hexulose-6-phosphate isomerase, putative; This family shows similarity by PSI-BLAST to other ...
6-282
2.44e-115
hexulose-6-phosphate isomerase, putative; This family shows similarity by PSI-BLAST to other isomerases. Putative identification as hexulose-6-phosphate isomerase is reported in Swiss-Prot, attributing a discussion in Genome Sci. Technol. 1:53-75(1996). This family is conserved at better than 40 % identity among the four known examples from three species: Escherichia coli (SgbU and SgaU), Haemophilus influenzae, and Mycoplasma pneumoniae. The rarity of the family, high level of conservation, and proposed catabolic role suggests lateral transfer may be a part of the evolutionary history of this protein. [Energy metabolism, Sugars]
Pssm-ID: 129633 Cd Length: 279 Bit Score: 333.36 E-value: 2.44e-115
AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester ...
10-278
2.30e-49
AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-hexulose 3-phosphate to D-fructose 6-phosphate, via cleaving the phosphoesterbond with the sugar.
Pssm-ID: 237986 Cd Length: 279 Bit Score: 164.80 E-value: 2.30e-49
Xylose isomerase-like TIM barrel; This TIM alpha/beta barrel structure is found in xylose ...
30-281
1.52e-48
Xylose isomerase-like TIM barrel; This TIM alpha/beta barrel structure is found in xylose isomerase and in endonuclease IV (EC:3.1.21.2). This domain is also found in the N termini of bacterial myo-inositol catabolism proteins. These are involved in the myo-inositol catabolism pathway, and is required for growth on myo-inositol in Rhizobium leguminosarum bv. viciae.
Pssm-ID: 426164 [Multi-domain] Cd Length: 248 Bit Score: 161.77 E-value: 1.52e-48
cobamide remodeling phosphodiesterase CbiR; Rare cobamides, analogs of B12 with critical ...
35-259
1.25e-03
cobamide remodeling phosphodiesterase CbiR; Rare cobamides, analogs of B12 with critical differences in the lower ligand, can become available for a salvage-like pathway to B12 biosynthesis through the action of enzymes that cleave the lower ligand. Members of this family are CbiR, a phosphodiesterase, which joins CbiZ, a previously discovered amidohydrolase, in the guild of cobamide remodeling enzymes.
Pssm-ID: 469174 Cd Length: 249 Bit Score: 39.54 E-value: 1.25e-03
hexulose-6-phosphate isomerase, putative; This family shows similarity by PSI-BLAST to other ...
6-282
2.44e-115
hexulose-6-phosphate isomerase, putative; This family shows similarity by PSI-BLAST to other isomerases. Putative identification as hexulose-6-phosphate isomerase is reported in Swiss-Prot, attributing a discussion in Genome Sci. Technol. 1:53-75(1996). This family is conserved at better than 40 % identity among the four known examples from three species: Escherichia coli (SgbU and SgaU), Haemophilus influenzae, and Mycoplasma pneumoniae. The rarity of the family, high level of conservation, and proposed catabolic role suggests lateral transfer may be a part of the evolutionary history of this protein. [Energy metabolism, Sugars]
Pssm-ID: 129633 Cd Length: 279 Bit Score: 333.36 E-value: 2.44e-115
AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester ...
10-278
2.30e-49
AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-hexulose 3-phosphate to D-fructose 6-phosphate, via cleaving the phosphoesterbond with the sugar.
Pssm-ID: 237986 Cd Length: 279 Bit Score: 164.80 E-value: 2.30e-49
Xylose isomerase-like TIM barrel; This TIM alpha/beta barrel structure is found in xylose ...
30-281
1.52e-48
Xylose isomerase-like TIM barrel; This TIM alpha/beta barrel structure is found in xylose isomerase and in endonuclease IV (EC:3.1.21.2). This domain is also found in the N termini of bacterial myo-inositol catabolism proteins. These are involved in the myo-inositol catabolism pathway, and is required for growth on myo-inositol in Rhizobium leguminosarum bv. viciae.
Pssm-ID: 426164 [Multi-domain] Cd Length: 248 Bit Score: 161.77 E-value: 1.52e-48
cobamide remodeling phosphodiesterase CbiR; Rare cobamides, analogs of B12 with critical ...
35-259
1.25e-03
cobamide remodeling phosphodiesterase CbiR; Rare cobamides, analogs of B12 with critical differences in the lower ligand, can become available for a salvage-like pathway to B12 biosynthesis through the action of enzymes that cleave the lower ligand. Members of this family are CbiR, a phosphodiesterase, which joins CbiZ, a previously discovered amidohydrolase, in the guild of cobamide remodeling enzymes.
Pssm-ID: 469174 Cd Length: 249 Bit Score: 39.54 E-value: 1.25e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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