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Conserved domains on  [gi|742400311|ref|WP_038879436|]
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MULTISPECIES: GntR family transcriptional regulator [Serratia]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
19-242 2.69e-61

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 192.38  E-value: 2.69e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742400311  19 PRYIQLATAIETAIRQQVLAAEAFLPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRVA-MRIGYSLDKDSGF 97
Cdd:COG2188    5 PLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAePKIEYPLSRLTSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742400311  98 TAQALRHGSSVSNRWLLRTRVGAPAKAAAALGLAEGDEVIKLRRLRLLNGSPVSLETTYIPPRFLPEPGQLE---HSLYA 174
Cdd:COG2188   85 TEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDletGSLYE 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 742400311 175 LWQSR-GIVPEDKHFLLKAVSCSDEVAELLNVPCGAPLLHITQTSRNAQGEALEFSDILCRSDVYEFEV 242
Cdd:COG2188  165 LLEERyGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVV 233
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
19-242 2.69e-61

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 192.38  E-value: 2.69e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742400311  19 PRYIQLATAIETAIRQQVLAAEAFLPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRVA-MRIGYSLDKDSGF 97
Cdd:COG2188    5 PLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAePKIEYPLSRLTSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742400311  98 TAQALRHGSSVSNRWLLRTRVGAPAKAAAALGLAEGDEVIKLRRLRLLNGSPVSLETTYIPPRFLPEPGQLE---HSLYA 174
Cdd:COG2188   85 TEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDletGSLYE 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 742400311 175 LWQSR-GIVPEDKHFLLKAVSCSDEVAELLNVPCGAPLLHITQTSRNAQGEALEFSDILCRSDVYEFEV 242
Cdd:COG2188  165 LLEERyGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVV 233
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 103-239 5.71e-26

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 98.52  E-value: 5.71e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742400311   103 RHGSSVSNRWLLRTRVGAPAKAAAALGLAEGDEVIKLRRLRLLNGSPVSLETTYIPPRFLPEPGQ--LEHSLYALWQSR- 179
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEedLSGSLYEYLEERl 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 742400311   180 ---GIVPEDKHFLLKAVSCSDEVAELLNVPCGAPLLHITQTSRNAQGEALEFSDILCRSDVYE 239
Cdd:smart00866  81 glkIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 105-239 1.61e-25

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 97.28  E-value: 1.61e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742400311  105 GSSVSNRWLLRTRVGAPAKAAAALGLAEGDEVIKLRRLRLLNGSPVSLETTYIPPRFLPEPGQ---LEHSLYALWQSR-G 180
Cdd:pfam07702   3 GREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEedlEEGSLYDYLEERyG 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 742400311  181 IVPEDKHFLLKAVSCSDEVAELLNVPCGAPLLHITQTSRNAQGEALEFSDILCRSDVYE 239
Cdd:pfam07702  83 LPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 20-240 9.45e-23

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 92.92  E-value: 9.45e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742400311  20 RYIQLATAIETAIRQQVLAAEaFLPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRVAMR-IGYSLDKDSGFT 98
Cdd:PRK10079  13 RYQEIAAKLEQELRQHYRCGD-YLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRpYDYPLNAQARFS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742400311  99 AQALRHGSSVSNRWLLRTRVGAPAKAAAALGLAEGDEVIKLRRLRLLNGSPVSLETTYIPP-RFLPEPGQLEH-SLYA-L 175
Cdd:PRK10079  92 QNLLDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYFADlTWWPTLQRFDSgSLHDfL 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 742400311 176 WQSRGIVPEDKHFLLKAVSCSDEVAELLNVPCGAPLLHI-TQTSRNAQGEALEFSDILCRSDVYEF 240
Cdd:PRK10079 172 REQLGIALRRSQTRISARRAQAKESQLLEIPNMSPLLCVrTLNHRDGESSPAEYSVSLTRADMIEF 237
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 19-84 1.36e-18

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 76.72  E-value: 1.36e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 742400311  19 PRYIQLATAIETAIRQQVLAAEAFLPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRVA 84
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
19-242 2.69e-61

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 192.38  E-value: 2.69e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742400311  19 PRYIQLATAIETAIRQQVLAAEAFLPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRVA-MRIGYSLDKDSGF 97
Cdd:COG2188    5 PLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAePKIEYPLSRLTSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742400311  98 TAQALRHGSSVSNRWLLRTRVGAPAKAAAALGLAEGDEVIKLRRLRLLNGSPVSLETTYIPPRFLPEPGQLE---HSLYA 174
Cdd:COG2188   85 TEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDletGSLYE 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 742400311 175 LWQSR-GIVPEDKHFLLKAVSCSDEVAELLNVPCGAPLLHITQTSRNAQGEALEFSDILCRSDVYEFEV 242
Cdd:COG2188  165 LLEERyGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVV 233
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 103-239 5.71e-26

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 98.52  E-value: 5.71e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742400311   103 RHGSSVSNRWLLRTRVGAPAKAAAALGLAEGDEVIKLRRLRLLNGSPVSLETTYIPPRFLPEPGQ--LEHSLYALWQSR- 179
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEedLSGSLYEYLEERl 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 742400311   180 ---GIVPEDKHFLLKAVSCSDEVAELLNVPCGAPLLHITQTSRNAQGEALEFSDILCRSDVYE 239
Cdd:smart00866  81 glkIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 105-239 1.61e-25

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 97.28  E-value: 1.61e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742400311  105 GSSVSNRWLLRTRVGAPAKAAAALGLAEGDEVIKLRRLRLLNGSPVSLETTYIPPRFLPEPGQ---LEHSLYALWQSR-G 180
Cdd:pfam07702   3 GREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEedlEEGSLYDYLEERyG 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 742400311  181 IVPEDKHFLLKAVSCSDEVAELLNVPCGAPLLHITQTSRNAQGEALEFSDILCRSDVYE 239
Cdd:pfam07702  83 LPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 20-240 9.45e-23

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 92.92  E-value: 9.45e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742400311  20 RYIQLATAIETAIRQQVLAAEaFLPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRVAMR-IGYSLDKDSGFT 98
Cdd:PRK10079  13 RYQEIAAKLEQELRQHYRCGD-YLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRpYDYPLNAQARFS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742400311  99 AQALRHGSSVSNRWLLRTRVGAPAKAAAALGLAEGDEVIKLRRLRLLNGSPVSLETTYIPP-RFLPEPGQLEH-SLYA-L 175
Cdd:PRK10079  92 QNLLDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYFADlTWWPTLQRFDSgSLHDfL 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 742400311 176 WQSRGIVPEDKHFLLKAVSCSDEVAELLNVPCGAPLLHI-TQTSRNAQGEALEFSDILCRSDVYEF 240
Cdd:PRK10079 172 REQLGIALRRSQTRISARRAQAKESQLLEIPNMSPLLCVrTLNHRDGESSPAEYSVSLTRADMIEF 237
PRK11402 PRK11402
transcriptional regulator PhoB;
12-243 8.03e-22

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 90.28  E-value: 8.03e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742400311  12 LAQGAVAPRYIQLATAIETAIRQQVLAAEAFLPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRV-AMRIGYS 90
Cdd:PRK11402   2 TDRYSHQLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVqSQKVENA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742400311  91 LDKDSGFTAQALRHGSSVSNRWLLRTRVGAPAKAAAALGLAEgDEVIKLRRLRLLNGSPVSLETTYIPPRFLPEPGQLEH 170
Cdd:PRK11402  82 LLTVSGFTDFGVSQGKATKEKVIEQERVSAAPFCEKLNIPGN-SEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYV 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 742400311 171 ---SLYALWQSR-GIVPEDKHFLLKAVSCSDEVAELLNVPCGAPLLHITQTSRNAQGEALEFSDILCRSDVYEFEVN 243
Cdd:PRK11402 161 egsSTYQLFQERfDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTLTID 237
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 19-84 1.36e-18

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 76.72  E-value: 1.36e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 742400311  19 PRYIQLATAIETAIRQQVLAAEAFLPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRVA 84
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK09764 PRK09764
GntR family transcriptional regulator;
19-240 3.25e-17

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 77.95  E-value: 3.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742400311  19 PRYIQLATAIETAIRQQVLAAEAFLPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRVAM-RIGYSLDKDSGF 97
Cdd:PRK09764   5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEeRVNYDIFQLTSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742400311  98 TAQ-ALRHGSSVSNRwLLRTRVGAPAKAAAALGLAEGDEVIKLRRLRLLNGSPVSLETTYIPPRFLPEPGQ--LEHSLYA 174
Cdd:PRK09764  85 DEKlSDRHVDTHSEV-LIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWqvMENSKYH 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 742400311 175 -LWQSRGIVPEDKHFLLKAVSCSDEVAELLNVPCGAPLLHITQTSRNAQGEALEFSDILCRSDVYEF 240
Cdd:PRK09764 164 fIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKF 230
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 11-86 5.95e-17

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 79.10  E-value: 5.95e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 742400311  11 HLAQGAVAPRYIQLATAIETAIRQQVLAAEAFLPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRVAMR 86
Cdd:COG1167    4 RLDRDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAAR 79
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
21-84 4.85e-15

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 69.05  E-value: 4.85e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 742400311  21 YIQLATAIETAIRQQVLAAEAFLPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRVA 84
Cdd:COG1725   12 YEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVA 75
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
24-83 2.29e-12

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 60.28  E-value: 2.29e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 742400311    24 LATAIETAIRQQVLAAEAFLPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRV 83
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
20-84 2.50e-12

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 64.18  E-value: 2.50e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 742400311  20 RYIQLATAIETAIRQQVLAAEAFLPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRVA 84
Cdd:COG2186    8 LAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVR 72
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 21-83 3.04e-11

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 57.24  E-value: 3.04e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 742400311   21 YIQLATAIETAIRQQVLAAEAFLPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRV 83
Cdd:pfam00392   2 YEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK14999 PRK14999
histidine utilization repressor; Provisional
 14-90 1.55e-05

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 44.92  E-value: 1.55e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 742400311  14 QGAVAPRYIQLATAIETAIRQQVLAAEAFLPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRVAMRIGYS 90
Cdd:PRK14999   7 RSAPAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQS 83
PRK10225 PRK10225
Uxu operon transcriptional regulator;
21-83 1.92e-05

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 44.63  E-value: 1.92e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 742400311  21 YIQLATAIETAIRQQVLAAEAFLPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRV 83
Cdd:PRK10225  11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYV 73
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
43-91 2.45e-05

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 44.24  E-value: 2.45e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 742400311  43 LPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRVAMRIGYSL 91
Cdd:PRK09464  34 LPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLWQSF 82
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 23-84 3.25e-05

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 43.99  E-value: 3.25e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 742400311  23 QLATAIETAIRQQVLAAEAFLPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRVA 84
Cdd:PRK09990  11 VVAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVA 72
HTH_CRP smart00419
helix_turn_helix, cAMP Regulatory protein;
47-79 4.28e-05

helix_turn_helix, cAMP Regulatory protein;


Pssm-ID: 128696 [Multi-domain]  Cd Length: 48  Bit Score: 40.12  E-value: 4.28e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 742400311    47 RQMAEGLALSRVTVSKAMKLLEEKGLISRQQGV 79
Cdd:smart00419  12 QEIAELLGLTRETVSRTLKRLEKEGLISREGGR 44
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 47-76 2.37e-04

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 38.42  E-value: 2.37e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 742400311  47 RQMAEGLALSRVTVSKAMKLLEEKGLISRQ 76
Cdd:cd00092   29 QEIADYLGLTRETVSRTLKELEEEGLISRR 58
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 23-83 4.18e-04

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 40.52  E-value: 4.18e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 742400311  23 QLATAIETAIRQQVLAAEAFLPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRV 83
Cdd:PRK10421   6 EVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI 66
PRK11523 PRK11523
transcriptional regulator ExuR;
21-83 1.03e-03

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 39.44  E-value: 1.03e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 742400311  21 YIQLATAIETAIRQQVLAAEAFLPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRV 83
Cdd:PRK11523  10 YQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHV 72
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
23-84 1.23e-03

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 39.14  E-value: 1.23e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 742400311  23 QLATAIETAIRQQVLAAEAFLPpERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGTRVA 84
Cdd:COG1802   15 QVYEALREAILSGELPPGERLS-EAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVA 75
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 25-81 1.48e-03

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 39.26  E-value: 1.48e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 742400311  25 ATAIETAIRQQV----LAAEAFLPPERQMAEGLALSRVTVSKAMKLLEEKGLISRQQGVGT 81
Cdd:PRK15481   7 ANEIFDSIRQLIqagrLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGT 67
HTH_Crp_2 pfam13545
Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain ...
 47-77 2.41e-03

Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain that is likely to bind DNA.


Pssm-ID: 463917 [Multi-domain]  Cd Length: 68  Bit Score: 35.51  E-value: 2.41e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 742400311   47 RQMAEGLALSRVTVSKAMKLLEEKGLISRQQ 77
Cdd:pfam13545  26 EDLADLLGTTRETVSRVLSELRREGLIERGR 56
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
48-87 2.88e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 36.72  E-value: 2.88e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 742400311  48 QMAEGLALSRVTVSKAMKLLEEKGLISRQ--QGV-----GTRVAMRI 87
Cdd:COG1321   29 DIAERLGVSPPSVTEMLKKLEEKGLVEYEpyGGItlteeGRELALRI 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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