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Conserved domains on  [gi|739103881|ref|WP_036974456|]
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MULTISPECIES: diacylglycerol kinase family protein [Pseudoalteromonas]

Protein Classification

diacylglycerol/lipid kinase family protein( domain architecture ID 11446635)

diacylglycerol/lipid kinase family protein may catalyze the ATP-dependent phosphorylation of diacylglycerol and/or other lipids, and is involved in the phospholipid biosynthetic process

CATH:  3.40.50.10330
EC:  2.7.1.-
Gene Ontology:  GO:0008654|GO:0001727|GO:0005524|GO:0016310
SCOP:  3001940

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 2-282 1.65e-64

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


:

Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 203.93  E-value: 1.65e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881   2 LIIIKP-SDKKNTKQSVEWLLNECTLRHIEPQLFFTTGHFESDHKAIANLAKHVNQAVVIGGDGSLHLAINALFGCDCSI 80
Cdd:COG1597    6 LLIVNPaSGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAGTGPPL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881  81 ALLPAGTGNDFAR--GFAFKPQQWRDAVFSGHTQLIDVGKINQRYFINVAGVGFDADVVSQLNQV--GRFTAFGYLWQGI 156
Cdd:COG1597   86 GILPLGTGNDFARalGIPLDPEAALEALLTGRTRRIDLGRVNGRYFLNVAGIGFDAEVVERANRAlkRRLGKLAYVLAAL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881 157 KQLFSFQAKSLSGVFADKHEEFTNLVTLFANHHYFGGGLKIAPHAILNDGELECYRMPAGNLVKNLRSFLHLIFVKHHNL 236
Cdd:COG1597  166 RALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLSRLRLLRLLPRLLRGRHLRH 245

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 739103881 237 NELQYCRLSRAEIHTAG-LLIEADGELVGV-TPAKVVMYHQALRFHLP 282
Cdd:COG1597  246 PGVRYFRAREVEIESDRpLPVQLDGEPLGLaTPLEFEVLPGALRVLVP 293
 
Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 2-282 1.65e-64

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 203.93  E-value: 1.65e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881   2 LIIIKP-SDKKNTKQSVEWLLNECTLRHIEPQLFFTTGHFESDHKAIANLAKHVNQAVVIGGDGSLHLAINALFGCDCSI 80
Cdd:COG1597    6 LLIVNPaSGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAGTGPPL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881  81 ALLPAGTGNDFAR--GFAFKPQQWRDAVFSGHTQLIDVGKINQRYFINVAGVGFDADVVSQLNQV--GRFTAFGYLWQGI 156
Cdd:COG1597   86 GILPLGTGNDFARalGIPLDPEAALEALLTGRTRRIDLGRVNGRYFLNVAGIGFDAEVVERANRAlkRRLGKLAYVLAAL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881 157 KQLFSFQAKSLSGVFADKHEEFTNLVTLFANHHYFGGGLKIAPHAILNDGELECYRMPAGNLVKNLRSFLHLIFVKHHNL 236
Cdd:COG1597  166 RALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLSRLRLLRLLPRLLRGRHLRH 245

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 739103881 237 NELQYCRLSRAEIHTAG-LLIEADGELVGV-TPAKVVMYHQALRFHLP 282
Cdd:COG1597  246 PGVRYFRAREVEIESDRpLPVQLDGEPLGLaTPLEFEVLPGALRVLVP 293
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
 2-278 1.02e-35

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 129.55  E-value: 1.02e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881    2 LIIIKP-SDKKNTKQSVEWLLNECTLRHIEPQLFFTTGHFESDHKAIANLAKHVNQAVVIGGDGSLHLAINALFGCDCSI 80
Cdd:TIGR00147   5 PAILNPtAGKSNDNKPLREVIMLLREEGMEIHVRVTWEKGDAARYVEEARKFGVDTVIAGGGDGTINEVVNALIQLDDIP 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881   81 AL--LPAGTGNDFARGFAFKPQ--QWRDAVFSGHTQLIDVGKINQRY-FINVAGVGFDADVVSQLNQVgRFTAFG---YL 152
Cdd:TIGR00147  85 ALgiLPLGTANDFARSLGIPEDldKAAKLVIAGDARAIDMGQVNKQYcFINMAGGGFGTEITTETPEK-LKAALGslsYI 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881  153 WQGIKQLFSFQAKSLSGVFADKHEEFTNLVTLFANHHYFGGGLKIAPHAILNDGELECYRMPAGNLVKNLRSFLHLIFVK 232
Cdd:TIGR00147 164 LSGLMRMDTLQPFRCEIRGEGEHWQGEAVVFLVGNGRQAGGGQKLAPDASINDGLLDLRIFTNDNLLPALVLTLMSDEGK 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 739103881  233 HHNLNELQYCRLSRAEIHTA-GLLIEADGELVGVTPAKVVMYHQALR 278
Cdd:TIGR00147 244 HTDNPNIIYGKASRIDIQTPhKITFNLDGEPLGGTPFHIEILPAHLR 290
PRK13057 PRK13057
lipid kinase;
47-282 1.07e-29

lipid kinase;


Pssm-ID: 183857 [Multi-domain]  Cd Length: 287  Bit Score: 113.47  E-value: 1.07e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881  47 IANLAKHVNQAVVIGGDGSLHLAINALFGCDCSIALLPAGTGNDFAR--GFAFKPQQWRDAVFSGHTQLIDVGKINQRYF 124
Cdd:PRK13057  44 IEAYADGVDLVIVGGGDGTLNAAAPALVETGLPLGILPLGTANDLARtlGIPLDLEAAARVIATGQVRRIDLGWVNGHYF 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881 125 INVAGVGFDADVVSQLNQVG--RFTAFGY---LWQGIKQLFSFQAKSLSGvfaDKHEEFTNLVTLFANHHYFGGGLKIAP 199
Cdd:PRK13057 124 FNVASLGLSAELARRLTKELkrRWGTLGYaiaALRVLRRSRPFTAEIEHD---GRTERVKTLQVAVGNGRYYGGGMTVAH 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881 200 HAILNDGELECYRMPAGNLVKNLRSFLHLIFVKHHNLNELQYCRLSRAEIHTAGLL-IEADGELVGVTPAKVVMYHQALR 278
Cdd:PRK13057 201 DATIDDGRLDLYSLEVAHWWRLLALLPALRRGRHGEWPDVRAFRTTELELRTRKPRpINTDGELTTYTPAHFRVLPKALR 280


                 ....
gi 739103881 279 FHLP 282
Cdd:PRK13057 281 VLAP 284
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 1-119 4.95e-14

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 67.23  E-value: 4.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881    1 MLIIIKP-SDKKNTKQ---SVEWLLNEctlRHIEPQLFFTTGhfesDHKAIANLAKHVNQA----VVIGGDGSLHLAINA 72
Cdd:pfam00781   2 LLVIVNPkSGGGKGKKllrKVRPLLNK---AGVEVELVLTEG----PGDALELAREAAEDGydriVVAGGDGTVNEVLNG 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 739103881   73 LFGC--DCSIALLPAGTGNDFARGFAFKPQQWR--DAVFSGHTQLIDVGKI 119
Cdd:pfam00781  75 LAGLatRPPLGIIPLGTGNDFARALGIPGDPEEalEAILKGQTRPVDVGKV 125
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
 2-93 6.15e-05

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 41.90  E-value: 6.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881     2 LIIIKPSDKKNT----KQSVEWLLNECtlrhiepQLFFTTGHfesDHKAIANLAKHVNQAVVI---GGDGSLHLAINALF 74
Cdd:smart00046   1 LVFVNPKSGGGKgeklLRKFRLLLNPR-------QVFDLTKK---GPAVALVIFRDVPDFNRVlvcGGDGTVGWVLNALD 70

                           90       100
                   ....*....|....*....|....
gi 739103881    75 GCD-----CSIALLPAGTGNDFAR 93
Cdd:smart00046  71 KRElplpePPVAVLPLGTGNDLAR 94
 
Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 2-282 1.65e-64

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 203.93  E-value: 1.65e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881   2 LIIIKP-SDKKNTKQSVEWLLNECTLRHIEPQLFFTTGHFESDHKAIANLAKHVNQAVVIGGDGSLHLAINALFGCDCSI 80
Cdd:COG1597    6 LLIVNPaSGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAGTGPPL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881  81 ALLPAGTGNDFAR--GFAFKPQQWRDAVFSGHTQLIDVGKINQRYFINVAGVGFDADVVSQLNQV--GRFTAFGYLWQGI 156
Cdd:COG1597   86 GILPLGTGNDFARalGIPLDPEAALEALLTGRTRRIDLGRVNGRYFLNVAGIGFDAEVVERANRAlkRRLGKLAYVLAAL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881 157 KQLFSFQAKSLSGVFADKHEEFTNLVTLFANHHYFGGGLKIAPHAILNDGELECYRMPAGNLVKNLRSFLHLIFVKHHNL 236
Cdd:COG1597  166 RALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLSRLRLLRLLPRLLRGRHLRH 245

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 739103881 237 NELQYCRLSRAEIHTAG-LLIEADGELVGV-TPAKVVMYHQALRFHLP 282
Cdd:COG1597  246 PGVRYFRAREVEIESDRpLPVQLDGEPLGLaTPLEFEVLPGALRVLVP 293
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
 2-278 1.02e-35

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 129.55  E-value: 1.02e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881    2 LIIIKP-SDKKNTKQSVEWLLNECTLRHIEPQLFFTTGHFESDHKAIANLAKHVNQAVVIGGDGSLHLAINALFGCDCSI 80
Cdd:TIGR00147   5 PAILNPtAGKSNDNKPLREVIMLLREEGMEIHVRVTWEKGDAARYVEEARKFGVDTVIAGGGDGTINEVVNALIQLDDIP 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881   81 AL--LPAGTGNDFARGFAFKPQ--QWRDAVFSGHTQLIDVGKINQRY-FINVAGVGFDADVVSQLNQVgRFTAFG---YL 152
Cdd:TIGR00147  85 ALgiLPLGTANDFARSLGIPEDldKAAKLVIAGDARAIDMGQVNKQYcFINMAGGGFGTEITTETPEK-LKAALGslsYI 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881  153 WQGIKQLFSFQAKSLSGVFADKHEEFTNLVTLFANHHYFGGGLKIAPHAILNDGELECYRMPAGNLVKNLRSFLHLIFVK 232
Cdd:TIGR00147 164 LSGLMRMDTLQPFRCEIRGEGEHWQGEAVVFLVGNGRQAGGGQKLAPDASINDGLLDLRIFTNDNLLPALVLTLMSDEGK 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 739103881  233 HHNLNELQYCRLSRAEIHTA-GLLIEADGELVGVTPAKVVMYHQALR 278
Cdd:TIGR00147 244 HTDNPNIIYGKASRIDIQTPhKITFNLDGEPLGGTPFHIEILPAHLR 290
PRK13057 PRK13057
lipid kinase;
47-282 1.07e-29

lipid kinase;


Pssm-ID: 183857 [Multi-domain]  Cd Length: 287  Bit Score: 113.47  E-value: 1.07e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881  47 IANLAKHVNQAVVIGGDGSLHLAINALFGCDCSIALLPAGTGNDFAR--GFAFKPQQWRDAVFSGHTQLIDVGKINQRYF 124
Cdd:PRK13057  44 IEAYADGVDLVIVGGGDGTLNAAAPALVETGLPLGILPLGTANDLARtlGIPLDLEAAARVIATGQVRRIDLGWVNGHYF 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881 125 INVAGVGFDADVVSQLNQVG--RFTAFGY---LWQGIKQLFSFQAKSLSGvfaDKHEEFTNLVTLFANHHYFGGGLKIAP 199
Cdd:PRK13057 124 FNVASLGLSAELARRLTKELkrRWGTLGYaiaALRVLRRSRPFTAEIEHD---GRTERVKTLQVAVGNGRYYGGGMTVAH 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881 200 HAILNDGELECYRMPAGNLVKNLRSFLHLIFVKHHNLNELQYCRLSRAEIHTAGLL-IEADGELVGVTPAKVVMYHQALR 278
Cdd:PRK13057 201 DATIDDGRLDLYSLEVAHWWRLLALLPALRRGRHGEWPDVRAFRTTELELRTRKPRpINTDGELTTYTPAHFRVLPKALR 280


                 ....
gi 739103881 279 FHLP 282
Cdd:PRK13057 281 VLAP 284
PRK11914 PRK11914
diacylglycerol kinase; Reviewed
 44-278 1.50e-26

diacylglycerol kinase; Reviewed


Pssm-ID: 237021 [Multi-domain]  Cd Length: 306  Bit Score: 105.25  E-value: 1.50e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881  44 HKAIANLAKHVNQAVVIGGDGSLHLAINALFGCDCSIALLPAGTGNDFARGFAF---KPQQWRDAVFSGHTQLIDVGKIN 120
Cdd:PRK11914  55 HLVAAALAKGTDALVVVGGDGVISNALQVLAGTDIPLGIIPAGTGNDHAREFGIptgDPEAAADVIVDGWTETVDLGRIQ 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881 121 -----QRYFINVAGVGFDADVVSQLNQV----GRFTafgYLWQGIKQLFSFQAKSLSGVFaDKHEEFTNLVTL--FANHH 189
Cdd:PRK11914 135 dddgiVKWFGTVAATGFDSLVTDRANRMrwphGRMR---YNLAMLAELSKLRPLPFRLVL-DGTEEIVTDLTLaaFGNTR 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881 190 YFGGGLKIAPHAILNDGELECYRMPAGNLVKNLRSFLHLIFVKHHNLNELQYCRLSRAEIHTAGLLIEADGELVGVTPAK 269
Cdd:PRK11914 211 SYGGGMLICPNADHTDGLLDITMVQSASRTRLLRLFPTVFKGTHVELDEVSTARAKTVHVECPGINAYADGDFACPLPAE 290


                 ....*....
gi 739103881 270 VVMYHQALR 278
Cdd:PRK11914 291 ISAVPGALQ 299
PRK13337 PRK13337
putative lipid kinase; Reviewed
 36-282 2.84e-21

putative lipid kinase; Reviewed


Pssm-ID: 183982 [Multi-domain]  Cd Length: 304  Bit Score: 90.88  E-value: 2.84e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881  36 TTGhfESDHKAIANLAKHVNQAVVI--GGDGSLHLAINALFGCDC--SIALLPAGTGNDFAR--GFAFKPQQWRDAVFSG 109
Cdd:PRK13337  40 TTG--PGDATLAAERAVERKFDLVIaaGGDGTLNEVVNGIAEKENrpKLGIIPVGTTNDFARalHVPRDIEKAADVIIEG 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881 110 HTQLIDVGKINQRYFINVAGVG----FDADVVSQLNQ-VGRftaFGYLWQGIKQLFSFQAKSLSGVFADKHEEFTNLVTL 184
Cdd:PRK13337 118 HTVPVDIGKANNRYFINIAGGGrlteLTYEVPSKLKTmLGQ---LAYYLKGIEMLPSLKATDVRIEYDGKLFQGEIMLFL 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881 185 FANHHYFGGGLKIAPHAILNDGELECYrmpagnLVK--NLRSFLHLIFV----KHHNLNELQYCRLSRAEIHT-AGLLIE 257
Cdd:PRK13337 195 LGLTNSVGGFEKLAPDASLDDGYFDLI------IVKkaNLAELIHIATLalrgEHIKHPKVIYTKANRIKVSSfDKMQLN 268

                        250       260
                 ....*....|....*....|....*
gi 739103881 258 ADGELVGVTPAKVVMYHQALRFHLP 282
Cdd:PRK13337 269 LDGEYGGKLPAEFENLYRHIEVFVP 293
PRK13054 PRK13054
lipid kinase; Reviewed
 46-282 1.07e-20

lipid kinase; Reviewed


Pssm-ID: 237281 [Multi-domain]  Cd Length: 300  Bit Score: 89.16  E-value: 1.07e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881  46 AIANLAKHVnqaVVIGGDGSLHLAINALFGCD----CSIALLPAGTGNDFARGfAFKPQQWRDA---VFSGHTQLIDVGK 118
Cdd:PRK13054  52 ALALGVATV---IAGGGDGTINEVATALAQLEgdarPALGILPLGTANDFATA-AGIPLEPDKAlklAIEGRAQPIDLAR 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881 119 INQR-YFINVAGVGFDADVVSQlnqvgrfT------AFG---YLWQGIKQLFSFQAKSLSGVFADKHEEFTNLVTLFANH 188
Cdd:PRK13054 128 VNDRtYFINMATGGFGTRVTTE-------TpeklkaALGgvaYLIHGLMRMDTLKPDRCEIRGPDFHWQGDALVIGIGNG 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881 189 HYFGGGLKIAPHAILNDGELECYRMPA-GNLVKNLrsfLHLIFVKHHNLNELQYCRLSRAEIHTA-GLLIEADGE-LVG- 264
Cdd:PRK13054 201 RQAGGGQQLCPEALINDGLLDLRILPApQELLPTL---LSTLTGGSEDNPNIIRARLPWLEIQAPhELTFNLDGEpLSGr 277

                        250       260
                 ....*....|....*....|...
gi 739103881 265 -----VTPAkvvmyhqALRFHLP 282
Cdd:PRK13054 278 hfrieVLPA-------ALRCRLP 293
PRK00861 PRK00861
putative lipid kinase; Reviewed
 29-282 1.27e-17

putative lipid kinase; Reviewed


Pssm-ID: 234850 [Multi-domain]  Cd Length: 300  Bit Score: 80.82  E-value: 1.27e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881  29 IEPQL----FFTTGHFESDHKAIANLAKHVNQAVVIGGDGSLHLAINALFGCDCSIALLPAGTGNDFARGFAFkPQQWR- 103
Cdd:PRK00861  29 LEPEMdldiYLTTPEIGADQLAQEAIERGAELIIASGGDGTLSAVAGALIGTDIPLGIIPRGTANAFAAALGI-PDTIEe 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881 104 --DAVFSGHTQLIDVGKINQRYFINVAGVGFDADVVSQLNQ--VGRFTAFGYLWQGIKQLFSFQAKSLSGVFADKHEEFT 179
Cdd:PRK00861 108 acRTILQGKTRRVDVAYCNGQPMILLAGIGFEAETVEEADReaKNRFGILAYILSGLQQLRELESFEVEIETEDQIITTN 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881 180 NLVTLFANhhyfggglkIAP----------HAILNDGELECYRMPAGNLVKNLRSFLHLI--FVKHHNL--NELQYCRLS 245
Cdd:PRK00861 188 AVAVTVAN---------AAPptsvlaqgpgAVIPDDGLLDVTIVAPKNLAEAVAASYHLLqtALQGNPAerDDIGYLRAK 258

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 739103881 246 RAEIHT---AGLLIeaDGELVGVTPAKVVMYHQALRFHLP 282
Cdd:PRK00861 259 QVKITTdppQKVVI--DGEVVGTTPIEIECLPRSLKVFAP 296
PRK13059 PRK13059
putative lipid kinase; Reviewed
 58-261 5.37e-17

putative lipid kinase; Reviewed


Pssm-ID: 183858  Cd Length: 295  Bit Score: 78.93  E-value: 5.37e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881  58 VVIGGDGSLHLAINALFGCDCS--IALLPAGTGNDFAR--GFAFKPQQWRDAVFSGHTQLIDVGKINQRYFINVAGVGFD 133
Cdd:PRK13059  61 LIAGGDGTVDNVVNAMKKLNIDlpIGILPVGTANDFAKflGMPTDIGEACEQILKSKPKKVDLGKINDKYFINVASTGLF 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881 134 ADvVSQ---LNQVGRFTAFGYLWQGIKQLFSFqaKSLSgvfadkheeftnlVTLFANHHYF--------------GGGLK 196
Cdd:PRK13059 141 TD-VSQktdVNLKNTIGKLAYYLKGLEELPNF--RKLK-------------VKVTSEEVNFdgdmylmlvfngqtAGNFN 204

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 739103881 197 IAPHAILNDGELECYRMPAGnLVKNLRSFLHLIFVKHH--NLNELQYCRLSRAEIHTA-GLLIEADGE 261
Cdd:PRK13059 205 LAYKAEVDDGLLDVIIIKAC-PIIDLIPLFIKVLKGEHleDVNGLIYFKTDKLEIESNeEIVTDIDGE 271
PRK13055 PRK13055
putative lipid kinase; Reviewed
 48-279 2.76e-15

putative lipid kinase; Reviewed


Pssm-ID: 237282 [Multi-domain]  Cd Length: 334  Bit Score: 74.64  E-value: 2.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881  48 ANLAKHVNQA-----VVIGGDGSLHLAINALFGCD--CSIALLPAGTGNDFARGFAF---KPQQWRDAVFSGHTQLIDVG 117
Cdd:PRK13055  49 KNEAKRAAEAgfdliIAAGGDGTINEVVNGIAPLEkrPKMAIIPAGTTNDYARALKIprdNPVEAAKVILKNQTIKMDIG 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881 118 KINQ-RYFINVAGVG----FDADVVSQLNqvgrfTAFG---YLWQGIKQLfsfqaKSLSGVFAD---KHEEFTNLVTLF- 185
Cdd:PRK13055 129 RANEdKYFINIAAGGslteLTYSVPSQLK-----SMFGylaYLAKGAELL-----PRVSPVPVRityDEGVFEGKISMFf 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881 186 -ANHHYFGGGLKIAPHAILNDGELECYrmpagnLVK--NLRSFLHLIFV-----KHHNLNELQYCRLSRAEIHTAG---L 254
Cdd:PRK13055 199 lALTNSVGGFEQIVPDAKLDDGKFTLI------IVKtaNLFELLHLMALilnggKHIDDPRVIYIKTSKLTIEPLGddrL 272

                        250       260
                 ....*....|....*....|....*
gi 739103881 255 LIEADGELVGVTPAKVVMYHQALRF 279
Cdd:PRK13055 273 MVNLDGEYGGDAPMTFENLKQHIEF 297
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 1-119 4.95e-14

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 67.23  E-value: 4.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881    1 MLIIIKP-SDKKNTKQ---SVEWLLNEctlRHIEPQLFFTTGhfesDHKAIANLAKHVNQA----VVIGGDGSLHLAINA 72
Cdd:pfam00781   2 LLVIVNPkSGGGKGKKllrKVRPLLNK---AGVEVELVLTEG----PGDALELAREAAEDGydriVVAGGDGTVNEVLNG 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 739103881   73 LFGC--DCSIALLPAGTGNDFARGFAFKPQQWR--DAVFSGHTQLIDVGKI 119
Cdd:pfam00781  75 LAGLatRPPLGIIPLGTGNDFARALGIPGDPEEalEAILKGQTRPVDVGKV 125
YegS_C pfam19279
YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal ...
 126-278 2.12e-11

YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal domain found in the YegS protein. It is related to the beta sandwich domain of NAD kinases. The structure of YegS reveals a two-domain protein with the active site crevice found between the two domains. The C-terminal domain contains 13 beta-strands and two alpha-helices. The likely substrate for YegS is phosphatidylglycerol.


Pssm-ID: 437111  Cd Length: 158  Bit Score: 60.67  E-value: 2.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881  126 NVAGVGFDAdVVSQLNQVGRFT--AFGYLWQGIKQLFSFQAKSLSGVFADKHEEFTNLVTLFANHHYFGGGLKIAPHAIL 203
Cdd:pfam19279   1 GSVYAGVDA-RVNRRANRSRLLpgALSYPAAALRALATFRPLRYRVTVDGEVREFSAALVAVANSGYYGGGMRIAPDARV 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 739103881  204 NDGELECYRMPAGNLVKNLRSFLHLIFVKHHNLNELQYCRLSRAEIHTAGLLI-EADGELVGVTPAKVVMYHQALR 278
Cdd:pfam19279  80 DDGLLDVVVIEAASRRTLLRLLPKVYDGRHVRLPQVEVLRGREVRIEADRPLPaGADGEVLGPLPVRVEVLPGALR 155
PRK12361 PRK12361
hypothetical protein; Provisional
 27-159 7.01e-08

hypothetical protein; Provisional


Pssm-ID: 183473 [Multi-domain]  Cd Length: 547  Bit Score: 53.09  E-value: 7.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881  27 RHIEPQLFFTTGHFESDHKAIANLAKHVNQAVVIGGDGSLHLAINALFGCDCSIALLPAGTGND-----FARGFAFKP-Q 100
Cdd:PRK12361 271 AYFDLTVKLTTPEISAEALAKQARKAGADIVIACGGDGTVTEVASELVNTDITLGIIPLGTANAlshalFGLGSKLIPvE 350

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 739103881 101 QWRDAVFSGHTQLIDVGKINQRYFINVAGVGFDADVVS-----QLNQVGRFTAFGYLWQGIKQL 159
Cdd:PRK12361 351 QACDNIIQGHTQRIDTARCNDRLMLLLVGIGFEQKMIEsadreRKNALGQLAYLDGLWRAVNEN 414
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
 2-93 6.15e-05

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 41.90  E-value: 6.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739103881     2 LIIIKPSDKKNT----KQSVEWLLNECtlrhiepQLFFTTGHfesDHKAIANLAKHVNQAVVI---GGDGSLHLAINALF 74
Cdd:smart00046   1 LVFVNPKSGGGKgeklLRKFRLLLNPR-------QVFDLTKK---GPAVALVIFRDVPDFNRVlvcGGDGTVGWVLNALD 70

                           90       100
                   ....*....|....*....|....
gi 739103881    75 GCD-----CSIALLPAGTGNDFAR 93
Cdd:smart00046  71 KRElplpePPVAVLPLGTGNDLAR 94
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
45-69 8.26e-03

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 36.98  E-value: 8.26e-03
                         10        20
                 ....*....|....*....|....*.
gi 739103881  45 KAIANLAKH-VNQAVVIGGDGSLHLA 69
Cdd:PRK03202  84 KAIENLKKLgIDALVVIGGDGSYMGA 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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