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Conserved domains on  [gi|739564140|ref|WP_037422272|]
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MULTISPECIES: 3-deoxy-8-phosphooctulonate synthase [Shewanella]

Protein Classification

3-deoxy-8-phosphooctulonate synthase( domain architecture ID 10012268)

3-deoxy-8-phosphooctulonate synthase catalyzes the condensation reaction between arabinose 5-phosphate and phosphoenolpyruvate to synthesize 3-deoxy-D-manno-octulosonate-8-phosphate (KDO8P), the precursor of the 8-carbon sugar KDO, which is an essential component of gram-negative bacterial lipopolysaccharides

Gene Ontology:  GO:0019294|GO:0008676
SCOP:  4003245

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK05198 PRK05198
2-dehydro-3-deoxyphosphooctonate aldolase; Provisional
 9-272 0e+00

2-dehydro-3-deoxyphosphooctonate aldolase; Provisional


:

Pssm-ID: 235363  Cd Length: 264  Bit Score: 541.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140   9 GSIEIANDKPFVLFGGMNVLESRDLAMSIAETYAEVTQKLGIPYVFKASFDKANRSSVNSYRGPGMEEGLKIFEEIKKTF 88
Cdd:PRK05198   1 GDIEVGNDLPFFLIAGPCVIESRDLALRIAEHLKEITDKLGIPYVFKASFDKANRSSIHSFRGPGLEEGLKILQEVKETF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140  89 NLPLITDVHEPYQCAPVAEVVDIIQLPAFLARQTDLVVAMAKTGAIINVKKPQFLAPHEMRHIITKFNEAGNDEIILCER 168
Cdd:PRK05198  81 GVPVLTDVHEPEQAAPVAEVVDVLQIPAFLCRQTDLLVAAAKTGKVVNIKKGQFLAPWDMKNVVDKVREAGNDKIILCER 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140 169 GSCFGYNNLVVDMLGMDEMKQSGYPVIFDATHALQRPGGRADSAGGRRAQATELARSGMALGLAGLFIEAHPDPDNAKCD 248
Cdd:PRK05198 161 GTSFGYNNLVVDMRGLPIMRETGAPVIFDATHSVQLPGGQGGSSGGQREFVPVLARAAVAVGVAGLFIETHPDPDNALSD 240

                        250       260
                 ....*....|....*....|....
gi 739564140 249 GPCALPLHQLENYLKQMKAMDDLV 272
Cdd:PRK05198 241 GPNMLPLDKLEPLLEQLKAIDDLV 264
 
Name Accession Description Interval E-value
PRK05198 PRK05198
2-dehydro-3-deoxyphosphooctonate aldolase; Provisional
 9-272 0e+00

2-dehydro-3-deoxyphosphooctonate aldolase; Provisional


Pssm-ID: 235363  Cd Length: 264  Bit Score: 541.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140   9 GSIEIANDKPFVLFGGMNVLESRDLAMSIAETYAEVTQKLGIPYVFKASFDKANRSSVNSYRGPGMEEGLKIFEEIKKTF 88
Cdd:PRK05198   1 GDIEVGNDLPFFLIAGPCVIESRDLALRIAEHLKEITDKLGIPYVFKASFDKANRSSIHSFRGPGLEEGLKILQEVKETF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140  89 NLPLITDVHEPYQCAPVAEVVDIIQLPAFLARQTDLVVAMAKTGAIINVKKPQFLAPHEMRHIITKFNEAGNDEIILCER 168
Cdd:PRK05198  81 GVPVLTDVHEPEQAAPVAEVVDVLQIPAFLCRQTDLLVAAAKTGKVVNIKKGQFLAPWDMKNVVDKVREAGNDKIILCER 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140 169 GSCFGYNNLVVDMLGMDEMKQSGYPVIFDATHALQRPGGRADSAGGRRAQATELARSGMALGLAGLFIEAHPDPDNAKCD 248
Cdd:PRK05198 161 GTSFGYNNLVVDMRGLPIMRETGAPVIFDATHSVQLPGGQGGSSGGQREFVPVLARAAVAVGVAGLFIETHPDPDNALSD 240

                        250       260
                 ....*....|....*....|....
gi 739564140 249 GPCALPLHQLENYLKQMKAMDDLV 272
Cdd:PRK05198 241 GPNMLPLDKLEPLLEQLKAIDDLV 264
KdsA COG2877
3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell wall/membrane/envelope ...
 8-272 0e+00

3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell wall/membrane/envelope biogenesis]; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase is part of the Pathway/BioSystem: Lipid A biosynthesis


Pssm-ID: 442124  Cd Length: 265  Bit Score: 535.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140   8 LGSIEIANDKPFVLFGGMNVLESRDLAMSIAETYAEVTQKLGIPYVFKASFDKANRSSVNSYRGPGMEEGLKIFEEIKKT 87
Cdd:COG2877    1 IGGIEVGNDKPLFLIAGPCVIESEDLALEIAEKLKEITDKLGIPYIFKASFDKANRSSIDSFRGPGLEEGLKILAEVKEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140  88 FNLPLITDVHEPYQCAPVAEVVDIIQLPAFLARQTDLVVAMAKTGAIINVKKPQFLAPHEMRHIITKFNEAGNDEIILCE 167
Cdd:COG2877   81 FGVPVLTDVHEPEQAAPVAEVVDVLQIPAFLCRQTDLLVAAAKTGKVVNVKKGQFLAPWDMKNVVEKVREAGNDNILLTE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140 168 RGSCFGYNNLVVDMLGMDEMKQSGYPVIFDATHALQRPGGRADSAGGRRAQATELARSGMALGLAGLFIEAHPDPDNAKC 247
Cdd:COG2877  161 RGTSFGYNNLVVDMRSLPIMRETGYPVVFDATHSVQLPGGQGGSSGGQREFVPVLARAAVAVGVDGLFMETHPDPDKALS 240

                        250       260
                 ....*....|....*....|....*
gi 739564140 248 DGPCALPLHQLENYLKQMKAMDDLV 272
Cdd:COG2877  241 DGPNMLPLDKLEELLEQLKAIDELV 265
KDO8P_synth TIGR01362
3-deoxy-8-phosphooctulonate synthase; This model describes 3-deoxy-8-phosphooctulonate ...
 17-274 2.20e-158

3-deoxy-8-phosphooctulonate synthase; This model describes 3-deoxy-8-phosphooctulonate synthase. Alternate names include 2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-d-manno-octulosonic acid 8-phosphate and KDO-8 phosphate synthetase. It catalyzes the aldol condensation of phosphoenolpyruvate with D-arabinose 5-phosphate: phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate In Gram-negative bacteria, this is the first step in the biosynthesis of 3-deoxy-D-manno-octulosonate, part of the oligosaccharide core of lipopolysaccharide. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 130429  Cd Length: 258  Bit Score: 441.03  E-value: 2.20e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140   17 KPFVLFGGMNVLESRDLAMSIAETYAEVTQKLGIPYVFKASFDKANRSSVNSYRGPGMEEGLKIFEEIKKTFNLPLITDV 96
Cdd:TIGR01362   1 EKFFLIAGPCVIESEDHALRVAEKLKELTSKLGVPFIFKSSFDKANRSSIHSFRGPGLEEGLKILQKVKEEFGVPILTDV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140   97 HEPYQCAPVAEVVDIIQLPAFLARQTDLVVAMAKTGAIINVKKPQFLAPHEMRHIITKFNEAGNDEIILCERGSCFGYNN 176
Cdd:TIGR01362  81 HESSQCEPVAEVVDIIQIPAFLCRQTDLLVAAAKTGRIVNVKKGQFLSPWDMKNVVEKVLSTGNKNILLCERGTSFGYNN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140  177 LVVDMLGMDEMKQSGYPVIFDATHALQRPGGRADSAGGRRAQATELARSGMALGLAGLFIEAHPDPDNAKCDGPCALPLH 256
Cdd:TIGR01362 161 LVVDMRSLPIMRELGCPVIFDATHSVQQPGGLGGASGGLREFVPTLARAAVAVGIDGLFMETHPDPKNAKSDGPNMLPLS 240

                         250
                  ....*....|....*...
gi 739564140  257 QLENYLKQMKAMDDLVKS 274
Cdd:TIGR01362 241 ELEGLLEKLLAIDALTKS 258
DAHP_synth_1 pfam00793
DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino ...
 11-274 3.91e-90

DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino acid biosynthesis from chorismate. E-coli has three related synthetases, which are inhibited by different aromatic amino acids. This family also includes KDSA which has very similar catalytic activity but is involved in the first step of liposaccharide biosynthesis. The enzyme is also part of the shikimate pathway, EC:2.5.1.54.


Pssm-ID: 395641  Cd Length: 271  Bit Score: 268.42  E-value: 3.91e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140   11 IEIANDKPFVLFGGMNVLESRDLAMSIAETYAEVTQKLGIPYVFKASFDKANRSsVNSYRGPGMEEGLKIFEEIKKTFNL 90
Cdd:pfam00793  10 IIIGKDDRLLVIAGPCSIEDPEAAMEYARRLKKLGAKLKLIIIMRAYFEKPRTS-PVGFKGLGNDPDLNILFRIKDGLGL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140   91 PLITDVHEPYQCAPVAEVVDIIQLPAFLARQTDLVVAMAKTGAIINVKKPQFLAPHEMRHIITKFNEAG-NDEIILCERG 169
Cdd:pfam00793  89 PIATEVLDPIDPQYLADVVDIGQIGARTTESQDLLELAGGLSKPVGFKNGTDAAIDEMLAAAEYHLFLGvTKGNILCERG 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140  170 SCFGY--NNLVVDMLGMDEMKQSGY--PVIFDATHALQRPGgradsaGGRRAQATELARSGMALGLAGLFIEAHPDPDNA 245
Cdd:pfam00793 169 IRGGEgpNRNTLDVSAVAILKEETGhlPVMVDVSHANGRKD------GGRQPLVLPLAKAAIAVGIDGLMIEVHPNPGNA 242

                         250       260
                  ....*....|....*....|....*....
gi 739564140  246 KCDGPCALPLHQLENYLKQMKAMDDLVKS 274
Cdd:pfam00793 243 LSDGPQQLKYGKSETDACILWELTELLLE 271
BagF_FevY NF041229
phospho-2-dehydro-3-deoxyheptonate aldolase BagF/FevY;
63-266 2.19e-21

phospho-2-dehydro-3-deoxyheptonate aldolase BagF/FevY;


Pssm-ID: 469132 [Multi-domain]  Cd Length: 340  Bit Score: 92.02  E-value: 2.19e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140  63 RSSVNSYRGPGmEEGLKIFEEIKKTFNLPLITDVHEPYQCAPVAEVVDIIQLPAFLARQTDLVVAMAKTGAIINVKKPQF 142
Cdd:NF041229 129 RTSPYAFQGLG-EAGLKILADVRAETGLPIVTEVVDAHDVELVASYADMLQIGTRNAQNFALLQAVGDVGKPVMLKRGMS 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140 143 LAPHEMRHIITKFNEAGNDEIILCERG----SCFGYNNLVVDMLGMDEmKQSGYPVIFDATHAlqrpggradsaGGRRAQ 218
Cdd:NF041229 208 GTIEEWLMAAEYVAQRGNLDIVLCERGirtfETATRNTLDIAAVPIVQ-RLSHLPVIVDPSHS-----------GGRRDL 275

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 739564140 219 ATELARSGMALGLAGLFIEAHPDPDNAKCDGPCALPLHQLENYLKQMK 266
Cdd:NF041229 276 VLPLTRAALAVGADGVIVDVHPDPRTALCDGPQALVHEDLEELGAVMR 323
 
Name Accession Description Interval E-value
PRK05198 PRK05198
2-dehydro-3-deoxyphosphooctonate aldolase; Provisional
 9-272 0e+00

2-dehydro-3-deoxyphosphooctonate aldolase; Provisional


Pssm-ID: 235363  Cd Length: 264  Bit Score: 541.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140   9 GSIEIANDKPFVLFGGMNVLESRDLAMSIAETYAEVTQKLGIPYVFKASFDKANRSSVNSYRGPGMEEGLKIFEEIKKTF 88
Cdd:PRK05198   1 GDIEVGNDLPFFLIAGPCVIESRDLALRIAEHLKEITDKLGIPYVFKASFDKANRSSIHSFRGPGLEEGLKILQEVKETF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140  89 NLPLITDVHEPYQCAPVAEVVDIIQLPAFLARQTDLVVAMAKTGAIINVKKPQFLAPHEMRHIITKFNEAGNDEIILCER 168
Cdd:PRK05198  81 GVPVLTDVHEPEQAAPVAEVVDVLQIPAFLCRQTDLLVAAAKTGKVVNIKKGQFLAPWDMKNVVDKVREAGNDKIILCER 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140 169 GSCFGYNNLVVDMLGMDEMKQSGYPVIFDATHALQRPGGRADSAGGRRAQATELARSGMALGLAGLFIEAHPDPDNAKCD 248
Cdd:PRK05198 161 GTSFGYNNLVVDMRGLPIMRETGAPVIFDATHSVQLPGGQGGSSGGQREFVPVLARAAVAVGVAGLFIETHPDPDNALSD 240

                        250       260
                 ....*....|....*....|....
gi 739564140 249 GPCALPLHQLENYLKQMKAMDDLV 272
Cdd:PRK05198 241 GPNMLPLDKLEPLLEQLKAIDDLV 264
KdsA COG2877
3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell wall/membrane/envelope ...
 8-272 0e+00

3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell wall/membrane/envelope biogenesis]; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase is part of the Pathway/BioSystem: Lipid A biosynthesis


Pssm-ID: 442124  Cd Length: 265  Bit Score: 535.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140   8 LGSIEIANDKPFVLFGGMNVLESRDLAMSIAETYAEVTQKLGIPYVFKASFDKANRSSVNSYRGPGMEEGLKIFEEIKKT 87
Cdd:COG2877    1 IGGIEVGNDKPLFLIAGPCVIESEDLALEIAEKLKEITDKLGIPYIFKASFDKANRSSIDSFRGPGLEEGLKILAEVKEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140  88 FNLPLITDVHEPYQCAPVAEVVDIIQLPAFLARQTDLVVAMAKTGAIINVKKPQFLAPHEMRHIITKFNEAGNDEIILCE 167
Cdd:COG2877   81 FGVPVLTDVHEPEQAAPVAEVVDVLQIPAFLCRQTDLLVAAAKTGKVVNVKKGQFLAPWDMKNVVEKVREAGNDNILLTE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140 168 RGSCFGYNNLVVDMLGMDEMKQSGYPVIFDATHALQRPGGRADSAGGRRAQATELARSGMALGLAGLFIEAHPDPDNAKC 247
Cdd:COG2877  161 RGTSFGYNNLVVDMRSLPIMRETGYPVVFDATHSVQLPGGQGGSSGGQREFVPVLARAAVAVGVDGLFMETHPDPDKALS 240

                        250       260
                 ....*....|....*....|....*
gi 739564140 248 DGPCALPLHQLENYLKQMKAMDDLV 272
Cdd:COG2877  241 DGPNMLPLDKLEELLEQLKAIDELV 265
PRK12457 PRK12457
3-deoxy-8-phosphooctulonate synthase;
5-279 1.50e-172

3-deoxy-8-phosphooctulonate synthase;


Pssm-ID: 237105  Cd Length: 281  Bit Score: 477.70  E-value: 1.50e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140   5 IIKLGSIEIANDKPFVLFGGMNVLESRDLAMSIAETYAEVTQKLGIPYVFKASFDKANRSSVNSYRGPGMEEGLKIFEEI 84
Cdd:PRK12457   3 VAISPGITVGNDLPFVLFGGINVLESLDFTLDVCGEYVEVTRKLGIPFVFKASFDKANRSSIHSYRGVGLDEGLRIFEEV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140  85 KKTFNLPLITDVHEPYQCAPVAEVVDIIQLPAFLARQTDLVVAMAKTGAIINVKKPQFLAPHEMRHIITKFNEAGNDEII 164
Cdd:PRK12457  83 KARFGVPVITDVHEVEQAAPVAEVADVLQVPAFLARQTDLVVAIAKTGKPVNIKKPQFMSPTQMKHVVSKCREAGNDRVI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140 165 LCERGSCFGYNNLVVDMLGMDEMKQ--SGYPVIFDATHALQR--PGGRAdsAGGRRAQATELARSGMALGLAGLFIEAHP 240
Cdd:PRK12457 163 LCERGSSFGYDNLVVDMLGFRQMKRttGDLPVIFDVTHSLQCrdPLGAA--SGGRRRQVLDLARAGMAVGLAGLFLEAHP 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 739564140 241 DPDNAKCDGPCALPLHQLENYLKQMKAMDDLVKSFEPID 279
Cdd:PRK12457 241 DPDRARCDGPSALPLDQLEPFLSQVKALDDLVKSFPPLD 279
KDO8P_synth TIGR01362
3-deoxy-8-phosphooctulonate synthase; This model describes 3-deoxy-8-phosphooctulonate ...
 17-274 2.20e-158

3-deoxy-8-phosphooctulonate synthase; This model describes 3-deoxy-8-phosphooctulonate synthase. Alternate names include 2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-d-manno-octulosonic acid 8-phosphate and KDO-8 phosphate synthetase. It catalyzes the aldol condensation of phosphoenolpyruvate with D-arabinose 5-phosphate: phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate In Gram-negative bacteria, this is the first step in the biosynthesis of 3-deoxy-D-manno-octulosonate, part of the oligosaccharide core of lipopolysaccharide. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 130429  Cd Length: 258  Bit Score: 441.03  E-value: 2.20e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140   17 KPFVLFGGMNVLESRDLAMSIAETYAEVTQKLGIPYVFKASFDKANRSSVNSYRGPGMEEGLKIFEEIKKTFNLPLITDV 96
Cdd:TIGR01362   1 EKFFLIAGPCVIESEDHALRVAEKLKELTSKLGVPFIFKSSFDKANRSSIHSFRGPGLEEGLKILQKVKEEFGVPILTDV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140   97 HEPYQCAPVAEVVDIIQLPAFLARQTDLVVAMAKTGAIINVKKPQFLAPHEMRHIITKFNEAGNDEIILCERGSCFGYNN 176
Cdd:TIGR01362  81 HESSQCEPVAEVVDIIQIPAFLCRQTDLLVAAAKTGRIVNVKKGQFLSPWDMKNVVEKVLSTGNKNILLCERGTSFGYNN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140  177 LVVDMLGMDEMKQSGYPVIFDATHALQRPGGRADSAGGRRAQATELARSGMALGLAGLFIEAHPDPDNAKCDGPCALPLH 256
Cdd:TIGR01362 161 LVVDMRSLPIMRELGCPVIFDATHSVQQPGGLGGASGGLREFVPTLARAAVAVGIDGLFMETHPDPKNAKSDGPNMLPLS 240

                         250
                  ....*....|....*...
gi 739564140  257 QLENYLKQMKAMDDLVKS 274
Cdd:TIGR01362 241 ELEGLLEKLLAIDALTKS 258
PLN03033 PLN03033
2-dehydro-3-deoxyphosphooctonate aldolase; Provisional
 12-278 9.07e-101

2-dehydro-3-deoxyphosphooctonate aldolase; Provisional


Pssm-ID: 178601  Cd Length: 290  Bit Score: 296.39  E-value: 9.07e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140  12 EIANDKPFVLFGGMNVLESRDLAMSIAETYAEVTQKLGIPYVFKASFDKANRSSVNSYRGPGMEEGLKIFEEIKKTFNLP 91
Cdd:PLN03033  10 QLKAAEPFFLLAGPNVIESEEHILRMAKHIKDISTKLGLPLVFKSSFDKANRTSSKSFRGPGMAEGLKILEKVKVAYDLP 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140  92 LITDVHEPYQCAPVAEVVDIIQLPAFLARQTDLVVAMAKTGAIINVKKPQFLAPHEMRHIITKFNEAGNDEIILCERGSC 171
Cdd:PLN03033  90 IVTDVHESSQCEAVGKVADIIQIPAFLCRQTDLLVAAAKTGKIINIKKGQFCAPSVMRNSAEKVRLAGNPNVMVCERGTM 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140 172 FGYNNLVVDMLGMDEMKQSGYPVIFDATHALQRPGGRAD-----SAGGRRAQATELARSGMALGLAGLFIEAHPDPDNAK 246
Cdd:PLN03033 170 FGYNDLIVDPRNLEWMREANCPVVADITHSLQQPAGKKLdgggvASGGLRELIPCIARTAVAVGVDGIFMEVHDDPLSAP 249

                        250       260       270
                 ....*....|....*....|....*....|..
gi 739564140 247 CDGPCALPLHQLENYLKQMKAMDDLVKSFEPI 278
Cdd:PLN03033 250 VDGPTQWPLRHLEELLEELIAIARVTKGKQRF 281
DAHP_synth_1 pfam00793
DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino ...
 11-274 3.91e-90

DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino acid biosynthesis from chorismate. E-coli has three related synthetases, which are inhibited by different aromatic amino acids. This family also includes KDSA which has very similar catalytic activity but is involved in the first step of liposaccharide biosynthesis. The enzyme is also part of the shikimate pathway, EC:2.5.1.54.


Pssm-ID: 395641  Cd Length: 271  Bit Score: 268.42  E-value: 3.91e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140   11 IEIANDKPFVLFGGMNVLESRDLAMSIAETYAEVTQKLGIPYVFKASFDKANRSsVNSYRGPGMEEGLKIFEEIKKTFNL 90
Cdd:pfam00793  10 IIIGKDDRLLVIAGPCSIEDPEAAMEYARRLKKLGAKLKLIIIMRAYFEKPRTS-PVGFKGLGNDPDLNILFRIKDGLGL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140   91 PLITDVHEPYQCAPVAEVVDIIQLPAFLARQTDLVVAMAKTGAIINVKKPQFLAPHEMRHIITKFNEAG-NDEIILCERG 169
Cdd:pfam00793  89 PIATEVLDPIDPQYLADVVDIGQIGARTTESQDLLELAGGLSKPVGFKNGTDAAIDEMLAAAEYHLFLGvTKGNILCERG 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140  170 SCFGY--NNLVVDMLGMDEMKQSGY--PVIFDATHALQRPGgradsaGGRRAQATELARSGMALGLAGLFIEAHPDPDNA 245
Cdd:pfam00793 169 IRGGEgpNRNTLDVSAVAILKEETGhlPVMVDVSHANGRKD------GGRQPLVLPLAKAAIAVGIDGLMIEVHPNPGNA 242

                         250       260
                  ....*....|....*....|....*....
gi 739564140  246 KCDGPCALPLHQLENYLKQMKAMDDLVKS 274
Cdd:pfam00793 243 LSDGPQQLKYGKSETDACILWELTELLLE 271
PRK08673 PRK08673
3-deoxy-7-phosphoheptulonate synthase; Reviewed
 1-273 8.31e-32

3-deoxy-7-phosphoheptulonate synthase; Reviewed


Pssm-ID: 181535 [Multi-domain]  Cd Length: 335  Bit Score: 120.00  E-value: 8.31e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140   1 MSNKIIKLGSIEIANDKPFVLFGGMNVlESRDLAMSIAETYAEVTQKL---GIpyvFKAsfdkanRSSVNSYRGPGmEEG 77
Cdd:PRK08673  77 PEPTVVKVGDVEIGGGKPVVIAGPCSV-ESEEQILEIARAVKEAGAQIlrgGA---FKP------RTSPYSFQGLG-EEG 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140  78 LKIFEEIKKTFNLPLITDVHEPYQCAPVAEVVDIIQLPAFLARQTDLVVAMAKTgaiinvKKPQFLAPHeMRHIITKFNE 157
Cdd:PRK08673 146 LKLLAEAREETGLPIVTEVMDPRDVELVAEYVDILQIGARNMQNFDLLKEVGKT------NKPVLLKRG-MSATIEEWLM 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140 158 A-------GNDEIILCERG----SCFGYNNLvvDMLGMDEMKQ-SGYPVIFDATHalqrpggradsAGGRRAQATELARS 225
Cdd:PRK08673 219 AaeyilaeGNPNVILCERGirtfETATRNTL--DLSAVPVIKKlTHLPVIVDPSH-----------ATGKRDLVEPLALA 285

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 739564140 226 GMALGLAGLFIEAHPDPDNAKCDGPCALPLHQLENYLKQMKAMDDLVK 273
Cdd:PRK08673 286 AVAAGADGLIVEVHPDPEKALSDGPQSLTPEEFEELMKKLRAIAEALG 333
AroGA COG2876
3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and ...
 5-272 1.52e-28

3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 442123  Cd Length: 283  Bit Score: 110.16  E-value: 1.52e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140   5 IIKLGSIEIANDKpFVLFGGMNVLESRDLAMSIAETYAEVTQKL---GipyVFKAsfdkanRSSVNSYRGPGmEEGLKIF 81
Cdd:COG2876   28 VVDVGGVKIGGGE-LVVIAGPCAVESEEQILETAKAVKAAGAKIlrgG---AFKP------RTSPYSFQGLG-EEGLKLL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140  82 EEIKKTFNLPLITDVHEPYQCAPVAEVVDIIQLPAflaR--Q-TDLVVAMAKTGaiinvkKPQFLapheMRHIITKFNE- 157
Cdd:COG2876   97 AEAREETGLPVVTEVMDPRDVELVAEYADILQIGA---RnmQnFELLKEVGRTG------KPVLL----KRGLSATIEEw 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140 158 ---------AGNDEIILCERGS-CFG--YNNlVVDMLGMDEMKQ-SGYPVIFDATHAlqrpggradsaGGRRAQATELAR 224
Cdd:COG2876  164 lmaaeyilsEGNPNVILCERGIrTFEtaTRN-TLDLSAVPVLKElTHLPVIVDPSHA-----------TGRRDLVPPMAK 231

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 739564140 225 SGMALGLAGLFIEAHPDPDNAKCDGPCALPLHQLENYLKQMKAMDDLV 272
Cdd:COG2876  232 AAVAAGADGLMIEVHPDPEKALSDGPQSLTPEEFAELMEELRKLAEAV 279
BagF_FevY NF041229
phospho-2-dehydro-3-deoxyheptonate aldolase BagF/FevY;
63-266 2.19e-21

phospho-2-dehydro-3-deoxyheptonate aldolase BagF/FevY;


Pssm-ID: 469132 [Multi-domain]  Cd Length: 340  Bit Score: 92.02  E-value: 2.19e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140  63 RSSVNSYRGPGmEEGLKIFEEIKKTFNLPLITDVHEPYQCAPVAEVVDIIQLPAFLARQTDLVVAMAKTGAIINVKKPQF 142
Cdd:NF041229 129 RTSPYAFQGLG-EAGLKILADVRAETGLPIVTEVVDAHDVELVASYADMLQIGTRNAQNFALLQAVGDVGKPVMLKRGMS 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140 143 LAPHEMRHIITKFNEAGNDEIILCERG----SCFGYNNLVVDMLGMDEmKQSGYPVIFDATHAlqrpggradsaGGRRAQ 218
Cdd:NF041229 208 GTIEEWLMAAEYVAQRGNLDIVLCERGirtfETATRNTLDIAAVPIVQ-RLSHLPVIVDPSHS-----------GGRRDL 275

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 739564140 219 ATELARSGMALGLAGLFIEAHPDPDNAKCDGPCALPLHQLENYLKQMK 266
Cdd:NF041229 276 VLPLTRAALAVGADGVIVDVHPDPRTALCDGPQALVHEDLEELGAVMR 323
PRK12595 PRK12595
bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed
 3-274 5.21e-18

bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed


Pssm-ID: 183614 [Multi-domain]  Cd Length: 360  Bit Score: 82.72  E-value: 5.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140   3 NKIIKLGSIEIANDKPFVLFGGMNVlESRDLAMSIAETYAEVTQKLGIPYVFKAsfdkanRSSVNSYRGPGmEEGLKIFE 82
Cdd:PRK12595 104 DTIVDVKGEVIGDGNQSFIFGPCSV-ESYEQVEAVAKALKAKGLKLLRGGAFKP------RTSPYDFQGLG-VEGLKILK 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140  83 EIKKTFNLPLITDVHEPYQCAPVAEVVDIIQLPAFLARQTDLVVAMAKTGAIINVKK------PQFLAPHEmrHIITKfn 156
Cdd:PRK12595 176 QVADEYGLAVISEIVNPADVEVALDYVDVIQIGARNMQNFELLKAAGRVNKPVLLKRglsatiEEFIYAAE--YIMSQ-- 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140 157 eaGNDEIILCERGsCFGY-----NNLvvDMLGMDEMKQSGY-PVIFDATHALqrpggradsagGRRAQATELARSGMALG 230
Cdd:PRK12595 252 --GNGQIILCERG-IRTYekatrNTL--DISAVPILKQETHlPVMVDVTHST-----------GRRDLLLPTAKAALAIG 315

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 739564140 231 LAGLFIEAHPDPDNAKCDGPCALPLHQLENYLKQMKAMDDLVKS 274
Cdd:PRK12595 316 ADGVMAEVHPDPAVALSDSAQQMDIPEFDRFLDELKPLANKLNA 359
PRK13396 PRK13396
3-deoxy-7-phosphoheptulonate synthase; Provisional
 63-273 1.15e-08

3-deoxy-7-phosphoheptulonate synthase; Provisional


Pssm-ID: 237376 [Multi-domain]  Cd Length: 352  Bit Score: 55.15  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140  63 RSSVNSYRGPGmEEGLKIFEEIKKTFNLPLITDVHEPYQCAPVAEVVDIIQLPAflaRQTDLVVAMAKTGAiinVKKPQF 142
Cdd:PRK13396 140 RTSPYAFQGHG-ESALELLAAAREATGLGIITEVMDAADLEKIAEVADVIQVGA---RNMQNFSLLKKVGA---QDKPVL 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739564140 143 LAphemRHIITKFNE----------AGNDEIILCERG-----SCFGYNNL---VVDMLgmdeMKQSGYPVIFDATHALqr 204
Cdd:PRK13396 213 LK----RGMAATIDEwlmaaeyilaAGNPNVILCERGirtfdRQYTRNTLdlsVIPVL----RSLTHLPIMIDPSHGT-- 282

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 739564140 205 pggradsagGRRAQATELARSGMALGLAGLFIEAHPDPDNAKCDGPCALPLHQLENYLKQMKAMDDLVK 273
Cdd:PRK13396 283 ---------GKSEYVPSMAMAAIAAGTDSLMIEVHPNPAKALSDGPQSLTPDRFDRLMQELAVIGKTVG 342
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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