Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA ...
138-581
1.20e-179
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. These enzymes are usually homodimers. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. The substrate specificity of this reaction is further determined by additional domains. Intererestingly, this domain is also found is asparagine synthase A (AsnA), in the accessory subunit of mitochondrial polymerase gamma and in the bacterial ATP phosphoribosyltransferase regulatory subunit HisZ.
The actual alignment was detected with superfamily member PRK02983:
Pssm-ID: 444800 [Multi-domain] Cd Length: 1094 Bit Score: 537.63 E-value: 1.20e-179
Phosphatidylglycerol lysyltransferase, C-terminal; This domain can be found in the C-terminal ...
253-559
1.35e-102
Phosphatidylglycerol lysyltransferase, C-terminal; This domain can be found in the C-terminal region of phosphatidylglycerol lysyltransferase mprF, which catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG). This domain can also be found in lysylphosphatidylglycerol biosynthesis bifunctional protein LysX, which is the two-domain lysyl-transferase (mprF)-lysyl-tRNA synthetase (lysU) protein is responsible for LPG production.
Pssm-ID: 430930 [Multi-domain] Cd Length: 297 Bit Score: 312.66 E-value: 1.35e-102
bifunctional lysylphosphatidylglycerol flippase/synthetase MprF; The C-terminal region of MprF ...
140-568
3.28e-40
bifunctional lysylphosphatidylglycerol flippase/synthetase MprF; The C-terminal region of MprF tranfers lysine from a charged tRNA onto phosphatidylglycerol to make lysylphosphatidylglycerol (EC 2.3.2.3). The N-terminal region of MprF acts as a flippase. MprF helps confer resistance to antimicrobial cationic peptides.
Pssm-ID: 468043 [Multi-domain] Cd Length: 839 Bit Score: 156.90 E-value: 3.28e-40
Phosphatidylglycerol lysyltransferase, C-terminal; This domain can be found in the C-terminal ...
253-559
1.35e-102
Phosphatidylglycerol lysyltransferase, C-terminal; This domain can be found in the C-terminal region of phosphatidylglycerol lysyltransferase mprF, which catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG). This domain can also be found in lysylphosphatidylglycerol biosynthesis bifunctional protein LysX, which is the two-domain lysyl-transferase (mprF)-lysyl-tRNA synthetase (lysU) protein is responsible for LPG production.
Pssm-ID: 430930 [Multi-domain] Cd Length: 297 Bit Score: 312.66 E-value: 1.35e-102
bifunctional lysylphosphatidylglycerol flippase/synthetase MprF; The C-terminal region of MprF ...
140-568
3.28e-40
bifunctional lysylphosphatidylglycerol flippase/synthetase MprF; The C-terminal region of MprF tranfers lysine from a charged tRNA onto phosphatidylglycerol to make lysylphosphatidylglycerol (EC 2.3.2.3). The N-terminal region of MprF acts as a flippase. MprF helps confer resistance to antimicrobial cationic peptides.
Pssm-ID: 468043 [Multi-domain] Cd Length: 839 Bit Score: 156.90 E-value: 3.28e-40
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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