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Conserved domains on  [gi|738079293|ref|WP_036038082|]
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dehydrogenase [Burkholderia gladioli]

Protein Classification

COG2605 family protein( domain architecture ID 11457575)

COG2605 family protein

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 13-349 1.57e-148

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


:

Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 421.51  E-value: 1.57e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293  13 VRARAPLRLGLAGGGTDVSPYSDDFGGLVLNATINRYAYATLAPRQDDRVELVAADsavswqgsmassLGLVK----GLE 88
Cdd:COG2605    1 IISRAPLRISFAGGGTDLPPYYLEHGGAVLNAAIDKYAYVTLEPRFDGKIRLSSSD------------TERVEtvdeDDD 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293  89 LHVGVYNRIVRDYHGGQPLavQITTHSEAPPGSGLGSSSTMVVALLHAFVEYLQIPLGEYEIAQLAYEIERVDLAFAGGK 168
Cdd:COG2605   69 IPHPVIREALKLFGIGDGL--EITTDSDAPAGSGLGSSSALTVALLNALHALLGLPLSPYDLARLAYEIERNDLGEPGGK 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293 169 QDQYAAAFGGFNFMEFDKD-RVIVNPLRVKQSVLAELESSLVLFYTGVSRESAKIIEEQTNSMRRGNFASVEAMHRVKQE 247
Cdd:COG2605  147 QDQYAAAFGGFNFIEFGPDgRVIVNPLRISPEILNELESNLLLFYTGITRESSDILKEQVKNVEDGDEATLEALHEMKEL 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293 248 AVRMKEAILKGDFDSFAESMRLSWEAKKKMASSISNATIDAIYDAAIAAGALAGKVSGAGGGGFMMFIVDPTRRPGVIRA 327
Cdd:COG2605  227 ALEMKEALLKGDLDEFGELLNEGWELKKRLASGISNPAIDEIYELARKAGALGGKLLGAGGGGFLLFYAPPERREAVREA 306

                        330       340
                 ....*....|....*....|..
gi 738079293 328 LGGFDGQVLTCNFTKHGAYSWR 349
Cdd:COG2605  307 LSKAGLRVVPFSFDKEGSQVWR 328
 
Name Accession Description Interval E-value
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 13-349 1.57e-148

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 421.51  E-value: 1.57e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293  13 VRARAPLRLGLAGGGTDVSPYSDDFGGLVLNATINRYAYATLAPRQDDRVELVAADsavswqgsmassLGLVK----GLE 88
Cdd:COG2605    1 IISRAPLRISFAGGGTDLPPYYLEHGGAVLNAAIDKYAYVTLEPRFDGKIRLSSSD------------TERVEtvdeDDD 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293  89 LHVGVYNRIVRDYHGGQPLavQITTHSEAPPGSGLGSSSTMVVALLHAFVEYLQIPLGEYEIAQLAYEIERVDLAFAGGK 168
Cdd:COG2605   69 IPHPVIREALKLFGIGDGL--EITTDSDAPAGSGLGSSSALTVALLNALHALLGLPLSPYDLARLAYEIERNDLGEPGGK 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293 169 QDQYAAAFGGFNFMEFDKD-RVIVNPLRVKQSVLAELESSLVLFYTGVSRESAKIIEEQTNSMRRGNFASVEAMHRVKQE 247
Cdd:COG2605  147 QDQYAAAFGGFNFIEFGPDgRVIVNPLRISPEILNELESNLLLFYTGITRESSDILKEQVKNVEDGDEATLEALHEMKEL 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293 248 AVRMKEAILKGDFDSFAESMRLSWEAKKKMASSISNATIDAIYDAAIAAGALAGKVSGAGGGGFMMFIVDPTRRPGVIRA 327
Cdd:COG2605  227 ALEMKEALLKGDLDEFGELLNEGWELKKRLASGISNPAIDEIYELARKAGALGGKLLGAGGGGFLLFYAPPERREAVREA 306

                        330       340
                 ....*....|....*....|..
gi 738079293 328 LGGFDGQVLTCNFTKHGAYSWR 349
Cdd:COG2605  307 LSKAGLRVVPFSFDKEGSQVWR 328
fkp PRK13412
bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional
 9-284 1.10e-24

bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional


Pssm-ID: 237379 [Multi-domain]  Cd Length: 974  Bit Score: 105.30  E-value: 1.10e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293   9 RRELVRARAPLRLGLAGGGTDVSPYSDDFGGLVLNATINRYA----YATLAPRQDDRVELVAADsavswQGSMA------ 78
Cdd:PRK13412 606 SDQIVWGRSPVRIDLAGGWTDTPPYCLYSGGNVVNLAIELNGqpplQVYVKPCSEPHIVLRSID-----LGAMEvvrtne 680

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293  79 ---------SSLGLVKGLELHVGVYNRIVRDYHGG--QPLA-----VQITTHSEAPPGSGLGSSSTMVVALLHAFVEYLQ 142
Cdd:PRK13412 681 elrdykkvgSPFSIPKAALCLAGFAPRFSAESYASleEQLKafgsgIEITLLAAIPAGSGLGTSSILAATVLGAISDFCG 760

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293 143 IPLGEYEIAQLAYEIERVdLAFAGGKQDQYAAAFGGFNFME----FDKdRVIVNPLRVKQSVLAELESSLVLFYTGVSRE 218
Cdd:PRK13412 761 LAWDKNEICNRTLVLEQL-LTTGGGWQDQYGGVLPGVKLLQtgagFAQ-SPLVRWLPDSLFTQPEYRDCHLLYYTGITRT 838

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738079293 219 SAKIIEEQTNSMRRGNFASVEAMHRVKQEAVRMKEAILKGDFDSFAESMRLSWEAKKKMASSISNA 284
Cdd:PRK13412 839 AKGILAEIVRSMFLNSTAHLQLLHEMKAHALDMYEAIQRGEFEEFGRLVGKTWEQNKALDSGTNPA 904
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 37-269 4.68e-16

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 76.95  E-value: 4.68e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293   37 FGGLVLNATINRYAYATLAPRQDDrvelVAADSAVSWQGsmassLGLVK-GLELHVGVYNRIVRDYHGGQPLAVQITTHS 115
Cdd:TIGR00549  15 YGEPAIAAPIPLRTTVTVIESSDG----SFIESDLGRGS-----LDDAPdELDGLKYVLAEFLSRFSELNPPPLEITIES 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293  116 EAPPGSGLGSSSTMVVALLHAFVEYLQIPLGEYEIAQLAYEIERVdlafAGGKQ---DQYAAAFGGFNFmeFDKDrvivn 192
Cdd:TIGR00549  86 EIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKI----AHGKPsgiDTATSTSGGPVY--FEKG----- 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 738079293  193 plRVKQSVLAELESSLVLFYTGVSRESAKIIEEQTNSMRRGNFASVEAMHRVKQEAVRMKEAILKGDFDSFAESMRL 269
Cdd:TIGR00549 155 --EGEFTKLISLDGYFVIADTGVSGSTKEAVARVRQLLERFPELIDSIMDAIGELTLEAKAALQDGDVESLGELMNI 229
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 111-178 7.65e-13

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 62.57  E-value: 7.65e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 738079293  111 ITTHSEAPPGSGLGSSSTMVVALLHAFVEYLQIPLgeyeiAQLAYEIERVDLAFAGGKQDQYAAAFGG 178
Cdd:pfam00288   2 IEIESNIPLGAGLGSSAALAVALLLALNELFGLPL-----AKLALEAEELAGGGRGGGMDVAASLYGG 64
 
Name Accession Description Interval E-value
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 13-349 1.57e-148

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 421.51  E-value: 1.57e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293  13 VRARAPLRLGLAGGGTDVSPYSDDFGGLVLNATINRYAYATLAPRQDDRVELVAADsavswqgsmassLGLVK----GLE 88
Cdd:COG2605    1 IISRAPLRISFAGGGTDLPPYYLEHGGAVLNAAIDKYAYVTLEPRFDGKIRLSSSD------------TERVEtvdeDDD 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293  89 LHVGVYNRIVRDYHGGQPLavQITTHSEAPPGSGLGSSSTMVVALLHAFVEYLQIPLGEYEIAQLAYEIERVDLAFAGGK 168
Cdd:COG2605   69 IPHPVIREALKLFGIGDGL--EITTDSDAPAGSGLGSSSALTVALLNALHALLGLPLSPYDLARLAYEIERNDLGEPGGK 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293 169 QDQYAAAFGGFNFMEFDKD-RVIVNPLRVKQSVLAELESSLVLFYTGVSRESAKIIEEQTNSMRRGNFASVEAMHRVKQE 247
Cdd:COG2605  147 QDQYAAAFGGFNFIEFGPDgRVIVNPLRISPEILNELESNLLLFYTGITRESSDILKEQVKNVEDGDEATLEALHEMKEL 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293 248 AVRMKEAILKGDFDSFAESMRLSWEAKKKMASSISNATIDAIYDAAIAAGALAGKVSGAGGGGFMMFIVDPTRRPGVIRA 327
Cdd:COG2605  227 ALEMKEALLKGDLDEFGELLNEGWELKKRLASGISNPAIDEIYELARKAGALGGKLLGAGGGGFLLFYAPPERREAVREA 306

                        330       340
                 ....*....|....*....|..
gi 738079293 328 LGGFDGQVLTCNFTKHGAYSWR 349
Cdd:COG2605  307 LSKAGLRVVPFSFDKEGSQVWR 328
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 17-268 2.08e-26

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 106.08  E-value: 2.08e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293  17 APLRLGLAGGgtdvspYSDDFGGLVLNATINRYAYATLAPRQDDRVELVAADSAVSW--QGSMASSLGLVKGLeLhvgvy 94
Cdd:COG1577    1 APGKLILFGE------HAVVYGQPAIAVAVDRRATVTVEPSDDDKLRIESPDLGGTLdlDPLADAALRYIKAA-I----- 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293  95 nRIVRDYHGGQPLAVQITTHSEAPPGSGLGSSSTMVVALLHAFVEYLQIPLGEYEIAQLAYEIERVdlafAGGK---QDQ 171
Cdd:COG1577   69 -EAALEYLGLPLKGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAAFYGVELSKEELFKLALEAEKI----VHGNpsgLDT 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293 172 YAAAFGGfnFMEFDKDRvIVNPLRVKQSVlaelesSLVLFYTGVSRESAKIIEEQTNSMRRGNFASVEAMHRVKQEAVRM 251
Cdd:COG1577  144 AASTYGG--PIYYQRGD-RAEPLELPKNL------PLVVGDTGVPASTKELVAKVRKLKERNPELYEAFLEEIGDLVEEA 214

                        250
                 ....*....|....*..
gi 738079293 252 KEAILKGDFDSFAESMR 268
Cdd:COG1577  215 IEALEEGDLEALGELMN 231
fkp PRK13412
bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional
 9-284 1.10e-24

bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional


Pssm-ID: 237379 [Multi-domain]  Cd Length: 974  Bit Score: 105.30  E-value: 1.10e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293   9 RRELVRARAPLRLGLAGGGTDVSPYSDDFGGLVLNATINRYA----YATLAPRQDDRVELVAADsavswQGSMA------ 78
Cdd:PRK13412 606 SDQIVWGRSPVRIDLAGGWTDTPPYCLYSGGNVVNLAIELNGqpplQVYVKPCSEPHIVLRSID-----LGAMEvvrtne 680

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293  79 ---------SSLGLVKGLELHVGVYNRIVRDYHGG--QPLA-----VQITTHSEAPPGSGLGSSSTMVVALLHAFVEYLQ 142
Cdd:PRK13412 681 elrdykkvgSPFSIPKAALCLAGFAPRFSAESYASleEQLKafgsgIEITLLAAIPAGSGLGTSSILAATVLGAISDFCG 760

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293 143 IPLGEYEIAQLAYEIERVdLAFAGGKQDQYAAAFGGFNFME----FDKdRVIVNPLRVKQSVLAELESSLVLFYTGVSRE 218
Cdd:PRK13412 761 LAWDKNEICNRTLVLEQL-LTTGGGWQDQYGGVLPGVKLLQtgagFAQ-SPLVRWLPDSLFTQPEYRDCHLLYYTGITRT 838

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738079293 219 SAKIIEEQTNSMRRGNFASVEAMHRVKQEAVRMKEAILKGDFDSFAESMRLSWEAKKKMASSISNA 284
Cdd:PRK13412 839 AKGILAEIVRSMFLNSTAHLQLLHEMKAHALDMYEAIQRGEFEEFGRLVGKTWEQNKALDSGTNPA 904
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
7-218 6.63e-17

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 80.97  E-value: 6.63e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293   7 GSRRELVrARAPLRLGLAGGGTDvspYSDdfgGLVLNATINRYAYATLAPRQDDRVELVAADSAVSWQGSMAsslGLVKG 86
Cdd:COG0153   14 GEEPEGV-FSAPGRVNLIGEHTD---YNG---GFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVEFDLD---DLEPG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293  87 LELH-----VGVYNRIVRdyHGGQPLAVQITTHSEAPPGSGLGSSSTMVVALLHAFVEYLQIPLGEYEIAQLAYEIERVd 161
Cdd:COG0153   84 EEDGwanyvRGVAWALQE--RGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAENE- 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 738079293 162 laFAG---GKQDQYAAAFGGFNFMefdkDRVIVNPLRVKQsV---LAELesSLVLFYTGVSRE 218
Cdd:COG0153  161 --FVGvpcGIMDQFASALGKKGHA----LLLDCRSLEYEY-VplpLEGY--ALVIVDTNVKHS 214
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 37-269 4.68e-16

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 76.95  E-value: 4.68e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293   37 FGGLVLNATINRYAYATLAPRQDDrvelVAADSAVSWQGsmassLGLVK-GLELHVGVYNRIVRDYHGGQPLAVQITTHS 115
Cdd:TIGR00549  15 YGEPAIAAPIPLRTTVTVIESSDG----SFIESDLGRGS-----LDDAPdELDGLKYVLAEFLSRFSELNPPPLEITIES 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293  116 EAPPGSGLGSSSTMVVALLHAFVEYLQIPLGEYEIAQLAYEIERVdlafAGGKQ---DQYAAAFGGFNFmeFDKDrvivn 192
Cdd:TIGR00549  86 EIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKI----AHGKPsgiDTATSTSGGPVY--FEKG----- 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 738079293  193 plRVKQSVLAELESSLVLFYTGVSRESAKIIEEQTNSMRRGNFASVEAMHRVKQEAVRMKEAILKGDFDSFAESMRL 269
Cdd:TIGR00549 155 --EGEFTKLISLDGYFVIADTGVSGSTKEAVARVRQLLERFPELIDSIMDAIGELTLEAKAALQDGDVESLGELMNI 229
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 111-178 7.65e-13

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 62.57  E-value: 7.65e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 738079293  111 ITTHSEAPPGSGLGSSSTMVVALLHAFVEYLQIPLgeyeiAQLAYEIERVDLAFAGGKQDQYAAAFGG 178
Cdd:pfam00288   2 IEIESNIPLGAGLGSSAALAVALLLALNELFGLPL-----AKLALEAEELAGGGRGGGMDVAASLYGG 64
PRK03817 PRK03817
galactokinase; Provisional
 14-239 1.80e-10

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 61.55  E-value: 1.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293  14 RARAPLRLGLAGGGTDvspYSDdfgGLVLNATINRYAyaTLAPRQDDRVELVAADSAVSWQGSMASSLGLVKGLELHVGV 93
Cdd:PRK03817   2 KVKSPGRVNLIGEHTD---YND---GYVLPFAINLYT--FLEIEKSEKFIFYSENFNEEKTFELDKLEKLNSWADYIKGV 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293  94 YNRIVRdyHGGQPLAVQITTHSEAPPGSGLGSSSTMVVALLHAFVEYLQIPLGEYEIAQLAYEIERVDLAFAGGKQDQYA 173
Cdd:PRK03817  74 IWVLEK--RGYEVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENEFVGVPCGIMDQFA 151

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 738079293 174 AAFGGFNFMEF-DKDRVIVNPLRVKQSVlaelesSLVLFYTGVSRESA--------KIIEEQTNSMRRGNFASVE 239
Cdd:PRK03817 152 VAFGKKDHAIFlDTMTLEYEYVPFPEDY------EILVFDTGVKRELAsseynerrQECEEALKILGKKSSKEVT 220
PRK03926 PRK03926
mevalonate kinase; Provisional
 109-267 1.18e-09

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 58.53  E-value: 1.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293 109 VQITTHSEAPPGSGLGSSSTMVVALLHAFVEYLQIPLGEYEIAQLAYEIErVDLAFAGGKQDQYAAAFGGFnfmefdkdr 188
Cdd:PRK03926  76 VTVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKVE-LLVQGAASPTDTYVSTMGGF--------- 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293 189 vIVNPLRVKqsvLAELESSLVLFYTGVSRESAKIIeeqtnSMRRGNFAS--------VEAMHRVkqeAVRMKEAILKGDF 260
Cdd:PRK03926 146 -VTIPDRKK---LPFPECGIVVGYTGSSGSTKELV-----ANVRKLKEEypeliepiLSSIGKI---SEKGEELILSGDY 213


                 ....*..
gi 738079293 261 DSFAESM 267
Cdd:PRK03926 214 VSLGELM 220
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 98-196 8.30e-09

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 55.88  E-value: 8.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293  98 VRDYHGGQPLAVQITTHSEAPPGSGLGSSSTMVVALLHAFVEYLQIPLGEYEIAQLAYEIER----VdlafaggkqdqyA 173
Cdd:COG0083   68 LLEKLGKEPPGLRIEIEKGIPLGRGLGSSAAAIVAGLVAANALLGLPLSKEELLELATEGEGhpdnV------------A 135

                         90       100
                 ....*....|....*....|....
gi 738079293 174 AA-FGGFNFMEFDKDRVIVNPLRV 196
Cdd:COG0083  136 PAlLGGLVLSRSDGEPVRVVRLPV 159
PduX COG4542
PduX protein involved in propanediol utilization and related proteins [Secondary metabolites ...
 96-161 1.54e-08

PduX protein involved in propanediol utilization and related proteins [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443608 [Multi-domain]  Cd Length: 286  Bit Score: 55.25  E-value: 1.54e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738079293  96 RIVRDYHGGQPLAVQITTHSEAPPGSGLGSSSTMVVALLHAFVEYLQIPLGEYEIAQLAYEIERVD 161
Cdd:COG4542   58 ELTLEHLGLPPLGGRIELRSDIPVGKGMASSTADIAATARAVARALGKELSPEELARLAVAIEPTD 123
PRK01212 PRK01212
homoserine kinase; Provisional
 102-196 5.88e-08

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 53.61  E-value: 5.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293 102 HGGQPLAVQITTHSEAPPGSGLGSSSTMVVALLHAFVEYLQIPLGEYEIAQLAYEIErvdlafagGKQDQYAAA-FGGFN 180
Cdd:PRK01212  75 KLGKPPGLRIELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGE--------GHPDNVAPAlLGGLV 146

                         90
                 ....*....|....*.
gi 738079293 181 FMEfDKDRVIVNPLRV 196
Cdd:PRK01212 147 LAL-EENGVISVKIPV 161
PLN02677 PLN02677
mevalonate kinase
 13-140 1.88e-05

mevalonate kinase


Pssm-ID: 215363 [Multi-domain]  Cd Length: 387  Bit Score: 45.98  E-value: 1.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293  13 VRARAPLRLGLAGGGTDVSpysddfGGLVLNATINRYAYATLAPR----QDDRVELVAADSAV--SW------------- 73
Cdd:PLN02677   3 VKARAPGKIILAGEHAVVH------GSTAVAAAIDLYTYVSLRFPpsaeNDDTLKLQLKDLGLefSWplarikealpdlg 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293  74 ------------------------QGSMASSLGLVKGLELHVGVYNRIVrdyhGGQPLAVQITthSEAPPGSGLGSSSTM 129
Cdd:PLN02677  77 tpcpstptscseetlksiaalveeQNIPEAKIWLSSGVSAFLWLYTSIL----GFNPATVVVT--SELPLGSGLGSSAAF 150

                        170
                 ....*....|.
gi 738079293 130 VVALLHAFVEY 140
Cdd:PLN02677 151 CVALSAALLAA 161
PRK05101 PRK05101
galactokinase; Provisional
 16-177 1.90e-05

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 46.07  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293  16 RAPLRLGLAGGGTDvspYSDdfgGLVLNATINRYAYATLAPRQDDRVELVAADsavswQGSMASSLGLVKGLELHV---- 91
Cdd:PRK05101  24 QAPGRVNLIGEHTD---YND---GFVLPCAIDYQTVISCAKRDDRIVRVIAAD-----YDNQQDEFSLDAPIVPHPeqqw 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293  92 -----GVYNRIVRDYH--GGQPLAVQitthSEAPPGSGLGSSSTMVVALLHAFVEYLQIPLGEYEIAQLAYEIERvdlAF 164
Cdd:PRK05101  93 anyvrGVVKHLQERNPdfGGADLVIS----GNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEIALNGQEAEN---QF 165

                        170
                 ....*....|....*.
gi 738079293 165 AG---GKQDQYAAAFG 177
Cdd:PRK05101 166 VGcncGIMDQLISALG 181
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 119-267 3.54e-03

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 38.68  E-value: 3.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293 119 PGSGLGSSSTMVVALLHAFVEYLQIPLGEYEIAQLAYEIErvdlafaGGKQ------DQYAAAFGGFNFMEFDKDRVIVN 192
Cdd:PTZ00298 105 PSSGIGASASDVVSLSRALSELYQLNLTEEEVNLSAFVGE-------GGYHgtpsgaDNTAATYGGLISYRRVNGKSVFK 177

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738079293 193 PLRVKQSVlaelesSLVLFYTGVSRESAKIIEEqTNSMRRGNFASVEAMHRVKQEAVR-MKEAILKGDFDSFAESM 267
Cdd:PTZ00298 178 RIAFQQPL------YLVVCSTGITASTTKVVGD-VRKLKENQPTWFNRLLENYNACVSeAKEALQKGNLFRVGELM 246
PLN02521 PLN02521
galactokinase
 104-159 8.05e-03

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 38.15  E-value: 8.05e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 738079293 104 GQPLAVQITTHSEAPPGSGLGSSSTMV----VALLHAFveylQIPLGEYEIAQLAYEIER 159
Cdd:PLN02521 145 GPPVGLDVVVDGTVPTGSGLSSSAALVcsaaIAIMAAL----GLNFTKKEVAQFTCKCER 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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