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Conserved domains on  [gi|740813717|ref|WP_038599000|]
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MurR/RpiR family transcriptional regulator [Lactococcus lactis]

Protein Classification

MurR/RpiR family transcriptional regulator( domain architecture ID 11448252)

MurR/RpiR family transcriptional regulator similar to Escherichia coli MurR, which represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid

CATH:  1.10.10.10
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  15808743|8576032
SCOP:  4000148

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-244 1.55e-42

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


:

Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 145.84  E-value: 1.55e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717   1 MSIFGKL--DFTSLTPTEKAIYNYLQDHIKEIPSSSIRQISAGSYAGTASVMRLIHKMNYKSFNDFKNFVKQTQKDNEPS 78
Cdd:COG1737    5 MSLLERIraRYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEGLSS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717  79 SDFFNSLSIDIYPSNLLQK--------------------LEALTEMILHSENILFFGVGASGATATLATRYLANLGVPgV 138
Cdd:COG1737   85 YERLRRLSPDDSLEDILAKvleaeianleetlelldeeaLERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKN-V 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717 139 FSLQDASWPIAKQLQNV-ADTLVIILSVSGETSEVLEAMAGMRKNaDTKIAVITANPSSEAALLSDLFISYQINEwHVNF 217
Cdd:COG1737  164 VLLDGDGHLQAESAALLgPGDVVIAISFSGYTRETLEAARLAKER-GAKVIAITDSPLSPLAKLADVVLYVPSEE-PTLR 241

                        250       260
                 ....*....|....*....|....*..
gi 740813717 218 SDDMTSQIPAMFISEKLAKAVYKRLKE 244
Cdd:COG1737  242 SSAFSSRVAQLALIDALAAAVAQRDGD 268
 
Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-244 1.55e-42

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 145.84  E-value: 1.55e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717   1 MSIFGKL--DFTSLTPTEKAIYNYLQDHIKEIPSSSIRQISAGSYAGTASVMRLIHKMNYKSFNDFKNFVKQTQKDNEPS 78
Cdd:COG1737    5 MSLLERIraRYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEGLSS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717  79 SDFFNSLSIDIYPSNLLQK--------------------LEALTEMILHSENILFFGVGASGATATLATRYLANLGVPgV 138
Cdd:COG1737   85 YERLRRLSPDDSLEDILAKvleaeianleetlelldeeaLERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKN-V 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717 139 FSLQDASWPIAKQLQNV-ADTLVIILSVSGETSEVLEAMAGMRKNaDTKIAVITANPSSEAALLSDLFISYQINEwHVNF 217
Cdd:COG1737  164 VLLDGDGHLQAESAALLgPGDVVIAISFSGYTRETLEAARLAKER-GAKVIAITDSPLSPLAKLADVVLYVPSEE-PTLR 241

                        250       260
                 ....*....|....*....|....*..
gi 740813717 218 SDDMTSQIPAMFISEKLAKAVYKRLKE 244
Cdd:COG1737  242 SSAFSSRVAQLALIDALAAAVAQRDGD 268
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 96-237 5.11e-23

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 90.75  E-value: 5.11e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717  96 QKLEALTEMILHSENILFFGVGASGATATLATRYLANLGVPgVFSLQDASWPIAKQLQNVADTLVIILSVSGETSEVLEa 175
Cdd:cd05013    1 EALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKP-VVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVE- 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 740813717 176 MAGMRKNADTKIAVITANPSSEAALLSDLFISYQINEwHVNFSDDMTSQIPAMFISEKLAKA 237
Cdd:cd05013   79 AAEIAKERGAKVIAITDSANSPLAKLADIVLLVSSEE-GDFRSSAFSSRIAQLALIDALFLA 139
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 104-206 2.06e-08

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 51.53  E-value: 2.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717  104 MILHSENILFFGVGASGATATLATRYLANLGVPgVFSLQDASWPIAKQLQNV-ADTLVIILSVSGETSEVLEAMAGMRKN 182
Cdd:pfam01380   1 LLAKAKRIFVIGRGTSYAIALELALKFEEIGYK-VVEVELASELRHGVLALVdEDDLVIAISYSGETKDLLAAAELAKAR 79

                          90       100
                  ....*....|....*....|....
gi 740813717  183 aDTKIAVITANPSSEAALLSDLFI 206
Cdd:pfam01380  80 -GAKIIAITDSPGSPLAREADHVL 102
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
11-200 1.41e-06

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 48.76  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717  11 SLTPTEKAIYNYLQDHIKEIPSSSIRQISAGSYAGTASVMRLIHKMNYKSFNDFK----------NFVKQTQ-KDNEPSS 79
Cdd:PRK14101 353 ALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKlklatgltgtIPMSHSQvHLGDTAT 432

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717  80 DFF-----NSLSIDIYPSNLL--QKLEALTEMILHSENILFFGVGASGATATLATRYLANLGVPgVFSLQDAswpiakQL 152
Cdd:PRK14101 433 DFGakvldNTVSAILQLREHLnfEHVEQAIDILNNARRIEFYGLGNSNIVAQDAHYKFFRFGIP-TIAYGDL------YM 505

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 740813717 153 QNVA------DTLVIILSVSGETSEVLEA-MAGMRknADTKIAVITANPSSEAAL 200
Cdd:PRK14101 506 QAASaallgkGDVIVAVSKSGRAPELLRVlDVAMQ--AGAKVIAITSSNTPLAKR 558
 
Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-244 1.55e-42

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 145.84  E-value: 1.55e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717   1 MSIFGKL--DFTSLTPTEKAIYNYLQDHIKEIPSSSIRQISAGSYAGTASVMRLIHKMNYKSFNDFKNFVKQTQKDNEPS 78
Cdd:COG1737    5 MSLLERIraRYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEGLSS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717  79 SDFFNSLSIDIYPSNLLQK--------------------LEALTEMILHSENILFFGVGASGATATLATRYLANLGVPgV 138
Cdd:COG1737   85 YERLRRLSPDDSLEDILAKvleaeianleetlelldeeaLERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKN-V 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717 139 FSLQDASWPIAKQLQNV-ADTLVIILSVSGETSEVLEAMAGMRKNaDTKIAVITANPSSEAALLSDLFISYQINEwHVNF 217
Cdd:COG1737  164 VLLDGDGHLQAESAALLgPGDVVIAISFSGYTRETLEAARLAKER-GAKVIAITDSPLSPLAKLADVVLYVPSEE-PTLR 241

                        250       260
                 ....*....|....*....|....*..
gi 740813717 218 SDDMTSQIPAMFISEKLAKAVYKRLKE 244
Cdd:COG1737  242 SSAFSSRVAQLALIDALAAAVAQRDGD 268
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 96-237 5.11e-23

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 90.75  E-value: 5.11e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717  96 QKLEALTEMILHSENILFFGVGASGATATLATRYLANLGVPgVFSLQDASWPIAKQLQNVADTLVIILSVSGETSEVLEa 175
Cdd:cd05013    1 EALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKP-VVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVE- 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 740813717 176 MAGMRKNADTKIAVITANPSSEAALLSDLFISYQINEwHVNFSDDMTSQIPAMFISEKLAKA 237
Cdd:cd05013   79 AAEIAKERGAKVIAITDSANSPLAKLADIVLLVSSEE-GDFRSSAFSSRIAQLALIDALFLA 139
AgaS COG2222
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ...
 87-206 9.08e-09

Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441824 [Multi-domain]  Cd Length: 336  Bit Score: 54.90  E-value: 9.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717  87 IDIYPSNLLQKLEALTEmiLHSENILFFGVGASGATATLATRYL-ANLGVPgVFSLQDASWPIAKQLQNVADTLVIILSV 165
Cdd:COG2222   15 LAALAAAIAALLARLRA--KPPRRVVLVGAGSSDHAAQAAAYLLeRLLGIP-VAALAPSELVVYPAYLKLEGTLVVAISR 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 740813717 166 SGETSEVLEAMAGMRKnADTKIAVITANPSSEAALLSDLFI 206
Cdd:COG2222   92 SGNSPEVVAALELAKA-RGARTLAITNNPDSPLAEAADRVL 131
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 104-206 2.06e-08

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 51.53  E-value: 2.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717  104 MILHSENILFFGVGASGATATLATRYLANLGVPgVFSLQDASWPIAKQLQNV-ADTLVIILSVSGETSEVLEAMAGMRKN 182
Cdd:pfam01380   1 LLAKAKRIFVIGRGTSYAIALELALKFEEIGYK-VVEVELASELRHGVLALVdEDDLVIAISYSGETKDLLAAAELAKAR 79

                          90       100
                  ....*....|....*....|....
gi 740813717  183 aDTKIAVITANPSSEAALLSDLFI 206
Cdd:pfam01380  80 -GAKIIAITDSPGSPLAREADHVL 102
SIS_PHI cd05005
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ...
 96-204 2.21e-08

Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.


Pssm-ID: 240138 [Multi-domain]  Cd Length: 179  Bit Score: 52.19  E-value: 2.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717  96 QKLEALTEMILHSENILFFGVGASGATA-TLATRyLANLGVPgVFSLQDASWP-IAKqlqnvaDTLVIILSVSGETSEVL 173
Cdd:cd05005   21 EELDKLISAILNAKRIFVYGAGRSGLVAkAFAMR-LMHLGLN-VYVVGETTTPaIGP------GDLLIAISGSGETSSVV 92

                         90       100       110
                 ....*....|....*....|....*....|.
gi 740813717 174 EAmAGMRKNADTKIAVITANPSSEAALLSDL 204
Cdd:cd05005   93 NA-AEKAKKAGAKVVLITSNPDSPLAKLADV 122
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
11-200 1.41e-06

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 48.76  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717  11 SLTPTEKAIYNYLQDHIKEIPSSSIRQISAGSYAGTASVMRLIHKMNYKSFNDFK----------NFVKQTQ-KDNEPSS 79
Cdd:PRK14101 353 ALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKlklatgltgtIPMSHSQvHLGDTAT 432

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717  80 DFF-----NSLSIDIYPSNLL--QKLEALTEMILHSENILFFGVGASGATATLATRYLANLGVPgVFSLQDAswpiakQL 152
Cdd:PRK14101 433 DFGakvldNTVSAILQLREHLnfEHVEQAIDILNNARRIEFYGLGNSNIVAQDAHYKFFRFGIP-TIAYGDL------YM 505

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 740813717 153 QNVA------DTLVIILSVSGETSEVLEA-MAGMRknADTKIAVITANPSSEAAL 200
Cdd:PRK14101 506 QAASaallgkGDVIVAVSKSGRAPELLRVlDVAMQ--AGAKVIAITSSNTPLAKR 558
PRK11337 PRK11337
MurR/RpiR family transcriptional regulator;
11-206 5.39e-06

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183089 [Multi-domain]  Cd Length: 292  Bit Score: 46.29  E-value: 5.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717  11 SLTPTEKAIYNYLQDHIKEIPSSSIRQISAGSYAGTASVMRLIHKMNYKSFNDFKNfvKQTQKDNEPSSDFFNSLSIDIY 90
Cdd:PRK11337  25 GLTPLESRVVEWLLKPGDLSEATALKDIAEALAVSEAMIVKVAKKLGFSGFRNLRS--ALEDYFSQSEQVLHSELSFDDA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717  91 PSNLLQK-----LEALTE---------------MILHSENILFFGVGASGATATLATRYLANLGVPGvfSLQDASWPIAK 150
Cdd:PRK11337 103 PQDVVNKvfntsLQAIEEtqsildvdefhraarFFYQARQRDLYGAGGSAAIARDVQHKFLRIGVRC--QAYDDAHIMLM 180

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 740813717 151 QLQNVADT-LVIILSVSGETSEVLEAMAGMRKNAdTKIAVITANPSSEAALLSDLFI 206
Cdd:PRK11337 181 SAALLQEGdVVLVVSHSGRTSDVIEAVELAKKNG-AKIICITNSYHSPIAKLADYVI 236
SIS_PGI_PMI_1 cd05017
The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the ...
 110-193 9.16e-06

The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to fructose 6-phosphate, and mannose 6-phosphate to fructose 6-phosphate, respectively at an equal rate. This protein contains two SIS domains. This alignment is based on the first SIS domain.


Pssm-ID: 240148 [Multi-domain]  Cd Length: 119  Bit Score: 43.79  E-value: 9.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717 110 NILFFGVGASGATATLATRYLA-NLGVPgVFSLQDASWPIAKQlqnvADTLVIILSVSGETSEVLEAMAGMRKnADTKIA 188
Cdd:cd05017    1 NIVILGMGGSGIGGDLLESLLLdEAKIP-VYVVKDYTLPAFVD----RKTLVIAVSYSGNTEETLSAVEQAKE-RGAKIV 74


                 ....*
gi 740813717 189 VITAN 193
Cdd:cd05017   75 AITSG 79
PRK08674 PRK08674
bifunctional phosphoglucose/phosphomannose isomerase; Validated
 61-192 1.30e-05

bifunctional phosphoglucose/phosphomannose isomerase; Validated


Pssm-ID: 181536 [Multi-domain]  Cd Length: 337  Bit Score: 45.36  E-value: 1.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717  61 FNDFKNFVKQTQKDNEPSSDFFNSLSIDIYpsnllqklealtemilhsENILFFGVGASGATATLATRYLA-NLGVPgVF 139
Cdd:PRK08674   5 LEEYLNWPEQFEEALEIAISLDLEEDLEKI------------------DNIVISGMGGSGIGGDLLRILLFdELKVP-VF 65

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 740813717 140 SLQDASWPIAKQlqnvADTLVIILSVSGETSEVLEAM-AGMRKNAdtKIAVITA 192
Cdd:PRK08674  66 VNRDYTLPAFVD----EKTLVIAVSYSGNTEETLSAVeQALKRGA--KIIAITS 113
SIS_Kpsf cd05014
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ...
 159-206 2.30e-05

KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-phosphate to arabinose 5-phosphate. This is the second step in the CMP-Kdo biosynthesis pathway.


Pssm-ID: 240145 [Multi-domain]  Cd Length: 128  Bit Score: 42.91  E-value: 2.30e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 740813717 159 LVIILSVSGETSEVLEAMAgMRKNADTKIAVITANPSSEAALLSDLFI 206
Cdd:cd05014   50 VVIAISNSGETDELLNLLP-HLKRRGAPIIAITGNPNSTLAKLSDVVL 96
GutQ COG0794
D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall ...
 156-206 1.32e-04

D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440557 [Multi-domain]  Cd Length: 317  Bit Score: 42.27  E-value: 1.32e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 740813717 156 ADTLVIILSVSGETSEVLeAMAGMRKNADTKIAVITANPSSEAALLSDLFI 206
Cdd:COG0794   91 PGDVVIAISNSGETEELL-ALLPLLKRLGVPLIAITGNPDSTLARAADVVL 140
SIS_GlmS_GlmD_1 cd05008
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and ...
 110-206 4.36e-04

SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal glutaminase domain and two C-terminal SIS domains and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. The end product of the pathway is N-acetylglucosamine, which plays multiple roles in eukaryotic cells including being a building block of bacterial and fungal cell walls. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate (PGI-like activity). Glucosamine-6-phosphate deaminase (GlmD) contains two SIS domains and catalyzes the deamination and isomerization of glucosamine-6-phosphate into fructose-6-phosphate with the release of ammonia; in presence of high ammonia concentration, GlmD can catalyze the reverse reaction.


Pssm-ID: 240141 [Multi-domain]  Cd Length: 126  Bit Score: 39.02  E-value: 4.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740813717 110 NILFFGVGASgATATLATRYLAN--LGVPgvFSLQDASWPIAKQLQNVADTLVIILSVSGETSEVLEAMAGMRKNADTKI 187
Cdd:cd05008    1 RILIVGCGTS-YHAALVAKYLLErlAGIP--VEVEAASEFRYRRPLLDEDTLVIAISQSGETADTLAALRLAKEKGAKTV 77

                         90
                 ....*....|....*....
gi 740813717 188 AvITANPSSEAALLSDLFI 206
Cdd:cd05008   78 A-ITNVVGSTLAREADYVL 95
SIS_1 cd05710
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar ...
 157-208 2.70e-03

A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240214 [Multi-domain]  Cd Length: 120  Bit Score: 36.79  E-value: 2.70e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 740813717 157 DTLVIILSVSGETSEVLEAMAGMRKNADTKIAvITANPSSEAALLSDLFISY 208
Cdd:cd05710   48 KSVVILASHSGNTKETVAAAKFAKEKGATVIG-LTDDEDSPLAKLADYVIVY 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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