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Conserved domains on  [gi|742394766|ref|WP_038873891|]
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MULTISPECIES: DeoR/GlpR family DNA-binding transcription regulator [Serratia]

Protein Classification

DeoR/GlpR family DNA-binding transcription regulator( domain architecture ID 11442564)

DeoR/GlpR family DNA-binding transcription regulator is a helix-turn-helix type transcriptional regulator that may be involved in sugar metabolism

Gene Ontology:  GO:0003700|GO:0003677
PubMed:  15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-251 4.60e-84

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


:

Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 251.21  E-value: 4.60e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766   1 MLTSQRKKIILEKLAEDGQVLAKQLSEMFGLSEDTVRRDLRELDAEGLLQRVHGGALPVSSAIA--SFAERNQLESGAKR 78
Cdd:COG1349    1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAepPFAERETLNAEEKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766  79 AIAKAAAALIAPGQVVIIDGGTTSAELVRQLPLNLNATIVTHSPSVAVGLVDHPTVEVILIGGRLYKHSIVSVGAAAVEA 158
Cdd:COG1349   81 AIARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766 159 MSHIRADIYFMGVTGVHPTAGLSTGDLEEAYIKRALAARAAETVVLASAAKLNAASQYAIGDITLAHTIIVERATDDALI 238
Cdd:COG1349  161 LRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELL 240

                        250
                 ....*....|...
gi 742394766 239 APLQQAGVSVLKA 251
Cdd:COG1349  241 EALEEAGVEVIVA 253
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-251 4.60e-84

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 251.21  E-value: 4.60e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766   1 MLTSQRKKIILEKLAEDGQVLAKQLSEMFGLSEDTVRRDLRELDAEGLLQRVHGGALPVSSAIA--SFAERNQLESGAKR 78
Cdd:COG1349    1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAepPFAERETLNAEEKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766  79 AIAKAAAALIAPGQVVIIDGGTTSAELVRQLPLNLNATIVTHSPSVAVGLVDHPTVEVILIGGRLYKHSIVSVGAAAVEA 158
Cdd:COG1349   81 AIARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766 159 MSHIRADIYFMGVTGVHPTAGLSTGDLEEAYIKRALAARAAETVVLASAAKLNAASQYAIGDITLAHTIIVERATDDALI 238
Cdd:COG1349  161 LRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELL 240

                        250
                 ....*....|...
gi 742394766 239 APLQQAGVSVLKA 251
Cdd:COG1349  241 EALEEAGVEVIVA 253
TranRegGlpR_Halo NF041397
HTH-type transcriptional regulator GlpR;
1-249 1.09e-42

HTH-type transcriptional regulator GlpR;


Pssm-ID: 469288 [Multi-domain]  Cd Length: 253  Bit Score: 145.44  E-value: 1.09e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766   1 MLTSQRKKIILEKLAEDGQVLAKQLSEMFGLSEDTVRRDLRELDAEGLLQRVHGGALPVSSAIA--SFAER--NQLESga 76
Cdd:NF041397   1 MLPEERKRKIVELVTERDGCSVEELADELDVSKATIRRDLRDLEDRGLIERSHGGAVPVTSVGRerSYGQRevQNLEA-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766  77 KRAIAKAAAALIAPGQVVIIDGGTTSAELVRQLPLNLNATIVTHSPSVAVGLVDHpTVEVILIGGRLYKHSIVSVGAAAV 156
Cdd:NF041397  79 KRAIAERAVEEIHDGQVVFFDAGTTTMEVAKRVPTDGSFLAVTNSPLLALELAER-DGEVKLTGGTLRPRTRALVGPTAE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766 157 EAMSHIRADIYFMGVTGVHPTAGLSTGDLEEAYIKRALAARAAETVVLASAAKLNAASQYAIGDITLAHTIIVERATDDA 236
Cdd:NF041397 158 SFMERTNFDLLFLGTNGIDPDGGLTTPNEDEARMKELMVENAKRVVLVADGSKFGERSFVRFADLDDVDLFVTDGALPEE 237

                        250
                 ....*....|...
gi 742394766 237 LIAPLQQAGVSVL 249
Cdd:NF041397 238 LREAFEEAGVEVV 250
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 83-231 2.22e-38

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 131.48  E-value: 2.22e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766   83 AAAALIAPGQVVIIDGGTTSAELVRQLPLNLNATIVTHSPSVAVGLVDHPTVEVILIGGRLYKHSIVSVGAAAVEAMSHI 162
Cdd:pfam00455  12 AAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFVGPLAEEFLRQF 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 742394766  163 RADIYFMGVTGVHPTAGLSTGDLEEAYIKRALAARAAETVVLASAAKLNAASQYAIGDITLAHTIIVER 231
Cdd:pfam00455  92 NVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
PRK09802 PRK09802
DeoR family transcriptional regulator;
3-249 4.19e-36

DeoR family transcriptional regulator;


Pssm-ID: 182086 [Multi-domain]  Cd Length: 269  Bit Score: 128.82  E-value: 4.19e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766   3 TSQRKKIILEKLAEDGQVLAKQLSEMFGLSEDTVRRDLRELDAEGLLQRVHGGALPVSSAIA----SFAERNQLESGAKR 78
Cdd:PRK09802  15 TSERREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALICDSTTPsvepSVEDKSALNTAMKR 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766  79 AIAKAAAALIAPGQVVIIDGGTTSAELVRQLPLNLNATIVTHSPSVAVGLVDHPTVEVILIGGRLYKHSIVSVGAAAVEA 158
Cdd:PRK09802  95 SVAKAAVELIQPGHRVILDSGTTTFEIARLMRKHTDVIAMTNGMNVANALLEAEGVELLMTGGHLRRQSQSFYGDQAEQS 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766 159 MSHIRADIYFMGVTGVHPTAGLSTGDLEEAYIKRALAARAAETVVLASAAKLNAASQYAIGDITLAHTIIVERATDDALI 238
Cdd:PRK09802 175 LQNYHFDMLFLGVDAIDLERGVSTHNEDEARLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEGIPADSL 254

                        250
                 ....*....|.
gi 742394766 239 APLQQAGVSVL 249
Cdd:PRK09802 255 EGLRKAGVEVI 265
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
6-56 1.87e-12

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 60.31  E-value: 1.87e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 742394766     6 RKKIILEKLAEDGQVLAKQLSEMFGLSEDTVRRDLRELDAEGLLQRVHGGA 56
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGA 51
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 24-54 3.11e-04

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 38.20  E-value: 3.11e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 742394766  24 QLSEMFGLSEDTVRRDLRELDAEGLLQRVHG 54
Cdd:cd07377   30 ELAEELGVSRTTVREALRELEAEGLVERRPG 60
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 4-60 2.36e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 38.11  E-value: 2.36e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 742394766    4 SQRKKIILEKLAEDGQVLAKQLSEMFGLSEDTVRRDLRELDAEGLLQRVHGGALPVS 60
Cdd:TIGR01884 142 SREELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQKGRKGKRYS 198
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-251 4.60e-84

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 251.21  E-value: 4.60e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766   1 MLTSQRKKIILEKLAEDGQVLAKQLSEMFGLSEDTVRRDLRELDAEGLLQRVHGGALPVSSAIA--SFAERNQLESGAKR 78
Cdd:COG1349    1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAepPFAERETLNAEEKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766  79 AIAKAAAALIAPGQVVIIDGGTTSAELVRQLPLNLNATIVTHSPSVAVGLVDHPTVEVILIGGRLYKHSIVSVGAAAVEA 158
Cdd:COG1349   81 AIARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766 159 MSHIRADIYFMGVTGVHPTAGLSTGDLEEAYIKRALAARAAETVVLASAAKLNAASQYAIGDITLAHTIIVERATDDALI 238
Cdd:COG1349  161 LRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELL 240

                        250
                 ....*....|...
gi 742394766 239 APLQQAGVSVLKA 251
Cdd:COG1349  241 EALEEAGVEVIVA 253
TranRegGlpR_Halo NF041397
HTH-type transcriptional regulator GlpR;
1-249 1.09e-42

HTH-type transcriptional regulator GlpR;


Pssm-ID: 469288 [Multi-domain]  Cd Length: 253  Bit Score: 145.44  E-value: 1.09e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766   1 MLTSQRKKIILEKLAEDGQVLAKQLSEMFGLSEDTVRRDLRELDAEGLLQRVHGGALPVSSAIA--SFAER--NQLESga 76
Cdd:NF041397   1 MLPEERKRKIVELVTERDGCSVEELADELDVSKATIRRDLRDLEDRGLIERSHGGAVPVTSVGRerSYGQRevQNLEA-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766  77 KRAIAKAAAALIAPGQVVIIDGGTTSAELVRQLPLNLNATIVTHSPSVAVGLVDHpTVEVILIGGRLYKHSIVSVGAAAV 156
Cdd:NF041397  79 KRAIAERAVEEIHDGQVVFFDAGTTTMEVAKRVPTDGSFLAVTNSPLLALELAER-DGEVKLTGGTLRPRTRALVGPTAE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766 157 EAMSHIRADIYFMGVTGVHPTAGLSTGDLEEAYIKRALAARAAETVVLASAAKLNAASQYAIGDITLAHTIIVERATDDA 236
Cdd:NF041397 158 SFMERTNFDLLFLGTNGIDPDGGLTTPNEDEARMKELMVENAKRVVLVADGSKFGERSFVRFADLDDVDLFVTDGALPEE 237

                        250
                 ....*....|...
gi 742394766 237 LIAPLQQAGVSVL 249
Cdd:NF041397 238 LREAFEEAGVEVV 250
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 83-231 2.22e-38

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 131.48  E-value: 2.22e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766   83 AAAALIAPGQVVIIDGGTTSAELVRQLPLNLNATIVTHSPSVAVGLVDHPTVEVILIGGRLYKHSIVSVGAAAVEAMSHI 162
Cdd:pfam00455  12 AAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFVGPLAEEFLRQF 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 742394766  163 RADIYFMGVTGVHPTAGLSTGDLEEAYIKRALAARAAETVVLASAAKLNAASQYAIGDITLAHTIIVER 231
Cdd:pfam00455  92 NVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
PRK09802 PRK09802
DeoR family transcriptional regulator;
3-249 4.19e-36

DeoR family transcriptional regulator;


Pssm-ID: 182086 [Multi-domain]  Cd Length: 269  Bit Score: 128.82  E-value: 4.19e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766   3 TSQRKKIILEKLAEDGQVLAKQLSEMFGLSEDTVRRDLRELDAEGLLQRVHGGALPVSSAIA----SFAERNQLESGAKR 78
Cdd:PRK09802  15 TSERREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALICDSTTPsvepSVEDKSALNTAMKR 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766  79 AIAKAAAALIAPGQVVIIDGGTTSAELVRQLPLNLNATIVTHSPSVAVGLVDHPTVEVILIGGRLYKHSIVSVGAAAVEA 158
Cdd:PRK09802  95 SVAKAAVELIQPGHRVILDSGTTTFEIARLMRKHTDVIAMTNGMNVANALLEAEGVELLMTGGHLRRQSQSFYGDQAEQS 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766 159 MSHIRADIYFMGVTGVHPTAGLSTGDLEEAYIKRALAARAAETVVLASAAKLNAASQYAIGDITLAHTIIVERATDDALI 238
Cdd:PRK09802 175 LQNYHFDMLFLGVDAIDLERGVSTHNEDEARLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEGIPADSL 254

                        250
                 ....*....|.
gi 742394766 239 APLQQAGVSVL 249
Cdd:PRK09802 255 EGLRKAGVEVI 265
PRK10906 PRK10906
DeoR/GlpR family transcriptional regulator;
1-223 4.16e-21

DeoR/GlpR family transcriptional regulator;


Pssm-ID: 182827 [Multi-domain]  Cd Length: 252  Bit Score: 88.76  E-value: 4.16e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766   1 MLTSQRKKIILEKLAEDGQVLAKQLSEMFGLSEDTVRRDLRELDAEGLLQRVHGGA-LPVSSAIASFAERNQLESGAKRA 79
Cdd:PRK10906   1 MKQTQRHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGAaLPSSSVNTPWHDRKATQTEEKER 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766  80 IAKAAAALIAPGQVVIIDGGTTSAELVRQLPLNLNATIVTHSPSVAVGLVDHPTVEVILIGGRLYKHSIVSVGAAAVEAM 159
Cdd:PRK10906  81 IARKVASQIPNGATLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMAKEDFRIILAGGELRSRDGGIIGEATLDFI 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 742394766 160 SHIRADIYFMGVTGVHPTAGLSTGDLEEAYIKRALAARAAETVVLASAAKLNAASQYAIGDITL 223
Cdd:PRK10906 161 SQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISM 224
srlR PRK10434
DNA-binding transcriptional repressor;
1-249 7.29e-21

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 88.21  E-value: 7.29e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766   1 MLTSQRKKIILEKLAEDGQVLAKQLSEMFGLSEDTVRRDLRELDAEGLLQRVHGGAlpVSSAIAS---FAERNQLESGAK 77
Cdd:PRK10434   1 MKPRQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGV--VLNKEESdppIDHKTLINTHKK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766  78 RAIAKAAAALIAPGQVVIIDGGTTSAELVRQLPLNLNATIVTHSPSVAVGLVDHPTVEVILI-GGRLYKHSIVSVGAAAV 156
Cdd:PRK10434  79 ELIAEAAVSLIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDNEQTILMpGGTFRKKSASFHGQLAE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766 157 EAMSHIRADIYFMGVTGVHPTAGLSTgdLEEAY-IKRALAARAAETVVLASAAKLNAASQYAIGDITLAHTIIVERATDD 235
Cdd:PRK10434 159 NAFEHFTFDKLFIGTDGIDLNAGVTT--FNEVYtVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGIDP 236

                        250
                 ....*....|....
gi 742394766 236 ALIAPLQQAGVSVL 249
Cdd:PRK10434 237 AFRQALEEKGIEVI 250
PRK10411 PRK10411
L-fucose operon activator;
2-228 4.65e-16

L-fucose operon activator;


Pssm-ID: 236684 [Multi-domain]  Cd Length: 240  Bit Score: 74.84  E-value: 4.65e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766   2 LTSQRKKIILEKLAEDGQVLAKQLSEMFGLSEDTVRRDLRELDAEGLLQRVHGGALPVSSAIAS----FAERNQLESGAK 77
Cdd:PRK10411   1 MKAARQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRAKYIHRQNQDsgdpFHIRLKSHYAHK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766  78 RAIAKAAAALIAPGQVVIIDGGTTSAELVRQLPlNLNATIVTHSPSVAVGLVDHPTVEVILIGGRLYKHSIVSVGAAAVE 157
Cdd:PRK10411  81 ADIAREALAWIEEGMVIALDASSTCWYLARQLP-DINIQVFTNSHPICQELGKRERIQLISSGGTLERKYGCYVNPSLIS 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 742394766 158 AMSHIRADIYFMGVTGVHPTAGLSTGDLEEAYIKRALAARAAETVVLASAAKLNAASQYAIGDITLAHTII 228
Cdd:PRK10411 160 QLKSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHII 230
PRK13509 PRK13509
HTH-type transcriptional regulator UlaR;
1-251 1.34e-15

HTH-type transcriptional regulator UlaR;


Pssm-ID: 184100 [Multi-domain]  Cd Length: 251  Bit Score: 73.89  E-value: 1.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766   1 MLTSQRKKIILEKLAEDGQVLAKQLSEMFGLSEDTVRRDLRELDAEGLLQRVHGGA--LPVSSAIASFAERNQLES-GAK 77
Cdd:PRK13509   1 MTEAQRHQILLELLAQLGFVTVEKVIERLGISPATARRDINKLDESGKLKKVRNGAeaITQQRPRWTPMNIHQAQNhDEK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766  78 RAIAKAAAALIAPGQVVIIDGGTTSAELVRQLpLNLNATIVTHSPSVAVGLVDHPTVEVILIGGRLYKHSIVSVgAAAVE 157
Cdd:PRK13509  81 VRIAKAASQLCNPGESVVINCGSTAFLLGREL-CGKPVQIITNYLPLANYLIDQEHDSVIIMGGQYNKSQSITL-SPQGS 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766 158 AMSHIRADIYFMGVTGVhPTAGLSTGDLEEAYIKRALAARAAETVVLASAAKLNAASQYAIGDITLAHTIIVERATDDAL 237
Cdd:PRK13509 159 ENSLYAGHWMFTSGKGL-TADGLYKTDMLTAMAEQKMLSVVGKLVVLVDSSKIGERAGMLFSRADQIDMLITGKNADPEV 237

                        250
                 ....*....|....
gi 742394766 238 IAPLQQAGVSVLKA 251
Cdd:PRK13509 238 LQQLEAQGVSILLV 251
PRK10681 PRK10681
DNA-binding transcriptional repressor DeoR; Provisional
 23-249 1.57e-13

DNA-binding transcriptional repressor DeoR; Provisional


Pssm-ID: 182644 [Multi-domain]  Cd Length: 252  Bit Score: 68.18  E-value: 1.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766  23 KQLSEMFGLSEDTVRRDLRELDAEGLLQrvhGGAL-----PVSSAIASFAERNQLESgaKRAIAKAAAALIAPGQVVIID 97
Cdd:PRK10681  25 KDAAALLGVSEMTIRRDLNAHSAPVVLL---GGYIvleprSASHYLLSDQKSRLVEE--KRRAAQLAATLVEPNQTLFFD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394766  98 GGTTSAELVRQLPLNLNATIVTHSPSVAVGLVDHPTVEVILIGGRLYKHSIVSVGAAAVEAMSHIRADIYFMGVTGVHPT 177
Cdd:PRK10681 100 CGTTTPWIIEAIDNELPFTAVCYSLNTFLALQEKPHCRAILCGGEFHASNAIFKPLDFQQTLDNICPDIAFYSAAGVHVS 179

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 742394766 178 AGLSTGDLEEAYIKRALAARAAETVVLASAAKLNAASQYAIGDITLAHTIIVERATDDALIAPLQQAGVSVL 249
Cdd:PRK10681 180 KGATCFNLEELPVKHWAMAMAQKHVLVVDHSKFGKVRPARMGDLTRFDTVVSDRCPDDEFVKYAQAQRIKLM 251
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
6-56 1.87e-12

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 60.31  E-value: 1.87e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 742394766     6 RKKIILEKLAEDGQVLAKQLSEMFGLSEDTVRRDLRELDAEGLLQRVHGGA 56
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGA 51
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
6-61 5.76e-12

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 59.20  E-value: 5.76e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 742394766    6 RKKIILEKLAEDGQVLAKQLSEMFGLSEDTVRRDLRELDAEGLLQRVHGGALPVSS 61
Cdd:pfam08220   1 RIQQILELLKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHGGAVSNSS 56
COG3177 COG3177
Fic family protein [Transcription];
4-55 1.48e-05

Fic family protein [Transcription];


Pssm-ID: 442410 [Multi-domain]  Cd Length: 316  Bit Score: 45.45  E-value: 1.48e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 742394766   4 SQRKKIILEKLAEDGQVLAKQLSEMFGLSEDTVRRDLRELDAEGLLQRVHGG 55
Cdd:COG3177  260 NERQRKLLELLFENPVLTASELAELLGVSRRTARRDLKDLVELGILEKVGGG 311
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
24-54 2.26e-04

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 41.39  E-value: 2.26e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 742394766  24 QLSEMFGLSEDTVRRDLRELDAEGLLQRVHG 54
Cdd:COG2188   34 ELAEEFGVSRMTVRKALDELVEEGLLERRQG 64
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 24-54 3.11e-04

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 38.20  E-value: 3.11e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 742394766  24 QLSEMFGLSEDTVRRDLRELDAEGLLQRVHG 54
Cdd:cd07377   30 ELAEELGVSRTTVREALRELEAEGLVERRPG 60
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
23-56 7.06e-04

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 36.78  E-value: 7.06e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 742394766    23 KQLSEMFGLSEDTVRRDLRELDAEGLLQRVHGGA 56
Cdd:smart00345  24 RELAAQLGVSRTTVREALSRLEAEGLVQRRPGSG 57
CasRa_I-A cd09655
CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly ...
 4-60 9.18e-04

CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Predicted transcriptional regulator of CRISPR/Cas system


Pssm-ID: 187786 [Multi-domain]  Cd Length: 198  Bit Score: 39.28  E-value: 9.18e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 742394766   4 SQRKKIILEKLAEDGQVLAKQLSEMFGLSEDTVRRDLRELDAEGLLQRVHGGALPVS 60
Cdd:cd09655  138 SREELKILEVLKAKGEKSVKNIAKKLGKSLSTISRHLRELEKKGLVEQKGTKGKRYS 194
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 23-56 1.29e-03

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 36.44  E-value: 1.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 742394766   23 KQLSEMFGLSEDTVRRDLRELDAEGLLQRVHGGA 56
Cdd:pfam00392  28 RELAAEFGVSRTTVREALRRLEAEGLVERRQGRG 61
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 4-60 2.36e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 38.11  E-value: 2.36e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 742394766    4 SQRKKIILEKLAEDGQVLAKQLSEMFGLSEDTVRRDLRELDAEGLLQRVHGGALPVS 60
Cdd:TIGR01884 142 SREELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQKGRKGKRYS 198
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 7-48 7.45e-03

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 33.95  E-value: 7.45e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 742394766    7 KKIILEKLAEDGQVLAKQLSEMFGLSEDTVRRDLRELDAEGL 48
Cdd:pfam08279   1 LQILQLLLEARGPISGQELAEKLGVSRRTIRRDIKILEELGV 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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