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Conserved domains on  [gi|739622893|ref|WP_037479378|]
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glycosyltransferase family 4 protein [Sphingomonas sp. PAMC 26617]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10133453)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  12691742|10521532|16037492
SCOP:  3001586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 11-351 1.53e-21

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


:

Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 94.53  E-value: 1.53e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893  11 TLVCPARDLRPPADWLACCDDRLTILNVGPLSRGVVLRIPRIAALLWRVigqhEIVHtglAGWPFPLGWIAAPIARIRRR 90
Cdd:cd03801   35 TVLTPADPGEPPEELEDGVIVPLLPSLAALLRARRLLRELRPLLRLRKF----DVVH---AHGLLAALLAALLALLLGAP 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893  91 FLVIVVESSFWRVVPGTAGVAARLKARVFEAANrlcvtwAAATFFTTDAYAAELGKgaRGYKSVSPAT----WIDDATIL 166
Cdd:cd03801  108 LVVTLHGAEPGRLLLLLAAERRLLARAEALLRR------ADAVIAVSEALRDELRA--LGGIPPEKIVvipnGVDLERFS 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 167 SRETILARQKRPDARLLFVGRLSSAKGIDVLLSAIAQ-----SDVVVDILG-EGDRRADCLAIAEQFPERVRLLESIPYG 240
Cdd:cd03801  180 PPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKllrrgPDVRLVIVGgDGPLRAELEELELGLGDRVRFLGFVPDE 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 241 --PGFFETLDrytALVVPTLSDEQPRIIADAFARGVPVIASATTGNCGFVTRDHSGWLVPTGDSRSLAAAMTHALADPDC 318
Cdd:cd03801  260 elPALYAAAD---VFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPPDDVEALADALLRLLADPEL 336

                        330       340       350
                 ....*....|....*....|....*....|...
gi 739622893 319 ALQYGLNARDRIATHtHSAmhERRAEEIDREFR 351
Cdd:cd03801  337 RARLGRAARERVAER-FSW--ERVAERLLDLYR 366
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 11-351 1.53e-21

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 94.53  E-value: 1.53e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893  11 TLVCPARDLRPPADWLACCDDRLTILNVGPLSRGVVLRIPRIAALLWRVigqhEIVHtglAGWPFPLGWIAAPIARIRRR 90
Cdd:cd03801   35 TVLTPADPGEPPEELEDGVIVPLLPSLAALLRARRLLRELRPLLRLRKF----DVVH---AHGLLAALLAALLALLLGAP 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893  91 FLVIVVESSFWRVVPGTAGVAARLKARVFEAANrlcvtwAAATFFTTDAYAAELGKgaRGYKSVSPAT----WIDDATIL 166
Cdd:cd03801  108 LVVTLHGAEPGRLLLLLAAERRLLARAEALLRR------ADAVIAVSEALRDELRA--LGGIPPEKIVvipnGVDLERFS 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 167 SRETILARQKRPDARLLFVGRLSSAKGIDVLLSAIAQ-----SDVVVDILG-EGDRRADCLAIAEQFPERVRLLESIPYG 240
Cdd:cd03801  180 PPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKllrrgPDVRLVIVGgDGPLRAELEELELGLGDRVRFLGFVPDE 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 241 --PGFFETLDrytALVVPTLSDEQPRIIADAFARGVPVIASATTGNCGFVTRDHSGWLVPTGDSRSLAAAMTHALADPDC 318
Cdd:cd03801  260 elPALYAAAD---VFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPPDDVEALADALLRLLADPEL 336

                        330       340       350
                 ....*....|....*....|....*....|...
gi 739622893 319 ALQYGLNARDRIATHtHSAmhERRAEEIDREFR 351
Cdd:cd03801  337 RARLGRAARERVAER-FSW--ERVAERLLDLYR 366
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 182-329 1.23e-18

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 81.94  E-value: 1.23e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893  182 LLFVGRLSSAKGIDVLLSAIAQ-----SDVVVDILGEGDR--RADCLAIAEQFPERVRLLESIPYG--PGFFETLDrytA 252
Cdd:pfam00534   5 ILFVGRLEPEKGLDLLIKAFALlkeknPNLKLVIAGDGEEekRLKKLAEKLGLGDNVIFLGFVSDEdlPELLKIAD---V 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 739622893  253 LVVPTLSDEQPRIIADAFARGVPVIASATTGNCGFVTRDHSGWLVPTGDSRSLAAAMTHALADPDCALQYGLNARDR 329
Cdd:pfam00534  82 FVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPNNAEALAEAIDKLLEDEELRERLGENARKR 158
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 252-346 9.34e-14

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 67.32  E-value: 9.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 252 ALVVPTLSDEQPRIIADAFARGVPVIASATTGNCGFVTRDHSGWLVPTGDSRSLAAAMTHALADPDCALQYGLNARDRIA 331
Cdd:COG0438   23 VFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGDPEALAEAILRLLEDPELRRRLGEAARERAE 102

                         90
                 ....*....|....*
gi 739622893 332 THTHSAMHERRAEEI 346
Cdd:COG0438  103 ERFSWEAIAERLLAL 117
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
182-333 4.43e-05

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 45.17  E-value: 4.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 182 LLFVGRLSSAKGIDVLLSAI-----AQSDVVVDILGE------GDRRA---DCLAIAEQFPERVRLLESIPygPgffETL 247
Cdd:PRK15484 196 LLYAGRISPDKGILLLMQAFeklatAHSNLKLVVVGDptasskGEKAAyqkKVLEAAKRIGDRCIMLGGQP--P---EKM 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 248 DRYTAL----VVPTLSDEQPRIIA-DAFARGVPVIASATTGNCGFVTRDHSGW-LVPTGDSRSLAAAMTHALADPDCAlQ 321
Cdd:PRK15484 271 HNYYPLadlvVVPSQVEEAFCMVAvEAMAAGKPVLASTKGGITEFVLEGITGYhLAEPMTSDSIISDINRTLADPELT-Q 349

                        170
                 ....*....|..
gi 739622893 322 YGLNARDRIATH 333
Cdd:PRK15484 350 IAEQAKDFVFSK 361
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 11-351 1.53e-21

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 94.53  E-value: 1.53e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893  11 TLVCPARDLRPPADWLACCDDRLTILNVGPLSRGVVLRIPRIAALLWRVigqhEIVHtglAGWPFPLGWIAAPIARIRRR 90
Cdd:cd03801   35 TVLTPADPGEPPEELEDGVIVPLLPSLAALLRARRLLRELRPLLRLRKF----DVVH---AHGLLAALLAALLALLLGAP 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893  91 FLVIVVESSFWRVVPGTAGVAARLKARVFEAANrlcvtwAAATFFTTDAYAAELGKgaRGYKSVSPAT----WIDDATIL 166
Cdd:cd03801  108 LVVTLHGAEPGRLLLLLAAERRLLARAEALLRR------ADAVIAVSEALRDELRA--LGGIPPEKIVvipnGVDLERFS 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 167 SRETILARQKRPDARLLFVGRLSSAKGIDVLLSAIAQ-----SDVVVDILG-EGDRRADCLAIAEQFPERVRLLESIPYG 240
Cdd:cd03801  180 PPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKllrrgPDVRLVIVGgDGPLRAELEELELGLGDRVRFLGFVPDE 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 241 --PGFFETLDrytALVVPTLSDEQPRIIADAFARGVPVIASATTGNCGFVTRDHSGWLVPTGDSRSLAAAMTHALADPDC 318
Cdd:cd03801  260 elPALYAAAD---VFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPPDDVEALADALLRLLADPEL 336

                        330       340       350
                 ....*....|....*....|....*....|...
gi 739622893 319 ALQYGLNARDRIATHtHSAmhERRAEEIDREFR 351
Cdd:cd03801  337 RARLGRAARERVAER-FSW--ERVAERLLDLYR 366
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 45-338 1.86e-19

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 88.14  E-value: 1.86e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893  45 VVLRIPRIAALLWRviGQHEIVHTGLAGwPFPLGWIAAPIARIRRrflVIVVESSFWRVVPGTAGVAARLKARVFEAANR 124
Cdd:cd03807   64 DPGVLLRLAKLIRK--RNPDVVHTWMYH-ADLIGGLAAKLAGGVK---VIWSVRSSNIPQRLTRLVRKLCLLLSKFSPAT 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 125 LCVTWAAATFFTTDAYAA----------ELGKGARGYKSvspATWIDDATILSRETILarqkrpdarLLFVGRLSSAKGI 194
Cdd:cd03807  138 VANSSAVAEFHQEQGYAKnkivviyngiDLFKLSPDDAS---RARARRRLGLAEDRRV---------IGIVGRLHPVKDH 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 195 DVLLSAIAQ-----SDVVVDILGEGDRRADCLAIAEQF--PERVRLLESIPYGPGFFETLDrytALVVPTLSDEQPRIIA 267
Cdd:cd03807  206 SDLLRAAALlvethPDLRLLLVGRGPERPNLERLLLELglEDRVHLLGERSDVPALLPAMD---IFVLSSRTEGFPNALL 282

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 739622893 268 DAFARGVPVIASATtGNCGFVTRDHSGWLVPTGDSRSLAAAMTHALADPDCALQYGLNARDRIA-THTHSAM 338
Cdd:cd03807  283 EAMACGLPVVATDV-GGAAELVDDGTGFLVPAGDPQALADAIRALLEDPEKRARLGRAARERIAnEFSIDAM 353
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 182-329 1.23e-18

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 81.94  E-value: 1.23e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893  182 LLFVGRLSSAKGIDVLLSAIAQ-----SDVVVDILGEGDR--RADCLAIAEQFPERVRLLESIPYG--PGFFETLDrytA 252
Cdd:pfam00534   5 ILFVGRLEPEKGLDLLIKAFALlkeknPNLKLVIAGDGEEekRLKKLAEKLGLGDNVIFLGFVSDEdlPELLKIAD---V 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 739622893  253 LVVPTLSDEQPRIIADAFARGVPVIASATTGNCGFVTRDHSGWLVPTGDSRSLAAAMTHALADPDCALQYGLNARDR 329
Cdd:pfam00534  82 FVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPNNAEALAEAIDKLLEDEELRERLGENARKR 158
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
181-315 4.54e-18

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 79.48  E-value: 4.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893  181 RLLFVGRLSS-AKGIDVLLSAIAQ-----SDVVVDILGEGDRRAdCLAIAEQFPERVRLLesipygpGFFETLDRY---- 250
Cdd:pfam13692   3 VILFVGRLHPnVKGVDYLLEAVPLlrkrdNDVRLVIVGDGPEEE-LEELAAGLEDRVIFT-------GFVEDLAELlaaa 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 739622893  251 TALVVPTLSDEQPRIIADAFARGVPVIASATTGNCGFVTRDHsGWLVPTGDSRSLAAAMTHALAD 315
Cdd:pfam13692  75 DVFVLPSLYEGFGLKLLEAMAAGLPVVATDVGGIPELVDGEN-GLLVPPGDPEALAEAILRLLED 138
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 160-322 2.53e-17

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 82.02  E-value: 2.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 160 IDDATILSRETILaRQKRPDARLLFVGRLSSAKGIDVLLSAIAQ-----SDVVVDILGEGDRRADCLAIAEQF--PERVR 232
Cdd:cd03811  170 IDRIRALAKEPIL-NEPEDGPVILAVGRLDPQKGHDLLIEAFAKlrkkyPDVKLVILGDGPLREELEKLAKELglAERVI 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 233 LLesipygpGF----FETLDRYTALVVPTLSDEQPRIIADAFARGVPVIASATTGNCGFVTRDHSGWLVPTGDSRSLAAA 308
Cdd:cd03811  249 FL-------GFqsnpYPYLKKADLFVLSSRYEGFPNVLLEAMALGTPVVSTDCPGPREILDDGENGLLVPDGDAAALAGI 321

                        170
                 ....*....|....
gi 739622893 309 MTHALADPDCALQY 322
Cdd:cd03811  322 LAALLQKKLDAALR 335
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 11-333 2.84e-16

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 79.31  E-value: 2.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893  11 TLVCPARDLRPPADWLAC--CDDRLTILNVGPLSRGVVLRIPRI--------AALLWRVIGQHE----IVHTGlagwPFP 76
Cdd:cd03794   35 TVLTPSPNYPLGRIFAGAteTKDGIRVIRVKLGPIKKNGLIRRLlnylsfalAALLKLLVREERpdviIAYSP----PIT 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893  77 LGWIAAPIARIRRRFLVIVVESSF--WRVVPGtaGVAARLKARVFEAANRLCVTWAAATFFTTDAYAAEL-GKGARGYKS 153
Cdd:cd03794  111 LGLAALLLKKLRGAPFILDVRDLWpeSLIALG--VLKKGSLLKLLKKLERKLYRLADAIIVLSPGLKEYLlRKGVPKEKI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 154 VSPATWIDDATILSRETILARQKRPDA---RLLFVGRLSSAKGIDVLLSAIA----QSDVVVDILGEGDRRADCLAIAEQ 226
Cdd:cd03794  189 IVIPNWADLEEFKPPPKDELRKKLGLDdkfVVVYAGNIGKAQGLETLLEAAErlkrRPDIRFLFVGDGDEKERLKELAKA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 227 F-PERVRLLESIPYG--PGFFETLDrytALVVPtLSDEQPRIIA------DAFARGVPVIASATTGNCGFVTRDHSGWLV 297
Cdd:cd03794  269 RgLDNVTFLGRVPKEevPELLSAAD---VGLVP-LKDNPANRGSspsklfEYMAAGKPILASDDGGSDLAVEINGCGLVV 344

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 739622893 298 PTGDSRSLAAAMTHALADPDCALQYGLNARDRIATH 333
Cdd:cd03794  345 EPGDPEALADAILELLDDPELRRAMGENGRELAEEK 380
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 181-330 3.27e-16

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 78.79  E-value: 3.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 181 RLLFVGRLSSAKGIDVLLSAIAQ-----SDVVVDILGEGDRRADCLAIAEQF--PERVRLLesipygpGFFETLDRYTA- 252
Cdd:cd03808  191 VFLFVARLLKDKGIDELIEAAKIlkkkgPNVRFLLVGDGELENPSEILIEKLglEGRIEFL-------GFRSDVPELLAe 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 253 ---LVVPTLSDEQPRIIADAFARGVPVIASATTGNCGFVTRDHSGWLVPTGDSRSLAAAMTHALADPDCALQYGLNARDR 329
Cdd:cd03808  264 sdvFVLPSYREGLPRSLLEAMAAGRPVITTDVPGCRELVIDGVNGFLVPPGDVEALADAIEKLIEDPELRKEMGEAARKR 343


                 .
gi 739622893 330 I 330
Cdd:cd03808  344 V 344
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 174-317 1.49e-15

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 76.98  E-value: 1.49e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 174 RQKRPDARLLFVGRLSSAKGIDVLLSA---IAQSDVVVDILGEGDrradcLAIAEQFP--ERVRLLESIPYG--PGFFET 246
Cdd:cd03823  186 RPGTERLRFGYIGRLTEEKGIDLLVEAfkrLPREDIELVIAGHGP-----LSDERQIEggRRIAFLGRVPTDdiKDFYEK 260

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 739622893 247 LDrytALVVPTLSDEQ-PRIIADAFARGVPVIASATTGNCGFVTRDHSGWLVPTGDSRSLAAAMTHALADPD 317
Cdd:cd03823  261 ID---VLVVPSIWPEPfGLVVREAIAAGLPVIASDLGGIAELIQPGVNGLLFAPGDAEDLAAAMRRLLTDPA 329
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 252-346 9.34e-14

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 67.32  E-value: 9.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 252 ALVVPTLSDEQPRIIADAFARGVPVIASATTGNCGFVTRDHSGWLVPTGDSRSLAAAMTHALADPDCALQYGLNARDRIA 331
Cdd:COG0438   23 VFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGDPEALAEAILRLLEDPELRRRLGEAARERAE 102

                         90
                 ....*....|....*
gi 739622893 332 THTHSAMHERRAEEI 346
Cdd:COG0438  103 ERFSWEAIAERLLAL 117
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 47-334 1.47e-13

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 70.85  E-value: 1.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893  47 LRIPRIAALLWRVIGQHEI----VHTGLAGWpfpLGWIAAPIARIRrrfLVIVVESSFWrVVPGTAGVAARLKARVFEAA 122
Cdd:cd03819   59 LRALLGNVRLARLIRRERIdlihAHSRAPAW---LGWLASRLTGVP---LVTTVHGSYL-ATYHPKDFALAVRARGDRVI 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 123 nrlCVTWAAATFfTTDAYAAELGKGARGYKSVSPATWIDDATILSRETILARQKRPdaRLLFVGRLSSAKGIDVLLSAIA 202
Cdd:cd03819  132 ---AVSELVRDH-LIEALGVDPERIRVIPNGVDTDRFPPEAEAEERAQLGLPEGKP--VVGYVGRLSPEKGWLLLVDAAA 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 203 ----QSDVVVDILGEGDRRADCLAIAEQ--FPERVRLLESIPYGPGFFETLDrytALVVPTLSDEQPRIIADAFARGVPV 276
Cdd:cd03819  206 elkdEPDFRLLVAGDGPERDEIRRLVERlgLRDRVTFTGFREDVPAALAASD---VVVLPSLHEEFGRVALEAMACGTPV 282

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 739622893 277 IASATTGNCGFVTRDHSGWLVPTGDSRSLAAAMTHALADPDCALQYGLNARDRIATHT 334
Cdd:cd03819  283 VATDVGGAREIVVHGRTGLLVPPGDAEALADAIRAAKLLPEAREKLQAAAALTEAVRE 340
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 183-333 1.82e-13

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 70.77  E-value: 1.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 183 LFVGRLSSAKGIDVLLSAIAQSDVVVDILGEGDRRADCLA-IAEQFPERVRLLesipygpGFFETLDRYT------ALVV 255
Cdd:cd03795  195 LFIGRLVYYKGLDYLIEAAQYLNYPIVIGGEGPLKPDLEAqIELNLLDNVKFL-------GRVDDEEKVIylhlcdVFVF 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 256 PT-LSDEQPRII-ADAFARGVPVIASATTGNCGFVTRD-HSGWLVPTGDSRSLAAAMTHALADPDCALQYGLNARDRIAT 332
Cdd:cd03795  268 PSvLRSEAFGIVlLEAMMCGKPVISTNIGTGVPYVNNNgETGLVVPPKDPDALAEAIDKLLSDEELRESYGENAKKRFEE 347


                 .
gi 739622893 333 H 333
Cdd:cd03795  348 L 348
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 176-317 3.67e-13

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 69.72  E-value: 3.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 176 KRPDARL-LFVGRLSSAKGIDVLLSAIA-----QSDVVVDILGEGDRRADCLAIAEQ--FPERVRLLESIPYG--PGFFE 245
Cdd:cd03798  196 LPLDAFViLFVGRLIPRKGIDLLLEAFArlakaRPDVVLLIVGDGPLREALRALAEDlgLGDRVTFTGRLPHEqvPAYYR 275

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 739622893 246 TLDrytALVVPTLSDEQPRIIADAFARGVPVIASATTGNCGFVTRDHSGWLVPTGDSRSLAAAMTHALADPD 317
Cdd:cd03798  276 ACD---VFVLPSRHEGFGLVLLEAMACGLPVVATDVGGIPEVVGDPETGLLVPPGDADALAAALRRALAEPY 344
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 181-333 3.69e-13

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 69.79  E-value: 3.69e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 181 RLLFVGRLSSAKGIDVLLSAIAQ-----SDVVVDILGEGDRRADCL-AIAE-QFPERVRLLESIPYgPGFFETLDRYTAL 253
Cdd:cd03799  176 RILTVGRLTEKKGLEYAIEAVAKlaqkyPNIEYQIIGDGDLKEQLQqLIQElNIGDCVKLLGWKPQ-EEIIEILDEADIF 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 254 VVPTLSDEQ------PRIIADAFARGVPVIASATTGNCGFVTRDHSGWLVPTGDSRSLAAAMTHALADPDCALQYGLNAR 327
Cdd:cd03799  255 IAPSVTAADgdqdgpPNTLKEAMAMGLPVISTEHGGIPELVEDGVSGFLVPERDAEAIAEKLTYLIEHPAIWPEMGKAGR 334


                 ....*.
gi 739622893 328 DRIATH 333
Cdd:cd03799  335 ARVEEE 340
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 174-336 4.51e-13

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 69.62  E-value: 4.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 174 RQKRPDA-RLLFVGRLSSAKGIDVLLSAIAQS----DVVVDILGEGDRRADC--LAIAEQFPERVRLLESIPYGpgffET 246
Cdd:cd03817  195 LGLPPDEpILLYVGRLAKEKNIDFLLRAFAELkkepNIKLVIVGDGPEREELkeLARELGLADKVIFTGFVPRE----EL 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 247 LDRYTA---LVVPTLSDEQPRIIADAFARGVPVIASATTGNCGFVTRDHSGWLVPTGDSRsLAAAMTHALADPDCALQYG 323
Cdd:cd03817  271 PEYYKAadlFVFASTTETQGLVYLEAMAAGLPVVAAKDPAASELVEDGENGFLFEPNDET-LAEKLLHLRENLELLRKLS 349

                        170
                 ....*....|...
gi 739622893 324 LNArdRIATHTHS 336
Cdd:cd03817  350 KNA--EISAREFA 360
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 177-297 9.93e-12

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 63.96  E-value: 9.93e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 177 RPDARLLFVGRLSSAKGIDVLLSAIAQ-----SDVVVDILGEGDRRAD--CLAIAEQFPERVRLLESIPYGPGFFETLDR 249
Cdd:cd01635  108 LPLADKVSVGRLVPEKGIDLLLEALALlkarlPDLVLVLVGGGGEREEeeALAAALGLLERVVIIGGLVDDEVLELLLAA 187

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 739622893 250 YTALVVPTLSDEQPRIIADAFARGVPVIASATTGNCGFVTRDHSGWLV 297
Cdd:cd01635  188 ADVFVLPSRSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGLLV 235
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 159-330 1.86e-11

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 64.57  E-value: 1.86e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 159 WIDDATILSRETILARQKRPDA-----------------------RLLFVGRLSSAKGIDVLLSAIAQ-----SDVVVDI 210
Cdd:cd03820  138 RADKIVVLTEADKLKKYKQPNSnvvvipnplsfpseepstnlkskRILAVGRLTYQKGFDLLIEAWALiakkhPDWKLRI 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 211 LGEGDRRADCLAIAEQFpervRLLESIPYGPGF---FETLDRYTALVVPTLSDEQPRIIADAFARGVPVIASAttGNCG- 286
Cdd:cd03820  218 YGDGPEREELEKLIDKL----GLEDRVKLLGPTkniAEEYANSSIFVLSSRYEGFPMVLLEAMAYGLPIISFD--CPTGp 291

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 739622893 287 --FVTRDHSGWLVPTGDSRSLAAAMTHALADPDCALQYGLNARDRI 330
Cdd:cd03820  292 seIIEDGENGLLVPNGDVDALAEALLRLMEDEELRKKMGKNARKNA 337
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 252-333 2.64e-11

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 64.28  E-value: 2.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 252 ALVVPTLSDEQPRIIADAFARGVPVIASATTGNCGFVTRDHSGWLVPTGDSRSLAAAMTHALADPDCALQYGLNARDRIA 331
Cdd:cd03825  266 LFVHPSLADNLPNTLLEAMACGTPVVAFDTGGSPEIVQHGVTGYLVPPGDVQALAEAIEWLLANPKERESLGERARALAE 345


                 ..
gi 739622893 332 TH 333
Cdd:cd03825  346 NH 347
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 174-327 1.55e-10

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 61.70  E-value: 1.55e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 174 RQKRPDAR-LLFVGRLSSAKGIDVLLSAIAQ-----SDVVVDILGEGDRRADCLAIAEQFpERVRLLESIPYgPGFFETL 247
Cdd:cd05844  183 RDPAERAPtILFVGRLVEKKGCDVLIEAFRRlaarhPTARLVIAGDGPLRPALQALAAAL-GRVRFLGALPH-AEVQDWM 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 248 DRYTALVVPTL------SDEQPRIIADAFARGVPVIASATTGNCGFVTRDHSGWLVPTGDSRSLAAAMTHALADPDCALQ 321
Cdd:cd05844  261 RRAEIFCLPSVtaasgdSEGLGIVLLEAAACGVPVVSSRHGGIPEAILDGETGFLVPEGDVDALADALQALLADRALADR 340


                 ....*.
gi 739622893 322 YGLNAR 327
Cdd:cd05844  341 MGGAAR 346
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 178-334 4.32e-08

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 54.22  E-value: 4.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 178 PDARLLFVGRLSSAKGIDVLLSAI----AQSDVVVDILGEGDRRAdclAIAEQFPERVRLlesipygpGFF--ETLDRYT 251
Cdd:cd03814  197 GRPLLLYVGRLAPEKNLEALLDADlplaASPPVRLVVVGDGPARA---ELEARGPDVIFT--------GFLtgEELARAY 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 252 A----LVVPTLSDEQPRIIADAFARGVPVIASATTGNCGFVTRDHSGWLVPTGDSRSLAAAMTHALADPDCALQYGLNAR 327
Cdd:cd03814  266 AsadvFVFPSRTETFGLVVLEAMASGLPVVAADAGGPRDIVRPGGTGALVEPGDAAAFAAALRALLEDPELRRRMAARAR 345


                 ....*..
gi 739622893 328 DRIATHT 334
Cdd:cd03814  346 AEAERYS 352
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 50-327 5.41e-08

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 53.91  E-value: 5.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893  50 PRIAALLWRVIGQHEIVH-TGLagWPFPLGwIAAPIARIRRRFLVIVVESSfwrVVPGTAGVAARLKARVFEAANRLCVT 128
Cdd:cd03821   78 PGLPNWLRRNLREYDVVHiHGV--WTYTSL-AACKLARRRGIPYVVSPHGM---LDPWALQQKHWKKRIALHLIERRNLN 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 129 WAAATFFT-TDAYAAELGKGARGyksvsPATWIDDATILSRETILARQKR-----PDAR-LLFVGRLSSAKGIDVLLSAI 201
Cdd:cd03821  152 NAALVHFTsEQEADELRRFGLEP-----PIAVIPNGVDIPEFDPGLRDRRkhnglEDRRiILFLGRIHPKKGLDLLIRAA 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 202 AQ-----SDVVVDILGEGD---RRADCLAIAEQFPERVRLLESIpYGPGFFETLDRYTALVVPTLSDEQPRIIADAFARG 273
Cdd:cd03821  227 RKlaeqgRDWHLVIAGPDDgayPAFLQLQSSLGLGDRVTFTGPL-YGEAKWALYASADLFVLPSYSENFGNVVAEALACG 305

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 739622893 274 VPVIasaTTGNCGF--VTRDHSGWLVPTGDSrSLAAAMTHALADPDCALQYGLNAR 327
Cdd:cd03821  306 LPVV---ITDKCGLseLVEAGCGVVVDPNVS-SLAEALAEALRDPADRKRLGEMAR 357
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 160-333 1.10e-07

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 53.01  E-value: 1.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 160 IDDATILSRETILARQKRPdarLLFVGRLSSAKGIDVLLSAIAQS-----DVVVDILG--EGDRRADCLAIAEQFPERVR 232
Cdd:cd03800  204 VDRAEARRARLLLPPDKPV---VLALGRLDPRKGIDTLVRAFAQLpelreLANLVLVGgpSDDPLSMDREELAELAEELG 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 233 LLESIPYgPGFF---ETLDRYTA---LVVPTLSDEQPRIIADAFARGVPVIASATTGNCGFVTRDHSGWLVPTGDSRSLA 306
Cdd:cd03800  281 LIDRVRF-PGRVsrdDLPELYRAadvFVVPSLYEPFGLTAIEAMACGTPVVATAVGGLQDIVRDGRTGLLVDPHDPEALA 359

                        170       180
                 ....*....|....*....|....*..
gi 739622893 307 AAMTHALADPDCALQYGLNARDRIATH 333
Cdd:cd03800  360 AALRRLLDDPALWQRLSRAGLERARAH 386
GT5_Glycogen_synthase_DULL1-like cd03791
Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 ...
 177-326 2.32e-06

Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 family of glycosyltransferases. Glycogen synthase (EC:2.4.1.21) catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family includes starch synthases of plants, such as DULL1 in Zea mays and glycogen synthases of various organisms.


Pssm-ID: 340822 [Multi-domain]  Cd Length: 474  Bit Score: 49.10  E-value: 2.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 177 RPDARLL-FVGRLSSAKGIDVLLSAI---AQSDVVVDILGEGDRR--ADCLAIAEQFPERVRLLesipygPGFFETLDR- 249
Cdd:cd03791  291 DPDAPLFgFVGRLTEQKGVDLILDALpelLEEGGQLVVLGSGDPEyeQAFRELAERYPGKVAVV------IGFDEALAHr 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 250 -YTA---LVVPTLsDE-----QprIIadAFARGVPVIASATTG------NCGFVTRDHSGWLVPTGDSRSLAAAMTHALA 314
Cdd:cd03791  365 iYAGadfFLMPSR-FEpcglvQ--MY--AMRYGTLPIVRRTGGladtvfDYDPETGEGTGFVFEDYDAEALLAALRRALA 439

                        170
                 ....*....|....*
gi 739622893 315 ---DPDCALQYGLNA 326
Cdd:cd03791  440 lyrNPELWRKLQKNA 454
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 173-330 1.23e-05

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 46.94  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 173 ARQKRPDA---RLLFVGRLSSAKGIDVLLSAI-----AQSDVVVDILG--EGDRR--ADCLAIAEQ--------FPERVR 232
Cdd:cd03813  284 AREERPEKeppVVGLVGRVVPIKDVKTFIRAFklvrrAMPDAEGWLIGpeDEDPEyaQECKRLVASlglenkvkFLGFQN 363

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 233 LLESIPYGpgffetldrytALVVPT-LSDEQPRIIADAFARGVPVIAS-------------ATTGNCGFVtrdhsgwlVP 298
Cdd:cd03813  364 IKEYYPKL-----------GLLVLTsISEGQPLVILEAMASGVPVVATdvgscreliygadDALGQAGLV--------VP 424

                        170       180       190
                 ....*....|....*....|....*....|..
gi 739622893 299 TGDSRSLAAAMTHALADPDCALQYGLNARDRI 330
Cdd:cd03813  425 PADPEALAEALIKLLRDPELRQAFGEAGRKRV 456
GlgA COG0297
Glycogen synthase [Carbohydrate transport and metabolism];
177-233 2.36e-05

Glycogen synthase [Carbohydrate transport and metabolism];


Pssm-ID: 440066 [Multi-domain]  Cd Length: 476  Bit Score: 45.85  E-value: 2.36e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 739622893 177 RPDARLL-FVGRLSSAKGIDVLLSA---IAQSDVVVDILGEGDRR--ADCLAIAEQFPERVRL 233
Cdd:COG0297  292 DPDAPLIgMVSRLTEQKGLDLLLEAldeLLEEDVQLVVLGSGDPEyeEAFRELAARYPGRVAV 354
GT4_ExpC-like cd03818
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 ...
 269-333 2.88e-05

Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II).


Pssm-ID: 340845 [Multi-domain]  Cd Length: 396  Bit Score: 45.43  E-value: 2.88e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 739622893 269 AFARGVPVIASATTGNCGFVTRDHSGWLVPTGDSRSLAAAMTHALADPDCALQYGLNARDRIATH 333
Cdd:cd03818  320 AMACGCPVIGSDTAPVREVIRDGRNGLLVDFFDPDALAAAVLELLEDPDRAAALRRAARRTVERS 384
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
182-333 4.43e-05

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 45.17  E-value: 4.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 182 LLFVGRLSSAKGIDVLLSAI-----AQSDVVVDILGE------GDRRA---DCLAIAEQFPERVRLLESIPygPgffETL 247
Cdd:PRK15484 196 LLYAGRISPDKGILLLMQAFeklatAHSNLKLVVVGDptasskGEKAAyqkKVLEAAKRIGDRCIMLGGQP--P---EKM 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 248 DRYTAL----VVPTLSDEQPRIIA-DAFARGVPVIASATTGNCGFVTRDHSGW-LVPTGDSRSLAAAMTHALADPDCAlQ 321
Cdd:PRK15484 271 HNYYPLadlvVVPSQVEEAFCMVAvEAMAAGKPVLASTKGGITEFVLEGITGYhLAEPMTSDSIISDINRTLADPELT-Q 349

                        170
                 ....*....|..
gi 739622893 322 YGLNARDRIATH 333
Cdd:PRK15484 350 IAEQAKDFVFSK 361
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 268-350 1.00e-04

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 43.88  E-value: 1.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 268 DAFARGVPVIASATTGNCGFVTRDHSGWLVPTGDSRSLAAAMTHALADPDCALQYGLNARDRIATHTHSAMHERRAEEID 347
Cdd:cd04962  288 EAMACGVPVVSSNAGGIPEVVKHGETGFLSDVGDVDAMAKSALSILEDDELYNRMGRAARKRAAERFDPERIVPQYEAYY 367


                 ...
gi 739622893 348 REF 350
Cdd:cd04962  368 RRL 370
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 179-309 2.36e-04

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 42.82  E-value: 2.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 179 DARLLFVGRLSSAKGIDVLLSAIAQ-----SDVVVDILGEGDRRADCLAIAEQFP--ERVRLLESIPYGPGFFETLDRYt 251
Cdd:cd04951  188 EFVILNVGRLTEAKDYPNLLLAISElilskNDFKLLIAGDGPLRNELERLICNLNlvDRVILLGQISNISEYYNAADLF- 266

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 739622893 252 alVVPTLSDEQPRIIADAFARGVPVIASaTTGNCGFVTRDHSgWLVPTGDSRSLAAAM 309
Cdd:cd04951  267 --VLSSEWEGFGLVVAEAMACERPVVAT-DAGGVAEVVGDHN-YVVPVSDPQLLAEKI 320
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 153-317 1.28e-03

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 40.42  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 153 SVSPATWIDDATILSRETILARQKRPDAR-LLFVGRLSSAKGIDVLLSAIAQSD--------VVVDILGEGDRRADCLAI 223
Cdd:cd03809  165 VVIPLGVDPSFFPPESAAVLIAKYLLPEPyFLYVGTLEPRKNHERLLKAFALLKkqggdlklVIVGGKGWEDEELLDLVK 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739622893 224 AEQFPERVRLLESIPYgpgffETLDRY----TALVVPTLsDE---QPriIADAFARGVPVIASATT------GNCgfvtr 290
Cdd:cd03809  245 KLGLGGRVRFLGYVSD-----EDLPALyrgaRAFVFPSL-YEgfgLP--VLEAMACGTPVIASNISvlpevaGDA----- 311

                        170       180
                 ....*....|....*....|....*..
gi 739622893 291 dhsGWLVPTGDSRSLAAAMTHALADPD 317
Cdd:cd03809  312 ---ALYFDPLDPESIADAILRLLEDPS 335
Glyco_trans_1_2 pfam13524
Glycosyl transferases group 1;
268-346 3.16e-03

Glycosyl transferases group 1;


Pssm-ID: 433281 [Multi-domain]  Cd Length: 93  Bit Score: 36.43  E-value: 3.16e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 739622893  268 DAFARGVPVIASATTGNCGFVTRDHSGWLVPtgDSRSLAAAMTHALADPDCALQYGLNARDRIATHtHSAMHerRAEEI 346
Cdd:pfam13524  18 EAAACGAPLLTDRTPGLEELFEPGEEILLYR--DPEELAEKIRYLLEHPEERRAIAAAGRERVLAE-HTYAH--RAEQL 91
glgA PRK00654
glycogen synthase GlgA;
184-233 4.04e-03

glycogen synthase GlgA;


Pssm-ID: 234809 [Multi-domain]  Cd Length: 466  Bit Score: 38.95  E-value: 4.04e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 739622893 184 FVGRLSSAKGIDVLLSAIA---QSDVVVDILGEGDRR--ADCLAIAEQFPERVRL 233
Cdd:PRK00654 287 MVSRLTEQKGLDLVLEALPellEQGGQLVLLGTGDPEleEAFRALAARYPGKVGV 341
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 266-333 6.05e-03

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 38.46  E-value: 6.05e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 739622893 266 IADAFARGVPVIASATTGNCGFVTRDHSGWLVPTGDSRSLaaAMTHALADPDCALQYGLNARDRIATH 333
Cdd:cd03792  296 VSEALWKGKPVIATPAGGIPLQVIDGETGFLVNSVEGAAV--RILRLLTDPELRRKMGLAAREHVRDN 361
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
 269-330 8.63e-03

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 37.95  E-value: 8.63e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 739622893 269 AFARGVPVIASATTGNCGFVTRDHSGWLVPtGDSRSLAAAMTHALADPDCALQYGLNARDRI 330
Cdd:cd03805  319 AMYAGKPVIACNSGGPLETVVEGVTGFLCE-PTPEAFAEAMLKLANDPDLADRMGAAGRKRV 379
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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