAGRDYVARYRARFKSE---PQTYGITYYDGMLLLAKTMAAAQTTDPAKLIQA 331
Cdd:cd06358 225 ENVLLaIGADATENLYSASGYFASLRTAANLAFLERYHAAFGDRappLNALGESCYEGVHFLAALARRAGSLDVRALAAA 304
|
330
....*....|....*....
gi 737992313 332 LRSASHEGVAGTYAFTVRG 350
Cdd:cd06358 305 AEGLTYESPRGAVTLRGRH 323
|
|
| PBP1_ABC_ligand_binding-like |
cd19978 |
periplasmic ligand-binding domain of uncharacterized ABC-type transport systems predicted to ... |
26-249 |
3.34e-10 |
|
periplasmic ligand-binding domain of uncharacterized ABC-type transport systems predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; This group includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); its ligand specificity has not been determined experimentally, however.
Pssm-ID: 380633 [Multi-domain] Cd Length: 341 Bit Score: 60.67 E-value: 3.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 26 VTIAFSGPLTGPQAVSGKDDENGLRLAVETLNRTpitvDGQPVRF-RIVAEDDQADPRTGVQVAQRLLDRQPA-AFFGPE 103
Cdd:cd19978 1 IRLGMSAALSGPAAELGNEMKRGIEAAFNEVNAQ----GGVNGRKiKLIALDDGYEPDRTVKNTKKLIEEDKVfALIGYV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 104 NSGVAIPVARLTNAARVPMLTVASN-PQLTALGYDNVF--RTGASDSVlgASMAAFAAGKLGAKTAAVI--DDrtAYGQG 178
Cdd:cd19978 77 GTPTALAALPLANEKKIPLFGPFTGaEFLRTPFLPYVFnlRASYADET--EALVDYLVKTLGPKRIAIFyqND--AFGLA 152
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 737992313 179 LAEQFIAKAKSLGLQVVArEFTHSQAT-DFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRARLLG 249
Cdd:cd19978 153 GLEGAKKALKKRGLTPVA-EGSYTRNTlDVEEALAKILKAKPEAIILVGTYAPAAEFIRLARAAGLNPLFAN 223
|
|
| PBP1_ABC_ligand_binding-like |
cd06337 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
27-347 |
3.40e-10 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters, such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.
Pssm-ID: 380560 [Multi-domain] Cd Length: 354 Bit Score: 60.78 E-value: 3.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 27 TIAFSGPLTGPQAVSGKDDENGLRLAVETLNRTPITVDGQPVRFRIVAEDDQADPRTGVQVAQRLLDRQ----PAAFFGP 102
Cdd:cd06337 1 KIGRVSPLTGPLAAFGEADPWVLEQIREAFADGGIKVGGKKYPVEIVVRDSQSDPNRAGEAARDLILRDkvdlMLASGTP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 103 EnsgVAIPVARLTNAARVPMLTVAS--NPQLTALGYDNVFRT--------GASDsVLGASMAAFAAGKLGAKTAAVIDDr 172
Cdd:cd06337 81 D---TVNPVADQCEANGVPCISTDApwQAWFFGRGGDPAKGFkwtfhffwGLED-IAANFLGMWDQVPTNKVVGLLWPN- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 173 TAYGQGLAEQFIAKAKSLGLQVVAREFTHSQATDFLAILATIKGKNPDVIFFGGYTAQAAPMAKQMVQRGVRAR------ 246
Cdd:cd06337 156 DPDGTAFADAFLGLPAAAGYTLVDPGRFPPGTDDFSSIINAFKKAGVEIVTGVMIPPDFATFWRQAAQQGFKPKvvtigk 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 247 ---------LLG--GDGICSANMGTVA-QTASrnvycamSGSGldrtEAGRDYVARYRARFKsEPQTYGITYYDGML-LL 313
Cdd:cd06337 236 allfpsavaALGdlGDGLSTEVWWSPAhPFKS-------SLTG----QTAAELADAYEKATG-KQWTQPLGYAHALFeVA 303
|
330 340 350
....*....|....*....|....*....|....
gi 737992313 314 AKTMAAAQTTDPAKLIQALRSASHEGVAGTYAFT 347
Cdd:cd06337 304 VDALKRAGSPDDEAVRAALADTDLDTIVGPVDFT 337
|
|
| PBP1_GPCR_family_C-like |
cd06350 |
ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory ... |
97-243 |
3.59e-09 |
|
ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate; categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (m; Ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate and are categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). The metabotropic glutamate receptors (mGluR) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. The mGluRs are coupled to G proteins and are thus distinct from the iGluRs which internally contain ligand-gated ion channels. The mGluR structure is divided into three regions: the extracellular region, the seven-spanning transmembrane region and the cytoplasmic region. The extracellular region is further divided into the ligand-binding domain (LBD) and the cysteine-rich domain. The LBD has sequence similarity to the LIVBP, which is a bacterial periplasmic protein (PBP), as well as to the extracellular region of both iGluR and the gamma-aminobutyric acid (GABA)b receptor. iGluRs are divided into three main subtypes based on pharmacological profile: NMDA, AMPA, and kainate receptors. All family C GPCRs have a large extracellular N terminus that contain a domain with homology to bacterial periplasmic amino acid-binding proteins.
Pssm-ID: 380573 Cd Length: 350 Bit Score: 57.69 E-value: 3.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 97 AAFFGPENSGVAIPVARLTNAARVPMLT-VASNPQLT-ALGYDNVFRTGASDSVLGASMAAFAAgKLGAKTAAVIDDRTA 174
Cdd:cd06350 96 VAVIGAASSSVSIAVANLLGLFKIPQISyASTSPELSdKIRYPYFLRTVPSDTLQAKAIADLLK-HFNWNYVSTVYSDDD 174
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 737992313 175 YGQGLAEQFIAKAKSLGLQV-VAREFTH-SQATDFLAILATIKGK-NPDVIFFGGYTAQAAPMAKQMVQRGV 243
Cdd:cd06350 175 YGRSGIEAFEREAKERGICIaQTIVIPEnSTEDEIKRIIDKLKSSpNAKVVVLFLTESDARELLKEAKRRNL 246
|
|
| PBP1_GABAb_receptor_plant |
cd19990 |
periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close ... |
42-357 |
2.50e-08 |
|
periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close homologs in other plants; This group includes the ligand-binding domain of Arabidopsis thaliana glutamate receptors, which have sequence similarity with animal ionotropic glutamate receptor and its close homologs in other plants. The ligand-binding domain of GABAb receptors are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). GABA is the major inhibitory neurotransmitter in the mammalian CNS and, like glutamate and other transmitters, acts via both ligand gated ion channels (GABAa receptors) and G-protein coupled receptors (GABAb receptor or GABAbR). GABAa receptors are members of the ionotropic receptor superfamily which includes alpha-adrenergic and glycine receptors. The GABAb receptor is a member of a receptor superfamily which includes the mGlu receptors. The GABAb receptor is coupled to G alpha-i proteins, and activation causes a decrease in calcium, an increase in potassium membrane conductance, and inhibition of cAMP formation. The response is thus inhibitory and leads to hyperpolarization and decreased neurotransmitter release, for example.
Pssm-ID: 380645 [Multi-domain] Cd Length: 373 Bit Score: 55.31 E-value: 2.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 42 GKDDENGLRLAVETLNRTPitvDGQPVRFRIVAEDDQADPRTGVQVAQRLL-DRQPAAFFGPENSGVAIPVARLTNAARV 120
Cdd:cd19990 13 GKEAKVAIEMAVSDFNSDS---SSYGTKLVLHVRDSKGDPLQAASAALDLIkNKKVEAIIGPQTSEEASFVAELGNKAQV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 121 PMLTV-ASNPQLTALGYDNVFRTGASDSvlgASMAAFAA--GKLGAKTAAVIDDRTAYGQG----LAEQFIAKAKSLGLQ 193
Cdd:cd19990 90 PIISFsATSPTLSSLRWPFFIRMTHNDS---SQMKAIAAivQSYGWRRVVLIYEDDDYGSGiipyLSDALQEVGSRIEYR 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 194 VVareFTHSQATDFL-AILATIKGKNPDVIFfggyTAQAAPMAKQMVQrgvRARLLG--GDG---ICSANMGTVAQTASR 267
Cdd:cd19990 167 VA---LPPSSPEDSIeEELIKLKSMQSRVFV----VHMSSLLASRLFQ---EAKKLGmmEKGyvwIVTDGITNLLDSLDS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 268 NVYCAMSG-----SGLDRTEAGRDYVARYRARFKSE--------PQTYGITYYDGMLLLAKTMAAAQTTDPA-------- 326
Cdd:cd19990 237 STISSMQGvigikTYIPESSEFQDFKARFRKKFRSEypeeenaePNIYALRAYDAIWALAHAVEKLNSSGGNisvsdsgk 316
|
330 340 350
....*....|....*....|....*....|.
gi 737992313 327 KLIQALRSASHEGVAGTYAFtVRGELMNAPT 357
Cdd:cd19990 317 KLLEEILSTKFKGLSGEVQF-VDGQLAPPPA 346
|
|
| PBP1_GABAb_receptor |
cd06366 |
ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for ... |
33-370 |
2.94e-07 |
|
ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA); Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). GABA is the major inhibitory neurotransmitter in the mammalian CNS and, like glutamate and other transmitters, acts via both ligand gated ion channels (GABAa receptors) and G-protein coupled receptors (GABAb receptor or GABAbR). GABAa receptors are members of the ionotropic receptor superfamily which includes alpha-adrenergic and glycine receptors. The GABAb receptor is a member of a receptor superfamily which includes the mGlu receptors. The GABAb receptor is coupled to G alpha-i proteins, and activation causes a decrease in calcium, an increase in potassium membrane conductance, and inhibition of cAMP formation. The response is thus inhibitory and leads to hyperpolarization and decreased neurotransmitter release, for example.
Pssm-ID: 380589 [Multi-domain] Cd Length: 404 Bit Score: 51.86 E-value: 2.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 33 PLTGPQAV-SGKDDENGLRLAVETLNRTPITVdgQPVRFRIVAEDDQADPRTGVQVAQRLLDRQPA--AFFGPENSGVAI 109
Cdd:cd06366 7 PLSGSKGWwGGAGILPAAEMALEHINNRSDIL--PGYNLELIWNDTQCDPGLGLKALYDLLYTPPPkvMLLGPGCSSVTE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 110 PVARLTN---------AARVPMLtvaSNPQLtalgYDNVFRTGASDSVLGASMAAFAAgKLGAKTAAVIDDRTAYGQGLA 180
Cdd:cd06366 85 PVAEASKywnlvqlsyAATSPAL---SDRKR----YPYFFRTVPSDTAFNPARIALLK-HFGWKRVATIYQNDEVFSSTA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 181 EQFIAKAKSLGLQVVARE-FTHSQATDFLAILatikgKNPDV-IFFGGYTAQAAPMAkqmvqrgvrarllggdgICSA-- 256
Cdd:cd06366 157 EDLEELLEEANITIVATEsFSSEDPTDQLENL-----KEKDArIIIGLFYEDAARKV-----------------FCEAyk 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 257 -NM----------GTVAQ----TASRNVYC-----------------AMSGSGLDRTEAGR---DYVARYRARFkSEPQT 301
Cdd:cd06366 215 lGMygpkyvwilpGWYDDnwwdVPDNDVNCtpeqmlealeghfstelLPLNPDNTKTISGLtaqEFLKEYLERL-SNSNY 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 302 YGITY----YDGMLLLAKTMAAAQTTDPAK-----------------LIQALRSASHEGVAGTYAFTVRGELMnAPTTVF 360
Cdd:cd06366 294 TGSPYapfaYDAVWAIALALNKTIEKLAEYnktledftyndkemadlFLEAMNSTSFEGVSGPVSFDSKGDRL-GTVDIE 372
|
410
....*....|
gi 737992313 361 TFEDGQMVPV 370
Cdd:cd06366 373 QLQGGSYVKV 382
|
|
| PBP1_NPR-like |
cd06373 |
Ligand binding domain of natriuretic peptide receptor (NPR) family; Ligand binding domain of ... |
49-169 |
2.45e-06 |
|
Ligand binding domain of natriuretic peptide receptor (NPR) family; Ligand binding domain of natriuretic peptide receptor (NPR) family which consists of three different subtypes: type A natriuretic peptide receptor (NPR-A, or GC-A), type B natriuretic peptide receptors (NPR-B, or GC-B), and type C natriuretic peptide receptor (NPR-C). There are three types of natriuretic peptide (NP) ligands specific to the receptors: atrial NP (ANP), brain or B-type NP (BNP), and C-type NP (CNP). The NP family is thought to have arisen through gene duplication during evolution and plays an essential role in cardiovascular and body fluid homeostasis. ANP and BNP bind mainly to NPR-A, while CNP binds specifically to NPR-B. Both NPR-A and NPR-B have guanylyl cyclase catalytic activity and produces intracellular secondary messenger cGMP in response to peptide-ligand binding. Consequently, the NPR-A activation results in vasodilation and inhibition of vascular smooth muscle cell proliferation. NPR-C acts as the receptor for all the three members of NP family, and functions as a clearance receptor. Unlike NPR-A and -B, NPR-C lacks an intracellular guanylyl cyclase domain and is thought to exert biological actions by sequestration of released natriuretic peptides and/or inhibition of adenylyl cyclase.
Pssm-ID: 380596 [Multi-domain] Cd Length: 394 Bit Score: 49.19 E-value: 2.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 49 LRLAVETLNRTPITVDgqpVRFRIVAEDDQADPRTGVQVAQ-RLLDRQPAAFFGPENSGVAIPVARLTNAARVPMLTVAS 127
Cdd:cd06373 23 IELALRRVERRGFLPG---WRFQVHYRDTKCSDTLAPLAAVdLYCAKKVDVFLGPVCEYALAPVARYAGHWNVPVLTAGG 99
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 737992313 128 N----------PQLTalgydnvfRTGASDSVLGASMAAFAAgKLGAKTAAVI 169
Cdd:cd06373 100 LaagfddkteyPLLT--------RMGGSYVKLGEFVLTLLR-HFGWRRVALL 142
|
|
| PBP1_NPR_A |
cd06385 |
Ligand-binding domain of type A natriuretic peptide receptor; Ligand-binding domain of type A ... |
49-251 |
1.72e-05 |
|
Ligand-binding domain of type A natriuretic peptide receptor; Ligand-binding domain of type A natriuretic peptide receptor (NPR-A). NPR-A is one of three known single membrane-spanning natriuretic peptide receptors that regulate blood volume, blood pressure, ventricular hypertrophy, pulmonary hypertension, fat metabolism, and long bone growth. In mammals there are three natriuretic peptides: ANP, BNP, and CNP. NPR-A is highly expressed in kidney, adrenal, terminal ileum, adipose, aortic, and lung tissues. The rank order of NPR-A activation by natriuretic peptides is ANP>BNP>>CNP. Single allele-inactivating mutations in the promoter of human NPR-A are associated with hypertension and heart failure.
Pssm-ID: 380608 [Multi-domain] Cd Length: 408 Bit Score: 46.35 E-value: 1.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 49 LRLAVETLNRTPITVDGQPVRFRI-VAED------DQADPRTGVQVAqrlLDRQPAAFFGPENSGVAIPVARLTNAARVP 121
Cdd:cd06385 24 VELALERVNARPDLLPGWHVRTVLgSSENkegvcsDSTAPLVAVDLK---FEHHPAVFLGPGCVYTAAPVARFTAHWRVP 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 122 MLTVASNPQ--LTALGYDNVFRTGASDSVLGASMAAFAAgKLGAKTAAVI-------DDRTAY--GQGLAEQFIAKaksL 190
Cdd:cd06385 101 LLTAGAPALgfGVKDEYALTTRTGPSHKKLGEFVARLHR-RYGWERRALLvyadrkgDDRPCFfaVEGLYMQLRRR---L 176
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 737992313 191 GLQVVAREFTHSQATDFLAILATIKGKNPDViffggYTAQAAPMAKQMVQRGVRARLLGGD 251
Cdd:cd06385 177 NITVDDLVFNEDEPLNYTELLRDIRQKGRVI-----YVCCSPDTFRKLMLQAWREGLCGED 232
|
|
| PBP1_NPR_GC-like |
cd06352 |
ligand-binding domain of membrane guanylyl-cyclase receptors; Ligand-binding domain of ... |
16-215 |
5.75e-05 |
|
ligand-binding domain of membrane guanylyl-cyclase receptors; Ligand-binding domain of membrane guanylyl-cyclase receptors. Membrane guanylyl cyclases (GC) have a single membrane-spanning region and are activated by endogenous and exogenous peptides. This family can be divided into three major subfamilies: the natriuretic peptide receptors (NPRs), sensory organ-specific membrane GCs, and the enterotoxin/guanylin receptors. The binding of peptide ligands to the receptor results in the activation of the cytosolic catalytic domain. Three types of NPRs have been cloned from mammalian tissues: NPR-A/GC-A, NPR-B/ GC-B, and NPR-C. In addition, two of the GCs, GC-D and GC-G, appear to be pseudogenes in humans. Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are produced in the heart, and both bind to the NPR-A. NPR-C, also termed the clearance receptor, binds each of the natriuretic peptides and can alter circulating levels of these peptides. The ligand binding domain of the NPRs exhibits strong structural similarity to the type 1 periplasmic binding fold protein family.
Pssm-ID: 380575 [Multi-domain] Cd Length: 391 Bit Score: 44.65 E-value: 5.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 16 TIGAAHAERVVTIAFSGPLTGPqavsgkddenGLRLAVETLNRTPITVDGQPVRFRIVAEDDQADpRTGVQVAQRLLDRQ 95
Cdd:cd06352 1 KVGVLAPSNSQSLPVGYARSAP----------AIDIAIERINSEGLLLPGFNFEFTYRDSCCDES-EAVGAAADLIYKRN 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 96 PAAFFGPENSGVAIPVARLTNAARVPMLTV--ASNPQLTALGYDNVFRTGASDSVLGASMAAFaAGKLGAKTAAVI-DDR 172
Cdd:cd06352 70 VDVFIGPACSAAADAVGRLATYWNIPIITWgaVSASFLDKSRYPTLTRTSPNSLSLAEALLAL-LKQFNWKRAAIIySDD 148
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 737992313 173 TAYGQGLAEQFI-AKAKSLGLQVVAREFTH-SQATDFLAILATIK 215
Cdd:cd06352 149 DSKCFSIANDLEdALNQEDNLTISYYEFVEvNSDSDYSSILQEAK 193
|
|
| PBP1_NPR_B |
cd06384 |
ligand-binding domain of type B natriuretic peptide receptor; Ligand-binding domain of type B ... |
23-151 |
8.36e-04 |
|
ligand-binding domain of type B natriuretic peptide receptor; Ligand-binding domain of type B natriuretic peptide receptor (NPR-B). NPR-B is one of three known single membrane-spanning natriuretic peptide receptors that have been identified. Natriuretic peptides are family of structurally related but genetically distinct hormones/paracrine factors that regulate blood volume, blood pressure, ventricular hypertrophy, pulmonary hypertension, fat metabolism, and long bone growth. In mammals there are three natriuretic peptides: ANP, BNP, and CNP. Like NPR-A (or GC-A), NPR-B (or GC-B) is a transmembrane guanylyl cyclase, an enzyme that catalyzes the synthesis of cGMP. NPR-B is the predominant natriuretic peptide receptor in the brain. The rank of order activation of NPR-B by natriuretic peptides is CNP>>ANP>BNP. Homozygous inactivating mutations in human NPR-B cause a form of short-limbed dwarfism known as acromesomelic dysplasia type Maroteaux.
Pssm-ID: 380607 [Multi-domain] Cd Length: 399 Bit Score: 40.99 E-value: 8.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 23 ERVVTIAFSGPLTGPqavsgkddenGLRLAVETLNRTPITVDGQPVRFRIVAEDDQAD------PRTGVQVAqrlLDRQP 96
Cdd:cd06384 8 ENNLSYAWAWPRVFP----------ALRMAVDALQRKGKLLRGYTVNLLFHSSELQGAcseyvaPLMAVDLK---LYHDP 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 737992313 97 AAFFGPENSGVAIPVARLTNAARVPMLT---VASNPQLTALGYDNVFRTGASDSVLGA 151
Cdd:cd06384 75 DVLFGPGCVYPAASVGRFASHWRLPLITagaVAFGFSSKDEHYRTTVRTGPSAPKLGE 132
|
|
| PBP1_ABC_sugar_binding-like |
cd19972 |
monosaccharide ABC transporter substrate-binding protein; Periplasmic sugar-binding domain of ... |
70-236 |
9.45e-03 |
|
monosaccharide ABC transporter substrate-binding protein; Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consists of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.
Pssm-ID: 380627 [Multi-domain] Cd Length: 269 Bit Score: 37.42 E-value: 9.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 70 FRIVAEDDQADPRTGVQVAQRLLDRQPAAF-FGPENSGVAIPVARLTNAARVPMLTVASNPQ----LTALGYDNVFRTGA 144
Cdd:cd19972 30 YKVITVDAKGDSATQVNQIQDLITQNIDALiYIPAGATAAAVPVKAARAAGIPVIAVDRNPEdapgDTFIATDSVAAAKE 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 737992313 145 -----SDSVLGASMAAFAAGKLGakTAAVIDDRTAYGQGLAEqfiakakSLGLQVVAREFTHSQATDFLAILATIKGKNP 219
Cdd:cd19972 110 lgewvIKQTGGKGEIAILHGQLG--TTPEVDRTKGFQEALAE-------APGIKVVAEQTADWDQDEGFKVAQDMLQANP 180
|
170
....*....|....*...
gi 737992313 220 DV-IFFGGYTAQAAPMAK 236
Cdd:cd19972 181 NItVFFGQSDAMALGAAQ 198
|
|
| |
