|
Name |
Accession |
Description |
Interval |
E-value |
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
266-490 |
1.52e-38 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 140.81 E-value: 1.52e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 266 AVDAMADTLQQRIEAERRVTADIAHELRTPVTGLLTAAELL--PPGRPTE-------LVLDRAKAMRTLVEDVLEVARLD 336
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLldEEDLSPEerrelleIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 337 GASERAELQDIMLGHFVSR-----RVAAKDPAVTVRVVHESE---VTTDPRRLERVLFNLLANAARHGRP--PIEVSVEG 406
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEaveelRPLAEEKGIRLELDLPPElplVYADPELLEQVLANLLDNAIKYSPPggTITISARR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 407 R----VIRVRDHGPGFPQHLIAEGPSRFRTGSRDRAGRGHGLGLTIAAGQARVLGARLTFRNvrpagaapdEPAEGAVAV 482
Cdd:COG2205 161 EgdgvRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVES---------EPGGGTTFT 231
|
....*...
gi 739915594 483 LWLPEHAP 490
Cdd:COG2205 232 VTLPLAES 239
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
209-489 |
4.60e-27 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 114.35 E-value: 4.60e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 209 AVVLGGSALGVLIGG-------QLSRRLREAAAAANQVANGEPDVRvrdaIGGVVRDETDDVARAVDAMADTLQQRI--- 278
Cdd:NF040691 189 TLLLGGLALVVLLGLiawlvtrQVVAPVRSAARTAERFAAGDLSER----MPVKGEDDLARLARSFNQMADSLQRQIrql 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 279 ----EAERRVTADIAHELRTPVTGLLTAAEL-------LPPG--RPTELVLDRAKAMRTLVEDVLEVARLDGASERAELQ 345
Cdd:NF040691 265 eelsRLQQRFVSDVSHELRTPLTTIRMAADVihdsrddFDPAtaRSAELLHTELDRFESLLSDLLEISRFDAGAAELDVE 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 346 DIMLGHFVSRRVA-----AKDPAVTVRVVHESE---VTTDPRRLERVLFNLLANAARHGR-PPIEVSV---EGRV-IRVR 412
Cdd:NF040691 345 PVDLRPLVRRVVDalrqlAERAGVELRVDAPGTpvvAEVDPRRVERVLRNLVVNAIEHGEgKPVVVTVaqdDTAVaVTVR 424
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 739915594 413 DHGPGFPQHLIAEGPSRFRTG--SRDRAGRGHGLGLTIAAGQARVLGARLTfrnvrpagaAPDEPAEGAVAVLWLPEHA 489
Cdd:NF040691 425 DHGVGLKPGEVALVFDRFWRAdpARARTTGGTGLGLAIALEDARLHGGWLE---------AWGRPGQGSQFRLTLPRVA 494
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
209-489 |
4.12e-24 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 105.31 E-value: 4.12e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 209 AVVLGGSAL-GVLIGGQLSRRLREAAAAANQVANGEPdVRVRDAIGGvvrdETDDVARAVDAMADTLQQRIEAERRVTAd 287
Cdd:PRK11100 189 ALLLGIALLiGAGVVWWLNRSIRRLTRYADAVTEGKP-VPLPKLGSS----ELRELAQALESMRVKLEGKAYVEQYVQT- 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 288 IAHELRTPVTGLLTAAELLPPGRPTEL-------VLDRAKAMRTLVEDVLEVARLDGASERAELQDIMLGHFVSRRVAAK 360
Cdd:PRK11100 263 LTHELKSPLAAIRGAAELLQEDPPPEDrarftgnILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAR 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 361 DPA-----VTVRV-VHESEVTTDPRRLERVLFNLLANA----ARHGRppIEVSVEGR----VIRVRDHGPGFPQHLIAEG 426
Cdd:PRK11100 343 EAQaaakgITLRLrPDDARVLGDPFLLRQALGNLLDNAidfsPEGGT--ITLSAEVDgeqvALSVEDQGPGIPDYALPRI 420
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 739915594 427 PSRFRTGSRDRAGR-GHGLGLTIAAGQARVLGARLTFRNvRPAGaapdepaeGAVAVLWLPEHA 489
Cdd:PRK11100 421 FERFYSLPRPANGRkSTGLGLAFVREVARLHGGEVTLRN-RPEG--------GVLATLTLPRHF 475
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
75-448 |
9.91e-19 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 88.60 E-value: 9.91e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 75 LRWKLSAAIALVGALVAVALSLVVHNA--------------ARVSM----LDNARDLADDRV--------------LIAQ 122
Cdd:TIGR01386 4 LTLRLALLFAAVTALVFALSGFMLYSSlerhfeerdreelqGKLEQvrrfLRDPADLDEDIKrlqekiddllvghsDLAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 123 RNYELSGRQNFPNAKIDDPALPPELRRKTEAGRRATYVSERADGVTDIWAAVPLKDGHVMSLHSGFTDRSAD--ILHDLD 200
Cdd:TIGR01386 84 SILNPDGRLLFERAQGAALVPAVAANDALLELDQADAKMTHYRSILRSVAALPGGKGRKPVQITVALDINAHthLLDALR 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 201 QALVIGSIAVVLGGSALGVLIGGQLSRRLREAAAAANQVANGEPDVRVRDAiggVVRDETDDVARAVDAMADTLQQRIEA 280
Cdd:TIGR01386 164 KWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPS---RAPAELRELAQSFNAMLGRLEDAFQR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 281 ERRVTADIAHELRTPVTGLLTAAE--LLPPGRPTELV------LDRAKAMRTLVEDVLEVARLDGASERAELQDIMLGHF 352
Cdd:TIGR01386 241 LSQFSADLAHELRTPLTNLLGQTQvaLSQPRTGEEYRevlesnLEELERLSRMVSDMLFLARADNGQLALERVRLDLAAE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 353 VSRRVA-----AKDPAVTVRVVHESEVTTDPRRLERVLFNLLANAARHGRP--PIEVSVEGRV----IRVRDHGPGFPQH 421
Cdd:TIGR01386 321 LAKVAEyfeplAEERGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDggTITVRIERRSdevrVSVSNPGPGIPPE 400
|
410 420
....*....|....*....|....*....
gi 739915594 422 LIAEGPSRF--RTGSRDRAGRGHGLGLTI 448
Cdd:TIGR01386 401 HLSRLFDRFyrVDPARSNSGEGTGLGLAI 429
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
381-485 |
1.26e-18 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 81.11 E-value: 1.26e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 381 LERVLFNLLANAARHGRP--PIEVSV----EGRVIRVRDHGPGFPQHLIAEGPSRFRTGSRDRAGRGHGLGLTIAAGQAR 454
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPggTIEISLrqegDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80
|
90 100 110
....*....|....*....|....*....|.
gi 739915594 455 VLGARLTFRNvrpagaapdEPAEGAVAVLWL 485
Cdd:cd00075 81 AHGGRITVES---------EPGGGTTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
376-486 |
3.29e-18 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 80.00 E-value: 3.29e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 376 TDPRRLERVLFNLLANAARHGRPPIEVSVEGR------VIRVRDHGPGFPQHLIAEGPSRF-RTGSRDRAGRGHGLGLTI 448
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLErdgdhvEITVEDNGPGIPPEDLEKIFEPFfRTDKRSRKIGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|....*...
gi 739915594 449 AAGQARVLGARLTFRNvrpagaapdEPAEGAVAVLWLP 486
Cdd:smart00387 81 VKKLVELHGGEISVES---------EPGGGTTFTITLP 109
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
34-449 |
7.73e-18 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 86.38 E-value: 7.73e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 34 EPGGRFASRGPGETTGPTGLTGPARPTGLRRLLRGRSIRTGLRWKLSAAIALVGALVAVALSLVVHNAARVSMLDNARDL 113
Cdd:COG4251 26 LVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 114 ADDRVLIAQRNYELSGRQNFPNAKIDDPALPPELRRKTEAGRRATYVSERADGVTD--IWAAVPLKDGHVMSLHSGFTDR 191
Cdd:COG4251 106 LLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLllLALILALLLAALAELELLLLLL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 192 SADILHDLDQALVIGSIAVVLGGSALGVLIGGQLSRRLREAAAAANQVANGEPDVRVRDAIGGVVRDETDDVARAVDAMA 271
Cdd:COG4251 186 LVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELE 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 272 DTLQQRIEAERRVTAD-------IAHELRTPVTGLLTAAELL---PPGRPTE-------LVLDRAKAMRTLVEDVLEVAR 334
Cdd:COG4251 266 EELEERTAELERSNEEleqfayvASHDLREPLRKISGFSQLLeedYGDKLDEegreyleRIRDAAERMQALIDDLLAYSR 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 335 LDgaSERAELQDIMLGHFVSR-----RVAAKDPAVTVRVVHESEVTTDPRRLERVLFNLLANAARHGR----PPIEVSVE 405
Cdd:COG4251 346 VG--RQELEFEPVDLNELLEEvledlEPRIEERGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRpgepPRIEIGAE 423
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 739915594 406 ----GRVIRVRDHGPGF-PQHLiaegpSR----FRTGSRDRAGRGHGLGLTIA 449
Cdd:COG4251 424 reggEWVFSVRDNGIGIdPEYA-----EKifeiFQRLHSRDEYEGTGIGLAIV 471
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
376-487 |
2.69e-16 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 74.71 E-value: 2.69e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 376 TDPRRLERVLFNLLANAARHGRPP----IEVSVEGRV-IRVRDHGPGFPQHLIAEGPSRFRTGSRdRAGRGHGLGLTIAA 450
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAgeitVTLSEGGELtLTVEDNGIGIPPEDLPRIFEPFSTADK-RGGGGTGLGLSIVR 79
|
90 100 110
....*....|....*....|....*....|....*..
gi 739915594 451 GQARVLGARLTFRNvrpagaapdEPAEGAVAVLWLPE 487
Cdd:pfam02518 80 KLVELLGGTITVES---------EPGGGTTVTLTLPL 107
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
276-448 |
2.40e-15 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 77.25 E-value: 2.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 276 QRIEAERR-VTADIAHELRTPVTGL------LTAAELLPP---GRPTELVLDRAKAMRTLVEDVLEVARLDGASERAELQ 345
Cdd:TIGR02966 108 RRLEQMRRdFVANVSHELRTPLTVLrgyletLADGPDEDPeewNRALEIMLEQSQRMQSLVEDLLTLSRLESAASPLEDE 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 346 ----DIMLGHFVSRRVAA---KDPAVTVRVVHESEVTTDPRRLERVLFNLLANAARHGRPPIEVSV------EGRVIRVR 412
Cdd:TIGR02966 188 pvdmPALLDHLRDEAEALsqgKNHQITFEIDGGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVrwrrdgGGAEFSVT 267
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 739915594 413 DHGPGF-PQHL--IAEgpsRF----RTGSRDRAgrGHGLGLTI 448
Cdd:TIGR02966 268 DTGIGIaPEHLprLTE---RFyrvdKSRSRDTG--GTGLGLAI 305
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
191-462 |
1.64e-12 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 69.47 E-value: 1.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 191 RSADILHDLDQ---ALVIGSIAVVLGGSAlGVLIGGQLSRRLREAAAAANQVANGEPDVRVRDAIGgvvrDETDDVARAV 267
Cdd:NF012163 152 RNTDINFDSQQkraSWLIVALALLLAALA-AFLLARGLLAPVKRLVEATHRLAAGDYTTRVTPTSN----DELGKLAQDF 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 268 DAMADTLQQRIEAERRVTADIAHELRTPVTGLLTAAELLPPG-RP--TELVLDRAKAMRTLVEDVLEVARLDGASERA-- 342
Cdd:NF012163 227 NQLASTLEKNEQMRRDFMADISHELRTPLAVLRAELEAIQDGiRKftPESLDSLQAEVGTLTKLVDDLHDLSMSDEGAla 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 343 ---------ELQDIMLGHFvSRRVAAKDPAVTVRVVHESEVTTDPRRLERVLFNLLANAARH----GRPPIEVSVEGR-- 407
Cdd:NF012163 307 yqkasvdlvPLLEVEGGAF-RERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYtdsgGSLHISASQRPKev 385
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 739915594 408 VIRVRDHGPGFPQHLIAEGPSRF-RT-GSRDRAGRGHGLGLTIAAGQARVLGARLTF 462
Cdd:NF012163 386 TLTVADSAPGVSDEQLARLFERFyRVeVSRNRASGGSGLGLAISLNIVQAHGGTLHA 442
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
209-448 |
9.29e-11 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 63.48 E-value: 9.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 209 AVVLGGSALGVLIGGQLSRR----LREAAAAANQVANGEPDVRVRDAiggvvRDETDDVARAVD---AMADTLQQRIEAE 281
Cdd:NF012226 64 TVILCGSVISLIIGMKLAQRfivpINFLADAAKKISQGDLSARAEDS-----QIHSAEISELMHnfnDMAQKLESSVKNA 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 282 RRVTADIAHELRTPVT-----------GLLTAAELLppgrpTELVLDRAKAMRTLVEDV--LEVA-----RLDgaSERAE 343
Cdd:NF012226 139 QVWNAAIAHELRTPITilqgrlqgildGVFEPDPAL-----FKSLLNQVEGLSHLVEDLrtLSLVenqqlRLN--YESVD 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 344 LQDIM---LGHFVSRRVAAKdpAVTVRVVHESEVTTDPRRLERVLFNLLANAARH---GRPPIEVSV--EGRVIRVRDHG 415
Cdd:NF012226 212 LKDSIekvLKMFEDRLEQAQ--LTIVLNLTATPVFCDRRRIEQVLIALIDNAIRYanaGKLKISSSViqDDWILQIEDEG 289
|
250 260 270
....*....|....*....|....*....|....*.
gi 739915594 416 PGFPQHLIAE--GPSrFR-TGSRDRAGRGHGLGLTI 448
Cdd:NF012226 290 PGIAEEYQQDlfNPF-FRlEQSRNKEFGGTGLGLAV 324
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
273-449 |
1.77e-06 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 50.52 E-value: 1.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 273 TLQQRIEAERR--VtADIAHELRTPVT-----------GLLTAAELLPpgRPTELVLDRAKAMRTLVEDVLEVARLDGAS 339
Cdd:NF033092 363 TEQEKIEQERRefV-ANVSHELRTPLTtmrsylealadGAWKDPELAP--RFLGVTQNETERMIRLVNDLLQLSRMDSKD 439
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 340 ERAELQDI---MLGHFVSRR--VAAKDPAVTVRVVHESE---VTTDPRRLERVLFNLLANAARH----GRppIEVSV--- 404
Cdd:NF033092 440 YKLNKEWVnfnEFFNYIIDRfeMILKNKNITFKREFPKRdlwVEIDTDKITQVLDNIISNAIKYspegGT--ITFRLlet 517
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 739915594 405 EGRV-IRVRDHGPGFPQHLIAEGPSRF-RTG-SRDRAGRGHGLGLTIA 449
Cdd:NF033092 518 HNRIiISISDQGLGIPKKDLDKIFDRFyRVDkARSRKMGGTGLGLAIA 565
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
224-279 |
4.78e-03 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 35.30 E-value: 4.78e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 739915594 224 QLSRRLREAAAAANQVANGEPDVRVRDAiggvVRDETDDVARAVDAMADTLQQRIE 279
Cdd:smart00304 2 RLLRPLRRLAEAAQRIADGDLTVRLPVD----GRDEIGELARAFNEMADRLEETIA 53
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
266-490 |
1.52e-38 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 140.81 E-value: 1.52e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 266 AVDAMADTLQQRIEAERRVTADIAHELRTPVTGLLTAAELL--PPGRPTE-------LVLDRAKAMRTLVEDVLEVARLD 336
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLldEEDLSPEerrelleIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 337 GASERAELQDIMLGHFVSR-----RVAAKDPAVTVRVVHESE---VTTDPRRLERVLFNLLANAARHGRP--PIEVSVEG 406
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEaveelRPLAEEKGIRLELDLPPElplVYADPELLEQVLANLLDNAIKYSPPggTITISARR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 407 R----VIRVRDHGPGFPQHLIAEGPSRFRTGSRDRAGRGHGLGLTIAAGQARVLGARLTFRNvrpagaapdEPAEGAVAV 482
Cdd:COG2205 161 EgdgvRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVES---------EPGGGTTFT 231
|
....*...
gi 739915594 483 LWLPEHAP 490
Cdd:COG2205 232 VTLPLAES 239
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
191-486 |
4.67e-38 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 142.35 E-value: 4.67e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 191 RSADILHDLDQALVIGSIAVVLGGSALGVLIGGQLSRRLREAAAAANQVANGEPDVRVRDAIGGVVRDETDDVARAVDAM 270
Cdd:COG0642 20 LALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLAL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 271 ADTLQQRIEAERRVTADIAHELRTPVTGLLTAAELLPPGRPTEL------VLDRAKAMRTLVEDVLEVARLDGASERAEL 344
Cdd:COG0642 100 LLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQreyletILRSADRLLRLINDLLDLSRLEAGKLELEP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 345 QDIMLGHFVSR-----RVAAKDPAVTVRVVHESE---VTTDPRRLERVLFNLLANAARHGRP--PIEVSVEGR----VIR 410
Cdd:COG0642 180 EPVDLAELLEEvvelfRPLAEEKGIELELDLPDDlptVRGDPDRLRQVLLNLLSNAIKYTPEggTVTVSVRREgdrvRIS 259
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 739915594 411 VRDHGPGFPQHLIAEGPSRFRTGSRDRAGRGHGLGLTIAAGQARVLGARLTFRNvrpagaapdEPAEGAVAVLWLP 486
Cdd:COG0642 260 VEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVES---------EPGKGTTFTVTLP 326
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
190-486 |
7.18e-32 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 126.59 E-value: 7.18e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 190 DRSADILHDLDQALVIGSIAVVLGGSALGVLIGGQLSRRLREAAAAANQVANGEPDVRVRDAIGGVVRDETDDVARAVDA 269
Cdd:COG5002 74 LLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVER 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 270 MADTLQQRIEAERRVTADIAHELRTPVTGLLTAAELL--PPGRPTELV---LDRAKA----MRTLVEDVLEVARLDGASE 340
Cdd:COG5002 154 DITELERLEQMRREFVANVSHELRTPLTSIRGYLELLldGAADDPEERreyLEIILEeaerLSRLVNDLLDLSRLESGEL 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 341 RAELQDIMLGHFVSR-----RVAAKDPAVTVRVVHESE---VTTDPRRLERVLFNLLANAARHGRP--PIEVSVEGR--- 407
Cdd:COG5002 234 KLEKEPVDLAELLEEvveelRPLAEEKGIELELDLPEDpllVLGDPDRLEQVLTNLLDNAIKYTPEggTITVSLREEddq 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 408 -VIRVRDHGPGFPQ-HL--IAEgpsRFRTG--SRDRAGRGHGLGLTIAAGQARVLGARLTFRNvrpagaapdEPAEGAVA 481
Cdd:COG5002 314 vRISVRDTGIGIPEeDLprIFE---RFYRVdkSRSRETGGTGLGLAIVKHIVEAHGGRIWVES---------EPGKGTTF 381
|
....*
gi 739915594 482 VLWLP 486
Cdd:COG5002 382 TITLP 386
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
209-489 |
4.60e-27 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 114.35 E-value: 4.60e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 209 AVVLGGSALGVLIGG-------QLSRRLREAAAAANQVANGEPDVRvrdaIGGVVRDETDDVARAVDAMADTLQQRI--- 278
Cdd:NF040691 189 TLLLGGLALVVLLGLiawlvtrQVVAPVRSAARTAERFAAGDLSER----MPVKGEDDLARLARSFNQMADSLQRQIrql 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 279 ----EAERRVTADIAHELRTPVTGLLTAAEL-------LPPG--RPTELVLDRAKAMRTLVEDVLEVARLDGASERAELQ 345
Cdd:NF040691 265 eelsRLQQRFVSDVSHELRTPLTTIRMAADVihdsrddFDPAtaRSAELLHTELDRFESLLSDLLEISRFDAGAAELDVE 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 346 DIMLGHFVSRRVA-----AKDPAVTVRVVHESE---VTTDPRRLERVLFNLLANAARHGR-PPIEVSV---EGRV-IRVR 412
Cdd:NF040691 345 PVDLRPLVRRVVDalrqlAERAGVELRVDAPGTpvvAEVDPRRVERVLRNLVVNAIEHGEgKPVVVTVaqdDTAVaVTVR 424
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 739915594 413 DHGPGFPQHLIAEGPSRFRTG--SRDRAGRGHGLGLTIAAGQARVLGARLTfrnvrpagaAPDEPAEGAVAVLWLPEHA 489
Cdd:NF040691 425 DHGVGLKPGEVALVFDRFWRAdpARARTTGGTGLGLAIALEDARLHGGWLE---------AWGRPGQGSQFRLTLPRVA 494
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
209-489 |
4.12e-24 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 105.31 E-value: 4.12e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 209 AVVLGGSAL-GVLIGGQLSRRLREAAAAANQVANGEPdVRVRDAIGGvvrdETDDVARAVDAMADTLQQRIEAERRVTAd 287
Cdd:PRK11100 189 ALLLGIALLiGAGVVWWLNRSIRRLTRYADAVTEGKP-VPLPKLGSS----ELRELAQALESMRVKLEGKAYVEQYVQT- 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 288 IAHELRTPVTGLLTAAELLPPGRPTEL-------VLDRAKAMRTLVEDVLEVARLDGASERAELQDIMLGHFVSRRVAAK 360
Cdd:PRK11100 263 LTHELKSPLAAIRGAAELLQEDPPPEDrarftgnILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAR 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 361 DPA-----VTVRV-VHESEVTTDPRRLERVLFNLLANA----ARHGRppIEVSVEGR----VIRVRDHGPGFPQHLIAEG 426
Cdd:PRK11100 343 EAQaaakgITLRLrPDDARVLGDPFLLRQALGNLLDNAidfsPEGGT--ITLSAEVDgeqvALSVEDQGPGIPDYALPRI 420
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 739915594 427 PSRFRTGSRDRAGR-GHGLGLTIAAGQARVLGARLTFRNvRPAGaapdepaeGAVAVLWLPEHA 489
Cdd:PRK11100 421 FERFYSLPRPANGRkSTGLGLAFVREVARLHGGEVTLRN-RPEG--------GVLATLTLPRHF 475
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
261-491 |
2.06e-22 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 99.65 E-value: 2.06e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 261 DDVARAVDAmadtlqQRIEAERRVTADIAHELRTPVTGLLTAAELL--------PPGRP-----TELVLDRAKAMRTLVE 327
Cdd:COG5000 187 DDITELLRA------ERLAAWGELARRIAHEIKNPLTPIQLSAERLrrkladklEEDREdleraLDTIIRQVDRLKRIVD 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 328 DVLEVARLdgasERAELQDIMLGHFVSR-----RVAAKDPAVTVRVVHESE---VTTDPRRLERVLFNLLANA--ARHGR 397
Cdd:COG5000 261 EFLDFARL----PEPQLEPVDLNELLREvlalyEPALKEKDIRLELDLDPDlpeVLADRDQLEQVLINLLKNAieAIEEG 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 398 PPIEVSV---EGRV-IRVRDHGPGFPQHLiaegpsrfrtgsRDRA--------GRGHGLGLTIAAGQARVLGARLTFRNv 465
Cdd:COG5000 337 GEIEVSTrreDGRVrIEVSDNGPGIPEEV------------LERIfepffttkPKGTGLGLAIVKKIVEEHGGTIELES- 403
|
250 260
....*....|....*....|....*.
gi 739915594 466 rpagaapdEPAEGAVAVLWLPEHAPT 491
Cdd:COG5000 404 --------RPGGGTTFTIRLPLAEEA 421
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
155-488 |
5.55e-22 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 97.56 E-value: 5.55e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 155 RRATYVSERADGVTDIWAAVPLKDGHVMSLHSGFTDRSADILHDLDQALVIGSIAVVLGGSALGVLIGGQLSRRLREAAA 234
Cdd:COG4191 11 LLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 235 AANQVANGEPDVRVRDAIGGVVRDETDDVARAVDAMADTLQQRIEAER-----RVTADIAHELRTPVTGLLTAAELL--- 306
Cdd:COG4191 91 EALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKlaalgELAAGIAHEINNPLAAILGNAELLrrr 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 307 --PPGRPTEL--VLDRAKA----MRTLVEDVLEVARLDGAS-ERAELQDIMLGHFVSRRVAAKDPAVTVRVVHESE---V 374
Cdd:COG4191 171 leDEPDPEELreALERILEgaerAAEIVRSLRAFSRRDEEErEPVDLNELIDEALELLRPRLKARGIEVELDLPPDlppV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 375 TTDPRRLERVLFNLLANAA---RHGRPP---IEVSVEGR--VIRVRDHGPGFPQHLIAegpsR-----FRTgsrDRAGRG 441
Cdd:COG4191 251 LGDPGQLEQVLLNLLINAIdamEEGEGGritISTRREGDyvVISVRDNGPGIPPEVLE----RifepfFTT---KPVGKG 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 739915594 442 HGLGLTIAAGQARVLGARLTFRNvrpagaapdEPAEGAVAVLWLPEH 488
Cdd:COG4191 324 TGLGLSISYGIVEKHGGRIEVES---------EPGGGTTFTITLPLA 361
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
75-448 |
9.91e-19 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 88.60 E-value: 9.91e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 75 LRWKLSAAIALVGALVAVALSLVVHNA--------------ARVSM----LDNARDLADDRV--------------LIAQ 122
Cdd:TIGR01386 4 LTLRLALLFAAVTALVFALSGFMLYSSlerhfeerdreelqGKLEQvrrfLRDPADLDEDIKrlqekiddllvghsDLAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 123 RNYELSGRQNFPNAKIDDPALPPELRRKTEAGRRATYVSERADGVTDIWAAVPLKDGHVMSLHSGFTDRSAD--ILHDLD 200
Cdd:TIGR01386 84 SILNPDGRLLFERAQGAALVPAVAANDALLELDQADAKMTHYRSILRSVAALPGGKGRKPVQITVALDINAHthLLDALR 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 201 QALVIGSIAVVLGGSALGVLIGGQLSRRLREAAAAANQVANGEPDVRVRDAiggVVRDETDDVARAVDAMADTLQQRIEA 280
Cdd:TIGR01386 164 KWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPS---RAPAELRELAQSFNAMLGRLEDAFQR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 281 ERRVTADIAHELRTPVTGLLTAAE--LLPPGRPTELV------LDRAKAMRTLVEDVLEVARLDGASERAELQDIMLGHF 352
Cdd:TIGR01386 241 LSQFSADLAHELRTPLTNLLGQTQvaLSQPRTGEEYRevlesnLEELERLSRMVSDMLFLARADNGQLALERVRLDLAAE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 353 VSRRVA-----AKDPAVTVRVVHESEVTTDPRRLERVLFNLLANAARHGRP--PIEVSVEGRV----IRVRDHGPGFPQH 421
Cdd:TIGR01386 321 LAKVAEyfeplAEERGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDggTITVRIERRSdevrVSVSNPGPGIPPE 400
|
410 420
....*....|....*....|....*....
gi 739915594 422 LIAEGPSRF--RTGSRDRAGRGHGLGLTI 448
Cdd:TIGR01386 401 HLSRLFDRFyrVDPARSNSGEGTGLGLAI 429
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
381-485 |
1.26e-18 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 81.11 E-value: 1.26e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 381 LERVLFNLLANAARHGRP--PIEVSV----EGRVIRVRDHGPGFPQHLIAEGPSRFRTGSRDRAGRGHGLGLTIAAGQAR 454
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPggTIEISLrqegDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80
|
90 100 110
....*....|....*....|....*....|.
gi 739915594 455 VLGARLTFRNvrpagaapdEPAEGAVAVLWL 485
Cdd:cd00075 81 AHGGRITVES---------EPGGGTTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
376-486 |
3.29e-18 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 80.00 E-value: 3.29e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 376 TDPRRLERVLFNLLANAARHGRPPIEVSVEGR------VIRVRDHGPGFPQHLIAEGPSRF-RTGSRDRAGRGHGLGLTI 448
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLErdgdhvEITVEDNGPGIPPEDLEKIFEPFfRTDKRSRKIGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|....*...
gi 739915594 449 AAGQARVLGARLTFRNvrpagaapdEPAEGAVAVLWLP 486
Cdd:smart00387 81 VKKLVELHGGEISVES---------EPGGGTTFTITLP 109
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
262-463 |
4.63e-18 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 86.58 E-value: 4.63e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 262 DVARAVDAMADTLQQRIEAERRVTADIAHELRTPVTGL---------LTAAEllppgrptELVLDR-AKAMRTLVEDVLE 331
Cdd:PRK10604 193 RLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLryrlemsdnLSAAE--------SQALNRdIGQLEALIEELLT 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 332 VARLDGASERAELQDIMLGHFVSRRVA---AKDPAVTVRVV---HESEVTTDPRRLERVLFNLLANAARH--GRPPIEVS 403
Cdd:PRK10604 265 YARLDRPQNELHLSEPDLPAWLSTHLAdiqAVTPEKTVRLDtphQGDYGALDMRLMERVLDNLLNNALRYahSRVRVSLL 344
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 739915594 404 VEGR--VIRVRDHGPGFPQhliAEGPSRFR-----TGSRDRAGRGHGLGLTIAAGQARVL------------GARLTFR 463
Cdd:PRK10604 345 LDGNqaCLIVEDDGPGIPP---EERERVFEpfvrlDPSRDRATGGCGLGLAIVHSIALAMggsvncdeselgGARFSFS 420
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
34-449 |
7.73e-18 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 86.38 E-value: 7.73e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 34 EPGGRFASRGPGETTGPTGLTGPARPTGLRRLLRGRSIRTGLRWKLSAAIALVGALVAVALSLVVHNAARVSMLDNARDL 113
Cdd:COG4251 26 LVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 114 ADDRVLIAQRNYELSGRQNFPNAKIDDPALPPELRRKTEAGRRATYVSERADGVTD--IWAAVPLKDGHVMSLHSGFTDR 191
Cdd:COG4251 106 LLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLllLALILALLLAALAELELLLLLL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 192 SADILHDLDQALVIGSIAVVLGGSALGVLIGGQLSRRLREAAAAANQVANGEPDVRVRDAIGGVVRDETDDVARAVDAMA 271
Cdd:COG4251 186 LVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELE 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 272 DTLQQRIEAERRVTAD-------IAHELRTPVTGLLTAAELL---PPGRPTE-------LVLDRAKAMRTLVEDVLEVAR 334
Cdd:COG4251 266 EELEERTAELERSNEEleqfayvASHDLREPLRKISGFSQLLeedYGDKLDEegreyleRIRDAAERMQALIDDLLAYSR 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 335 LDgaSERAELQDIMLGHFVSR-----RVAAKDPAVTVRVVHESEVTTDPRRLERVLFNLLANAARHGR----PPIEVSVE 405
Cdd:COG4251 346 VG--RQELEFEPVDLNELLEEvledlEPRIEERGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRpgepPRIEIGAE 423
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 739915594 406 ----GRVIRVRDHGPGF-PQHLiaegpSR----FRTGSRDRAGRGHGLGLTIA 449
Cdd:COG4251 424 reggEWVFSVRDNGIGIdPEYA-----EKifeiFQRLHSRDEYEGTGIGLAIV 471
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
376-487 |
2.69e-16 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 74.71 E-value: 2.69e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 376 TDPRRLERVLFNLLANAARHGRPP----IEVSVEGRV-IRVRDHGPGFPQHLIAEGPSRFRTGSRdRAGRGHGLGLTIAA 450
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAgeitVTLSEGGELtLTVEDNGIGIPPEDLPRIFEPFSTADK-RGGGGTGLGLSIVR 79
|
90 100 110
....*....|....*....|....*....|....*..
gi 739915594 451 GQARVLGARLTFRNvrpagaapdEPAEGAVAVLWLPE 487
Cdd:pfam02518 80 KLVELLGGTITVES---------EPGGGTTVTLTLPL 107
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
276-448 |
2.40e-15 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 77.25 E-value: 2.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 276 QRIEAERR-VTADIAHELRTPVTGL------LTAAELLPP---GRPTELVLDRAKAMRTLVEDVLEVARLDGASERAELQ 345
Cdd:TIGR02966 108 RRLEQMRRdFVANVSHELRTPLTVLrgyletLADGPDEDPeewNRALEIMLEQSQRMQSLVEDLLTLSRLESAASPLEDE 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 346 ----DIMLGHFVSRRVAA---KDPAVTVRVVHESEVTTDPRRLERVLFNLLANAARHGRPPIEVSV------EGRVIRVR 412
Cdd:TIGR02966 188 pvdmPALLDHLRDEAEALsqgKNHQITFEIDGGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVrwrrdgGGAEFSVT 267
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 739915594 413 DHGPGF-PQHL--IAEgpsRF----RTGSRDRAgrGHGLGLTI 448
Cdd:TIGR02966 268 DTGIGIaPEHLprLTE---RFyrvdKSRSRDTG--GTGLGLAI 305
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
267-469 |
8.86e-15 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 76.61 E-value: 8.86e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 267 VDAMaDTLQQRIEA----ERRVTADIAHELRTPVTGLLTAAELL------PPGRPTELV-----LDRAKamrTLVEDVLE 331
Cdd:PRK10337 220 VEAL-NQLFARTHAmmvrERRFTSDAAHELRSPLAALKVQTEVAqlsdddPQARKKALLqlhagIDRAT---RLVDQLLT 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 332 VARLDGASERAELQDIMLGHFVSRRVAAKDPA-----VTVRV---VHESEVTTDPRRLERVLFNLLANAARHGRP--PIE 401
Cdd:PRK10337 296 LSRLDSLDNLQDVAEIPLEDLLQSAVMDIYHTaqqagIDVRLtlnAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQgsVVD 375
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 739915594 402 VSVEGRVIRVRDHGPGF-PQHLIAEGPSRFRTGSRDRAGRghGLGLTIAAGQARVLGARLTFRNVRPAG 469
Cdd:PRK10337 376 VTLNARNFTVRDNGPGVtPEALARIGERFYRPPGQEATGS--GLGLSIVRRIAKLHGMNVSFGNAPEGG 442
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
274-486 |
3.76e-13 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 70.65 E-value: 3.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 274 LQQRIEAERRVTADIAHELRTPVTGLLTAAELL------PPGRP-TELVLDRAKAMRTLVEDVLEVARldgaSERAELQD 346
Cdd:COG3852 128 RAEKLAAVGELAAGLAHEIRNPLTGIRGAAQLLerelpdDELREyTQLIIEEADRLNNLVDRLLSFSR----PRPPEREP 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 347 IMLGHFVSR--RVAAKDPAVTVRVVHE-----SEVTTDPRRLERVLFNLLANAA---------------RHGRPPIEVSV 404
Cdd:COG3852 204 VNLHEVLERvlELLRAEAPKNIRIVRDydpslPEVLGDPDQLIQVLLNLVRNAAeampeggtitirtrvERQVTLGGLRP 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 405 EGRV-IRVRDHGPGFPQHLiaegpsrfrtgsRDRA--------GRGHGLGLTIAAGQARVLGARLTFRNvrpagaapdEP 475
Cdd:COG3852 284 RLYVrIEVIDNGPGIPEEI------------LDRIfepffttkEKGTGLGLAIVQKIVEQHGGTIEVES---------EP 342
|
250
....*....|.
gi 739915594 476 AEGAVAVLWLP 486
Cdd:COG3852 343 GKGTTFRIYLP 353
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
187-490 |
1.60e-12 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 70.06 E-value: 1.60e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 187 GFTDRSADILHD-LDQALVIgsiaVVLGGSALGVLIGGQLSRRLREAAAAANqvANGEPDVRVRDAIGGvvRDETDDVAR 265
Cdd:PRK15347 286 NLANEALKPALQqLPFALLI----LVLLTSVLFLLLRRYLAKPLWRFVDIIN--KTGPAALEPRLPENR--LDELGSIAK 357
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 266 AVDAMADTLQQ-------------------RIEAE---RRVT---ADIAHELRTPVTGLLTAAELLppgRPTELVLDRAK 320
Cdd:PRK15347 358 AYNQLLDTLNEqydtlenkvaertqalaeaKQRAEqanKRKSehlTTISHEIRTPLNGVLGALELL---QNTPLTAEQMD 434
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 321 AMRT----------LVEDVLEVAR------------------LDGA----SERAELQDIMLGHFVSRRVAAkdpavtvrv 368
Cdd:PRK15347 435 LADTarqctlsllaIINNLLDFSRiesgqmtlsleetallplLDQAmltiQGPAQSKSLTLRTFVGAHVPL--------- 505
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 369 vhesEVTTDPRRLERVLFNLLANAAR---HGRPPIEVSVEGR--VIRVRDHGPGFPqhlIAEGPSRFRTGSR-DRAGRGH 442
Cdd:PRK15347 506 ----YLHLDSLRLRQILVNLLGNAVKfteTGGIRLRVKRHEQqlCFTVEDTGCGID---IQQQQQIFTPFYQaDTHSQGT 578
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 739915594 443 GLGLTIAAGQARVLGARLTFRNvrpagaapdEPAEGAVAVLWLP--EHAP 490
Cdd:PRK15347 579 GLGLTIASSLAKMMGGELTLFS---------TPGVGSCFSLVLPlnEYAP 619
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
191-462 |
1.64e-12 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 69.47 E-value: 1.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 191 RSADILHDLDQ---ALVIGSIAVVLGGSAlGVLIGGQLSRRLREAAAAANQVANGEPDVRVRDAIGgvvrDETDDVARAV 267
Cdd:NF012163 152 RNTDINFDSQQkraSWLIVALALLLAALA-AFLLARGLLAPVKRLVEATHRLAAGDYTTRVTPTSN----DELGKLAQDF 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 268 DAMADTLQQRIEAERRVTADIAHELRTPVTGLLTAAELLPPG-RP--TELVLDRAKAMRTLVEDVLEVARLDGASERA-- 342
Cdd:NF012163 227 NQLASTLEKNEQMRRDFMADISHELRTPLAVLRAELEAIQDGiRKftPESLDSLQAEVGTLTKLVDDLHDLSMSDEGAla 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 343 ---------ELQDIMLGHFvSRRVAAKDPAVTVRVVHESEVTTDPRRLERVLFNLLANAARH----GRPPIEVSVEGR-- 407
Cdd:NF012163 307 yqkasvdlvPLLEVEGGAF-RERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYtdsgGSLHISASQRPKev 385
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 739915594 408 VIRVRDHGPGFPQHLIAEGPSRF-RT-GSRDRAGRGHGLGLTIAAGQARVLGARLTF 462
Cdd:NF012163 386 TLTVADSAPGVSDEQLARLFERFyRVeVSRNRASGGSGLGLAISLNIVQAHGGTLHA 442
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
191-448 |
5.66e-12 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 67.74 E-value: 5.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 191 RSADILHDLDQAL---VIGSIAVVLGGSALGVLIGGQLS--RRLREAAaaaNQVANGEPDVRVRDAiggvVRDETDDVAR 265
Cdd:PRK10549 152 RNTDINFDKQQRRtswLIVALSTLLAALATFLLARGLLApvKRLVEGT---HKLAAGDFTTRVTPT----SRDELGRLAQ 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 266 AVDAMADTLQQRIEAERRVTADIAHELRTPVTGLLTAAELLPPG--RPTELVLDRAKA----MRTLVEDVLEVARLD--- 336
Cdd:PRK10549 225 DFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGELEAIQDGvrKFTPESVASLQAevgtLTKLVDDLHQLSLSDega 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 337 -----GASERAELQDIMLGHFvSRRVAAKDPAVTVRVVHESEVTTDPRRLERVLFNLLANAARHGRPPIEVSVEGR---- 407
Cdd:PRK10549 305 layrkTPVDLVPLLEVAGGAF-RERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEqrdk 383
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 739915594 408 --VIRVRDHGPGFPQHLIAEGPSRF-RT-GSRDRAGRGHGLGLTI 448
Cdd:PRK10549 384 tlRLTFADSAPGVSDEQLQKLFERFyRTeGSRNRASGGSGLGLAI 428
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
258-487 |
1.12e-11 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 66.14 E-value: 1.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 258 DETDDVARAVDAMADTLQQRIEAERRVTADIAHELRTPVTGLLTAAELLPPGRPTEL--VLDRAKAMRTLVEDVLEVARL 335
Cdd:PRK10755 114 LEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLELLEKQHHIDVapLIARLDQMMHTVEQLLQLARA 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 336 -----DGASERAEL-QDIMLGHFVSRRVAAKDPAVTVRVVH---ESEVTTDPRRLERVLFNLLANAARHGrPP---IEVS 403
Cdd:PRK10755 194 gqsfsSGHYQTVKLlEDVILPSQDELSEMLEQRQQTLLLPEsaaDITVQGDATLLRLLLRNLVENAHRYS-PEgstITIK 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 404 VE----GRVIRVRDHGPGFPQHLIAEGPSRFRtgsR-DRAGRGHGLGLTIAAGQARVLGARLTFRNVRPAGaapdepaeG 478
Cdd:PRK10755 273 LSqedgGAVLAVEDEGPGIDESKCGELSKAFV---RmDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQERS--------G 341
|
....*....
gi 739915594 479 AVAVLWLPE 487
Cdd:PRK10755 342 TRAWVWLPK 350
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
272-446 |
1.90e-11 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 65.74 E-value: 1.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 272 DTLQQRIEAERRVTADIAHELRTPVTGLLTAAELLPPGRPTELV----------LDRAKA----MRTLVEDVLEVARLDG 337
Cdd:PRK09303 142 ETLLEQLKFKDRVLAMLAHDLRTPLTAASLALETLELGQIDEDTelkpalieqlQDQARRqleeIERLITDLLEVGRTRW 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 338 ASERAELQDIMLG------------HFVSRRVAAK-DPAVTVRVVHesevtTDPRRLERVLFNLLANAARHGRP--PIEV 402
Cdd:PRK09303 222 EALRFNPQKLDLGslcqevilelekRWLAKSLEIQtDIPSDLPSVY-----ADQERIRQVLLNLLDNAIKYTPEggTITL 296
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 739915594 403 SVEGRV-----IRVRDHGPGFP---QHLIAEGpsRFRTgSRDRAGRGHGLGL 446
Cdd:PRK09303 297 SMLHRTtqkvqVSICDTGPGIPeeeQERIFED--RVRL-PRDEGTEGYGIGL 345
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
285-448 |
1.90e-11 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 66.33 E-value: 1.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 285 TADIAHELRTPVTGLLTAAEL-LPPGR-PTELV------LDRAKAMRTLVEDVLEVARLDGASERAE-----LQDIMLGH 351
Cdd:PRK09835 266 SADIAHEIRTPITNLITQTEIaLSQSRsQKELEdvlysnLEELTRMAKMVSDMLFLAQADNNQLIPEkkmldLADEVGKV 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 352 FVSRRVAAKDPAVTVRVV-HESEVTTDPRRLERVLFNLLANAARHgRPP-----IEVSVEGRVIRVRDHGPGFP---QHL 422
Cdd:PRK09835 346 FDFFEAWAEERGVELRFVgDPCQVAGDPLMLRRAISNLLSNALRY-TPAgeaitVRCQEVDHQVQLVVENPGTPiapEHL 424
|
170 180
....*....|....*....|....*..
gi 739915594 423 IAEGPSRFRTG-SRDRAGRGHGLGLTI 448
Cdd:PRK09835 425 PRLFDRFYRVDpSRQRKGEGSGIGLAI 451
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
169-448 |
2.88e-11 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 65.32 E-value: 2.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 169 DIWAAVPLkdghvMSLHSGftDRSADILhdldQALVIGsiAVVLGGsalGVLIGGQLSRRLREAAAAANQVANGE--PDV 246
Cdd:PRK09467 137 NIWVRVPL-----TEIHQG--DFSPLFR----YTLAIG--LLSVAG---GWLFIRIQNRPLVALEHAALQVGKGEipPPL 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 247 RVRDAiggvvrDETDDVARAVDAMADTLQQrIEAERR-VTADIAHELRTPVTGLLTAAELLPPGRP--TELVLDRAKAMR 323
Cdd:PRK09467 201 REYGA------SEVRSVTRAFNQMAAGIKQ-LEDDRTlLMAGVSHDLRTPLTRIRLATEMMSEEDGylAESINKDIEECN 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 324 TLVEDVLEVARLD--GASERAELQDIMlghfvsRRVAAkdpAVTVR-VVHESEVTTDPRRLE-------RVLFNLLANAA 393
Cdd:PRK09467 274 AIIEQFIDYLRTGqeMPMEMADLNALL------GEVIA---AESGYeREIETALQPGPIEVPmnpiaikRALANLVVNAA 344
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 739915594 394 RHGRPPIEVS--VEGR--VIRVRDHGPGFPQHLIAEGPSRFRTGSRDRAGRGHGLGLTI 448
Cdd:PRK09467 345 RYGNGWIKVSsgTEGKraWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSSGTGLGLAI 403
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
209-448 |
9.29e-11 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 63.48 E-value: 9.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 209 AVVLGGSALGVLIGGQLSRR----LREAAAAANQVANGEPDVRVRDAiggvvRDETDDVARAVD---AMADTLQQRIEAE 281
Cdd:NF012226 64 TVILCGSVISLIIGMKLAQRfivpINFLADAAKKISQGDLSARAEDS-----QIHSAEISELMHnfnDMAQKLESSVKNA 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 282 RRVTADIAHELRTPVT-----------GLLTAAELLppgrpTELVLDRAKAMRTLVEDV--LEVA-----RLDgaSERAE 343
Cdd:NF012226 139 QVWNAAIAHELRTPITilqgrlqgildGVFEPDPAL-----FKSLLNQVEGLSHLVEDLrtLSLVenqqlRLN--YESVD 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 344 LQDIM---LGHFVSRRVAAKdpAVTVRVVHESEVTTDPRRLERVLFNLLANAARH---GRPPIEVSV--EGRVIRVRDHG 415
Cdd:NF012226 212 LKDSIekvLKMFEDRLEQAQ--LTIVLNLTATPVFCDRRRIEQVLIALIDNAIRYanaGKLKISSSViqDDWILQIEDEG 289
|
250 260 270
....*....|....*....|....*....|....*.
gi 739915594 416 PGFPQHLIAE--GPSrFR-TGSRDRAGRGHGLGLTI 448
Cdd:NF012226 290 PGIAEEYQQDlfNPF-FRlEQSRNKEFGGTGLGLAV 324
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
280-336 |
1.65e-10 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 56.84 E-value: 1.65e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 739915594 280 AERRVTADIAHELRTPVTGLLTAAELLPPGRPTE-------LVLDRAKAMRTLVEDVLEVARLD 336
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEeqreyleTILRSAERLLRLINDLLDLSRIE 64
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
212-486 |
1.66e-10 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 62.94 E-value: 1.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 212 LGGSALGVLIGGQLSRRLREAAAAANQVANGEP------DVRVRDAIGGVV---RDETDdvaraVDAMADTL---QQRIE 279
Cdd:COG3290 117 LGLDAIGRPIDEVLAEVLETGERDEEILLNGRVlvvnrvPIRDDGRVVGAVatfRDRTE-----LERLEEELegvKELAE 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 280 AERRVTADIAHELRTpVTGLLTaaellppgrptelvLDRAKAMRTLVEDVLEVARLDGASERAELQDIMLGHFVSRRVA- 358
Cdd:COG3290 192 ALRAQRHDFRNHLHT-ISGLLQ--------------LGEYDEALEYIDEISEELQELIDSLLSRIGNPVLAALLLGKAAr 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 359 AKDPAVTVRVVHESEVTTDPRR---LERVLFNLLANAARH------GRPPIEVSVEGR----VIRVRDHGPGFPQHLIAE 425
Cdd:COG3290 257 ARERGIDLTIDIDSDLPDLPLSdtdLVTILGNLLDNAIEAveklpeEERRVELSIRDDgdelVIEVEDSGPGIPEELLEK 336
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 739915594 426 gpsRFRTGSRDRAGRGHGLGLTIAAGQARVLGARLTFRnvrpagaapDEPAEGAVAVLWLP 486
Cdd:COG3290 337 ---IFERGFSTKLGEGRGLGLALVKQIVEKYGGTIEVE---------SEEGEGTVFTVRLP 385
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
280-336 |
8.88e-10 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 54.88 E-value: 8.88e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 739915594 280 AERRVTADIAHELRTPVTGLLTAAELL-------PPGRPTELVLDRAKAMRTLVEDVLEVARLD 336
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLldtelseEQREYLETILREAERLLRLINDLLDLSRIE 64
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-486 |
2.76e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 54.38 E-value: 2.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 381 LERVLFNLLANAARHGRPPIEVSVEGR----VIRVRDHGPGFPQHLIAEGPSRFRTGSRDRAGRGHGLGLTIAAGQARVL 456
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVEVSSDGEgnrtRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRISDAH 80
|
90 100 110
....*....|....*....|....*....|
gi 739915594 457 GARLTFRNvRPAGaapdepaeGAVAVLWLP 486
Cdd:cd16950 81 GGSLTLAN-RAGG--------GLCARIELP 101
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
275-471 |
4.13e-09 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 59.28 E-value: 4.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 275 QQRIEAERR-----VTADIAHELRTPVTGLLTAAELlppgrpteLVLD----------RAKAMRT-------LVEDVLEV 332
Cdd:PRK10490 653 QARLASEREqlrnaLLAALSHDLRTPLTVLFGQAEI--------LTLDlasegspharQASEIRQqvlnttrLVNNLLDM 724
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 333 ARL--DGASERAE---LQDI------MLGHFVSRRVAAKDPAVTVRVVHesevtTDPRRLERVLFNLLANAARHGRPPIE 401
Cdd:PRK10490 725 ARIqsGGFNLRKEwltLEEVvgsalqMLEPGLSGHPINLSLPEPLTLIH-----VDGPLFERVLINLLENAVKYAGAQAE 799
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 739915594 402 VSVEGRV------IRVRDHGPGFP---QHLIAEgpsRFRTGSRDRAGRGHGLGLTIAAGQARVLGARLTFRNvRPAGAA 471
Cdd:PRK10490 800 IGIDAHVegerlqLDVWDNGPGIPpgqEQLIFD---KFARGNKESAIPGVGLGLAICRAIVEVHGGTIWAEN-RPEGGA 874
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
278-334 |
4.69e-09 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 52.60 E-value: 4.69e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 739915594 278 IEAERRVTADIAHELRTPVTGLLTAAELLPPGRPT--------ELVLDRAKAMRTLVEDVLEVAR 334
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDdeeqreylERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-471 |
7.37e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 53.23 E-value: 7.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 381 LERVLFNLLANA--ARHGRPPIEVSVEGR------VIRVRDHGPGFPQHLIAEGPSRFRTgSRDrAGRGHGLGLTIAAGQ 452
Cdd:cd16976 1 IQQVLMNLLQNAldAMGKVENPRIRIAARrlggrlVLVVRDNGPGIAEEHLSRVFDPFFT-TKP-VGKGTGLGLSISYGI 78
|
90
....*....|....*....
gi 739915594 453 ARVLGARLTFRNVRPAGAA 471
Cdd:cd16976 79 VEEHGGRLSVANEEGAGAR 97
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
202-464 |
1.11e-08 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 57.83 E-value: 1.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 202 ALVIGSIAVVLGGSALGVLIGGQLSRRLREAAaaaNQVANG-EPDVRVRDAIGGV-VRDETDDVARAVDAMADTLQQRIE 279
Cdd:TIGR03785 407 KLFNVILAIMSIGTLALFGFASWISWRIRRLS---DDAEAAiDSQGRISGAIPASrSRDEIGDLSRSFAQMVARLRQYTH 483
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 280 AERRVTADIAHELRTPVTGLLTAAELLPPGRPTEL---VLDRAKA----MRTLVEDVLEVARLDGASERAELQDIMLGHF 352
Cdd:TIGR03785 484 YLENMSSRLSHELRTPVAVVRSSLENLELQALEQEkqkYLERAREgterLSMILNNMSEATRLEQAIQSAEVEDFDLSEV 563
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 353 VSRRVAAKDPAVTVR----VVHESEVTTD--PRRLERVLFNLLANAAR--HGRPPIEVSVE----GRVIRVRDHGPGFPQ 420
Cdd:TIGR03785 564 LSGCMQGYQMTYPPQrfelNIPETPLVMRgsPELIAQMLDKLVDNAREfsPEDGLIEVGLSqnksHALLTVSNEGPPLPE 643
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 739915594 421 HLIAEGPSRFRTGSRDRAGRGH--GLGLTIAAGQARVLGARLTFRN 464
Cdd:TIGR03785 644 DMGEQLFDSMVSVRDQGAQDQPhlGLGLYIVRLIADFHQGRIQAEN 689
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
275-461 |
1.32e-08 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 57.61 E-value: 1.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 275 QQRIEAER------RVTADIAHELRTPVTGLLTAAELLP--PGRPT-----ELVLDRAKAMRTLVEDVLEVARLDGASER 341
Cdd:PRK11466 432 QARAEAEKasqaksAFLAAMSHEIRTPLYGILGTAQLLAdnPALNAqrddlRAITDSGESLLTILNDILDYSAIEAGGKN 511
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 342 AELQDIMLG---------HFVSRRVAAKdpavTVRVVHE------SEVTTDPRRLERVLFNLLANAARHG-RPPIEVSV- 404
Cdd:PRK11466 512 VSVSDEPFEprpllestlQLMSGRVKGR----PIRLATDiaddlpTALMGDPRRIRQVITNLLSNALRFTdEGSIVLRSr 587
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 405 ---EGRVIRVRDHGPGFPQHLIAEGPSRFRTGSRDRAGRghGLGLTIAAGQARVLGARLT 461
Cdd:PRK11466 588 tdgEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRGGT--GLGLTISSRLAQAMGGELS 645
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-486 |
1.86e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 52.33 E-value: 1.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 381 LERVLFNLLANAARHGRPPIEV--SVEGR--VIRVRDHGPGFPQhliAEGPSRF----RTGS-RDRAGRGHGLGLTIAAG 451
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLdiSQDGDqwTITITDDGPGVPE---DQLEQIFlpfyRVDSaRDRESGGTGLGLAIAER 77
|
90 100 110
....*....|....*....|....*....|....*
gi 739915594 452 QARVLGARLTfrnvrpagaAPDEPAEGAVAVLWLP 486
Cdd:cd16949 78 AIEQHGGKIK---------ASNRKPGGLRVRIWLP 103
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
270-454 |
4.57e-08 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 55.32 E-value: 4.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 270 MADTLQQRIEAERRVTADIAHELRTPVTGLLTAAELL--PPGRPTELVLDRAKAMR--TLVEDVLEVAR----------- 334
Cdd:PRK09470 232 MVTALERMMTSQQRLLSDISHELRTPLTRLQLATALLrrRQGESKELERIETEAQRldSMINDLLVLSRnqqknhleret 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 335 ----------LDGASERAELQDIMLghfvsrrvaakdpavtvrvvhesEVTTDPRR---------LERVLFNLLANAARH 395
Cdd:PRK09470 312 fkanslwsevLEDAKFEAEQMGKSL-----------------------TVSAPPGPwpingnpnaLASALENIVRNALRY 368
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 739915594 396 GRPPIEVSV----EGRVIRVRDHGPGFPQhliAEGPSRFR-----TGSRDRAGRGHGLGLTIAAGQAR 454
Cdd:PRK09470 369 SHTKIEVAFsvdkDGLTITVDDDGPGVPE---EEREQIFRpfyrvDEARDRESGGTGLGLAIVENAIQ 433
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
377-470 |
5.12e-08 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 50.95 E-value: 5.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 377 DPRRLERVLFNLLANAARH----GRppIEVSVE-----GRVIRVRDHGPGFPQHLIAEGPSRFRTGSRD--RAGRGHGLG 445
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFtpdgGR--IRCILEkfrlnRFLLTVSDSGPGIPPNLREEIFERFRQGDGSstRAHGGTGLG 78
|
90 100
....*....|....*....|....*
gi 739915594 446 LTIAAGQARVLGARLTFRNVRPAGA 470
Cdd:cd16925 79 LSIVKEFVELHGGTVTVSDAPGGGA 103
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
377-485 |
1.04e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 50.15 E-value: 1.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 377 DPRRLERVLFNLLANAaRHGRPP-------IEVSVEGRVIRVRDHGPGFPQHLIAEGPSRFRTGSRDRAG-RGHGLGLTI 448
Cdd:cd16945 1 DPFLLRQAINNLLDNA-IDFSPEgglialqLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGqKSTGLGLAF 79
|
90 100 110
....*....|....*....|....*....|....*..
gi 739915594 449 AAGQARVLGARLTFRNVRpagaapdepaEGAVAVLWL 485
Cdd:cd16945 80 VQEVAQLHGGRITLRNRP----------DGVLAFLTL 106
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
263-448 |
1.25e-07 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 53.86 E-value: 1.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 263 VARAVDAMadtlqQRIEAERR-VTADIAHELRTPVTGLLTAAELLP----PGRPTELVL----DRAKAMRTLVEDVLEVA 333
Cdd:PRK11006 190 VARDVTQM-----HQLEGARRnFFANVSHELRTPLTVLQGYLEMMQdqplEGALREKALhtmrEQTQRMEGLVKQLLTLS 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 334 RLDgASERAELQDI----MLGHFVSRRVAA---KDPAVTVRVVHESEVTTDPRRLERVLFNLLANAARHgRPP---IEVS 403
Cdd:PRK11006 265 KIE-AAPTIDLNEKvdvpMMLRVLEREAQTlsqGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNH-TPEgthITVR 342
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 739915594 404 ----VEGRVIRVRDHGPGF-PQHL--IAEgpsRF-RTG-SRDRAGRGHGLGLTI 448
Cdd:PRK11006 343 wqrvPQGAEFSVEDNGPGIaPEHIprLTE---RFyRVDkARSRQTGGSGLGLAI 393
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
275-486 |
4.90e-07 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 52.28 E-value: 4.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 275 QQRIEAERRVTADIAHELRTPVTGLLTAAELL---PPGRPTE----LVLDRAKAMRTLVEDVLEVARldgaSERAELQDI 347
Cdd:PRK11360 384 QERLAALGELVAGVAHEIRNPLTAIRGYVQIWrqqTSDPPSQeylsVVLREVDRLNKVIDQLLEFSR----PRESQWQPV 459
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 348 MLGHFVSR-----RVAAKDPAVTVRVVHESEVTT---DPRRLERVLFNLLANA--ARHGRPPIEVSVE----GRV-IRVR 412
Cdd:PRK11360 460 SLNALVEEvlqlfQTAGVQARVDFETELDNELPPiwaDPELLKQVLLNILINAvqAISARGKIRIRTWqysdGQVaVSIE 539
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 739915594 413 DHGPGFPQHLIAEGPSRFRTgsrDRAgRGHGLGLTIAAGQARVLGARLTFRNvrpagaapdEPAEGAVAVLWLP 486
Cdd:PRK11360 540 DNGCGIDPELLKKIFDPFFT---TKA-KGTGLGLALSQRIINAHGGDIEVES---------EPGVGTTFTLYLP 600
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
275-449 |
8.12e-07 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 51.24 E-value: 8.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 275 QQriEAERRVTADIAHELRTPVTGLLTAAELLPPGRP-------TELVLDRAKAMRTLVEdvlevaRLDGASE--RAELQ 345
Cdd:PRK11073 126 QQ--VAARDLVRGLAHEIKNPLGGLRGAAQLLSKALPdpalteyTKVIIEQADRLRNLVD------RLLGPQRpgTHVTE 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 346 DImlgHFVSRRVAA-----KDPAVT-VRVVHES--EVTTDPRRLERVLFNLLANAA-----RHG------RPPIEVSVEG 406
Cdd:PRK11073 198 SI---HKVAERVVQlvsleLPDNVRlIRDYDPSlpELAHDPDQIEQVLLNIVRNALqalgpEGGtitlrtRTAFQLTLHG 274
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 739915594 407 ---RV---IRVRDHGPGFPQHLiaeGPSRFRTGSRDRAGrGHGLGLTIA 449
Cdd:PRK11073 275 eryRLaarIDIEDNGPGIPPHL---QDTLFYPMVSGREG-GTGLGLSIA 319
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
377-462 |
1.32e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 47.07 E-value: 1.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 377 DPRRLERVLFNLLANAARH----GRPPIEVSVEGRVIR--VRDHGPGFPQHLIAEGPSRF-RT-GSRDRAGRGHGLGLTI 448
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYtdtgGKLRIRAAQTPQEVRldVEDSAPGVSDDQLARLFERFyRVeSSRNRASGGSGLGLAI 80
|
90
....*....|....
gi 739915594 449 AAGQARVLGARLTF 462
Cdd:cd16946 81 CHNIALAHGGTISA 94
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
273-449 |
1.77e-06 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 50.52 E-value: 1.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 273 TLQQRIEAERR--VtADIAHELRTPVT-----------GLLTAAELLPpgRPTELVLDRAKAMRTLVEDVLEVARLDGAS 339
Cdd:NF033092 363 TEQEKIEQERRefV-ANVSHELRTPLTtmrsylealadGAWKDPELAP--RFLGVTQNETERMIRLVNDLLQLSRMDSKD 439
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 340 ERAELQDI---MLGHFVSRR--VAAKDPAVTVRVVHESE---VTTDPRRLERVLFNLLANAARH----GRppIEVSV--- 404
Cdd:NF033092 440 YKLNKEWVnfnEFFNYIIDRfeMILKNKNITFKREFPKRdlwVEIDTDKITQVLDNIISNAIKYspegGT--ITFRLlet 517
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 739915594 405 EGRV-IRVRDHGPGFPQHLIAEGPSRF-RTG-SRDRAGRGHGLGLTIA 449
Cdd:NF033092 518 HNRIiISISDQGLGIPKKDLDKIFDRFyRVDkARSRKMGGTGLGLAIA 565
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-459 |
2.60e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 45.88 E-value: 2.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 381 LERVLFNLLANAARHGRPPIEVSVEGR----VIRVRDHGPGFPQHL---IAEGPSRFRTgSRDRAGRGHGLGLTIAAGQA 453
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVSggrlTLIVEDDGPGIPAAArerVFEPFVRLDP-SRDRATGGFGLGLAIVHRVA 79
|
....*.
gi 739915594 454 RVLGAR 459
Cdd:cd16939 80 LWHGGH 85
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
60-304 |
6.58e-06 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 48.86 E-value: 6.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 60 TGLRRLLRGRSIRTGLRWKLSAAIALVGALVAVALSLVVHNAARVSMLDNARDLADDRVLIAQRNYELSGRQNFPNAKID 139
Cdd:COG0840 41 TALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALALAALALLAALAALLALLELLL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 140 DPALPPELRRKTEAGRRATYVSERADGVTDIWAAVPLKDGHVMSLHSGFTDRSADILHDLDQALVIGSIAVVLGGSALGV 219
Cdd:COG0840 121 AALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILAL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 220 LIGGQLSRRLREAAAAANQVANGepDVRVRDAIGGvvRDETDDVARAVDAMADTLQQRIEAERRVT---ADIAHELRTPV 296
Cdd:COG0840 201 LLSRSITRPLRELLEVLERIAEG--DLTVRIDVDS--KDEIGQLADAFNRMIENLRELVGQVRESAeqvASASEELAASA 276
|
....*...
gi 739915594 297 TGLLTAAE 304
Cdd:COG0840 277 EELAAGAE 284
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
259-448 |
1.22e-05 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 48.19 E-value: 1.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 259 ETDDVARAVDAMADTLQQRIEAERRVTADIAHELRTPVTGLLTAAELLP-PGRPTE-------LVLDRAKAMRTLVEDVL 330
Cdd:PRK09959 690 ETRDLIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSgSGLSKEqrveaisLAYATGQSLLGLIGEIL 769
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 331 EVARLDGASERAELQDIMLGHFVSRR-------VAAKDPAVTVRVVHESE--VTTDPRRLERVLFNLLANAAR---HGRP 398
Cdd:PRK09959 770 DVDKIESGNYQLQPQWVDIPTLVQNTchsfgaiAASKSIALSCSSTFPDHylVKIDPQAFKQVLSNLLSNALKfttEGAV 849
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 739915594 399 PIEVSV-----EGRVIR--VRDHGPGFPQHLIAEGPSRFRTGSRDRAGRGHGLGLTI 448
Cdd:PRK09959 850 KITTSLghiddNHAVIKmtIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMI 906
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
370-469 |
1.70e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 43.93 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 370 HESEVTTDPRRLERVLFNLLANAARH----GRppIEVSVEGR---VIRVRDHGPGFPQHLIAEGPSRF-RTGSRDraGRG 441
Cdd:cd16940 3 ADIQVQGDALLLFLLLRNLVDNAVRYspqgSR--VEIKLSADdgaVIRVEDNGPGIDEEELEALFERFyRSDGQN--YGG 78
|
90 100
....*....|....*....|....*...
gi 739915594 442 HGLGLTIAAGQARVLGARLTFRNVRPAG 469
Cdd:cd16940 79 SGLGLSIVKRIVELHGGQIFLGNAQGGG 106
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
387-486 |
2.09e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 43.43 E-value: 2.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 387 NLLANA----ARHGRPPIEVSVEGR------VIRVRDHGPGFPQHLIAEgpsRFRTGSRDRAGRGHGLGLTIAAGQARVL 456
Cdd:cd16915 7 NLIDNAldalAATGAPNKQVEVFLRdegddlVIEVRDTGPGIAPELRDK---VFERGVSTKGQGERGIGLALVRQSVERL 83
|
90 100 110
....*....|....*....|....*....|
gi 739915594 457 GARLTFRNvrpagaapdEPAEGAVAVLWLP 486
Cdd:cd16915 84 GGSITVES---------EPGGGTTFSIRIP 104
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
202-448 |
2.15e-05 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 46.99 E-value: 2.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 202 ALVIGSIAVVLggsALGVL-IGGQLSRRLREAAAAANQVANGEPDVRVrdAIGGvvRDETDDVARAVDAMADT------- 273
Cdd:COG4192 330 AIALLSLLLAV---LINYFyVRRRLVKRLNALSDAMAAIAAGDLDVPI--PVDG--NDEIGRIARLLRVFRDQaiektqe 402
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 274 LQQRIEAERRVTAD-----------------------IAHELRTPVTGL---LTAAELLPPGRPTELVLDRAKAMRTLVE 327
Cdd:COG4192 403 LETEIEERKRIEKNlrqtqdeliqaakmavvgqtmtsLAHELNQPLNAMsmyLFSAKKALEQENYAQLPTSLDKIEGLIE 482
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 328 DV-LEVARLDGASERAElQDImlgHFVSRRVAAKDPAVTVRVVHESE-----------VTTDPRRLERVLFNLLANA--A 393
Cdd:COG4192 483 RMdKIIKSLRQFSRKSD-TPL---QPVDLRQVIEQAWELVESRAKPQqitlhipddlmVQGDQVLLEQVLVNLLVNAldA 558
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 739915594 394 RHGRPPIEVSV----EGRVIRVRDHGPGFPqhlIAEGPSRFRTGSRDragRGHGLGLTI 448
Cdd:COG4192 559 VATQPQISVDLlsnaENLRVAISDNGNGWP---LVDKLFTPFTTTKE---VGLGLGLSI 611
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-467 |
5.52e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 42.89 E-value: 5.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 381 LERVLFNLLANAARHGRppievsvEGRV-------------IRVRDHGPGFPQHLIAEGPSRFRT--GSRDRAGRGHGLG 445
Cdd:cd16947 21 LQRILKNLISNAIKYGS-------DGKFlgmtlredekhvyIDIWDKGKGISETEKDHVFERLYTleDSRNSAKQGNGLG 93
|
90 100
....*....|....*....|..
gi 739915594 446 LTIAAGQARVLGARLTFrNVRP 467
Cdd:cd16947 94 LTITKRLAESMGGSIYV-NSKP 114
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
268-489 |
6.64e-05 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 45.55 E-value: 6.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 268 DAMADtlQQRIEAERRVTADIAHELRTPVT---GLLTA-AELLPPG----------------------------RPTELV 315
Cdd:PRK10364 226 DEMKR--KEKLVALGHLAAGVAHEIRNPLSsikGLAKYfAERAPAGgeahqlaqvmakeadrlnrvvsellelvKPTHLA 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 316 LdRAKAMRTLVEDVLEVARLDGASERAELQdimlghfvsRRVAAKDPAVTVrvvhesevttDPRRLERVLFNLLANA--- 392
Cdd:PRK10364 304 L-QAVDLNDLINHSLQLVSQDANSREIQLR---------FTANDTLPEIQA----------DPDRLTQVLLNLYLNAiqa 363
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 393 -ARHGRPPIEVSVEGR--VIRVRDHGPGF-PQHLIAEGPSRFRTgsrdrAGRGHGLGLTIAAGQARVLGARLTfrnvrpa 468
Cdd:PRK10364 364 iGQHGVISVTASESGAgvKISVTDSGKGIaADQLEAIFTPYFTT-----KAEGTGLGLAVVHNIVEQHGGTIQ------- 431
|
250 260
....*....|....*....|.
gi 739915594 469 gaAPDEPAEGAVAVLWLPEHA 489
Cdd:PRK10364 432 --VASQEGKGATFTLWLPVNI 450
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
388-446 |
7.23e-05 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 42.59 E-value: 7.23e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 739915594 388 LLANAARHGRPP-------IEVSVEGR--VIRVRDHGPGFPQHLIAEGPSrfrtgsrDRAGRGHGLGL 446
Cdd:COG2172 42 AVTNAVRHAYGGdpdgpveVELELDPDglEIEVRDEGPGFDPEDLPDPYS-------TLAEGGRGLFL 102
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
377-470 |
9.03e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 41.68 E-value: 9.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 377 DPRRLERVLFNLLANAARHGRPPIEVSV----EGRVIR--VRDHGPGFPQHLIAEGPSRFRTGSRDRAGRGH-GLGLTIA 449
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSIsiydEEEYLYfeIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHyGMGLYIA 80
|
90 100
....*....|....*....|.
gi 739915594 450 AGQARVLGARLTFRNVRPAGA 470
Cdd:cd16975 81 KNLVEKHGGSLIIENSQKGGA 101
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
271-486 |
1.50e-04 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 44.67 E-value: 1.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 271 ADTLQQRIEAERRVTA------DIAHELRTPVTGLLTAAEL----LPPGRPT----ELVLDRAKAMRTLVEDVLEVAR-L 335
Cdd:PRK13837 434 RDALERRLEHARRLEAvgtlasGIAHNFNNILGAILGYAEMalnkLARHSRAaryiDEIISAGARARLIIDQILAFGRkG 513
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 336 DGASERAELQDiMLGHFVSRRVAAKDPAVTVRVVHESE---VTTDPRRLERVLFNLLANAARHGRPP--IEVSVE----- 405
Cdd:PRK13837 514 ERNTKPFDLSE-LVTEIAPLLRVSLPPGVELDFDQDQEpavVEGNPAELQQVLMNLCSNAAQAMDGAgrVDISLSraklr 592
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 406 ------------GR--VIRVRDHGPGFPQHLIAEGPSRFRTgsrDRAGrGHGLGLTIAAGQARVLGARLtfrNVRPAgaa 471
Cdd:PRK13837 593 apkvlshgvlppGRyvLLRVSDTGAGIDEAVLPHIFEPFFT---TRAG-GTGLGLATVHGIVSAHAGYI---DVQST--- 662
|
250
....*....|....*
gi 739915594 472 pdePAEGAVAVLWLP 486
Cdd:PRK13837 663 ---VGRGTRFDVYLP 674
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
81-483 |
1.82e-04 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 44.33 E-value: 1.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 81 AAIALVGALVAVALSLVVHNAARVSMLDNARDLADDRVLIAQRNYELSGRQNFPNAKIDDPALPPELRRKTEAGRRATYV 160
Cdd:COG2770 92 LALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAG 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 161 SERADGVTDIWAAVPLKDGHVMSLHSGFTDRSADILHDLDQALVIGSIAVVLGGSALGVLIGGQLSRRLREAAAAANQVA 240
Cdd:COG2770 172 ELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIA 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 241 NGEPDVRVRDAiggvVRDETDDVARAVDAMADTLQQRIEAERRVTADIAHELRTPVTGLLTAAELLPPGRPTELVLDRAK 320
Cdd:COG2770 252 AGDLDVRIPVS----RKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAA 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 321 AMRTLVEDVLEVARLDGASERAELQDIMLGHFVSRRVAAKDPAVTVRVVHESEVTTDPRRLERVLFNLLANAARHGRPPI 400
Cdd:COG2770 328 LLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLEL 407
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 401 EVSVEGRVIRVRDHGPGFPQHLIAEGPSRFRTGSRDRAGRGHGLGLTIAAGQARVLGARLTFRNVRPAGAAPDEPAEGAV 480
Cdd:COG2770 408 ALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGAL 487
|
...
gi 739915594 481 AVL 483
Cdd:COG2770 488 ELL 490
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
283-448 |
3.12e-04 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 43.18 E-value: 3.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 283 RVTADIAHELRTPVT---GLLTaaeLLPPGRPT-----ELVLDRAKAMRTLVEDVLEVARLDGASERAELQDIMLGHFVS 354
Cdd:COG5805 289 QLAAGIAHEIRNPLTsikGFLQ---LLQPGIEDkeeyfDIMLSELDRIESIISEFLALAKPQAVNKEKENINELIQDVVT 365
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 355 RRVA-AKDPAVTVRVVHESEVTT---DPRRLERVLFNLLANA----ARHGRPPIEVSVEGR--VIRVRDHGPGFPQHLIA 424
Cdd:COG5805 366 LLETeAILHNIQIRLELLDEDPFiycDENQIKQVFINLIKNAieamPNGGTITIHTEEEDNsvIIRVIDEGIGIPEERLK 445
|
170 180
....*....|....*....|....*
gi 739915594 425 E-GPSRFRTGSrdragRGHGLGLTI 448
Cdd:COG5805 446 KlGEPFFTTKE-----KGTGLGLMV 465
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
388-448 |
5.78e-04 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 39.17 E-value: 5.78e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 388 LLANAARHGRP-----PIEVSVEGR----VIRVRDHGPGFPqhliaegpsRFRTGSRDRAGRGHGLGLTI 448
Cdd:cd16936 8 AVTNAVRHAYRhdgpgPVRLELDLDpdrlRVEVTDSGPGFD---------PLRPADPDAGLREGGRGLAL 68
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
251-469 |
7.14e-04 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 41.53 E-value: 7.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 251 AIGGVVRDETDDVARAVDAMADTLQQRIEAERRvtaDIAHELRTPVTGLLTA-------AELLPPGRPtELVLDRAKAMR 323
Cdd:COG4585 23 ALVLLRARRAERAAELERELAARAEEAREEERR---RIARELHDGVGQSLSAiklqleaARRLLDADP-EAAREELEEIR 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 324 TLVEDVLEVAR----------LDGASERAELQDIMlghfvsrRVAAKDPAVTVRVVHESEVTTDPRRLERVLF----NLL 389
Cdd:COG4585 99 ELAREALAELRrlvrglrppaLDDLGLAAALEELA-------ERLLRAAGIRVELDVDGDPDRLPPEVELALYrivqEAL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 390 ANAARHGRP-PIEVSVEGR----VIRVRDHGPGFPqhliaegpsrfrtgsrDRAGRGHGLGLTIAAGQARVLGARLTFRN 464
Cdd:COG4585 172 TNALKHAGAtRVTVTLEVDdgelTLTVRDDGVGFD----------------PEAAPGGGLGLRGMRERAEALGGTLTIGS 235
|
....*
gi 739915594 465 VRPAG 469
Cdd:COG4585 236 APGGG 240
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
377-471 |
1.00e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 38.67 E-value: 1.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 377 DPRRLERVLFNLLANAAR--HGRP--PIEVSV------EGR-VIRVRDHGPGFPQHLIAEGPSRFRTgsrDRAgRGHGLG 445
Cdd:cd16944 1 DTTQISQVLTNILKNAAEaiEGRPsdVGEVRIrveadqDGRiVLIVCDNGKGFPREMRHRATEPYVT---TRP-KGTGLG 76
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90 100
....*....|....*....|....*.
gi 739915594 446 LTIAAGQARVLGARLTFRNvRPAGAA 471
Cdd:cd16944 77 LAIVKKIMEEHGGRISLSN-REAGGA 101
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| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-449 |
1.92e-03 |
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Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 37.75 E-value: 1.92e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 739915594 381 LERVLFNLLANAARHGRPP----IEVSVEGRV--IRVRDHGPGFPQHLIAEGPSRFRTGSRDRAGRGHGLGLTIA 449
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENtriyITSFLTDDVvnIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIA 75
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| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
388-441 |
2.62e-03 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 38.04 E-value: 2.62e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 739915594 388 LLANAARHGRP-----PIEVSVEGR----VIRVRDHGPGFPQHLIAEGPSRFRTGSRDRAGRG 441
Cdd:pfam13581 39 ACTNAVEHAYRegpegPVEVRLTSDggglVVTVADSGPPFDPLTLPPPDLEEPDEDRKEGGRG 101
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| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
377-470 |
2.83e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 38.00 E-value: 2.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 739915594 377 DPRRLERVLFNLLANAARHGRPPIEVSV----EGRVIRVRDHGPGFPQHLIAEgpsRFRTGSR-DRAGRGHGLGLTIAAG 451
Cdd:cd16954 34 ERNDLMELLGNLLDNACKWCLEFVEVTArqtdGGLHLIVDDDGPGVPESQRSK---IFQRGQRlDEQRPGQGLGLAIAKE 110
|
90
....*....|....*....
gi 739915594 452 QARVLGARLTFRNVRPAGA 470
Cdd:cd16954 111 IVEQYGGELSLSDSPLGGA 129
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| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
224-279 |
4.78e-03 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 35.30 E-value: 4.78e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 739915594 224 QLSRRLREAAAAANQVANGEPDVRVRDAiggvVRDETDDVARAVDAMADTLQQRIE 279
Cdd:smart00304 2 RLLRPLRRLAEAAQRIADGDLTVRLPVD----GRDEIGELARAFNEMADRLEETIA 53
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