|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07314 |
PRK07314 |
beta-ketoacyl-ACP synthase II; |
3-411 |
0e+00 |
|
beta-ketoacyl-ACP synthase II;
Pssm-ID: 235987 [Multi-domain] Cd Length: 411 Bit Score: 738.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 3 RRRVVVTGLGLISPVGNNVADGWANLVAGRSGIANITKFDATNYSTRFAGEVKGFNVEEYLPAKEARHMDTFIHYGIAAG 82
Cdd:PRK07314 1 KRRVVVTGLGAVSPLGNDVESTWKNLLAGKSGIGPITHFDTSDLAVKIAGEVKDFNPDDYMSRKEARRMDRFIQYGIAAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 83 MQAMKDSGIEVTEENAERFGVVVGSGIGGLPMIEVTQTELLNRGPRRISPFFVPASIINMISGHLSIKFGLKGPNLAIVT 162
Cdd:PRK07314 81 KQAVEDAGLEITEENADRIGVIIGSGIGGLETIEEQHITLLEKGPRRVSPFFVPMAIINMAAGHVSIRYGAKGPNHSIVT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 163 ACTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARALSQRNDDPATASRPWDKDRDGFVLGEGAGVMVLE 242
Cdd:PRK07314 161 ACATGAHAIGDAARLIAYGDADVMVAGGAEAAITPLGIAGFAAARALSTRNDDPERASRPFDKDRDGFVMGEGAGILVLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 243 EYEHAKARGAKIYAEVSGYGMSADAYHMTAPVEDGDGARRCMLAALRNAGVNPDEVNYLNAHGTSTQLGDLAETIGIKRA 322
Cdd:PRK07314 241 ELEHAKARGAKIYAEVVGYGMTGDAYHMTAPAPDGEGAARAMKLALKDAGINPEDIDYINAHGTSTPAGDKAETQAIKRV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 323 FGDRAKQMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPECDLDYCANEARDMKIDVALKNSFGFGG 402
Cdd:PRK07314 321 FGEHAYKVAVSSTKSMTGHLLGAAGAVEAIFSVLAIRDQVIPPTINLDNPDEECDLDYVPNEARERKIDYALSNSFGFGG 400
|
....*....
gi 738072904 403 TNGTLVFKR 411
Cdd:PRK07314 401 TNASLVFKR 409
|
|
| fabF |
TIGR03150 |
beta-ketoacyl-acyl-carrier-protein synthase II; 3-oxoacyl-[acyl-carrier-protein] synthase 2 ... |
4-410 |
0e+00 |
|
beta-ketoacyl-acyl-carrier-protein synthase II; 3-oxoacyl-[acyl-carrier-protein] synthase 2 (KAS-II, FabF) is involved in the condensation step of fatty acid biosynthesis in which the malonyl donor group is decarboxylated and the resulting carbanion used to attack and extend the acyl group attached to the acyl carrier protein. Most genomes encoding fatty acid biosynthesis contain a number of condensing enzymes, often of all three types: 1, 2 and 3. Synthase 2 is mechanistically related to synthase 1 (KAS-I, FabB) containing a number of absolutely conserved catalytic residues in common. This model is based primarily on genes which are found in apparent operons with other essential genes of fatty acid biosynthesis (GenProp0681). The large gap between the trusted cutoff and the noise cutoff contains many genes which are not found adjacent to genes of the fatty acid pathway in genomes that often also contain a better hit to this model. These genes may be involved in other processes such as polyketide biosyntheses. Some genomes contain more than one above-trusted hit to this model which may result from recent paralogous expansions. Second hits to this model which are not next to other fatty acid biosynthesis genes may be involved in other processes. FabB sequences should fall well below the noise cutoff of this model. [Fatty acid and phospholipid metabolism, Biosynthesis]
Pssm-ID: 274452 [Multi-domain] Cd Length: 407 Bit Score: 713.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 4 RRVVVTGLGLISPVGNNVADGWANLVAGRSGIANITKFDATNYSTRFAGEVKGFNVEEYLPAKEARHMDTFIHYGIAAGM 83
Cdd:TIGR03150 1 RRVVVTGLGAVTPLGNGVEEFWENLLAGKSGIGPITRFDASDLPVKIAGEVKDFDPEDYIDKKEARRMDRFIQYALAAAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 84 QAMKDSGIEVTEENAERFGVVVGSGIGGLPMIEVTQTELLNRGPRRISPFFVPASIINMISGHLSIKFGLKGPNLAIVTA 163
Cdd:TIGR03150 81 EAVEDSGLDIEEEDAERVGVIIGSGIGGLETIEEQHIVLLEKGPRRVSPFFIPMSIINMAAGQISIRYGAKGPNHAVVTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 164 CTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARALSQRNDDPATASRPWDKDRDGFVLGEGAGVMVLEE 243
Cdd:TIGR03150 161 CATGTHAIGDAFRLIQRGDADVMIAGGAEAAITPLGIAGFAAMKALSTRNDDPEKASRPFDKDRDGFVMGEGAGVLVLEE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 244 YEHAKARGAKIYAEVSGYGMSADAYHMTAPVEDGDGARRCMLAALRNAGVNPDEVNYLNAHGTSTQLGDLAETIGIKRAF 323
Cdd:TIGR03150 241 LEHAKARGAKIYAEIVGYGMSGDAYHITAPAPEGEGAARAMRAALKDAGINPEDVDYINAHGTSTPLGDKAETKAIKKVF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 324 GDRAKQMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPECDLDYCANEARDMKIDVALKNSFGFGGT 403
Cdd:TIGR03150 321 GDHAYKLAVSSTKSMTGHLLGAAGAIEAIFTVLAIRDGIVPPTINLDNPDPECDLDYVPNEAREAKIDYALSNSFGFGGT 400
|
....*..
gi 738072904 404 NGTLVFK 410
Cdd:TIGR03150 401 NASLVFK 407
|
|
| FabB |
COG0304 |
3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary ... |
4-412 |
0e+00 |
|
3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; 3-oxoacyl-(acyl-carrier-protein) synthase is part of the Pathway/BioSystem: Fatty acid biosynthesis
Pssm-ID: 440073 [Multi-domain] Cd Length: 409 Bit Score: 649.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 4 RRVVVTGLGLISPVGNNVADGWANLVAGRSGIANITKFDATNYSTRFAGEVKGFNVEEYLPAKEARHMDTFIHYGIAAGM 83
Cdd:COG0304 1 RRVVITGLGAVSPLGNGVEEFWEALLAGRSGIRPITRFDASGLPVRIAGEVKDFDPEEYLDRKELRRMDRFTQYALAAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 84 QAMKDSGIEVTEENAERFGVVVGSGIGGLPMIEVTQTELLNRGPRRISPFFVPASIINMISGHLSIKFGLKGPNLAIVTA 163
Cdd:COG0304 81 EALADAGLDLDEVDPDRTGVIIGSGIGGLDTLEEAYRALLEKGPRRVSPFFVPMMMPNMAAGHVSIRFGLKGPNYTVSTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 164 CTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARALSQRNDDPATASRPWDKDRDGFVLGEGAGVMVLEE 243
Cdd:COG0304 161 CASGAHAIGEAYRLIRRGRADVMIAGGAEAAITPLGLAGFDALGALSTRNDDPEKASRPFDKDRDGFVLGEGAGVLVLEE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 244 YEHAKARGAKIYAEVSGYGMSADAYHMTAPVEDGDGARRCMLAALRNAGVNPDEVNYLNAHGTSTQLGDLAETIGIKRAF 323
Cdd:COG0304 241 LEHAKARGAKIYAEVVGYGASSDAYHITAPAPDGEGAARAMRAALKDAGLSPEDIDYINAHGTSTPLGDAAETKAIKRVF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 324 GDRAKQMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPECDLDYCANEARDMKIDVALKNSFGFGGT 403
Cdd:COG0304 321 GDHAYKVPVSSTKSMTGHLLGAAGAIEAIASVLALRDGVIPPTINLENPDPECDLDYVPNEAREAKIDYALSNSFGFGGH 400
|
....*....
gi 738072904 404 NGTLVFKRA 412
Cdd:COG0304 401 NASLVFKRY 409
|
|
| KAS_I_II |
cd00834 |
Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible ... |
4-409 |
0e+00 |
|
Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.
Pssm-ID: 238430 [Multi-domain] Cd Length: 406 Bit Score: 587.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 4 RRVVVTGLGLISPVGNNVADGWANLVAGRSGIANITKFDATNYSTRFAGEVKGFNVEEYLPAKEARHMDTFIHYGIAAGM 83
Cdd:cd00834 1 RRVVITGLGAVTPLGNGVEEFWEALLAGRSGIRPITRFDASGFPSRIAGEVPDFDPEDYLDRKELRRMDRFAQFALAAAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 84 QAMKDSGIEVTEENAERFGVVVGSGIGGLPMIEVTQTELLNRGPRRISPFFVPASIINMISGHLSIKFGLKGPNLAIVTA 163
Cdd:cd00834 81 EALADAGLDPEELDPERIGVVIGSGIGGLATIEEAYRALLEKGPRRVSPFFVPMALPNMAAGQVAIRLGLRGPNYTVSTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 164 CTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARALSQRNDDPATASRPWDKDRDGFVLGEGAGVMVLEE 243
Cdd:cd00834 161 CASGAHAIGDAARLIRLGRADVVIAGGAEALITPLTLAGFAALRALSTRNDDPEKASRPFDKDRDGFVLGEGAGVLVLES 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 244 YEHAKARGAKIYAEVSGYGMSADAYHMTAPVEDGDGARRCMLAALRNAGVNPDEVNYLNAHGTSTQLGDLAETIGIKRAF 323
Cdd:cd00834 241 LEHAKARGAKIYAEILGYGASSDAYHITAPDPDGEGAARAMRAALADAGLSPEDIDYINAHGTSTPLNDAAESKAIKRVF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 324 GDRAKQMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPECDLDYCANEARDMKIDVALKNSFGFGGT 403
Cdd:cd00834 321 GEHAKKVPVSSTKSMTGHLLGAAGAVEAIATLLALRDGVLPPTINLEEPDPECDLDYVPNEAREAPIRYALSNSFGFGGH 400
|
....*.
gi 738072904 404 NGTLVF 409
Cdd:cd00834 401 NASLVF 406
|
|
| PRK08722 |
PRK08722 |
beta-ketoacyl-ACP synthase II; |
1-411 |
0e+00 |
|
beta-ketoacyl-ACP synthase II;
Pssm-ID: 181539 [Multi-domain] Cd Length: 414 Bit Score: 544.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 1 MSRRRVVVTGLGLISPVGNNVADGWANLVAGRSGIANITKFDATNYSTRFAGEVKGFNVEEYLPAKEARHMDTFIHYGIA 80
Cdd:PRK08722 1 MSKRRVVVTGMGMLSPVGNTVESSWKALLAGQSGIVNIEHFDTTNFSTRFAGLVKDFNCEEYMSKKDARKMDLFIQYGIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 81 AGMQAMKDSGIEVTEENAERFGVVVGSGIGGLPMIEVTQTELLNRGPRRISPFFVPASIINMISGHLSIKFGLKGPNLAI 160
Cdd:PRK08722 81 AGIQALDDSGLEVTEENAHRIGVAIGSGIGGLGLIEAGHQALVEKGPRKVSPFFVPSTIVNMIAGNLSIMRGLRGPNIAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 161 VTACTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARALSQRNDDPATASRPWDKDRDGFVLGEGAGVMV 240
Cdd:PRK08722 161 STACTTGLHNIGHAARMIAYGDADAMVAGGAEKASTPLGMAGFGAAKALSTRNDEPQKASRPWDKDRDGFVLGDGAGMMV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 241 LEEYEHAKARGAKIYAEVSGYGMSADAYHMTAPVEDGDGARRCMLAALRNAGVNPDEVNYLNAHGTSTQLGDLAETIGIK 320
Cdd:PRK08722 241 LEEYEHAKARGAKIYAELVGFGMSGDAYHMTSPSEDGSGGALAMEAAMRDAGVTGEQIGYVNAHGTSTPAGDVAEIKGIK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 321 RAFGDR-AKQMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPECDLDYCANEARDMK-IDVALKNSF 398
Cdd:PRK08722 321 RALGEAgSKQVLVSSTKSMTGHLLGAAGSVEAIITVMSLVDQIVPPTINLDDPEEGLDIDLVPHTARKVEsMEYAICNSF 400
|
410
....*....|...
gi 738072904 399 GFGGTNGTLVFKR 411
Cdd:PRK08722 401 GFGGTNGSLIFKK 413
|
|
| PRK06333 |
PRK06333 |
beta-ketoacyl-ACP synthase; |
1-411 |
0e+00 |
|
beta-ketoacyl-ACP synthase;
Pssm-ID: 235781 [Multi-domain] Cd Length: 424 Bit Score: 534.96 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 1 MSRRRVVVTGLGLISPVGNNVADGWANLVAGRSGIANITKFDATNYSTRFAGEVK--------GFNVEEYLPAKEARHMD 72
Cdd:PRK06333 1 MNKKRIVVTGMGAVSPLGCGVETFWQRLLAGQSGIRTLTDFPVGDLATKIGGQVPdlaedaeaGFDPDRYLDPKDQRKMD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 73 TFIHYGIAAGMQAMKDSGI-EVTEENAERFGVVVGSGIGGLPMIEVTQTELLNRGPRRISPFFVPASIINMISGHLSIKF 151
Cdd:PRK06333 81 RFILFAMAAAKEALAQAGWdPDTLEDRERTATIIGSGVGGFPAIAEAVRTLDSRGPRRLSPFTIPSFLTNMAAGHVSIRY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 152 GLKGPNLAIVTACTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARALSQR-NDDPATASRPWDKDRDGF 230
Cdd:PRK06333 161 GFKGPLGAPVTACAAGVQAIGDAARLIRSGEADVAVCGGTEAAIDRVSLAGFAAARALSTRfNDAPEQASRPFDRDRDGF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 231 VLGEGAGVMVLEEYEHAKARGAKIYAEVSGYGMSADAYHMTAPVEDGDGARRCMLAALRNAGVNPDEVNYLNAHGTSTQL 310
Cdd:PRK06333 241 VMGEGAGILVIETLEHALARGAPPLAELVGYGTSADAYHMTAGPEDGEGARRAMLIALRQAGIPPEEVQHLNAHATSTPV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 311 GDLAETIGIKRAFGdRAKQMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPECD-LDYCANEARDMK 389
Cdd:PRK06333 321 GDLGEVAAIKKVFG-HVSGLAVSSTKSATGHLLGAAGGVEAIFTILALRDQIAPPTLNLENPDPAAEgLDVVANKARPMD 399
|
410 420
....*....|....*....|..
gi 738072904 390 IDVALKNSFGFGGTNGTLVFKR 411
Cdd:PRK06333 400 MDYALSNGFGFGGVNASILFRR 421
|
|
| PRK08439 |
PRK08439 |
3-oxoacyl-(acyl carrier protein) synthase II; Reviewed |
4-411 |
8.39e-175 |
|
3-oxoacyl-(acyl carrier protein) synthase II; Reviewed
Pssm-ID: 236265 [Multi-domain] Cd Length: 406 Bit Score: 493.87 E-value: 8.39e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 4 RRVVVTGLGLISPVGNNVADGWANLVAGRSGIANITKFDATNYSTRFAGEVKGFNVEEYLPAKEARHMDTFIHYGIAAGM 83
Cdd:PRK08439 2 KRVVVTGIGMINSLGLNKESSFKAICNGECGIKKITLFDASDFPVQIAGEITDFDPTEVMDPKEVKKADRFIQLGLKAAR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 84 QAMKDSGIEVTEENAERFGVVVGSGIGGLPMIEVTQTELLNRGPRRISPFFVPASIINMISGHLSIKFGLKGPNLAIVTA 163
Cdd:PRK08439 82 EAMKDAGFLPEELDAERFGVSSASGIGGLPNIEKNSIICFEKGPRKISPFFIPSALVNMLGGFISIEHGLKGPNLSSVTA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 164 CTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARALSQRNDDPATASRPWDKDRDGFVLGEGAGVMVLEE 243
Cdd:PRK08439 162 CAAGTHAIIEAVKTIMLGGADKMLVVGAESAICPVGIGGFAAMKALSTRNDDPKKASRPFDKDRDGFVMGEGAGALVLEE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 244 YEHAKARGAKIYAEVSGYGMSADAYHMTAPVEdgDGARRCMLAALRNAGvNPdEVNYLNAHGTSTQLGDLAETIGIKRAF 323
Cdd:PRK08439 242 YESAKKRGAKIYAEIIGFGESGDANHITSPAP--EGPLRAMKAALEMAG-NP-KIDYINAHGTSTPYNDKNETAALKELF 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 324 GDRAKQMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPECDLDYCANEARDMKIDVALKNSFGFGGT 403
Cdd:PRK08439 318 GSKEKVPPVSSTKGQIGHCLGAAGAIEAVISIMAMRDGILPPTINQETPDPECDLDYIPNVARKAELNVVMSNSFGFGGT 397
|
....*...
gi 738072904 404 NGTLVFKR 411
Cdd:PRK08439 398 NGVVIFKK 405
|
|
| PTZ00050 |
PTZ00050 |
3-oxoacyl-acyl carrier protein synthase; Provisional |
13-411 |
1.79e-150 |
|
3-oxoacyl-acyl carrier protein synthase; Provisional
Pssm-ID: 240245 [Multi-domain] Cd Length: 421 Bit Score: 432.58 E-value: 1.79e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 13 LISPVGNNVADGWANLVAGRSGIANITKFDA----------------TNYSTRFAGEVKG--FNVEEYLPAKearHMDTF 74
Cdd:PTZ00050 1 VVTPLGVGAESTWEALIAGKSGIRKLTEFPKflpdcipeqkalenlvAAMPCQIAAEVDQseFDPSDFAPTK---RESRA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 75 IHYGIAAGMQAMKDSGIEVTEE-NAERFGVVVGSGIGGLPMIEVTQTELLNRGPRRISPFFVPASIINMISGHLSIKFGL 153
Cdd:PTZ00050 78 THFAMAAAREALADAKLDILSEkDQERIGVNIGSGIGSLADLTDEMKTLYEKGHSRVSPYFIPKILGNMAAGLVAIKHKL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 154 KGPNLAIVTACTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARALSQR-NDDPATASRPWDKDRDGFVL 232
Cdd:PTZ00050 158 KGPSGSAVTACATGAHCIGEAFRWIKYGEADIMICGGTEASITPVSFAGFSRMRALCTKyNDDPQRASRPFDKDRAGFVM 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 233 GEGAGVMVLEEYEHAKARGAKIYAEVSGYGMSADAYHMTAPVEDGDGARRCMLAALRNAG-VNPDEVNYLNAHGTSTQLG 311
Cdd:PTZ00050 238 GEGAGILVLEELEHALRRGAKIYAEIRGYGSSSDAHHITAPHPDGRGARRCMENALKDGAnININDVDYVNAHATSTPIG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 312 DLAETIGIKRAFGDR-AKQMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPECDLDYCANE-ARDMK 389
Cdd:PTZ00050 318 DKIELKAIKKVFGDSgAPKLYVSSTKGGLGHLLGAAGAVESIVTILSLYEQIIPPTINLENPDAECDLNLVQGKtAHPLQ 397
|
410 420
....*....|....*....|...
gi 738072904 390 -IDVALKNSFGFGGTNGTLVFKR 411
Cdd:PTZ00050 398 sIDAVLSTSFGFGGVNTALLFTK 420
|
|
| PLN02836 |
PLN02836 |
3-oxoacyl-[acyl-carrier-protein] synthase |
4-409 |
3.70e-137 |
|
3-oxoacyl-[acyl-carrier-protein] synthase
Pssm-ID: 215449 [Multi-domain] Cd Length: 437 Bit Score: 399.55 E-value: 3.70e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 4 RRVVVTGLGLISPVGNNVADGWANLVAGRSGIANITKFDA--------------TNYSTRFAGEV-KGFNVEEYLPAK-- 66
Cdd:PLN02836 6 RRVVVTGLGLVTPLGCGVETTWRRLIAGECGVRALTQDDLkmksedeetqlytlDQLPSRVAALVpRGTGPGDFDEELwl 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 67 EARHMDTFIHYGIAAGMQAMKDSGIEVTE-ENAERFGVVVGSGIGGLPMI-EVTQTELLNRGpRRISPFFVPASIINMIS 144
Cdd:PLN02836 86 NSRSSSRFIGYALCAADEALSDARWLPSEdEAKERTGVSIGGGIGSITDIlEAAQLICEKRL-RRLSPFFVPRILINMAA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 145 GHLSIKFGLKGPNLAIVTACTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARALSQR-NDDPATASRPW 223
Cdd:PLN02836 165 GHVSIRYGFQGPNHAAVTACATGAHSIGDAFRMIQFGDADVMVAGGTESSIDALSIAGFSRSRALSTKfNSCPTEASRPF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 224 DKDRDGFVLGEGAGVMVLEEYEHAKARGAKIYAEVSGYGMSADAYHMTAPVEDGDGARRCMLAALRNAGVNPDEVNYLNA 303
Cdd:PLN02836 245 DCDRDGFVIGEGAGVLVLEELEHAKRRGAKIYAEVRGYGMSGDAHHITQPHEDGRGAVLAMTRALQQSGLHPNQVDYVNA 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 304 HGTSTQLGDLAETIGIKRAFGDRAKQ--MVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPECDLDYC 381
Cdd:PLN02836 325 HATSTPLGDAVEARAIKTVFSEHATSggLAFSSTKGATGHLLGAAGAVEAIFSVLAIHHGIAPPTLNLERPDPIFDDGFV 404
|
410 420
....*....|....*....|....*....
gi 738072904 382 A-NEARDMKIDVALKNSFGFGGTNGTLVF 409
Cdd:PLN02836 405 PlTASKAMLIRAALSNSFGFGGTNASLLF 433
|
|
| PLN02787 |
PLN02787 |
3-oxoacyl-[acyl-carrier-protein] synthase II |
1-409 |
4.12e-125 |
|
3-oxoacyl-[acyl-carrier-protein] synthase II
Pssm-ID: 215421 [Multi-domain] Cd Length: 540 Bit Score: 372.39 E-value: 4.12e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 1 MSRRRVVVTGLGLISPVGNNVADGWANLVAGRSGIANITKFDATNYSTRFAGEVKGFNVEEYLPAKEARHMDTFIHYGIA 80
Cdd:PLN02787 126 TKQRRVVVTGMGVVSPLGHDPDVFYNNLLEGVSGISEIERFDCSQFPTRIAGEIKSFSTDGWVAPKLSKRMDKFMLYLLT 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 81 AGMQAMKDSGIevTEENAERFGVVVGSGIGGLPM--IEV--TQTELLNRGPRRISPFFVPASIINMISGHLSIKFGLKGP 156
Cdd:PLN02787 206 AGKKALADGGI--TEDVMKELDKTKCGVLIGSAMggMKVfnDAIEALRISYRKMNPFCVPFATTNMGSAMLAMDLGWMGP 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 157 NLAIVTACTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARALSQRNDDPATASRPWDKDRDGFVLGEGA 236
Cdd:PLN02787 284 NYSISTACATSNFCILNAANHIIRGEADVMLCGGSDAAIIPIGLGGFVACRALSQRNDDPTKASRPWDMNRDGFVMGEGA 363
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 237 GVMVLEEYEHAKARGAKIYAEVSGYGMSADAYHMTAPVEDGDGARRCMLAALRNAGVNPDEVNYLNAHGTSTQLGDLAET 316
Cdd:PLN02787 364 GVLLLEELEHAKKRGANIYAEFLGGSFTCDAYHMTEPHPEGAGVILCIEKALAQSGVSKEDVNYINAHATSTKAGDLKEY 443
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 317 IGIKRAFGdRAKQMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPECDLD-YCANEARDMKIDVALK 395
Cdd:PLN02787 444 QALMRCFG-QNPELRVNSTKSMIGHLLGAAGAVEAIATVQAIRTGWVHPNINLENPESGVDTKvLVGPKKERLDIKVALS 522
|
410
....*....|....
gi 738072904 396 NSFGFGGTNGTLVF 409
Cdd:PLN02787 523 NSFGFGGHNSSILF 536
|
|
| PRK07967 |
PRK07967 |
beta-ketoacyl-ACP synthase I; |
4-411 |
8.17e-106 |
|
beta-ketoacyl-ACP synthase I;
Pssm-ID: 181184 [Multi-domain] Cd Length: 406 Bit Score: 318.54 E-value: 8.17e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 4 RRVVVTGLGLISPVGNNVADGWANLVAGRSGIANITKFDATNYSTRFAGEVKgFNVEEYLPAKEARHMDTFIHYGIAAGM 83
Cdd:PRK07967 2 RRVVITGLGIVSSIGNNQQEVLASLREGRSGITFSPEFAEMGMRSQVWGNVK-LDPTGLIDRKVMRFMGDASAYAYLAME 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 84 QAMKDSGIEVTEENAERFG-VVVGSGIGGLPMIEVTQTELLNRGPRRISPFFVPASIINMISGHLSIKFGLKGPNLAIVT 162
Cdd:PRK07967 81 QAIADAGLSEEQVSNPRTGlIAGSGGGSTRNQVEAADAMRGPRGPKRVGPYAVTKAMASTVSACLATPFKIKGVNYSISS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 163 ACTTGLHCIGEAARLIEYGDADLMIAGGAEA---TVSPLgiggFAAARALS-QRNDDPATASRPWDKDRDGFVLGEGAGV 238
Cdd:PRK07967 161 ACATSAHCIGNAVEQIQLGKQDIVFAGGGEEldwEMSCL----FDAMGALStKYNDTPEKASRAYDANRDGFVIAGGGGV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 239 MVLEEYEHAKARGAKIYAEVSGYGMSADAYHMTAPveDGDGARRCMLAALrnAGVNPDeVNYLNAHGTSTQLGDLAETIG 318
Cdd:PRK07967 237 VVVEELEHALARGAKIYAEIVGYGATSDGYDMVAP--SGEGAVRCMQMAL--ATVDTP-IDYINTHGTSTPVGDVKELGA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 319 IKRAFGDRAKQmvVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPE-CDLDYCANEARDMKIDVALKNS 397
Cdd:PRK07967 312 IREVFGDKSPA--ISATKSLTGHSLGAAGVQEAIYSLLMMEHGFIAPSANIEELDPQaAGMPIVTETTDNAELTTVMSNS 389
|
410
....*....|....
gi 738072904 398 FGFGGTNGTLVFKR 411
Cdd:PRK07967 390 FGFGGTNATLVFRR 403
|
|
| PRK14691 |
PRK14691 |
3-oxoacyl-(acyl carrier protein) synthase II; Provisional |
124-411 |
1.84e-98 |
|
3-oxoacyl-(acyl carrier protein) synthase II; Provisional
Pssm-ID: 173154 [Multi-domain] Cd Length: 342 Bit Score: 297.41 E-value: 1.84e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 124 NRGPRRISPFFVPASIINMISGHLSIKFGLKGPNLAIVTACTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGF 203
Cdd:PRK14691 51 SRGPKRLSPFTVPSFLVNLAAGHVSIKHHFKGPIGAPVTACAAGVQAIGDAVRMIRNNEADVALCGGAEAVIDTVSLAGF 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 204 AAARALSQR-NDDPATASRPWDKDRDGFVLGEGAGVMVLEEYEHAKARGAKIYAEVSGYGMSADAYHMTAPVEDGDGARR 282
Cdd:PRK14691 131 AAARALSTHfNSTPEKASRPFDTARDGFVMGEGAGLLIIEELEHALARGAKPLAEIVGYGTSADAYHMTSGAEDGDGAYR 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 283 CMLAALRNAGVNPDEVNYLNAHGTSTQLGDLAETIGIKRAFGDrAKQMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQV 362
Cdd:PRK14691 211 AMKIALRQAGITPEQVQHLNAHATSTPVGDLGEINAIKHLFGE-SNALAITSTKSATGHLLGAAGGLETIFTVLALRDQI 289
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 738072904 363 SPPTINIFNQDPECD-LDYCANEARDMKIDVALKNSFGFGGTNGTLVFKR 411
Cdd:PRK14691 290 VPATLNLENPDPAAKgLNIIAGNAQPHDMTYALSNGFGFAGVNASILLKR 339
|
|
| PRK06501 |
PRK06501 |
beta-ketoacyl-ACP synthase; |
6-411 |
2.73e-91 |
|
beta-ketoacyl-ACP synthase;
Pssm-ID: 235817 [Multi-domain] Cd Length: 425 Bit Score: 281.90 E-value: 2.73e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 6 VVVTGLGLISPVGNNVADGWANLVAGRSGIANITKFDATNYSTRFAGEVKGFNVEEY----LPAKEARhmdtfihygiAA 81
Cdd:PRK06501 13 VAVTGMGVVTSLGQGKADNWAALTAGESGIHTITRFPTEGLRTRIAGTVDFLPESPFgasaLSEALAR----------LA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 82 GMQAMKDSGIE--------------VTEENAERFGVVVGSGIGGlpmiEVTQTELLNRGPRRISPFFVPASIINMISGHL 147
Cdd:PRK06501 83 AEEALAQAGIGkgdfpgplflaappVELEWPARFALAAAVGDND----APSYDRLLRAARGGRFDALHERFQFGSIADRL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 148 SIKFGLKGPNLAIVTACTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARALSQRNDDPATASRPWDKDR 227
Cdd:PRK06501 159 ADRFGTRGLPISLSTACASGATAIQLGVEAIRRGETDRALCIATDGSVSAEALIRFSLLSALSTQNDPPEKASKPFSKDR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 228 DGFVLGEGAGVMVLEEYEHAKARGAKIYAEVSGYGMSADAYHMTAPVEDGDGARRCMLAALRNAGVNPDEVNYLNAHGTS 307
Cdd:PRK06501 239 DGFVMAEGAGALVLESLESAVARGAKILGIVAGCGEKADSFHRTRSSPDGSPAIGAIRAALADAGLTPEQIDYINAHGTS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 308 TQLGDLAETIGIKRAFGDRAKQMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPECDLDYCANEARD 387
Cdd:PRK06501 319 TPENDKMEYLGLSAVFGERLASIPVSSNKSMIGHTLTAAGAVEAVFSLLTIQTGRLPPTINYDNPDPAIPLDVVPNVARD 398
|
410 420
....*....|....*....|....
gi 738072904 388 MKIDVALKNSFGFGGTNGTLVFKR 411
Cdd:PRK06501 399 ARVTAVLSNSFGFGGQNASLVLTA 422
|
|
| PRK09116 |
PRK09116 |
beta-ketoacyl-ACP synthase; |
4-410 |
1.75e-87 |
|
beta-ketoacyl-ACP synthase;
Pssm-ID: 181657 [Multi-domain] Cd Length: 405 Bit Score: 271.48 E-value: 1.75e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 4 RRVVVTGLGLISPVGNNVADGWANLVAGRSGIANIT---KFDATNysTRFAGEVKGFNVEEYLPAKEARHMDTFIHYGIA 80
Cdd:PRK09116 2 RRVVVTGMGGVTALGEDWQTIAARLKAGRNAVRRMPewdRYDGLN--TRLAAPIDDFELPAHYTRKKIRSMGRVSLMATR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 81 AGMQAMKDSGI--EVTEENAERFGVVVGSGIGGLPMIEVTqTELLNRGPRRISPffvpASIINMISgH-----LSIKFGL 153
Cdd:PRK09116 80 ASELALEDAGLlgDPILTDGRMGIAYGSSTGSTDPIGAFG-TMLLEGSMSGITA----TTYVRMMP-HttavnVGLFFGL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 154 KGPNLAIVTACTTGLHCIGEAARLIEYGDADLMIAGGAEAtVSPLGIGGFAAARALSQRNDDPATASRPWDKDRDGFVLG 233
Cdd:PRK09116 154 KGRVIPTSSACTSGSQGIGYAYEAIKYGYQTVMLAGGAEE-LCPTEAAVFDTLFATSTRNDAPELTPRPFDANRDGLVIG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 234 EGAGVMVLEEYEHAKARGAKIYAEVSGYGMSADAYHMTAPveDGDGARRCMLAALRNAGVNPDEVNYLNAHGTSTQLGDL 313
Cdd:PRK09116 233 EGAGTLVLEELEHAKARGATIYAEIVGFGTNSDGAHVTQP--QAETMQIAMELALKDAGLAPEDIGYVNAHGTATDRGDI 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 314 AETIGIKRAFGDRakqMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPEC-DLDYCANEARDMKIDV 392
Cdd:PRK09116 311 AESQATAAVFGAR---MPISSLKSYFGHTLGACGALEAWMSIEMMNEGWFAPTLNLTQVDPACgALDYIMGEAREIDTEY 387
|
410
....*....|....*...
gi 738072904 393 ALKNSFGFGGTNGTLVFK 410
Cdd:PRK09116 388 VMSNNFAFGGINTSLIFK 405
|
|
| PRK07910 |
PRK07910 |
beta-ketoacyl-ACP synthase; |
6-412 |
2.15e-87 |
|
beta-ketoacyl-ACP synthase;
Pssm-ID: 236129 [Multi-domain] Cd Length: 418 Bit Score: 271.60 E-value: 2.15e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 6 VVVTGLGLISPVGNNVADGWANLVAGRSGIANITK--FDATNYSTRFAGEVKGfNVEEYLPAKEARHMDTFIHYGIAAGM 83
Cdd:PRK07910 14 VVVTGIAMTTALATDAETTWKLLLDGQSGIRTLDDpfVEEFDLPVRIGGHLLE-EFDHQLTRVELRRMSYLQRMSTVLGR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 84 QAMKDSGieVTEENAERFGVVVGSGIGGLPMIEVTQTELLNRGPRRISPFFVPASIINMISGHLSIKFGLKGPNLAIVTA 163
Cdd:PRK07910 93 RVWENAG--SPEVDTNRLMVSIGTGLGSAEELVFAYDDMRARGLRAVSPLAVQMYMPNGPAAAVGLERHAKAGVITPVSA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 164 CTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARA-LSQRNDDPATASRPWDKDRDGFVLGEGAGVMVLE 242
Cdd:PRK07910 171 CASGSEAIAQAWRQIVLGEADIAICGGVETRIEAVPIAGFAQMRIvMSTNNDDPAGACRPFDKDRDGFVFGEGGALMVIE 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 243 EYEHAKARGAKIYAEVSGYGMSADAYHMTAPVEDGDGARRCMLAALRNAGVNPDEVNYLNAHGTSTQLGDLAETIGIKRA 322
Cdd:PRK07910 251 TEEHAKARGANILARIMGASITSDGFHMVAPDPNGERAGHAMTRAIELAGLTPGDIDHVNAHATGTSVGDVAEGKAINNA 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 323 FGdrAKQMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPECDLDYCANEARDMKIDVALKNSFGFGG 402
Cdd:PRK07910 331 LG--GHRPAVYAPKSALGHSVGAVGAVESILTVLALRDGVIPPTLNLENLDPEIDLDVVAGEPRPGNYRYAINNSFGFGG 408
|
410
....*....|
gi 738072904 403 TNGTLVFKRA 412
Cdd:PRK07910 409 HNVALAFGRY 418
|
|
| elong_cond_enzymes |
cd00828 |
"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, ... |
4-408 |
8.58e-73 |
|
"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as primer substrates, as well as the nature of their active site residues.
Pssm-ID: 238424 [Multi-domain] Cd Length: 407 Bit Score: 233.48 E-value: 8.58e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 4 RRVVVTGLGLISPVGNNVADG---WANLVAGRSGIANITKFDATnYSTRFAGEVKGFNVEEYLpAKEARHMDTFIHYGIA 80
Cdd:cd00828 1 SRVVITGIGVVSPHGEGCDEVeefWEALREGRSGIAPVARLKSR-FDRGVAGQIPTGDIPGWD-AKRTGIVDRTTLLALV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 81 AGMQAMKDSGIEV-TEENAERFGVVVGSGIGglpMIEVTQTELLNRGpRRISPFFVPASI--INMISGHLSIKFGLK-GP 156
Cdd:cd00828 79 ATEEALADAGITDpYEVHPSEVGVVVGSGMG---GLRFLRRGGKLDA-RAVNPYVSPKWMlsPNTVAGWVNILLLSShGP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 157 NLAIVTACTTGLHCIGEAARLIEYGDADLMIAGGAEATvSPLGIGGFAAARALSQRNDDPATASRPWDKDRDGFVLGEGA 236
Cdd:cd00828 155 IKTPVGACATALEALDLAVEAIRSGKADIVVVGGVEDP-LEEGLSGFANMGALSTAEEEPEEMSRPFDETRDGFVEAEGA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 237 GVMVLEEYEHAKARGAKIYAEVSGYGMSADAYHMTAPVeDGDGARRCMLAALRNAGVNPDEVNYLNAHGTSTQLGDLAET 316
Cdd:cd00828 234 GVLVLERAELALARGAPIYGRVAGTASTTDGAGRSVPA-GGKGIARAIRTALAKAGLSLDDLDVISAHGTSTPANDVAES 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 317 IGIKRAFGDRAKQMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPECDLDYCANEARD--MKIDVAL 394
Cdd:cd00828 313 RAIAEVAGALGAPLPVTAQKALFGHSKGAAGALQLIGALQSLEHGLIPPTANLDDVDPDVEHLSVVGLSRDlnLKVRAAL 392
|
410
....*....|....
gi 738072904 395 KNSFGFGGTNGTLV 408
Cdd:cd00828 393 VNAFGFGGSNAALV 406
|
|
| CLF |
cd00832 |
Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic ... |
4-408 |
4.70e-70 |
|
Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein (ACP). CLFs are similar to other elongation ketosynthase domains, but their active site cysteine is replaced by a conserved glutamine.
Pssm-ID: 238428 [Multi-domain] Cd Length: 399 Bit Score: 226.09 E-value: 4.70e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 4 RRVVVTGLGLISPVGNNVADGWANLVAGRSGIANITKFDATNYSTRFAGEVKGFNVEEYLPAKEARHMDTFIHYGIAAGM 83
Cdd:cd00832 1 RRAVVTGIGVVAPNGLGVEEYWKAVLDGRSGLGPITRFDPSGYPARLAGEVPDFDAAEHLPGRLLPQTDRMTRLALAAAD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 84 QAMKDSGIEVTEENAERFGVVVGSGIGGLpmiEVTQTELLN---RGPRRISPFFVPASIINMISGHLSIKFGLKGPNLAI 160
Cdd:cd00832 81 WALADAGVDPAALPPYDMGVVTASAAGGF---EFGQRELQKlwsKGPRHVSAYQSFAWFYAVNTGQISIRHGMRGPSGVV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 161 VTACTTGLHCIGEAARLIEYGdADLMIAGGAEATVSPLGIGGFAAARALSqRNDDPATASRPWDKDRDGFVLGEGAGVMV 240
Cdd:cd00832 158 VAEQAGGLDALAQARRLVRRG-TPLVVSGGVDSALCPWGWVAQLSSGRLS-TSDDPARAYLPFDAAAAGYVPGEGGAILV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 241 LEEYEHAKARGAKIYAEVSGYGMSADAyhmtAPVED-GDGARRCMLAALRNAGVNPDEVNYLNAHGTSTQLGDLAETIGI 319
Cdd:cd00832 236 LEDAAAARERGARVYGEIAGYAATFDP----PPGSGrPPGLARAIRLALADAGLTPEDVDVVFADAAGVPELDRAEAAAL 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 320 KRAFGDRAkqMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPECDLDYCANEARDMKIDVALKNSFG 399
Cdd:cd00832 312 AAVFGPRG--VPVTAPKTMTGRLYAGGAPLDVATALLALRDGVIPPTVNVTDVPPAYGLDLVTGRPRPAALRTALVLARG 389
|
....*....
gi 738072904 400 FGGTNGTLV 408
Cdd:cd00832 390 RGGFNSALV 398
|
|
| PRK05952 |
PRK05952 |
beta-ketoacyl-ACP synthase; |
5-411 |
1.17e-67 |
|
beta-ketoacyl-ACP synthase;
Pssm-ID: 235653 [Multi-domain] Cd Length: 381 Bit Score: 219.54 E-value: 1.17e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 5 RVVVTGLGLISPVGNnVADGWANLVAGRSGIANITKFdatnystrfaGEVKGFNVEeyLPAKEARHMDTFIHYGIAAgmq 84
Cdd:PRK05952 3 KVVVTGIGLVSALGD-LEQSWQRLLQGKSGIKLHQPF----------PELPPLPLG--LIGNQPSSLEDLTKTVVTA--- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 85 AMKDSGIEVTEENA--------------ERFGVVVGSGIGGLPMIEVTQtELLNRGPRRISpfFVPASIInmisghlsik 150
Cdd:PRK05952 67 ALKDAGLTPPLTDCgvvigssrgcqgqwEKLARQMYQGDDSPDEELDLE-NWLDTLPHQAA--IAAARQI---------- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 151 fGLKGPNLAIVTACTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARALSQrnddpaTASRPWDKDRDGF 230
Cdd:PRK05952 134 -GTQGPVLAPMAACATGLWAIAQGVELIQTGQCQRVIAGAVEAPITPLTLAGFQQMGALAK------TGAYPFDRQREGL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 231 VLGEGAGVMVLEEYEHAKARGAKIYAEVSGYGMSADAYHMTAPVEDGDGARRCMLAALRNAGVNPDEVNYLNAHGTSTQL 310
Cdd:PRK05952 207 VLGEGGAILVLESAELAQKRGAKIYGQILGFGLTCDAYHMSAPEPDGKSAIAAIQQCLARSGLTPEDIDYIHAHGTATRL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 311 GDLAETIGIKRAFGDRakqMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIfnQDPECDLDYcANEARDMKI 390
Cdd:PRK05952 287 NDQREANLIQALFPHR---VAVSSTKGATGHTLGASGALGVAFSLLALRHQQLPPCVGL--QEPEFDLNF-VRQAQQSPL 360
|
410 420
....*....|....*....|.
gi 738072904 391 DVALKNSFGFGGTNGTLVFKR 411
Cdd:PRK05952 361 QNVLCLSFGFGGQNAAIALGK 381
|
|
| PRK07103 |
PRK07103 |
polyketide beta-ketoacyl:acyl carrier protein synthase; Validated |
5-411 |
1.40e-57 |
|
polyketide beta-ketoacyl:acyl carrier protein synthase; Validated
Pssm-ID: 180839 [Multi-domain] Cd Length: 410 Bit Score: 194.09 E-value: 1.40e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 5 RVVVTGLGLISPVGNNVADGWANLVAGRSGI--------ANITKFDATNYSTRFAGEVKGFNVEEYLPAKEARHMDTFIH 76
Cdd:PRK07103 3 EVVVTGVGVVSAIGQGRPSFAAALLAGRHAFgvmrrpgrQVPDDAGAGLASAFIGAELDSLALPERLDAKLLRRASLSAQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 77 YGIAAGMQAMKDS----------GIEVTEENaerfgvvvgsgigglpmieVTQTELLNRGPR-RISPFFVPASII----- 140
Cdd:PRK07103 83 AALAAAREAWRDAalgpvdpdriGLVVGGSN-------------------LQQREQALVHETyRDRPAFLRPSYGlsfmd 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 141 NMISGHLSIKFGLKGPNLAIVTACTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARAL-SQRN-DDPAT 218
Cdd:PRK07103 144 TDLVGLCSEQFGIRGEGFTVGGASASGQLAVIQAARLVQSGSVDACIAVGALMDLSYWECQALRSLGAMgSDRFaDEPEA 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 219 ASRPWDKDRDGFVLGEGAGVMVLEEYEHAKARGAKIYAEVSGYGMSADAYHMTAPveDGDGARRCMLAALRNAGVNPDEV 298
Cdd:PRK07103 224 ACRPFDQDRDGFIYGEACGAVVLESAESARRRGARPYAKLLGWSMRLDANRGPDP--SLEGEMRVIRAALRRAGLGPEDI 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 299 NYLNAHGTSTQLGDLAEtigIKRAFGDRAKQMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQ-DPECd 377
Cdd:PRK07103 302 DYVNPHGTGSPLGDETE---LAALFASGLAHAWINATKSLTGHGLSAAGIVELIATLLQMRAGFLHPSRNLDEPiDERF- 377
|
410 420 430
....*....|....*....|....*....|....
gi 738072904 378 lDYCANEARDMKIDVALKNSFGFGGTNGTLVFKR 411
Cdd:PRK07103 378 -RWVGSTAESARIRYALSLSFGFGGINTALVLER 410
|
|
| ketoacyl-synt |
pfam00109 |
Beta-ketoacyl synthase, N-terminal domain; The structure of beta-ketoacyl synthase is similar ... |
4-247 |
4.48e-57 |
|
Beta-ketoacyl synthase, N-terminal domain; The structure of beta-ketoacyl synthase is similar to that of the thiolase family (pfam00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains most of the structures involved in dimer formation and also the active site cysteine.
Pssm-ID: 425468 [Multi-domain] Cd Length: 251 Bit Score: 187.84 E-value: 4.48e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 4 RRVVVTGLGLISPVGNNVADGWANLVAGRSGIANI--TKFDATNY---STRFAGEVKG--------FNVEEYL---PAKE 67
Cdd:pfam00109 1 EPVAIVGMGCRFPGGNDPEEFWENLLEGRDGISEIpaDRWDPDKLydpPSRIAGKIYTkwgglddiFDFDPLFfgiSPRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 68 ARHMDTFIHYGIAAGMQAMKDSGIEVTEENAERFGVVVGSGIGGLpmiEVTQTELLNRGPRRISPFFVPAsIINMISGHL 147
Cdd:pfam00109 81 AERMDPQQRLLLEAAWEALEDAGITPDSLDGSRTGVFIGSGIGDY---AALLLLDEDGGPRRGSPFAVGT-MPSVIAGRI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 148 SIKFGLKGPNLAIVTACTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARALSQrnDDPATASRPWDkdr 227
Cdd:pfam00109 157 SYFLGLRGPSVTVDTACSSSLVAIHAAVQSIRSGEADVALAGGVNLLLTPLGFAGFSAAGMLSP--DGPCKAFDPFA--- 231
|
250 260
....*....|....*....|
gi 738072904 228 DGFVLGEGAGVMVLEEYEHA 247
Cdd:pfam00109 232 DGFVRGEGVGAVVLKRLSDA 251
|
|
| PRK09185 |
PRK09185 |
beta-ketoacyl-ACP synthase; |
151-412 |
7.75e-57 |
|
beta-ketoacyl-ACP synthase;
Pssm-ID: 236398 [Multi-domain] Cd Length: 392 Bit Score: 191.59 E-value: 7.75e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 151 FGLKGPNLAIVTACTTGLHCIGEAARLIEYGDADLMIAGGAEaTVSPLGIGGFAAARALSqrnddpATASRPWDKDRDGF 230
Cdd:PRK09185 147 LGLSGPAYTISTACSSSAKVFASARRLLEAGLCDAAIVGGVD-SLCRLTLNGFNSLESLS------PQPCRPFSANRDGI 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 231 VLGEGAGVMVLEeyehakaRGAKIYAEVSGYGMSADAYHMTAPVEDGDGARRCMLAALRNAGVNPDEVNYLNAHGTSTQL 310
Cdd:PRK09185 220 NIGEAAAFFLLE-------REDDAAVALLGVGESSDAHHMSAPHPEGLGAILAMQQALADAGLAPADIGYINLHGTATPL 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 311 GDLAETIGIKRAFGDRakqMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPECDLDYCANEARDMKI 390
Cdd:PRK09185 293 NDAMESRAVAAVFGDG---VPCSSTKGLTGHTLGAAGAVEAAICWLALRHGLPPHGWNTGQPDPALPPLYLVENAQALAI 369
|
250 260
....*....|....*....|..
gi 738072904 391 DVALKNSFGFGGTNGTLVFKRA 412
Cdd:PRK09185 370 RYVLSNSFAFGGNNCSLIFGRA 391
|
|
| PKS |
cd00833 |
polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different ... |
5-408 |
4.66e-56 |
|
polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or more large multifunctional proteins and iterative type II PKSs, complexes of several monofunctional subunits.
Pssm-ID: 238429 [Multi-domain] Cd Length: 421 Bit Score: 190.08 E-value: 4.66e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 5 RVVVTGLGLISPVGNNVADGWANLVAGRSGIANITK--FDATNYS----------TRFAG---EVKGFNVEEY-LPAKEA 68
Cdd:cd00833 2 PIAIVGMACRFPGAADPDEFWENLLEGRDAISEIPEdrWDADGYYpdpgkpgktyTRRGGfldDVDAFDAAFFgISPREA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 69 RHMD------------TFIHYGIAAGMQAMKDSGIEVTEENAERfgvvvgsgigglpmievtqTELLNRGPRRISPFFVP 136
Cdd:cd00833 82 EAMDpqqrlllevaweALEDAGYSPESLAGSRTGVFVGASSSDY-------------------LELLARDPDEIDAYAAT 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 137 ASIINMISGHLSIKFGLKGPNLAIVTACTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARALSqrnddP 216
Cdd:cd00833 143 GTSRAFLANRISYFFDLRGPSLTVDTACSSSLVALHLACQSLRSGECDLALVGGVNLILSPDMFVGFSKAGMLS-----P 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 217 ATASRPWDKDRDGFVLGEGAGVMVLEEYEHAKARGAKIYAEVSGYGMSADAY--HMTAPveDGDGARRCMLAALRNAGVN 294
Cdd:cd00833 218 DGRCRPFDADADGYVRGEGVGVVVLKRLSDALRDGDRIYAVIRGSAVNQDGRtkGITAP--SGEAQAALIRRAYARAGVD 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 295 PDEVNYLNAHGTSTQLGDLAETIGIKRAFGDRAKQM---VVNSTKS----------MTghllggaggleSVF-TVLAVHN 360
Cdd:cd00833 296 PSDIDYVEAHGTGTPLGDPIEVEALAKVFGGSRSADqplLIGSVKSnighleaaagLA-----------GLIkVVLALEH 364
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 738072904 361 QVSPPTINIFNQDPECDLDYCANEARDMKID--------VALKNSFGFGGTNGTLV 408
Cdd:cd00833 365 GVIPPNLHFETPNPKIDFEESPLRVPTEARPwpapagprRAGVSSFGFGGTNAHVI 420
|
|
| decarbox_cond_enzymes |
cd00825 |
decarboxylating condensing enzymes; Family of enzymes that catalyze the formation of a new ... |
76-408 |
7.68e-51 |
|
decarboxylating condensing enzymes; Family of enzymes that catalyze the formation of a new carbon-carbon bond by a decarboxylating Claisen-like condensation reaction. Members are involved in the synthesis of fatty acids and polyketides, a diverse group of natural products. Both pathways are an iterative series of additions of small carbon units, usually acetate, to a nascent acyl group. There are 2 classes of decarboxylating condensing enzymes, which can be distinguished by sequence similarity, type of active site residues and type of primer units (acetyl CoA or acyl carrier protein (ACP) linked units).
Pssm-ID: 238421 [Multi-domain] Cd Length: 332 Bit Score: 173.98 E-value: 7.68e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 76 HYGIAAGMQAMKDSGIEVTEENAERFGVVVGSGIGGLPMIEVTQTELLNRGPRRISPFFVPASiinmiSGHLSIKFGLKG 155
Cdd:cd00825 13 ILGFEAAERAIADAGLSREYQKNPIVGVVVGTGGGSPRFQVFGADAMRAVGPYVVTKAMFPGA-----SGQIATPLGIHG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 156 PNLAIVTACTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARALSqrnddPATASRPWDKDRDGFVLGEG 235
Cdd:cd00825 88 PAYDVSAACAGSLHALSLAADAVQNGKQDIVLAGGSEELAAPMDCEFDAMGALST-----PEKASRTFDAAADGFVFGDG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 236 AGVMVLEEYEHAKARGAKIYAEVSGYGMSADAYHMTAPVEDGDGARRCMLAALRNAGVNPDEVNYLNAHGTSTQLGDLAE 315
Cdd:cd00825 163 AGALVVEELEHALARGAHIYAEIVGTAATIDGAGMGAFAPSAEGLARAAKEALAVAGLTVWDIDYLVAHGTGTPIGDVKE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 316 TIGIKRAFGDRakQMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQDPecDLDYCANEARDMKIDVALK 395
Cdd:cd00825 243 LKLLRSEFGDK--SPAVSATKAMTGNLSSAAVVLAVDEAVLMLEHGFIPPSIHIEELDE--AGLNIVTETTPRELRTALL 318
|
330
....*....|...
gi 738072904 396 NSFGFGGTNGTLV 408
Cdd:cd00825 319 NGFGLGGTNATLV 331
|
|
| PksD |
COG3321 |
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ... |
1-404 |
9.63e-44 |
|
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 442550 [Multi-domain] Cd Length: 1386 Bit Score: 163.50 E-value: 9.63e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 1 MSRRRVVVTGLGLISPVGNNVADGWANLVAGRSGIANITK--------FDA------TNYSTR--FAGEVKGFNVEEY-L 63
Cdd:COG3321 1 AADEPIAIIGMACRFPGADDPEEFWRNLRAGRDAITEVPAdrwdadayYDPdpdapgKTYVRWggFLDDVDEFDALFFgI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 64 PAKEARHMDtfihygiaagMQ----------AMKDSGIEVTEENAER---FgvvvgsgigglpmIEVTQTE---LLNRGP 127
Cdd:COG3321 81 SPREAEAMD----------PQqrlllevaweALEDAGYDPESLAGSRtgvF-------------VGASSNDyalLLLADP 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 128 RRISPFFVPASIINMISGHLSIKFGLKGPNLAIVTACTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAAR 207
Cdd:COG3321 138 EAIDAYALTGNAKSVLAGRISYKLDLRGPSVTVDTACSSSLVAVHLACQSLRSGECDLALAGGVNLMLTPESFILFSKGG 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 208 ALSqrnddPATASRPWDKDRDGFVLGEGAGVMVLEEYEHAKARGAKIYAEVSGYGMSAD-AYH-MTAPveDGDGARRCML 285
Cdd:COG3321 218 MLS-----PDGRCRAFDADADGYVRGEGVGVVVLKRLSDALRDGDRIYAVIRGSAVNQDgRSNgLTAP--NGPAQAAVIR 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 286 AALRNAGVNPDEVNYLNAHGTSTQLGDLAETIGIKRAFG-DRAKQ--MVVNSTKSMtghllggagglesvF--------- 353
Cdd:COG3321 291 RALADAGVDPATVDYVEAHGTGTPLGDPIEAAALTAAFGqGRPADqpCAIGSVKSN--------------Ighleaaagv 356
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 738072904 354 -----TVLAVHNQVSPPTINiFNQ-DPECDLD----YCANEARDMKID----VALKNSFGFGGTN 404
Cdd:COG3321 357 aglikAVLALRHGVLPPTLH-FETpNPHIDFEnspfYVNTELRPWPAGggprRAGVSSFGFGGTN 420
|
|
| Ketoacyl-synt_C |
pfam02801 |
Beta-ketoacyl synthase, C-terminal domain; The structure of beta-ketoacyl synthase is similar ... |
255-369 |
1.50e-35 |
|
Beta-ketoacyl synthase, C-terminal domain; The structure of beta-ketoacyl synthase is similar to that of the thiolase family (pfam00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.
Pssm-ID: 426989 Cd Length: 118 Bit Score: 126.91 E-value: 1.50e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 255 YAEVSGYGMSADAYHMTAPVEDGDGARRCMLAALRNAGVNPDEVNYLNAHGTSTQLGDLAETIGIKRAFGDRAKQ--MVV 332
Cdd:pfam02801 1 YAVIKGSAVNHDGRHNGLTAPNGEGQARAIRRALADAGVDPEDVDYVEAHGTGTPLGDPIEAEALKRVFGSGARKqpLAI 80
|
90 100 110
....*....|....*....|....*....|....*..
gi 738072904 333 NSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINI 369
Cdd:pfam02801 81 GSVKSNIGHLEGAAGAAGLIKVVLALRHGVIPPTLNL 117
|
|
| omega_3_PfaA |
TIGR02813 |
polyketide-type polyunsaturated fatty acid synthase PfaA; Members of the seed for this ... |
136-410 |
4.97e-34 |
|
polyketide-type polyunsaturated fatty acid synthase PfaA; Members of the seed for this alignment are involved in omega-3 polyunsaturated fatty acid biosynthesis, such as the protein PfaA from the eicosapentaenoic acid biosynthesis operon in Photobacterium profundum strain SS9. PfaA is encoded together with PfaB, PfaC, and PfaD, and the functions of the individual polypeptides have not yet been described. More distant homologs of PfaA, also included with the reach of this model, appear to be involved in polyketide-like biosynthetic mechanisms of polyunsaturated fatty acid biosynthesis, an alternative to the more familiar iterated mechanism of chain extension and desaturation, and in most cases are encoded near genes for homologs of PfaB, PfaC, and/or PfaD.
Pssm-ID: 274311 [Multi-domain] Cd Length: 2582 Bit Score: 135.13 E-value: 4.97e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 136 PASIINMISGHLSIKFGLKGPNLAIVTACTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARALSQRNDd 215
Cdd:TIGR02813 178 PGSLGNVISGRIANRFDLGGMNCVVDAACAGSLAAIRMALSELLEGRSEMMITGGVCTDNSPFMYMSFSKTPAFTTNED- 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 216 pataSRPWDKDRDGFVLGEGAGVMVLEEYEHAKARGAKIYAEVSGYGMSADAYHMTAPVEDGDGARRCMLAALRNAGVNP 295
Cdd:TIGR02813 257 ----IQPFDIDSKGMMIGEGIGMMALKRLEDAERDGDRIYAVIKGVGASSDGKFKSIYAPRPEGQAKALKRAYDDAGFAP 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 296 DEVNYLNAHGTSTQLGDLAETIGIKRAFG---DRAKQMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTINIFNQ 372
Cdd:TIGR02813 333 HTCGLIEAHGTGTAAGDVAEFGGLVSVFSqdnDQKQHIALGSVKSQIGHTKSTAGTAGMIKAVLALHHKVLPPTINVDQP 412
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 738072904 373 DPECDLD----YCANEAR------DMKIDVALKNSFGFGGTNGTLVFK 410
Cdd:TIGR02813 413 NPKLDIEnspfYLNTETRpwmqreDGTPRRAGISSFGFGGTNFHMVLE 460
|
|
| cond_enzymes |
cd00327 |
Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) ... |
144-408 |
3.91e-24 |
|
Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the production of polyketides, a diverse group of natural products.
Pssm-ID: 238201 [Multi-domain] Cd Length: 254 Bit Score: 100.21 E-value: 3.91e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 144 SGHLSIKFGLK-GPNLAIVTACTTGLHCIGEAARLIEYGDADLMIAGGAEAtvsplgiggfaaaralsqrnddpatasrp 222
Cdd:cd00327 47 AGQLAYHLGISgGPAYSVNQACATGLTALALAVQQVQNGKADIVLAGGSEE----------------------------- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 223 wdkdrdgFVLGEGAGVMVLEEYEHAKARGAKIYAEVSGYGMSAD-AYHMTAPVedGDGARRCMLAALRNAGVNPDEVNYL 301
Cdd:cd00327 98 -------FVFGDGAAAAVVESEEHALRRGAHPQAEIVSTAATFDgASMVPAVS--GEGLARAARKALEGAGLTPSDIDYV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 302 NAHGTSTQLGDLAETIGIKRAFGDRAkqMVVNSTKSMTGHLLGGAGGLESVFTVLAVHNQVSPPTinifNQDPECdldyc 381
Cdd:cd00327 169 EAHGTGTPIGDAVELALGLDPDGVRS--PAVSATLIMTGHPLGAAGLAILDELLLMLEHEFIPPT----PREPRT----- 237
|
250 260
....*....|....*....|....*..
gi 738072904 382 aneardmkidvALKNSFGFGGTNGTLV 408
Cdd:cd00327 238 -----------VLLLGFGLGGTNAAVV 253
|
|
| PKS_KS |
smart00825 |
Beta-ketoacyl synthase; The structure of beta-ketoacyl synthase is similar to that of the ... |
158-408 |
1.25e-14 |
|
Beta-ketoacyl synthase; The structure of beta-ketoacyl synthase is similar to that of the thiolase family and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.
Pssm-ID: 214836 [Multi-domain] Cd Length: 298 Bit Score: 73.90 E-value: 1.25e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 158 LAIVTACTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARALSqrnddPATASRPWDKDRDGFVLGEGAG 237
Cdd:smart00825 91 VTVDTACSSSLVALHLACQSLRSGECDMALAGGVNLILSPDTFVGLSRAGMLS-----PDGRCKTFDASADGYVRGEGVG 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 238 VMVLEEYEHAKARGAKIYAEVSGYGMSADAYH--MTAPvedgDGARRCML-----------AAlrnAGVnpdevnylnah 304
Cdd:smart00825 166 VVVLKRLSDALRDGDPILAVIRGSAVNQDGRSngITAP----SGPAQLLIgsvksnighleAA---AGV----------- 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 305 gtsTQLgdlaetigIKrafgdrakqmvvnstksmtghllggagglesvfTVLAVHNQVSPPTINIFNQDPECDLD----Y 380
Cdd:smart00825 228 ---AGL--------IK---------------------------------VVLALKHGVIPPTLHFETPNPHIDLEesplR 263
|
250 260 270
....*....|....*....|....*....|..
gi 738072904 381 CANEARDMKID----VALKNSFGFGGTNGTLV 408
Cdd:smart00825 264 VPTELTPWPPPgrprRAGVSSFGFGGTNAHVI 295
|
|
| PRK06147 |
PRK06147 |
3-oxoacyl-(acyl carrier protein) synthase; Validated |
4-300 |
6.73e-10 |
|
3-oxoacyl-(acyl carrier protein) synthase; Validated
Pssm-ID: 235715 [Multi-domain] Cd Length: 348 Bit Score: 60.03 E-value: 6.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 4 RRVVVTGLGLISPVGnnvADGWANLVAGRSGIANITKfdatnysTRFAGEVKGfnveEYLPAKEARHMDTFIHYGIAAGM 83
Cdd:PRK06147 3 RALAIVGSGMVTAVG---LDAPSSCAAIRARLDNFQE-------TRFIDPPGG----EWLIGAPVPLPPPWRGPERLAEM 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 84 QAMkdsgieVTEENAErfgvvvgsgigGLPMIEVTQTELLNRGP---RRISPFFVPASIINMISGHLSIKFGlkgPNLAI 160
Cdd:PRK06147 69 AAP------AIAEALE-----------GLPALDASEAPLLLCVAeeeRPGRPPDLEERLLRELEARLGLRLE---PGSAV 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 161 VTACTTGLHC-IGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARALsqrnddpATASRPwdkdrDGFVLGEGAGVM 239
Cdd:PRK06147 129 IARGRVSGAVaLAQARRLIAAGGCPRVLVAGVDSLLTGPTLAHYEARDRL-------LTSQNS-----NGFIPGEAAAAV 196
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 738072904 240 VLEEYEHAKARGAKIYaevsGYGMSADAyhmtAPVED-------GDGARRCMLAALRNAGVNPDEVNY 300
Cdd:PRK06147 197 LLGRPAGGEAPGLPLL----GLGLGREP----APVGEsedlplrGDGLTQAIRAALAEAGCGLEDMDY 256
|
|
| PRK06519 |
PRK06519 |
beta-ketoacyl-ACP synthase; |
1-260 |
1.05e-08 |
|
beta-ketoacyl-ACP synthase;
Pssm-ID: 235819 [Multi-domain] Cd Length: 398 Bit Score: 56.50 E-value: 1.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 1 MSRRRVVVTGLGLISPVGNNVADGWANLvAGRSGIANItkfDATNYSTRFAGEVKGFNVEEYLPAK-EARHMDTFIHYGI 79
Cdd:PRK06519 3 MQPNDVVITGIGLVSSLGEGLDAHWNAL-SAGRPQPNV---DTETFAPYPVHPLPEIDWSQQIPKRgDQRQMETWQRLGT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 80 -AAGMqAMKDSGIEVTEE------------NAER--------FGVVVGSGIGGLPMIEVTQTELlnrgprRISPFFVPAS 138
Cdd:PRK06519 79 yAAGL-ALDDAGIKGNEEllstmdmivaagGGERdiavdtaiLNEARKRNDRGVLLNERLMTEL------RPTLFLAQLS 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738072904 139 iiNMISGHLSIKFGLKGPNLAIVTACTTGLHCIGEAARLIEYGDADLMIAGGAEATVSPLGIGGFAAARALSQRNDDPAT 218
Cdd:PRK06519 152 --NLLAGNISIVHKVTGSSRTFMGEESAGVSAIEIAFARIASGQSDHALVGGAYNAERPDMLLLYELGGLLLKGGWAPVW 229
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 738072904 219 ASRPWDKDrdGFVLGEGAGVMVLEEYEHAKARGAKIYAEVSG 260
Cdd:PRK06519 230 SRGGEDGG--GFILGSGGAFLVLESREHAEARGARPYARISG 269
|
|
| PaaJ |
COG0183 |
Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is ... |
163-236 |
3.96e-05 |
|
Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is part of the Pathway/BioSystem: Fatty acid biosynthesis
Pssm-ID: 439953 [Multi-domain] Cd Length: 391 Bit Score: 45.44 E-value: 3.96e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 738072904 163 ACTTGLHCIGEAARLIEYGDADLMIAGGAEA-TVSPLGIGGFAAARALSQRNDDPATASRPWDkDRDGFVLGEGA 236
Cdd:COG0183 87 VCGSGLQAVALAAQAIAAGDADVVIAGGVESmSRAPMLLPKARWGYRMNAKLVDPMINPGLTD-PYTGLSMGETA 160
|
|
| PRK09050 |
PRK09050 |
beta-ketoadipyl CoA thiolase; Validated |
164-192 |
6.09e-04 |
|
beta-ketoadipyl CoA thiolase; Validated
Pssm-ID: 181624 [Multi-domain] Cd Length: 401 Bit Score: 41.86 E-value: 6.09e-04
10 20
....*....|....*....|....*....
gi 738072904 164 CTTGLHCIGEAARLIEYGDADLMIAGGAE 192
Cdd:PRK09050 90 CGSGMDAVGTAARAIKAGEAELMIAGGVE 118
|
|
| thiolase |
cd00751 |
Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of ... |
163-192 |
4.74e-03 |
|
Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.
Pssm-ID: 238383 [Multi-domain] Cd Length: 386 Bit Score: 39.00 E-value: 4.74e-03
10 20 30
....*....|....*....|....*....|
gi 738072904 163 ACTTGLHCIGEAARLIEYGDADLMIAGGAE 192
Cdd:cd00751 83 VCGSGLQAVALAAQSIAAGEADVVVAGGVE 112
|
|
| |
