|
Name |
Accession |
Description |
Interval |
E-value |
| GT4_PimA-like |
cd03801 |
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ... |
23-404 |
1.19e-37 |
|
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.
Pssm-ID: 340831 [Multi-domain] Cd Length: 366 Bit Score: 139.98 E-value: 1.19e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 23 KLGVVIELASFDKGGLEKVVLDSAIAFDRSRFDVTIVTPGKVGHLGTvARDAGLRVVGLPAGNPLSAYERVLAE------ 96
Cdd:cd03801 1 KILLLSPELPPPVGGAERHVRELARALAARGHDVTVLTPADPGEPPE-ELEDGVIVPLLPSLAALLRARRLLRElrpllr 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 97 -DGIDIAMSHFSDTGYPLFEKFRIPNVTYIHNVYAFFSEAQARAFADNDRYVERY----------VSVSRNATRFAVHNL 165
Cdd:cd03801 80 lRKFDVVHAHGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLLLAAERRLLARAeallrradavIAVSEALRDELRALG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 166 GVPEAKVETIPNGLILSEheareklTQTLTRAELGLADTDYVFANVASYNLHKGHYLMADAMRHLLARRRDVKILCVGnv 245
Cdd:cd03801 160 GIPPEKIVVIPNGVDLER-------FSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGPDVRLVIVG-- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 246 VYPPHVDALRAYldEQGLSGHILMPGYV--ADVAAVHRIADAFLLPSFIEGWSIAMNEAMFYRKPMVLSDTGASAEVIEQ 323
Cdd:cd03801 231 GDGPLRAELEEL--ELGLGDRVRFLGFVpdEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVED 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 324 DDIGILVPNEYGDTielnskrldelayaphqyrtapiLADALERMASNRDEWRERGARGRDKIYAHYDFTEIVARYEALI 403
Cdd:cd03801 309 GEGGLVVPPDDVEA-----------------------LADALLRLLADPELRARLGRAARERVAERFSWERVAERLLDLY 365
|
.
gi 738089395 404 E 404
Cdd:cd03801 366 R 366
|
|
| GT4_WbnK-like |
cd03807 |
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ... |
32-402 |
8.11e-35 |
|
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.
Pssm-ID: 340836 [Multi-domain] Cd Length: 362 Bit Score: 132.06 E-value: 8.11e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 32 SFDKGGLEKVVLDSAIAFDRSRFDVTIVTPGKVGHLGTVARDAGLRVVGLPAGNPLSA-----YERVLAEDGIDIAMSHF 106
Cdd:cd03807 8 GLNVGGAETMLLRLLEHMDKSRFEHVVISLTGDGVLGEELLAAGVPVVCLGLSSGKDPgvllrLAKLIRKRNPDVVHTWM 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 107 SDTGY--PLFEKFR--IPNVTYIHNVYAFFSE-----AQARAFADNDRYVeryVSVSRNATRFaVHNLGVPEAKVETIPN 177
Cdd:cd03807 88 YHADLigGLAAKLAggVKVIWSVRSSNIPQRLtrlvrKLCLLLSKFSPAT---VANSSAVAEF-HQEQGYAKNKIVVIYN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 178 GLILSEHEAREKLTqTLTRAELGLADTDYVFANVASYNLHKGHYLMADAMRHLLARRRDVKILCVGNvvyPPHVDALRAY 257
Cdd:cd03807 164 GIDLFKLSPDDASR-ARARRRLGLAEDRRVIGIVGRLHPVKDHSDLLRAAALLVETHPDLRLLLVGR---GPERPNLERL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 258 LDEQGLSGHILMPGYVADVAAVHRIADAFLLPSFIEGWSIAMNEAMFYRKPMVLSDTGASAEVIEqDDIGILVPNEYGDT 337
Cdd:cd03807 240 LLELGLEDRVHLLGERSDVPALLPAMDIFVLSSRTEGFPNALLEAMACGLPVVATDVGGAAELVD-DGTGFLVPAGDPQA 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 738089395 338 ielnskrldelayaphqyrtapiLADALERMASNRDEWRERGARGRDKIYAHYDFTEIVARYEAL 402
Cdd:cd03807 319 -----------------------LADAIRALLEDPEKRARLGRAARERIANEFSIDAMVRRYETL 360
|
|
| GT4_GT28_WabH-like |
cd03811 |
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ... |
32-358 |
8.28e-28 |
|
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.
Pssm-ID: 340839 [Multi-domain] Cd Length: 351 Bit Score: 112.45 E-value: 8.28e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 32 SFDKGGLEKVVLDSAIAFDRSRFDVTIVT-----------PGKVGHLGTVARDAGLRVVGLPAGnpLSAYERVLAEDGID 100
Cdd:cd03811 8 SLSGGGAERVLLNLANALDKRGYDVTLVLlrdegdldkqlNGDVKLIRLLIRVLKLIKLGLLKA--ILKLKRILKRAKPD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 101 IAMSHFSDTGY--PLFEKFRIPNVTYIHNVY--AFFSEAQARAFADNDRYVERYVSVSRNATRFAVHNLGVPEAKVETIP 176
Cdd:cd03811 86 VVISFLGFATYivAKLAAARSKVIAWIHSSLskLYYLKKKLLLKLKLYKKADKIVCVSKGIKEDLIRLGPSPPEKIEVIY 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 177 NGLILSEHEAREKLTQTLTRaelglaDTDYVFANVASYNLHKGHYLMADAMRHLLARRRDVKILCVGNVvyPPHvDALRA 256
Cdd:cd03811 166 NPIDIDRIRALAKEPILNEP------EDGPVILAVGRLDPQKGHDLLIEAFAKLRKKYPDVKLVILGDG--PLR-EELEK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 257 YLDEQGLSGHILMPGYVADVAAVHRIADAFLLPSFIEGWSIAMNEAMFYRKPMVLSDTGASAEVIEQDDIGILVPNEYGD 336
Cdd:cd03811 237 LAKELGLAERVIFLGFQSNPYPYLKKADLFVLSSRYEGFPNVLLEAMALGTPVVSTDCPGPREILDDGENGLLVPDGDAA 316
|
330 340 350
....*....|....*....|....*....|..
gi 738089395 337 ----------TIELNSKRLDELAYAPHQYRTA 358
Cdd:cd03811 317 alagilaallQKKLDAALRERLAKAQEAVFRE 348
|
|
| GT4_WavL-like |
cd03819 |
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ... |
33-377 |
1.03e-24 |
|
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.
Pssm-ID: 340846 [Multi-domain] Cd Length: 345 Bit Score: 103.97 E-value: 1.03e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 33 FDKGGLEKVVLDSAIAFDRSRFDVTIVTPGKVGHLGTVARDAGLRVVGLP---AGNPLSAYERVLAEDGIDIAMSHfSDT 109
Cdd:cd03819 8 LEIGGAETYILDLARALAERGHRVLVVTAGGPLLPRLRQIGIGLPGLKVPllrALLGNVRLARLIRRERIDLIHAH-SRA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 110 ----GYPLFEKFRIPNVTYIHNVYAFFSEAQARAFADNdRYVERYVSVSRNATRFAVHNLGVPEAKVETIPNGLILSEHE 185
Cdd:cd03819 87 pawlGWLASRLTGVPLVTTVHGSYLATYHPKDFALAVR-ARGDRVIAVSELVRDHLIEALGVDPERIRVIPNGVDTDRFP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 186 AREKltqTLTRAELGLADTDYVFANVASYNLHKGHYLMADAMRhLLARRRDVKILCVGNvvyPPHVDALRAYLDEQGLSG 265
Cdd:cd03819 166 PEAE---AEERAQLGLPEGKPVVGYVGRLSPEKGWLLLVDAAA-ELKDEPDFRLLVAGD---GPERDEIRRLVERLGLRD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 266 HILMPGYVADVAAVHRIADAFLLPSFIEGWSIAMNEAMFYRKPMVLSDTGASAEVIEQDDIGILVPNeyGDTielnskrl 345
Cdd:cd03819 239 RVTFTGFREDVPAALAASDVVVLPSLHEEFGRVALEAMACGTPVVATDVGGAREIVVHGRTGLLVPP--GDA-------- 308
|
330 340 350
....*....|....*....|....*....|..
gi 738089395 346 DELAYAPHQYRTAPILADALERMASNRDEWRE 377
Cdd:cd03819 309 EALADAIRAAKLLPEAREKLQAAAALTEAVRE 340
|
|
| GT4_CapM-like |
cd03808 |
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ... |
36-400 |
2.64e-23 |
|
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.
Pssm-ID: 340837 [Multi-domain] Cd Length: 358 Bit Score: 99.98 E-value: 2.64e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 36 GGLEKVVLDSAIAFDRSRFDVTIVTPGkVGHLGTVARDAGLRVVGLP---AG-NPLS------AYERVLAEDGIDIAMSH 105
Cdd:cd03808 10 GGFQSFRLPLIKALVKKGYEVHVIAPD-GDKLSDELKELGVKVIDIPilrRGiNPLKdlkalfKLYKLLKKEKPDIVHCH 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 106 FSDTG-YPLFEKFRIPNVTYIHNV--YAFFSEAQAR-----------AFADNDRYVeryvSVSRNATRFAVHNLGVPEAK 171
Cdd:cd03808 89 TPKPGiLGRLAARLAGVPKVIYTVhgLGFVFTEGKLlrllyllleklALLFTDKVI----FVNEDDRDLAIKKGIIKKKK 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 172 VETIP-NGLILSEHEAREKltqtltraelGLADTDYVFANVASYNLHKGHYLMADAMRHLLARRRDVKILCVGNvvyPPH 250
Cdd:cd03808 165 TVLIPgSGVDLDRFQYSPE----------SLPSEKVVFLFVARLLKDKGIDELIEAAKILKKKGPNVRFLLVGD---GEL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 251 VDALRAYLDEQGLSGHILMPGYVADVAAVHRIADAFLLPSFIEGWSIAMNEAMFYRKPMVLSDTGASAEVIEQDDIGILV 330
Cdd:cd03808 232 ENPSEILIEKLGLEGRIEFLGFRSDVPELLAESDVFVLPSYREGLPRSLLEAMAAGRPVITTDVPGCRELVIDGVNGFLV 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 331 PNeyGDTIElnskrldelayaphqyrtapiLADALERMASNRDEWRERGARGRDKIYAHYDFTEIVARYE 400
Cdd:cd03808 312 PP--GDVEA---------------------LADAIEKLIEDPELRKEMGEAARKRVEEKFDEEKVVNKLL 358
|
|
| GT4_WlbH-like |
cd03798 |
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ... |
23-406 |
1.09e-22 |
|
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.
Pssm-ID: 340828 [Multi-domain] Cd Length: 376 Bit Score: 98.61 E-value: 1.09e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 23 KLGVVIELASFDKGGLEKVVLDsaiafDRSRFDVTIVTPGKVGHLGTVARDAGLRVVGlPAGNPLSAYERVLAEDGIDia 102
Cdd:cd03798 29 RRGVDVEVLAPAPWGPAAARLL-----RKLLGEAVPPRDGRRLLPLKPRLRLLAPLRA-PSLAKLLKRRRRGPPDLIH-- 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 103 mSHFSDTGYPLFEKFR----IPNVTYIH----NVYAFfSEAQARAFADNDRYVERYVSVSRNATRFAVhNLGVPEAKVET 174
Cdd:cd03798 101 -AHFAYPAGFAAALLArlygVPYVVTEHgsdiNVFPP-RSLLRKLLRWALRRAARVIAVSKALAEELV-ALGVPRDRVDV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 175 IPNGLILSEHEAREkltqtltrAELGLADTDYVFANVASYNLHKGHYLMADAMRHLLARRRDVKILCVGNvvyPPHVDAL 254
Cdd:cd03798 178 IPNGVDPARFQPED--------RGLGLPLDAFVILFVGRLIPRKGIDLLLEAFARLAKARPDVVLLIVGD---GPLREAL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 255 RAYLDEQGLSGHILMPGYV--ADVAAVHRIADAFLLPSFIEGWSIAMNEAMFYRKPMVLSDTGASAEVIEQDDIGILVPn 332
Cdd:cd03798 247 RALAEDLGLGDRVTFTGRLphEQVPAYYRACDVFVLPSRHEGFGLVLLEAMACGLPVVATDVGGIPEVVGDPETGLLVP- 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 738089395 333 eygdtielnSKRLDELAYAphqyrtapiLADALermasNRDEWRERGARGRDKIYAHYDFTEIVARYEALIEDV 406
Cdd:cd03798 326 ---------PGDADALAAA---------LRRAL-----AEPYLRELGEAARARVAERFSWVKAADRIAAAYRDV 376
|
|
| GT4_MtfB-like |
cd03809 |
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ... |
106-384 |
1.27e-22 |
|
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.
Pssm-ID: 340838 [Multi-domain] Cd Length: 362 Bit Score: 98.20 E-value: 1.27e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 106 FSDTGYPLFEKFRIPNVTYIHNVyAFFSEAQARAFADNDRY----------VERYVSVSRNATRFAVHNLGVPEAKVETI 175
Cdd:cd03809 89 HSPHNTAPLLLKGCPQVVTIHDL-IPLRYPEFFPKRFRLYYrlllpislrrADAIITVSEATRDDIIKFYGVPPEKIVVI 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 176 PNGlilSEHEAREKLTQTLTRAELGLADtDYVFAnVASYNLHKGHYLMADAMRHLLARRRDVKILCVGNvvYPPHVDALR 255
Cdd:cd03809 168 PLG---VDPSFFPPESAAVLIAKYLLPE-PYFLY-VGTLEPRKNHERLLKAFALLKKQGGDLKLVIVGG--KGWEDEELL 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 256 AYLDEQGLSGHILMPGYVAD--VAAVHRIADAFLLPSFIEGWSIAMNEAMFYRKPMVLSDTGASAEVIEqdDIGILV-PN 332
Cdd:cd03809 241 DLVKKLGLGGRVRFLGYVSDedLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASNISVLPEVAG--DAALYFdPL 318
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 738089395 333 EYGDtielnskrldelayaphqyrtapiLADALERMASNRDEWRERGARGRD 384
Cdd:cd03809 319 DPES------------------------IADAILRLLEDPSLREELIRKGLE 346
|
|
| Glyco_trans_1_4 |
pfam13692 |
Glycosyl transferases group 1; |
218-340 |
3.03e-20 |
|
Glycosyl transferases group 1;
Pssm-ID: 463957 [Multi-domain] Cd Length: 138 Bit Score: 86.03 E-value: 3.03e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 218 KGHYLMADAMRHLLARRRDVKILCVGNVVYpphvDALRAYLDeqGLSGHILMPGYVADVAAVHRIADAFLLPSFIEGWSI 297
Cdd:pfam13692 15 KGVDYLLEAVPLLRKRDNDVRLVIVGDGPE----EELEELAA--GLEDRVIFTGFVEDLAELLAAADVFVLPSLYEGFGL 88
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 738089395 298 AMNEAMFYRKPMVLSDTGASAEVIEQDDiGILVPNeyGDTIEL 340
Cdd:pfam13692 89 KLLEAMAAGLPVVATDVGGIPELVDGEN-GLLVPP--GDPEAL 128
|
|
| RfaB |
COG0438 |
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ... |
276-408 |
9.30e-20 |
|
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440207 [Multi-domain] Cd Length: 123 Bit Score: 84.27 E-value: 9.30e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 276 VAAVHRIADAFLLPSFIEGWSIAMNEAMFYRKPMVLSDTGASAEVIEQDDIGILVPNEygdtielnskrldelayaphqy 355
Cdd:COG0438 14 LEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPG---------------------- 71
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 738089395 356 rTAPILADALERMASNRDEWRERGARGRDKIYAHYDFTEIVARYEALIEDVVR 408
Cdd:COG0438 72 -DPEALAEAILRLLEDPELRRRLGEAARERAEERFSWEAIAERLLALYEELLA 123
|
|
| Glycos_transf_1 |
pfam00534 |
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ... |
204-332 |
2.37e-18 |
|
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.
Pssm-ID: 425737 [Multi-domain] Cd Length: 158 Bit Score: 81.55 E-value: 2.37e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 204 TDYVFANVASYNLHKGHYLMADAMRHLLARRRDVKILCVGNvvyPPHVDALRAYLDEQGLSGHILMPGYV--ADVAAVHR 281
Cdd:pfam00534 1 KKKIILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLVIAGD---GEEEKRLKKLAEKLGLGDNVIFLGFVsdEDLPELLK 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 738089395 282 IADAFLLPSFIEGWSIAMNEAMFYRKPMVLSDTGASAEVIEQDDIGILVPN 332
Cdd:pfam00534 78 IADVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKP 128
|
|
| stp2 |
TIGR03088 |
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ... |
146-407 |
2.99e-18 |
|
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.
Pssm-ID: 132132 [Multi-domain] Cd Length: 374 Bit Score: 85.55 E-value: 2.99e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 146 YVERYVSVSRNATRFAVHNLGVPEAKVETIPNGLilsehEAREKLTQTLTRAEL----GLADTDYVFANVASYNLHKGHY 221
Cdd:TIGR03088 136 LIHHYVAVSRDLEDWLRGPVKVPPAKIHQIYNGV-----DTERFHPSRGDRSPIlppdFFADESVVVGTVGRLQAVKDQP 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 222 LMADAMRHLLARRRD----VKILCVGNvvyPPHVDALRAYLDEQGLSGHILMPGYVADVAAVHRIADAFLLPSFIEGWSI 297
Cdd:TIGR03088 211 TLVRAFALLVRQLPEgaerLRLVIVGD---GPARGACEQMVRAAGLAHLVWLPGERDDVPALMQALDLFVLPSLAEGISN 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 298 AMNEAMFYRKPMVLSDTGASAEVIEQDDIGILVPNeyGDtielnskrldelayaphqyrtAPILADALERMASNRDEWRE 377
Cdd:TIGR03088 288 TILEAMASGLPVIATAVGGNPELVQHGVTGALVPP--GD---------------------AVALARALQPYVSDPAARRA 344
|
250 260 270
....*....|....*....|....*....|
gi 738089395 378 RGARGRDKIYAHYDFTEIVARYEALIEDVV 407
Cdd:TIGR03088 345 HGAAGRARAEQQFSINAMVAAYAGLYDQLL 374
|
|
| GT4_CapH-like |
cd03812 |
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ... |
32-321 |
7.91e-16 |
|
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).
Pssm-ID: 340840 [Multi-domain] Cd Length: 357 Bit Score: 78.10 E-value: 7.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 32 SFDKGGLEKVVLDSAIAFDRSRFDVTIV-TPGKVGHLGTVARDAGLRVVGLPAG--NPLSAYERVL---AEDGIDIAMSH 105
Cdd:cd03812 8 GMNVGGIETFLMNLYRKLDKSKIEFDFLaTSDDKGEYDEELEELGGKIFYIPPKkkNIIKYFIKLLkliKKEKYDIVHVH 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 106 ---FSDTGYPLFEKFRIP-----------NVTYIHNVYAFFSEAQARAFADNdryverYVSVSRNATR--FAVHNLGvpe 169
Cdd:cd03812 88 gssSNGIILLLAAKAGVPvriahshntkdSSIKLRKIRKNVLKKLIERLSTK------YLACSEDAGEwlFGEVENG--- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 170 aKVETIPNG-----LILSEhEAREKltqtltRAELGLADTDYVFANVASYNLHKGHYLMADAMRHLLARRRDVKILCVGN 244
Cdd:cd03812 159 -KFKVIPNGidiekYKFNK-EKRRK------RRKLLILEDKLVLGHVGRFNEQKNHSFLIDIFEELKKKNPNVKLVLVGE 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 738089395 245 VvypPHVDALRAYLDEQGLSGHILMPGYVADVAAVHRIADAFLLPSFIEGWSIAMNEAMFYRKPMVLSDTGASAEVI 321
Cdd:cd03812 231 G---ELKEKIKEKVKELGLEDKVIFLGFRNDVSEILSAMDVFLFPSLYEGLPLVAVEAQASGLPCLLSDTITKECDI 304
|
|
| GT4_WbdM_like |
cd04951 |
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ... |
153-331 |
6.14e-15 |
|
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.
Pssm-ID: 340857 [Multi-domain] Cd Length: 360 Bit Score: 75.56 E-value: 6.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 153 VSRNATRFAVHNLGVPEAKVETIPNGLILSEHEaREKLTQTLTRAELGLADTDYVFANVASYNLHKGHYLMADAMRHLLA 232
Cdd:cd04951 137 VSREALDEFIAKKAFSKNKSVPVYNGIDLNKFK-KDINVRLKIRNKLNLKNDEFVILNVGRLTEAKDYPNLLLAISELIL 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 233 RRRDVKILCVGNvvyPPHVDALRAYLDEQGLSGHILMPGYVADVAAVHRIADAFLLPSFIEGWSIAMNEAMFYRKPMVLS 312
Cdd:cd04951 216 SKNDFKLLIAGD---GPLRNELERLICNLNLVDRVILLGQISNISEYYNAADLFVLSSEWEGFGLVVAEAMACERPVVAT 292
|
170
....*....|....*....
gi 738089395 313 DTGASAEVIeqDDIGILVP 331
Cdd:cd04951 293 DAGGVAEVV--GDHNYVVP 309
|
|
| GT4_WcaC-like |
cd03825 |
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ... |
171-406 |
2.18e-14 |
|
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.
Pssm-ID: 340851 [Multi-domain] Cd Length: 364 Bit Score: 73.91 E-value: 2.18e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 171 KVETIPNGL---ILSEHEAREkltqtlTRAELGLADTDYV--FANVASYNLHKGHYLMADAMRhLLARRRDVKILCVGNv 245
Cdd:cd03825 162 PVVVIPNGIdteIFAPVDKAK------ARKRLGIPQDKKVilFGAESVTKPRKGFDELIEALK-LLATKDDLLLVVFGK- 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 246 vypphvdalrayLDEQ--GLSGHILMPGYVADVAAVHRI---ADAFLLPSFIEGWSIAMNEAMFYRKPMVLSDTGASAEV 320
Cdd:cd03825 234 ------------NDPQivILPFDIISLGYIDDDEQLVDIysaADLFVHPSLADNLPNTLLEAMACGTPVVAFDTGGSPEI 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 321 IEQDDIGILVPNeyGDTIElnskrldelayaphqyrtapiLADALERMASNRDEWRERGARGRDKIYAHYDFTEIVARYE 400
Cdd:cd03825 302 VQHGVTGYLVPP--GDVQA---------------------LAEAIEWLLANPKERESLGERARALAENHFDQRVQAQRYL 358
|
....*.
gi 738089395 401 ALIEDV 406
Cdd:cd03825 359 ELYKDL 364
|
|
| GT4_AmsD-like |
cd03820 |
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ... |
36-401 |
8.32e-13 |
|
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.
Pssm-ID: 340847 [Multi-domain] Cd Length: 351 Bit Score: 69.19 E-value: 8.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 36 GGLEKVVLDSAIAFDRSRFDVTIVTPGKVGHLGTVARDAGLRVVGLPAG---------NPLSAYER---VLAEDGIDIAM 103
Cdd:cd03820 13 GGAERVAINLANHLAKKGYDVTIISLDSAEKPPFYELDDNIKIKNLGDRkyshfklllKYFKKVRRlrkYLKNNKPDVVI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 104 S-HFSDTGYPLFEKFRIPNVTYIHNVYAFFSEAQARAFAD--NDRYVERYVSVSRNAtrfAVHNLGVPEAKVETIPNGLI 180
Cdd:cd03820 93 SfRTSLLTFLALIGLKSKLIVWEHNNYEAYNKGLRRLLLRrlLYKRADKIVVLTEAD---KLKKYKQPNSNVVVIPNPLS 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 181 LSEHEAREKLTQTltraelgladtdyVFANVASYNLHKGHYLMADAMRHLLARRRDVKILCVGNvvyPPHVDALRAYLDE 260
Cdd:cd03820 170 FPSEEPSTNLKSK-------------RILAVGRLTYQKGFDLLIEAWALIAKKHPDWKLRIYGD---GPEREELEKLIDK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 261 QGLSGHILMPGYVADVAAVHRIADAFLLPSFIEGWSIAMNEAMFYRKPMVLSD--TGASaEVIEQDDIGILVPNeyGDti 338
Cdd:cd03820 234 LGLEDRVKLLGPTKNIAEEYANSSIFVLSSRYEGFPMVLLEAMAYGLPIISFDcpTGPS-EIIEDGENGLLVPN--GD-- 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 738089395 339 elnskrldelayaphqyrtAPILADALERMASNRDEWRERGARGRDKIyAHYDFTEIVARYEA 401
Cdd:cd03820 309 -------------------VDALAEALLRLMEDEELRKKMGKNARKNA-ERFSIEKIIKQWEE 351
|
|
| Glycosyltransferase_GTB-type |
cd01635 |
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ... |
211-330 |
9.00e-13 |
|
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
Pssm-ID: 340816 [Multi-domain] Cd Length: 235 Bit Score: 67.43 E-value: 9.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 211 VASYNLHKGHYLMADAMRHLLARRRDVKILCVGNVVYPPHVDALRAYLDEQGLSGHILMPGYVADVAAVHRIADAFLLPS 290
Cdd:cd01635 116 VGRLVPEKGIDLLLEALALLKARLPDLVLVLVGGGGEREEEEALAAALGLLERVVIIGGLVDDEVLELLLAAADVFVLPS 195
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 738089395 291 FIEGWSIAMNEAMFYRKPMVLSDTGASAEVIEQDDIGILV 330
Cdd:cd01635 196 RSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGLLV 235
|
|
| GT4_Bme6-like |
cd03821 |
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ... |
27-333 |
9.32e-12 |
|
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.
Pssm-ID: 340848 [Multi-domain] Cd Length: 377 Bit Score: 65.85 E-value: 9.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 27 VIELASFDKGGLEKVVLDSAIAFDRSRFDVTIVTPGkvghlgtvarDAGLRVVGLPAGNPLSayeRVLAEDGIDIAMSHF 106
Cdd:cd03821 5 VTPSISPKAGGPVKVVLRLAAALAALGHEVTIVSTG----------DGYESLVVEENGRYIP---PQDGFASIPLLRQGA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 107 SDTGYPLF------EKFRIPNVTYIHNVYAFFSEAQARAFADNDR-YV---------------------ERYVSVSRNAT 158
Cdd:cd03821 72 GRTDFSPGlpnwlrRNLREYDVVHIHGVWTYTSLAACKLARRRGIpYVvsphgmldpwalqqkhwkkriALHLIERRNLN 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 159 RFA-VHNLG----------VPEAKVETIPNGLILSEHEAREKLtqtltRAELGLADTDYVFANVASYNLHKGHYLMADAM 227
Cdd:cd03821 152 NAAlVHFTSeqeadelrrfGLEPPIAVIPNGVDIPEFDPGLRD-----RRKHNGLEDRRIILFLGRIHPKKGLDLLIRAA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 228 RHLLARRRDVKILCVGnvvYPPH-VDALRAYLDEQGLSGHILMPGYVADVA--AVHRIADAFLLPSFIEGWSIAMNEAMF 304
Cdd:cd03821 227 RKLAEQGRDWHLVIAG---PDDGaYPAFLQLQSSLGLGDRVTFTGPLYGEAkwALYASADLFVLPSYSENFGNVVAEALA 303
|
330 340
....*....|....*....|....*....
gi 738089395 305 YRKPMVLSDTGASAEVIEQDDIGILVPNE 333
Cdd:cd03821 304 CGLPVVITDKCGLSELVEAGCGVVVDPNV 332
|
|
| GT4_mannosyltransferase-like |
cd03822 |
mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most ... |
112-399 |
1.19e-11 |
|
mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.
Pssm-ID: 340849 [Multi-domain] Cd Length: 370 Bit Score: 65.48 E-value: 1.19e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 112 PLFEKFRIPNVTYIHNVYAFFS--EAQARAFADNDRYVERYVSVSRNATRFAVHNLGVPEAKVETIPNGLIL--SEHEAR 187
Cdd:cd03822 98 GLLLHLRIPVITTLHTVLDLSDpgKQALKVLFRIATLSERVVVMAPISRFLLVRIKLIPAVNIEVIPHGVPEvpQDPTTA 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 188 EKltqtltrAELGLADTdYVFANVASYNLHKGHYLMADAMRHLLARRRDVKILCVG----NVVYPPHVDALRAYLDEQGL 263
Cdd:cd03822 178 LK-------RLLLPEGK-KVILTFGFIGPGKGLEILLEALPELKAEFPDVRLVIAGelhpSLARYEGERYRKAAIEELGL 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 264 SGHILMPGYVADVAAVHRI---ADAFLLP--SFIEGWSIAMNEAMFYRKPMVLSDTGaSAEVIEQDDIGILVPneygdti 338
Cdd:cd03822 250 QDHVDFHNNFLPEEEVPRYisaADVVVLPylNTEQSSSGTLSYAIACGKPVISTPLR-HAEELLADGRGVLVP------- 321
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 738089395 339 elnskrldelayaphqYRTAPILADALERMASN---RDEWRERGARgrdkiYAHYDFTEIVARY 399
Cdd:cd03822 322 ----------------FDDPSAIAEAILRLLEDderRQAIAERAYA-----YARAMTWESIADR 364
|
|
| GT4_sucrose_synthase |
cd03800 |
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ... |
34-401 |
1.19e-11 |
|
sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.
Pssm-ID: 340830 [Multi-domain] Cd Length: 398 Bit Score: 65.72 E-value: 1.19e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 34 DKGGLEKVVLDSAIAFDRSRFDVTIVTPGKVGHLGTVARDA-GLRVVGLPAGNP-------LSAY--------ERVLAED 97
Cdd:cd03800 19 DTGGQNVYVLELARALAELGYQVDIFTRRISPADPEVVEIApGARVIRVPAGPPeylpkeeLWPYleefadglLRFIARE 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 98 GI--DIAMSHFSDTGYP---LFEKFRIPNVTYIHN---VYAFFSEAQARAFADNDRYVE--------RYVSVSRNATRFA 161
Cdd:cd03800 99 GGryDLIHSHYWDSGLVgalLARRLGVPLVHTFHSlgrVKYRHLGAQDTYHPSLRITAEeqileaadRVIASTPQEADEL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 162 VHNLGVPEAKVETIPNGL------ILSEHEARekltqtltRAELGL-ADTDYVFAnVASYNLHKGHYLMADAMRHLLARR 234
Cdd:cd03800 179 ISLYGADPSRINVVPPGVdlerffPVDRAEAR--------RARLLLpPDKPVVLA-LGRLDPRKGIDTLVRAFAQLPELR 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 235 RDVKILCVGNVVYPPHVD---ALRAYLDEQGLSGHILMPGYV--ADVAAVHRIADAFLLPSFIEGWSIAMNEAMFYRKPM 309
Cdd:cd03800 250 ELANLVLVGGPSDDPLSMdreELAELAEELGLIDRVRFPGRVsrDDLPELYRAADVFVVPSLYEPFGLTAIEAMACGTPV 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 310 VLSDTGASAEVIEQDDIGILVPneygdtielnskrldelAYAPHQyrtapiLADALERMASNRDEWRERGARGRDKIYAH 389
Cdd:cd03800 330 VATAVGGLQDIVRDGRTGLLVD-----------------PHDPEA------LAAALRRLLDDPALWQRLSRAGLERARAH 386
|
410
....*....|..
gi 738089395 390 YDFTEIVARYEA 401
Cdd:cd03800 387 YTWESVADQLLT 398
|
|
| GT4_BshA-like |
cd04962 |
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ... |
118-406 |
1.42e-09 |
|
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.
Pssm-ID: 340859 [Multi-domain] Cd Length: 370 Bit Score: 59.29 E-value: 1.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 118 RIPNVTYIHN-----VYAFFSEAQARAFADNDRyvERYVSVSrNATRFAVHNLGVPEAKVETIPNglILSEHEAREKLTQ 192
Cdd:cd04962 110 KIPIVTTLHGtditlVGYDPSLQPAVRFSINKS--DRVTAVS-SSLRQETYELFDVDKDIEVIHN--FIDEDVFKRKPAG 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 193 TLTRAELGLADtDYVFANVASYNLHKGhylMADAMR--HLLARRRDVKILCVGNvvyPPHVDALRAYLDEQGLSGHILMP 270
Cdd:cd04962 185 ALKRRLLAPPD-EKVVIHVSNFRPVKR---IDDVVRvfARVRRKIPAKLLLVGD---GPERVPAEELARELGVEDRVLFL 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 271 GYVADVAAVHRIADAFLLPSFIEGWSIAMNEAMFYRKPMVLSDTGASAEVIEQDDIGILVPneYGDtIELNSKrldelay 350
Cdd:cd04962 258 GKQDDVEELLSIADLFLLPSEKESFGLAALEAMACGVPVVSSNAGGIPEVVKHGETGFLSD--VGD-VDAMAK------- 327
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 738089395 351 aphqyRTAPILADalermasnRDEWRERGARGRDKIYAHYDFTEIVARYEALIEDV 406
Cdd:cd04962 328 -----SALSILED--------DELYNRMGRAARKRAAERFDPERIVPQYEAYYRRL 370
|
|
| GT4_WbuB-like |
cd03794 |
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ... |
118-399 |
1.77e-08 |
|
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.
Pssm-ID: 340825 [Multi-domain] Cd Length: 391 Bit Score: 55.81 E-value: 1.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 118 RIPNVTYIHNVYAFFSEAQARAFADND-------RYVERY--------VSVSRNATRFAVhNLGVPEAKVETIPNGlilS 182
Cdd:cd03794 120 KLRGAPFILDVRDLWPESLIALGVLKKgsllkllKKLERKlyrladaiIVLSPGLKEYLL-RKGVPKEKIIVIPNW---A 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 183 EHEAREKLTQTLTRAELGLADT-DYVFA-NVASYNlhkGHYLMADAMRhLLARRRDVKILCVGNVvypPHVDALRAYLDE 260
Cdd:cd03794 196 DLEEFKPPPKDELRKKLGLDDKfVVVYAgNIGKAQ---GLETLLEAAE-RLKRRPDIRFLFVGDG---DEKERLKELAKA 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 261 QGLSGHILMPgYV--ADVAAVHRIADAFLLP---SFIEGWSIA--MNEAMFYRKPMVLSDTGASAEVIEQDDIGILVPNE 333
Cdd:cd03794 269 RGLDNVTFLG-RVpkEEVPELLSAADVGLVPlkdNPANRGSSPskLFEYMAAGKPILASDDGGSDLAVEINGCGLVVEPG 347
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738089395 334 ygdtielnskRLDELAyaphqyrtapilaDALERMASNRDEWRERGARGRDKIYAHYDfTEIVARY 399
Cdd:cd03794 348 ----------DPEALA-------------DAILELLDDPELRRAMGENGRELAEEKFS-REKLADR 389
|
|
| Glyco_transf_4 |
pfam13439 |
Glycosyltransferase Family 4; |
36-178 |
2.60e-08 |
|
Glycosyltransferase Family 4;
Pssm-ID: 463877 [Multi-domain] Cd Length: 169 Bit Score: 53.31 E-value: 2.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 36 GGLEKVVLDSAIAFDRSRFDVTIVTPGKVGHLGTVARDaGLRVVGLPAGNP---------LSAYERVLAEDGIDIAMSHF 106
Cdd:pfam13439 1 GGVERYVLELARALARRGHEVTVVTPGGPGPLAEEVVR-VVRVPRVPLPLPprllrslafLRRLRRLLRRERPDVVHAHS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 107 SDTGYP----LFEKFRIPNVTYIHNVYAFFSEAQARAFADND----------RYVERYVSVSRNATRFAVHNLGVPEAKV 172
Cdd:pfam13439 80 PFPLGLaalaARLRLGIPLVVTYHGLFPDYKRLGARLSPLRRllrrlerrllRRADRVIAVSEAVADELRRLYGVPPEKI 159
|
....*.
gi 738089395 173 ETIPNG 178
Cdd:pfam13439 160 RVIPNG 165
|
|
| GT4_ExpE7-like |
cd03823 |
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ... |
36-387 |
4.29e-08 |
|
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).
Pssm-ID: 340850 [Multi-domain] Cd Length: 357 Bit Score: 54.64 E-value: 4.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 36 GGLEKVVLDSAIAFDRSRFDVTIVTPGkVGHLGTVARDAGLRVVGLPAGNPLSA--------------------YERVLA 95
Cdd:cd03823 15 GGAEISVHDLAEALVAEGHEVAVLTAG-VGPPGQATVARSVVRYRRAPDETLPLalkrrgyelfetynpglrrlLARLLE 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 96 EDGIDIAMSHfSDTGYPL-----FEKFRIPNVTYIHNvYAFFSEAQARAFADNDRYVeryvSVSRnATRFAVHNLGVPEA 170
Cdd:cd03823 94 DFRPDVVHTH-NLSGLGAslldaARDLGIPVVHTLHD-YWLLCPRQFLFKKGGDAVL----APSR-FTANLHEANGLFSA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 171 KVETIPNGLIlSEHEAREKLTQTLTRAelgladtdyVFANVASYNLHKGHYLMADAMRHLlaRRRDVKILCVGnvvyppH 250
Cdd:cd03823 167 RISVIPNAVE-PDLAPPPRRRPGTERL---------RFGYIGRLTEEKGIDLLVEAFKRL--PREDIELVIAG------H 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 251 VDALRAYLDEQGLSGHILmpGYV--ADVAAVHRIADAFLLPS-FIEGWSIAMNEAMFYRKPMVLSDTGASAEVIEQDDIG 327
Cdd:cd03823 229 GPLSDERQIEGGRRIAFL--GRVptDDIKDFYEKIDVLVVPSiWPEPFGLVVREAIAAGLPVIASDLGGIAELIQPGVNG 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 328 ILVPneYGDTielnskrlDELAYAPHQYRTAPILADALERMASNRDEWRERgARGRDKIY 387
Cdd:cd03823 307 LLFA--PGDA--------EDLAAAMRRLLTDPALLERLRAGAEPPRSTESQ-AEEYLKLY 355
|
|
| PRK15179 |
PRK15179 |
Vi polysaccharide biosynthesis protein TviE; Provisional |
144-372 |
7.24e-08 |
|
Vi polysaccharide biosynthesis protein TviE; Provisional
Pssm-ID: 185101 [Multi-domain] Cd Length: 694 Bit Score: 54.65 E-value: 7.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 144 DRYVERY------------VSVSRNaTRFAVHN----LGVPEAKVETIPNGLILSEHEAREKLTQTLTRAELGLADTDYV 207
Cdd:PRK15179 441 DRYRVEYdiiysellkmrgVALSSN-SQFAAHRyadwLGVDERRIPVVYNGLAPLKSVQDDACTAMMAQFDARTSDARFT 519
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 208 FANVASYNLHKGHYLMADAMRHLLARRRDVKILCVGNvvyPPHVDALRAYLDEQGLSGHILMPGYVADVAAVHRIADAFL 287
Cdd:PRK15179 520 VGTVMRVDDNKRPFLWVEAAQRFAASHPKVRFIMVGG---GPLLESVREFAQRLGMGERILFTGLSRRVGYWLTQFNAFL 596
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 288 LPSFIEGWSIAMNEAMFYRKPMVLSDTGASAEVIEQDDIGILVPNEYGDTIELNskrlDELAYAPHQYRTAPILADALER 367
Cdd:PRK15179 597 LLSRFEGLPNVLIEAQFSGVPVVTTLAGGAGEAVQEGVTGLTLPADTVTAPDVA----EALARIHDMCAADPGIARKAAD 672
|
....*
gi 738089395 368 MASNR 372
Cdd:PRK15179 673 WASAR 677
|
|
| GT4-like |
cd05844 |
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ... |
61-402 |
2.45e-07 |
|
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
Pssm-ID: 340860 [Multi-domain] Cd Length: 365 Bit Score: 52.45 E-value: 2.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 61 PGKVGHLGTVARDAGLRVVGLPAGNPLSAYERVLAEDGIDIAMSHFSDTG---YPLFEKFRIPNVTYIHNVYAFFSEAQA 137
Cdd:cd05844 44 GVALRALGGSGPLRWLRQMAQRLLGWSAPRLGGAAGLAPALVHAHFGRDGvyaLPLARALGVPLVVTFHGFDITTSRAWL 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 138 RAFADNDRYVER-----------YVSVSRnATRFAVHNLGVPEAKVETIPNGLILSEhearekltqtLTRAELGlADTDY 206
Cdd:cd05844 124 AASPGWPSQFQRhrralqrpaalFVAVSG-FIRDRLLARGLPAERIHVHYIGIDPAK----------FAPRDPA-ERAPT 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 207 vFANVASYNLHKGHYLMADAMRHLLARRRDVKILCVGNVVYPPHVDALRAYLDE---QGLSGHilmpgyvADVAAVHRIA 283
Cdd:cd05844 192 -ILFVGRLVEKKGCDVLIEAFRRLAARHPTARLVIAGDGPLRPALQALAAALGRvrfLGALPH-------AEVQDWMRRA 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 284 DAFLLPSFI------EGWSIAMNEAMFYRKPMVLSDTGASAEVIEQDDIGILVPNeygdtielnskrldelayaphqyRT 357
Cdd:cd05844 264 EIFCLPSVTaasgdsEGLGIVLLEAAACGVPVVSSRHGGIPEAILDGETGFLVPE-----------------------GD 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 738089395 358 APILADALERMASNRDEWRERGARGRDKIYAHYDFTEIVARYEAL 402
Cdd:cd05844 321 VDALADALQALLADRALADRMGGAARAFVCEQFDIRVQTAKLEAI 365
|
|
| MSMEG_0565_glyc |
TIGR04047 |
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ... |
43-313 |
2.63e-07 |
|
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 274943 [Multi-domain] Cd Length: 373 Bit Score: 52.40 E-value: 2.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 43 LDSAIAFDRSRFDVTIVTPGKVGhlGTVARDAGLRVVGLPAGnPLSAYERVLAEDGIDIAMSHFSDTGYPLFEKF----- 117
Cdd:TIGR04047 19 LELAEALTALGHDVTVWALAADG--FGFFRDPPCAVRLVPVA-PAPGDTDAMVEQRIARSIDHLRAHFARGFDVVhaqdc 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 118 -------------RIPN-VTYIHNVYAFFSEA----QARAFADNDRYVeryvSVSRNATRFAVHNLGVpEAKVetIPNGL 179
Cdd:TIGR04047 96 isgnalatlraegLIPGfVRTVHHLDDFDDPRlaacQERAIVEADAVL----CVSAAWAAELRAEWGI-DATV--VPNGV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 180 ILSEHEAREKLTQTLTRAELGLADTDYVFAnVASYNLHKGHYLMADAMRHLLARRRDVKILCVGNVV---YPPHVDALRA 256
Cdd:TIGR04047 169 DAARFSPAADAADAALRRRLGLRGGPYVLA-VGGIEPRKNTIDLLEAFALLRARRPQAQLVIAGGATlfdYDAYRREFRA 247
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 257 YLDEQGLS-GHILMPGYVADVA--AVHRIADAFLLPSFIEGWSIAMNEAMFYRKPMVLSD 313
Cdd:TIGR04047 248 RAAELGVDpGPVVITGPVPDADlpALYRCADAFAFPSLKEGFGLVVLEALASGIPVVASD 307
|
|
| GT4_UGDG-like |
cd03817 |
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ... |
79-371 |
1.32e-06 |
|
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.
Pssm-ID: 340844 [Multi-domain] Cd Length: 372 Bit Score: 49.97 E-value: 1.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 79 VGLPAGNPlSAYERVLAEDGIDI--AMSHFS--DTGYPLFEKFRIPNVTYIHNVYAFFSEAQARAFADNDRYVERYVSVS 154
Cdd:cd03817 66 QHIPFPFK-KAVIDRIKELGPDIihTHTPFSlgKLGLRIARKLKIPIVHTYHTMYEDYLHYIPKGKLLVKAVVRKLVRRF 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 155 RNATRfAVH-----------NLGVpEAKVETIPNGLilsEHEAREKLTQTLTRAELGLADTDYVFANVASYNLHKGHYLM 223
Cdd:cd03817 145 YNHTD-AVIapsekikdtlrEYGV-KGPIEVIPNGI---DLDKFEKPLNTEERRKLGLPPDEPILLYVGRLAKEKNIDFL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 224 ADAMrHLLARRRDVKILCVGNVVYPPHVDALRAYLdeqGLSGHILMPGYV--ADVAAVHRIADAFLLPSFIEGWSIAMNE 301
Cdd:cd03817 220 LRAF-AELKKEPNIKLVIVGDGPEREELKELAREL---GLADKVIFTGFVprEELPEYYKAADLFVFASTTETQGLVYLE 295
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738089395 302 AMFYRKPMVLSDTGASAEVIEQDDIGILVPN------EYGDTIELNSKRLDELAYAPHQYRTAPILADALERMASN 371
Cdd:cd03817 296 AMAAGLPVVAAKDPAASELVEDGENGFLFEPndetlaEKLLHLRENLELLRKLSKNAEISAREFAFAKSVEKLYEE 371
|
|
| PRK15484 |
PRK15484 |
lipopolysaccharide N-acetylglucosaminyltransferase; |
167-405 |
6.88e-06 |
|
lipopolysaccharide N-acetylglucosaminyltransferase;
Pssm-ID: 185381 [Multi-domain] Cd Length: 380 Bit Score: 47.86 E-value: 6.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 167 VPEAKVETIPNGLILsehEAREKLTQTLTRAELGLADTDYVFANVASYNLHKGHYLMADAMRHLLARRRDVKILCVGNVV 246
Cdd:PRK15484 158 LPNADISIVPNGFCL---ETYQSNPQPNLRQQLNISPDETVLLYAGRISPDKGILLLMQAFEKLATAHSNLKLVVVGDPT 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 247 YPPHVDAL---RAYLDE-QGLSGHILMPGYVA--DVAAVHRIADAFLLPS-FIEGWSIAMNEAMFYRKPMVLSDTGASAE 319
Cdd:PRK15484 235 ASSKGEKAayqKKVLEAaKRIGDRCIMLGGQPpeKMHNYYPLADLVVVPSqVEEAFCMVAVEAMAAGKPVLASTKGGITE 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 320 VIEQDDIGilvpneygdtielnskrldelaYAPHQYRTAPILADALERMASNRDEwRERGARGRDKIYAHYDFTEIVARY 399
Cdd:PRK15484 315 FVLEGITG----------------------YHLAEPMTSDSIISDINRTLADPEL-TQIAEQAKDFVFSKYSWEGVTQRF 371
|
....*.
gi 738089395 400 EALIED 405
Cdd:PRK15484 372 EEQIHN 377
|
|
| GT4_WfcD-like |
cd03795 |
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ... |
34-357 |
9.44e-06 |
|
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.
Pssm-ID: 340826 [Multi-domain] Cd Length: 355 Bit Score: 47.27 E-value: 9.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 34 DKGGLEKVVLDSAIAFDRSRFDVTIVT----PGKVGHLGTVARDAGLRVVGLPAGNPLS-AYERVLAE--DGIDIAMSHF 106
Cdd:cd03795 12 DIGGIEQVIYDLAEGLKKKGIEVDVLCfskeKETPEKEENGIRIHRVKSFLNVASTPFSpSYIKRFKKlaKEYDIIHYHF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 107 SdtgYPL------FEKFRIPNVTYIHN-------VYAFFSEAQARAFADNDRYV---ERYVSVSRNATRFavhnlgvpEA 170
Cdd:cd03795 92 P---NPLadlllfFSGAKKPVVVHWHSdivkqkkLLKLYKPLMTRFLRRADRIIatsPNYVETSPTLREF--------KN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 171 KVETIPNGLILSEHEAREKLTQTLTRAELGladtDYVFANVASYNLHKG-HYLMaDAMRHLlarrrDVKILCVGnvvypp 249
Cdd:cd03795 161 KVRVIPLGIDKNVYNIPRVDFENIKREKKG----KKIFLFIGRLVYYKGlDYLI-EAAQYL-----NYPIVIGG------ 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 250 hVDALRAYLDEQ---GLSGHILMPGYVADVAAVH--RIADAFLLPSFI--EGWSIAMNEAMFYRKPMVLSDTGASAEVIE 322
Cdd:cd03795 225 -EGPLKPDLEAQielNLLDNVKFLGRVDDEEKVIylHLCDVFVFPSVLrsEAFGIVLLEAMMCGKPVISTNIGTGVPYVN 303
|
330 340 350
....*....|....*....|....*....|....*.
gi 738089395 323 QDDI-GILVPNeyGDTIELnSKRLDELAYAPHQYRT 357
Cdd:cd03795 304 NNGEtGLVVPP--KDPDAL-AEAIDKLLSDEELRES 336
|
|
| GT4-like |
cd03813 |
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ... |
145-399 |
5.59e-05 |
|
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.
Pssm-ID: 340841 [Multi-domain] Cd Length: 474 Bit Score: 45.02 E-value: 5.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 145 RYVERYVSVSRNATRFAVHnLGVPEAKVETIPNGL-------ILSEHEAREKLTqtltraeLGLadtdyvfanVASYNLH 217
Cdd:cd03813 243 QQADKIISLYEGNRRRQIR-LGADPDKTRVIPNGIdiqrfapAREERPEKEPPV-------VGL---------VGRVVPI 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 218 KGHYLMADAMRHLLARRRDVKILCVG----NVVYPPHVDALRAYLdeqGLSGHILMPGyVADVAAVHRIADAFLLPSFIE 293
Cdd:cd03813 306 KDVKTFIRAFKLVRRAMPDAEGWLIGpedeDPEYAQECKRLVASL---GLENKVKFLG-FQNIKEYYPKLGLLVLTSISE 381
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 294 GWSIAMNEAMFYRKPMVLSDTGASAEVIE-QDDI----GILVPneygdtielnskrldelayaPHQYRTapiLADALERM 368
Cdd:cd03813 382 GQPLVILEAMASGVPVVATDVGSCRELIYgADDAlgqaGLVVP--------------------PADPEA---LAEALIKL 438
|
250 260 270
....*....|....*....|....*....|.
gi 738089395 369 ASNRDEWRERGARGRDKIYAHYDFTEIVARY 399
Cdd:cd03813 439 LRDPELRQAFGEAGRKRVEKYYTLEGMIDSY 469
|
|
| GT4_AviGT4-like |
cd03802 |
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ... |
36-333 |
7.23e-05 |
|
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.
Pssm-ID: 340832 [Multi-domain] Cd Length: 333 Bit Score: 44.59 E-value: 7.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 36 GGLEKVVLDSAIAFDRSRFDVTIVTPGKVGHLG------TVARDAGLRVVGLPAGNPLSAYERVLAEDGIDIAMSHFSDT 109
Cdd:cd03802 18 GGTELVVSALTEGLVRRGHEVTLFAPGDSHTSAplvaviPRALRLDPIPQESKLAELLEALEVQLRASDFDVIHNHSYDW 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 110 GYPLFEKFRIPNVTYIHnvyaFFSEAQARAFADNDRYVeRYVSVSRNAtrfAVHNLGVPEAKVetIPNGLilsehearek 189
Cdd:cd03802 98 LPPFAPLIGTPFVTTLH----GPSIPPSLAIYAAEPPV-NYVSISDAQ---RAATPPIDYLTV--VHNGL---------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 190 ltqtltraelglADTDYVFANVASYNLH--------KGhylMADAMRhlLARRRDVKILCVGNVVYPPHVDalraYLDEQ 261
Cdd:cd03802 158 ------------DPADYRFQPDPEDYLAflgriapeKG---LEDAIR--VARRAGLPLKIAGKVRDEDYFY----YLQEP 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 738089395 262 GLSGHILMPGYVADVAAVHRIADAFLL---PSFIEGWSIAMNEAMFYRKPMVLSDTGASAEVIEQDDIGILVPNE 333
Cdd:cd03802 217 LPGPRIEFIGEVGHDEKQELLGGARALlfpINWDEPFGLVMIEAMACGTPVIAYRRGGLPEVIQHGETGFLVDSV 291
|
|
| GT4_ExpC-like |
cd03818 |
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 ... |
230-401 |
3.47e-04 |
|
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II).
Pssm-ID: 340845 [Multi-domain] Cd Length: 396 Bit Score: 42.35 E-value: 3.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 230 LLARRRDVKILCVGN--VVY---PPHVDALRAYLDEQgLSG---HILMPGYV--ADVAAVHRIADA--FLLPSFIEGWSi 297
Cdd:cd03818 239 IQARRPDARVVVVGGdgVSYgspPPDGGSWKQKMLAE-LGVdleRVHFVGKVpyDQYVRLLQLSDAhvYLTYPFVLSWS- 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 298 aMNEAMFYRKPMVLSDTGASAEVIEQDDIGILVPneYGDTIELNSKRLDELAyaphqyrtapiladalermasNRDEWRE 377
Cdd:cd03818 317 -LLEAMACGCPVIGSDTAPVREVIRDGRNGLLVD--FFDPDALAAAVLELLE---------------------DPDRAAA 372
|
170 180
....*....|....*....|....
gi 738089395 378 RGARGRDKIYAHYDFTEIVARYEA 401
Cdd:cd03818 373 LRRAARRTVERSDSLDVCLARYLA 396
|
|
| Glyco_trans_4_4 |
pfam13579 |
Glycosyl transferase 4-like domain; |
36-178 |
3.49e-04 |
|
Glycosyl transferase 4-like domain;
Pssm-ID: 433325 [Multi-domain] Cd Length: 158 Bit Score: 40.85 E-value: 3.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 36 GGLEKVVLDSAIAFDRSRFDVTIVTPGKVGhLGTVARDAGLRVVGLPAGNP---------LSAYERVLAEDGIDIAMSHF 106
Cdd:pfam13579 1 GGIGVYVLELARALAALGHEVRVVTPGGPP-GRPELVGDGVRVHRLPVPPRpspladlaaLRRLRRLLRAERPDVVHAHS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 107 SDTGYPLFEKFRIPNVTYIHNVYAFFSEAQARAFADNDRYVERYVSvsRNATRF---------AVHNLGVPEAKVETIPN 177
Cdd:pfam13579 80 PTAGLAARLARRRRGVPLVVTVHGLALDYGSGWKRRLARALERRLL--RRADAVvvvseaeaeLLRALGVPAARVVVVPN 157
|
.
gi 738089395 178 G 178
Cdd:pfam13579 158 G 158
|
|
| GT4_AmsK-like |
cd03799 |
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ... |
283-391 |
5.05e-03 |
|
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.
Pssm-ID: 340829 [Multi-domain] Cd Length: 350 Bit Score: 38.59 E-value: 5.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738089395 283 ADAFLLPSFI------EGWSIAMNEAMFYRKPMVLSDTGASAEVIEQDDIGILVPNeygdtielnskrldelayaphqyR 356
Cdd:cd03799 251 ADIFIAPSVTaadgdqDGPPNTLKEAMAMGLPVISTEHGGIPELVEDGVSGFLVPE-----------------------R 307
|
90 100 110
....*....|....*....|....*....|....*
gi 738089395 357 TAPILADALERMASNRDEWRERGARGRDKIYAHYD 391
Cdd:cd03799 308 DAEAIAEKLTYLIEHPAIWPEMGKAGRARVEEEYD 342
|
|
| |
