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Conserved domains on  [gi|742509809|ref|WP_038964737|]
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L-lactate permease [Vibrio vulnificus]

Protein Classification

L-lactate permease( domain architecture ID 10004073)

L-lactate permease plays a role in L-lactate utilization by transporting L-lactate across the membrane

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LldP COG1620
L-lactate permease [Energy production and conversion];
1-555 0e+00

L-lactate permease [Energy production and conversion];


:

Pssm-ID: 441227  Cd Length: 520  Bit Score: 535.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809   1 MSETMLALLAFSPIVVAAILLVGLNWPAKKAMPVAFALTVVIALFGWDMSTTRVIASVLQGLGITVSVLWIVFGAIFLLN 80
Cdd:COG1620    1 MSLGLSALLALLPILVLFVLLVVLRWPAHKAMPIGLLVALLVALFVFGMPAGLALAATLQGALFGLPILWIVFGAILLYN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  81 TLKHTGAITTIRNGFTDISADRRVQAIIIAWCFGSFIEGASGFGTPAAIAAPLLVAIGFPALAAVLMGMMIQSTPVSFGA 160
Cdd:COG1620   81 TTVESGAFDVIRRSFASISPDRRVQALLIAFLFGAFLEGAAGFGTPVAITAPLLVGLGFPPLAAAGLALIANTAPVAFGA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 161 VGTPIIVGVN-KGLDthnisealiahgsswdiyLQQITSSVALIHATVGTIMPVLMAMMLTRFfgknRSWSEgldILPFA 239
Cdd:COG1620  161 VGTPIIVGAQvTGLD------------------ALEIGAMVGRQLPILSLLIPFLLVWILDGW----RGIKE---VWPAA 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 240 LFAGFAFTVPYALTGVFLGPEFPSLIGGLVGLAIVVTAAKkgFLVPKSQWDFEAEDKWPAEwlgslkiDLEQVQGKPMSL 319
Cdd:COG1620  216 LVAGLSFAVPQFLTANFLGPELPDIIAGLVGLAALVLFLR--FWKPKEIWDFAPEEEWPAE-------EEDAEKLSAMSL 286
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 320 VKAWTPYVLLAVILVASRVSADFKALLTG----ISISSGTILGEAGISTAFQPLYLPGGILVFVALLAVLIQAGSLKPMA 395
Cdd:COG1620  287 LKAWSPYLLLIVLLVLTRLPPPVKALLNSttlkIPWPGLLGAGTTGASYSFNPLYAPGTAILLAALITILLLRMSPGQAK 366
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 396 KALGESSKTLVGAGFVLVFTIPMVRIFINSGvnaadlasMPVTTANFAADLVGSAFPALSATVGALGAFIAGSNTVSNMM 475
Cdd:COG1620  367 RAFKETLKQLRGPILTLAFVLALAYVMNYSG--------MPATLGLALAAATGAAFPFFAPFLGWLGVFITGSDTSSNAL 438
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 476 FSQFQFEVAQTLTISSAVVVALQAVGAAAGNMIAIHNVVAASATVGLLGREGATLRKTIIPTFYYLVVTGIIGLTLIYGL 555
Cdd:COG1620  439 FGGLQFTTAEQLGLSPTLIVAAQSVGGVMGKMISPQNIVAAAAAVGLVGKEGEIIRKTLIPSLILLLLVGLLVLLQAYVL 518
 
Name Accession Description Interval E-value
LldP COG1620
L-lactate permease [Energy production and conversion];
1-555 0e+00

L-lactate permease [Energy production and conversion];


Pssm-ID: 441227  Cd Length: 520  Bit Score: 535.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809   1 MSETMLALLAFSPIVVAAILLVGLNWPAKKAMPVAFALTVVIALFGWDMSTTRVIASVLQGLGITVSVLWIVFGAIFLLN 80
Cdd:COG1620    1 MSLGLSALLALLPILVLFVLLVVLRWPAHKAMPIGLLVALLVALFVFGMPAGLALAATLQGALFGLPILWIVFGAILLYN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  81 TLKHTGAITTIRNGFTDISADRRVQAIIIAWCFGSFIEGASGFGTPAAIAAPLLVAIGFPALAAVLMGMMIQSTPVSFGA 160
Cdd:COG1620   81 TTVESGAFDVIRRSFASISPDRRVQALLIAFLFGAFLEGAAGFGTPVAITAPLLVGLGFPPLAAAGLALIANTAPVAFGA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 161 VGTPIIVGVN-KGLDthnisealiahgsswdiyLQQITSSVALIHATVGTIMPVLMAMMLTRFfgknRSWSEgldILPFA 239
Cdd:COG1620  161 VGTPIIVGAQvTGLD------------------ALEIGAMVGRQLPILSLLIPFLLVWILDGW----RGIKE---VWPAA 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 240 LFAGFAFTVPYALTGVFLGPEFPSLIGGLVGLAIVVTAAKkgFLVPKSQWDFEAEDKWPAEwlgslkiDLEQVQGKPMSL 319
Cdd:COG1620  216 LVAGLSFAVPQFLTANFLGPELPDIIAGLVGLAALVLFLR--FWKPKEIWDFAPEEEWPAE-------EEDAEKLSAMSL 286
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 320 VKAWTPYVLLAVILVASRVSADFKALLTG----ISISSGTILGEAGISTAFQPLYLPGGILVFVALLAVLIQAGSLKPMA 395
Cdd:COG1620  287 LKAWSPYLLLIVLLVLTRLPPPVKALLNSttlkIPWPGLLGAGTTGASYSFNPLYAPGTAILLAALITILLLRMSPGQAK 366
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 396 KALGESSKTLVGAGFVLVFTIPMVRIFINSGvnaadlasMPVTTANFAADLVGSAFPALSATVGALGAFIAGSNTVSNMM 475
Cdd:COG1620  367 RAFKETLKQLRGPILTLAFVLALAYVMNYSG--------MPATLGLALAAATGAAFPFFAPFLGWLGVFITGSDTSSNAL 438
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 476 FSQFQFEVAQTLTISSAVVVALQAVGAAAGNMIAIHNVVAASATVGLLGREGATLRKTIIPTFYYLVVTGIIGLTLIYGL 555
Cdd:COG1620  439 FGGLQFTTAEQLGLSPTLIVAAQSVGGVMGKMISPQNIVAAAAAVGLVGKEGEIIRKTLIPSLILLLLVGLLVLLQAYVL 518
lctP TIGR00795
L-lactate transport; The Lactate Permease (LctP) Family (TC 2.A.14) The only characterized ...
5-553 4.48e-92

L-lactate transport; The Lactate Permease (LctP) Family (TC 2.A.14) The only characterized member of this family, from E. coli, appears to catalyze lactate:H+ uptake. Members of this family have 12 probable TMS. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 162041  Cd Length: 530  Bit Score: 292.37  E-value: 4.48e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809    5 MLALLAFSPIVVAAILLVGLNWPAKKAMPVAFALTVVIALFGWDMSTTRVIASVLQGLGITV-SVLWIVFGAIFLLNTLK 83
Cdd:TIGR00795   7 LSAIVALLPILLFFFLLAVLKLKGYYAAPISVALSVIIALFYYKMPVIMTSAAFLYGFLYGLwPIAWIIIAAIFLYKLSV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809   84 HTGAITTIRNGFTDISADRRVQAIIIAWCFGSFIEGASGFGTPAAIAAPLLVAIGFPALAAVLMGMMIQSTPVSFGAVGT 163
Cdd:TIGR00795  87 KSGAFEIIRSSILSISPDRRIQVLLIGFCFGAFLEGAAGFGTPVAITAAILVGLGFKPLYAAGLCLIANTAPVAFGAVGI 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  164 PIIVGvnkgldthnisealiahGSSWDIYLQQITSSVALIHATVGTIMPVLMAMMLTRFFGKNRSWsegldilPFALFAG 243
Cdd:TIGR00795 167 PIWAG-----------------AQATGLSALEISSMTGFQLPFISLLIPFFLVFLMDGWKGIKETF-------PAVLVAG 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  244 FAFTVPYALTGVFLGPEFPSLIGGLVGLAIVVTAAKkgFLVPKSQWDFEAEdkwpaewlgslKIDLEQVQGKPMSLVKAW 323
Cdd:TIGR00795 223 LSFAIPQFLSSNYLGPELPSILGALVSLVITALFLK--FWQPKEIFRFNGK-----------LDAGEVSAHHICKIVKAW 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  324 TPYVLL-AVILVASRVSADFKALLTGISISSGTILGEAGI-----------------STAFQPLYLP-GGILVFVALLAV 384
Cdd:TIGR00795 290 SPFVLLtAFIVLWSIPPFKALFMKGGALIFSSFTFGSPGLsqhifklppivnqatnfPAVFKLLLIIaTGTSILLAAIVS 369
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  385 LIQAGSlkPMAKALGESSKTLvgagfVLVFTIPMVRIFINSGVNAADLASMPVTTANFAADlVGSAFPALSATVGALGAF 464
Cdd:TIGR00795 370 FFILRV--SISDAIGVFGETL-----KEMRLPILTIGMVLAFANVSNYSGMSKTLALALAH-TGLAFTFFSPFLGWLGVF 441
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  465 IAGSNTVSNMMFSQFQFEVAQTLTISSAVVVALQAVGAAAGNMIAIHNVVAASATVGLLGREGATLRKTIIPTFYYLVVT 544
Cdd:TIGR00795 442 LTGSDTSSNLLFGSLQLLTAEQIGLPETLLLAANTVGGVMGKMISPQSIAIACAAVGLVGQESDLFRKTVKYSLIYAIIV 521

                  ....*....
gi 742509809  545 GIIGLTLIY 553
Cdd:TIGR00795 522 GVVALLLAY 530
Lactate_perm pfam02652
L-lactate permease; L-lactate permease is an integral membrane protein probably involved in ...
5-547 3.71e-89

L-lactate permease; L-lactate permease is an integral membrane protein probably involved in L-lactate transport.


Pssm-ID: 280762  Cd Length: 522  Bit Score: 284.27  E-value: 3.71e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809    5 MLALLAFSPIVVAAILLVGLNWPAKKAMPVAFALTVVIALFGWDMSTTRVIASVLQGLGITV-SVLWIVFGAIFLLNTLK 83
Cdd:pfam02652   1 LSALVALTPILLFFFLLAVLKMKGYYAAPISLAVTVIIALLYYKMPVENTISSVLYGALYGLwPIAWIIIAAIFLYKISV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809   84 HTGAITTIRNGFTDISADRRVQAIIIAWCFGSFIEGASGFGTPAAIAAPLLVAIGFPALAAVLMGMMIQSTPVSFGAVGT 163
Cdd:pfam02652  81 KSGAFEIIRSSILNISPDRRIQVLLIGFCFGAFLEGAAGFGTPVAITAAILVGLGFKPLYAAGLCLIANTAPVAFGAVGI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  164 PIIVGVNKGLDTHNIsealiahgsswdiylqqITSSVALIHATVGTIMPVLMAMMLTRFFGKNRSWsegldilPFALFAG 243
Cdd:pfam02652 161 PITAGAGATGLSALE-----------------ISSMVGFQLPFISLLIPFFLVFLMDGFKGIKETF-------PAVLVSG 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  244 FAFTVPYALTGVFLGPEFPSLIGGLVGLAIVVTAAKkgFLVPKSQWDFEAEDKwpaewlgslkiDLEQVQGKPMSLVKAW 323
Cdd:pfam02652 217 LSFAIPQFLSSNVLGPELPSILGALVSLVITALFLK--FWQPKEIFRFAGKGD-----------SGATSALRAGKIVKAW 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  324 TPYVLLAVILVASRVSAdFKALLTGIS------------------ISSGTILGEAGISTA---FQPLYLPGGILVFVALL 382
Cdd:pfam02652 284 SPFVLLTAFIVLWSIPQ-FKALFQEGGalytstfnfefpeisqliFSIPPIVGEATPFPVvfkFKLLYSPGTIIFLAALL 362
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  383 AVLIQAGSLKPMAKALGESSKTLVGAGFVLVFTIPMVRIFINSGVnaadLASMPVTTANfaadlVGSAFPALSATVGALG 462
Cdd:pfam02652 363 SIFILKVSSSDALSIFKETLKEMALPIITIIFVLAFANLMNYSGM----SKTLALALAH-----TGSAFTFFSPFLGWLG 433
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  463 AFIAGSNTVSNMMFSQFQFEVAQTLTISSAVVVALQAVGAAAGNMIAIHNVVAASATVGLLGREGATLRKTIIPTFYYLV 542
Cdd:pfam02652 434 VFLTGSDTSSNLLFGSLQLVTAEQIGLPPVLLLAANTVGGVMGKMISPQSIAIACAAVGLAGKESDLFRKTIKYSLIYAI 513

                  ....*
gi 742509809  543 VTGII 547
Cdd:pfam02652 514 IVGVV 518
PRK10420 PRK10420
L-lactate permease; Provisional
7-547 1.86e-41

L-lactate permease; Provisional


Pssm-ID: 182445  Cd Length: 551  Bit Score: 157.31  E-value: 1.86e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809   7 ALLAFSPIVVAAILLVGLNWPAKKAMPVAFALTVVIALFGWDMSTTRVIASVLQGLGITV-SVLWIVFGAIFLLNTLKHT 85
Cdd:PRK10420  18 SLIASLPILFFFFALIKLKLKGYVAASWTVAIALAVALLFYKMPVANALASVVYGFFYGLwPIAWIIIAAVFVYKISVKT 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  86 GAITTIRNGFTDISADRRVQAIIIAWCFGSFIEGASGFGTPAAIAAPLLVAIGFPALAAVLMGMMIQSTPVSFGAVGTPI 165
Cdd:PRK10420  98 GQFDIIRSSILSITPDQRLQMLIVGFCFGAFLEGAAGFGAPVAITAALLVGLGFKPLYAAGLCLIVNTAPVAFGAMGIPI 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 166 IV-GVNKGLDTHNISEaliahgsswdiylqqitssvalihaTVGTIMPVLMAMMLTRFFGKNRSWSEGLDILPFALFAGF 244
Cdd:PRK10420 178 LVaGQVTGIDSFEIGQ-------------------------MVGRQLPFLTIIVLFWIMAIMDGWRGVKETWPAVVVAGG 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 245 AFTVPYALTGVFLGPEFPSLIGGLVGLAIVVTAAKkgFLVPKSQWDF-EAEDKWPAEWLGSLKIDLEQVqgkpmslVKAW 323
Cdd:PRK10420 233 SFAIAQYLSSNFIGPELPDIISSLVSLVCLTLFLK--RWQPVRIFRFgDLGASQVDMTLAHTGYTAGQV-------LRAW 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 324 TPYVLLAVILVASRVSAdFKAL------------------LTGISISSGTILGEAGISTA---FQPLYLPGGILVFVALL 382
Cdd:PRK10420 304 SPFLFLTATVTLWSIPP-FKALfasggalyewvinipvpyLDKLVARMPPVVSEATAYAAvykFDWFSATGTAILFAALL 382
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 383 AVLIQAGSLKPMAKALGESSKTLVgagfVLVFTIPMVRIFINSGvNAADLASmpvtTANFAADLVGSAFPALSATVGALG 462
Cdd:PRK10420 383 SIVWLKMKPSDAISTFGSTLKELA----LPIYSIGMVLAFAFIS-NYSGLSS----TLALALAHTGHAFTFFSPFLGWLG 453
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 463 AFIAGSNTVSNMMFSQFQFEVAQTLTISSAVVVALQAVGAAAGNMIAIHNVVAASATVGLLGREGATLRKTIIPTFYYLV 542
Cdd:PRK10420 454 VFLTGSDTSSNALFAALQATAAQQIGVSDVLLVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTC 533

                 ....*
gi 742509809 543 VTGII 547
Cdd:PRK10420 534 MVGVI 538
 
Name Accession Description Interval E-value
LldP COG1620
L-lactate permease [Energy production and conversion];
1-555 0e+00

L-lactate permease [Energy production and conversion];


Pssm-ID: 441227  Cd Length: 520  Bit Score: 535.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809   1 MSETMLALLAFSPIVVAAILLVGLNWPAKKAMPVAFALTVVIALFGWDMSTTRVIASVLQGLGITVSVLWIVFGAIFLLN 80
Cdd:COG1620    1 MSLGLSALLALLPILVLFVLLVVLRWPAHKAMPIGLLVALLVALFVFGMPAGLALAATLQGALFGLPILWIVFGAILLYN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  81 TLKHTGAITTIRNGFTDISADRRVQAIIIAWCFGSFIEGASGFGTPAAIAAPLLVAIGFPALAAVLMGMMIQSTPVSFGA 160
Cdd:COG1620   81 TTVESGAFDVIRRSFASISPDRRVQALLIAFLFGAFLEGAAGFGTPVAITAPLLVGLGFPPLAAAGLALIANTAPVAFGA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 161 VGTPIIVGVN-KGLDthnisealiahgsswdiyLQQITSSVALIHATVGTIMPVLMAMMLTRFfgknRSWSEgldILPFA 239
Cdd:COG1620  161 VGTPIIVGAQvTGLD------------------ALEIGAMVGRQLPILSLLIPFLLVWILDGW----RGIKE---VWPAA 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 240 LFAGFAFTVPYALTGVFLGPEFPSLIGGLVGLAIVVTAAKkgFLVPKSQWDFEAEDKWPAEwlgslkiDLEQVQGKPMSL 319
Cdd:COG1620  216 LVAGLSFAVPQFLTANFLGPELPDIIAGLVGLAALVLFLR--FWKPKEIWDFAPEEEWPAE-------EEDAEKLSAMSL 286
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 320 VKAWTPYVLLAVILVASRVSADFKALLTG----ISISSGTILGEAGISTAFQPLYLPGGILVFVALLAVLIQAGSLKPMA 395
Cdd:COG1620  287 LKAWSPYLLLIVLLVLTRLPPPVKALLNSttlkIPWPGLLGAGTTGASYSFNPLYAPGTAILLAALITILLLRMSPGQAK 366
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 396 KALGESSKTLVGAGFVLVFTIPMVRIFINSGvnaadlasMPVTTANFAADLVGSAFPALSATVGALGAFIAGSNTVSNMM 475
Cdd:COG1620  367 RAFKETLKQLRGPILTLAFVLALAYVMNYSG--------MPATLGLALAAATGAAFPFFAPFLGWLGVFITGSDTSSNAL 438
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 476 FSQFQFEVAQTLTISSAVVVALQAVGAAAGNMIAIHNVVAASATVGLLGREGATLRKTIIPTFYYLVVTGIIGLTLIYGL 555
Cdd:COG1620  439 FGGLQFTTAEQLGLSPTLIVAAQSVGGVMGKMISPQNIVAAAAAVGLVGKEGEIIRKTLIPSLILLLLVGLLVLLQAYVL 518
lctP TIGR00795
L-lactate transport; The Lactate Permease (LctP) Family (TC 2.A.14) The only characterized ...
5-553 4.48e-92

L-lactate transport; The Lactate Permease (LctP) Family (TC 2.A.14) The only characterized member of this family, from E. coli, appears to catalyze lactate:H+ uptake. Members of this family have 12 probable TMS. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 162041  Cd Length: 530  Bit Score: 292.37  E-value: 4.48e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809    5 MLALLAFSPIVVAAILLVGLNWPAKKAMPVAFALTVVIALFGWDMSTTRVIASVLQGLGITV-SVLWIVFGAIFLLNTLK 83
Cdd:TIGR00795   7 LSAIVALLPILLFFFLLAVLKLKGYYAAPISVALSVIIALFYYKMPVIMTSAAFLYGFLYGLwPIAWIIIAAIFLYKLSV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809   84 HTGAITTIRNGFTDISADRRVQAIIIAWCFGSFIEGASGFGTPAAIAAPLLVAIGFPALAAVLMGMMIQSTPVSFGAVGT 163
Cdd:TIGR00795  87 KSGAFEIIRSSILSISPDRRIQVLLIGFCFGAFLEGAAGFGTPVAITAAILVGLGFKPLYAAGLCLIANTAPVAFGAVGI 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  164 PIIVGvnkgldthnisealiahGSSWDIYLQQITSSVALIHATVGTIMPVLMAMMLTRFFGKNRSWsegldilPFALFAG 243
Cdd:TIGR00795 167 PIWAG-----------------AQATGLSALEISSMTGFQLPFISLLIPFFLVFLMDGWKGIKETF-------PAVLVAG 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  244 FAFTVPYALTGVFLGPEFPSLIGGLVGLAIVVTAAKkgFLVPKSQWDFEAEdkwpaewlgslKIDLEQVQGKPMSLVKAW 323
Cdd:TIGR00795 223 LSFAIPQFLSSNYLGPELPSILGALVSLVITALFLK--FWQPKEIFRFNGK-----------LDAGEVSAHHICKIVKAW 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  324 TPYVLL-AVILVASRVSADFKALLTGISISSGTILGEAGI-----------------STAFQPLYLP-GGILVFVALLAV 384
Cdd:TIGR00795 290 SPFVLLtAFIVLWSIPPFKALFMKGGALIFSSFTFGSPGLsqhifklppivnqatnfPAVFKLLLIIaTGTSILLAAIVS 369
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  385 LIQAGSlkPMAKALGESSKTLvgagfVLVFTIPMVRIFINSGVNAADLASMPVTTANFAADlVGSAFPALSATVGALGAF 464
Cdd:TIGR00795 370 FFILRV--SISDAIGVFGETL-----KEMRLPILTIGMVLAFANVSNYSGMSKTLALALAH-TGLAFTFFSPFLGWLGVF 441
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  465 IAGSNTVSNMMFSQFQFEVAQTLTISSAVVVALQAVGAAAGNMIAIHNVVAASATVGLLGREGATLRKTIIPTFYYLVVT 544
Cdd:TIGR00795 442 LTGSDTSSNLLFGSLQLLTAEQIGLPETLLLAANTVGGVMGKMISPQSIAIACAAVGLVGQESDLFRKTVKYSLIYAIIV 521

                  ....*....
gi 742509809  545 GIIGLTLIY 553
Cdd:TIGR00795 522 GVVALLLAY 530
Lactate_perm pfam02652
L-lactate permease; L-lactate permease is an integral membrane protein probably involved in ...
5-547 3.71e-89

L-lactate permease; L-lactate permease is an integral membrane protein probably involved in L-lactate transport.


Pssm-ID: 280762  Cd Length: 522  Bit Score: 284.27  E-value: 3.71e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809    5 MLALLAFSPIVVAAILLVGLNWPAKKAMPVAFALTVVIALFGWDMSTTRVIASVLQGLGITV-SVLWIVFGAIFLLNTLK 83
Cdd:pfam02652   1 LSALVALTPILLFFFLLAVLKMKGYYAAPISLAVTVIIALLYYKMPVENTISSVLYGALYGLwPIAWIIIAAIFLYKISV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809   84 HTGAITTIRNGFTDISADRRVQAIIIAWCFGSFIEGASGFGTPAAIAAPLLVAIGFPALAAVLMGMMIQSTPVSFGAVGT 163
Cdd:pfam02652  81 KSGAFEIIRSSILNISPDRRIQVLLIGFCFGAFLEGAAGFGTPVAITAAILVGLGFKPLYAAGLCLIANTAPVAFGAVGI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  164 PIIVGVNKGLDTHNIsealiahgsswdiylqqITSSVALIHATVGTIMPVLMAMMLTRFFGKNRSWsegldilPFALFAG 243
Cdd:pfam02652 161 PITAGAGATGLSALE-----------------ISSMVGFQLPFISLLIPFFLVFLMDGFKGIKETF-------PAVLVSG 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  244 FAFTVPYALTGVFLGPEFPSLIGGLVGLAIVVTAAKkgFLVPKSQWDFEAEDKwpaewlgslkiDLEQVQGKPMSLVKAW 323
Cdd:pfam02652 217 LSFAIPQFLSSNVLGPELPSILGALVSLVITALFLK--FWQPKEIFRFAGKGD-----------SGATSALRAGKIVKAW 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  324 TPYVLLAVILVASRVSAdFKALLTGIS------------------ISSGTILGEAGISTA---FQPLYLPGGILVFVALL 382
Cdd:pfam02652 284 SPFVLLTAFIVLWSIPQ-FKALFQEGGalytstfnfefpeisqliFSIPPIVGEATPFPVvfkFKLLYSPGTIIFLAALL 362
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  383 AVLIQAGSLKPMAKALGESSKTLVGAGFVLVFTIPMVRIFINSGVnaadLASMPVTTANfaadlVGSAFPALSATVGALG 462
Cdd:pfam02652 363 SIFILKVSSSDALSIFKETLKEMALPIITIIFVLAFANLMNYSGM----SKTLALALAH-----TGSAFTFFSPFLGWLG 433
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  463 AFIAGSNTVSNMMFSQFQFEVAQTLTISSAVVVALQAVGAAAGNMIAIHNVVAASATVGLLGREGATLRKTIIPTFYYLV 542
Cdd:pfam02652 434 VFLTGSDTSSNLLFGSLQLVTAEQIGLPPVLLLAANTVGGVMGKMISPQSIAIACAAVGLAGKESDLFRKTIKYSLIYAI 513

                  ....*
gi 742509809  543 VTGII 547
Cdd:pfam02652 514 IVGVV 518
PRK10420 PRK10420
L-lactate permease; Provisional
7-547 1.86e-41

L-lactate permease; Provisional


Pssm-ID: 182445  Cd Length: 551  Bit Score: 157.31  E-value: 1.86e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809   7 ALLAFSPIVVAAILLVGLNWPAKKAMPVAFALTVVIALFGWDMSTTRVIASVLQGLGITV-SVLWIVFGAIFLLNTLKHT 85
Cdd:PRK10420  18 SLIASLPILFFFFALIKLKLKGYVAASWTVAIALAVALLFYKMPVANALASVVYGFFYGLwPIAWIIIAAVFVYKISVKT 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  86 GAITTIRNGFTDISADRRVQAIIIAWCFGSFIEGASGFGTPAAIAAPLLVAIGFPALAAVLMGMMIQSTPVSFGAVGTPI 165
Cdd:PRK10420  98 GQFDIIRSSILSITPDQRLQMLIVGFCFGAFLEGAAGFGAPVAITAALLVGLGFKPLYAAGLCLIVNTAPVAFGAMGIPI 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 166 IV-GVNKGLDTHNISEaliahgsswdiylqqitssvalihaTVGTIMPVLMAMMLTRFFGKNRSWSEGLDILPFALFAGF 244
Cdd:PRK10420 178 LVaGQVTGIDSFEIGQ-------------------------MVGRQLPFLTIIVLFWIMAIMDGWRGVKETWPAVVVAGG 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 245 AFTVPYALTGVFLGPEFPSLIGGLVGLAIVVTAAKkgFLVPKSQWDF-EAEDKWPAEWLGSLKIDLEQVqgkpmslVKAW 323
Cdd:PRK10420 233 SFAIAQYLSSNFIGPELPDIISSLVSLVCLTLFLK--RWQPVRIFRFgDLGASQVDMTLAHTGYTAGQV-------LRAW 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 324 TPYVLLAVILVASRVSAdFKAL------------------LTGISISSGTILGEAGISTA---FQPLYLPGGILVFVALL 382
Cdd:PRK10420 304 SPFLFLTATVTLWSIPP-FKALfasggalyewvinipvpyLDKLVARMPPVVSEATAYAAvykFDWFSATGTAILFAALL 382
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 383 AVLIQAGSLKPMAKALGESSKTLVgagfVLVFTIPMVRIFINSGvNAADLASmpvtTANFAADLVGSAFPALSATVGALG 462
Cdd:PRK10420 383 SIVWLKMKPSDAISTFGSTLKELA----LPIYSIGMVLAFAFIS-NYSGLSS----TLALALAHTGHAFTFFSPFLGWLG 453
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 463 AFIAGSNTVSNMMFSQFQFEVAQTLTISSAVVVALQAVGAAAGNMIAIHNVVAASATVGLLGREGATLRKTIIPTFYYLV 542
Cdd:PRK10420 454 VFLTGSDTSSNALFAALQATAAQQIGVSDVLLVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTC 533

                 ....*
gi 742509809 543 VTGII 547
Cdd:PRK10420 534 MVGVI 538
PRK09695 PRK09695
glycolate permease GlcA;
7-553 2.66e-33

glycolate permease GlcA;


Pssm-ID: 182032  Cd Length: 560  Bit Score: 134.03  E-value: 2.66e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809   7 ALLAFSPIVVAAILLVGLNWPAKKAMPVAFALTVVIALFGWDMSTTRVIASVLQGLGITV-SVLWIVFGAIFLLNTLKHT 85
Cdd:PRK09695  18 ALVALIPIIFFFVALAVLRLKGHVAGAITLILSILIAIFAFKMPIDMAFAAAGYGFIYGLwPIAWIIVAAVFLYKLTVAS 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809  86 GAITTIRNGFTDISADRRVQAIIIAWCFGSFIEGASGFGTPAAIAAPLLVAIGFPALAAVLMGMMIQSTPVSFGAVGTPI 165
Cdd:PRK09695  98 GQFDIIRSSVISITDDQRLQVLLIGFSFGALLEGAAGFGAPVAITGALLVGLGFKPLYAAGLCLIANTAPVAFGALGVPI 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 166 IV-GVNKGLDTHNISealiahgsswdiylqqitssvalihATVGTIMPVLMAMMLTRFFGKNRSWSEGLDILPFALFAGF 244
Cdd:PRK09695 178 LVaGQVTGIDPFHIG-------------------------AMAGRQLPFLSVLVPFWLVAMMDGWKGVKETWPAALVAGG 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 245 AFTVPYALTGVFLGPEFPSLIGGLVglAIVVTAAKKGFLVPKSQWDFEAEdkwpAEWLGSLKIDLEQVQGKPMS------ 318
Cdd:PRK09695 233 SFAVTQFFTSNYIGPELPDITSALV--SIVSLALFLKVWRPKNTETAISM----GQSAGAMVVNKPSSGGPVPSeyslgq 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 319 LVKAWTPYVLLAViLVASRVSADFKAL------------------LTGISISSGTILGEAGISTA---FQPLYLPGGILV 377
Cdd:PRK09695 307 IIRAWSPFLILTV-LVTIWTMKPFKALfapggafyslvinfqiphLHQQVLKAAPIVAQPTPMDAvfkFDPLSAGGTAIF 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 378 FVALLAVLIQAGSLKpmaKALGESSKTLVGAGFVlVFTIPMVRIFinsgVNAADLASMPVTTANFAADlVGSAFPALSAT 457
Cdd:PRK09695 386 IAAIISIFILGVGIK---KGIGVFAETLISLKWP-ILSIGMVLAF----AFVTNYSGMSTTLALVLAG-TGVMFPFFSPF 456
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742509809 458 VGALGAFIAGSNTVSNMMFSQFQFEVAQTLTISSAVVVALQAVGAAAGNMIAIHNVVAASATVGLLGREGATLRKTIIPT 537
Cdd:PRK09695 457 LGWLGVFLTGSDTSSNALFGSLQSTTAQQINVSDTLLVAANTSGGVTGKMISPQSIAVACAATGMVGRESELFRYTVKHS 536
                        570
                 ....*....|....*.
gi 742509809 538 FYYLVVTGIIGLTLIY 553
Cdd:PRK09695 537 LIFASVIGIITLLQAY 552
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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