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Conserved domains on  [gi|740438155|ref|WP_038270174|]
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MULTISPECIES: LysR family transcriptional regulator [Xenorhabdus]

Protein Classification

LysR family transcriptional regulator( domain architecture ID 10444001)

LysR family HTH-containing transcriptional regulator similar to Streptomyces cacaoi BlaA, which functions as a positive regulator for the expression of the gene (blaB) for beta-lactamase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_1 pfam00126
Bacterial regulatory helix-turn-helix protein, lysR family;
5-62 2.06e-15

Bacterial regulatory helix-turn-helix protein, lysR family;


:

Pssm-ID: 459683 [Multi-domain]  Cd Length: 60  Bit Score: 68.95  E-value: 2.06e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 740438155    5 RKLEAFMAVVEMGSLSKAARVMNRTTPPVAKSIKDFEATLGKRLFKREKFGMILTKDG 62
Cdd:pfam00126   2 RQLRLFVAVAETGSFTAAAERLGLSQPAVSRQIKRLEEELGVPLFERTTRGVRLTEAG 59
 
Name Accession Description Interval E-value
HTH_1 pfam00126
Bacterial regulatory helix-turn-helix protein, lysR family;
5-62 2.06e-15

Bacterial regulatory helix-turn-helix protein, lysR family;


Pssm-ID: 459683 [Multi-domain]  Cd Length: 60  Bit Score: 68.95  E-value: 2.06e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 740438155    5 RKLEAFMAVVEMGSLSKAARVMNRTTPPVAKSIKDFEATLGKRLFKREKFGMILTKDG 62
Cdd:pfam00126   2 RQLRLFVAVAETGSFTAAAERLGLSQPAVSRQIKRLEEELGVPLFERTTRGVRLTEAG 59
LysR COG0583
DNA-binding transcriptional regulator, LysR family [Transcription];
5-72 2.27e-15

DNA-binding transcriptional regulator, LysR family [Transcription];


Pssm-ID: 440348 [Multi-domain]  Cd Length: 256  Bit Score: 73.75  E-value: 2.27e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 740438155   5 RKLEAFMAVVEMGSLSKAARVMNRTTPPVAKSIKDFEATLGKRLFKREKFGMILTKDGVELYNDLKEL 72
Cdd:COG0583    4 RQLRAFVAVAEEGSFTAAAERLGVSQPAVSRQIRRLEEELGVPLFERTGRGLRLTEAGERLLERARRI 71
LysR_Sec_metab NF040786
selenium metabolism-associated LysR family transcriptional regulator; LysR family ...
 5-77 5.43e-11

selenium metabolism-associated LysR family transcriptional regulator; LysR family transcriptional regulators regularly appear encoded adjacent to selenecysteine incorporation proteins such as SelB. This model represents one especially well-conserved subgroup of such transcription factors from species such as Merdimonas faecis, Sellimonas intestinalis, Syntrophotalea acetylenica, and Hydrogenivirga caldilitoris. Seed alignment members were selected by proximity to selB, but not all family members are expected to have similar genomic locations.


Pssm-ID: 468737 [Multi-domain]  Cd Length: 298  Bit Score: 61.86  E-value: 5.43e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 740438155   5 RKLEAFMAVVEMGSLSKAARVMNRTTPPVAKSIKDFEATLGKRLFKREKFGMILTKDGVELYNDLKE-LYLKEK 77
Cdd:NF040786   4 KQLEAFVNVAEYKSFSKAAKKLFLTQPTISAHISSLEKELGVRLFVRNTKEVSLTEDGKLLYEYAKEmLDLWEK 77
PRK09791 PRK09791
LysR family transcriptional regulator;
6-94 5.88e-10

LysR family transcriptional regulator;


Pssm-ID: 182077 [Multi-domain]  Cd Length: 302  Bit Score: 59.01  E-value: 5.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740438155   6 KLEAFMAVVEMGSLSKAARVMNRTTPPVAKSIKDFEATLGKRLFKREKFGMILTKDGVELYND----LKELYLKEKEITK 81
Cdd:PRK09791   9 QIRAFVEVARQGSIRGASRMLNMSQPALTKSIQELEEGLAAQLFFRRSKGVTLTDAGESFYQHasliLEELRAAQEDIRQ 88

                         90
                 ....*....|...
gi 740438155  82 KHfsGTICNSVNI 94
Cdd:PRK09791  89 RQ--GQLAGQINI 99
 
Name Accession Description Interval E-value
HTH_1 pfam00126
Bacterial regulatory helix-turn-helix protein, lysR family;
5-62 2.06e-15

Bacterial regulatory helix-turn-helix protein, lysR family;


Pssm-ID: 459683 [Multi-domain]  Cd Length: 60  Bit Score: 68.95  E-value: 2.06e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 740438155    5 RKLEAFMAVVEMGSLSKAARVMNRTTPPVAKSIKDFEATLGKRLFKREKFGMILTKDG 62
Cdd:pfam00126   2 RQLRLFVAVAETGSFTAAAERLGLSQPAVSRQIKRLEEELGVPLFERTTRGVRLTEAG 59
LysR COG0583
DNA-binding transcriptional regulator, LysR family [Transcription];
5-72 2.27e-15

DNA-binding transcriptional regulator, LysR family [Transcription];


Pssm-ID: 440348 [Multi-domain]  Cd Length: 256  Bit Score: 73.75  E-value: 2.27e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 740438155   5 RKLEAFMAVVEMGSLSKAARVMNRTTPPVAKSIKDFEATLGKRLFKREKFGMILTKDGVELYNDLKEL 72
Cdd:COG0583    4 RQLRAFVAVAEEGSFTAAAERLGVSQPAVSRQIRRLEEELGVPLFERTGRGLRLTEAGERLLERARRI 71
LysR_Sec_metab NF040786
selenium metabolism-associated LysR family transcriptional regulator; LysR family ...
 5-77 5.43e-11

selenium metabolism-associated LysR family transcriptional regulator; LysR family transcriptional regulators regularly appear encoded adjacent to selenecysteine incorporation proteins such as SelB. This model represents one especially well-conserved subgroup of such transcription factors from species such as Merdimonas faecis, Sellimonas intestinalis, Syntrophotalea acetylenica, and Hydrogenivirga caldilitoris. Seed alignment members were selected by proximity to selB, but not all family members are expected to have similar genomic locations.


Pssm-ID: 468737 [Multi-domain]  Cd Length: 298  Bit Score: 61.86  E-value: 5.43e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 740438155   5 RKLEAFMAVVEMGSLSKAARVMNRTTPPVAKSIKDFEATLGKRLFKREKFGMILTKDGVELYNDLKE-LYLKEK 77
Cdd:NF040786   4 KQLEAFVNVAEYKSFSKAAKKLFLTQPTISAHISSLEKELGVRLFVRNTKEVSLTEDGKLLYEYAKEmLDLWEK 77
PRK09791 PRK09791
LysR family transcriptional regulator;
6-94 5.88e-10

LysR family transcriptional regulator;


Pssm-ID: 182077 [Multi-domain]  Cd Length: 302  Bit Score: 59.01  E-value: 5.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740438155   6 KLEAFMAVVEMGSLSKAARVMNRTTPPVAKSIKDFEATLGKRLFKREKFGMILTKDGVELYND----LKELYLKEKEITK 81
Cdd:PRK09791   9 QIRAFVEVARQGSIRGASRMLNMSQPALTKSIQELEEGLAAQLFFRRSKGVTLTDAGESFYQHasliLEELRAAQEDIRQ 88

                         90
                 ....*....|...
gi 740438155  82 KHfsGTICNSVNI 94
Cdd:PRK09791  89 RQ--GQLAGQINI 99
PRK13348 PRK13348
HTH-type transcriptional regulator ArgP;
1-78 2.62e-07

HTH-type transcriptional regulator ArgP;


Pssm-ID: 237357 [Multi-domain]  Cd Length: 294  Bit Score: 50.74  E-value: 2.62e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 740438155   1 MFFSRKLEAFMAVVEMGSLSKAARVMNRTTPPVAKSIKDFEATLGKRLFKREKfGMILTKDGVELYNDLKELYLKEKE 78
Cdd:PRK13348   1 MLDYKQLEALAAVVETGSFERAARRLHVTPSAVSQRIKALEESLGQPLLVRGR-PCRPTPAGQRLLRHLRQVALLEAD 77
PRK10094 PRK10094
HTH-type transcriptional activator AllS;
1-65 1.29e-05

HTH-type transcriptional activator AllS;


Pssm-ID: 182237 [Multi-domain]  Cd Length: 308  Bit Score: 45.95  E-value: 1.29e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 740438155   1 MFFSRKLEAFMAVVEMGSLSKAARVMNRTTPPVAKSIKDFEATLGKRLFKREKFGMILTKDGVEL 65
Cdd:PRK10094   1 MFDPETLRTFIAVAETGSFSKAAERLCKTTATISYRIKLLEENTGVALFFRTTRSVTLTAAGEHL 65
PRK15243 PRK15243
virulence genes transcriptional activator SpvR;
2-74 1.46e-05

virulence genes transcriptional activator SpvR;


Pssm-ID: 185155 [Multi-domain]  Cd Length: 297  Bit Score: 45.82  E-value: 1.46e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 740438155   2 FFSRKLEAFMAVVEMGSLSKAARVMNRTTPPVAKSIKDFEATLGKRLFKREKFGMILTKDGVELYNDLKELYL 74
Cdd:PRK15243   4 LINKKLKIFITLMETGSFSIATSVLYITRTPLSRVISDLERELKQRLFIRKNGTLIPTEFAQTIYRKVKSHYI 76
PRK10341 PRK10341
transcriptional regulator TdcA;
4-67 5.54e-05

transcriptional regulator TdcA;


Pssm-ID: 182391 [Multi-domain]  Cd Length: 312  Bit Score: 44.08  E-value: 5.54e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 740438155   4 SRKLEAFMAVVEMGSLSKAARVMNRTTPPVAKSIKDFEATLGKRLFKREKFGMILTKDGVELYN 67
Cdd:PRK10341   9 TQHLVVFQEVIRSGSIGSAAKELGLTQPAVSKIINDIEDYFGVELIVRKNTGVTLTPAGQVLLS 72
PRK09986 PRK09986
LysR family transcriptional regulator;
5-72 6.52e-05

LysR family transcriptional regulator;


Pssm-ID: 182183 [Multi-domain]  Cd Length: 294  Bit Score: 43.56  E-value: 6.52e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 740438155   5 RKLEAFMAVVEMGSLSKAARVMNRTTPPVAKSIKDFEATLGKRLFKREKFGMILTKDGVELYNDLKEL 72
Cdd:PRK09986  10 KLLRYFLAVAEELHFGRAAARLNISQPPLSIHIKELEDQLGTPLFIRHSRSVVLTHAGKILMEESRRL 77
PRK11013 PRK11013
DNA-binding transcriptional regulator LysR; Provisional
 5-73 6.74e-05

DNA-binding transcriptional regulator LysR; Provisional


Pssm-ID: 236819 [Multi-domain]  Cd Length: 309  Bit Score: 43.44  E-value: 6.74e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 740438155   5 RKLEAFMAVVEMGSLSKAARVMNRTTPPVAKSIKDFEATLGKRLFKREKFGMILTKDGVELYNDLKELY 73
Cdd:PRK11013   7 RHIEIFHAVMTAGSLTEAARLLHTSQPTVSRELARFEKVIGLKLFERVRGRLHPTVQGLRLFEEVQRSY 75
PRK09906 PRK09906
DNA-binding transcriptional regulator HcaR; Provisional
 5-62 2.18e-04

DNA-binding transcriptional regulator HcaR; Provisional


Pssm-ID: 182137 [Multi-domain]  Cd Length: 296  Bit Score: 42.06  E-value: 2.18e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 740438155   5 RKLEAFMAVVEMGSLSKAARVMNRTTPPVAKSIKDFEATLGKRLFKREKFGMILTKDG 62
Cdd:PRK09906   4 RHLRYFVAVAEELNFTKAAEKLHTAQPSLSQQIKDLENCVGVPLLVRDKRKVALTAAG 61
PRK10837 PRK10837
putative DNA-binding transcriptional regulator; Provisional
 5-51 1.76e-03

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 182768 [Multi-domain]  Cd Length: 290  Bit Score: 39.29  E-value: 1.76e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 740438155   5 RKLEAFMAVVEMGSLSKAARVMNRTTPPVAKSIKDFEATLGKRLFKR 51
Cdd:PRK10837   6 RQLEVFAEVLKSGSTTQASVMLALSQSAVSAALTDLEGQLGVQLFDR 52
PRK15092 PRK15092
DNA-binding transcriptional repressor LrhA; Provisional
 7-65 2.68e-03

DNA-binding transcriptional repressor LrhA; Provisional


Pssm-ID: 237907 [Multi-domain]  Cd Length: 310  Bit Score: 38.86  E-value: 2.68e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 740438155   7 LEAFMAVVEMGSLSKAARVMNRTTPPVAKSIKDFEATLGKRLFKREKFGMILTKDGVEL 65
Cdd:PRK15092  16 LRTFVAVADLNTFAAAAAAVCRTQSAVSQQMQRLEQLVGKELFARHGRNKLLTEHGIQL 74
PRK10086 PRK10086
DNA-binding transcriptional regulator DsdC;
6-70 3.33e-03

DNA-binding transcriptional regulator DsdC;


Pssm-ID: 182231 [Multi-domain]  Cd Length: 311  Bit Score: 38.44  E-value: 3.33e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 740438155   6 KLEAFMAVVEMGSLSKAARVMNRTTPPVAKSIKDFEATLGKRLFKREKFGMILTKDGVELYNDLK 70
Cdd:PRK10086  18 KLHTFEVAARHQSFALAADELSLTPSAVSHRINQLEEELGIKLFVRSHRKVELTEEGKRVFWALK 82
PRK11233 PRK11233
nitrogen assimilation transcriptional regulator; Provisional
 5-66 3.66e-03

nitrogen assimilation transcriptional regulator; Provisional


Pssm-ID: 183045 [Multi-domain]  Cd Length: 305  Bit Score: 38.12  E-value: 3.66e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 740438155   5 RKLEAFMAVVEMGSLSKAARVMNRTTPPVAKSIKDFEATLGKRLFKREKFGMILTKDGVELY 66
Cdd:PRK11233   4 RRLKYFVKIVDIGSLTQAAEVLHIAQPALSQQVATLEGELNQQLLIRTKRGVTPTEAGKILY 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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