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Conserved domains on  [gi|742393757|ref|WP_038872883|]
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multidrug efflux MFS transporter MdtH [Cronobacter dublinensis]

Protein Classification

MFS transporter( domain architecture ID 11485445)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
1-400 0e+00

multidrug efflux MFS transporter MdtH;


:

Pssm-ID: 183255  Cd Length: 400  Bit Score: 719.53  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757   1 MSSVSQARSLGKYFLLIDNMLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIV 80
Cdd:PRK11646   1 MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  81 TGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQ 160
Cdd:PRK11646  81 TGMLMRAAGFATMAIAHEPWLLWLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 161 YDFRLVCGVGALLFVLCAGFNAWLLPDWKLSTVRTPLREGMGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPVMVNDIAG 240
Cdd:PRK11646 161 YDFRLVCATGAVLFVLAAAFNAWLLPAYKLSTVRTPVREGMTRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 241 EPAAVKWMYAIEAVLSLTLLYPLARWSEKRFRLEQRLMAGLLVMTLSLVPVGLASNLQQLFSLICLFYIGSIIAEPARET 320
Cdd:PRK11646 241 SPSAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLIMSLSMFPIGMVSNLQQLFTLICLFYIGSIIAEPARET 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 321 LSASLADARARGSYMGFSRLGLAFGGAFGYAGGGWLFDAGRALNTPELPWAMLGVIGIGTFLMLWWQFSHKRLAPGLVEQ 400
Cdd:PRK11646 321 LSASLADARARGSYMGFSRLGLALGGAIGYIGGGWLFDLGKALNQPELPWMMLGIIGLITLLALYWQFSQKRIARRMLER 400
 
Name Accession Description Interval E-value
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
1-400 0e+00

multidrug efflux MFS transporter MdtH;


Pssm-ID: 183255  Cd Length: 400  Bit Score: 719.53  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757   1 MSSVSQARSLGKYFLLIDNMLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIV 80
Cdd:PRK11646   1 MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  81 TGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQ 160
Cdd:PRK11646  81 TGMLMRAAGFATMAIAHEPWLLWLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 161 YDFRLVCGVGALLFVLCAGFNAWLLPDWKLSTVRTPLREGMGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPVMVNDIAG 240
Cdd:PRK11646 161 YDFRLVCATGAVLFVLAAAFNAWLLPAYKLSTVRTPVREGMTRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 241 EPAAVKWMYAIEAVLSLTLLYPLARWSEKRFRLEQRLMAGLLVMTLSLVPVGLASNLQQLFSLICLFYIGSIIAEPARET 320
Cdd:PRK11646 241 SPSAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLIMSLSMFPIGMVSNLQQLFTLICLFYIGSIIAEPARET 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 321 LSASLADARARGSYMGFSRLGLAFGGAFGYAGGGWLFDAGRALNTPELPWAMLGVIGIGTFLMLWWQFSHKRLAPGLVEQ 400
Cdd:PRK11646 321 LSASLADARARGSYMGFSRLGLALGGAIGYIGGGWLFDLGKALNQPELPWMMLGIIGLITLLALYWQFSQKRIARRMLER 400
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 13-388 9.02e-84

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 260.62  E-value: 9.02e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  13 YFLLIDNMLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFAT 92
Cdd:cd17329    2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  93 MAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQYDFRLVCGVGAL 172
Cdd:cd17329   82 LGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 173 LFVLCAGFNAWLLPDWKLSTVR---TPLREGMGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPVMVNDIAGEPA-AVKWM 248
Cdd:cd17329  162 LFLLAALVLLFLLPETRPKRRAaekTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGEsLLGLL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 249 YAIEAVLSLTLLYPLARWSEkRFRLEQRLMAGLLVMTLSLVPVGLASNLQQLFSLICLFYIGSIIAEPARETLSASLADA 328
Cdd:cd17329  242 LALNALLIVLLQFPVARLVE-RFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPP 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 329 RARGSYMGFSRLGLAFGGAFGYAGGGWLFDagraLNTPELPWAMLGVIGIGTFLMLWWQF 388
Cdd:cd17329  321 DKRGSYMGFYALAWGLGRAIGPLVGGLLLD----LLGPGLPWLILAALGLIAAALLLGLQ 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-337 1.73e-31

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 122.39  E-value: 1.73e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757   1 MSSVSQARSLGKYFLLIDNMLVVLGFFVVFPLISIrFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIV 80
Cdd:COG2814    1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  81 TGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQ 160
Cdd:COG2814   80 LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 161 Y-DFRLVCGVGALLFVLCAGFNAWLLPDwKLSTVRTPLREGMGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPVMVNDIA 239
Cdd:COG2814  160 LfGWRWVFLVNAVLALLALLLLLRLLPE-SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 240 GEPAAVKWMYAIEAVLSLTLLYPLARWSEKRFRLEQRLMAGLLVMTLSLVPVGLASNLQQLFSLICLFYIGSIIAEPARE 319
Cdd:COG2814  239 GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQ 318

                        330
                 ....*....|....*...
gi 742393757 320 TLSASLADARARGSYMGF 337
Cdd:COG2814  319 ALVAELAPPEARGRASGL 336
MFS_1 pfam07690
Major Facilitator Superfamily;
15-337 1.03e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 95.18  E-value: 1.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757   15 LLIDNMLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMA 94
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757   95 VAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLL-----QYDFRLVCGV 169
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAslfgwRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  170 GALLFVLCAGFNAWLLPDWKLSTVRTPLREGMG-RVLRDKRFVTYVLTLTGYYMLAVQVMLMLPVMVNDIAGEPAAVKWM 248
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAwKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  249 YAIEAVLSLTLLYPLARWSEKRFRLEQRLMA--GLLVMTLSLVPVGLASNLQQLFSLICLFYIGSIIAEPARETLSASLA 326
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAllLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320

                         330
                  ....*....|.
gi 742393757  327 DARARGSYMGF 337
Cdd:pfam07690 321 PKEERGTASGL 331
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 63-187 4.51e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 48.51  E-value: 4.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757   63 GIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMM 142
Cdd:TIGR00895  69 ALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFC 148

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 742393757  143 QDSAGAVTGALIGSWLL-QYDFRLVCGVGALLFVLCAGFNAWLLPD 187
Cdd:TIGR00895 149 GYPIGAAVGGFLAGWLIpVFGWRSLFYVGGIAPLLLLLLLMRFLPE 194
 
Name Accession Description Interval E-value
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
1-400 0e+00

multidrug efflux MFS transporter MdtH;


Pssm-ID: 183255  Cd Length: 400  Bit Score: 719.53  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757   1 MSSVSQARSLGKYFLLIDNMLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIV 80
Cdd:PRK11646   1 MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  81 TGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQ 160
Cdd:PRK11646  81 TGMLMRAAGFATMAIAHEPWLLWLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 161 YDFRLVCGVGALLFVLCAGFNAWLLPDWKLSTVRTPLREGMGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPVMVNDIAG 240
Cdd:PRK11646 161 YDFRLVCATGAVLFVLAAAFNAWLLPAYKLSTVRTPVREGMTRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 241 EPAAVKWMYAIEAVLSLTLLYPLARWSEKRFRLEQRLMAGLLVMTLSLVPVGLASNLQQLFSLICLFYIGSIIAEPARET 320
Cdd:PRK11646 241 SPSAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLIMSLSMFPIGMVSNLQQLFTLICLFYIGSIIAEPARET 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 321 LSASLADARARGSYMGFSRLGLAFGGAFGYAGGGWLFDAGRALNTPELPWAMLGVIGIGTFLMLWWQFSHKRLAPGLVEQ 400
Cdd:PRK11646 321 LSASLADARARGSYMGFSRLGLALGGAIGYIGGGWLFDLGKALNQPELPWMMLGIIGLITLLALYWQFSQKRIARRMLER 400
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 13-388 9.02e-84

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 260.62  E-value: 9.02e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  13 YFLLIDNMLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFAT 92
Cdd:cd17329    2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  93 MAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQYDFRLVCGVGAL 172
Cdd:cd17329   82 LGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 173 LFVLCAGFNAWLLPDWKLSTVR---TPLREGMGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPVMVNDIAGEPA-AVKWM 248
Cdd:cd17329  162 LFLLAALVLLFLLPETRPKRRAaekTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGEsLLGLL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 249 YAIEAVLSLTLLYPLARWSEkRFRLEQRLMAGLLVMTLSLVPVGLASNLQQLFSLICLFYIGSIIAEPARETLSASLADA 328
Cdd:cd17329  242 LALNALLIVLLQFPVARLVE-RFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPP 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 329 RARGSYMGFSRLGLAFGGAFGYAGGGWLFDagraLNTPELPWAMLGVIGIGTFLMLWWQF 388
Cdd:cd17329  321 DKRGSYMGFYALAWGLGRAIGPLVGGLLLD----LLGPGLPWLILAALGLIAAALLLGLQ 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-337 1.73e-31

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 122.39  E-value: 1.73e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757   1 MSSVSQARSLGKYFLLIDNMLVVLGFFVVFPLISIrFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIV 80
Cdd:COG2814    1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  81 TGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQ 160
Cdd:COG2814   80 LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 161 Y-DFRLVCGVGALLFVLCAGFNAWLLPDwKLSTVRTPLREGMGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPVMVNDIA 239
Cdd:COG2814  160 LfGWRWVFLVNAVLALLALLLLLRLLPE-SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 240 GEPAAVKWMYAIEAVLSLTLLYPLARWSEKRFRLEQRLMAGLLVMTLSLVPVGLASNLQQLFSLICLFYIGSIIAEPARE 319
Cdd:COG2814  239 GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQ 318

                        330
                 ....*....|....*...
gi 742393757 320 TLSASLADARARGSYMGF 337
Cdd:COG2814  319 ALVAELAPPEARGRASGL 336
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 15-382 9.04e-31

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 120.99  E-value: 9.04e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  15 LLIDNMLVVLGFFVVFPLISIrFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMA 94
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPA-LLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  95 VAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQY---DFRLVCGVGA 171
Cdd:cd06174   80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgfGWRAVFLIAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 172 LLFVLCAGFNAWLLPDWKLSTVR-------TPLREGMGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPVMVNDIAGEPAA 244
Cdd:cd06174  160 ALALLAAILLLLVVPDPPESARAkneeassKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVA 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 245 V-KWMYAIEAVLSLTLLYPLARWSEKRFRLEQRLMAGLLVMTLSLVPVGLASNLQQLFSLICLFYIGSIIAEPARETLSA 323
Cdd:cd06174  240 VaGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 742393757 324 SLADARARGSYMGFSRLGLAFGGAFGYAGGGWLFDAGRALNTPELPWAMLGVIGIGTFL 382
Cdd:cd06174  320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 15-339 9.59e-30

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 118.06  E-value: 9.59e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  15 LLIDNMLVVLGFFVVFPLISIrFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMA 94
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPL-YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  95 VAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQ-YDFRLVCGVGALL 173
Cdd:cd17325   80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADaLGYRAPFLVCAAL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 174 FVLCAGFNAWLLPD-----WKLSTVRTPLREGMGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPVMVNDIAG-EPAAVKW 247
Cdd:cd17325  160 ALLALVLALLLLPEprpppNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIGL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 248 MYAIEAVLSLTLLYPLARWSEKRFRLEQrLMAGLLVMTLSLVPVGLASNLQQLFSLICLFYIGSIIAEPARETLSASLAD 327
Cdd:cd17325  240 LFGAQGLASALSQPPAGKLSDRIGRKPL-ILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVP 318

                        330
                 ....*....|..
gi 742393757 328 ARARGSYMGFSR 339
Cdd:cd17325  319 PEGRGTAMGLFN 330
MFS_1 pfam07690
Major Facilitator Superfamily;
15-337 1.03e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 95.18  E-value: 1.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757   15 LLIDNMLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMA 94
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757   95 VAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLL-----QYDFRLVCGV 169
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAslfgwRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  170 GALLFVLCAGFNAWLLPDWKLSTVRTPLREGMG-RVLRDKRFVTYVLTLTGYYMLAVQVMLMLPVMVNDIAGEPAAVKWM 248
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAwKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  249 YAIEAVLSLTLLYPLARWSEKRFRLEQRLMA--GLLVMTLSLVPVGLASNLQQLFSLICLFYIGSIIAEPARETLSASLA 326
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAllLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320

                         330
                  ....*....|.
gi 742393757  327 DARARGSYMGF 337
Cdd:pfam07690 321 PKEERGTASGL 331
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 20-180 8.80e-19

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 86.86  E-value: 8.80e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  20 MLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEP 99
Cdd:cd17325  209 FVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 100 WVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQ-YDFRLVCGVGALLFVLCA 178
Cdd:cd17325  289 WLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDaFGFATPFLAAAALLLLAA 368


                 ..
gi 742393757 179 GF 180
Cdd:cd17325  369 VL 370
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 62-336 4.18e-18

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 84.93  E-value: 4.18e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  62 LGIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLM 141
Cdd:cd17474   50 LMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYE 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 142 MQDSAGAVTGALIGSWLLQYDFRLVCGVGALLFVLCAGFNAWLLPDWKLSTVRTP--LREGMGRVLRDKRFVTYVLTLTG 219
Cdd:cd17474  130 AALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSatKLRDLKKALRGRGLLTFLVSAFL 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 220 YYMLAVQVMLMLPVMVNDIAGEPAAVK-WMYAIEAVLSLTLLYPLARWSEKRFRLEQRLMAGLLVMTLSLVPVGLASNLQ 298
Cdd:cd17474  210 YFFLYFAFLTYLPFLLELLYGISPIIIgLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLA 289

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 742393757 299 QLFSLICLFYIGSIIAEPARETLSASLADARARGSYMG 336
Cdd:cd17474  290 LLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASS 327
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 24-336 1.08e-17

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 83.80  E-value: 1.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  24 LGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWVLW 103
Cdd:cd17472   10 LGMFLVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLI 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 104 VSCVLSGLGGtlFDPPRSALVVKLVRPQERGRFFSLLmmqdsaGAVTG-----ALIGSWLLQ--YDFRLVCGVGALLFVL 176
Cdd:cd17472   90 LGRALQGSGA--ISSVVMALLADLTREENRTKAMALI------GASIGiafaiSMVLGPLLAahLGVSGLFLITAILSLV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 177 CAGFNAWLLPDWKLS-TVRTPLREGMGRVLRDKRFVtyVLTLTGYYMLAVQVM--LMLPVMVNDIAGEPAAVKWMYAIEA 253
Cdd:cd17472  162 SLLILLFFVPDPPKIvQISEKEKKKLKKLLKNKRLL--RLDFSIFILHFVLMAffYILPLLLTQLGGGKGQLWKVYLPAI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 254 VLSLTLLYPLARWSEKRFRLEQRLMAGLLVMTLSLVPVGLAS-NLQQLFSLICLFYIGSIIAEPARETLSASLADARARG 332
Cdd:cd17472  240 LIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAAtSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRG 319


                 ....
gi 742393757 333 SYMG 336
Cdd:cd17472  320 TAMG 323
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 45-387 1.13e-16

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 80.74  E-value: 1.13e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  45 ALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAH-----EPWVLWVSCVLSGLGGTLFDPP 119
Cdd:cd06173   33 ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAllgslSLWLLLVLAFLLGIASAFFGPA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 120 RSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQ-YDFRLVCGVGALLFVLCAGFNAWLLPDWKLSTVRTP-- 196
Cdd:cd06173  113 RQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVAlLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSsl 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 197 ----LREGMGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPVMVNDIAGEPAAVK-WMYAIEAVLSLTLLYPLARWSeKRF 271
Cdd:cd06173  193 llrdLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYgLLLAAFGVGALLGALLLGRLS-KRR 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 272 RLEQRLMAGLLVMTLSLVPVGLASNLQQLFSLICLFYIGSIIAEPARETLSASLADARARGSYMGFSRLGLAFGGAFGYA 351
Cdd:cd06173  272 RRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGAL 351

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 742393757 352 GGGWLFDAGralnTPELPWAMLGVIGIGTFLMLWWQ 387
Cdd:cd06173  352 LAGLLADAL----GLSAVFLLAGALLLLAALLLLLL 383
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
20-337 2.03e-16

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 79.91  E-value: 2.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  20 MLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEP 99
Cdd:COG2271   19 YFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSF 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 100 WVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQ-YDFRLVCGVGALLFVLCA 178
Cdd:COG2271   99 WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAaFGWRAAFLILGLPGLLLA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 179 GFNAWLLpdwklstvrtplregmgrvlrdkrFVTYVLTLTGYYMLAVQvmlmLPVMVNDIAG-EPAAVKWMYAIEAVLSL 257
Cdd:COG2271  179 LLRFWLL------------------------ALAYFLVYFALYGFLTW----LPTYLVEVRGlSLAQAGLLLSLPFLAGI 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 258 TLLYPLARWSEKRFRLEQRLMA-GLLVMTLSLVPVGLASNLQQLFSLICLFYIGSIIAEPARETLSASLADARARGSYMG 336
Cdd:COG2271  231 VGSLLGGWLSDRLGRRRKLVLAiGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASG 310


                 .
gi 742393757 337 F 337
Cdd:COG2271  311 L 311
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
20-392 3.60e-16

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 79.54  E-value: 3.60e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  20 MLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEP 99
Cdd:COG2223   14 FFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSY 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 100 WVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQ-YDFRLVCGVGALLFVLCA 178
Cdd:COG2223   94 WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAaFGWRNAFLILGILLLVVA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 179 GFNAWLL---PDWKLSTVRTPLREgMGRVLRDKRF----VTYVLTLTGYYMLAVQvmlmLPVMVNDIAGEPAAVKWMYAI 251
Cdd:COG2223  174 VLAWLFLrdpPAGAAAAAKASLRD-QLEALRDPRFwllsLLYFGTFGSFIGFSSW----LPPYLVDQFGLSAATAGLLAA 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 252 EAVLSLTLLYPLARWSEKRFRLEQRLMAGLLVMTLSLVPVGLAS-NLQQLFSLICLFYIGSIIAEPARETLSASLADARA 330
Cdd:COG2223  249 LFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKN 328

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 742393757 331 RGSYMGFSRLGLAFGGAFGYAGGGWLFDagrALNTPELPWAMLGVIGIGTFLMLWWQFSHKR 392
Cdd:COG2223  329 AGAVYGLVGAAGGLGGFLGPLLFGALLD---ATGSYTAAFLVFAVLALVALVLTLLLYRRPR 387
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 41-337 1.54e-15

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 77.20  E-value: 1.54e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  41 LGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGAR-PMIVTGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPP 119
Cdd:cd17370   29 LGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRkPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPP 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 120 RSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQY---DFRLVCGVGALLFVLCAGFNAWLLPDWKLSTVRTP 196
Cdd:cd17370  109 RDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLlggNYRTIFLLAAIPALLALLILLFVVKEYPRPPKLRK 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 197 LREGMGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLpVMVNDIAGEPAAVKWMYAIEAVLSLTLLYPLARWSEkRFRLEQR 276
Cdd:cd17370  189 KSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLI-LRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSD-RIGRKKL 266

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 742393757 277 LMAGLLVMTLSLVPVGLASNLQQLFSLICLFYIGSIIAEPARETLSASLADARARGSYMGF 337
Cdd:cd17370  267 LILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGL 327
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 15-303 1.97e-14

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 74.12  E-value: 1.97e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  15 LLIDNMLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGAR-PMIVTGMLLRAAGFATM 93
Cdd:cd17471    1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRkPLILLALLAGALGYLLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  94 AVAHEPWV-LWVSCVLSGLGGTLFdPPRSAL---VVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLL-QYDFRLVCG 168
Cdd:cd17471   81 AFLRNYWVlLLVGVVLLSLGAAAF-PQLFALareYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLdVLGFTGLFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 169 VGALLFVLCAGFNAWLLPDWKLSTVRTPLREGMGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLP-VMVNDIAGEPAAVKW 247
Cdd:cd17471  160 LAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPlYVTNELGGSESWVGL 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 742393757 248 MYAIEAVLSLTLLYPLARWSeKRFRLEQRLMAGLLVMTLSLVPVGLASNLQQLFSL 303
Cdd:cd17471  240 LFGLAAALEIPIMLLAGLLA-KRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIAL 294
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 24-338 7.70e-13

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 69.14  E-value: 7.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  24 LGFFVVFPLIS--IRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWV 101
Cdd:cd17330   10 LGFGIVFPVLPfyVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 102 LWVSCVLSGLGGTLFdPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQ-YDFRLVCGVGALLFVLCAGF 180
Cdd:cd17330   90 LFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTpYGYALPFLVAAALALLNLVL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 181 NAWLLPDWKLStvrtplregmgrvlrdkrFVTYVLTLTGYYMLAVQVMLMLPVMVNDiagEPAAVKWMYAIEAVLSLTLL 260
Cdd:cd17330  169 VLFFLPPLRRL------------------LLVYFLIALAFAGLESVFSLFLKDRFGF---SPSQIGLLLALVGIAGILAQ 227

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 742393757 261 YPLARWSEKRFRLEQRLMAGLLVMTLSLVPVGLASNLQQLFSLICLFYIGSIIAEPARETLSASLADARARGSYMGFS 338
Cdd:cd17330  228 LLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGII 305
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
24-360 7.93e-12

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 66.46  E-value: 7.93e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  24 LGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGAR-----PMIVTGMLLRAAGFATMAVAHE 98
Cdd:COG2211   24 LAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrPWILIGAIPLALSFVLLFTAPD 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  99 P------WVLWVSCVLSGLGGTLFDPPRSALVVKLVR-PQERGRFFSLLMMQDSAGAVTGALIGSWLLQY-------DFR 164
Cdd:COG2211  104 LsptgklIYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaalGYR 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 165 LVCGVGALLFVLCAGFNAWLLPDWKLSTV-RTPLREGMGRVLRDKRFVTYVL-TLTGYYMLAVQVMLMLPVMVNDIAGEP 242
Cdd:COG2211  184 LTALIFAVLGLLAFLLTFFGTKERPVPEEeKVSLKESLKALLKNRPFLLLLLaYLLFFLALALVAALLLYYFKYVLGLSA 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 243 AAVKWMYAIEAVLSLTLLYPLARWSeKRFRLEQRLMAGLLVMTLSLVPVGLA--SNLQQLFSLICLFYIGSIIAEPARET 320
Cdd:COG2211  264 ALVGLLLALYFLAALLGAPLWPRLA-KRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWA 342

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 742393757 321 LSASLADA-------RARGSYMGFSRLGLAFGGAFGYAGGGWLFDAG 360
Cdd:COG2211  343 MLADVVDYdewktgrRREGLYFGIFTFAIKLGQALAGALAGLLLALF 389
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 15-336 1.20e-11

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 65.69  E-value: 1.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  15 LLIDNMLVVLGFFVVFPLISIrFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMA 94
Cdd:cd17489    1 ILLANFFFFLSFYLLLPVLPL-YAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  95 VAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQ-YDFRLVCGVGALL 173
Cdd:cd17489   80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQhLGFAVLFIVAAVL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 174 FVLCAGFNAWLLPDWKLSTVRTPLREGMGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPVMVNDIagePAAVKWMYAIEA 253
Cdd:cd17489  160 ALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAER---GISNAGLFFTVY 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 254 VLSLTLLYPLARWSEKRFRLEQRLMAGLLVMTLSLVPVGLASNLQQLFSLICLFYIGSIIAEPARETLSASLADARARGS 333
Cdd:cd17489  237 AIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGA 316


                 ...
gi 742393757 334 YMG 336
Cdd:cd17489  317 ANG 319
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
63-310 1.23e-11

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 65.65  E-value: 1.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  63 GIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVrPQERGRFFSLLMM 142
Cdd:COG0738   60 SLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHA 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 143 QDSAGAVTGALIGSWLLQYDF-----RLVCGVGALLFVLCAGFNAWLLPDWKL-STVRTPLREGMGRVLRDKRFVTYVLT 216
Cdd:COG0738  139 FFSLGALLGPLLGGLLILLGLslswhLPYLILAVLLLLLALLFLRSKLPEIEEeEEEAAGSAASLKSLLKNPRLLLGGLA 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 217 LTGYYMLAVQVMLMLPVMVNDIAGEPAAVKWMYAIEAVLSLTLLYPLARWSEKRFRLEQRLMAGLLVMTLSLVPVGLASN 296
Cdd:COG0738  219 IFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPG 298

                        250
                 ....*....|....
gi 742393757 297 LqqLFSLICLFYIG 310
Cdd:COG0738  299 P--WLALIGLALVG 310
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 15-386 2.00e-10

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 61.90  E-value: 2.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  15 LLIDNMLVVLGFFVVFPLISIRFvdnlGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMA 94
Cdd:cd17355   11 ILILSWGIRYYFGVFIIPIIAEF----GWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  95 VAHEPWVLWVS-CVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLL-QYDFRLVCGVGAL 172
Cdd:cd17355   87 LATSLWQLYLLwGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIeAFGWRTALLVLAL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 173 LFVLCAGFNAWLLPDWKLSTVRTP--------LREGMGRVLRDKRFVTYVLT--LTGYYMLAVQVmlMLPVMVNDIAGEP 242
Cdd:cd17355  167 LALLVLVPVLLLLRRRPADLALRAyddaspasPGSTLKEALRSASFWLLALAffLCGFAVVGLIV--HLVPYLADRGISP 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 243 AAVKWMYAIEAVLSLtLLYPLARWSEKRFRLEQRLMAGLLVMTLSLVPVGLASNLQQLFSLICLFYIGSIIAE-PARETL 321
Cdd:cd17355  245 AAAAVALALIGLFNI-VGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATvPLTAAL 323

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 742393757 322 SASLADARARGSYMGFSRLGLAFGGAFGYAGGGWLFDagrALNTPELPWAMLGVIGIGTFLMLWW 386
Cdd:cd17355  324 AARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYD---RTGSYTAAWALAVALGLIAALLVLP 385
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
41-286 1.97e-09

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 58.73  E-value: 1.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  41 LGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPPR 120
Cdd:COG2807   48 LGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 121 SALvVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQ-YDFRLVCGVGALLFVLCAGFNAWLLPDWKLSTVRTPLRE 199
Cdd:COG2807  128 PGL-IKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAaLGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAA 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 200 GMGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPVMVNDIAGEPAAVKWMYAIEAVLSLTLLYPLARWSEkRFRLEQRLMA 279
Cdd:COG2807  207 SLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLAD-RLGDRRPLLL 285


                 ....*..
gi 742393757 280 GLLVMTL 286
Cdd:COG2807  286 LLGLLGL 292
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 19-292 2.85e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 57.90  E-value: 2.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  19 NMLVVLGFFVVFPLISIrFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHE 98
Cdd:COG0477   23 TFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPS 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  99 PWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQY-DFRLVCGVGALLFVLc 177
Cdd:COG0477  102 PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAlGWRWIFLINAPLGLL- 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 178 AGFNAWLLPDWKLSTVRTPLREGMGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPVMVNDIAGEPAAVKWMYAIEAVLSL 257
Cdd:COG0477  181 ALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLA 260

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 742393757 258 TLLYPLARWSEKRFRLEQRLMAGLLVMTLSLVPVG 292
Cdd:COG0477  261 ALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 67-333 7.21e-09

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 57.17  E-value: 7.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  67 GAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSA 146
Cdd:cd17324   55 GPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTL 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 147 GAVTGALIGSWLLQY-DFRLVCGVGALLFVLCAGFNAWLLPDWKLST-VRTPLREGMGRVLRDKR-FVTYVLTLTGYYML 223
Cdd:cd17324  135 GLVLGRPLGGLLGQLlGWRAAFLAIAVLALLAALLLWRLLPSLPPKKpGSLGLLSSLLLLLRNPRlRLAYLITFLLFGGF 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 224 AVQVMLMLPVMVNDIAGEPAAVKWMYAIEAVLSLTLLYPLARWSEKRFRLeQRLMAGLLVMTLSLVPVGLASNLQQLFSL 303
Cdd:cd17324  215 FALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRR-ALLIALLLLAAALLLLTLLGPSPLLLLVG 293

                        250       260       270
                 ....*....|....*....|....*....|.
gi 742393757 304 ICLFYIGSIIAEPARETLSASLA-DARARGS 333
Cdd:cd17324  294 LVLWGLGFFAAHSALQTRVLRLApEARGLAS 324
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 13-178 1.04e-08

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 56.43  E-value: 1.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  13 YFLLIDNMLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFAT 92
Cdd:cd17473  200 LPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLL 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  93 MAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQYD------FRLV 166
Cdd:cd17473  280 LALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTgglsgaFLIL 359

                        170
                 ....*....|..
gi 742393757 167 CGVGALLFVLCA 178
Cdd:cd17473  360 GVLALVLAIVLL 371
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 64-185 1.14e-08

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 56.41  E-value: 1.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  64 IFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQ 143
Cdd:cd17321   49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAV 128

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 742393757 144 DSAGAVTGALIGSWLLQYD-----FRLVCGVGALLFVLCAGFNAWLL 185
Cdd:cd17321  129 VGIGAALGPLLGGLLLELFgwrwiFLINVPIGLVALLLARTFSGAVL 175
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
19-189 5.41e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 54.11  E-value: 5.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  19 NMLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGAR--PMIVTGMLLRAAGFATMAVA 96
Cdd:COG2271  189 YFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALL 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  97 HEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLL-MMQDSAGAVTGALIGSWLLQYDFRLVCGVGALLFV 175
Cdd:COG2271  269 PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVnTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALAL 348

                        170
                 ....*....|....
gi 742393757 176 LCAGFNAWLLPDWK 189
Cdd:COG2271  349 LAALLALLLLRETR 362
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 15-337 5.51e-08

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 54.12  E-value: 5.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  15 LLIDNMLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMA 94
Cdd:cd17473    4 LLLASTLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  95 VAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQYDFRLVCGVGALLF 174
Cdd:cd17473   84 FLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLAL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 175 VLcAGFNAWLLPDWKLSTVRTPLREGMGRVLRDKRFVTYVLTLTGYYMLAV-QVMLMLPVMVNDIAGEPAAVKWMYAIEA 253
Cdd:cd17473  164 PV-LILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFyVIPIQLPFLLQERGGGSAALIGLALAIA 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 254 VLSLTLLYPLARWSEKRFRLEQRLMAGLLVMTLSLVPVGLASNLQQLFSLICLFYIGSIIAEPARETLSASLADARARGS 333
Cdd:cd17473  243 SLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGR 322


                 ....
gi 742393757 334 YMGF 337
Cdd:cd17473  323 AMGI 326
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 44-314 5.78e-08

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 54.12  E-value: 5.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  44 AALMVGIALGLrqlvqqglgIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSAL 123
Cdd:cd17320   41 SAYLLGFALGQ---------LLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 124 VVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLL-----QYDFRLVCGVGALLFVLCAGFNAWLLPDWKLSTVRTPLR 198
Cdd:cd17320  112 VRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLlffgwRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 199 EGMGRVLRDKRFVTYVLTLTGYY-MLAVQVMLMLPVMVNDIAGEPAAVKWMYAIEAVLSLtLLYPLARWSEKRFRLEQRL 277
Cdd:cd17320  192 RAYKRVLKNRRFLGYALALGLSFaGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALI-LGSLLNGRLVRRFGPRRLL 270

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 742393757 278 MAGLLVMTLSLVpVGLASNLQQLFSLICLFYIGSIIA 314
Cdd:cd17320  271 RLGLLLLLAAAL-VLLLAALLGGLSLWPLVAPLFLIF 306
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
20-173 9.18e-08

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 54.05  E-value: 9.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  20 MLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLvqqgLGIFGGAIADR-LGARPMIVTGMLLRAAGFATMAVAHE 98
Cdd:COG3104   33 MRAILVLYLTASLADGGLGLSEADAAAIYGAYTALVYL----TPLLGGWLADRlLGQRRAILLGGILMALGHFLLALPGG 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  99 PWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGR--FFSLLMMQDSAGAVTGALIGSWLLQ-YDFR---LVCGVGAL 172
Cdd:COG3104  109 VTLFYLGLALIAVGNGLFKPNISSLVGQLYDPGDPRRdaGFTIFYMGINIGAFLAPLLCGYLGEkYGWHygfGAAAIGML 188


                 .
gi 742393757 173 L 173
Cdd:COG3104  189 I 189
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 8-158 9.52e-08

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 53.70  E-value: 9.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757   8 RSLGKYFLLIdnmLVVLGFFVV----FPLISIRFVDnLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGM 83
Cdd:cd17370  196 KKLPKAFWLY---LLAVALFALgnfsFAFLILRAQE-LGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGY 271

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 742393757  84 LLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLmmqdSAGAVTGALIGSWL 158
Cdd:cd17370  272 LSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLF----NTVVGIGWLLASLI 342
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
 44-173 1.03e-07

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 53.35  E-value: 1.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  44 AALMVGIALGLrqlvQQGLGIFGGAIADR-LGARPMIVTGMLLRAAGFATMAVA-HEPWVLWVSCVLSGLGGTLFDPPRS 121
Cdd:cd17346   42 AASIYGAYTAL----VYLTPIIGGWLADKvLGARRTVFIGGILMALGYLLLALSpFSVSMLYLGLALIIVGNGLFKPNIS 117

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 742393757 122 ALVVKLVRPQE--RGRFFSLLMMQDSAGAVTGALIGSWL-LQYDFR---LVCGVGALL 173
Cdd:cd17346  118 SLVGKLYDENDprRDSGFSIFYMGINLGAFLAPLLCGTLgDNYGYHygfGLAAVGMLL 175
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 15-337 1.67e-07

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 52.61  E-value: 1.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  15 LLIDNMLVVLGFFVVFPLISIrFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGAR-PMIVTGMLLRAAGFATM 93
Cdd:cd17490    1 FLIIVFLFWFSQYVYVPFLSP-YAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRkLFIIIGLLFTVLASLIM 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  94 AVAHEPWVLWVSCVLSGLGGTLFdPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGS-----WLLQYDFRLVCG 168
Cdd:cd17490   80 ILFPSPWGLLIARFLSGIAAATW-VSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGliaehFGMRAPFLLAAL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 169 VGALLFVLCAGFNAWLLPDWKLSTVRTPLREgmgrVLRDKRFVTY-VLTLTGYYMLAVQVMLMLPVMVNDIAGEPAAVKW 247
Cdd:cd17490  159 AGVLGFILSLFIKEERREKKPVLTELKELLS----VLKDKKLLFFsLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 248 ---MYAIEAVLSLTLLYPLARwseKRFRLEQRLMAGLLVMTLSLVPVGLASNLQQLFSLICLFYIGSIIAEPARETLSAS 324
Cdd:cd17490  235 lsiIYLLPNALASLLSGTLFY---KKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIE 311

                        330
                 ....*....|...
gi 742393757 325 LADARARGSYMGF 337
Cdd:cd17490  312 GVPAEQRSTAMGF 324
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 39-177 3.43e-07

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 51.87  E-value: 3.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  39 DNLGWAALMVGIAL---GLRQLVQQGLGIfgGAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGtL 115
Cdd:cd17388  235 DRFDWSPTMVGLSLavfGLLHALFQAFVT--GPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGG-I 311

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 742393757 116 FDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQYDFRLVCG----VGALLFVLC 177
Cdd:cd17388  312 AGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGlawiIGAALYLIC 377
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 19-180 3.82e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 51.85  E-value: 3.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  19 NMLVVLGFFVVFPLISirfVDNLGWAALMVGIALGLrqlvqQGLGIFGGAI-----ADRLGARPMIVTGMLLRAAGFATM 93
Cdd:cd06173  220 FALLGGALTVLLPLLA---KEVLGGGAAGYGLLLAA-----FGVGALLGALllgrlSKRRRRGRLLLIGALLLGLALLVL 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  94 AVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQ-YDFRLVCGVGAL 172
Cdd:cd06173  292 GLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADaLGLSAVFLLAGA 371


                 ....*...
gi 742393757 173 LFVLCAGF 180
Cdd:cd06173  372 LLLLAALL 379
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 48-338 4.68e-07

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 51.47  E-value: 4.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  48 VGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKL 127
Cdd:cd17475   33 VGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRW 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 128 VRPQERGRFFSLLMMQDSAGAVTGALIGSWL-LQYDFRLVCGVGALLFVLCAGFNAWLLPDWKLSTVRTP----LREGMG 202
Cdd:cd17475  113 FPPRERGLAMGIRQTGVPLGGALAAALLPPLaLHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATEsastLLRSLK 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 203 RVLRDKRFvtYVLTLTGYYMLAVQVMLM--LPVMVNDIAG-EPAAVKWMYAIEAVLSLTLLYPLARWSEKRFRLEQRLMA 279
Cdd:cd17475  193 EVLRNRDV--WLIAIAGALLVAPQFALLtfLLLFLHDHLGlSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVL 270

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 742393757 280 GLLVMTLSLVPVGLASNLQQ-----LFSLICLFYIGSIIAEPARETLSASLADARARGSYMGFS 338
Cdd:cd17475  271 VITAAIAAAALLVLSLLSPGtplwlLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLA 334
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 20-176 6.53e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 51.01  E-value: 6.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  20 MLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEP 99
Cdd:cd17324  208 FLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSP 287

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 742393757 100 WVLWVSCVLSGLGGTLFDPPRSALVVKLVrPQERGRFFSLLMMQDSAGAVTGALIGSWLLQ-YDFRLVCGVGALLFVL 176
Cdd:cd17324  288 LLLLVGLVLWGLGFFAAHSALQTRVLRLA-PEARGLASSLYLAAYNLGGALGAALGGLVLDhGGWAGVGWVGAALLLL 364
MFS_1 pfam07690
Major Facilitator Superfamily;
12-152 7.11e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 50.88  E-value: 7.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757   12 KYFLLIDNMLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRA---A 88
Cdd:pfam07690 201 PVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIlaaL 280

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 742393757   89 GFATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGA 152
Cdd:pfam07690 281 GLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 41-337 1.22e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 49.88  E-value: 1.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  41 LGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPPR 120
Cdd:cd17319   33 LGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 121 SALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLL-----QYDFRLVCGVGALLFVLCAgfnaWLLPdwklstvrt 195
Cdd:cd17319  113 IKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLllfgwRWAFIIEGLLGLLLAVLWW----FYLR--------- 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 196 plregmgrvlrdkRFVTYVLTLTGYYMLAVQVMLMLPVMVNDIAG-EPAAVKWMYAIEAVLSLTLLYPLARWSEKRFRLE 274
Cdd:cd17319  180 -------------QVWGLALGYFGINYALYGLLTWLPTYLKQARGfSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGA 246

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 742393757 275 QRL--MAGLLVMTLSLVPVGLASNLQQLFSLICLFYIGSIIAEPARETLSASLADARARGSYMGF 337
Cdd:cd17319  247 RRLviIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGL 311
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
14-161 1.41e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 49.90  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  14 FLLIDNMLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATM 93
Cdd:COG2211  232 LLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 742393757  94 AVA--HEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQE-------RGRFFSLLMMQDSAGAVTGALIGSWLLQY 161
Cdd:COG2211  312 FFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLAL 388
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 14-336 2.66e-06

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 49.17  E-value: 2.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  14 FLLIDNMLVVLGFFVVFPLIS---IRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGF 90
Cdd:cd17388    3 FILVTVLLDAMGIGLIMPVLPtllREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  91 ATMAVAHEPWVLWVSCVLSGLGGTLFdPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQYDFRLVCGVG 170
Cdd:cd17388   83 LLMAFAPTLWWLYLGRIIAGITGATG-AVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 171 ALLFVLCAGFNAWLLPDWKLSTVRTPLREGMGRVLRDKRFVTYVLTLTGyyMLAVQVMLML----PVMVNDIAGE----- 241
Cdd:cd17388  162 AGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGFPGLLG--LLAVFFLIQLigqvPATTWVLFTEdrfdw 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 242 -PAAVKWMYAIEAVLSLTLLYPLARWSEKRFRLEQRLMAGLLVMTLSLVPVGLASNLQQLFSLICLFYIGSiIAEPARET 320
Cdd:cd17388  240 sPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGG-IAGPALQG 318

                        330
                 ....*....|....*.
gi 742393757 321 LSASLADARARGSYMG 336
Cdd:cd17388  319 LLSRQVPENEQGELQG 334
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 15-180 2.94e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 48.73  E-value: 2.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  15 LLIDNMLVVLGFFVVFPLISIRFVDNLGWAALMVGIAL---GLRQLVQQGLgiFGGAIADRLGARPMIVTGMLLRAAGFA 91
Cdd:cd17330  179 LLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLalvGIAGILAQLL--LIPRLAKRLGERKLLRLGLLLAIIGLL 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  92 TMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQ-YDFRLVCGVG 170
Cdd:cd17330  257 LLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSfLGPGVPFLLA 336

                        170
                 ....*....|
gi 742393757 171 ALLFVLCAGF 180
Cdd:cd17330  337 AGLLLIALFL 346
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 16-156 3.19e-06

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 48.73  E-value: 3.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  16 LIDNMLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMAV 95
Cdd:cd17503  184 LLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAF 263

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 742393757  96 AHEPWVLW---VSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLL-MMQDSAGAVTGALIGS 156
Cdd:cd17503  264 LTPDTSLWliiLPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFnTIRQLGGSIGTALLAT 328
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 19-158 4.42e-06

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 48.32  E-value: 4.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  19 NMLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHE 98
Cdd:cd17321  177 AFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGA 256

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 742393757  99 P---WVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLL-MMQDSAGAVTGALIGSWL 158
Cdd:cd17321  257 DssvWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILnTARQLGGALGVALLGALL 320
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 63-187 4.51e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 48.51  E-value: 4.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757   63 GIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMM 142
Cdd:TIGR00895  69 ALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFC 148

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 742393757  143 QDSAGAVTGALIGSWLL-QYDFRLVCGVGALLFVLCAGFNAWLLPD 187
Cdd:TIGR00895 149 GYPIGAAVGGFLAGWLIpVFGWRSLFYVGGIAPLLLLLLLMRFLPE 194
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 24-194 6.59e-06

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 47.61  E-value: 6.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  24 LGFFVVFPLISIRFVDnLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWVLW 103
Cdd:cd17390   10 FGVSMILPLLSTHIRS-LGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 104 VSCVLSGL-GGTLfdPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQYD--FRLVCGVGALLFVLCAGF 180
Cdd:cd17390   89 LSRIPLGIfKHTQ--SLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDggFYYVALLCSAIFILNAGL 166

                        170
                 ....*....|....*
gi 742393757 181 NAWLLPD-WKLSTVR 194
Cdd:cd17390  167 VWFLLSKlWDLLLVR 181
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 13-176 1.01e-05

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 47.21  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  13 YFLLIDNMLVVLGFFVVFPLISIRFVDNLGWAALMVGI---ALGLRQLVQQGLGIfgGAIADRLGARPMIVTGMLLRAAG 89
Cdd:cd17331  210 AFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYlmsYAGVLGMVVQGLLV--GPLTKRFGERSLLKLSVALLAIG 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  90 FATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQ-YDFRLVCG 168
Cdd:cd17331  288 YLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQaYGFPSFGL 367


                 ....*...
gi 742393757 169 VGALLFVL 176
Cdd:cd17331  368 LGAAINGL 375
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 15-185 1.07e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 47.26  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  15 LLIDNMLVVLGFFVVFPLISI------RFVDNLGWAALMVGIALGLRQLVqqgLGIFGGAIADRLGARPMIVTGMLLRAA 88
Cdd:cd17391  206 LFVTTFIIQLANQSIEPILTLyirqlmGDASNLAFISGLVFSATGVSSLL---SAPRLGKLGDRIGHHRILLGALLASAL 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  89 GFATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWL-LQYDFRLVC 167
Cdd:cd17391  283 LYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIaAHFGYRAVF 362

                        170
                 ....*....|....*...
gi 742393757 168 GVGALLFVLCAGFNAWLL 185
Cdd:cd17391  363 VVTALLVLLNAIWSFIFL 380
PRK12382 PRK12382
putative transporter; Provisional
 24-179 2.08e-05

putative transporter; Provisional


Pssm-ID: 183487 [Multi-domain]  Cd Length: 392  Bit Score: 46.21  E-value: 2.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  24 LGFFVVFPLISIRFVDNlGWAalMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWVLW 103
Cdd:PRK12382 230 VGFAVIGTFVSLYFASK-GWA--MAGFTLTAFGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVAL 306

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 742393757 104 VSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLL-MMQDSAGAVTGALIGSWLLQYDFRLVCGVGALLFVLCAG 179
Cdd:PRK12382 307 AGAALTGAGCSLIFPALGVEVVKRVPSQVRGTALGGYaAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISAVLGII 383
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 67-306 2.08e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 46.42  E-value: 2.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  67 GAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSA 146
Cdd:cd17503   52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILL 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 147 GAVTGALIGSWLLQYD-----FRLVCGVGALLFVLCAGFNAwllpdwklstvrtplregmgRVLRDKRFVTYVLTLTGYY 221
Cdd:cd17503  132 APAIGPTLGGWLTDNLswrwiFYINLPIGILALLLAPLLDL--------------------RLFKDRNFTLGLLLSFLLG 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 222 MLAVQVMLMLPVMVNDIAGEPAAVKWMYAIEAVLSLTLLYPLARWSEKRFRLEQRLMAGLLVMTLSLVPVGLASNLQQLF 301
Cdd:cd17503  192 LGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLW 271


                 ....*
gi 742393757 302 SLICL 306
Cdd:cd17503  272 LIILP 276
MFS_BCD_PucC-like cd06176
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ...
 38-336 3.24e-05

Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 349950 [Multi-domain]  Cd Length: 409  Bit Score: 45.57  E-value: 3.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  38 VDNLGWAALMVGIALGLRQLVQQgLGIFGGAIADRLGAR-----PMIVTGMLLRAAGFATMAVA------HEPWVLWVSC 106
Cdd:cd06176   28 IVELGLPATLVGLLIALHYLVAP-LRVWIGHRSDTHPLRgyrrtPYIWLGMLLLALGLALAPFAalllagAAFWLGLALA 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 107 VLS----GLGGTLFDPPRSALVVKLVRPQERGRFFSLL-MMQDSAGAVTGALIGSWLLQYD-FRL--VCGVGALLFVLCA 178
Cdd:cd06176  107 VLAfllyGIGVGAAGTAFLALLADLTPEERRPRAVTVVwTMLILGIIVTAIVFGRLLDPYSpERLiqVFQIVALVALLLA 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 179 GFNAW----LLPDWKLSTVRTPlREGMGRVLRD-------KRFVTYVLTLT-GYYMlavQVMLM---------LPVmvnd 237
Cdd:cd06176  187 LLALWgverRRSRAALAAEEAP-PETFREALRLlwaspqaRRFFIFLFLSTlALFM---QDVILepfggevfgMSV---- 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 238 iaGEPAAVKWMYAIEAVLSLTLlypLARWSEKRFRLEQRLMAGLLVMTLSLVPVGLASNLQQ---LFSLICLFYIGSIIA 314
Cdd:cd06176  259 --GETTRLTAIWGGGTLLGMLL---AGFLLSRRLGKKRTAALGCLLSALGFLLLALAGLLGNpwlFRPGVFLLGLGNGLF 333

                        330       340
                 ....*....|....*....|..
gi 742393757 315 EPARETLSASLADARARGSYMG 336
Cdd:cd06176  334 TVGALTLMMDLTGEGTAGLFMG 355
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 10-180 3.62e-05

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 45.53  E-value: 3.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  10 LGKYFLLIDNMLVVLGFFVVFplisirFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAG 89
Cdd:COG2270  244 LLAYFFYRDGVQTVIAFAGIY------AAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVV 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  90 FATMAVAHEPWVLWVSCVLSGLG-GTLFDPPRSaLVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQY--DFRLv 166
Cdd:COG2270  318 CLAAYFLTTALAFWILGLLIGLVmGGIQALSRS-LLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLtgSQRL- 395

                        170
                 ....*....|....
gi 742393757 167 cGVGALLFVLCAGF 180
Cdd:COG2270  396 -GILSLIVFFVIGL 408
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 28-217 4.91e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 44.85  E-value: 4.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  28 VVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFggaiADRLGARPMIVTGMLLRAAGFATMAVAHEPWVLWVSCV 107
Cdd:cd17478   17 ALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYL----ADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 108 LSGLGGTLFDPPrSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQYDFRLV-CGVGALLFVLCAGFNAWLLP 186
Cdd:cd17478   93 LAGIGSAAFHPE-GARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGlLILLIIPGLAVALLLLRLRP 171

                        170       180       190
                 ....*....|....*....|....*....|.
gi 742393757 187 DWKLSTVRTPLREGMGRVLRDKRFVTYVLTL 217
Cdd:cd17478  172 LKKPEAKKAAAKSSARSTLKGVWRALLLLLI 202
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 63-189 1.06e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 43.85  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  63 GIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVrPQERGRFFSLLMM 142
Cdd:cd17333   48 SLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHG 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 742393757 143 QDSAGAVTGALIGSWLLQYDFRLVCGVGALLFVLCAGFNAWLLPDWK 189
Cdd:cd17333  127 FFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLFP 173
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 26-176 1.45e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 43.42  E-value: 1.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  26 FFVVFPLISIRFV---DNLGWAALMVGIALGLRQLVQqglgifgGAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWVL 102
Cdd:cd17312   22 FSVAKPPIVEEIGlskDDLGIIGSAFLIAYAVGKFIS-------GFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFF 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 742393757 103 WVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDS-AGAVTGALIGSWLLQYDFR---LVCGVGALLFVL 176
Cdd:cd17312   95 AVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNfGGILAPILAASLASYYGWRaafLVPGIVGLVVAI 172
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 64-161 2.39e-04

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 42.93  E-value: 2.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  64 IFGGAIADRLGARPMIVTGMLL-RAAGFATMAVAHEP-WVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLM 141
Cdd:cd17380   52 VLGGYLADRFGGKKVLLLAVALwSLATLLTPLLAYSSlPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVT 131

                         90       100
                 ....*....|....*....|
gi 742393757 142 MQDSAGAVTGALIGSWLLQY 161
Cdd:cd17380  132 AGSYLGTLLGGLIGPLLLEY 151
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 47-179 3.90e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 42.19  E-value: 3.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  47 MVGIALGlrqlvqqglGIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVK 126
Cdd:cd17365   44 LFGMAIG---------ALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSE 114

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 742393757 127 LVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQ-YDFR---LVCGVGALLFVLCAG 179
Cdd:cd17365  115 YAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPaFGWRsvfLLGGVPPLILLPLLR 171
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 20-112 4.00e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 42.21  E-value: 4.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  20 MLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEP 99
Cdd:cd17353   12 MHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISL 91

                         90
                 ....*....|....
gi 742393757 100 WVLW-VSCVLSGLG 112
Cdd:cd17353   92 PLLFlGYGVLGGIG 105
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 64-176 4.79e-04

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 41.84  E-value: 4.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  64 IFGGAIADRLGARPMIVTGMLlrAAGFATM-----AVAHEPWVLwVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFS 138
Cdd:cd17318   74 IPGGYLAEKYGAKRVLGYSIL--ITALLTLltplaARGGYGALI-VLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTS 150

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 742393757 139 LLMMQDSAGAVTGALIGSWLLQYD-----FRLVCGVGALLFVL 176
Cdd:cd17318  151 IAYSGSQFGTVIAMPLSGFLCESLgwpsiFYIFGGLGLLWCLL 193
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 15-307 9.70e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.00  E-value: 9.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  15 LLIDNMLVVLGFFVVFPLISIRFvDNLGWAALMVGIALGLrqlvqQGLGI-----FGGAIADRLGARPMIVTGMLLRAAG 89
Cdd:cd17477    1 LLLSVALLGLGSGLLLPLLSLRL-EREGVSTALIGLVASA-----YYLGIllgspLVPRLIRRVGHIRAFAAGAAITAVS 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  90 FATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQYDFRLVCGV 169
Cdd:cd17477   75 VLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 170 GALLFVlcagfnAWLLPDWKLSTVRTPLREGMGRVLRDKRFVTYVLTLTGYYMLAVQVML-MLPVMVNDIAGEPAAVKWM 248
Cdd:cd17477  155 AVLLLL------ALVPLLLTRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYsLLPLYGLRLGLSVAQAALL 228

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 742393757 249 YAIEAVLSLTLLYPLARWSEKRFRLEQRLMAGLLVMTLSLVPVGLASNLQQLFSLICLF 307
Cdd:cd17477  229 LAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLW 287
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 20-309 1.75e-03

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 40.09  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  20 MLVVLGFFVVFPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEP 99
Cdd:cd17314   12 SAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 100 WVLWVSC-VLSGLGGTLFdppRSALVVKLVR--PQERGRFFSLLMMQDSAGAVTGA-LIGSWLLQYDFRLVCGV-GALLF 174
Cdd:cd17314   92 FPLSYACfVFIGAGTGIL---YGSAVLVTTQyfPDTKGLALGLPTTGYSLGLVLGSpLLRILWVFYGLALVYTIlGILAA 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 175 --VLCAGFNAWLLPdwKLSTVRTPLREG----MGRVLRDKRF----VTYVLTLTGYYMLavqVMLMLPVMVNDIAGEPAA 244
Cdd:cd17314  169 ivLSVVSLLGFKEP--PDNQARLHVQKKktqtMGEIFRDKVFwilfIAIFLVLIGGFLF---IANMASLVRSLQLDAPSF 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 742393757 245 VKWMYAIEAVLSlTLLYPLARWSEKRFRLEQRLMA---GLLVMTLSLVPVGLASNLQQLFSLICLFYI 309
Cdd:cd17314  244 VTKLMSIYGLFN-AFGRLLWGIVADFFGGRLSTLSillTILGLGLCAFLFLLKMTPVGLVLTGSLLGF 310
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 24-297 1.94e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 39.87  E-value: 1.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  24 LGFFVVFPLISIRFVDnLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVtGMLLRAAGFATMAVAHEPWVLW 103
Cdd:cd17335   11 AALGSLLPFLSVYLKQ-LGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALL-LLSLLAAVLFFLSLFFVAQIFW 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 104 VSCVLSGLGGTLFDPPRS---ALVVKLVRpqERGRFFSLLMMQDSAG-----AVTGALIGSWLLQYDFRLVCGVGALlFV 175
Cdd:cd17335   89 LLLLLVILGAFFSAPVVPlvdSITLQYLG--EERERYGKQRLWGSIGfgiaaLLVGILIDRSSTYKNYTIAFYVFAV-LM 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 176 LCAGFNAWLLPDWKLSTVRTPLREGMGRVLRDKRFVTYVLT--LTGYYMLAVQVMLMLpvMVNDIAGEPAAVKWMYAIEA 253
Cdd:cd17335  166 LLALLLALKFPFRPKHPEPNENTGGLLALLRNPRVLAFLLVafLMGFGHGLIYSFLFW--HLQDLGGSKTLIGLLWTVGV 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 742393757 254 VLSLTLLYPLARWSeKRFRLEQRLMAGLLVMTLSLVPVGLASNL 297
Cdd:cd17335  244 VSEIPFFFFSSRLI-QRFGHVGLLYLGLLAYVVRWLLYSFLENP 286
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 20-134 2.71e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 39.48  E-value: 2.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  20 MLVVLGFFVVFPLISIRFVDN----LGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGFATMAV 95
Cdd:cd17504  187 LLAGFGMFMVFQLLPQLLQLPtptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLAL 266

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 742393757  96 AH-EPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERG 134
Cdd:cd17504  267 LHsSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTG 306
PRK12382 PRK12382
putative transporter; Provisional
 22-206 3.19e-03

putative transporter; Provisional


Pssm-ID: 183487 [Multi-domain]  Cd Length: 392  Bit Score: 39.27  E-value: 3.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  22 VVLGFFVV---FPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRA-AGFATMAVAH 97
Cdd:PRK12382  24 VFLTYMTVglpLPVIPLFVHHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKRSALQGMLACGlAGLAYLLAAI 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  98 EPWVLWVSCVLSGLGGTLFDPPRSALVV-------KLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLL-QYDFRLVCGV 169
Cdd:PRK12382 104 LPVSAPFKFALLVVGRLILGFGESQLLTgaltwglGLVGPKHSGKVMSWNGMAMYGALAAGAPLGLLLHsHFGFAALALT 183

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 742393757 170 GALLFVLCAGFNAWLLPDWKLSTVRTPLREGMGRVLR 206
Cdd:PRK12382 184 TMVLPLLAWAFNGTVRKVPAHAGERPSLWSVVGLIWK 220
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 21-314 3.69e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 39.07  E-value: 3.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  21 LVVLGFFVV----------FPLISIRFVDNLGWAALMVGIALGLRQLVQQGLGIFGGAIADRLGARPMIVTGMLLRAAGF 90
Cdd:cd17352    3 VVVFASFLVnfftdgilnsFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  91 ATMAVAHEPWVLWVS-CVLSGLGGTLFDPPRSALVVKLVRpQERGRFFSLLMMQDSAGAVTGALIGSWLL-----QYDFR 164
Cdd:cd17352   83 LLSSFATSLWQLYLTyGVLGGLGLGLIYSPAIVIVGQYFE-KKRGLATGIAVAGSGVGTFVFPPLLRYLLdnygwRGALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757 165 LVCGVGALLFVLCAgfnawllpdwklstvrtplregMGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPVMVNDIAGEPAA 244
Cdd:cd17352  162 ILGGLCLNLCVCGL----------------------LLRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESD 219

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 742393757 245 VKWMYAIEAVLSLT---LLYPLARWseKRFRLEQRLMAGLLVMTLSLVPVGLASNLQQL--FSLICLFYIGSIIA 314
Cdd:cd17352  220 AAFLLSIIGISDIVgriLLGLLADK--PRIGRLYLYIFTLLILGLSLLAFPLATTYVGLivFSVLFGFCSGSYSS 292
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 63-112 6.55e-03

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 38.41  E-value: 6.55e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 742393757  63 GIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWVLWVSCVLSGLG 112
Cdd:cd17360   52 AAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLG 101
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 14-180 6.90e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 38.30  E-value: 6.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  14 FLLIDNMLVVLGFFVVFPLISIRFVDnLGW----AALMVGIaLGLRQLVQQglgIFGGAIADRLGARPMIVTGMLLRAAG 89
Cdd:cd17352  187 LLALGVSFAMLGFFVPFVYLPSYAKS-LGIdesdAAFLLSI-IGISDIVGR---ILLGLLADKPRIGRLYLYIFTLLILG 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  90 FATMAV--AHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLLMMQDSAGAVTGALIGSWLLQY--DFRL 165
Cdd:cd17352  262 LSLLAFplATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYtgDYDA 341

                        170
                 ....*....|....*
gi 742393757 166 VCGVGALLFVLCAGF 180
Cdd:cd17352  342 AFYFCGACLLLSGVL 356
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 63-161 9.13e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 38.05  E-value: 9.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  63 GIFGGAIADRLGARPMIVTGMLLRAAGFATMAVAHEPWVLWVSCVLSGLG-GTLFdPPRSALVVKLVRPQERGRFFSLLM 141
Cdd:cd17371   51 GILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGfGGEW-AAGAALMAEYVPARHRGKALGYVQ 129

                         90       100
                 ....*....|....*....|
gi 742393757 142 MQDSAGAVTGALIGSWLLQY 161
Cdd:cd17371  130 SGWAVGWLLATLLAALLFPL 149
PRK05122 PRK05122
major facilitator superfamily transporter; Provisional
 65-184 9.72e-03

major facilitator superfamily transporter; Provisional


Pssm-ID: 235348 [Multi-domain]  Cd Length: 399  Bit Score: 37.94  E-value: 9.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742393757  65 FGGAIaDRLGARPMIVTGMLLRAAGFATMAVAHEPWVLWVSCVLSGLGGTLFDPPRSALVVKLVRPQERGRFFSLL-MMQ 143
Cdd:PRK05122 269 FGNLI-NRLGGLRVAIVSLLVEILGLLLLWLAPSPWMALIGAALTGFGFSLVFPALGVEAVKRVPPQNRGAALGAYsVFL 347

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 742393757 144 DSAGAVTGALIGSWLLQYDFRLVCGVGALLFVLCAGFNAWL 184
Cdd:PRK05122 348 DLSLGITGPLAGLVASWFGYPSIFLAAALAALLGLALTWLL 388
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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