NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|739510088|ref|WP_037369773|]
View 

HPr family phosphocarrier protein [Amycolatopsis orientalis]

Protein Classification

HPr family phosphocarrier protein( domain architecture ID 10788234)

HPr family phosphocarrier protein is part of a phosphoenolpyruvate-dependent phosphotransferase (PTS)-like system that catalyzes the phosphorylation of incoming substrates with their concomitant translocation across the cell membrane

CATH:  3.30.1340.10
Gene Ontology:  GO:0008982
PubMed:  12405346
SCOP:  4001693
TCDB:  8.A.8

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 8-97 6.69e-27

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


:

Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 94.02  E-value: 6.69e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739510088  8 YQRRIVVASRVGLHARPAGLVAQTAAAQPAKVRIAKvsggaAGDPVDAGSVLSLMTLGAAHGDEVELSADGANAQESVDV 87
Cdd:COG1925   2 LEREVTIVNKLGLHARPAAKLVQLASKFDSEITVEK-----GGKEVNAKSIMGLMSLGAKKGDEVTITAEGPDAEEALDA 76

                        90
                ....*....|
gi 739510088 88 LVDLIAKDLD 97
Cdd:COG1925  77 LAALIESGFG 86
 
Name Accession Description Interval E-value
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 8-97 6.69e-27

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 94.02  E-value: 6.69e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739510088  8 YQRRIVVASRVGLHARPAGLVAQTAAAQPAKVRIAKvsggaAGDPVDAGSVLSLMTLGAAHGDEVELSADGANAQESVDV 87
Cdd:COG1925   2 LEREVTIVNKLGLHARPAAKLVQLASKFDSEITVEK-----GGKEVNAKSIMGLMSLGAKKGDEVTITAEGPDAEEALDA 76

                        90
                ....*....|
gi 739510088 88 LVDLIAKDLD 97
Cdd:COG1925  77 LAALIESGFG 86
PTS-HPr pfam00381
PTS HPr component phosphorylation site;
10-93 1.46e-24

PTS HPr component phosphorylation site;


Pssm-ID: 459792 [Multi-domain]  Cd Length: 79  Bit Score: 87.83  E-value: 1.46e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739510088  10 RRIVVASRVGLHARPAGLVAQTAAAQPAKVRIAKvsggaAGDPVDAGSVLSLMTLGAAHGDEVELSADGANAQESVDVLV 89
Cdd:pfam00381  1 KTVTITNPLGLHARPAALLVQLASKFDSDITLEK-----GGKKVNAKSIMGLMSLGAKQGDEITISAEGEDEEEALEALA 75


                 ....
gi 739510088  90 DLIA 93
Cdd:pfam00381 76 ALLE 79
PTS-HPr_like cd00367
Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of ...
 11-92 1.26e-19

Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate is transferred to HPr by enzyme I (EI). Phospho-HPr then transfers the phosphoryl group to one of several sugar-specific phosphoprotein intermediates. The conserved histidine in the N-terminus of HPr serves as an acceptor for the phosphoryl group of EI. In addition to the phosphotransferase proteins HPr and E1, this family also includes the closely related Carbon Catabolite Repressor (CCR) proteins which use the same phosphorylation mechanism and interact with transcriptional regulators to control expression of genes coding for utilization of less favored carbon sources.


Pssm-ID: 238217 [Multi-domain]  Cd Length: 77  Bit Score: 75.24  E-value: 1.26e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739510088 11 RIVVASRVGLHARPAGLVAQTAAAQPAKVRIAKvsggaAGDPVDAGSVLSLMTLGAAHGDEVELSADGANAQESVDVLVD 90
Cdd:cd00367   1 TVTITNPLGLHARPAALLVQLASKFKSDITLRK-----GGRKANAKSILGLMSLGAKQGDEITLSAEGEDAEEALEALAE 75


                ..
gi 739510088 91 LI 92
Cdd:cd00367  76 LL 77
PTS_HPr_family TIGR01003
Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains ...
 9-93 8.27e-19

Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS]


Pssm-ID: 273389 [Multi-domain]  Cd Length: 82  Bit Score: 73.45  E-value: 8.27e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739510088   9 QRRIVVASRVGLHARPAGLVAQTAAAQPAKVRIAKvsggaAGDPVDAGSVLSLMTLGAAHGDEVELSADGANAQESVDVL 88
Cdd:TIGR01003  3 SKEVTIINKVGLHARPAAILVKLASGFDSEITLTK-----NGKEVNAKSIMGIMMLGAGQGTEVTVSADGEDEAEALEAL 77


                 ....*
gi 739510088  89 VDLIA 93
Cdd:TIGR01003 78 AKLFE 82
PTS-HPr_Halo NF041319
phosphocarrier protein HPr;
9-92 6.98e-13

phosphocarrier protein HPr;


Pssm-ID: 469216 [Multi-domain]  Cd Length: 87  Bit Score: 58.46  E-value: 6.98e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739510088  9 QRRIVVASRVGLHARPAGLVAQTAAAQPAKVRIAKVSGGaaGDPVDAGSVLSLMTLGAAHGDEVELSADGANAQESVDVL 88
Cdd:NF041319  2 ERTVTVVPEAGLHARPASKFVETANEFDAEVTVGRADDD--GDLVNAASMLAVTGLGVRHGEDVRLVAEGDDAEAALDAL 79


                ....
gi 739510088 89 VDLI 92
Cdd:NF041319 80 EAVL 83
PRK13782 PRK13782
HPr family phosphocarrier protein;
9-92 6.79e-10

HPr family phosphocarrier protein;


Pssm-ID: 172320 [Multi-domain]  Cd Length: 82  Bit Score: 50.94  E-value: 6.79e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739510088  9 QRRIVVASRVGLHARPAGLVAQTAAAQPAKVRIAKvsggaAGDPVDAGSVLSLMTLGAAHGDEVELSADGANAQESVDVL 88
Cdd:PRK13782  3 QKRVEVSLKTGLQARPAALFVQEANRFHADIFIEK-----DGKKVNAKSIMGLMSLAIGTGSMITIITEGSDEEEALEAL 77


                ....
gi 739510088 89 VDLI 92
Cdd:PRK13782 78 AAYV 81
 
Name Accession Description Interval E-value
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 8-97 6.69e-27

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 94.02  E-value: 6.69e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739510088  8 YQRRIVVASRVGLHARPAGLVAQTAAAQPAKVRIAKvsggaAGDPVDAGSVLSLMTLGAAHGDEVELSADGANAQESVDV 87
Cdd:COG1925   2 LEREVTIVNKLGLHARPAAKLVQLASKFDSEITVEK-----GGKEVNAKSIMGLMSLGAKKGDEVTITAEGPDAEEALDA 76

                        90
                ....*....|
gi 739510088 88 LVDLIAKDLD 97
Cdd:COG1925  77 LAALIESGFG 86
PTS-HPr pfam00381
PTS HPr component phosphorylation site;
10-93 1.46e-24

PTS HPr component phosphorylation site;


Pssm-ID: 459792 [Multi-domain]  Cd Length: 79  Bit Score: 87.83  E-value: 1.46e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739510088  10 RRIVVASRVGLHARPAGLVAQTAAAQPAKVRIAKvsggaAGDPVDAGSVLSLMTLGAAHGDEVELSADGANAQESVDVLV 89
Cdd:pfam00381  1 KTVTITNPLGLHARPAALLVQLASKFDSDITLEK-----GGKKVNAKSIMGLMSLGAKQGDEITISAEGEDEEEALEALA 75


                 ....
gi 739510088  90 DLIA 93
Cdd:pfam00381 76 ALLE 79
PTS-HPr_like cd00367
Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of ...
 11-92 1.26e-19

Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate is transferred to HPr by enzyme I (EI). Phospho-HPr then transfers the phosphoryl group to one of several sugar-specific phosphoprotein intermediates. The conserved histidine in the N-terminus of HPr serves as an acceptor for the phosphoryl group of EI. In addition to the phosphotransferase proteins HPr and E1, this family also includes the closely related Carbon Catabolite Repressor (CCR) proteins which use the same phosphorylation mechanism and interact with transcriptional regulators to control expression of genes coding for utilization of less favored carbon sources.


Pssm-ID: 238217 [Multi-domain]  Cd Length: 77  Bit Score: 75.24  E-value: 1.26e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739510088 11 RIVVASRVGLHARPAGLVAQTAAAQPAKVRIAKvsggaAGDPVDAGSVLSLMTLGAAHGDEVELSADGANAQESVDVLVD 90
Cdd:cd00367   1 TVTITNPLGLHARPAALLVQLASKFKSDITLRK-----GGRKANAKSILGLMSLGAKQGDEITLSAEGEDAEEALEALAE 75


                ..
gi 739510088 91 LI 92
Cdd:cd00367  76 LL 77
PTS_HPr_family TIGR01003
Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains ...
 9-93 8.27e-19

Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS]


Pssm-ID: 273389 [Multi-domain]  Cd Length: 82  Bit Score: 73.45  E-value: 8.27e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739510088   9 QRRIVVASRVGLHARPAGLVAQTAAAQPAKVRIAKvsggaAGDPVDAGSVLSLMTLGAAHGDEVELSADGANAQESVDVL 88
Cdd:TIGR01003  3 SKEVTIINKVGLHARPAAILVKLASGFDSEITLTK-----NGKEVNAKSIMGIMMLGAGQGTEVTVSADGEDEAEALEAL 77


                 ....*
gi 739510088  89 VDLIA 93
Cdd:TIGR01003 78 AKLFE 82
PTS-HPr_Halo NF041319
phosphocarrier protein HPr;
9-92 6.98e-13

phosphocarrier protein HPr;


Pssm-ID: 469216 [Multi-domain]  Cd Length: 87  Bit Score: 58.46  E-value: 6.98e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739510088  9 QRRIVVASRVGLHARPAGLVAQTAAAQPAKVRIAKVSGGaaGDPVDAGSVLSLMTLGAAHGDEVELSADGANAQESVDVL 88
Cdd:NF041319  2 ERTVTVVPEAGLHARPASKFVETANEFDAEVTVGRADDD--GDLVNAASMLAVTGLGVRHGEDVRLVAEGDDAEAALDAL 79


                ....
gi 739510088 89 VDLI 92
Cdd:NF041319 80 EAVL 83
PRK13782 PRK13782
HPr family phosphocarrier protein;
9-92 6.79e-10

HPr family phosphocarrier protein;


Pssm-ID: 172320 [Multi-domain]  Cd Length: 82  Bit Score: 50.94  E-value: 6.79e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739510088  9 QRRIVVASRVGLHARPAGLVAQTAAAQPAKVRIAKvsggaAGDPVDAGSVLSLMTLGAAHGDEVELSADGANAQESVDVL 88
Cdd:PRK13782  3 QKRVEVSLKTGLQARPAALFVQEANRFHADIFIEK-----DGKKVNAKSIMGLMSLAIGTGSMITIITEGSDEEEALEAL 77


                ....
gi 739510088 89 VDLI 92
Cdd:PRK13782 78 AAYV 81
PRK10850 PRK10850
phosphocarrier protein Hpr;
7-94 1.08e-09

phosphocarrier protein Hpr;


Pssm-ID: 182777 [Multi-domain]  Cd Length: 85  Bit Score: 50.51  E-value: 1.08e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739510088  7 VYQRRIVVASRVGLHARPAGLVAQTAAAQPAKVRIakVSGGAAGDpvdAGSVLSLMTLGAAHGDEVELSADGANAQESVD 86
Cdd:PRK10850  1 MFQQEVTITAPNGLHTRPAAQFVKEAKGFTSEITV--TSNGKSAS---AKSLFKLQTLGLTQGTVVTISAEGEDEQKAVE 75


                ....*...
gi 739510088 87 VLVDLIAK 94
Cdd:PRK10850 76 HLVKLMAE 83
PRK13780 PRK13780
phosphocarrier protein HPr; Provisional
 9-95 1.18e-09

phosphocarrier protein HPr; Provisional


Pssm-ID: 237503 [Multi-domain]  Cd Length: 88  Bit Score: 50.47  E-value: 1.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739510088  9 QRRIVVASRVGLHARPAGLVAQTAAAQPAKVRIAkvsggAAGDPVDAGSVLSLMTLGAAHGDEVELSADGANAQESVDVL 88
Cdd:PRK13780  3 SKDFHITAETGIHARPATLLVQTASKFDSDITLE-----YNGKSVNLKSIMGVMSLGVGQGADITISAEGADAADAIAAI 77


                ....*..
gi 739510088 89 VDLIAKD 95
Cdd:PRK13780 78 EETMKKE 84
PRK11109 PRK11109
fused PTS fructose transporter subunit IIA/HPr protein;
19-96 3.84e-07

fused PTS fructose transporter subunit IIA/HPr protein;


Pssm-ID: 236849 [Multi-domain]  Cd Length: 375  Bit Score: 46.09  E-value: 3.84e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 739510088  19 GLHARPAGLVAQTAAAQPAKVRIAKVSGgaAGDPVDAGSVLSLMTLGAAHGDEVELSADGANAQESVDVLVDLIAKDL 96
Cdd:PRK11109 297 GLHARPGAMLVNTIKQFNSEITVTNLDG--TGKPANGRSLMKVVALGVKKGHRLRFTAQGEDAEQALKAIGEAIAAGL 372
PRK13779 PRK13779
bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional
 19-96 3.02e-06

bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional


Pssm-ID: 237502 [Multi-domain]  Cd Length: 503  Bit Score: 43.71  E-value: 3.02e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 739510088  19 GLHARPAGLVAQTAAAQPAKVRIAKVSGGAAgdPVDAGSVLSLMTLGAAHGDEVELSADGANAQESVDVLVDLIAKDL 96
Cdd:PRK13779 302 GLHARPSANLVNEVKKFTAKITVENLTRGSA--PVSAKSLMKIVALGVTQGHRLRFVAEGEDAQQAIEALAKAIAEGL 377
PRK10897 PRK10897
PTS phosphocarrier protein NPr;
9-97 8.86e-05

PTS phosphocarrier protein NPr;


Pssm-ID: 182819 [Multi-domain]  Cd Length: 90  Bit Score: 37.88  E-value: 8.86e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739510088  9 QRRIVVASRVGLHARPAGLVAQTAAAQPAKVRIAKVSGGAAgdpvDAGSVLSLMTLGAAHGDEVELSADGANAQESVDVL 88
Cdd:PRK10897  4 KQTVEIKNKLGMHARPAMKLFELVQGFDAEVLLRNDEGTEA----EANSVIALLMLDSAKGRQIEVEATGPQEEEALAAV 79


                ....*....
gi 739510088 89 VDLIAKDLD 97
Cdd:PRK10897 80 IALFNSGFD 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH