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Conserved domains on  [gi|743521987|ref|WP_039039282|]
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MULTISPECIES: carboxymuconolactone decarboxylase family protein [Aeromonas]

Protein Classification

carboxymuconolactone decarboxylase family protein( domain architecture ID 10001777)

carboxymuconolactone decarboxylase (CMD) family protein similar to alkyl hydroperoxide reductase AhpD, which is required for the reduction of the AhpC active site cysteine residues to regenerate its enzyme activity; carboxymuconolactone d

CATH:  1.20.1290.10
Gene Ontology:  GO:0051920
PubMed:  9495744
SCOP:  4000771

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 25-128 2.29e-27

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


:

Pssm-ID: 440364  Cd Length: 114  Bit Score: 97.71  E-value: 2.29e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743521987  25 TRVAASLDALSPELAELVlGFAFADVLARPGIDLCTREMLTVATLMGMGtAPGQLEFHIRAALNVGVSRETIIEILLQVA 104
Cdd:COG0599   12 PRALEALAEFAPEFAEAF-EALFGDVWARGALDPKTRELITLAALAALG-CEPCLKAHVRAALNAGATREEIAEALLVAA 89

                         90       100
                 ....*....|....*....|....
gi 743521987 105 VYAGVPACMNGISAARSAFAAHDK 128
Cdd:COG0599   90 VYAGFPAALNALRAALEVLEELGA 113
 
Name Accession Description Interval E-value
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 25-128 2.29e-27

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 97.71  E-value: 2.29e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743521987  25 TRVAASLDALSPELAELVlGFAFADVLARPGIDLCTREMLTVATLMGMGtAPGQLEFHIRAALNVGVSRETIIEILLQVA 104
Cdd:COG0599   12 PRALEALAEFAPEFAEAF-EALFGDVWARGALDPKTRELITLAALAALG-CEPCLKAHVRAALNAGATREEIAEALLVAA 89

                         90       100
                 ....*....|....*....|....
gi 743521987 105 VYAGVPACMNGISAARSAFAAHDK 128
Cdd:COG0599   90 VYAGFPAALNALRAALEVLEELGA 113
decarb_PcaC TIGR02425
4-carboxymuconolactone decarboxylase; Members of this family are 4-carboxymuconolactone ...
 26-125 7.96e-20

4-carboxymuconolactone decarboxylase; Members of this family are 4-carboxymuconolactone decarboxylase, which catalyzes the third step in the catabolism of protocatechuate (and therefore the fourth step in the catabolism of para-hydroxybenzoate, of 3-hydroxybenzoate, of vanillate, etc.). Most members of this family are encoded within protocatechuate catabolism operons. This protein is sometimes found as a fusion protein with other enzymes of the pathway, as in Rhodococcus opacus, Streptomyces avermitilis, and Caulobacter crescentus. [Energy metabolism, Other]


Pssm-ID: 131478  Cd Length: 123  Bit Score: 78.64  E-value: 7.96e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743521987   26 RVAASLDALSPELAELVLGFAFADVLARPGIDLCTREMLTVATLMGMGTAPgQLEFHIRAALNVGVSRETIIEILLQVAV 105
Cdd:TIGR02425  23 RALAATTDFDQPFQELITEYAWGTVWTRPGLTKRERSLVTIALLAALGRDE-ELAMHVRATANTGVTEDDIKEVLLHVAI 101

                          90       100
                  ....*....|....*....|
gi 743521987  106 YAGVPACMNGISAARSAFAA 125
Cdd:TIGR02425 102 YAGVPAANHAFALAKEALAE 121
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 36-120 1.45e-13

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 61.56  E-value: 1.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743521987   36 PELAELVLGFAFADVlARPGIDLCTREMLTVATLMGMGTAPgQLEFHIRAALNVGVSRETIIEILLQVAVYAGVPACMNG 115
Cdd:pfam02627   1 PELLAALTALAFGLL-WDGGLDPKTRELIALAVSAANGCAY-CLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAA 78


                  ....*
gi 743521987  116 ISAAR 120
Cdd:pfam02627  79 LAAAE 83
 
Name Accession Description Interval E-value
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 25-128 2.29e-27

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 97.71  E-value: 2.29e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743521987  25 TRVAASLDALSPELAELVlGFAFADVLARPGIDLCTREMLTVATLMGMGtAPGQLEFHIRAALNVGVSRETIIEILLQVA 104
Cdd:COG0599   12 PRALEALAEFAPEFAEAF-EALFGDVWARGALDPKTRELITLAALAALG-CEPCLKAHVRAALNAGATREEIAEALLVAA 89

                         90       100
                 ....*....|....*....|....
gi 743521987 105 VYAGVPACMNGISAARSAFAAHDK 128
Cdd:COG0599   90 VYAGFPAALNALRAALEVLEELGA 113
decarb_PcaC TIGR02425
4-carboxymuconolactone decarboxylase; Members of this family are 4-carboxymuconolactone ...
 26-125 7.96e-20

4-carboxymuconolactone decarboxylase; Members of this family are 4-carboxymuconolactone decarboxylase, which catalyzes the third step in the catabolism of protocatechuate (and therefore the fourth step in the catabolism of para-hydroxybenzoate, of 3-hydroxybenzoate, of vanillate, etc.). Most members of this family are encoded within protocatechuate catabolism operons. This protein is sometimes found as a fusion protein with other enzymes of the pathway, as in Rhodococcus opacus, Streptomyces avermitilis, and Caulobacter crescentus. [Energy metabolism, Other]


Pssm-ID: 131478  Cd Length: 123  Bit Score: 78.64  E-value: 7.96e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743521987   26 RVAASLDALSPELAELVLGFAFADVLARPGIDLCTREMLTVATLMGMGTAPgQLEFHIRAALNVGVSRETIIEILLQVAV 105
Cdd:TIGR02425  23 RALAATTDFDQPFQELITEYAWGTVWTRPGLTKRERSLVTIALLAALGRDE-ELAMHVRATANTGVTEDDIKEVLLHVAI 101

                          90       100
                  ....*....|....*....|
gi 743521987  106 YAGVPACMNGISAARSAFAA 125
Cdd:TIGR02425 102 YAGVPAANHAFALAKEALAE 121
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 36-120 1.45e-13

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 61.56  E-value: 1.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743521987   36 PELAELVLGFAFADVlARPGIDLCTREMLTVATLMGMGTAPgQLEFHIRAALNVGVSRETIIEILLQVAVYAGVPACMNG 115
Cdd:pfam02627   1 PELLAALTALAFGLL-WDGGLDPKTRELIALAVSAANGCAY-CLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAA 78


                  ....*
gi 743521987  116 ISAAR 120
Cdd:pfam02627  79 LAAAE 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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