|
Name |
Accession |
Description |
Interval |
E-value |
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
14-360 |
4.89e-94 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 284.82 E-value: 4.89e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 14 PDFAELFAALPVAVLVVDDAGCIVFANAECETLLNLSERAMLGHPLVSVMTPPSQPNA------RDNHGLAAFDTEIALK 87
Cdd:COG3852 7 ELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSPLRElleralAEGQPVTEREVTLRRK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 88 RGGKIRVDYIETRVADHPGWH--TITLHHAATSRRMGHSADRAAAARAAIGAAAMLAHEIKNPLSGIRGAAQLLS---KG 162
Cdd:COG3852 87 DGEERPVDVSVSPLRDAEGEGgvLLVLRDITERKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQLLErelPD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 163 KGAEELTTLITTEVDRIAALIDRMQDFTDTRPLKLAPENIYPLLGHARRVALAGFAQHVTIEERFDPSLPSVQIDRDATL 242
Cdd:COG3852 167 DELREYTQLIIEEADRLNNLVDRLLSFSRPRPPEREPVNLHEVLERVLELLRAEAPKNIRIVRDYDPSLPEVLGDPDQLI 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 243 QVVLNLLKNASEATQEQadARITLATAYRHGMAVapapGKPRRPLPIEICVIDNGPGPPADIAEHLFDPFISGKPEGQGL 322
Cdd:COG3852 247 QVLLNLVRNAAEAMPEG--GTITIRTRVERQVTL----GGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEKGTGL 320
|
330 340 350
....*....|....*....|....*....|....*....
gi 739637604 323 GLALVDKLVRDMGGIIQFarEGAPPM-TVFRILLPRGDS 360
Cdd:COG3852 321 GLAIVQKIVEQHGGTIEV--ESEPGKgTTFRIYLPLEQA 357
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
19-360 |
1.05e-53 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 182.47 E-value: 1.05e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 19 LFAALPVAVLVVDDAGCIVFANAECETLLNLSERAMLGHPLVSVMTPPSQPNARDNHGLAAFDTEIALKRGGKIRVDYIE 98
Cdd:COG5000 95 ILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAELLREALERGWQEEIELTRDGRRTLLVRA 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 99 TRVADHpGW----HTIT-LHHA---AT----SRRMGHsadraaaaraaigaaamlahEIKNPLSGIRGAAQLLSKGKGA- 165
Cdd:COG5000 175 SPLRDD-GYvivfDDITeLLRAerlAAwgelARRIAH--------------------EIKNPLTPIQLSAERLRRKLADk 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 166 --------EELTTLITTEVDRIAALIDRMQDFTDTRPLKLAPENIYPLLGHARR-VALAGFAQHVTIEERFDPSLPSVQI 236
Cdd:COG5000 234 leedredlERALDTIIRQVDRLKRIVDEFLDFARLPEPQLEPVDLNELLREVLAlYEPALKEKDIRLELDLDPDLPEVLA 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 237 DRDATLQVVLNLLKNASEATQEQAdaRITLATAYRHGMavapapgkprrplpIEICVIDNGPGPPADIAEHLFDPFISGK 316
Cdd:COG5000 314 DRDQLEQVLINLLKNAIEAIEEGG--EIEVSTRREDGR--------------VRIEVSDNGPGIPEEVLERIFEPFFTTK 377
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 739637604 317 PEGQGLGLALVDKLVRDMGGIIQFA-REGAPpmTVFRILLPRGDS 360
Cdd:COG5000 378 PKGTGLGLAIVKKIVEEHGGTIELEsRPGGG--TTFTIRLPLAEE 420
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
143-357 |
6.90e-44 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 154.96 E-value: 6.90e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLSK-------GKGAEELTTLITTEVDRIAALIDRMQDFTDTRPLKLAPENIYPLLGHARRVALA 215
Cdd:COG4191 151 HEINNPLAAILGNAELLRRrledepdPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRP 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 216 GFAQH-VTIEERFDPSLPSVQIDRDATLQVVLNLLKNASEATQEQADARITLATAYRHGMavapapgkprrplpIEICVI 294
Cdd:COG4191 231 RLKARgIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGEGGRITISTRREGDY--------------VVISVR 296
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 739637604 295 DNGPGPPADIAEHLFDPFISGKPEGQ--GLGLALVDKLVRDMGGIIQFAREgAPPMTVFRILLPR 357
Cdd:COG4191 297 DNGPGIPPEVLERIFEPFFTTKPVGKgtGLGLSISYGIVEKHGGRIEVESE-PGGGTTFTITLPL 360
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
14-356 |
6.59e-42 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 149.46 E-value: 6.59e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 14 PDFAELFAALPVAVLVVDDAGCIVFANAECETLLNLSERAMLGHPLVSVMTPPSQPNARDNHGLAA----FDTEIALKRG 89
Cdd:PRK11073 7 PDAGQILNSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLNIELMRESLQAgqgfTDNEVTLVID 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 90 GKIRV-DYIETRVADhpGWHTITLHHAATSRRMGHSADRAAAARAAIGAAAMLAHEIKNPLSGIRGAAQLLSKG---KGA 165
Cdd:PRK11073 87 GRSHIlSLTAQRLPE--GMILLEMAPMDNQRRLSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKAlpdPAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 166 EELTTLITTEVDRIAALIDRMqdFTDTRPLKLAPENIYPLLGHARRVALAGFAQHVTIEERFDPSLPSVQIDRDATLQVV 245
Cdd:PRK11073 165 TEYTKVIIEQADRLRNLVDRL--LGPQRPGTHVTESIHKVAERVVQLVSLELPDNVRLIRDYDPSLPELAHDPDQIEQVL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 246 LNLLKNASEATQEQaDARITLAT-----AYRHGMavapapgkpRRPLPIEICVIDNGPGPPADIAEHLFDPFISGKPEGQ 320
Cdd:PRK11073 243 LNIVRNALQALGPE-GGTITLRTrtafqLTLHGE---------RYRLAARIDIEDNGPGIPPHLQDTLFYPMVSGREGGT 312
|
330 340 350
....*....|....*....|....*....|....*.
gi 739637604 321 GLGLALVDKLVRDMGGIIQFarEGAPPMTVFRILLP 356
Cdd:PRK11073 313 GLGLSIARNLIDQHSGKIEF--TSWPGHTEFSVYLP 346
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
143-358 |
3.60e-38 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 139.27 E-value: 3.60e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLSKGKGAE--ELTTLITTEVDRIAALIDRMQDFT--DTRPLKLAPE--NIYPLLGHA-RRVALA 215
Cdd:COG0642 119 HELRTPLTAIRGYLELLLEELDEEqrEYLETILRSADRLLRLINDLLDLSrlEAGKLELEPEpvDLAELLEEVvELFRPL 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 216 GFAQHVTIEERFDPSLPSVQIDRDATLQVVLNLLKNASEATQEqaDARITLATAYRHGMAVapapgkprrplpieICVID 295
Cdd:COG0642 199 AEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPE--GGTVTVSVRREGDRVR--------------ISVED 262
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 296 NGPGPPADIAEHLFDPFISGKP----EGQGLGLALVDKLVRDMGGIIQFARE---GappmTVFRILLPRG 358
Cdd:COG0642 263 TGPGIPPEDLERIFEPFFRTDPsrrgGGTGLGLAIVKRIVELHGGTIEVESEpgkG----TTFTVTLPLA 328
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
143-360 |
3.10e-37 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 134.26 E-value: 3.10e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLSKGKG-----AEELTTLITTEVDRIAALIDRMQDFT----DTRPLKLAPENIYPLLGHA-RRV 212
Cdd:COG2205 25 HELRTPLTSILGAAELLLDEEDlspeeRRELLEIIRESAERLLRLIEDLLDLSrlesGKLSLELEPVDLAELLEEAvEEL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 213 ALAGFAQHVTIEERFDPSLPSVQIDRDATLQVVLNLLKNASEATQEqaDARITLATAYRHGMavapapgkprrplpIEIC 292
Cdd:COG2205 105 RPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPP--GGTITISARREGDG--------------VRIS 168
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 739637604 293 VIDNGPGPPADIAEHLFDPF----ISGKPEGQGLGLALVDKLVRDMGGIIQFAREGaPPMTVFRILLPRGDS 360
Cdd:COG2205 169 VSDNGPGIPEEELERIFERFyrgdNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEP-GGGTTFTVTLPLAES 239
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
243-356 |
3.84e-33 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 119.04 E-value: 3.84e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 243 QVVLNLLKNASEATQEQaDARITLATAYRHGMAVapapGKPRRPLPIEICVIDNGPGPPADIAEHLFDPFISGKPEGQGL 322
Cdd:cd16918 3 QVFLNLVRNAAQALAGS-GGEIILRTRTQRQVTL----GHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGL 77
|
90 100 110
....*....|....*....|....*....|....
gi 739637604 323 GLALVDKLVRDMGGIIQFarEGAPPMTVFRILLP 356
Cdd:cd16918 78 GLAIAQNIVSQHGGVIEC--DSQPGHTVFSVSLP 109
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
26-357 |
3.01e-32 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 127.01 E-value: 3.01e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 26 AVLVVDDAGCIVFANAECETLLNLSERAMLGHPLVSVMtPPSQPNA---RD--NHGLAAFDTEIALK-RGGKIRVDYIET 99
Cdd:PRK11360 274 GVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELF-PPNTPFAsplLDtlEHGTEHVDLEISFPgRDRTIELSVSTS 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 100 RVADHPG---WHTITLHHAATSRRMGHSADRAAAARAAIGAAAMLAHEIKNPLSGIRGAAQLL---SKGKGAEELTTLIT 173
Cdd:PRK11360 353 LLHNTHGemiGALVIFSDLTERKRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYVQIWrqqTSDPPSQEYLSVVL 432
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 174 TEVDRIAALIDRMQDFTDTRPLKLAPENIYPLLGHARR-VALAGFAQHVTIEERFDPSLPSVQIDRDATLQVVLNLLKNA 252
Cdd:PRK11360 433 REVDRLNKVIDQLLEFSRPRESQWQPVSLNALVEEVLQlFQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINA 512
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 253 SEATQEqaDARITLATAYrhgmavaPAPGKprrplpIEICVIDNGPGPPADIAEHLFDPFISGKPEGQGLGLALVDKLVR 332
Cdd:PRK11360 513 VQAISA--RGKIRIRTWQ-------YSDGQ------VAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIIN 577
|
330 340
....*....|....*....|....*.
gi 739637604 333 DMGGIIQFA-REGAPpmTVFRILLPR 357
Cdd:PRK11360 578 AHGGDIEVEsEPGVG--TTFTLYLPI 601
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
143-357 |
6.09e-31 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 120.28 E-value: 6.09e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLSKGKGA---EELTTLITTEVDRIAALIDRMQDFTDTRPLKLAPENIYPLLGHARRVALAGFA- 218
Cdd:COG5807 156 HEIRNPLTSIKGFLQLLQESREDserEEYFNIIISEIDRINTIITELLVLSKPKKFNFKKLNLNDVLEDVIALLSTEAIl 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 219 QHVTIEERFDPSLPSVQIDRDATLQVVLNLLKNASEATQEQADARITLATAYRHgmavapapgkprrplpIEICVIDNGP 298
Cdd:COG5807 236 KNISIKYDLADDEPVINGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEGDF----------------VVISVKDEGI 299
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 739637604 299 GPPADIAEHLFDPFISGKPEGQGLGLALVDKLVRDMGGIIQF---AREGappmTVFRILLPR 357
Cdd:COG5807 300 GIPEEVLEKIGEPFFTTKEEGTGLGLSICKKIIEEHNGTIEVeskPGKG----TTFTIYLPL 357
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
143-357 |
1.23e-28 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 114.65 E-value: 1.23e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLSKGKG-----AEELTTLITTEVDRIAALIDRMQDFT----DTRPLKLAPENIYPLLGHA-RRV 212
Cdd:COG5002 174 HELRTPLTSIRGYLELLLDGAAddpeeRREYLEIILEEAERLSRLVNDLLDLSrlesGELKLEKEPVDLAELLEEVvEEL 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 213 ALAGFAQHVTIEERFDPSLPSVQIDRDATLQVVLNLLKNASEATQEqaDARITLATAYRHGMavapapgkprrplpIEIC 292
Cdd:COG5002 254 RPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPE--GGTITVSLREEDDQ--------------VRIS 317
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 739637604 293 VIDNGPGPPADIAEHLFDPF------ISGKPEGQGLGLALVDKLVRDMGGIIQFA---REGappmTVFRILLPR 357
Cdd:COG5002 318 VRDTGIGIPEEDLPRIFERFyrvdksRSRETGGTGLGLAIVKHIVEAHGGRIWVEsepGKG----TTFTITLPL 387
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
143-356 |
4.05e-26 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 108.91 E-value: 4.05e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLSKGKGAEELTTL--ITTEVDRIAALIDRMQDFTDTRPLKLAPENIYPLLGHArrVALAGfAQ- 219
Cdd:COG5809 279 HEIRNPLTSLKGFIQLLKDTIDEEQKTYLdiMLSELDRIESIISEFLVLAKPQAIKYEPKDLNTLIEEV--IPLLQ-PQa 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 220 ---HVTIEERFDPSLPSVQIDRDATLQVVLNLLKNASEATQEQADarITLATAYrhgmavaPAPGKprrplpIEICVIDN 296
Cdd:COG5809 356 llkNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGN--ITIETKA-------EDDDK------VVISVTDE 420
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 739637604 297 GPGPPADIAEHLFDPFISGKPEGQGLGLALVDKLVRDMGGIIQFARE---GappmTVFRILLP 356
Cdd:COG5809 421 GCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKITVESEvgkG----TTFSITLP 479
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
143-357 |
6.48e-26 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 107.91 E-value: 6.48e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLSKGKGAEE---LTTLITTEVDRIaalIDRMQDFTD-TRP--LKLAPENIYPLLGHARRVALAG 216
Cdd:COG5808 250 HEIRNPLTSIKGFIQLLQEKYPELEdqkYFDIIQEEIQRI---NQIVSEFLVlGKPtaKKLELDDLNELIEEILSIIDSE 326
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 217 FAQH-VTIEERFDPSLPSVQIDRDATLQVVLNLLKNASEATQEqaDARITLATAYRHGMAVapapgkprrplpieICVID 295
Cdd:COG5808 327 ANLKnIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKE--GGKLTISIENDDEKAV--------------IEVID 390
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 739637604 296 NGPGPPADIAEHLFDPFISGKPEGQGLGLALVDKLVRDMGGIIQF-AREGAppMTVFRILLPR 357
Cdd:COG5808 391 NGEGIPEDIIDEIFEPFVTTKEGGTGLGLSVCKRIVEMHGGEIDIeSEEGK--GTTFTIRLPL 451
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
143-356 |
1.08e-25 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 107.18 E-value: 1.08e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLSK----GKGAEELTTLITTEVDRIAALIDRMQDFTDTRPLKLAPENIYPLLGHARRVaLAGFA 218
Cdd:PRK10364 246 HEIRNPLSSIKGLAKYFAErapaGGEAHQLAQVMAKEADRLNRVVSELLELVKPTHLALQAVDLNDLINHSLQL-VSQDA 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 219 QHVTIEERF--DPSLPSVQIDRDATLQVVLNLLKNASEATQEQAdaRITLaTAYRHGMAVapapgkprrplpiEICVIDN 296
Cdd:PRK10364 325 NSREIQLRFtaNDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHG--VISV-TASESGAGV-------------KISVTDS 388
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 739637604 297 GPGPPADIAEHLFDPFISGKPEGQGLGLALVDKLVRDMGGIIQFA-REGAPpmTVFRILLP 356
Cdd:PRK10364 389 GKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVAsQEGKG--ATFTLWLP 447
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
19-356 |
4.53e-23 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 99.81 E-value: 4.53e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 19 LFAALPVAVLVVDDAGCIVFANAECETLLNLSERAMLGHPLVSVMTPPSQP--NARDNHGLAA-----FDTEIALKRGgk 91
Cdd:COG5805 162 LIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHPCDKEefKERIESITEVwqefiIEREIITKDG-- 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 92 iRVDYIETRVAdhPGWHT-------------ITlHHAATSRRMGHSADRAAAARAAIGAAamlaHEIKNPLSGIRGAAQL 158
Cdd:COG5805 240 -RIRYFEAVIV--PLIDTdgsvkgilvilrdIT-EKKEAEELMARSEKLSIAGQLAAGIA----HEIRNPLTSIKGFLQL 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 159 LSKGK-GAEELTTLITTEVDRIAALIDRMQDFTDTRPLKLAPENIY-------PLLGHARRValagfaQHVTIEERFDPS 230
Cdd:COG5805 312 LQPGIeDKEEYFDIMLSELDRIESIISEFLALAKPQAVNKEKENINeliqdvvTLLETEAIL------HNIQIRLELLDE 385
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 231 LPSVQIDRDATLQVVLNLLKNASEATQEqaDARITLATAYRHGMavapapgkprrplpIEICVIDNGPGPPADIAEHLFD 310
Cdd:COG5805 386 DPFIYCDENQIKQVFINLIKNAIEAMPN--GGTITIHTEEEDNS--------------VIIRVIDEGIGIPEERLKKLGE 449
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 739637604 311 PFISGKPEGQGLGLALVDKLVRDMGGIIQFAREgaPPM-TVFRILLP 356
Cdd:COG5805 450 PFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSK--VGKgTTFTITLP 494
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
19-360 |
3.34e-21 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 93.76 E-value: 3.34e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 19 LFAALPVAVLVVDDAGCIVFANAECETLLNLSEramLGHPLVSVMTPPSQPNARDnhglaafdtEIALKRGGKIRVDYIE 98
Cdd:COG3290 89 VLESIREGVIAVDRDGRITLINDAARRLLGLDA---IGRPIDEVLAEVLETGERD---------EEILLNGRVLVVNRVP 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 99 TRVADHPGWHTITLH-HAATSRRMGHsadrAAAARAAIGAAAMLAHEIKNPLSGIRGaaqLLSKGKgAEELTTLITTEVD 177
Cdd:COG3290 157 IRDDGRVVGAVATFRdRTELERLEEE----LEGVKELAEALRAQRHDFRNHLHTISG---LLQLGE-YDEALEYIDEISE 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 178 RIAALIDRMQDFTDTRPLKlapeniyPLLGHARRVALAgfaQHVTIEERFDPSLPSVQIDRDATLQVVLNLLKNASEATQ 257
Cdd:COG3290 229 ELQELIDSLLSRIGNPVLA-------ALLLGKAARARE---RGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAVE 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 258 EQAD--ARITLATAYRHGMavapapgkprrplpIEICVIDNGPGPPADIAEHLFDP-FISGKPEGQGLGLALVDKLVRDM 334
Cdd:COG3290 299 KLPEeeRRVELSIRDDGDE--------------LVIEVEDSGPGIPEELLEKIFERgFSTKLGEGRGLGLALVKQIVEKY 364
|
330 340
....*....|....*....|....*.
gi 739637604 335 GGIIQFAREGaPPMTVFRILLPRGDS 360
Cdd:COG3290 365 GGTIEVESEE-GEGTVFTVRLPKEGE 389
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
236-356 |
1.13e-19 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 83.08 E-value: 1.13e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 236 IDRDATLQVVLNLLKNASEATQEQAdaRITLaTAYRHGMAVapapgkprrplpiEICVIDNGPGPPADIAEHLFDPFISG 315
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGG--RITV-TLERDGDHV-------------EITVEDNGPGIPPEDLEKIFEPFFRT 64
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 739637604 316 KP-----EGQGLGLALVDKLVRDMGGIIQFARE---GappmTVFRILLP 356
Cdd:smart00387 65 DKrsrkiGGTGLGLSIVKKLVELHGGEISVESEpggG----TTFTITLP 109
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
143-360 |
2.66e-18 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 85.99 E-value: 2.66e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLSK------GKGAEELTTLITTEVDRIAALIDRMQDF--TDTRPLKLAPENIYPLLGHAR---R 211
Cdd:COG4251 291 HDLREPLRKISGFSQLLEEdygdklDEEGREYLERIRDAAERMQALIDDLLAYsrVGRQELEFEPVDLNELLEEVLedlE 370
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 212 VALAGFAQHVTIEErfdpsLPSVQIDRDATLQVVLNLLKNASEATQEQADARITLATAYRHGMavapapgkprrplpIEI 291
Cdd:COG4251 371 PRIEERGAEIEVGP-----LPTVRGDPTLLRQVFQNLISNAIKYSRPGEPPRIEIGAEREGGE--------------WVF 431
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 739637604 292 CVIDNGPGPPADIAEHLFDPF----ISGKPEGQGLGLALVDKLVRDMGGIIQFarEGAPPM-TVFRILLPRGDS 360
Cdd:COG4251 432 SVRDNGIGIDPEYAEKIFEIFqrlhSRDEYEGTGIGLAIVKKIVERHGGRIWV--ESEPGEgATFYFTLPKAPA 503
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
143-358 |
6.20e-18 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 85.11 E-value: 6.20e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQL----LSKGKGAEELTTLITTEVDRIAALIDRMQDFTDTRPLKLAPENIYPLLGHAR---RVALA 215
Cdd:PRK13837 459 HNFNNILGAILGYAEMalnkLARHSRAARYIDEIISAGARARLIIDQILAFGRKGERNTKPFDLSELVTEIApllRVSLP 538
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 216 GfaqHVTIEERFDPSLPSVQIDRDATLQVVLNLLKNASEATQEQADARITLATAY-RHGMAVAPAPGKPRRPlpIEICVI 294
Cdd:PRK13837 539 P---GVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKlRAPKVLSHGVLPPGRY--VLLRVS 613
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 739637604 295 DNGPGPPADIAEHLFDPFISGKPEGQGLGLALVDKLVRDMGGIIQFA-REGAPpmTVFRILLPRG 358
Cdd:PRK13837 614 DTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQsTVGRG--TRFDVYLPPS 676
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
237-356 |
5.42e-17 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 75.87 E-value: 5.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 237 DRDATLQVVLNLLKNASEATQEQADARITLATAYRhgmavapapgkprrplpIEICVIDNGPGPPADIAEHLFDPFISG- 315
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGE-----------------LTLTVEDNGIGIPPEDLPRIFEPFSTAd 64
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 739637604 316 --KPEGQGLGLALVDKLVRDMGGIIQFaREGAPPMTVFRILLP 356
Cdd:pfam02518 65 krGGGGTGLGLSIVRKLVELLGGTITV-ESEPGGGTTVTLTLP 106
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
143-358 |
8.97e-17 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 81.04 E-value: 8.97e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLSKGKGAEE---LTTLITTEVDRIAALIDRMQDFTD----TRPLKLAPENIYPLLGH---ARRV 212
Cdd:PRK11100 265 HELKSPLAAIRGAAELLQEDPPPEDrarFTGNILTQSARLQQLIDRLLELARleqrQELEVLEPVALAALLEElveAREA 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 213 ALAgfAQHVTIEERFDPSlpSVQIDRDATLQVVLNLLKNASEATQEQadARITLATAYRHGmavapapgkprrplPIEIC 292
Cdd:PRK11100 345 QAA--AKGITLRLRPDDA--RVLGDPFLLRQALGNLLDNAIDFSPEG--GTITLSAEVDGE--------------QVALS 404
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 739637604 293 VIDNGPGPPaDIA-EHLFDPFIS-----GKPEGQGLGLALVDKLVRDMGGIIQFaREGAPPMTVFRILLPRG 358
Cdd:PRK11100 405 VEDQGPGIP-DYAlPRIFERFYSlprpaNGRKSTGLGLAFVREVARLHGGEVTL-RNRPEGGVLATLTLPRH 474
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
143-356 |
1.72e-16 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 79.91 E-value: 1.72e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLSKGKGAEE----LTTLITTEVDRIAALIDrmqDF-TDTRPlklAPENI--YPLLGHARRVA-- 213
Cdd:COG5806 210 HEVRNPLTVVRGFIQLLQEPELSDEkrkqYIRIALEELDRAEAIIT---DYlTFAKP---QPEKLekIDVSEELEHVIdv 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 214 LAGFA--QHVTIEERFDPSLpSVQIDRDATLQVVLNLLKNASEATQEqaDARITLaTAYRHGmavapapGKprrplpIEI 291
Cdd:COG5806 284 LSPYAnmNNVEIQTELEPGL-YIEGDRQKLQQCLINIIKNGIEAMPN--GGTLTI-DVSIDK-------NK------VII 346
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 739637604 292 CVIDNGPGPPADIAEHLFDPFISGKPEGQGLGLALVDKLVRDMGGIIQFARE---GappmTVFRILLP 356
Cdd:COG5806 347 SIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVESEvgkG----TTFTITLP 410
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
243-355 |
2.59e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 70.95 E-value: 2.59e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 243 QVVLNLLKNASEATQEQADARITLATAYRHGMAVapapgkprrplpieICVIDNGPGPPADIAEHLFDPFISGKP--EGQ 320
Cdd:cd16976 3 QVLMNLLQNALDAMGKVENPRIRIAARRLGGRLV--------------LVVRDNGPGIAEEHLSRVFDPFFTTKPvgKGT 68
|
90 100 110
....*....|....*....|....*....|....*
gi 739637604 321 GLGLALVDKLVRDMGGIIQFAREGaPPMTVFRILL 355
Cdd:cd16976 69 GLGLSISYGIVEEHGGRLSVANEE-GAGARFTFDL 102
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
243-356 |
5.94e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 70.49 E-value: 5.94e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 243 QVVLNLLKNASEATQEqaDARITLATAYRHGMAVAPApgKPRRPLP---IEICVIDNGPGPPADIAEHLFDPFISGKPEG 319
Cdd:cd16919 3 LAILNLAVNARDAMPE--GGRLTIETSNQRVDADYAL--NYRDLIPgnyVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVG 78
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 739637604 320 Q--GLGLALVDKLVRDMGGIIQFARE---GappmTVFRILLP 356
Cdd:cd16919 79 KgtGLGLSMVYGFVKQSGGHLRIYSEpgvG----TTVRIYLP 116
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
243-356 |
5.99e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 70.12 E-value: 5.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 243 QVVLNLLKNASEATQEQADARITLAtayrhgmaVAPAPGKPRRplpIEICVIDNGPGPPADIAEHLFDPFISGKPEGQGL 322
Cdd:cd16920 3 QVLINLVRNGIEAMSEGGCERRELT--------IRTSPADDRA---VTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGM 71
|
90 100 110
....*....|....*....|....*....|....
gi 739637604 323 GLALVDKLVRDMGGIIQFAREGAPPmTVFRILLP 356
Cdd:cd16920 72 GLSICRSIIEAHGGRLSVESPAGGG-ATFQFTLP 104
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
242-357 |
1.48e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 68.99 E-value: 1.48e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 242 LQVVLNLLKNASEATQEQAdaRITLATAYRHGMAVapapgkprrplpieICVIDNGPGPPADIAEHLFDPFISGKP--EG 319
Cdd:cd16943 5 NQVLLNLLVNAAQAMEGRG--RITIRTWAHVDQVL--------------IEVEDTGSGIDPEILGRIFDPFFTTKPvgEG 68
|
90 100 110
....*....|....*....|....*....|....*...
gi 739637604 320 QGLGLALVDKLVRDMGGIIQFAREgAPPMTVFRILLPR 357
Cdd:cd16943 69 TGLGLSLSYRIIQKHGGTIRVASV-PGGGTRFTIILPI 105
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
237-356 |
6.99e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 67.18 E-value: 6.99e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 237 DRDATLQVVLNLLKNASEATQEQADARITLATAYRHGmavapapgkprRPLPIEICVIDNGPGPPADIAEHLFDPFISGK 316
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGRPSDVGEVRIRVEAD-----------QDGRIVLIVCDNGKGFPREMRHRATEPYVTTR 69
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 739637604 317 PEGQGLGLALVDKLVRDMGGIIQFAREGAPPMTVfRILLP 356
Cdd:cd16944 70 PKGTGLGLAIVKKIMEEHGGRISLSNREAGGACI-RIILP 108
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
243-340 |
8.69e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 64.05 E-value: 8.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 243 QVVLNLLKNASEATQEqadARITLATAYRhgmavapapGKPRRPLPIEICVIDNGPGPPADIAEHLFDPF------ISGK 316
Cdd:cd16922 3 QILLNLLGNAIKFTEE---GEVTLRVSLE---------EEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFsqadssTTRK 70
|
90 100
....*....|....*....|....
gi 739637604 317 PEGQGLGLALVDKLVRDMGGIIQF 340
Cdd:cd16922 71 YGGTGLGLAISKKLVELMGGDISV 94
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
217-356 |
1.43e-11 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 65.46 E-value: 1.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 217 FAQHVTIEERFDPSLPSVQIDRDATLQVVLNLLKNASEATQEQAdaRITLATAYRHGMAVAPAPGKPRRP-LPIEICVID 295
Cdd:PRK13557 254 LGDAVTIETDLAPDLWNCRIDPTQAEVALLNVLINARDAMPEGG--RVTIRTRNVEIEDEDLAMYHGLPPgRYVSIAVTD 331
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 739637604 296 NGPGPPADIAEHLFDPFISGKPEGQG--LGLALVDKLVRDMGGIIQFAREGAPPMTVfRILLP 356
Cdd:PRK13557 332 TGSGMPPEILARVMDPFFTTKEEGKGtgLGLSMVYGFAKQSGGAVRIYSEVGEGTTV-RLYFP 393
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
143-341 |
1.80e-10 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 62.40 E-value: 1.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRgaAQLLSKGKGAE-ELTTLITTEVDRIAALIDRM-------QDFTDTRPLKLAPENIYPLLGHARR-VA 213
Cdd:COG4192 442 HELNQPLNAMS--MYLFSAKKALEqENYAQLPTSLDKIEGLIERMdkiikslRQFSRKSDTPLQPVDLRQVIEQAWElVE 519
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 214 LAGFAQHVTIEErfdPSLPSVQIDRDATLQVVLNLLKNASEATQEQADARITLATAYRHgmavapapgkprrplpIEICV 293
Cdd:COG4192 520 SRAKPQQITLHI---PDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAEN----------------LRVAI 580
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 739637604 294 IDNGPGPPadIAEHLFDPFISGKPEGQGLGLALVDKLVRDMGGIIQFA 341
Cdd:COG4192 581 SDNGNGWP--LVDKLFTPFTTTKEVGLGLGLSICRSIMQQFGGDLYLA 626
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-356 |
4.02e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 56.53 E-value: 4.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 244 VVLNLLKNASEATQEQAD--ARITLATAYRHGMAVapapgkprrplpieICVIDNGPGPPADIAEHLFDPFISGKPEG-Q 320
Cdd:cd16915 4 IVGNLIDNALDALAATGApnKQVEVFLRDEGDDLV--------------IEVRDTGPGIAPELRDKVFERGVSTKGQGeR 69
|
90 100 110
....*....|....*....|....*....|....*.
gi 739637604 321 GLGLALVDKLVRDMGGIIqFAREGAPPMTVFRILLP 356
Cdd:cd16915 70 GIGLALVRQSVERLGGSI-TVESEPGGGTTFSIRIP 104
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
244-343 |
6.17e-10 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 60.31 E-value: 6.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 244 VVLNLLKNASEATQEQADARITLATAYRHGMavapapgkprrpLPIEicVIDNGPGPPADIAEHLFDPFISGKPEGQGLG 323
Cdd:PRK11086 437 ILGNLIENALEAVGGEEGGEISVSLHYRNGW------------LHCE--VSDDGPGIAPDEIDAIFDKGYSTKGSNRGVG 502
|
90 100
....*....|....*....|
gi 739637604 324 LALVDKLVRDMGGIIQFARE 343
Cdd:PRK11086 503 LYLVKQSVENLGGSIAVESE 522
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
143-338 |
1.92e-09 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 58.42 E-value: 1.92e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLSKGKgaeelttlITTEVDRIAALIDRMQDFTDTRpLKLAPENIYPLLG-----------HARR 211
Cdd:PRK09303 160 HDLRTPLTAASLALETLELGQ--------IDEDTELKPALIEQLQDQARRQ-LEEIERLITDLLEvgrtrwealrfNPQK 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 212 VALAGFAQHVTIE--ERF---------D-PS-LPSVQIDRDATLQVVLNLLKNASEATQEQadARITLATAYRHGMAVap 278
Cdd:PRK09303 231 LDLGSLCQEVILEleKRWlaksleiqtDiPSdLPSVYADQERIRQVLLNLLDNAIKYTPEG--GTITLSMLHRTTQKV-- 306
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 739637604 279 apgkprrplpiEICVIDNGPGPPADIAEHLFDPFI----SGKPEGQGLGLALVDKLVRDMGGII 338
Cdd:PRK09303 307 -----------QVSICDTGPGIPEEEQERIFEDRVrlprDEGTEGYGIGLSVCRRIVRVHYGQI 359
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
143-190 |
1.95e-09 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 53.37 E-value: 1.95e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 739637604 143 HEIKNPLSGIRGAAQLLSKGKGAEELTTL---ITTEVDRIAALIDRMQDFT 190
Cdd:pfam00512 11 HELRTPLTAIRGYLELLRDEKLDEEQREYletILRSAERLLRLINDLLDLS 61
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
143-189 |
3.84e-08 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 49.49 E-value: 3.84e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLSKGKGAEE---LTTLITTEVDRIAALIDRMQDF 189
Cdd:smart00388 11 HELRTPLTAIRGYLELLLDTELSEEqreYLETILREAERLLRLINDLLDL 60
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
143-190 |
4.46e-08 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 49.52 E-value: 4.46e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 739637604 143 HEIKNPLSGIRGAAQLLSKGKG----AEELTTLITTEVDRIAALIDRMQDFT 190
Cdd:cd00082 13 HELRTPLTAIRGALELLEEELLddeeQREYLERIREEAERLLRLINDLLDLS 64
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
143-331 |
5.07e-08 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 54.15 E-value: 5.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLSKGKG--AEElttlITTEVDRIAALIDRMQDF--TDTRpLKLAPENIYPLLGHarrVALAGFA 218
Cdd:PRK09467 238 HDLRTPLTRIRLATEMMSEEDGylAES----INKDIEECNAIIEQFIDYlrTGQE-MPMEMADLNALLGE---VIAAESG 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 219 QHVTIEERFDPSLPSVQIDRDATLQVVLNLLKNASEATQEqadaRITLATAYRHGMAVapapgkprrplpieICVIDNGP 298
Cdd:PRK09467 310 YEREIETALQPGPIEVPMNPIAIKRALANLVVNAARYGNG----WIKVSSGTEGKRAW--------------FQVEDDGP 371
|
170 180 190
....*....|....*....|....*....|....*...
gi 739637604 299 G-PPADIaEHLFDPFISGK----PEGQGLGLALVDKLV 331
Cdd:PRK09467 372 GiPPEQL-KHLFQPFTRGDsargSSGTGLGLAIVKRIV 408
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
247-356 |
1.35e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 49.25 E-value: 1.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 247 NLLKNASEatqeQADARITLATAYRHGMavapapgkprrplpIEICVIDNGPGPPADIAEHLFDPF------ISGKPEGQ 320
Cdd:cd16949 7 NVLRNALR----YSPSKILLDISQDGDQ--------------WTITITDDGPGVPEDQLEQIFLPFyrvdsaRDRESGGT 68
|
90 100 110
....*....|....*....|....*....|....*.
gi 739637604 321 GLGLALVDKLVRDMGGIIQfAREGAPPMTVFRILLP 356
Cdd:cd16949 69 GLGLAIAERAIEQHGGKIK-ASNRKPGGLRVRIWLP 103
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
14-75 |
1.71e-07 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 47.78 E-value: 1.71e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 739637604 14 PDFAELFAALPVAVLVVDDAGCIVFANAECETLLNLSERAMLGHPLVSVMTPPSQPNARDNH 75
Cdd:smart00091 1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEAL 62
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
237-341 |
1.76e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 49.00 E-value: 1.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 237 DRDATLQVVLNLLKNASEATQEQADARITLAtayrhgmavapapgkpRRPLPIEICVIDNGPGPPADIAEHLFDPFISGK 316
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAA----------------QTPQEVRLDVEDSAPGVSDDQLARLFERFYRVE 64
|
90 100 110
....*....|....*....|....*....|.
gi 739637604 317 PE------GQGLGLALVDKLVRDMGGIIQFA 341
Cdd:cd16946 65 SSrnrasgGSGLGLAICHNIALAHGGTISAE 95
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
143-336 |
2.59e-07 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 52.60 E-value: 2.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLSKGKGAEELTTLITTEVDRIAALIDRMQDFTDTRPLKLAPENIY---------PLLGHARRVA 213
Cdd:PRK11466 453 HEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDSGESLLTILNDILDYSAIEAGGKNVSvsdepfeprPLLESTLQLM 532
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 214 LAGFAQH-VTIEERFDPSLPS-VQIDRDATLQVVLNLLKNASEATqEQADARITLATAYRHGMavapapgkprrplpieI 291
Cdd:PRK11466 533 SGRVKGRpIRLATDIADDLPTaLMGDPRRIRQVITNLLSNALRFT-DEGSIVLRSRTDGEQWL----------------V 595
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 739637604 292 CVIDNGPG-PPADIAEhLFDPFI--SGKPEGQGLGLALVDKLVRDMGG 336
Cdd:PRK11466 596 EVEDSGCGiDPAKLAE-IFQPFVqvSGKRGGTGLGLTISSRLAQAMGG 642
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
143-336 |
8.95e-07 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 50.80 E-value: 8.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLSKGKGAEELTTLITTE---VDRIAALIDRMQDFT--DTRPLKLAPE--NIYPLLGHA-RRVAL 214
Cdd:PRK15347 407 HEIRTPLNGVLGALELLQNTPLTAEQMDLADTArqcTLSLLAIINNLLDFSriESGQMTLSLEetALLPLLDQAmLTIQG 486
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 215 AGFAQHVTIEERFDPSLP-SVQIDRDATLQVVLNLLKNASEATQeqaDARITLaTAYRHGMAVApapgkprrplpieICV 293
Cdd:PRK15347 487 PAQSKSLTLRTFVGAHVPlYLHLDSLRLRQILVNLLGNAVKFTE---TGGIRL-RVKRHEQQLC-------------FTV 549
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 739637604 294 IDNGPGPPADIAEHLFDPF--ISGKPEGQGLGLALVDKLVRDMGG 336
Cdd:PRK15347 550 EDTGCGIDIQQQQQIFTPFyqADTHSQGTGLGLTIASSLAKMMGG 594
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
143-356 |
1.27e-06 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 50.36 E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLL---SKGKGAEELTTLITTEVDRIAALIDRMQDFT--DTRPLKLAPE-------------NIYP 204
Cdd:PRK10841 456 HELRTPLYGIIGNLDLLqtkELPKGVDRLVTAMNNSSSLLLKIISDILDFSkiESEQLKIEPRefsprevinhitaNYLP 535
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 205 LLGHaRRVALAGFaqhvtIEerfdPSLPsVQIDRDAT-LQVVL-NLLKNASEATQEQAdarITLATAYRHGMavapapgk 282
Cdd:PRK10841 536 LVVK-KRLGLYCF-----IE----PDVP-VALNGDPMrLQQVIsNLLSNAIKFTDTGC---IVLHVRVDGDY-------- 593
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 283 prrplpIEICVIDNGPGPPADIAEHLFDPFI---SGK---PEGQGLGLALVDKLVRDMGGIIQFAREgaPPM-TVFRILL 355
Cdd:PRK10841 594 ------LSFRVRDTGVGIPAKEVVRLFDPFFqvgTGVqrnFQGTGLGLAICEKLINMMDGDISVDSE--PGMgSQFTIRI 665
|
.
gi 739637604 356 P 356
Cdd:PRK10841 666 P 666
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
143-356 |
1.34e-06 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 50.50 E-value: 1.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLS-KGKGAEELTTLITTEVDRIAALIDRMQDFTDTRPL-----KLAPENI-YPLLGHARRVALA 215
Cdd:PRK09959 721 HEIRTPISSIMGFLELLSgSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIesgnyQLQPQWVdIPTLVQNTCHSFG 800
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 216 GFAQHVTIEERFDPSLPS---VQIDRDATLQVVLNLLKNASEATQEQAdarITLATAYRH---GMAVapapgkprrplpI 289
Cdd:PRK09959 801 AIAASKSIALSCSSTFPDhylVKIDPQAFKQVLSNLLSNALKFTTEGA---VKITTSLGHiddNHAV------------I 865
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 739637604 290 EICVIDNGPGPPADIAEHLFDPF---ISGKPE-GQGLGLALVDKLVRDMGGiiQFAREGAPPM-TVFRILLP 356
Cdd:PRK09959 866 KMTIMDSGSGLSQEEQQQLFKRYsqtSAGRQQtGSGLGLMICKELIKNMQG--DLSLESHPGIgTTFTITIP 935
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
143-339 |
2.15e-06 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 49.22 E-value: 2.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLSKGKGAEELTtlITTEVDRIAALIDRMqdFTDTR------PLKLAPENIYPLLgharRVALAG 216
Cdd:PRK10604 221 HELRTPLVRLRYRLEMSDNLSAAESQA--LNRDIGQLEALIEEL--LTYARldrpqnELHLSEPDLPAWL----STHLAD 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 217 FaQHVTIEERFDPSLPSVQ----IDRDATLQVVLNLLKNAseatQEQADARITLATAYRHGMAVapapgkprrplpieIC 292
Cdd:PRK10604 293 I-QAVTPEKTVRLDTPHQGdygaLDMRLMERVLDNLLNNA----LRYAHSRVRVSLLLDGNQAC--------------LI 353
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 739637604 293 VIDNGPGPPADIAEHLFDPFISGKPE------GQGLGLALVDKLVRDMGGIIQ 339
Cdd:PRK10604 354 VEDDGPGIPPEERERVFEPFVRLDPSrdratgGCGLGLAIVHSIALAMGGSVN 406
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
289-344 |
2.81e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 45.52 E-value: 2.81e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 739637604 289 IEICVIDNGPGPPADIAEHLFDPFISGKP----EGQGLGLALVDKLVRDMGGIIQFA-REG 344
Cdd:cd16950 31 TRIQVLDNGPGIAPEEVDELFQPFYRGDNargtSGTGLGLAIVQRISDAHGGSLTLAnRAG 91
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
143-331 |
3.89e-06 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 48.04 E-value: 3.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLSKgKGAEELTTLItTEVDRIAALIDRM-------QDFT--DTRPLKLAPENIYPLLGHARRVa 213
Cdd:PRK10755 146 HELRTPLAGIRLHLELLEK-QHHIDVAPLI-ARLDQMMHTVEQLlqlaragQSFSsgHYQTVKLLEDVILPSQDELSEM- 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 214 LAGFAQHVTIEErfDPSLPSVQidRDATL-QVVL-NLLKNASEATQEQADARITLATAyrhgmavapapgkprrPLPIEI 291
Cdd:PRK10755 223 LEQRQQTLLLPE--SAADITVQ--GDATLlRLLLrNLVENAHRYSPEGSTITIKLSQE----------------DGGAVL 282
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 739637604 292 CVIDNGPGPPADIAEHLFDPF--ISGKPEGQGLGLALVDKLV 331
Cdd:PRK10755 283 AVEDEGPGIDESKCGELSKAFvrMDSRYGGIGLGLSIVSRIT 324
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
23-106 |
1.16e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 43.78 E-value: 1.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 23 LPVAVLVVDDAGCIVFANAECETLLNLSERAMLGHPLVSVMTPPSQPNARDNH-----GLAAFDTEIAL--KRGGKIRVD 95
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLenllsGGEPVTLEVRLrrKDGSVIWVL 80
|
90
....*....|.
gi 739637604 96 YIETRVADHPG 106
Cdd:cd00130 81 VSLTPIRDEGG 91
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
143-356 |
1.32e-05 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 46.95 E-value: 1.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLL-----SKG----KGAEELTTLITTEVDRIAALID--RMQdfTDTRPLKLAPENIYPLLGHARR 211
Cdd:PRK10490 673 HDLRTPLTVLFGQAEILtldlaSEGsphaRQASEIRQQVLNTTRLVNNLLDmaRIQ--SGGFNLRKEWLTLEEVVGSALQ 750
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 212 VALAGFAQHvTIEERFDPSLPSVQIDRDATLQVVLNLLKNASEATQEQADARITLATAYRHgmavapapgkprrplpIEI 291
Cdd:PRK10490 751 MLEPGLSGH-PINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGER----------------LQL 813
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 739637604 292 CVIDNGPGPPADIAEHLFDPFISGKPE----GQGLGLALVDKLVRDMGGIIqFAREGAPPMTVFRILLP 356
Cdd:PRK10490 814 DVWDNGPGIPPGQEQLIFDKFARGNKEsaipGVGLGLAICRAIVEVHGGTI-WAENRPEGGACFRVTLP 881
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
244-336 |
1.51e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 43.57 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 244 VVLNLLKNAseatQEQADARITLATAYRHGMAVapapgkprrplpieICVIDNGPGPPADIAEHLFDPFISGKPE----- 318
Cdd:cd16939 4 ALDNLLRNA----LRYAHRTVRIALLVSGGRLT--------------LIVEDDGPGIPAAARERVFEPFVRLDPSrdrat 65
|
90
....*....|....*....
gi 739637604 319 -GQGLGLALVDKLVRDMGG 336
Cdd:cd16939 66 gGFGLGLAIVHRVALWHGG 84
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
237-338 |
3.91e-05 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 42.48 E-value: 3.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 237 DRDATLQVVLNLLKNASEATQEQADARITLATAyrhgmavapapgkprRPLPIEICVIDNGPGPPADIAEHLFDPFISGK 316
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKF---------------RLNRFLLTVSDSGPGIPPNLREEIFERFRQGD 65
|
90 100
....*....|....*....|....*...
gi 739637604 317 PEGQ------GLGLALVDKLVRDMGGII 338
Cdd:cd16925 66 GSSTrahggtGLGLSIVKEFVELHGGTV 93
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
15-67 |
5.57e-05 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 42.02 E-value: 5.57e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 739637604 15 DFAELFAALPVAVLVVDDAGCIVFANAECETLLNLSERAMLGHPLVSVMTPPS 67
Cdd:pfam00989 2 DLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEED 54
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
16-111 |
5.78e-05 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 44.25 E-value: 5.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 16 FAELFAALPVAVLVVDDAGCIVFANAECETLLNLSERAMLGHPLVSVMTPPSQPNARDN------HGLAAFDTEIALKRG 89
Cdd:COG2202 139 LRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELlrrlleGGRESYELELRLKDG 218
|
90 100
....*....|....*....|..
gi 739637604 90 GKIRVdYIETRVADHPGWHTIT 111
Cdd:COG2202 219 DGRWV-WVEASAVPLRDGGEVI 239
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
243-338 |
7.08e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 41.54 E-value: 7.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 243 QVVLNLLKNASEATQEQADARITLatayrhgmavapapGKPRRPLPIEICVIDNGPGPPADIAEHLFDPF----ISGKPE 318
Cdd:cd16921 3 QVLTNLLGNAIKFRRPRRPPRIEV--------------GAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFqrlhSREEYE 68
|
90 100
....*....|....*....|
gi 739637604 319 GQGLGLALVDKLVRDMGGII 338
Cdd:cd16921 69 GTGVGLAIVRKIIERHGGRI 88
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
289-359 |
2.10e-04 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 42.97 E-value: 2.10e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 739637604 289 IEICVIDNGPGPPADIAEhlfdpfisgkPEGQGLGLALVDKLVRDMGGIIQFARegaPPMTVFRILLPRGD 359
Cdd:COG3920 435 LRLTVSDNGVGLPEDVDP----------PARKGLGLRLIRALVRQLGGTLELDR---PEGTRVRITFPLAE 492
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
20-94 |
3.07e-04 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 39.70 E-value: 3.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 20 FAALPVAVLVVDDAGCIVFANAECETLLNLSERAMLGHPLVSVMTPPSQPNARDN-----HGLAAFDTEIALKRGGKIRV 94
Cdd:pfam08448 1 LDSLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLPPEDAARLERAlrralEGEEPIDFLEELLLNGEERH 80
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
143-340 |
3.36e-04 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 42.53 E-value: 3.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLSKgkgaeelTTLITTEVD------RIA----ALIDRMQDFTDTRPLKLAPENIyPllgharrv 212
Cdd:PRK11107 302 HELRTPLNGVIGFTRQTLK-------TPLTPTQRDylqtieRSAnnllAIINDILDFSKLEAGKLVLENI-P-------- 365
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 213 alagFAQHVTIEE------------------RFDPSLPSvQIDRDATL--QVVLNLLKNA-----------SEATQEQAD 261
Cdd:PRK11107 366 ----FSLRETLDEvvtllahsahekgleltlNIDPDVPD-NVIGDPLRlqQIITNLVGNAikftesgnidiLVELRALSN 440
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 262 ARITLatayrhgmavapapgkprrplpiEICVIDNGPGPPADIAEHLFDPF------ISGKPEGQGLGLALVDKLVRDMG 335
Cdd:PRK11107 441 TKVQL-----------------------EVQIRDTGIGISERQQSQLFQAFrqadasISRRHGGTGLGLVITQKLVNEMG 497
|
....*
gi 739637604 336 GIIQF 340
Cdd:PRK11107 498 GDISF 502
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
220-340 |
3.64e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 40.31 E-value: 3.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 220 HVTIEERFDPSLpSVQIDRDATLQVVLNLLKNASEATQEQAdaRITLAtayrhgmavaPAPGKprrplpIEICVIDNGPG 299
Cdd:cd16954 18 GVSISLDISPEL-RFPGERNDLMELLGNLLDNACKWCLEFV--EVTAR----------QTDGG------LHLIVDDDGPG 78
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 739637604 300 PPADIAEHLFDPFISGKPE--GQGLGLALVDKLVRDMGGIIQF 340
Cdd:cd16954 79 VPESQRSKIFQRGQRLDEQrpGQGLGLAIAKEIVEQYGGELSL 121
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
242-356 |
5.32e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 38.91 E-value: 5.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 242 LQVVL-NLLKNASEATQEQADARITlatAYRHGMAVapapgkprrplpiEICVIDNGPGPPADIAEHLFDPF----ISGK 316
Cdd:cd16923 1 LQRVFsNLLSNAIKYSPENTRIYIT---SFLTDDVV-------------NIMFKNPSSHPLDFKLEKLFERFyrgdNSRN 64
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 739637604 317 PEGQGLGLALVDKLVRDMGGiiQFAREGAPPMTVFRILLP 356
Cdd:cd16923 65 TEGAGLGLSIAKAIIELHGG--SASAEYDDNHDLFKVRLP 102
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
143-339 |
9.96e-04 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 41.08 E-value: 9.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQ-LLSKGKGAEELTTLITTEVDRIAA------LIDrmQDFTDTRPLKLAP------------ENIY 203
Cdd:PRK11091 292 HELRTPLNGIVGLSRiLLDTELTAEQRKYLKTIHVSAITLgnifndIID--MDKMERRKLQLDNqpidftdfladlENLS 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 204 PLLgharrvalagfAQHVTIEERFDPSLP---SVQIDRDATLQVVLNLLKNASEATQEqadARITLATAYRHGmavapap 280
Cdd:PRK11091 370 GLQ-----------AEQKGLRFDLEPLLPlphKVITDGTRLRQILWNLISNAVKFTQQ---GGVTVRVRYEEG------- 428
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 739637604 281 gkprrplpIEIC--VIDNGPGPPADIAEHLFDPFIS------GKPE-GQGLGLALVDKLVRDMGGIIQ 339
Cdd:PRK11091 429 --------DMLTfeVEDSGIGIPEDELDKIFAMYYQvkdshgGKPAtGTGIGLAVSKRLAQAMGGDIT 488
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
143-338 |
1.11e-03 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 40.77 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 143 HEIKNPLSGIRGAAQLLSKG---KGAEELTTLiTTEVDRIAALIDRMQDFTDTRPLKLA----PENIYPLLgharRVALA 215
Cdd:PRK10549 249 HELRTPLAVLRGELEAIQDGvrkFTPESVASL-QAEVGTLTKLVDDLHQLSLSDEGALAyrktPVDLVPLL----EVAGG 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 216 GF-----AQHVTIEERFDPSLPsVQIDRDATLQVVLNLLKNASEATQEQADARITlaTAYRHGMAVapapgkprrplpie 290
Cdd:PRK10549 324 AFrerfaSRGLTLQLSLPDSAT-VFGDPDRLMQLFNNLLENSLRYTDSGGSLHIS--AEQRDKTLR-------------- 386
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 739637604 291 ICVIDNGPGPPADIAEHLFDPFI---------SGkpeGQGLGLALVDKLVRDMGGII 338
Cdd:PRK10549 387 LTFADSAPGVSDEQLQKLFERFYrtegsrnraSG---GSGLGLAICLNIVEAHNGRI 440
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
217-355 |
2.45e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 37.49 E-value: 2.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 217 FAQHVTIEERfdpsLPSVQIDRDATLQVVLNLLKNAseaTQEQADAR---ITLATAYRHgmavapapgkprrplpIEICV 293
Cdd:cd16947 1 FQVEINIPDR----PIYANANTEALQRILKNLISNA---IKYGSDGKflgMTLREDEKH----------------VYIDI 57
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 739637604 294 IDNGPGPPADIAEHLFDPFISGKP------EGQGLGLALVDKLVRDMGGIIQFarEGAP-PMTVFRILL 355
Cdd:cd16947 58 WDKGKGISETEKDHVFERLYTLEDsrnsakQGNGLGLTITKRLAESMGGSIYV--NSKPyEKTVFTVTL 124
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
289-339 |
2.80e-03 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 39.53 E-value: 2.80e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 289 IEICVIDNGPGPPADIAEHLFDPFI---------SGkpeGQGLGLALVDKLVRDMGGIIQ 339
Cdd:PRK09470 384 LTITVDDDGPGVPEEEREQIFRPFYrvdeardreSG---GTGLGLAIVENAIQQHRGWVK 440
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
243-338 |
3.30e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 36.78 E-value: 3.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 243 QVVLNLLKNAseatqeqadarITLATAYRHGMAVAPAPGKPRrplpIEICVIDNGPGPPADIAEHLFDPFISGKPEGQ-- 320
Cdd:cd16953 3 QVLRNLIGNA-----------ISFSPPDTGRITVSAMPTGKM----VTISVEDEGPGIPQEKLESIFDRFYTERPANEaf 67
|
90 100
....*....|....*....|..
gi 739637604 321 ----GLGLALVDKLVRDMGGII 338
Cdd:cd16953 68 gqhsGLGLSISRQIIEAHGGIS 89
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
243-341 |
3.82e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 36.67 E-value: 3.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739637604 243 QVVLNLLKNASEATQEQADARITLATAYRHgmavapapgkprrplpIEICVIDNGPGPPADIAEHLFDPFIS-GKPEGQ- 320
Cdd:cd16945 7 QAINNLLDNAIDFSPEGGLIALQLEADTEG----------------IELLVFDEGSGIPDYALNRVFERFYSlPRPHSGq 70
|
90 100
....*....|....*....|....
gi 739637604 321 ---GLGLALVDKLVRDMGGIIQFA 341
Cdd:cd16945 71 kstGLGLAFVQEVAQLHGGRITLR 94
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
16-66 |
3.88e-03 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 35.60 E-value: 3.88e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 739637604 16 FAELFAALPVAVLVVDDAGCIVFANAECETLLNLSERAMLGHPLVSVMTPP 66
Cdd:pfam13188 3 LRALFESSPDGILVLDEGGRIIYVNPAALELLGYELLGELLGELLDLLDPL 53
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
16-62 |
4.60e-03 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 38.60 E-value: 4.60e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 739637604 16 FAELFAALPVAVLVVDDAGCIVFANAECETLLNLSERAMLGHPLVSV 62
Cdd:COG3829 13 LEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTEL 59
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
289-335 |
7.66e-03 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 36.04 E-value: 7.66e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 739637604 289 IEICVIDNGPG-PPADIAEHlfdpfISGKPEGqGLGLALVDKLVRDMG 335
Cdd:COG2172 70 LEIEVRDEGPGfDPEDLPDP-----YSTLAEG-GRGLFLIRRLMDEVE 111
|
|
| |
