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Conserved domains on  [gi|743522741|ref|WP_039040023|]
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MULTISPECIES: Co2+/Mg2+ efflux protein ApaG [Aeromonas]

Protein Classification

Co(2+)/Mg(2+) efflux protein ApaG( domain architecture ID 10012415)

Co(2+)/Mg(2+) efflux protein ApaG adopts a fibronectin type III (FN3) fold

CATH:  2.60.40.1470
Gene Ontology:  GO:0005515
SCOP:  4007551

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
apaG PRK05461
CO2+/MG2+ efflux protein ApaG; Reviewed
 1-120 7.37e-65

CO2+/MG2+ efflux protein ApaG; Reviewed


:

Pssm-ID: 180098  Cd Length: 127  Bit Score: 192.28  E-value: 7.37e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743522741   1 MTQARIVVRPHPSYVAGTADPYH----FLYRIEIENLGPGTVQLLHRRWLITDANGKMLEVEGPGVVGEQPLIAPGETFS 76
Cdd:PRK05461   4 AVTYGIEVSVQPRYLEEQSDPEEgryvFAYTITIENLGRVPVQLLSRHWLITDANGRVQEVRGEGVVGEQPVLAPGESFE 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 743522741  77 YQSGVPLATPLGVMEGSYILQDESGQRFEAPIAPFTLAVPNIIN 120
Cdd:PRK05461  84 YTSGAVLETPSGTMQGHYQMVDEDGERFEVPIPPFRLAVPRTLH 127
 
Name Accession Description Interval E-value
apaG PRK05461
CO2+/MG2+ efflux protein ApaG; Reviewed
 1-120 7.37e-65

CO2+/MG2+ efflux protein ApaG; Reviewed


Pssm-ID: 180098  Cd Length: 127  Bit Score: 192.28  E-value: 7.37e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743522741   1 MTQARIVVRPHPSYVAGTADPYH----FLYRIEIENLGPGTVQLLHRRWLITDANGKMLEVEGPGVVGEQPLIAPGETFS 76
Cdd:PRK05461   4 AVTYGIEVSVQPRYLEEQSDPEEgryvFAYTITIENLGRVPVQLLSRHWLITDANGRVQEVRGEGVVGEQPVLAPGESFE 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 743522741  77 YQSGVPLATPLGVMEGSYILQDESGQRFEAPIAPFTLAVPNIIN 120
Cdd:PRK05461  84 YTSGAVLETPSGTMQGHYQMVDEDGERFEVPIPPFRLAVPRTLH 127
ApaG COG2967
Uncharacterized conserved protein ApaG affecting Mg2+/Co2+ transport [Inorganic ion transport ...
 5-118 2.90e-58

Uncharacterized conserved protein ApaG affecting Mg2+/Co2+ transport [Inorganic ion transport and metabolism];


Pssm-ID: 442207  Cd Length: 119  Bit Score: 175.29  E-value: 2.90e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743522741   5 RIVVRPHPSYVAGTADP----YHFLYRIEIENLGPGTVQLLHRRWLITDANGKMLEVEGPGVVGEQPLIAPGETFSYQSG 80
Cdd:COG2967    2 GIKVSVETEYLPEQSDPeegrYVFAYTITIENLGDVTVQLLSRHWIITDANGKVQEVEGEGVVGEQPVLAPGESFEYTSG 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 743522741  81 VPLATPLGVMEGSYILQDESGQRFEAPIAPFTLAVPNI 118
Cdd:COG2967   82 CVLETPVGTMQGSYQMVDEDGERFDVPIPPFSLAAPRA 119
DUF525 pfam04379
ApaG domain; The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins ...
 22-98 5.79e-44

ApaG domain; The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins and in eukaryotic F-box proteins. The domain is named after the bacterial apaG protein, of which it forms the core. The domain also occurs in the C-terminal part of eukaryotic proteins with an N-terminal F-box domain. The Salmonella typhimurium apaG domain protein corD is involved in Co(2+) resistance and Mg(2+) efflux. Tertiary structures from different apaG proteins show a fold of several beta-sheets. The apaG domain may be involved in protein-protein interactions which could be implicated in substrate-specificity.


Pssm-ID: 461283  Cd Length: 87  Bit Score: 138.37  E-value: 5.79e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 743522741   22 YHFLYRIEIENLGPGTVQLLHRRWLITDANGKMLEVEGPGVVGEQPLIAPGETFSYQSGVPLATPLGVMEGSYILQD 98
Cdd:pfam04379  11 YVFAYTIRIENLGDSSVQLLSRHWIITDANGKVEEVRGEGVVGEQPVLAPGESFEYTSGCPLETPSGSMEGSYTMVR 87
 
Name Accession Description Interval E-value
apaG PRK05461
CO2+/MG2+ efflux protein ApaG; Reviewed
 1-120 7.37e-65

CO2+/MG2+ efflux protein ApaG; Reviewed


Pssm-ID: 180098  Cd Length: 127  Bit Score: 192.28  E-value: 7.37e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743522741   1 MTQARIVVRPHPSYVAGTADPYH----FLYRIEIENLGPGTVQLLHRRWLITDANGKMLEVEGPGVVGEQPLIAPGETFS 76
Cdd:PRK05461   4 AVTYGIEVSVQPRYLEEQSDPEEgryvFAYTITIENLGRVPVQLLSRHWLITDANGRVQEVRGEGVVGEQPVLAPGESFE 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 743522741  77 YQSGVPLATPLGVMEGSYILQDESGQRFEAPIAPFTLAVPNIIN 120
Cdd:PRK05461  84 YTSGAVLETPSGTMQGHYQMVDEDGERFEVPIPPFRLAVPRTLH 127
ApaG COG2967
Uncharacterized conserved protein ApaG affecting Mg2+/Co2+ transport [Inorganic ion transport ...
 5-118 2.90e-58

Uncharacterized conserved protein ApaG affecting Mg2+/Co2+ transport [Inorganic ion transport and metabolism];


Pssm-ID: 442207  Cd Length: 119  Bit Score: 175.29  E-value: 2.90e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743522741   5 RIVVRPHPSYVAGTADP----YHFLYRIEIENLGPGTVQLLHRRWLITDANGKMLEVEGPGVVGEQPLIAPGETFSYQSG 80
Cdd:COG2967    2 GIKVSVETEYLPEQSDPeegrYVFAYTITIENLGDVTVQLLSRHWIITDANGKVQEVEGEGVVGEQPVLAPGESFEYTSG 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 743522741  81 VPLATPLGVMEGSYILQDESGQRFEAPIAPFTLAVPNI 118
Cdd:COG2967   82 CVLETPVGTMQGSYQMVDEDGERFDVPIPPFSLAAPRA 119
DUF525 pfam04379
ApaG domain; The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins ...
 22-98 5.79e-44

ApaG domain; The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins and in eukaryotic F-box proteins. The domain is named after the bacterial apaG protein, of which it forms the core. The domain also occurs in the C-terminal part of eukaryotic proteins with an N-terminal F-box domain. The Salmonella typhimurium apaG domain protein corD is involved in Co(2+) resistance and Mg(2+) efflux. Tertiary structures from different apaG proteins show a fold of several beta-sheets. The apaG domain may be involved in protein-protein interactions which could be implicated in substrate-specificity.


Pssm-ID: 461283  Cd Length: 87  Bit Score: 138.37  E-value: 5.79e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 743522741   22 YHFLYRIEIENLGPGTVQLLHRRWLITDANGKMLEVEGPGVVGEQPLIAPGETFSYQSGVPLATPLGVMEGSYILQD 98
Cdd:pfam04379  11 YVFAYTIRIENLGDSSVQLLSRHWIITDANGKVEEVRGEGVVGEQPVLAPGESFEYTSGCPLETPSGSMEGSYTMVR 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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