|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
2-410 |
4.09e-157 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 449.67 E-value: 4.09e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 2 RKLIIGSFLGNSLEWYDFFLYGTAAALVFGSLFFPvQDDPLISTLLAFSGFAVGFIARPLGGILFGHIGDKYSRKTTLII 81
Cdd:cd17369 1 RRVALASLVGTAIEWYDFFIYGTAAALVFNKLFFP-AVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 82 TLTLMGASTFLIGLLPTWHQVGVLAPIALISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSAL 161
Cdd:cd17369 80 TLLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 162 AFWLV-QLLPENAFMTWGWRIPFLMSVFIFLVGIYIRKNIRENKEFTQLKQASDTepeANVPVIEIFKKYPKQLLQAIGL 240
Cdd:cd17369 160 VFLLLsALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQV---VRAPLVEVLRRHWRALLLAIGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 241 RLPENGAVYIFFTFSVVFC-KHVGIASDKIIAVVTLAMMLEIFSILFWGWLSDRIGRKTIYYIGVIGLLLTAFPFFSLLA 319
Cdd:cd17369 237 RLAENVLFYLFTTFALSYAtQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLD 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 320 SGNFSLMMLAMMLGLPLCHGAMIAAQPCIMSELFPVEVRYTGLALGHEIGAVISGGISPMIAVALLLKYDHWWPISVMLL 399
Cdd:cd17369 317 TGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAATGSWWPVALYLA 396
|
410
....*....|.
gi 738157309 400 GFALVALIALL 410
Cdd:cd17369 397 ALAVISLVAAL 407
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
11-406 |
4.43e-114 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 339.63 E-value: 4.43e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 11 GNSLEWYDFFLYGTAAALVFGSLFFPvQDDPLISTLLAFSGFAVGFIARPLGGILFGHIGDKYSRKTTLIITLTLMGAST 90
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPP-SGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 91 FLIGLLPTWHQVGVLAPIALISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSALAFWLV-QLL 169
Cdd:TIGR00883 80 LLIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLsYLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 170 PENAFMTWGWRIPFLMSVFIFLVGIYIRKNIRENKEFTQLKQASDTepeANVPVIEIFKKYPKQLLQAIGLRLPENGAVY 249
Cdd:TIGR00883 160 GDDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKK---KRGPIAETLTKHRKPFLLGLGLVIATTTTFY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 250 IFFTFSVVFCKHV-GIASDKIIAVVTLAMMLEIFSILFWGWLSDRIGRKTIYYIGVIGLLLTAFPFFSLLASGNFSLMML 328
Cdd:TIGR00883 237 LITTYLPTYLTQTlGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALLDSGSFTLFF 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 738157309 329 AMMLGLPLCHGAMIAAQPCIMSELFPVEVRYTGLALGHEIGAVISGGISPMIAVALLLKYDHWWPISVMLLGFALVAL 406
Cdd:TIGR00883 317 FLVLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGDWYAIGYYLAALALIGL 394
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
2-418 |
2.95e-98 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 300.50 E-value: 2.95e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 2 RKLIIGSFLGNSLEWYDFFLYGTAAALVFGSLFFPvQDDPLISTLLAFSGFAVGFIARPLGGILFGHIGDKYSRKTTLII 81
Cdd:PRK09952 21 RRAALGSFAGAVVDWYDFLLYGITAALVFNREFFP-QVSPAMGTLAAFATFGVGFLFRPLGGVVFGHFGDRLGRKRMLML 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 82 TLTLMGASTFLIGLLPTWHQVGVLAPIALISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLS-A 160
Cdd:PRK09952 100 TVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLLStG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 161 LAFWLVQLLPENAFMTWGWRIPFLMSVFIFLVGIYIRKNIRENKEFTQlKQASDTEPEANVPVIEIFKKYPKQLLQAIGL 240
Cdd:PRK09952 180 LVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQ-QQHEQAAAKKRIPVIEALLRHPGAFLKIIAL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 241 RLPENGAVYIFFTFSVVF-CKHVGIASDKIIAVVTLAMMLEIFSILFWGWLSDRIGRKTIYYIGVIGLLLTAFPFFSLLA 319
Cdd:PRK09952 259 RLCELLTMYIVTAFALNYsTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFFMALE 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 320 SGNFSLMMLAMMLGLPLCHGAMIAAQPCIMSELFPVEVRYTGLALGHEIGAVISGGISPMIAVALL-LKYDHWWPISVML 398
Cdd:PRK09952 339 AQSIFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVtYFGGSWHSVAIYL 418
|
410 420
....*....|....*....|
gi 738157309 399 LGFALVALIALLSIKVSPRA 418
Cdd:PRK09952 419 LAGCLISAMTALLMKDNQRA 438
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
5-415 |
1.14e-76 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 243.03 E-value: 1.14e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 5 IIGSFLGNSLEWYDFFLYGTAAALVfGSLFFPVqDDPLISTLLAFSGFAVGFIARPLGGILFGHIGDKYSRKTTLIITLT 84
Cdd:cd17366 1 VKAAALGNAMEWFDFGVYGYLAVTI-GKVFFPG-GDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITII 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 85 LMGASTFLIGLLPTWHQVGVLAPIALISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVL-SALAF 163
Cdd:cd17366 79 LMAASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILgAGLVT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 164 WLVQLLPENAFMTWGWRIPFLMSVFIFLVGIYIRknirenkeftqlkqasdtepeanvpvieifkkypKQLLQAIGLRLP 243
Cdd:cd17366 159 LLTLLLTEAQMLDWGWRIPFLIAAPLGLVGLYLR----------------------------------RPLLICIGLVLV 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 244 ENGAVYIFFTF-SVVFCKHVGIASDKIIAVVTLAMMLEIFSILFWGWLSDRIGRKTIYYIGVIGLLLTAFPFFSLLASGN 322
Cdd:cd17366 205 FNVTNYMLLSYmPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGS 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 323 FSLMMLAMMLGLPLcHGAMIAAQPCIMSELFPVEVRYTGLALGHEIGAVISGGISPMIAVALLLKYDHWWPISVMLLGFA 402
Cdd:cd17366 285 IAAIFIGLLVLGLL-LSCYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATGNPLMPAYYLMVAA 363
|
410
....*....|...
gi 738157309 403 LVALIALLSIKVS 415
Cdd:cd17366 364 VVGLVAVLFLTET 376
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
5-384 |
3.62e-71 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 229.87 E-value: 3.62e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 5 IIGSFLGNSLEWYDFFLYGtAAALVFGSLFFPvQDDPLISTLLAFSGFAVGFIARPLGGILFGHIGDKYSRKTTLIITLT 84
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYA-AFALYFAPQFFP-SGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 85 LMGASTFLIGLLPTWHQVGVLAPIALISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVL-SALAF 163
Cdd:cd17367 79 LMAAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLaLGVLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 164 WLVQLLPENAFMTWGWRIPFLMSVFIFLVGIYIRKNIRENKEFtqlkQASDTEPEANVPVIEIFKKYPKQLLQAIGLRLP 243
Cdd:cd17367 159 VLQHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESF----EAIAESNEASAGTLRELRRHPRELLLVVGLTAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 244 ENGAVYIFFTFSVVFCKH-VGIASDKIIAVVTLAMMLEIFSILFWGWLSDRIGRKTIYYIGVIGLLLTAFPFFSLLASGN 322
Cdd:cd17367 235 GTLAFYTWTTYLQKFLVNtAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTD 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 738157309 323 FSLMMLAMMLGLPLCHGAMIAAQPCIMSELFPVEVRYTGLALGHEIGAVISGGISPMIAVAL 384
Cdd:cd17367 315 SPYTAFALVLVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALWL 376
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
1-413 |
5.35e-68 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 223.82 E-value: 5.35e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 1 MRKLIIGSFLGNSLEWYDFFLYGTAAaLVFGSLFFPvQDDPLISTLLAFSGFAVGFIARPLGGILFGHIGDKYSRKTTLI 80
Cdd:PRK10642 14 LRKAITAASLGNAMEWFDFGVYGFVA-YALGKVFFP-GADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 81 ITLTLMGASTFLIGLLPTWHQVGVLAPIALISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSA 160
Cdd:PRK10642 92 ITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 161 LAFWLVQ-LLPENAFMTWGWRIPFLMSVFIFLVGIYIRKNIRENKEFTQLKQASDTEPEAN------VPVIEIFKKYPKQ 233
Cdd:PRK10642 172 GVVVLIStIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQQHVDKLEQGDREGlqdgpkVSFKEIATKHWRS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 234 LLQAIGLRLPENGAVYIFFTFSVVFCKH-VGIASDKIIAVVTLAMMLEIFSILFWGWLSDRIGRKTIYYIGVIGLLLTAF 312
Cdd:PRK10642 252 LLTCIGLVIATNVTYYMLLTYMPSYLSHnLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFVILGSVALFVLAI 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 313 PFFSLLASGNFSLMMLAMMLGLPLCHgAMIAAQPCIMSELFPVEVRYTGLALGHEIGAVISgGISPMIAVALLLKYDHWW 392
Cdd:PRK10642 332 PAFILINSNVIGLIFAGLLMLAVILN-CFTGVMASTLPAMFPTHIRYSALAAAFNISVLVA-GLTPTLAAWLVESTQNLM 409
|
410 420
....*....|....*....|.
gi 738157309 393 PISVMLLGFALVALIALLSIK 413
Cdd:PRK10642 410 MPAYYLMVVAVIGLITGVTMK 430
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
5-414 |
4.51e-61 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 203.37 E-value: 4.51e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 5 IIGSFLGNSLEWYDFFLYGTAAALVfGSLFFPvQDDPLISTLLAFSGFAVGFIARPLGGILFGHIGDKYSRKTTLIITLT 84
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYI-GRLFFP-SGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 85 LMGASTFLIGLLPTWHQVGVLAPIALISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSALAFW 164
Cdd:cd17368 79 IMALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGY 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 165 LVQL-LPENAFMTWGWRIPFLMSVFIFLVGIYIRKNIRENKEFTQLKQASDTEpeanvPVIEIFKKYPKQLLQAIGLRLP 243
Cdd:cd17368 159 LLSLtLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPTRR-----ELFALLANNRRIILLGMLLVAG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 244 ENGAVYIFFTFSVVFCKHV-GIASDKIIAVVTLAMMLEIFSILFWGWLSDRIGRKTIYYIGVIGLLLTAFPFFSLLASGN 322
Cdd:cd17368 234 STVTFYFTTVYTPTYAKTVlGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAP 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 323 FSLMMLAMMLGLPLCHGAMIAAQPCIMSELFPVEVRYTGLALGHEIGAVISGGISPMIAVALLLKYDHWWPISVMLLGFA 402
Cdd:cd17368 314 SFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIELTGSPLAPAWYLMGAA 393
|
410
....*....|..
gi 738157309 403 LVALIALLSIKV 414
Cdd:cd17368 394 LLGLLATLMLRE 405
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
5-410 |
3.58e-56 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 188.96 E-value: 3.58e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 5 IIGSFLGNSLEWYDFFLYGTAAALVFGSLFFPvqddplISTLLAFSGFAVGFIARPLGGILFGHIGDKYSRKTTLIITLT 84
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLG------LSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 85 LMGASTFLIGLLPTwhqvgvlaPIALISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSALAFW 164
Cdd:cd17316 75 LFGLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVAS 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 165 LVQLLPENafmTWGWRIPFLMSVFIFLVGIYIRKNIrenkeftqlkqasdtepeanvpvieifkkypkqlLQAIGLRLPE 244
Cdd:cd17316 147 LLIPLLSG---DWGWRILFLIGALPALLALLLRRRT----------------------------------LLLILLWFFI 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 245 NGAVYIFFTFSVVFCKHV-GIASDKIIAVVTLAMMLEIFSILFWGWLSDRIGRKTIYYIGVIGLLLTAFPFFSLLASGnf 323
Cdd:cd17316 190 SFGYYGLTTFLPTYLQTVlGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGS-- 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 324 SLMMLAMMLGLPLCHGAMIAAQPCIMSELFPVEVRYTGLALGHEIGAVIsGGISPMIAVALLLKYDHWWPISVMLLGFAL 403
Cdd:cd17316 268 PTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLG-GGGAPPLIALLLASTGGTGVPALILALLAI 346
|
....*..
gi 738157309 404 VALIALL 410
Cdd:cd17316 347 VALIVAL 353
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
11-384 |
6.94e-54 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 185.15 E-value: 6.94e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 11 GNSLEWYDFFLYGTAAALVfGSLFFPVqDDPLISTLLAFSGFAVGFIARPLGGILFGHIGDKYSRKTTLIITLTLMGAST 90
Cdd:PRK15075 23 GNFLEMFDFFLFGFYATAI-AKTFFPA-GNEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTLSIMASGT 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 91 FLIGLLPTWHQVGVLAPIALISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAW----SQVGVsggFVLSALAFWLV 166
Cdd:PRK15075 101 LLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWqsasQQVAV---VFAALLGYLLN 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 167 QLLPENAFMTWGWRIPFLMSVFIFLVGIYIRKNIRENKEFTQLKQASDTEpeanvpviEIFKKYPKQ---LLQAIGLRLP 243
Cdd:PRK15075 178 QWLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFLARKHRPSMR--------EIFRSLAANwriVLAGMLMVAM 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 244 ENGAVYIFFTFSVVFCKHVGIASDKIIAVVTLAMMLeifSILFW----GWLSDRIGRKTIYYIGVIGLLLTAFPFFSLLA 319
Cdd:PRK15075 250 TTVSFYLITVYTPTFGKTVLHLSAADSLLVTLCVGV---SNFIWlpigGALSDRIGRRPVLIAFTVLAILTAYPALSWLV 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 738157309 320 S----GNFSLMMLAMMLGLPLCHGAMIAAqpciMSELFPVEVRYTGLALGHEIGAVISGGISPMIAVAL 384
Cdd:PRK15075 327 AapsfARMLAVELWLSFLYGSYNGAMVVA----LTEVMPAEVRTAGFSLAYSLATAIFGGFTPAISTWL 391
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
5-406 |
2.93e-44 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 159.59 E-value: 2.93e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 5 IIGSFLGNSLEWYDFFLYgTAAALVFGSLFFPvQDDPLISTLLAFSGFAVGFIARPLGGILFGHIGDKYSRKTTLIITLT 84
Cdd:PRK10406 24 IVGASSGNLVEWFDFYVY-SFCSLYFAHIFFP-SGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLISVC 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 85 LMGASTFLIGLLPTWHQVGVLAPIALISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSALAF- 163
Cdd:PRK10406 102 MMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVv 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 164 WLVQLLPENAFMTWGWRIPFLMSVFIFLVGIYIRKNIRE--NKEFTQLKQASDtepeanvpvIEIFKKYPKQLLQAIGLr 241
Cdd:PRK10406 182 VLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDEtsQQETRALKEAGS---------LKGLWRNRRAFIMVLGF- 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 242 lpENGAVYIFFTFSVVFCKHV----GIASDKIIAVVTLAMMLEIFSILFWGWLSDRIGRKT-IYYIGVIGLLLTAfPFFS 316
Cdd:PRK10406 252 --TAAGSLCFYTFTTYMQKYLvntaGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTsMLCFGSLAALFTV-PILS 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 317 LLASGNFSLMMLAMMLGLPLCHGAMIAAQPCIMSELFPVEVRYTGLALGHEIGAVISGGISPMIAVALL---LKYDHWWP 393
Cdd:PRK10406 329 ALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANALFGGSAEYVALSLKsigMETAFFWY 408
|
410
....*....|...
gi 738157309 394 ISVMLLGFALVAL 406
Cdd:PRK10406 409 VTLMAVVAFLVSL 421
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-206 |
1.87e-24 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 102.20 E-value: 1.87e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 2 RKLIIGSFLGNSLEWYDFFLYGTAAALVFGSLFFPVQDDPLIstllafsgFAVGFIARPLGGILFGHIGDKYSRKTTLII 81
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWI--------VSAYLLGRAIGLLLFGRLGDRYGRKRVLLI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 82 TLTLMGASTFLIGLLPTwhqvgvlaPIALISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSAL 161
Cdd:COG0477 85 GLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPL 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 738157309 162 AFWLVqllpenaFMTWGWRIPFLMSVFIFLVGIYIRKNIRENKEF 206
Cdd:COG0477 157 LGGLL-------VAALGWRWIFLINAPLGLLALVLRLRLPESRGL 194
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
2-418 |
6.07e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 102.65 E-value: 6.07e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 2 RKLIIGSFLGNSLEWYDFFLYGTAAAlvfgslffPVQDDPLISTLLAFSGFAVGFIARPLGGILFGHIGDKYSRKTTLII 81
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAP--------PLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 82 TLTLMGASTFLIGLLPTWhqvgvlapIALISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSAL 161
Cdd:COG2223 76 GLLLLGIGLLLLALAVSY--------WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAF 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 162 AFWLVqllpenaFMTWGWRIPFL-MSVFIFLVGIYIRKNIRENKEFtqlkqASDTEPEANVPVIEIFKKypKQLLQAIGL 240
Cdd:COG2223 148 LAPLL-------IAAFGWRNAFLiLGILLLVVAVLAWLFLRDPPAG-----AAAAAKASLRDQLEALRD--PRFWLLSLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 241 RLPENGAVYIFFTFSVVFCKHV-GIASDKIIAVVTLAMMLEIFSILFWGWLSDRIGRKTIYYIGVIGLLLTAFPFFSLLA 319
Cdd:COG2223 214 YFGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 320 SgnfSLMMLAMMLGLPLCHGAMIAAQPCIMSELFPVEVRYTGLALGHEIGAvISGGISPMIAVALLLKYDHWWPISVMLL 399
Cdd:COG2223 294 S---LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGG-LGGFLGPLLFGALLDATGSYTAAFLVFA 369
|
410
....*....|....*....
gi 738157309 400 GFALVALIALLSIKVSPRA 418
Cdd:COG2223 370 VLALVALVLTLLLYRRPRR 388
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
6-414 |
3.31e-23 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 100.45 E-value: 3.31e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 6 IGSFLGNSLEWYDFFLYGT---AAALVFGSlfFPVQDDPLISTLLAFSGFavgfiarplGGILFGHIGDKYSRKTTLIIT 82
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLvlpALIAEFGL--DEAEAGLLGTVTLAGGAI---------GGILGGILADRFGRVRVLVIT 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 83 LTLMGASTFLIGLLPTWHQVGVlapialisLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVS-GGFVLSAL 161
Cdd:cd17371 71 ILLFAVFTLLCGFAQNYWQLLI--------LRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAvGWLLATLL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 162 AFWLVQLLPENafmtWGWRIPFLMSVFIFLVGIYIRKNIRENKEFTQlKQASDTEPEANVPVIEIFKkyPKQLLQAIGLR 241
Cdd:cd17371 143 AALLFPLLPPE----IAWRVLFLLGALPALLVLFIRRFVKEPPQWQA-ARAARRHFADRPSLRELFS--PPLLRTTLLAS 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 242 LPENGAVYIFFTFSVVFCKHVGIASDKIIAVVTLAMMLEIFS----ILFWGWLSDRIGRKTIYYIGVIGLLLTAFPFFSL 317
Cdd:cd17371 216 LLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGgflgYLAGGFLADRIGRRNNFALFALGSAISILLYFFL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 318 LASgnfSLMMLAMMLGLPLCHGAMIAAQPCIMSELFPVEVRYTGLALGHEIGAVIsGGISPMIAVALLLKYDHWWPISVM 397
Cdd:cd17371 296 PLS---PTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRII-GALFPFLVGFLATSGSLGTAIAVF 371
|
410
....*....|....*..
gi 738157309 398 LLGFALVALIALLSIKV 414
Cdd:cd17371 372 AAVYYIAGLVLALLLPE 388
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-364 |
7.08e-22 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 95.81 E-value: 7.08e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 2 RKLIIGSFLGNSLEWYDFFLYGTAAALVFGSLFfpvqddplISTLLAFSGFAVGFIARPLGGILFGHIGDKYSRKTTLII 81
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLG--------ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 82 TLTLMGASTFLIGLLPTWHQvgvlapiaLISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSA- 160
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWL--------LLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPl 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 161 LAFWLVQLlpenafmtWGWRIPFLMSVFIFLVG-IYIRKNIRENKEFTQLKQASdtepeanvPVIEIFKKypKQLLQAIG 239
Cdd:COG2814 153 LGGLLADL--------FGWRWVFLVNAVLALLAlLLLLRLLPESRPAARARLRG--------SLRELLRR--PRLLLLLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 240 LRLPENGAVYIFFTFSVVFCKHVGIASDKIIAVVTLAMML-EIFSILFWGWLSDRIGRKTIYyigVIGLLLTAFPFFSLL 318
Cdd:COG2814 215 LAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLgGVLGALLAGRLADRFGRRRLL---LIGLLLLALGLLLLA 291
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 738157309 319 ASGNFsLMMLAMMLGLPLCHGAMIAAQPCIMSELFPVEVRYTGLAL 364
Cdd:COG2814 292 LAGSL-WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGL 336
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
2-417 |
2.29e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 94.55 E-value: 2.29e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 2 RKLIIGSFLGNSLEWYDFFLYGTAAALVFGSLFfpvqddplISTLLAFSGFAVGFIARPLGGILFGHIGDKYSRKTTLII 81
Cdd:COG2271 9 WRILALLFLAYFLNYLDRSNLSVAAPPLQADLG--------LSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 82 TLTLMGASTFLIGLLPTWHQvgvlapiaLISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSAL 161
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQ--------LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPP 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 162 AFWLVqllpenaFMTWGWRIPFLMSVFIFLVGIYIrknirenkeftqlkqasdtepeanvpvieifkkypkQLLQAIGLR 241
Cdd:COG2271 153 LLGWL-------LAAFGWRAAFLILGLPGLLLALL------------------------------------RFWLLALAY 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 242 LPENGAVYIFFTFSVVFCKHV-GIASDKIIAVVTLAMMLEIFSILFWGWLSDRIGRKTIYYIGVIGLLLTAFPFFSLLAS 320
Cdd:COG2271 190 FLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLP 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 321 GNFslMMLAMMLGLPLCHGAMIAAQPCIMSELFPVEVRYTGLALGHEIGaVISGGISPMIAVALLLKYDHWWPISVMLLG 400
Cdd:COG2271 270 SPA--LAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFG-FLGGALGPLLVGYLLDATGYQAAFLLLAAL 346
|
410
....*....|....*..
gi 738157309 401 FALVALIALLSIKVSPR 417
Cdd:COG2271 347 ALLAALLALLLLRETRK 363
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
10-365 |
3.77e-18 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 86.17 E-value: 3.77e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 10 LGNSLEWYDFFLYGTAAALVFGSLFFP----VQDDPLISTLLAFSgFAVGFIARPLGGILFGHIGDKYSRKTTLIITLTL 85
Cdd:pfam00083 7 LGGFLFGYDTGVIGAFLTLIDFFKNFGlsksVSSLAALSVLSGLI-VSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 86 MGASTFLIGLLPtwhqvGVLAPIALISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSALAFWL 165
Cdd:pfam00083 86 FVIGAVLQGAAK-----GKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 166 VQllpeNAFMTWGWRIPFLMSVFIFLVGIYIRKNIRENKEFTQLK----------QASDTEPEANVPVIEIF-------- 227
Cdd:pfam00083 161 LN----KTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKgrleearevlAKLRGVPDVDRELDEIKdsleagqe 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 228 --KKYPKQLLQAIGLRLP-ENGAVYIFFT----------FSVVFCKHVGIASDKIIAVVTlaMMLEIFSILFWGWLSDRI 294
Cdd:pfam00083 237 aeKASWKELFSTKTRRQRlLIGVMLQIFQqltginaifyYSTTIFENLGLSDSFLVTIIV--GVVNFVFTFIAIFLVDRF 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 738157309 295 GRKTIYYIGVIGLLLTAFPFFSLLASGNFSLMMLAMMLGLPLChgAMIAA--------QPCIMSELFPVEVRYTGLALG 365
Cdd:pfam00083 315 GRRPLLLLGAAGMAICFVILGIVALLGVSKSDWAGIVAIVFIA--LFIAFfamgwgpvPWVIVSELFPLSVRSKAMALA 391
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
41-412 |
1.25e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 80.70 E-value: 1.25e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 41 PLISTLLAFSGFAVGFI------ARPLGGILFGHIGDKYSRKTTLIITLTLMGASTFLIGLLPTWHQvgvlapiaLISLR 114
Cdd:cd17325 20 PLYAESLGASVAQIGLIvaayalAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ--------LLLAR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 115 FLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSALafwLVQLLpenaFMTWGWRIPFL-MSVFIFLVG 193
Cdd:cd17325 92 FLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPL---LGGLL----ADALGYRAPFLvCAALALLAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 194 IYIRKNIRENKEftqlKQASDTEPEANVPVIEIFKKYPKQLLQAIGLRLPENGAVYIFFTFSVVFCKHVGIASDKIIAVV 273
Cdd:cd17325 165 VLALLLLPEPRP----PPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 274 TLAMML-EIFSILFWGWLSDRIGRKTiyyIGVIGLLLTAFPFFSLLASGNFsLMMLAMMLGLPLCHGAMIAAQPCIMSEL 352
Cdd:cd17325 241 FGAQGLaSALSQPPAGKLSDRIGRKP---LILIGLLLSAVALLLLPLATSF-WLLLLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 353 FPVEVRYTGLALGHEIGAvISGGISPMIAVALllkYDHWWPISVMLLGFALVALIALLSI 412
Cdd:cd17325 317 VPPEGRGTAMGLFNTAFS-LGMVLGPLLGGFL---YDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
19-364 |
3.80e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 79.00 E-value: 3.80e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 19 FFLYGTAAALVFGSLFFPVQDDPLISTLLAFSGFAVGFIARPLGGILFGHIGDKYSRKTTLIITLTLMGASTFLIGLLPT 98
Cdd:pfam07690 5 AFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 99 WhqvgvlapIALISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSALAF-WLVQLlpenafmtW 177
Cdd:pfam07690 85 L--------WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGgLLASL--------F 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 178 GWRIPFLMSVFIFLVGIYIRKNIRENKEFTQLKQASDTEPEANVPVIEIFKKYPKQLLQAIglrLPENGAVYIFFTFSVV 257
Cdd:pfam07690 149 GWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL---LLFGFAFFGLLTYLPL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 258 FCKHVGIASDKIIAVVTLAMMLEIFSILFWGWLSDRIGRKTIYYIGVIGLLLTAFPFFsLLASGNFSLMMLAMMLGLPLC 337
Cdd:pfam07690 226 YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLL-LLSLTLSSLWLLLALLLLGFG 304
|
330 340
....*....|....*....|....*..
gi 738157309 338 HGAMIAAQPCIMSELFPVEVRYTGLAL 364
Cdd:pfam07690 305 FGLVFPALNALVSDLAPKEERGTASGL 331
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
2-412 |
6.25e-15 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 76.12 E-value: 6.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 2 RKLIIGSFLGNSLEWYDFFLYGTAAALVFGSLFFPVQDDPLISTllafsgfaVGFIARPLGGILFGHIGDKYSRKTTLII 81
Cdd:PRK12307 17 KNALFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLAT--------AAFIGRPFGGALFGLLADKFGRKPLMMW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 82 TLTLMGASTFLIGLlptwhqvgVLAPIALISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSAl 161
Cdd:PRK12307 89 SIVAYSVGTGLSGL--------ASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAA- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 162 afwlvQLLPENAfMTWGWRIPFLMSVFIFLVGIYIRKNIRENKEFTQLK------QASDTEPEANVPVIEIFKKYPKQLL 235
Cdd:PRK12307 160 -----YFMPSFA-EAYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKlsgkgkHSQSAWSVFSLSMKGLFNRAQFPLT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 236 QAIGLRL-PENGAVYIFFTFSVVFCKHVGIASDKIIAVVTLAMMLEIFSILFWGWLSDRIGRKTIYYIGVIGLLLTAFPF 314
Cdd:PRK12307 234 LCVFIVLfSIFGANWPIFGLLPTYLAGEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 315 FSLlaSGNFSLMMLAMMLGLPLCHGAMIAAQPCIMSELFPVEVRYTGLALGHEIGAViSGGISPMIAVALLLKYDHWWPI 394
Cdd:PRK12307 314 FRI--PQDNYLLLGACLFGLMATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAAT-SGTFNSMAATWLGITMGLGAAL 390
|
410
....*....|....*....
gi 738157309 395 SVMLLGF-ALVALIALLSI 412
Cdd:PRK12307 391 TFIVAFWtATILLIIGLSI 409
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
2-410 |
6.26e-13 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 70.11 E-value: 6.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 2 RKLIIGSFLGNSLEWYDFFLygtaAALVFGSlffpVQDDPLISTLLAFSGFAVGFIARPLGGILFGHIGDKYSRKTTLII 81
Cdd:PRK03893 19 WKAFSAAWLGYLLDGFDFVL----ITLVLTE----VQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 82 TLTLMGASTFLIGLLPTWhqvgvlapIALISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSAL 161
Cdd:PRK03893 91 SIVLFSVGTLACGFAPGY--------WTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQ 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 162 AFWLVQLLpenafmtWGWRIPFLMSVFIFLVGIYIRKNIRENKEFTQLKQASDTEPEAnvpVIEIFKKYPKQLlqAIGLR 241
Cdd:PRK03893 163 VYSLVVPV-------WGWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGKAPVRTM---VDILYRGEHRII--NILLT 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 242 LPENGAVYIFFTFSV----------VFCKHVGIA----SDKIIAVVTLAMMLEIFS------------------------ 283
Cdd:PRK03893 231 LAAAAALWFCFAGNLqnaaivavlgLLCAAIFISfmvqSSGKRWPTGVMLMVVVLFaflyswpiqallptylktdlgydp 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 284 -----ILFW------------GWLSDRIGRKTIYyigVIGLLLTAFPFFSLLASGNFSLMMLAMMLGLPLCHGAMIAA-Q 345
Cdd:PRK03893 311 htvanVLFFsgfgaavgccvgGFLGDWLGTRKAY---VCSLLISQLLIIPVFAIGGANVWVLGLLLFFQQMLGQGISGlL 387
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 738157309 346 PCIMSELFPVEVRYTGLALGHEIGAvISGGISPMIAVALLLKYDHWWpiSVMLLGFALVALIALL 410
Cdd:PRK03893 388 PKLIGGYFDTEQRAAGLGFTYNVGA-LGGALAPILGALIAQRLDLGT--ALASLSFSLTFVVILL 449
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
47-410 |
2.03e-12 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 67.96 E-value: 2.03e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 47 LAFSGFAVGFIarpLGGILFGHIGDKYSRKTTLIITLTLMGASTFLIGLLPTWhqvgvlapIALISLRFLQGVASGGEWG 126
Cdd:cd17324 38 LLVSAYALGYA---LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF--------ALLLLARALAGLAHGGFWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 127 GGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSA-LAFWLVQLlpenafmtWGWRIPFL-MSVFIFLVGIYIRKNIRENK 204
Cdd:cd17324 107 IAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRpLGGLLGQL--------LGWRAAFLaIAVLALLAALLLWRLLPSLP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 205 EFTqlkqasDTEPEANVPVIEIFKKypKQLLQAIGLRLPENGAVYIFFTFSVVFCKHV-GIASDKIIAVVTLAMMLEIFS 283
Cdd:cd17324 179 PKK------PGSLGLLSSLLLLLRN--PRLRLAYLITFLLFGGFFALYTYLAPFLTDVpGFSSSAIIGLLLLFGVAGVVG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 284 ILFWGWLSDRIGRKTIYY----IGVIGLLLTAFPFFSLLASGNFslmmlammlglPLCHGAMIAAQPCIMSELFPVEVRY 359
Cdd:cd17324 251 SPLAGRLADRGGRRALLIalllLAAALLLLTLLGPSPLLLLVGL-----------VLWGLGFFAAHSALQTRVLRLAPEA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 738157309 360 TGLALGHEIGAV-ISGGISPMIAvALLLKYDHWWPISVMLLGFALVALIALL 410
Cdd:cd17324 320 RGLASSLYLAAYnLGGALGAALG-GLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
3-385 |
1.55e-11 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 65.46 E-value: 1.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 3 KLIIGSFLGNSLEWYDFFLYGTAAALVFGSLFF-PVQDDPLIStllafsgfaVGFIARPLGGILFGHIGDKYSRKTTLII 81
Cdd:TIGR00895 17 RAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLdPVQLGFLFS---------AGLIGMAFGALFFGPLADRIGRRRVLLW 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 82 TLTLMGASTFLIGLLPTWHQvgvlapiaLISLRFLQGVASGGEWGGGVLMLSENAPEEKK----GYYTAWSQVGVSGGFV 157
Cdd:TIGR00895 88 SILLFSVFTLLCALATNVTQ--------LLILRFLAGLGLGGLMPNLNALVSEYAPKRFRgtavGLMFCGYPIGAAVGGF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 158 LSAlafWLVQLLpenafmtwGWRIPFLM-SVFIFLVGIYIRKNIRENKEFTQLKQ------------------------- 211
Cdd:TIGR00895 160 LAG---WLIPVF--------GWRSLFYVgGIAPLLLLLLLMRFLPESIDFLVSKRpetvrrivnaiapqmqaeaqsalpe 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 212 ASDTEPEANVPVIEIFK-KYPKQLLQAIGLRLPENGAVYIFFTFSVVFCKHVGIASDKIIAVVTLAMMLEIFSILFWGWL 290
Cdd:TIGR00895 229 QKSTQGTKRSVFKALFQgKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 291 SDRIGRKTIyyigvIGLLLTAFPFFSLLASGNFSLMMLAMMLGLP-LCHGAMIAAQPCIMSELFPVEVRYTGLALGHEIG 369
Cdd:TIGR00895 309 ADRLGPRVT-----ALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAgFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIG 383
|
410
....*....|....*.
gi 738157309 370 AVISgGISPMIAVALL 385
Cdd:TIGR00895 384 RLGA-IIGPILAGYLL 398
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
42-315 |
1.76e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 59.53 E-value: 1.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 42 LISTLLAFSGFaVGFIARPLGGILFGHIGDKY-SRKTTLIITLTLMGASTFLIGLLPTWHQVG--VLAPIALISLRFLQG 118
Cdd:COG2211 47 LVGLILLVARL-WDAITDPLIGALSDRTRTRWgRRRPWILIGAIPLALSFVLLFTAPDLSPTGklIYALVTYLLLGLAYT 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 119 VASGGEWGGGVLMLSEnaPEEKKGYYTAWSQVGVSGGFVLSALAFWLVQLLPENAfmTWGWRIPFLMSVFIFLVGIYI-R 197
Cdd:COG2211 126 LVNIPYSALGAELTPD--YEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA--ALGYRLTALIFAVLGLLAFLLtF 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 198 KNIRENKeftqlkqasdTEPEANVPVIEIFK--KYPKQLLQAIGLRLPENGAVYIFFTFSVVFCKHVGIASDKIIAVVTL 275
Cdd:COG2211 202 FGTKERP----------VPEEEKVSLKESLKalLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLA 271
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 738157309 276 AMML-EIFSILFWGWLSDRIGRKTIYYIGVIGLLLTAFPFF 315
Cdd:COG2211 272 LYFLaALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF 312
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
26-410 |
4.09e-08 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 54.74 E-value: 4.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 26 AALVFGSLFFPVQDDPLISTLLAFSGFAVGFIARPLGGILFGHIGDKYSRKTTLIITLTLMGASTFLIGLLPTWhqvgvl 105
Cdd:cd06174 11 ARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF------ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 106 apIALISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSALAFWLVQLlpenaFMTWGWRIPFLM 185
Cdd:cd06174 85 --WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS-----SLGFGWRAVFLI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 186 SVFIFLVGIYIRKNIRENKEFTQLKQASDTEPEANVPVIEIFKKYPKQLLQAIGLRLPENGAVYIFFTFSVVFCKHVGIA 265
Cdd:cd06174 158 AAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 266 SDKIIAVVTLAMMLEIFSILFWGWLSDR-IGRKTIYYIGVIGLLLtafpFFSLLASGNFSLMMLAMMLGLPLCHGAMIAA 344
Cdd:cd06174 238 VAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMAL----GLALLLLAPSLLLLLLLLLLLGFGLGGLLPL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738157309 345 QPCIMSELFPVEVRYTGLALGHEIGAvISGGISPMIAVALLLKYDHWWPISVMLLGFALVALIALL 410
Cdd:cd06174 314 SFALIAELFPPEIRGTAFGLLNTFGF-LGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
47-410 |
9.00e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 53.73 E-value: 9.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 47 LAFSGFAVGFIarpLGGILFGHIGDKYSRKTTLIITLTLMGASTFLIGLLPTWHQvgvlapiaLISLRFLQGVASGGEWG 126
Cdd:cd17319 42 LIASAFFLGYA---LFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTS--------LYVLRFLLGVAEAGFFP 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 127 GGVLMLSENAPEEKKGYYTAWSQVGVS-GGFVLSALAFWLVQLlpenafmtWGWRIPFlmsVFIFLVGIyirknirenke 205
Cdd:cd17319 111 GAIKALAEWFPARERGRATGLFNSGAPlGAAIGPPLSGWLLLL--------FGWRWAF---IIEGLLGL----------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 206 ftqlkqasdtepeanVPVIEIFKKYPKQLLQAIGlRLPENGAVYIFFTFSVVFCKHVGIASDKIIAVVT-LAMMLEIFSI 284
Cdd:cd17319 169 ---------------LLAVLWWFYLRQVWGLALG-YFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAaIPFLAGAIGM 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 285 LFWGWLSDRIGRKTIYYIGVIGLLLTAFPFFSLLASGNfSLMMLAMMLGLPLCHGAMIAAQPCIMSELFPVEVRYTGLAL 364
Cdd:cd17319 233 ILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTS-PVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGL 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 738157309 365 GHEIGAvISGGISPMIAVALLLKYDHWWPISVMLLGFALVALIALL 410
Cdd:cd17319 312 INSGGN-LGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVL 356
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
47-412 |
8.05e-07 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 50.66 E-value: 8.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 47 LAFSGFAVGFIarpLGGILFGHIGDKYSRKTTLIITLTLMGASTFLIGLLPTWhqvgvlaPIALIsLRFLQGVASGGEWG 126
Cdd:cd17317 29 LVQTIFFLGVL---IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSY-------ELFLV-LRFLVGVTSAGIFT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 127 GGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSALAFWLVQllpenafmTWGWR-----IPFLMSVFIFLVGiyirknir 201
Cdd:cd17317 98 VGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIR--------DWRWLqlaisLPGLLFLLLLWWL-------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 202 enkeftqlkqasdtepeanvpvieifkkyPKQLLQAIglrlpengavYIFFTFSVVFCKHV----GIASDKIIAVVTLAM 277
Cdd:cd17317 162 -----------------------------PRRTIIVG----------LIWFVTSLVYYGLSlnssNLGGNLYLNFFLSGL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 278 MlEIFSILFWGWLSDRIGRKTIY----YIGVIGLLLTAFpffsllASGNFSLMMLAMMLGLPLCHGAMIAAQPCIMSELF 353
Cdd:cd17317 203 V-EIPAYFLALLLLDRLGRRWTLsgslLLAGLACLVTAL------LPDDENTLALTLALVGKFAISAAFSVIYLYTAELY 275
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 738157309 354 PVEVRYTGLALGHEIGAViSGGISPMIavALLLKYDHWWPISVmllgFALVALIALLSI 412
Cdd:cd17317 276 PTVVRNTGVGLCSTVARV-GAILAPFI--VLLGKIGPLLPLII----FGVLALLGGLLT 327
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
62-200 |
1.14e-06 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 50.35 E-value: 1.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 62 GGILFGHIGDKYSRKTTLIITLTLMGASTFLIGLLPTWHQVGVLApiALISLRFLQGVASGGEWGGGVLMLSENAPEEKK 141
Cdd:cd17364 55 GQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLGVMG--WLIFFRFLLGIGIGGDYPLSATIMSEYANKKRR 132
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738157309 142 GYYTAWSQVGVSGGFVLSALAFWLVQLLPENAFMTW-------GWRIPFLMSVFIFLVGIYIRKNI 200
Cdd:cd17364 133 GALIAAVFAMQGFGILAGAIVTLILSAIFEHPLPAGtyhhadlVWRIVLGLGAIPALSVLYFRKHL 198
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
47-192 |
1.65e-06 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 50.01 E-value: 1.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 47 LAFSGFAVGFIarpLGGILFGHIGDKYSRKTTLIITLTLMGASTFLIGLLPTWhqvgvlapIALISLRFLQGVASGGEWG 126
Cdd:TIGR00898 131 LTQSCFFVGVL---LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNY--------TVFLVFRLLVGMGIGGIWV 199
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 738157309 127 GGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSALAFWLVQllpenafmtwGWRIPFL---MSVFIFLV 192
Cdd:TIGR00898 200 QAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIP----------DWRWLQLavsLPTFLFFL 258
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
52-418 |
2.02e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 49.51 E-value: 2.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 52 FAVGFIARPLGGILFGHIGDKYSRKTTLIITLTLMGASTFLIGLLPTWHQVGVLapialislRFLQGVASGGEWGGGVLM 131
Cdd:cd17365 40 GSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL--------RFLTGLGLGAAMPNAITL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 132 LSENAPEEKKGYYTAWSQVGVSGGFVLSA-LAFWLVQllpenafmTWGWRIPFLMSVFIFLVGIyirknirenkeftqlk 210
Cdd:cd17365 112 VSEYAPARRRSLAVTLMFCGYPLGAALGGfLAAALIP--------AFGWRSVFLLGGVPPLILL---------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 211 qasdtepeanvpvieifkkypkqLLQAIGLRLpenGAVYIFFTFSVVFC--------KHVGIASDKIIAVVTLAMMLEIF 282
Cdd:cd17365 168 -----------------------PLLRGTLLL---WVTFFMGLLLVYLLnswlpklmVEAGYSLSQALTITLLLNIGGVI 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 283 SILFWGWLSDRIGRKTiyyIGVIGLLLTAFPFFSLLASGNFSLMMLAMMLGLPLC-HGAMIAAQpCIMSELFPVEVRYTG 361
Cdd:cd17365 222 GSLLLGWLADRFGPKR---VLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACvNGAQVGLY-ALAARFYPTEVRATG 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 738157309 362 LALGHEIGAVisGGIS-PMIAVALLlkyDHWWPISVMLLGFALVALIALLSIKVSPRA 418
Cdd:cd17365 298 VGWALGVGRL--GAILgPLLGGLLL---AAGLGPESVFLALAIPAALGALAVLLLRLR 350
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
61-364 |
6.58e-06 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 47.95 E-value: 6.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 61 LGGILFGHIGDKYSRKTTLIITLTLMGASTFLIGLLPTWHQvgvlapiaLISLRFLQGVASGGEWGGGVLMLSENAPEEK 140
Cdd:cd17315 49 IGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWV--------LIVGRFLLGLGVGLASVLVPLYISEIAPAKI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 141 KGYYTAWSQVGVSGGFVLSALAFWLVQLLPenafmTWGWRIPFLMS---VFIFLVGIYIRknirenkeftqlkqasdteP 217
Cdd:cd17315 121 RGALGTLNQLMITFGILLAYLLGLALSLSP-----PGWWRLMFALAavpALLQLLLMFFL-------------------P 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 218 EANVPVIEIFkkypKQLLQAIglrlpeNGAVYIFFTFSVVFCKHVGIASDKIIAVVTLAMMLeiFSILFWGWLSDRIGRK 297
Cdd:cd17315 177 ESRALLVGVG----LQLLQQL------TGINAVMYYAPTIFKSAGGGTASILASIIVGVVNL--LATLVAIRLVDKVGRR 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 738157309 298 TIYYIGVIGLLLTAFP---FFSLLASGNFSLMMLAMMLGLPLCHGAMiAAQPC---IMSELFPVEVRYTGLAL 364
Cdd:cd17315 245 PLLLIGFAGMAASLLLlaiAFLLPALAKAAGWLALLGILLYIAAFAM-GAGPVpwlLLSEIFPLRIRGKGMAI 316
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
46-412 |
1.11e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 46 LLAFSGFAVGFIARPLGGILfghiGDKYSRKTTLIITLTLMGASTFLIGLLPTWHqvgvlapiALISLRFLQGVASGGEW 125
Cdd:cd17474 38 LLITAFTLPAAVLMPVAGVL----ADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA--------LLLAGRALQGIGAAGLG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 126 GGGVLMLSENAPEEKK----GYYTAWSQVGVSGGFVLSALafwlvqllpenaFMTWGWRIPFLMSVFIFLVGIYIRKNIR 201
Cdd:cd17474 106 PLALTLIGDLFEGGERakamGLYEAALGLGIAVGPLLGGL------------LAAISWRYPFFLLAALIPVAFLAILFLL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 202 ENKEftqlkqASDTEPEANVPVIEIFKKYPKQLLQAIGLRLPENGAVYIFFTFSVVFCKHVGIASDKIIAVVTLAM--ML 279
Cdd:cd17474 174 PEPK------EKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWsvLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 280 EIFSILFWGWLSDRIGRKTIYYIGVIGLLLTafpfFSLLASGNFSLMMLAMMLGLPLCHGAMIAAQPCIMSELFPVEVRY 359
Cdd:cd17474 248 ALGSLFVGRLLKKRFGARRILVIGLLLYALS----LLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERG 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 738157309 360 TGLALgHEIGAVISGGISPMIAVALLLKYDHWWPiSVMLLGFALVALIALLSI 412
Cdd:cd17474 324 TASSL-YNFVRFLGQAVGPLLFGLLLEIFGLSAP-FLVGAAIALAAAVLLALL 374
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
48-407 |
1.77e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 46.45 E-value: 1.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 48 AFSGFAVGFIARPLGGILFGHIGDKYSRKTTLIITLTLMGASTFLIGLlptwhqvGVLAPIALISLRFLQGVASGGEWGG 127
Cdd:cd17353 40 VALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAF-------AISLPLLFLGYGVLGGIGAGIGYIT 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 128 GVLMLSENAPEeKKGYYTAWsqvgVSGGFVLSAL--AFWLVQLL----PENAFMTWGwripFLMSVFIFLVGIYIR-KNI 200
Cdd:cd17353 113 PVSTAVKWFPD-KRGLATGI----VIAGFGLGSLifSPLIAYLIntvgVPTTFLILG----IIFLIIIVIGAFLIRdPPK 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 201 RENKEFTQLKQASDTEPEANVPVIEIFKKyPKQLLQAIGLRLpenGAVYIFFTFSVV--FCKHVGIASDKIIA-VVTLAM 277
Cdd:cd17353 184 GWVPPGVDPLANNAENSPRDYTPREMLRT-PTFWLLWLMFFL---NATAGLMLIGQAkpIGQEFAGLDAGIAAlAVSILS 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 278 MLEIFSILFWGWLSDRIGRKTIYYigvIGLLLTAFPFFSLLASGNFSLMMLAMMLGLPLCHGAMIAAQPCIMSELFPVE- 356
Cdd:cd17353 260 IFNGGGRPFWGWLSDKIGRKNTLS---IAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKn 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 738157309 357 --VRYTGLALGHEIGAVISGGISPMIAVALLLKYDHWWPISVMLLGFALVALI 407
Cdd:cd17353 337 agTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
20-365 |
3.56e-05 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 45.64 E-value: 3.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 20 FLYGTAAALVFGSLFFPVQDDPLISTLlafSGFAVG--FIARPLGGILFGHIGDKYSRKTTLIITLTLMGASTFLIGLLP 97
Cdd:cd17359 11 LLFGYDTGVINGALPFLQTDFNLTPFL---EGLVVSsaLLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSP 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 98 TWhqvgvlapIALISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSALAFWLVQLLPENAFMTW 177
Cdd:cd17359 88 NF--------TIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 178 -GWRIPFLMSVF---IFLVGIYIrknIRENKEFtqlkqasdtepeanvpvieIFKKYPKQLLQAIGLRLPEN--GAVYIF 251
Cdd:cd17359 160 eGWRWMLGLEAIpaiLFLLGMLF---IPESPRW-------------------LVSKGKPILIIGIGLAIFQQfvGINVIF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 252 FTFSVVFCKHVGIASDKIIAVVTLAMMLEIFSILFWgWLSDRIGRKTIYYIGVIG----LLLTAFPFFSLLASGNFSLMM 327
Cdd:cd17359 218 YYGPEIFQNAGFSENAALLQTIGIGVVNVIFTIIAI-LLVDKVGRKPLLLIGSIGmaisLLLIGTAFYFAPGSQASGIVA 296
|
330 340 350
....*....|....*....|....*....|....*....
gi 738157309 328 LAMMLGLPLCHGAMIAAQPCIM-SELFPVEVRytGLALG 365
Cdd:cd17359 297 LVLILLFVAFFAMSWGPVTWVLlSEIFPNRIR--GLAMG 333
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
50-414 |
3.64e-05 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 45.72 E-value: 3.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 50 SGFAVGFIarpLGGILFGHIGDKYSRKTTLIITLTLMGASTFLIGLLPTWHqvgvlAPIALISLRFLQGVASGGEWGGGV 129
Cdd:cd17357 56 SIFFIGGA---IGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAK-----SPELLIFGRFLVGIACGLSTGFVP 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 130 LMLSENAPEEKKGYYTAWSQVGVSGGFVLSALaFWLVQLLPENAFMTWGWRIPFLMSVFIFLVGI--------------- 194
Cdd:cd17357 128 MYLQEISPSELRGALGSLTQIGVTLGILLGQV-FGLPSVLGTETLWPYLLFFPGIPALLQLAALPffpespkflliskgd 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 195 ----------YIRKNIRENKEFTQLKQAS-DTEPEANVPVIEIFKK--YPKQLLQAIGLRLPEN--GAVYIFFtFSVVFC 259
Cdd:cd17357 207 eeeaekslkfLRGIEDDVDQELEEIKKESeQMGDQKQVSLMQLLRDpsLRLPLLLVLVVSASQQfsGINAIFF-YSTFIF 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 260 KHVGIASDKIIAVVTLAMMLEIFSILFWGWLSDRIGRKTIYYIGVIGLLLTAFPFFSLLASGNFSLMMLAMMLGLPLCHG 339
Cdd:cd17357 286 ENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFLSEQNSWMSYGCIVAIFLFI 365
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 340 AMIAAQP-----CIMSELFPVEVRYTGLALG---HEIGAVISGGISPMIAVAlllkydhwWPISVMLLgFALVALIALLS 411
Cdd:cd17357 366 FFFAIGLgpipwFIGAELFPQAPRSAAQSLGssvNWTSNFIVGMAFPPLQSI--------GGGFVFII-FAIPCALFLLY 436
|
...
gi 738157309 412 IKV 414
Cdd:cd17357 437 LYR 439
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
41-412 |
4.09e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 45.24 E-value: 4.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 41 PLISTLLAFSGFAVGFIARPLGGI------LFGHIGDKYSRKTTLIITLTLMGASTFLIGLLPTWHQVGVLAPIAlislr 114
Cdd:cd17478 20 PLLIAKLGLSYAQAGLLVSVFSITssllqpLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA----- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 115 flqGVASGGEWGGGVLMLSENAPEeKKGYYTAWSQVGVSGGFVLSALAFWLVQLLPENAFMTWGWRIPFLMSVFIFLVgi 194
Cdd:cd17478 95 ---GIGSAAFHPEGARLASQAAGG-RRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLR-- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 195 YIRKNIRENKEFTQLKQASDTEPEANVPVIeifkkypkQLLQAIGLRlpeNGAVYIFFTFSVVFCKHVGIASDKIIAVVT 274
Cdd:cd17478 169 LRPLKKPEAKKAAAKSSARSTLKGVWRALL--------LLLIIVFLR---SWVLSSLTTFLPFYLVQRGYSLVFAGLLLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 275 LAMMLEIFSILFWGWLSDRIGRKTIYYIGVIGLLLTAFPFfsLLASGNFSLMMLAMM-LGLPLCHGAMIAaqpcIMSELF 353
Cdd:cd17478 238 LFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLF--LLTPGIWSYILLVLAgFLLFASFPVTVV----LAQELL 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 354 PvevRYTGLALGHEIG-AVISGGISPMIAVALLlkyDHWWPISVMLLGFALVALIALLSI 412
Cdd:cd17478 312 P---GNVGLASGLMMGlSFGLGGIGAPVLGALA---DAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
137-322 |
1.03e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 44.13 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 137 PEEKKGYYTAWSQVGVSGGFVLSALAFWLVQLLPeNAFMTWGWRIPFLMSVFIFLVGIYIR-KNIRENKEFTQlkqasdt 215
Cdd:cd17332 131 PEERTSLTSWRMFFATIGGLLVTVLPPPLVAYFG-GGNASRGYFLTALIIGIIGIILLLICfFGTRERVVPPE------- 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 216 EPEANVPVIEIFK--KYPKQLLQAIGLRLPENGAVYIFFTFSVVFCKHVGIASDKIIAVVTLAMMLEIFSILFWGWLSDR 293
Cdd:cd17332 203 EEKSKLPLLKSLKalLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKR 282
|
170 180
....*....|....*....|....*....
gi 738157309 294 IGRKTIYYIGvIGLLLTAFPFFSLLASGN 322
Cdd:cd17332 283 FGKKKAFFIG-LLLAILGLLLLFFLPPGN 310
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
35-317 |
2.18e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 43.22 E-value: 2.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 35 FPVQDDPLISTLLAFSGFAVGFIARPLGGIlfghiGDKYSRKTTLIITLTLMGA-STFLIGLLptwhqvgvlAPIALISL 113
Cdd:COG2270 46 DPAAATALWGYALAIAGLLVALLAPVLGAI-----ADRSGRKKPFLAFFTLLGVlATAALFFV---------APGGLWLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 114 RFLQGVASGGEWGGGVL---MLSENAPEEKKGyytAWSQVGVS----GGFVLSALAFWLVQLLPENAFMTWGW--RIPFL 184
Cdd:COG2270 112 LLLFVLANIGFEGSLVFynaFLPDIATPEEIG---RVSGLGWAlgylGGVLLLLINLALFLKPEAFGLPDAGEavRISFL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 185 MS-VFIFLVGIYIRKNIRENKeftqlkqasdtePEANVPVIEIFKKYPKQLLQAIGlRLPENGAVYIF------------ 251
Cdd:COG2270 189 LTaLWWLLFALPLFLFLPERP------------RPGPAPPRGAVRAGFRELRRTLR-ELRRYRDLLRFllayffyrdgvq 255
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 738157309 252 --FTFSVVF-CKHVGIASDKIIAVVTLAMMLEIFSILFWGWLSDRIGRKTIYYIGVIGLLLTAFPFFSL 317
Cdd:COG2270 256 tvIAFAGIYaAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFL 324
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
44-194 |
2.95e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.55 E-value: 2.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 44 STLLAFSGFAVgfiarplggiLFGHIGDKYSRKTTLIITLTLMGASTFLIGLLPTwhqvgvlaPIALISLRFLQGVASGG 123
Cdd:cd17321 39 AYLLAFAALLL----------LAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGIGAAA 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 738157309 124 EWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVL-SALAFWLVQLLpenafmtwGWRIPFLMSVFIFLVGI 194
Cdd:cd17321 101 IMPASLALIAATFPGERRGRALGLWGAVVGIGAALgPLLGGLLLELF--------GWRWIFLINVPIGLVAL 164
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
46-410 |
3.63e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.58 E-value: 3.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 46 LLAFSGFAVGFIARPLGGILfghiGDKYSRKTTLIITLTLMGASTFLIGLLPTWhqvgvlapIALISLRFLQGVASGGEW 125
Cdd:cd17489 35 LVVGLFTLAALLARPFAGRL----LDRFGRKRLLLIGLLIFALATLLYLLATSV--------ALLLVLRLIHGIGWGAFT 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 126 GGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVL-SALAFWLVQLLPENAFMTWGWRIPFLMSVFIFLVGIYIRKNIRENK 204
Cdd:cd17489 103 TAAATLVADIIPPSRRGEGIGYYGLATTLAMALgPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 205 EFTQLKQASDtEPEANVPVIEIFkkypkqlLQAIGLrlpenGAVyifFTFSVVFCKHVGIASDKIIAVVTLAMMLeiFSI 284
Cdd:cd17489 183 AGTRAFRRLV-EKKVLPPALILF-------LASIAY-----GAI---STFLPLYAAERGISNAGLFFTVYAIALL--LSR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 285 LFWGWLSDRIGRKTIYYigvIGLLLTAFPFFSLLASGNFSLMMLAMMLGLPLChGAMIAAQPCIMSELFPVEVR------ 358
Cdd:cd17489 245 PFSGKLSDRKGPKTVII---PGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGF-GLLFPALQALAVDLVPPHRRgaangt 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 738157309 359 -YTGLALGHEIGAVISGGISpmiavalllkydHWWPISVMLLGFALVALIALL 410
Cdd:cd17489 321 fFIFFDLGIGLGGLLLGLVA------------ELFGYRAMFLLAAVVVLLALV 361
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
224-323 |
3.94e-04 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 42.49 E-value: 3.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 224 IEIFKKYPKQLLQAIgLRLPENGAVYIFFTF-SVVFCKHVGIASDKIIAVVTLAMMLEIFSILFWGWLSDRIG-RKTIYY 301
Cdd:cd17337 201 ITILFRNPKIAIGGI-VRIINTLSQFGFPVFmPLYFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGwRRTVRW 279
|
90 100
....*....|....*....|....
gi 738157309 302 IGVIGLLLT--AFPFFSLLASGNF 323
Cdd:cd17337 280 FGGVGCAIStlLFYYVPQLFGHNY 303
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
41-410 |
4.97e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.15 E-value: 4.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 41 PLISTLLAFSGFAVGFIA----------RPLGGILFGHIGdkySRKTTLIITLTLMGASTFLIGLLPTWHQVGVLapial 110
Cdd:cd17370 23 PLFLVVLGASAAAVGLIEglaealgsllRLFSGYLSDRTG---KRKPLVILGYGLSALAKPLLALAGSWQLVLLL----- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 111 islRFLqgvasgGEWGGGVL------MLSENAPEEKKGYYTAWSQ-VGVSGGFVLSALAFWLVQLLPENAfmtwgwRIPF 183
Cdd:cd17370 95 ---RIL------ERLGKGIRtpprdaLLADATPPSGRGKAFGLHRaLDTLGAVLGPLLAALLLYLLGGNY------RTIF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 184 LMSVFIFLVGIYIRKNIRENKEFTQLKQASDTEPEanvpvieiFKKYPKQLLQAIGLrLPENGAVYIFFTFSVVFCKHVG 263
Cdd:cd17370 160 LLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTS--------LKKLPKAFWLYLLA-VALFALGNFSFAFLILRAQELG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 264 IASDKIIAVVTLAMMLEIFSILFWGWLSDRIGRKTIYYIGVIGLLLTAFpffsLLASGNFSLMMLAMMLGLPLCHGAMIA 343
Cdd:cd17370 231 LSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYL----GFALGSSLWLLLLGFILWGLYMGAQES 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 344 AQPCIMSELFPVEVRYTGLALGHeigavISGGISPMIAVALL-LKYDHWWPISVMLLG--FALVALIALL 410
Cdd:cd17370 307 IERAAVADLVPAELRGTAYGLFN-----TVVGIGWLLASLIAgYLWDLISPSAAFLFSavLALIALLLLL 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
19-159 |
5.68e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.88 E-value: 5.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 19 FFLYGTAAALVFGSLFFPVQDDPLISTLLAFSGFAVGFIARPLGGILFGHIGDKYSRKTTLIITLTLMGASTFLIGLLPT 98
Cdd:COG2814 216 AFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS 295
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 738157309 99 whqvgvlaPIALISLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLS 159
Cdd:COG2814 296 --------LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
50-182 |
7.12e-04 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 41.57 E-value: 7.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 50 SGFAVGFIarpLGGILFGHIGDKYSRKTTLIITLTLMGASTFLIGLLPTWhqvgvlapIALISLRFLQGVASGGEWGGGV 129
Cdd:cd17379 40 SSLNLGFL---IGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNY--------PWFLIFRFLQGLFGKGGWMTGY 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 738157309 130 LMLSENAPEEKKGYYTAWSQVGVSGGFV-LSALAFWL-----VQL---LPENAFMTWGWRIP 182
Cdd:cd17379 109 VLVTEFVGSKYRRTVGIVYQMFFTLGLLiLPGIAYFIphwrwLQLavtLPNFLFLLYYWFIP 170
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
61-322 |
8.23e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.40 E-value: 8.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 61 LGGILFGHIGDKYSRKTTLIITLTLMGASTFLIGLLPTwhqvgvlaPIALISLRFLQGVASGGEWGGGVLMLSENAPEEK 140
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDS--------LYALLASRALLGIGVAGIMTLATALIGDYFEGEE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 141 KGYYTAWSQVGVS-GGFVLSALAFWLVQLlpenafmtwGWRIPFLMSVFIFLVGIYIRKNIRENKEFTQLKQASDTEPEA 219
Cdd:cd17473 122 RAKMLGLQSAAMSlGGVVFLLLGGALAEI---------GWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 220 NVPVIEIFKKYPKQLLQAIGLrlpengavYIFFTFSVVFCKHVGIASDKIIAVVTLAMMLEIFSI-LFWGWLSDRIGRKT 298
Cdd:cd17473 193 ALPWKRVLPIYFLAFLAMLLF--------YVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGaLLFGRLKRRLGKRR 264
|
250 260
....*....|....*....|....
gi 738157309 299 IYyigVIGLLLTAFPFFSLLASGN 322
Cdd:cd17473 265 LL---AIGFALMALGFLLLALASG 285
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
41-322 |
8.58e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.45 E-value: 8.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 41 PLISTLLAFSGFAVGFIARPLGG------ILFGHIGDKYSRKTTLIITLTLMGASTFLIGLlptwhqvgVLAPIALISLR 114
Cdd:cd17475 20 PFLQEDLHLSLAQVGLLLSALNLgvavsmLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL--------VGSYPVLLVLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 115 FLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSALafwlvqLLPENAfMTWGWRIPFL-MSVFIFLVG 193
Cdd:cd17475 92 FLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAA------LLPPLA-LHYGWRAAFVvAGLVSILAA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 194 IYIRKNIRENKEFTQLKQASDTEPEAnvpVIEIFKKYPKQLLQAIGLRLpeNGAVYIFFTFSVVFCK-HVGIASDKIIAV 272
Cdd:cd17475 165 VLFWLFYREPPAASAATESASTLLRS---LKEVLRNRDVWLIAIAGALL--VAPQFALLTFLLLFLHdHLGLSVVAAGAL 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 738157309 273 VTLAMMLEIFSILFWGWLSDRI--GRKTIYYIGVIGLLLTAFPFFSLLASGN 322
Cdd:cd17475 240 LAVAQLGGALGRIGLGRVSDRVfgGRRRPVLVITAAIAAAALLVLSLLSPGT 291
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
148-315 |
1.17e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 41.14 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 148 SQVGVSGGFVLSALAFWLVQLLPENAFMTWGWRIPFLMSVFIFLVGIYIRKNIreNKEFTQLKQASDTEPEANVPVIEIF 227
Cdd:pfam13347 140 SFFSVGGGLLAAALAFPLVLILGGTGLERKGYRIFALIGAVLMLLGVIITAAG--TKERVSMRSKEDTGQKEAGSLLDML 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 228 KKY--PKQLLQAIGLRLPENGAVYIFFTFSVVFCKHVGIASDKIIAVVTLAMMLEIFSILFWGWLSDRIGRKTIYYIG-V 304
Cdd:pfam13347 218 KEVfrNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGaL 297
|
170
....*....|.
gi 738157309 305 IGLLLTAFPFF 315
Cdd:pfam13347 298 ITIAGFALALL 308
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
21-315 |
1.28e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.62 E-value: 1.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 21 LYGTAAALVFGSLFFPvqddPLISTLLA---FSGFAVGFIAR--PLGGILFGHIGDKYSRKTTLIITLTLMGA-STFLIG 94
Cdd:cd17477 1 LLLSVALLGLGSGLLL----PLLSLRLEregVSTALIGLVASayYLGILLGSPLVPRLIRRVGHIRAFAAGAAiTAVSVL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 95 LLPTWHQVGVLAPialisLRFLQGVASGGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSALAFWLVQllpenaf 174
Cdd:cd17477 77 LLALTDSPWVWFL-----LRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVG------- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 175 mTWGWRIPFLMSVFIFLVGIYIrknirenkeFTQLKQASDTEPEANVPVIEIFKKYPKQLLQAIGLRLPENGavyiFFTF 254
Cdd:cd17477 145 -TAGALPFLIAAVLLLLALVPL---------LLTRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGA----FYSL 210
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 738157309 255 SVVFCKHVGIASDKIIAVVTLAMMLEIFSILFWGWLSDRIGR-KTIYYIGVIGLLLTAFPFF 315
Cdd:cd17477 211 LPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRrRVLLGCALLGALAALLLPL 272
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
16-322 |
1.54e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 40.33 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 16 WYDFFLYGTAAALVFGSLFFPVQDDPLISTLLA--FSGFAVG--FIARPLGGILFGHIGDKYSRKTTLIITLTLMGASTF 91
Cdd:cd17391 2 WLGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLVelWSGLAFSstFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 92 LIGLLPTWHQvgvlapiaLISLRFLQGVASgGEWGGGVLMLSENAPEEKKGYYTAWSQVGVSGGFVLSALafwLVQLLPE 171
Cdd:cd17391 82 LMAFVTNVWQ--------LLILRLLQGVFS-GYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPL---LGGFLAD 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 172 nafmTWGWRIPF-LMSVFIFLVGIYIRKNIREnkEFTQLkqasdtEPEANVPVIEIFK--KYPKQLLQAIGLRLPENGAV 248
Cdd:cd17391 150 ----LFGIRNVFfITGGLLFLAFLLTLFFVKE--DFKPV------EKKKMVSTKEVWNsvPNPSLLISLFVTTFIIQLAN 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 249 YIFFTFSVVFCK-------HVGIASDKIIAVVTLAMMLeifSILFWGWLSDRIGRktiYYIGVIGLLLTAFPFFSLLASG 321
Cdd:cd17391 218 QSIEPILTLYIRqlmgdasNLAFISGLVFSATGVSSLL---SAPRLGKLGDRIGH---HRILLGALLASALLYIPQAFVQ 291
|
.
gi 738157309 322 N 322
Cdd:cd17391 292 T 292
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
17-142 |
1.55e-03 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 40.87 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 17 YDFFLYgTAAALVFGSLFFPVQDDPLISTLLAFSGfaVGFIARPLGGILFGHIGDKYSRKTTLIITLTLMGASTFLIGLL 96
Cdd:TIGR00887 30 YDLFCI-SLVTKMLGYVYYHGKGPLPSSVSAAVNG--SASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLS 106
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 738157309 97 PTWHQVGVLApiALISLRFLQGVASGGEWGGGVLMLSENAPEEKKG 142
Cdd:TIGR00887 107 PGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRG 150
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
19-312 |
3.41e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.45 E-value: 3.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 19 FFLYGTAAALVfGSLFFPVQDDPLISTLLAFSGFAVGFIARPLGGILFGHIGDKYSRKTTLIITLTLMGASTFLIGLLPT 98
Cdd:COG0738 17 FFLWGFATALW-GPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 99 WhqvgvlaPIALISLrFLQGVASGGEWGGGVLMLSENAPeEKKGYYTAWSQVGVSGGFVLSALAFWLVQLLPENAfmtwG 178
Cdd:COG0738 96 Y-------PLLLLAL-FLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSL----S 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 179 WRIPFL-MSVFIFLVGIYIRKnirenKEFTQLKQASDTEPEANVPVIEIFKKypKQLLQAIGLRLPENGAVYIFFTFSVV 257
Cdd:COG0738 163 WHLPYLiLAVLLLLLALLFLR-----SKLPEIEEEEEEAAGSAASLKSLLKN--PRLLLGGLAIFLYVGAEGAIGDWLPL 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 258 FCKHV-GIASDKIIAVVTLAMMLEIFSILFWGWLSDRIGRKTIYYI----GVIGLLLTAF 312
Cdd:COG0738 236 YLKDVlGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLsallAAVGLLLALL 295
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
246-423 |
6.16e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.73 E-value: 6.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 246 GAVYIFFTFSVVFCKHVGIASDKIIAVVTLAMMLEIFSILFWGWLSDRIGRKTIYYIGVIGLLLTafPFFSLLASGNFSl 325
Cdd:cd17489 10 LSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALA--TLLYLLATSVAL- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 326 mMLAMMLGLPLCHGAMIAAQPCIMSELFPVEVRYTGLALgHEIGAVISGGISPMIAVALLLKYDHWWPISVmLLGFALVA 405
Cdd:cd17489 87 -LLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGY-YGLATTLAMALGPALGLFLYQHLGFAVLFIV-AAVLALLA 163
|
170
....*....|....*...
gi 738157309 406 LIALLSIKVSPRALSSRT 423
Cdd:cd17489 164 LLLVFLVKDPPPVAAEEA 181
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
60-197 |
6.18e-03 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 38.43 E-value: 6.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 60 PLGGILFGHIGDKYSRKTTLIITLTLMGASTFLIGLLPTWHqvgvlapiALISLRFLQGVASGGEWGGGVLMLSENAPEE 139
Cdd:cd17374 49 LVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFP--------VYCVLRFLAGFAVSGISINTLILGTEWTTPR 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 140 KKGYYTAWSQVGVS-GGFVLSALAFwlvqLLPEnafmtwgWRIPFL-MSVFIFLVGIYIR 197
Cdd:cd17374 121 HRALAITLTSCFFSiGQMLLAGLAY----AIRD-------WRLLQLvVSVPFFLFFLYSW 169
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
56-312 |
6.85e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 38.38 E-value: 6.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 56 FIARPLGGILFGHIGDKYSRKTTLIITLTLMGASTFLIGLLPtWHQVGVLAPIALIslrFLQGVASGGEWGGGVLMLSEN 135
Cdd:cd17345 48 SIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVP-SATSSVGLMFILL---FLNGWFQGMGWPPSGRTMVHW 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 136 APEEKKGYYTA-WSQVGVSGGFVLSALAFWLVqllpeNAFMTWGWRIPFLM-SVFIFLVGIYIRKNIRENKEFTQL---- 209
Cdd:cd17345 124 FSKKERGTWTSiWNISHNVGGGLVGPLAGLGL-----AIFGDGWWRGAFIFpAIIAIIVAVIVLFLGKDTPESEGLppie 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738157309 210 -------KQASDTEPEANVPVIEIFKKY--PKQLLQAIGLrlpENGAVYI----FFTFSVVFCKHV-GIASDKIIAVVTL 275
Cdd:cd17345 199 eykgdypEEADGEEEEQELSAWEIFVKYvlKNKLLWYIAI---ANVFVYLvrygILDWAPTYLSEVkGFSKAQAMWAFSL 275
|
250 260 270
....*....|....*....|....*....|....*..
gi 738157309 276 AMMLEIFSILFWGWLSDRIGRKTIYYIGVIGLLLTAF 312
Cdd:cd17345 276 FEWAAIPGTLLAGWLSDKLFKGRRAPTGIIFMILVIV 312
|
|
| |
