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Conserved domains on  [gi|738363981|ref|WP_036316244|]
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MULTISPECIES: MFS transporter [Bacteria]

Protein Classification

MFS transporter( domain architecture ID 1002999)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK14995 super family cl33053
SmvA family efflux MFS transporter;
10-461 8.96e-79

SmvA family efflux MFS transporter;


The actual alignment was detected with superfamily member PRK14995:

Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 254.27  E-value: 8.96e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  10 ITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPAFL 89
Cdd:PRK14995  18 VAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWL 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  90 IGARALLAVGAAAMMPATLALIRLAFDDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPVVAIALVA 169
Cdd:PRK14995  98 IATRALLAIGAAMIVPATLAGIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 170 TAIIAPHNHPDPSKKWDLVSSLYAMVGLVGTVLVIKELAHIPQNWVLIAGALASAVIGFVLFVRRQGRLEEPLIEFSIFR 249
Cdd:PRK14995 178 TARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFT 257
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 250 NRAFAGGSLAAFFAMFTIAGAQLATTQRFQLVEGFTPLQAGLLVAAIALGALPSGVLGAAILHIVGLRIIISGSLAIAAL 329
Cdd:PRK14995 258 HRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGGMALSAL 337
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 330 GLALAVLASANGSLPLLVVSFIVTGFGLGGTFAVASAAIMGNAPPRKAGMAASIEEVSYEMGSLSAVALLGSLLTFVYAT 409
Cdd:PRK14995 338 SFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAIFGLLLSRSYSA 417
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 738363981 410 VVRLPDGTPAA----AGESIADALGIADgDLD------VIAAATSAYDTAYLVTMIVLAVML 461
Cdd:PRK14995 418 SIRLPAGLPAQliekASSSIGEAVQLAN-SLPptlgqaLLDAAKQAFIWSHSVVLSSAGSML 478
 
Name Accession Description Interval E-value
PRK14995 PRK14995
SmvA family efflux MFS transporter;
10-461 8.96e-79

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 254.27  E-value: 8.96e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  10 ITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPAFL 89
Cdd:PRK14995  18 VAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWL 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  90 IGARALLAVGAAAMMPATLALIRLAFDDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPVVAIALVA 169
Cdd:PRK14995  98 IATRALLAIGAAMIVPATLAGIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 170 TAIIAPHNHPDPSKKWDLVSSLYAMVGLVGTVLVIKELAHIPQNWVLIAGALASAVIGFVLFVRRQGRLEEPLIEFSIFR 249
Cdd:PRK14995 178 TARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFT 257
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 250 NRAFAGGSLAAFFAMFTIAGAQLATTQRFQLVEGFTPLQAGLLVAAIALGALPSGVLGAAILHIVGLRIIISGSLAIAAL 329
Cdd:PRK14995 258 HRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGGMALSAL 337
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 330 GLALAVLASANGSLPLLVVSFIVTGFGLGGTFAVASAAIMGNAPPRKAGMAASIEEVSYEMGSLSAVALLGSLLTFVYAT 409
Cdd:PRK14995 338 SFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAIFGLLLSRSYSA 417
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 738363981 410 VVRLPDGTPAA----AGESIADALGIADgDLD------VIAAATSAYDTAYLVTMIVLAVML 461
Cdd:PRK14995 418 SIRLPAGLPAQliekASSSIGEAVQLAN-SLPptlgqaLLDAAKQAFIWSHSVVLSSAGSML 478
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
3-472 4.72e-57

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 193.54  E-value: 4.72e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   3 VGAGLLLITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAF 82
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  83 SPNPAFLIGARALLAVGAAAMMPATLALIRLAFdDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPV 162
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATF-PGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 163 VAIALVATaiiaphnhpdpskkwdlvsslyamvglvgtvlvikelahipqnwvliagalasavigfvlfvrrqgrleepl 242
Cdd:cd17321  160 GLVALLLA------------------------------------------------------------------------ 167
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 243 iefsifrnRAFAGGSLAAFFAMFTIAGAQLATTQRFQLVEGFTPLQAGLLVAAIALGALPSGVLGAAILHIVGLRIIISG 322
Cdd:cd17321  168 --------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVA 239
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 323 SLAIAALGLALAVLASANGSLPLLVVSFIVTGFGLGGTFAVASAAIMGNAPPRKAGMAASIEEVSYEMGSLSAVALLGSL 402
Cdd:cd17321  240 GLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 403 LTFVYATVVRLPDGTPAAagesiadalgiadgdldviAAATSAYDTAYLVTMIVLAVMLASGAALTNRLL 472
Cdd:cd17321  320 LTAGLSANLGDSGVAALL-------------------SAAAAAFAAGFHLAFLVAAALALLAALLALLLP 370
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
5-404 2.95e-42

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 156.77  E-value: 2.95e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981    5 AGLLLITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSP 84
Cdd:TIGR00711   9 LGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAP 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   85 NPAFLIGARALLAVGAAAMMPATLALIRLAFdDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPVVA 164
Cdd:TIGR00711  89 NLELMIIFRVIQGFGGGPLIPLSFSTLLNIY-PPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGI 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  165 IALVATAIIAPHNHPDPSKKWDLVSSLYAMVGLVGTVLVI---KELAHIPQNWVLIAGALasAVIGFVLFVRRQGRLEEP 241
Cdd:TIGR00711 168 IVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLsegPERGWFDSNEILILSIT--GLVAIIAFVVWELTDDNP 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  242 LIEFSIFRNRAFAGGSLAAFFAMFTIAGAQLATTQRFQLVEGFTPLQAGLLVAAIALGALPSGVLGAAILHIVGLRIIIS 321
Cdd:TIGR00711 246 LVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVT 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  322 GSLAIAALGLALAVLASANGSlPLLVVSF--IVTGFGLGGTFAVASAAIMGNAPPRKAGMAASIEEVSYEMGSLSAVALL 399
Cdd:TIGR00711 326 IGLILYAVGFYWRAFTFTPDT-PFLAIALpqFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALI 404

                  ....*
gi 738363981  400 GSLLT 404
Cdd:TIGR00711 405 TTILT 409
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
3-273 1.02e-25

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 106.43  E-value: 1.02e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   3 VGAGLLLITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAF 82
Cdd:COG0477   19 LALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  83 SPNPAFLIGARALLAVGAAAMMPATLALIRLAFdDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPV 162
Cdd:COG0477   99 APSPELLIAARALQGIGAGGLMPGALALIAELF-PARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 163 VAIALVATAIIAPHNHPDPSKKWDLVSSLYAMVGLVGTVLVIKELAHIPQNWVLIAGALASAVIGFVLFVRRQGRLEEPL 242
Cdd:COG0477  178 GLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALL 257
                        250       260       270
                 ....*....|....*....|....*....|.
gi 738363981 243 IEFSIFRNRAFAGGSLAAFFAMFTIAGAQLA 273
Cdd:COG0477  258 LLAALLLLLLLLLLLALLLALLLLLLLLLLL 288
MFS_1 pfam07690
Major Facilitator Superfamily;
3-383 6.66e-18

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 84.78  E-value: 6.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981    3 VGAGLLLITLDNSILYTALP-TLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAA 81
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   82 FSPNPAFLIGARALLAVGAAAMMPATLALIRLAFdDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVP 161
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWF-PPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  162 VVAIALVATAIIAPHNHPDPSKKWDLVsslyamvgLVGTVLVIKELAHIPQNWVLIagalasavigfvlfvrrqgrleep 241
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEA--------RLSLIVAWKALLRDPVLWLLL------------------------ 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  242 liefsifrnrafaggslaAFFAMFTIAGAQLATTQRFQLVEGFTPLQAGLLVAAIALGALPSGVLGAAILHIVGLRIIIS 321
Cdd:pfam07690 208 ------------------ALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL 269
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 738363981  322 GSLAIAALGLALAVLASANGSLPLLVVSFIVTGFGLGGTFAVASAAIMGNAPPRKAGMAASI 383
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGL 331
 
Name Accession Description Interval E-value
PRK14995 PRK14995
SmvA family efflux MFS transporter;
10-461 8.96e-79

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 254.27  E-value: 8.96e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  10 ITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPAFL 89
Cdd:PRK14995  18 VAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWL 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  90 IGARALLAVGAAAMMPATLALIRLAFDDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPVVAIALVA 169
Cdd:PRK14995  98 IATRALLAIGAAMIVPATLAGIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 170 TAIIAPHNHPDPSKKWDLVSSLYAMVGLVGTVLVIKELAHIPQNWVLIAGALASAVIGFVLFVRRQGRLEEPLIEFSIFR 249
Cdd:PRK14995 178 TARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFT 257
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 250 NRAFAGGSLAAFFAMFTIAGAQLATTQRFQLVEGFTPLQAGLLVAAIALGALPSGVLGAAILHIVGLRIIISGSLAIAAL 329
Cdd:PRK14995 258 HRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGGMALSAL 337
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 330 GLALAVLASANGSLPLLVVSFIVTGFGLGGTFAVASAAIMGNAPPRKAGMAASIEEVSYEMGSLSAVALLGSLLTFVYAT 409
Cdd:PRK14995 338 SFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAIFGLLLSRSYSA 417
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 738363981 410 VVRLPDGTPAA----AGESIADALGIADgDLD------VIAAATSAYDTAYLVTMIVLAVML 461
Cdd:PRK14995 418 SIRLPAGLPAQliekASSSIGEAVQLAN-SLPptlgqaLLDAAKQAFIWSHSVVLSSAGSML 478
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
3-472 4.72e-57

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 193.54  E-value: 4.72e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   3 VGAGLLLITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAF 82
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  83 SPNPAFLIGARALLAVGAAAMMPATLALIRLAFdDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPV 162
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATF-PGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 163 VAIALVATaiiaphnhpdpskkwdlvsslyamvglvgtvlvikelahipqnwvliagalasavigfvlfvrrqgrleepl 242
Cdd:cd17321  160 GLVALLLA------------------------------------------------------------------------ 167
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 243 iefsifrnRAFAGGSLAAFFAMFTIAGAQLATTQRFQLVEGFTPLQAGLLVAAIALGALPSGVLGAAILHIVGLRIIISG 322
Cdd:cd17321  168 --------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVA 239
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 323 SLAIAALGLALAVLASANGSLPLLVVSFIVTGFGLGGTFAVASAAIMGNAPPRKAGMAASIEEVSYEMGSLSAVALLGSL 402
Cdd:cd17321  240 GLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 403 LTFVYATVVRLPDGTPAAagesiadalgiadgdldviAAATSAYDTAYLVTMIVLAVMLASGAALTNRLL 472
Cdd:cd17321  320 LTAGLSANLGDSGVAALL-------------------SAAAAAFAAGFHLAFLVAAALALLAALLALLLP 370
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
5-404 2.95e-42

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 156.77  E-value: 2.95e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981    5 AGLLLITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSP 84
Cdd:TIGR00711   9 LGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAP 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   85 NPAFLIGARALLAVGAAAMMPATLALIRLAFdDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPVVA 164
Cdd:TIGR00711  89 NLELMIIFRVIQGFGGGPLIPLSFSTLLNIY-PPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGI 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  165 IALVATAIIAPHNHPDPSKKWDLVSSLYAMVGLVGTVLVI---KELAHIPQNWVLIAGALasAVIGFVLFVRRQGRLEEP 241
Cdd:TIGR00711 168 IVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLsegPERGWFDSNEILILSIT--GLVAIIAFVVWELTDDNP 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  242 LIEFSIFRNRAFAGGSLAAFFAMFTIAGAQLATTQRFQLVEGFTPLQAGLLVAAIALGALPSGVLGAAILHIVGLRIIIS 321
Cdd:TIGR00711 246 LVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVT 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  322 GSLAIAALGLALAVLASANGSlPLLVVSF--IVTGFGLGGTFAVASAAIMGNAPPRKAGMAASIEEVSYEMGSLSAVALL 399
Cdd:TIGR00711 326 IGLILYAVGFYWRAFTFTPDT-PFLAIALpqFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALI 404

                  ....*
gi 738363981  400 GSLLT 404
Cdd:TIGR00711 405 TTILT 409
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
3-433 1.48e-34

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 133.09  E-value: 1.48e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   3 VGAGLLLITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAF 82
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  83 SPNPAFLIGARALLAVGAAAMMPATLALIRLAFdDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPV 162
Cdd:cd17503   81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIY-PPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 163 VAIALVATaiiaphnhpdpskkwdlvsslyamvglvgtvlvikelahipqnwvliagalasavigfvlfvrrqgrleePL 242
Cdd:cd17503  160 GILALLLA----------------------------------------------------------------------PL 169
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 243 IEFSIFRNRAFAGGSLAAFFAMFTIAGAQLATTQRFQLVEGFTPLQAGLLVAAIALGALPSGVLGAAILHIVGLRIIISG 322
Cdd:cd17503  170 LDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLA 249
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 323 SLAIAALGLALAVLASANGSLPLLVVSFIVTGFGLGGTFAVASAAIMGNAPPRKAGMAASIEEVSYEMGSLSAVALLGSL 402
Cdd:cd17503  250 GLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATL 329
                        410       420       430
                 ....*....|....*....|....*....|.
gi 738363981 403 LTFVYATVVRLPDGTPAAAGESIADALGIAD 433
Cdd:cd17503  330 LTNRTQFHHSRLSELLAQQVQKQALIIAFND 360
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
3-273 1.02e-25

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 106.43  E-value: 1.02e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   3 VGAGLLLITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAF 82
Cdd:COG0477   19 LALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  83 SPNPAFLIGARALLAVGAAAMMPATLALIRLAFdDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPV 162
Cdd:COG0477   99 APSPELLIAARALQGIGAGGLMPGALALIAELF-PARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 163 VAIALVATAIIAPHNHPDPSKKWDLVSSLYAMVGLVGTVLVIKELAHIPQNWVLIAGALASAVIGFVLFVRRQGRLEEPL 242
Cdd:COG0477  178 GLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALL 257
                        250       260       270
                 ....*....|....*....|....*....|.
gi 738363981 243 IEFSIFRNRAFAGGSLAAFFAMFTIAGAQLA 273
Cdd:COG0477  258 LLAALLLLLLLLLLLALLLALLLLLLLLLLL 288
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
3-383 3.29e-25

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 106.21  E-value: 3.29e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   3 VGAGLLLITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAF 82
Cdd:COG2814   15 LALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  83 SPNPAFLIGARALLAVGAAAMMPATLALIRLAFdDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPV 162
Cdd:COG2814   95 APSLWLLLAARFLQGLGAGALFPAALALIADLV-PPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 163 VAIALVATAIIAPHNHPDPSKKwdlvsslyamvglvgtvlvikelahipqnwvliagalasavigfvlfvrrqgrleEPL 242
Cdd:COG2814  174 ALLALLLLLRLLPESRPAARAR-------------------------------------------------------LRG 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 243 IEFSIFRNRAFAGGSLAAFFAMFTIAGAQLATTQRFQLVEGFTPLQAGLLVAAIALGALPSGVLGAAILHIVGLRIIISG 322
Cdd:COG2814  199 SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLI 278
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 738363981 323 SLAIAALGLALAVLAsanGSLPLLVVSFIVTGFGLGGTFAVASAAIMGNAPPRKAGMAASI 383
Cdd:COG2814  279 GLLLLALGLLLLALA---GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGL 336
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
3-398 2.52e-24

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 103.41  E-value: 2.52e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   3 VGAGLLLITLDNSILYTALPTLTADLGASGSSTlWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAF 82
Cdd:cd17502    1 LMLALFLAALDQTIVATALPTIVAEFGGLSLVS-WVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  83 SPNPAFLIGARALLAVGAAAMMPATLALIRLAFdDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPV 162
Cdd:cd17502   80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLV-PPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 163 VAIALvataiiaphnhpdpskkwdlvsslyamvglvgtvlvikelahipqnwVLIAGALASAVIGFVlfvrrqgrleepl 242
Cdd:cd17502  159 GGLAL-----------------------------------------------ALLRTILLSSIFGFL------------- 178
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 243 iefsifrnrafagGSLAAFFAMFTIagaqlatTQRFQLVEGFTPLQAGLLVAAIALGALPSGVLGAAILHIVG-LRIIIS 321
Cdd:cd17502  179 -------------FGGALFGLIYYL-------PLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIV 238
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 738363981 322 GSLAIAALGLALAVLASANGSLPLLVVSFIVTGFGLGGTFAVASAAIMGNAPPRKAGMAASIEEVSYEMGSLSAVAL 398
Cdd:cd17502  239 IGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
1-420 4.14e-21

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 94.64  E-value: 4.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   1 MTVGAGLLLITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAA 80
Cdd:cd17476    1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  81 AFSPNPAFLIGARALLAVGAAAMMPATLALIRLAFDDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINv 160
Cdd:cd17476   81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFL- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 161 pvvAIALVATAIIAphnhpdpskkwdlvsslyamvglvgtvlvikelahipqnwvliagalasavigfvlfvrrqgrlee 240
Cdd:cd17476  160 ---AILAAIVAVAA------------------------------------------------------------------ 170
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 241 pliefsIFRNRAFAGGSLAAFFAMF-TIAGAQLATTQRFQLVEGFTPLQAGLLVAAIAL-GALPSGVLGAAILHIVGLRI 318
Cdd:cd17476  171 ------IFWTSPSFIAVLLAVFLGWaSFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIgGVLAAITVGFLIARLPPSYI 244
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 319 IISGSLAIAALGLALAVLASANGSLPLLVVSFIVTGFGLGGTFAVASAAIMGNAPPRKAGMAASIEEVSYEMGSLSAVAL 398
Cdd:cd17476  245 MAISMVAFLVGPILFATMPVHQTYWAQAFPAMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNYGISIGLGI 324
                        410       420
                 ....*....|....*....|..
gi 738363981 399 LGSLLTFVYATVVRLPDGTPAA 420
Cdd:cd17476  325 AGTVETSVNEDGADLLKGYRAA 346
PRK10504 PRK10504
putative transporter; Provisional
3-301 8.29e-21

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 94.80  E-value: 8.29e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   3 VGAGLLLITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAF 82
Cdd:PRK10504  15 VAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  83 SPNPAFLIGARALLAVGAAAMMP-ATLALIRLAfddPRERNIAIAIWGSL-SIAGAALGPILGGALLERFWWGSVFLINV 160
Cdd:PRK10504  95 SGTLNELLLARVLQGVGGAMMVPvGRLTVMKIV---PREQYMAAMTFVTLpGQVGPLLGPALGGLLVEYASWHWIFLINI 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 161 PVVAIALVATAIIAPhNHPDPSKKWDLVSSLYAMVGLVGTVLVIKELAHIPQNWVLIAGALASAVIGFVLFVRRQGRLEE 240
Cdd:PRK10504 172 PVGIIGAIATLMLMP-NYTMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNR 250
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 738363981 241 PLIEFSIFRNRAFAGGSLAAFFAMFTIAGAQLATTQRFQLVEGFTPLQAGLLVAAIALGAL 301
Cdd:PRK10504 251 ALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSM 311
MFS_1 pfam07690
Major Facilitator Superfamily;
3-383 6.66e-18

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 84.78  E-value: 6.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981    3 VGAGLLLITLDNSILYTALP-TLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAA 81
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   82 FSPNPAFLIGARALLAVGAAAMMPATLALIRLAFdDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVP 161
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWF-PPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  162 VVAIALVATAIIAPHNHPDPSKKWDLVsslyamvgLVGTVLVIKELAHIPQNWVLIagalasavigfvlfvrrqgrleep 241
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEA--------RLSLIVAWKALLRDPVLWLLL------------------------ 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  242 liefsifrnrafaggslaAFFAMFTIAGAQLATTQRFQLVEGFTPLQAGLLVAAIALGALPSGVLGAAILHIVGLRIIIS 321
Cdd:pfam07690 208 ------------------ALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL 269
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 738363981  322 GSLAIAALGLALAVLASANGSLPLLVVSFIVTGFGLGGTFAVASAAIMGNAPPRKAGMAASI 383
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGL 331
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
3-404 4.31e-17

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 82.63  E-value: 4.31e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   3 VGAGLLLITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAF 82
Cdd:cd17504    1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  83 SPNPAFLIGARALLAVGaAAMMPATLALIRLAFdDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPV 162
Cdd:cd17504   81 APNLPVLIAGRALQGIG-GAVFPLAFALVREEF-PPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 163 VAIALVATaiiaphnhpdpskkwdlvsslyamvglvgtvlvikelahipqnwvliagalasavigfvlfvrrqgrleePL 242
Cdd:cd17504  159 AVLLAALV----------------------------------------------------------------------PL 168
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 243 IEFSIFRNRAFAGGSLAAFFAMFTIAGAQLATTQRFQLVE----GFTPLQAGLLVAAIALGALPSGVLGAAILHIVGLRI 318
Cdd:cd17504  169 IDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTptgfGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRR 248
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 319 IISGSlaIAALGLALAVLASANGSLPLLVVSFIVTGFGLGGTFAVASAAIMGNAPPRKAGMAASIEEVSYEMGSLSAVAL 398
Cdd:cd17504  249 VLLIG--LVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAI 326

                 ....*.
gi 738363981 399 LGSLLT 404
Cdd:cd17504  327 AGAILT 332
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
3-393 1.16e-16

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 81.47  E-value: 1.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   3 VGAGLLLITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAF 82
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  83 SPNPAFLIGARALLAVGAAAMMPATLALIrLAFDDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPV 162
Cdd:cd17325   81 ATSYWQLLLARFLQGLASAAVWPAAMALI-ADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 163 VAIALVATAIIAPHNHPDPSKKwdlvsslyamvgLVGTVLVIKELAHIPQNWVLIAGALASAVIGFVLfvrrqgrleepl 242
Cdd:cd17325  160 ALLALVLALLLLPEPRPPPNKR------------AVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAF------------ 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 243 iefsifrnrafagGSLAAFFAMFtiagaqlattqrFQLVEGFTPLQAGLLVAAIALGALPSGVLGAAILHIVGLRIIISG 322
Cdd:cd17325  216 -------------GALEPFLPLY------------AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILI 270
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 738363981 323 SLAIAALGLALAVLAsanGSLPLLVVSFIVTGFGLGGTFAVASAAIMGNAPPRKAGMAASIEEVSYEMGSL 393
Cdd:cd17325  271 GLLLSAVALLLLPLA---TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMV 338
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
3-404 4.99e-16

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 79.53  E-value: 4.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   3 VGAGLLLITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAF 82
Cdd:COG2271   15 LFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  83 SPNPAFLIGARALLAVGAAAMMPATLALIRLAFdDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPV 162
Cdd:COG2271   95 ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWF-PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLP 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 163 VAIALVATaiiaphnhpdpskkwdlvsslyamvglvgtvlvikelahipqnwvliagalasavigfvlfvrrqgrleepl 242
Cdd:COG2271  174 GLLLALLR------------------------------------------------------------------------ 181
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 243 iefsifrnraFAGGSLAAFFAMFTIAGAQLATTQRFQLVEGFTPLQAGLLVAAIALGALPSGVLGAAILHIVGLRIIISG 322
Cdd:COG2271  182 ----------FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL 251
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 323 SLAIAALGLALAVLASAnGSLPLLVVSFIVTGFGLGGTFAVASAAIMGNAPPRKAGMAASIEEVSYEMGSLSAVALLGSL 402
Cdd:COG2271  252 AIGLLLAALALLLLALL-PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL 330

                 ..
gi 738363981 403 LT 404
Cdd:COG2271  331 LD 332
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
8-383 2.13e-15

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 77.61  E-value: 2.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   8 LLITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPA 87
Cdd:cd17474    9 LLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  88 FLIGARALLAVGAAAMMPATLALIrLAFDDPRERNIAIAIWGSLSIAGAALGPILGGALLErFWWGSVFLINVPVVAIAL 167
Cdd:cd17474   89 LLLAGRALQGIGAAGLGPLALTLI-GDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 168 VATAIIAPHNHPDPskkwdlvsslyamvglvgtvlvikelahipqnwvliagalasavigfvlfvrRQGRLEEPLIEFSI 247
Cdd:cd17474  167 LAILFLLPEPKEKA----------------------------------------------------KSSSATKLRDLKKA 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 248 FRNRAFAGGSLAAFFAMFTIAGAQLATTQRFQLVEGFTPLQAGLLVAAIALG-ALPSGVLGAAILHIVGLRIIISGSLAI 326
Cdd:cd17474  195 LRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLlALGSLFVGRLLKKRFGARRILVIGLLL 274
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 738363981 327 AALGLALAVLASangSLPLLVVSFIVTGFGLGGTFAVASAAIMGNAPPRKAGMAASI 383
Cdd:cd17474  275 YALSLLLLGFVP---SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSL 328
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
20-402 2.97e-12

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 67.99  E-value: 2.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  20 ALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVG 99
Cdd:cd17320   21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 100 AAAMMPATLALIRLAFDDPRERNIAIAIWGSLSIAgAALGPILGGALLERFWWGSVFlinvpvvaialvataiiaphnhp 179
Cdd:cd17320  101 AAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIA-PALAPLLGGLLLLFFGWRAIF----------------------- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 180 dpskkwdLVSSLYAMVGLVGTVLVIKELAHIPQNWVLIAGALASAvigfvlfvrrqgrleeplieFSIFRNRAFAGGSLA 259
Cdd:cd17320  157 -------VFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAY--------------------KRVLKNRRFLGYALA 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 260 AFFAMFTIAGAQLATTQRFQLVEGFTPLQAGLLVAAIALGALPSGVLGAAILHIVGLR--IIISGSLAIAALGLALAVLA 337
Cdd:cd17320  210 LGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRrlLRLGLLLLLAAALVLLLAAL 289
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 738363981 338 SANGSLPLLVVSFIVTGFGLGGTFAVASAAIMGNApPRKAGMAASIEEVSYEMGSLSAVALLGSL 402
Cdd:cd17320  290 LGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPF-PHVAGTASALLGFLQFLIGALAGALVGLL 353
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
19-450 3.08e-11

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 65.34  E-value: 3.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  19 TALPTLTADLGASGSSTlWIINAYPLVMAGLLLGAGTLGDRIGhRRMFVVGLWIFG-AASLAAAFSPNPAFLIGARALLA 97
Cdd:cd06179   19 AVLPFIVADLGPSSNST-WISTAWSLAQAVLGPIVGRLSDLFG-RRWFFIGGNLLGvVGSIVAGTAKSVNMLIGGQALIG 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  98 VGAAAMMPATLALIRLAfdDPRERNIAIAIWGSLSIAGAALGPILGGALLERFW--WGSVFLINVPVVAIALVATAIIAp 175
Cdd:cd06179   97 IGAGTQGLGAAVASELV--PNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFYINAIFNALALILLFFFY- 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 176 HNHPDPSKKWDLVSSLYAMVGLVGTVLVIKELAHI---------PQNWVlIAGALASAVIGFVLFV-----RRQGRLEEP 241
Cdd:cd06179  174 HPPPRPQLHGSSTRQKLKRLDWVGLFLLIAGLVLFllglswggnPYPWS-SAHVIAPLVIGGVLLIafglyEWKGTKDGL 252
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 242 LIEFSIFRNRAFAGGSLAAFFAMFTIAGAQLATTQRFQLVEGFTPLQAGLLVAAIALGALPSGVLGAAILHIVG-LRIII 320
Cdd:cd06179  253 LPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKhIKWQL 332
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 321 SGSLAIAALGLALAVLASANGSLPLLVVSFIvTGFGLGGTFAVASAAIMGNAPPRKAGMAASIEEVSYEMGSLSAVALLG 400
Cdd:cd06179  333 VAGFVLFTAFLALLALITPDNKALAIAFSVL-AGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARALGGAVGTAIFT 411
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738363981 401 SLLT---------FVYATVVR-------LPDGTPAAAGESIADALGIADGDLDVIAAATSAYDTAY 450
Cdd:cd06179  412 SILSnrlsknlpaRVAPAALEaglpassLPALLGALASGNIAALTAVPGINPEIIAAATAALKQAY 477
2_A_01_02 TIGR00880
Multidrug resistance protein;
58-175 7.32e-11

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 59.97  E-value: 7.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   58 DRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVGAAAMMPATLALIRLAFDdPRERNIAIAIWGSLSIAGAA 137
Cdd:TIGR00880  23 DRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP-PEERGVALGLMSAGIALGPL 101
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 738363981  138 LGPILGGALLERFWWGSVFLINVPVVAIALVATAIIAP 175
Cdd:TIGR00880 102 LGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
3-403 8.05e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 63.60  E-value: 8.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   3 VGAGLLLITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAF 82
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  83 SPNPAFLIGARALLAVGAAAMMPATLALIRLAFdDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWG--SVFLINV 160
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLF-PERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwrAVFLIAA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 161 PVVAIALVATAIIAPHNHPDPSKKWDLVSSLYAMVGLvgtvlvikelahipqnwvliagalasavigfvlfvrrqgrlee 240
Cdd:cd06174  160 ALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLL------------------------------------------- 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 241 plieFSIFRNRAFAGGSLAAFFAMFTIAGAQLATTQRFQLVEGFTPLQAGLLVAAIALGALPSGVLGAAILHIVGLRIII 320
Cdd:cd06174  197 ----KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPL 272
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 321 SGslAIAALGLALAVLASANGSLPLLVVSFIVTGFGLGGTFAVASAAIMGNAPPRKAGMAASIEEVSYEMGSLSAVALLG 400
Cdd:cd06174  273 LL--IGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAG 350

                 ...
gi 738363981 401 SLL 403
Cdd:cd06174  351 FLL 353
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
15-174 1.16e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 62.98  E-value: 1.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  15 SILYTALPTLTADLGASGSSTL-WIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGAR 93
Cdd:cd17325  216 GALEPFLPLYAAELGGLSPAQIgLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLL 295
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  94 ALLAVGAAAMMPATLALIRLAFDdPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPVVAIALVATAII 173
Cdd:cd17325  296 ALLGLGLGLVFPATLALLADIVP-PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374

                 .
gi 738363981 174 A 174
Cdd:cd17325  375 R 375
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
22-383 1.25e-10

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 62.98  E-value: 1.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  22 PTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVGAA 101
Cdd:COG2223   29 PPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGG 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 102 AMMPATLALIRLAFdDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPVVAIALVATAIIAPHNHPDP 181
Cdd:COG2223  109 GSFAVGIALVSKWF-PPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGA 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 182 SKKwdlvsslyamvglvgtvlvikelahipqnwvliagalasavigfvlfvrRQGRLEEPLiefSIFRNRAFAGGSLAAF 261
Cdd:COG2223  188 AAA-------------------------------------------------AKASLRDQL---EALRDPRFWLLSLLYF 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 262 FAMFTIAGAQLATTQRFQLVEGFTPLQAGLLVAAIALGALPSGVLGAAILHIVGLRIIISGSLAIAALGLALAVLASanG 341
Cdd:COG2223  216 GTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAL--G 293
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 738363981 342 SLPLLVVSFIVTGFGLGGTFAVASAAIMGNAPPRKAGMAASI 383
Cdd:COG2223  294 SLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGL 335
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
20-179 3.09e-10

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 62.02  E-value: 3.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   20 ALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVG 99
Cdd:TIGR00710  27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  100 AAAMMPATLALIRLAFDDpRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPVVAIALVATAIIAPHNHP 179
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPG-EELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLP 185
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
21-194 4.11e-10

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 61.41  E-value: 4.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  21 LPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVGA 100
Cdd:cd17324   22 LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAH 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 101 AAMMPATLALIRLAFdDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPVVAIALVATAIIAPHNHPD 180
Cdd:cd17324  102 GGFWAIAAAYAADLV-PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPK 180
                        170
                 ....*....|....
gi 738363981 181 PSKKWDLVSSLYAM 194
Cdd:cd17324  181 KPGSLGLLSSLLLL 194
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
12-158 1.90e-09

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 59.12  E-value: 1.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  12 LDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIG 91
Cdd:cd17319   17 LDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYV 96
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 738363981  92 ARALLAVGAAAMMPATLALIRLAFdDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLI 158
Cdd:cd17319   97 LRFLLGVAEAGFFPGAIKALAEWF-PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII 162
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
58-383 1.93e-09

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 59.12  E-value: 1.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  58 DRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVGAAAMMPATLALIRLAFDDPrERNIAIAIWGSLSIAGAA 137
Cdd:cd17473   60 DRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGE-ERAKMLGLQSAAMSLGGV 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 138 LGPILGGALLErFWWGSVFLINvpVVAIALVATAIIAPHNHPDPSKkwdlvsslyamvglvGTVLVIKELAHiPQNWVLI 217
Cdd:cd17473  139 VFLLLGGALAE-IGWRAPFLVY--LLALPVLILVLLFLPEPARKSK---------------SAASPGAATAA-ALPWKRV 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 218 AGALASAVIGFVLFvrrqgrleeplieFSIFRNRAFaggslaaffamftiagaqlattqRFQLVEGFTPLQAGLLVAAIA 297
Cdd:cd17473  200 LPIYFLAFLAMLLF-------------YVIPIQLPF-----------------------LLQERGGGSAALIGLALAIAS 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 298 LGALPSGVLGAAILHIVGLRIIISGSLAIAALGLALAVLAsanGSLPLLVVSFIVTGFGLGGTFAVASAAIMGNAPPRKA 377
Cdd:cd17473  244 LAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALA---SGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELR 320

                 ....*.
gi 738363981 378 GMAASI 383
Cdd:cd17473  321 GRAMGI 326
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
8-175 1.81e-08

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 56.43  E-value: 1.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   8 LLITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPA 87
Cdd:cd17323    9 FVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIA 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  88 FLIGARALLAVGAAAMMpATLALIRLAFDDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPVVAIAL 167
Cdd:cd17323   89 MLIILRFLQGFFGSSPL-AIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCL 167

                 ....*...
gi 738363981 168 VATAIIAP 175
Cdd:cd17323  168 ILIFLFLP 175
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
21-182 5.07e-08

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 54.88  E-value: 5.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  21 LPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVGA 100
Cdd:COG2807   41 LPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 101 AAMMPATLALIRLAFddPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPVVAIALVATAIIAPHNHPD 180
Cdd:COG2807  121 AVGNVLLPGLIKRWF--PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAA 198

                 ..
gi 738363981 181 PS 182
Cdd:COG2807  199 AA 200
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
12-175 6.97e-08

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 54.67  E-value: 6.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   12 LDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIG 91
Cdd:TIGR00895  31 YDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLI 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   92 ARALLAVGAAAMMPATLALIRlAFDDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPVVAIALVATA 171
Cdd:TIGR00895 111 LRFLAGLGLGGLMPNLNALVS-EYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLM 189

                  ....
gi 738363981  172 IIAP 175
Cdd:TIGR00895 190 RFLP 193
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
19-383 8.25e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 54.09  E-value: 8.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  19 TALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAV 98
Cdd:COG0738   29 PLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGL 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  99 GAAAMMPATLALIRLAFDDPRERNIAI--AIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPVVAIALVATAIIAPH 176
Cdd:COG0738  109 GLGLLDVAANPYVAALGPETAASRLNLlhAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPE 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 177 NHPDPSKKWDLVSSLyamvglvgtvlvikelahipqnwvliagalasavigfvlfvrrqgrleeplieFSIFRNRAFAGG 256
Cdd:COG0738  189 IEEEEEEAAGSAASL-----------------------------------------------------KSLLKNPRLLLG 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 257 SLAAFFAMFTIAGAQLATTQRFQLVEGFTPLQAGLLVAAIALGALPSGVLGAAILHIVGLRIIISGSLAIAALGLALAVL 336
Cdd:COG0738  216 GLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALL 295
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 738363981 337 AsanGSLPLLVVSFIVTGFGLGGTFAVASAAIMGNAPPRKAGMAASI 383
Cdd:COG0738  296 A---PGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAV 339
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
1-168 9.25e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 54.14  E-value: 9.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   1 MTVGAGLLLITLDNSILYTALPTLTADLGASGSSTLWIINAypLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAA 80
Cdd:cd17489  197 LPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYA--IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLL 274
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  81 AFSPNPAFLIGARALLAVGAAAMMPATLALIrLAFDDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINV 160
Cdd:cd17489  275 SFAGSPWMLLLAAVLYGLGFGLLFPALQALA-VDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAA 353

                 ....*...
gi 738363981 161 PVVAIALV 168
Cdd:cd17489  354 VVVLLALV 361
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
12-173 2.05e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 52.97  E-value: 2.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  12 LDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIG 91
Cdd:cd17365   13 FDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  92 ARALLAVGAAAMMPATLALIRlAFDDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLIN--VPVVAIALVA 169
Cdd:cd17365   93 LRFLTGLGLGAAMPNAITLVS-EYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGgvPPLILLPLLR 171

                 ....
gi 738363981 170 TAII 173
Cdd:cd17365  172 GTLL 175
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
59-173 4.41e-07

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 51.80  E-value: 4.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  59 RIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVGAAAMMPATLALIrLAFDDPRERNIAIAIWGSLSIAGAAL 138
Cdd:cd17474  261 RFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLV-TELAPEEERGTASSLYNFVRFLGQAV 339
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 738363981 139 GPILGGALLERFWWGSVFLINVPVVAIALVATAII 173
Cdd:cd17474  340 GPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
59-406 1.03e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 51.06  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  59 RIGHRRMFVVGLWIFGAASLAAAFSPNP-------AFLIGARALLAVGAAAMMPATLALIRLAFDDPRERNIAIAIWGSL 131
Cdd:COG2211   76 RWGRRRPWILIGAIPLALSFVLLFTAPDlsptgklIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAF 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 132 SIAGAALGPILGGALLErfWWGSVFLINVPVVAIALVATAIIAphnhpdpskkwdlvsslyamvgLVGTVLVIKELAHIP 211
Cdd:COG2211  156 AGLGGLLASVLPPPLVA--AFGGDAALGYRLTALIFAVLGLLA----------------------FLLTFFGTKERPVPE 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 212 QNWVLIAGALASavigfvlfvrrqgrleepliefsIFRNRAFAGGSLAAFFAMFTIAGAQLATTQRFQLVEGFTPLQAGL 291
Cdd:COG2211  212 EEKVSLKESLKA-----------------------LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGL 268
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 292 LVAAIALGALPSGVLGAAILHIVGLRIIISGSLAIAAlGLALAVLASANGSLPLLVVSFIVTGFGLGGTFAVASAAIMGN 371
Cdd:COG2211  269 LLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA-LGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADV 347
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 738363981 372 APP-------RKAGMAASIEEVSYEMGSLSAVALLGSLLTFV 406
Cdd:COG2211  348 VDYdewktgrRREGLYFGIFTFAIKLGQALAGALAGLLLALF 389
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
8-195 1.39e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 47.20  E-value: 1.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   8 LLITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPA 87
Cdd:cd17489    6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  88 FLIGARALLAVGAAAMMPATLALIRLAFDDPReRNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPVVAIAL 167
Cdd:cd17489   86 LLLVLRLIHGIGWGAFTTAAATLVADIIPPSR-RGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLAL 164
                        170       180
                 ....*....|....*....|....*...
gi 738363981 168 VATAIIAPHNHPDPSKKWDLVSSLYAMV 195
Cdd:cd17489  165 LLVFLVKDPPPVAAEEAEAGTRAFRRLV 192
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
58-383 3.43e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 46.01  E-value: 3.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  58 DRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVGAAAMMPATLALIRLAFddPRERNIAIAIWGSLSIAGAA 137
Cdd:cd17478   56 DRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAA--GGRRGLAMSIFSVGGNLGFA 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 138 LGPILGGALLERFWwgsvFLINVPVVAIALVATAIIAPHNHPDPSKKwdlvsslyamvglvgtVLVIKELAHIPQNWVLI 217
Cdd:cd17478  134 LGPLIAAALVALFG----GLGLLILLIIPGLAVALLLLRLRPLKKPE----------------AKKAAAKSSARSTLKGV 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 218 AGALASAVIGFVLfvrrqgrleepliefsifrnRAFAGGSLAAFFAMFTIAgaqlattqrfqlvEGFTPLQAGLLVAAIA 297
Cdd:cd17478  194 WRALLLLLIIVFL--------------------RSWVLSSLTTFLPFYLVQ-------------RGYSLVFAGLLLSLFL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 298 LGALPSGVLGAAILHIVGLRIIISGSLAIAALGLALAVLAsangSLPLLVVSFIVTGFGLGGTFAVaSAAIMGNAPPRKA 377
Cdd:cd17478  241 FAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLT----PGIWSYILLVLAGFLLFASFPV-TVVLAQELLPGNV 315

                 ....*.
gi 738363981 378 GMAASI 383
Cdd:cd17478  316 GLASGL 321
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
58-168 4.88e-05

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 45.65  E-value: 4.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  58 DRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVGAAAMMPATLALIRLAFDDPRERNIAIAIWG--SLSiag 135
Cdd:PRK11043  66 DRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPlvALS--- 142
                         90       100       110
                 ....*....|....*....|....*....|...
gi 738363981 136 AALGPILGGALLERFWWGSVFLInvpVVAIALV 168
Cdd:PRK11043 143 PALAPLLGAWLLNHFGWQAIFAT---LFAITLL 172
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
19-156 5.05e-05

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 45.40  E-value: 5.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  19 TALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAV 98
Cdd:PRK10473  24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 738363981  99 GAAAMMPATLALIRLAFDDPRERNIAIAIWGSLSIAgAALGPILGGALLERFWWGSVF 156
Cdd:PRK10473 104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCII-PVLAPVLGHLIMLKFPWQSLF 160
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
24-175 7.37e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 44.86  E-value: 7.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  24 LTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRR--MFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVGAA 101
Cdd:COG2271  207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG 286
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 738363981 102 AMMPATLALIRLAFDdPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPVVAIALVATAIIAP 175
Cdd:COG2271  287 GAFGLLWALAAELFP-KKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
5-179 1.11e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.47  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   5 AGLLLITLDNSILYTALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSP 84
Cdd:cd17477    3 LSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  85 NPAFLIGARALLAVGAAAMMPATLALIrLAFDDPRERNIAIAIWGSLSIAGAALGPILGGALLER----FWWGSVFLInV 160
Cdd:cd17477   83 SPWVWFLLRFVMGIGLAGLFVVSESWL-NALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAgalpFLIAAVLLL-L 160
                        170
                 ....*....|....*....
gi 738363981 161 PVVAIALVATAIIAPHNHP 179
Cdd:cd17477  161 ALVPLLLTRRAAPEIEEAE 179
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
58-168 1.21e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 44.18  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  58 DRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVGAAAMMPATLALIRLafDDPRErnIAIAIWG---SLSIA 134
Cdd:cd17391  265 DRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAK--ITPKE--VAGRIFGynqSFQYL 340
                         90       100       110
                 ....*....|....*....|....*....|....
gi 738363981 135 GAALGPILGGALLERFWWGSVFLINVPVVAIALV 168
Cdd:cd17391  341 GNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAI 374
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
59-174 1.47e-04

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 44.11  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  59 RIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVGAAAMMPATLALIRLAFdDPRERNIAIAIWGSLSI-AGAA 137
Cdd:cd17335  259 RFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAA-PPGLRATAQGLLQGLYFgLGGG 337
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 738363981 138 LGPILGGALLERFWWGSVFLINVPVVAIALVATAIIA 174
Cdd:cd17335  338 LGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQ 374
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
15-171 2.33e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 43.31  E-value: 2.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  15 SILYTAL-PTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGAR 93
Cdd:cd17324  215 FALYTYLaPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGL 294
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 738363981  94 ALLAVGAAAMMPA-TLALIRLAfddPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPVVAIALVATA 171
Cdd:cd17324  295 VLWGLGFFAAHSAlQTRVLRLA---PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
58-305 2.46e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 43.41  E-value: 2.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  58 DRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVgAAAMMPATLALIrlAFDDPRERN-IAIAIWGSLSIAGA 136
Cdd:cd17391   61 DRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGV-FSGYVPNATALI--ASQTPKEKSgWALGTLSTGVVAGT 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 137 ALGPILGGALLERFWWGSVFLINVPVVAIALVATAI--------IAPHNHPDPSKKWDLVSSLYAMVGLVGTVLV----- 203
Cdd:cd17391  138 LIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFfvkedfkpVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIiqlan 217
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 204 ----------IKELAHIPQNWVLIAGALASAV-IGFVLFVRRQGRLEEpliefSIFRNRAFAGGSLAAFFAMFTIAGAQl 272
Cdd:cd17391  218 qsiepiltlyIRQLMGDASNLAFISGLVFSATgVSSLLSAPRLGKLGD-----RIGHHRILLGALLASALLYIPQAFVQ- 291
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 738363981 273 attqrfqlvegfTPLQAGLL--VAAIALGALPSGV 305
Cdd:cd17391  292 ------------TPWQLGILrfLLGLATGGLLPAI 314
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
29-184 4.57e-04

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 42.59  E-value: 4.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  29 GASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAF-------SPNPAFLIGARALLAVGAA 101
Cdd:cd17385   30 GVSDTIIGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSGGCTILFGFldrvpdgTVFIALCFLVRIVEAVGFA 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981 102 AMMPATLALIRLAFDDprerNIAiAIWGSLSI---AGAALGPILGGALLERFWWGSVFLINVPVVAIALVATAIIAPHNH 178
Cdd:cd17385  110 AFITASFAIIAKEFPN----NIA-TVLGTLETfsgLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPLNMFILPRYD 184

                 ....*.
gi 738363981 179 PDPSKK 184
Cdd:cd17385  185 DDPSPK 190
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
17-177 1.31e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 41.05  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  17 LYTALPTLTADLGASGSSTLW---IINAYPLVMAGLLLGAGTLGDRIGHRRMFVV-GLWIFGAASLAAAFSPNPAFLIGA 92
Cdd:cd17490   12 QYVYVPFLSPYAESLGASLSMigiILGAYGISQMLLRIPLGILSDRIGKRKLFIIiGLLFTVLASLIMILFPSPWGLLIA 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  93 RALLAVGAAAMMPATLALIrlAFDDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLINVPVVAIALVATAI 172
Cdd:cd17490   92 RFLSGIAAATWVSFTVLYA--SYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLF 169

                 ....*
gi 738363981 173 IAPHN 177
Cdd:cd17490  170 IKEER 174
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
5-175 1.59e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 40.63  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981   5 AGLLLITLDNSILYTALPT-----LTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLA 79
Cdd:cd17473  200 LPIYFLAFLAMLLFYVIPIqlpflLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLL 279
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  80 AAFSPNPAFLIGARALLAVGAAAMMPATLALIrLAFDDPRERNIAIAIWGSLSIAGAALGPILGGALLERFWWGSVFLIN 159
Cdd:cd17473  280 LALASGLWVVLLGAILAGLGFGLLLPTLNSWA-MSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLI 358
                        170
                 ....*....|....*.
gi 738363981 160 VPVVAIALVATAIIAP 175
Cdd:cd17473  359 LGVLALVLAIVLLLLR 374
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
58-185 1.65e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 40.72  E-value: 1.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  58 DRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVGAAAMMPATLALIRLAFDDPRERNIAIAIWGSLSIAGAA 137
Cdd:cd17355   63 DRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSL 142
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 738363981 138 LGPILGGALLERFWWGSVFLInVPVVAIALVATAIIAPHNHPDPSKKW 185
Cdd:cd17355  143 VFLPLGAALIEAFGWRTALLV-LALLALLVLVPVLLLLRRRPADLALR 189
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
58-184 1.80e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 40.66  E-value: 1.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  58 DRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVGA--AAMMPATLALIRlafddPRERNIAIAIWGsLSIAG 135
Cdd:cd17472   57 DRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAisSVVMALLADLTR-----EENRTKAMALIG-ASIGI 130
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 738363981 136 AALGPILGGALLERFW-WGSVFLINVPVVAIALVATAIIAPHNHPDPSKK 184
Cdd:cd17472  131 AFAISMVLGPLLAAHLgVSGLFLITAILSLVSLLILLFFVPDPPKIVQIS 180
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
58-111 2.01e-03

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 40.26  E-value: 2.01e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 738363981  58 DRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVGAAAMMPATLALI 111
Cdd:cd17317   50 DRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLG 103
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
58-158 3.01e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 39.85  E-value: 3.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  58 DRIGHRRMFVVGLWIFGAASLA--AAFSPNPAFLIGARALLAVGAAAMMPATLALIRLAFDdPRERNIAIAIWGSLSIAG 135
Cdd:cd17380   59 DRFGGKKVLLLAVALWSLATLLtpLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVP-VSERSRAVSIVTAGSYLG 137
                         90       100
                 ....*....|....*....|...
gi 738363981 136 AALGPILGGALLERFWWGSVFLI 158
Cdd:cd17380  138 TLLGGLIGPLLLEYYGWPSVFYF 160
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
24-148 3.35e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.52  E-value: 3.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  24 LTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVGAAAM 103
Cdd:cd17329   26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 738363981 104 MPATLALIrLAFDDPRERNIAIAIWGSLSIAGAALGPILGGALLE 148
Cdd:cd17329  106 EPASEAMI-ADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL 149
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
20-172 3.37e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 39.51  E-value: 3.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  20 ALPTLTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVG 99
Cdd:PRK11102  13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 738363981 100 AAAMMPATLALIRLAFDDPRERNIAIAIWGSLSIAgAALGPILGGALLERFWWGSVF--LINVPVVAIALVATAI 172
Cdd:PRK11102  93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIA-PLLAPIIGGWLLVWFSWHAIFwvLALAAILAAALVFFFI 166
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
24-173 6.12e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 38.69  E-value: 6.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  24 LTADLGASGSSTLWIINAYPLVMAGLLLGAGTLGDRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLA-VGAAA 102
Cdd:cd17352   29 LLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGVLGgLGLGL 108
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 738363981 103 MMPATLALIRLAFDDPRerniaiAIWGSLSIAGAALG----PILGGALLERFWWGSVFLINVPVVAIALVATAII 173
Cdd:cd17352  109 IYSPAIVIVGQYFEKKR------GLATGIAVAGSGVGtfvfPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLL 177
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
58-146 6.29e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 38.76  E-value: 6.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  58 DRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVGAAAMMPATLALIRLAFDDPReRNIAIAIWGSLSIAGAA 137
Cdd:cd17328   59 DRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEK-RTRALGVFYFAIPLGSG 137

                 ....*....
gi 738363981 138 LGPILGGAL 146
Cdd:cd17328  138 LGYVVGGLV 146
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
58-174 7.60e-03

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 38.71  E-value: 7.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  58 DRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVGAAAMMPATLALIRLAFDDPRERNIAIAI-WGSLSIaGA 136
Cdd:cd17384   56 NRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAGMGMLASLYPDDKERGKAMGIaLGGLAL-GV 134
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 738363981 137 ALGPILGGALLERFWWGSVFLInvpvvaIALVATAIIA 174
Cdd:cd17384  135 LVGPPFGGVMYEFVGKSAPFLI------LAFLALLDGA 166
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
58-181 7.99e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 38.37  E-value: 7.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  58 DRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVGAAAMMPATLALIRLAFdDPRERNIAIAIWGSLSIAGAA 137
Cdd:cd17475   56 DRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWF-PPRERGLAMGIRQTGVPLGGA 134
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 738363981 138 LGPILGGALLERFWWGSVFLinvpVVAIALVATAIIAPHNHPDP 181
Cdd:cd17475  135 LAAALLPPLALHYGWRAAFV----VAGLVSILAAVLFWLFYREP 174
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
58-169 8.73e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 38.29  E-value: 8.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  58 DRIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVGAAA---MMPATLALIRlafdDPRERNIAIAIWGSLSIA 134
Cdd:cd17370  259 DRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAqesIERAAVADLV----PAELRGTAYGLFNTVVGI 334
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 738363981 135 GAALGPILGGALLERFWWGSVFLINVPVVAIALVA 169
Cdd:cd17370  335 GWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
59-168 9.05e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 38.33  E-value: 9.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738363981  59 RIGHRRMFVVGLWIFGAASLAAAFSPNPAFLIGARALLAVGAAAMMPATLALIRLAFdDPRERNIAIAIWGSLSIAGAAL 138
Cdd:cd17330  237 RLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSV-PSKEQGKAQGIIQSLQSLARII 315
                         90       100       110
                 ....*....|....*....|....*....|
gi 738363981 139 GPILGGALLERFWWGSVFLINVPVVAIALV 168
Cdd:cd17330  316 GPLLAGPLYSFLGPGVPFLLAAGLLLIALF 345
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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