cobalt-precorrin-5B (C(1))-methyltransferase; precorrin-6A/cobalt-precorrin-6A reductase family protein( domain architecture ID 11132968)
cobalt-precorrin-5B (C(1))-methyltransferase catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A| precorrin-6A/cobalt-precorrin-6A reductase catalyzes the reduction of the macrocycle of precorrin-6A or cobalt-precorrin-6A to precorrin-6B or cobalt-precorrin-6B, respectively; involved in cobalamin biosynthesis; may be partial
Cobalamin biosynthesis protein CbiD (cobalt-precorrin-5B C-methyltransferase) [Coenzyme ...
273-593
2.93e-141
Cobalamin biosynthesis protein CbiD (cobalt-precorrin-5B C-methyltransferase) [Coenzyme transport and metabolism]; Cobalamin biosynthesis protein CbiD (cobalt-precorrin-5B C-methyltransferase) is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
:
Pssm-ID: 441507 [Multi-domain] Cd Length: 368 Bit Score: 414.12 E-value: 2.93e-141
Cobalamin biosynthesis protein CbiD (cobalt-precorrin-5B C-methyltransferase) [Coenzyme ...
273-593
2.93e-141
Cobalamin biosynthesis protein CbiD (cobalt-precorrin-5B C-methyltransferase) [Coenzyme transport and metabolism]; Cobalamin biosynthesis protein CbiD (cobalt-precorrin-5B C-methyltransferase) is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Pssm-ID: 441507 [Multi-domain] Cd Length: 368 Bit Score: 414.12 E-value: 2.93e-141
CbiD; CbiD is essential for cobalamin biosynthesis in both S. typhimurium and B. megaterium, ...
273-507
8.41e-116
CbiD; CbiD is essential for cobalamin biosynthesis in both S. typhimurium and B. megaterium, no functional role has been ascribed to the protein. The CbiD protein has a putative S-AdoMet binding site. It is possible that CbiD might have the same role as CobF in undertaking the C-1 methylation and deacylation reactions required during the ring contraction process.
Pssm-ID: 460373 Cd Length: 258 Bit Score: 344.76 E-value: 8.41e-116
Precorrin-6x reductase CbiJ/CobK; This family consists of Precorrin-6x reductase EC:1.3.1.54. ...
2-226
2.16e-57
Precorrin-6x reductase CbiJ/CobK; This family consists of Precorrin-6x reductase EC:1.3.1.54. This enzyme catalyzes the reaction: precorrin-6Y + NADP(+) <=> precorrin-6X + NADPH. CbiJ and CobK both catalyze the reduction of macocycle in the colbalmin biosynthesis pathway.
Pssm-ID: 460596 Cd Length: 248 Bit Score: 193.06 E-value: 2.16e-57
cobalamin biosynthesis protein CbiD; This protein has been shown by cloning into E. coli to be ...
273-543
1.82e-48
cobalamin biosynthesis protein CbiD; This protein has been shown by cloning into E. coli to be required for cobalamin biosynthesis. role_id [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]
Pssm-ID: 273008 Cd Length: 347 Bit Score: 172.37 E-value: 1.82e-48
precorrin-6x reductase; This enzyme catalyzes a step in cobalamin biosynthesis. It has been ...
2-226
1.56e-26
precorrin-6x reductase; This enzyme catalyzes a step in cobalamin biosynthesis. It has been identified experimentally in Pseudomonas denitrificans and has been shown to be part of cobalamin biosynthetic operons in several other species. This enzyme was found to be a monomer by gel filtration. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]
Pssm-ID: 273231 Cd Length: 256 Bit Score: 108.78 E-value: 1.56e-26
D-ribose ABC transporter substrate-binding protein such as Thermoanaerobacter tengcongensis ...
148-222
1.42e-03
D-ribose ABC transporter substrate-binding protein such as Thermoanaerobacter tengcongensis ribose binding protein (ttRBP); Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs. Members of this group are belonging to the type 1 periplasmic binding protein superfamily, whose members are involved in chemotaxis, ATP-binding cassette transport, and intercellular communication in central nervous system. The thermophilic and mesophilic ribose-binding proteins are structurally very similar, but differ substantially in thermal stability.
Pssm-ID: 380622 [Multi-domain] Cd Length: 272 Bit Score: 40.77 E-value: 1.42e-03
Cobalamin biosynthesis protein CbiD (cobalt-precorrin-5B C-methyltransferase) [Coenzyme ...
273-593
2.93e-141
Cobalamin biosynthesis protein CbiD (cobalt-precorrin-5B C-methyltransferase) [Coenzyme transport and metabolism]; Cobalamin biosynthesis protein CbiD (cobalt-precorrin-5B C-methyltransferase) is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Pssm-ID: 441507 [Multi-domain] Cd Length: 368 Bit Score: 414.12 E-value: 2.93e-141
CbiD; CbiD is essential for cobalamin biosynthesis in both S. typhimurium and B. megaterium, ...
273-507
8.41e-116
CbiD; CbiD is essential for cobalamin biosynthesis in both S. typhimurium and B. megaterium, no functional role has been ascribed to the protein. The CbiD protein has a putative S-AdoMet binding site. It is possible that CbiD might have the same role as CobF in undertaking the C-1 methylation and deacylation reactions required during the ring contraction process.
Pssm-ID: 460373 Cd Length: 258 Bit Score: 344.76 E-value: 8.41e-116
Precorrin-6x reductase CbiJ/CobK; This family consists of Precorrin-6x reductase EC:1.3.1.54. ...
2-226
2.16e-57
Precorrin-6x reductase CbiJ/CobK; This family consists of Precorrin-6x reductase EC:1.3.1.54. This enzyme catalyzes the reaction: precorrin-6Y + NADP(+) <=> precorrin-6X + NADPH. CbiJ and CobK both catalyze the reduction of macocycle in the colbalmin biosynthesis pathway.
Pssm-ID: 460596 Cd Length: 248 Bit Score: 193.06 E-value: 2.16e-57
cobalamin biosynthesis protein CbiD; This protein has been shown by cloning into E. coli to be ...
273-543
1.82e-48
cobalamin biosynthesis protein CbiD; This protein has been shown by cloning into E. coli to be required for cobalamin biosynthesis. role_id [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]
Pssm-ID: 273008 Cd Length: 347 Bit Score: 172.37 E-value: 1.82e-48
precorrin-6x reductase; This enzyme catalyzes a step in cobalamin biosynthesis. It has been ...
2-226
1.56e-26
precorrin-6x reductase; This enzyme catalyzes a step in cobalamin biosynthesis. It has been identified experimentally in Pseudomonas denitrificans and has been shown to be part of cobalamin biosynthetic operons in several other species. This enzyme was found to be a monomer by gel filtration. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]
Pssm-ID: 273231 Cd Length: 256 Bit Score: 108.78 E-value: 1.56e-26
D-ribose ABC transporter substrate-binding protein such as Thermoanaerobacter tengcongensis ...
148-222
1.42e-03
D-ribose ABC transporter substrate-binding protein such as Thermoanaerobacter tengcongensis ribose binding protein (ttRBP); Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs. Members of this group are belonging to the type 1 periplasmic binding protein superfamily, whose members are involved in chemotaxis, ATP-binding cassette transport, and intercellular communication in central nervous system. The thermophilic and mesophilic ribose-binding proteins are structurally very similar, but differ substantially in thermal stability.
Pssm-ID: 380622 [Multi-domain] Cd Length: 272 Bit Score: 40.77 E-value: 1.42e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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