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Conserved domains on  [gi|745759587|ref|WP_039058781|]
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SLC13 family permease [Enterobacter sp. Bisph1]

Protein Classification

SLC13 family permease( domain architecture ID 18423072)

SLC13 (solute carrier 13) family permease is a sodium-coupled symporter that facilitates the transport across biological membranes of various ions including sulfate or Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate; may function as a regulator

Gene Ontology:  GO:0008324
PubMed:  23506872|12915942|24114175

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
61-610 2.12e-55

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


:

Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 191.91  E-value: 2.12e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  61 AALFIIGDGLVRTGVATKMGAWLVNMAGSSEVKMLVLLMVTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQ-----ISPSR 135
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGsekrsKFGSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 136 LMMPLSFAGLISGMMTLVATPPNLVVNSELLREGYAGFGFFSVTPLGLVILLLGIVYMLLMRfmlrgesdaaaggswkrr 215
Cdd:COG0471   81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVL------------------ 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 216 sfrdlvkeyrlagrarrlairpgspmigqrlddlqlreryganiigverWRHFRRVIVNVNGVSEFrardvllidmsaad 295
Cdd:COG0471  143 -------------------------------------------------YRLLPPEIKEVPGSKEV-------------- 159

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 296 vdlrefcAEQQLEPMilrgeyfsdqaldvgmaevslipdseligktvreiafrtryglnvvglkrngealeGAVTDvtlq 375
Cdd:COG0471  160 -------IREELAEL--------------------------------------------------------GPLSR---- 172

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 376 lgdvflvvgnwklisqlaahgrdfvvlnlpveesaaspahsQAPHAIFCLVLMVALMLTDE---IPNPIAAIIACMLMGK 452
Cdd:COG0471  173 -----------------------------------------REKIALAIFALTVLLWITGSlhgIPIAVVALLGAVLLLL 211

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 453 FRCIDVESAYKSVHWPSIILIVGMMPFALALQKTGGVNLIVKGLMDIGGGYGPHLMLICLFVMCATIGLFISNTATAVLM 532
Cdd:COG0471  212 TGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALL 291

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 745759587 533 APIALAAAKLMGVSPYPFAMVVAMAASAAFMTPVSSPVNTLVLGPGRYQFSDFVKIGVPFTLLVMVVCVALIPVLFPF 610
Cdd:COG0471  292 LPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 303-394 3.08e-13

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


:

Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 67.25  E-value: 3.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 303 AEQQLEPMILRGEYFSDQALDVGMAEVSLIPDSELIGKTVREIAFRTRYGLNVVGLKRNGEALEGAVTDVTLQLGDVFLV 382
Cdd:COG0490   47 LLLLGELLRLLTRLLIELVLLLAIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVV 126

                         90
                 ....*....|..
gi 745759587 383 VGNWKLISQLAA 394
Cdd:COG0490  127 VGTREQLERLEE 138
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 193-289 2.71e-07

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


:

Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 49.92  E-value: 2.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 193 MLLMRFMLRGESDAAAGGSWKRRSFRDLVKEYRLAGRARRLA---IRPGSPMIGQRLDDLQLRERYGANIIGVERwrhFR 269
Cdd:COG0490   30 VLGLILRGLLLLELALLLLLLGELLRLLTRLLIELVLLLAIEevkVPPGSPLVGKTLGELNLRQRTGVTVVAIRR---GG 106

                         90       100
                 ....*....|....*....|
gi 745759587 270 RVIVNVNGVSEFRARDVLLI 289
Cdd:COG0490  107 EVILSPGPDTVLEAGDTLVV 126
 
Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
61-610 2.12e-55

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 191.91  E-value: 2.12e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  61 AALFIIGDGLVRTGVATKMGAWLVNMAGSSEVKMLVLLMVTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQ-----ISPSR 135
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGsekrsKFGSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 136 LMMPLSFAGLISGMMTLVATPPNLVVNSELLREGYAGFGFFSVTPLGLVILLLGIVYMLLMRfmlrgesdaaaggswkrr 215
Cdd:COG0471   81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVL------------------ 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 216 sfrdlvkeyrlagrarrlairpgspmigqrlddlqlreryganiigverWRHFRRVIVNVNGVSEFrardvllidmsaad 295
Cdd:COG0471  143 -------------------------------------------------YRLLPPEIKEVPGSKEV-------------- 159

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 296 vdlrefcAEQQLEPMilrgeyfsdqaldvgmaevslipdseligktvreiafrtryglnvvglkrngealeGAVTDvtlq 375
Cdd:COG0471  160 -------IREELAEL--------------------------------------------------------GPLSR---- 172

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 376 lgdvflvvgnwklisqlaahgrdfvvlnlpveesaaspahsQAPHAIFCLVLMVALMLTDE---IPNPIAAIIACMLMGK 452
Cdd:COG0471  173 -----------------------------------------REKIALAIFALTVLLWITGSlhgIPIAVVALLGAVLLLL 211

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 453 FRCIDVESAYKSVHWPSIILIVGMMPFALALQKTGGVNLIVKGLMDIGGGYGPHLMLICLFVMCATIGLFISNTATAVLM 532
Cdd:COG0471  212 TGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALL 291

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 745759587 533 APIALAAAKLMGVSPYPFAMVVAMAASAAFMTPVSSPVNTLVLGPGRYQFSDFVKIGVPFTLLVMVVCVALIPVLFPF 610
Cdd:COG0471  292 LPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 9-197 1.07e-49

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 177.01  E-value: 1.07e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587   9 LCLLGIAVVLFATGKVRMDAVALFVIVAFVLSGTLTLSEAFSGFSDPNVVLIAALFIIGDGLVRTGVATKMGAWLVNMAG 88
Cdd:cd01115    1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  89 SSEVKMLVLLMVTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQISPSRLMMPLSFAGLISGMMTLVATPPNLVVNSELLRE 168
Cdd:cd01115   81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESL 160

                        170       180
                 ....*....|....*....|....*....
gi 745759587 169 GYAGFGFFSVTPLGLVILLLGIVYMLLMR 197
Cdd:cd01115  161 GGQGFSFFEFTPIGLPLLIIGLLYLWFIF 189
CitMHS pfam03600
Citrate transporter;
16-228 1.87e-36

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 139.37  E-value: 1.87e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587   16 VVLFATGKVRMDAVALFVIVAFVLSGTLTLSEAFSGFSDPNVVLIAALFIIGDGLVRTGVATKMGAWLVNMAGSSEVKML 95
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587   96 VLLMVTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQISPSRLMMPLSFAGLISGMMTLVATPPNLVVNSeLLREGYAGFGF 175
Cdd:pfam03600  81 VALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIAS-ALGLSFGDFGF 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 745759587  176 FSVTPLGLVILLLGIVYMLLM--RFMLRGESDAAAGGSWKRRSFRDLVKEYRLAG 228
Cdd:pfam03600 160 FMFPPVGVALLLVGLLPLLLIfrKLLPVRKEEEAELEELRKRAIKDKLLLAISAL 214
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 303-394 3.08e-13

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 67.25  E-value: 3.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 303 AEQQLEPMILRGEYFSDQALDVGMAEVSLIPDSELIGKTVREIAFRTRYGLNVVGLKRNGEALEGAVTDVTLQLGDVFLV 382
Cdd:COG0490   47 LLLLGELLRLLTRLLIELVLLLAIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVV 126

                         90
                 ....*....|..
gi 745759587 383 VGNWKLISQLAA 394
Cdd:COG0490  127 VGTREQLERLEE 138
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 437-608 5.18e-12

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 68.14  E-value: 5.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  437 IPNPIAAIIACMLMGKFRCIDVESAYK-SVHWPSIILIVGMMPFALALQKTGGVNLIVKGLMDIGGGYGPH---LMLICL 512
Cdd:TIGR00785 270 INASVVALLAVVLMLFLGIVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTiavLVLVVL 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  513 FVMCATigLFISNTATAVLMAPIALAAAKLMGVSPYPFAMVVAMAA-SAAFMTPVSSPVNTLVLGPGRYQFSDFVKIGVP 591
Cdd:TIGR00785 350 FYIILY--FFASNTAHTAALVPIFFSVASAQGIPLELLALALALSAsLMGFLTPYATPPNAIAYGSGYVKIKDMWRVGAI 427

                         170
                  ....*....|....*..
gi 745759587  592 FTLLVMVVCVALIPVLF 608
Cdd:TIGR00785 428 IGIVGLIVLLLVGTLWW 444
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 326-394 2.20e-10

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 56.85  E-value: 2.20e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 745759587  326 MAEVSLIPDSELIGKTVREIAFRTRYGLNVVGLKRNGEaLEGAVTDVTLQLGDVFLVVGNWKLISQLAA 394
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGR-LIIPSGDTVLEAGDRLLVIGTPDDLAALRE 68
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 193-289 2.71e-07

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 49.92  E-value: 2.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 193 MLLMRFMLRGESDAAAGGSWKRRSFRDLVKEYRLAGRARRLA---IRPGSPMIGQRLDDLQLRERYGANIIGVERwrhFR 269
Cdd:COG0490   30 VLGLILRGLLLLELALLLLLLGELLRLLTRLLIELVLLLAIEevkVPPGSPLVGKTLGELNLRQRTGVTVVAIRR---GG 106

                         90       100
                 ....*....|....*....|
gi 745759587 270 RVIVNVNGVSEFRARDVLLI 289
Cdd:COG0490  107 EVILSPGPDTVLEAGDTLVV 126
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 231-297 2.42e-06

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 45.29  E-value: 2.42e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 745759587  231 RRLAIRPGSPMIGQRLDDLQLRERYGANIIGVERwrhfRRVIVNVNGVSEFRARDVLLIDMSAADVD 297
Cdd:pfam02080   2 VEVTVPENSPLVGKTLKELNLPERFGVRIVAIRR----GGRLIIPSGDTVLEAGDRLLVIGTPDDLA 64
 
Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
61-610 2.12e-55

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 191.91  E-value: 2.12e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  61 AALFIIGDGLVRTGVATKMGAWLVNMAGSSEVKMLVLLMVTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQ-----ISPSR 135
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGsekrsKFGSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 136 LMMPLSFAGLISGMMTLVATPPNLVVNSELLREGYAGFGFFSVTPLGLVILLLGIVYMLLMRfmlrgesdaaaggswkrr 215
Cdd:COG0471   81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVL------------------ 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 216 sfrdlvkeyrlagrarrlairpgspmigqrlddlqlreryganiigverWRHFRRVIVNVNGVSEFrardvllidmsaad 295
Cdd:COG0471  143 -------------------------------------------------YRLLPPEIKEVPGSKEV-------------- 159

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 296 vdlrefcAEQQLEPMilrgeyfsdqaldvgmaevslipdseligktvreiafrtryglnvvglkrngealeGAVTDvtlq 375
Cdd:COG0471  160 -------IREELAEL--------------------------------------------------------GPLSR---- 172

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 376 lgdvflvvgnwklisqlaahgrdfvvlnlpveesaaspahsQAPHAIFCLVLMVALMLTDE---IPNPIAAIIACMLMGK 452
Cdd:COG0471  173 -----------------------------------------REKIALAIFALTVLLWITGSlhgIPIAVVALLGAVLLLL 211

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 453 FRCIDVESAYKSVHWPSIILIVGMMPFALALQKTGGVNLIVKGLMDIGGGYGPHLMLICLFVMCATIGLFISNTATAVLM 532
Cdd:COG0471  212 TGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALL 291

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 745759587 533 APIALAAAKLMGVSPYPFAMVVAMAASAAFMTPVSSPVNTLVLGPGRYQFSDFVKIGVPFTLLVMVVCVALIPVLFPF 610
Cdd:COG0471  292 LPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 9-197 1.07e-49

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 177.01  E-value: 1.07e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587   9 LCLLGIAVVLFATGKVRMDAVALFVIVAFVLSGTLTLSEAFSGFSDPNVVLIAALFIIGDGLVRTGVATKMGAWLVNMAG 88
Cdd:cd01115    1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  89 SSEVKMLVLLMVTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQISPSRLMMPLSFAGLISGMMTLVATPPNLVVNSELLRE 168
Cdd:cd01115   81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESL 160

                        170       180
                 ....*....|....*....|....*....
gi 745759587 169 GYAGFGFFSVTPLGLVILLLGIVYMLLMR 197
Cdd:cd01115  161 GGQGFSFFEFTPIGLPLLIIGLLYLWFIF 189
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 418-608 1.58e-45

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 165.45  E-value: 1.58e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 418 APHAIFCLVLMVALMLTDEIPNPIAAIIAC---MLMGKFRCIDVESAYKSVHWPSIILIVGMMPFALALQKTGGVNLIVK 494
Cdd:cd01115  189 FRLAVLIITIVLLAALAAITGLLPVSVAIAigaIVLVFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAE 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 495 GLMDIGGGYGPHLMLICLFVMCATIGLFISNTATAVLMAPIALAAAKLMGVSPYPFAMVVAMAASAAFMTPVSSPVNTLV 574
Cdd:cd01115  269 ALISLLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIV 348

                        170       180       190
                 ....*....|....*....|....*....|....
gi 745759587 575 LGPGRYQFSDFVKIGVPFTLLVMVVCVALIPVLF 608
Cdd:cd01115  349 LGPGGYKFSDFAKVGLPLSILSLVVSVTMIPLIW 382
CitMHS pfam03600
Citrate transporter;
16-228 1.87e-36

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 139.37  E-value: 1.87e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587   16 VVLFATGKVRMDAVALFVIVAFVLSGTLTLSEAFSGFSDPNVVLIAALFIIGDGLVRTGVATKMGAWLVNMAGSSEVKML 95
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587   96 VLLMVTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQISPSRLMMPLSFAGLISGMMTLVATPPNLVVNSeLLREGYAGFGF 175
Cdd:pfam03600  81 VALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIAS-ALGLSFGDFGF 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 745759587  176 FSVTPLGLVILLLGIVYMLLM--RFMLRGESDAAAGGSWKRRSFRDLVKEYRLAG 228
Cdd:pfam03600 160 FMFPPVGVALLLVGLLPLLLIfrKLLPVRKEEEAELEELRKRAIKDKLLLAISAL 214
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 17-604 2.07e-27

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 114.65  E-value: 2.07e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  17 VLFATGKVRMDAVALFVIVAFVLSGTLTLSEAFSGFSDPNVVLIAALFIIGDGLVRTGVATKMGAWLVNMAGSSEvKMLV 96
Cdd:cd00625    2 VLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSR-RLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  97 LLMVTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQISP-SRLMMPLSFAGLISGMMTLVATPPNLVVNSEllreGYAGFGF 175
Cdd:cd00625   81 LLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSPpVPLLLALAFAANIGGAATPIGNPPNLIIASL----SGLGFLD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 176 FSvtplglvilllgiVYMLLMRFMLrgesdaaaggswkrrsfrdlvkeyrlagrarrlairpgspmigqrlddlqlrery 255
Cdd:cd00625  157 FL-------------AFMAPPALGL------------------------------------------------------- 168

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 256 ganiigverwrhfrrvivnvngvsefrardvllidmsaadvdlrefcaeqqlepmilrgeyfsdqaldvgmaevslipds 335
Cdd:cd00625      --------------------------------------------------------------------------------

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 336 eligktvreiafrtryglnvvglkrngealegavtdVTLQLGDVFLVVGNWKLISqlaahgRDFVVLNLPVEESAASPAH 415
Cdd:cd00625  169 ------------------------------------LLLLLGLLYLLFRKKLLLP------DEDKLTVLAEPLPARPLLK 206

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 416 SQAPHAIFCLVLMVALMLTDEIPNPIAAIIAC-MLMGKFRCIDVESAYKSVHWPSIILIVGMMPFALALQKTGGVNLIVK 494
Cdd:cd00625  207 KFLLLALLLLLLFVLLFFFLIPLGLIALLGALlLLLLLVRGLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAE 286

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 495 GLMDIgGGYGPHLMLICLFVMCATIGLFISNTATAVLMAPIALAAAK-----LMGVSPYPFAMVVAMAASAAFMTPVSSP 569
Cdd:cd00625  287 LLVAL-VGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLAPpepawLALALGSTLGGNLTLIGSLANLIPLGAA 365

                        570       580       590
                 ....*....|....*....|....*....|....*
gi 745759587 570 VNTLVlgpgRYQFSDFVKIGVPFTLLVMVVCVALI 604
Cdd:cd00625  366 ENAGV----GISFGEFLKVGLPLTLLSLVVSLLYL 396
CitMHS pfam03600
Citrate transporter;
392-547 4.43e-19

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 88.91  E-value: 4.43e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  392 LAAHGRDFVVLNLPVEESAASPAHSQAPHAIFCLVLMVALMLTDEIPNPIAAIIACMLMGKFRCIDVESAYKSVHWPSII 471
Cdd:pfam03600 179 LIFRKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLL 258

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 745759587  472 LIVGMMPFALALQKTGGVNLIVKGLMDIGggyGPHLMLICLFVMCATIGLFISNTATAVLMAPIALAAAKLMGVSP 547
Cdd:pfam03600 259 FFAGLFILVGALEKTGLADALADALGGLS---GLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGD 331
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
1-161 1.94e-18

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 87.52  E-value: 1.94e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587   1 MNGELIWVLCLLGIAVVLFATG---KVRMDAVALFVIVAFVLSGTLTLSEAFSGFSDPNVVLIAALFIIGDGLVRTGVAT 77
Cdd:COG0471  170 LSRREKIALAIFALTVLLWITGslhGIPIAVVALLGAVLLLLTGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAA 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  78 KMGAWLVN-MAGSSEVKMLVLLMVTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQISPSRLMMPLSFAGLiSGMMTLVATP 156
Cdd:COG0471  250 WLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAAS-CAFLLPVGTP 328


                 ....*
gi 745759587 157 PNLVV 161
Cdd:COG0471  329 PNAIV 333
CitMHS pfam03600
Citrate transporter;
429-608 2.55e-17

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 83.52  E-value: 2.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  429 VALMLTDEIPNPIAAIIACMLMGKFRCIDVESAYKSVHWPSIILIVGMMPFALALQKTGGVNLIVKGLMDIGGGYgPHLM 508
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGK-PRRL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  509 LICLFVMCATIGLFISNTATAVLMAPIALAAAKLMGVSPYPFAMVVAMAASAAF-MTPVSSPVNTLVLGPGRYQFSDFVK 587
Cdd:pfam03600  80 LVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGtATPIGDPPNIIIASALGLSFGDFGF 159

                         170       180
                  ....*....|....*....|.
gi 745759587  588 IGVPFTLLVMVVCVALIPVLF 608
Cdd:pfam03600 160 FMFPPVGVALLLVGLLPLLLI 180
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 430-610 5.43e-15

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 77.29  E-value: 5.43e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 430 ALMLTDEIPNPIAAIIACMLMGKFRCIDVESAYKSVHWPSIILIVGMMPFALALQKTGGVNLIVKGLMDIGGGYGPHLML 509
Cdd:cd00625    2 VLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRLLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 510 ICLFVmcATIGLFISNTATAVLMAPIALAAAKLMGVSPYPFAMVVAMAASAA--FMTPVSSPVNTLVLGPGRYQFSDFVK 587
Cdd:cd00625   82 LMLLT--AALSAFFSNDATAVLLTPIVLALLRKLGLSPPVPLLLALAFAANIggAATPIGNPPNLIIASLSGLGFLDFLA 159

                        170       180
                 ....*....|....*....|...
gi 745759587 588 IGVPFTLLVMVVCVALIPVLFPF 610
Cdd:cd00625  160 FMAPPALGLLLLLLGLLYLLFRK 182
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
421-609 9.35e-15

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 76.71  E-value: 9.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 421 AIFCLVLMVALMLTDEIPNPIAAIIACMLMGKFRCIDVESAYKSVHWPSIILIVGMMPFALALQKTGGVNLIVKGLMDIG 500
Cdd:COG1055    7 AIFVLTYLLIILEPRGLNRAVAALLGAALLLLLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 501 GGyGPHLMLICLFVMCATIGLFISNTATAVLMAPIALAAAKLMGVSPYPFAMVVAMAA-SAAFMTPVSSPVNTLVLGPGR 579
Cdd:COG1055   87 KG-SPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAAnIGGAATPIGNPTNIMIASAGG 165

                        170       180       190
                 ....*....|....*....|....*....|
gi 745759587 580 YQFSDFVKIGVPFTLLVMVVCVALIPVLFP 609
Cdd:COG1055  166 LSFLDFLANLFPPSLVSLLVTLLVLYLLFR 195
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
6-161 3.24e-14

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 74.78  E-value: 3.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587   6 IWVLCLLGIAVVLFATGKVRMD--AVALFVIVAFVLSGTLTLSEAFSGFSDPNVVLIAALFIIGDGLVRTGVATKMGAWL 83
Cdd:COG1055    3 ILALAIFVLTYLLIILEPRGLNraVAALLGAALLLLLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKL 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 745759587  84 VNMAGSSEVKMLVLLMVTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQISPSRLMMPLSFAGLISGMMTLVATPPNLVV 161
Cdd:COG1055   83 ARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGGAATPIGNPTNIMI 160
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 303-394 3.08e-13

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 67.25  E-value: 3.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 303 AEQQLEPMILRGEYFSDQALDVGMAEVSLIPDSELIGKTVREIAFRTRYGLNVVGLKRNGEALEGAVTDVTLQLGDVFLV 382
Cdd:COG0490   47 LLLLGELLRLLTRLLIELVLLLAIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVV 126

                         90
                 ....*....|..
gi 745759587 383 VGNWKLISQLAA 394
Cdd:COG0490  127 VGTREQLERLEE 138
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 425-598 2.71e-12

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 68.77  E-value: 2.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 425 LVLMVALMLTDEIPNPIAAIIACMLMGKFRCIDVESAYKSVHWPSIILIVGMMPFALALQKTGGVNLIVKGLMDIGGGyG 504
Cdd:cd01115    4 LVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGK-G 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 505 PHLMLICLFVMCATIGLFISNTATAVLMAPIALAAAKLMGVSPYP-FAMVVAMAASAAFMTPVSSPVNTLV------LGP 577
Cdd:cd01115   83 ERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRlLMPLAFAASIGGMLTLIGTPPNLVAsgylesLGG 162

                        170       180
                 ....*....|....*....|.
gi 745759587 578 GRYQFSDFVKIGVPFTLLVMV 598
Cdd:cd01115  163 QGFSFFEFTPIGLPLLIIGLL 183
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 11-161 2.96e-12

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 68.77  E-value: 2.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  11 LLGIAVVLFATGKVRMDAVALFVIVAFVLSGTLTLSEAFSGFSDPNVVLIAALFIIGDGLVRTGVATKMGAWLVNMAGSS 90
Cdd:cd01115  198 IVLLAALAAITGLLPVSVAIAIGAIVLVFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISLLGGL 277

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 745759587  91 EV-KMLVLLMVTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQISPSRLMMPLSFAGlISGMMTLVATPPNLVV 161
Cdd:cd01115  278 PPfAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGA-SCAFMLPVGTPPNAIV 348
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 437-608 5.18e-12

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 68.14  E-value: 5.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  437 IPNPIAAIIACMLMGKFRCIDVESAYK-SVHWPSIILIVGMMPFALALQKTGGVNLIVKGLMDIGGGYGPH---LMLICL 512
Cdd:TIGR00785 270 INASVVALLAVVLMLFLGIVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTiavLVLVVL 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  513 FVMCATigLFISNTATAVLMAPIALAAAKLMGVSPYPFAMVVAMAA-SAAFMTPVSSPVNTLVLGPGRYQFSDFVKIGVP 591
Cdd:TIGR00785 350 FYIILY--FFASNTAHTAALVPIFFSVASAQGIPLELLALALALSAsLMGFLTPYATPPNAIAYGSGYVKIKDMWRVGAI 427

                         170
                  ....*....|....*..
gi 745759587  592 FTLLVMVVCVALIPVLF 608
Cdd:TIGR00785 428 IGIVGLIVLLLVGTLWW 444
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 9-177 8.48e-12

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 67.37  E-value: 8.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587    9 LCLLGIAVVLFATGKVRMDAVALFVI-VAFVLSGTLTL---SEAFSGFSDPNVVLIAALFIIGDGLVRTGVATKMGAWLV 84
Cdd:TIGR00785  14 LAIFVAAIVGWILEPLPLPVTALLAIpIIAVLLGVLSAfkfKNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLV 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587   85 NMAGSSEVKMLVLLMVTVAGLGAF-MSSTGVV-AIFIPVVLSVSMRMQISPSR--------LMMPLSFAGLISGMMTLVA 154
Cdd:TIGR00785  94 GKMGGTTLGLGYFLVFLETLLAPMwPSNTARAgGILLPIIKSLLPLLGSKPEKsprkigkyLMLGIAYSASIGSSGFLTG 173

                         170       180
                  ....*....|....*....|...
gi 745759587  155 TPPNLVVNSELLREGYAGFGFFS 177
Cdd:TIGR00785 174 SAPNALAAGILSKILGIQISWGD 196
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 11-161 4.64e-11

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 65.06  E-value: 4.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587   11 LLGIAVVLFATGK---VRMDAVALFVIVAFVLSGTLTLSEAFSGFSDPNV-VLIAALFIIGDGLVRTGVATKMGAWLVNM 86
Cdd:TIGR00785 254 IFLLALLLWIFGGslgINASVVALLAVVLMLFLGIVTWKDIQKNKVAWNTlILFGGLIGLAGGLKKSGFIKWFSEKLVGI 333

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 745759587   87 AG--SSEVKMLVLLMVTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQISPSRLMMPLSFAGLISGMMTLVATPPNLVV 161
Cdd:TIGR00785 334 LDglSPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMGFLTPYATPPNAIA 410
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 5-161 7.45e-11

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 64.19  E-value: 7.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587   5 LIWVLCLLGIAVVLFATGKVRMDAVALFVIVAFVLSGTLTLSEAFSGFSDPNVVLIAALFIIGDGLVRTGVATKMGAWLV 84
Cdd:cd00625  210 LLALLLLLLFVLLFFFLIPLGLIALLGALLLLLLLVRGLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLV 289

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 745759587  85 NMAGSSEVKMLVLLMVTVAGLGAFMSSTGVVAIFIPVVLSVSmrmqiSPSRLMMPLSFAGLISGMMTLVATPPNLVV 161
Cdd:cd00625  290 ALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLA-----PPEPAWLALALGSTLGGNLTLIGSLANLIP 361
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 326-394 2.20e-10

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 56.85  E-value: 2.20e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 745759587  326 MAEVSLIPDSELIGKTVREIAFRTRYGLNVVGLKRNGEaLEGAVTDVTLQLGDVFLVVGNWKLISQLAA 394
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGR-LIIPSGDTVLEAGDRLLVIGTPDDLAALRE 68
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 425-608 1.07e-09

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 60.73  E-value: 1.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 425 LVLMVALMLTDEIPNPIAAII--ACMLMGKFRCI--DVESAYKSVHWPSIILIVGMMPFALALQKTGGVNLIVKGLMDIG 500
Cdd:cd01116    1 FIITYALIIFEKVHRTVAALAgaLWLVILGLATLspDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKIS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 501 GGYgPHLMLICLFVMCATIGLFISNTATAVLMAPIALAAAKLMGVSPYPFAMVVAMAASAAFM-TPVSSPVNTLVLGPGR 579
Cdd:cd01116   81 KGR-PWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAaTLIGDPPNIMIGSAAG 159

                        170       180
                 ....*....|....*....|....*....
gi 745759587 580 YQFSDFVKIGVPFTLLVMVVCVALIPVLF 608
Cdd:cd01116  160 LTFNDFLLHMLPSVVLALVVTFILLYFLY 188
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 18-164 1.13e-09

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 60.75  E-value: 1.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  18 LFATGKVRMD--AVALFVIVAFVLSGTLTLSEAFSGFSDPNVVLIAALFIIGDGLVRTGVATKMGAWLVNMAGSSEvKML 95
Cdd:cd01117    3 LGRVPGLRLDrwAIALLGAALMLLFGVISLEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRILVKAGSPR-RLL 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 745759587  96 VLLMVTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQISPSRLMMPLSFAGLISGMMTLVATPPNLVVNSE 164
Cdd:cd01117   82 FLLVLLSGILSALLTNDTACLVFTPIVLELARVAGLPPIPLLLALATAANIGSAATPIGNPQNLLIASE 150
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 416-609 3.80e-08

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 55.81  E-value: 3.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  416 SQAPHAIFCLVLMVALMLTDEIPNPIAAIIACMLM----GKFRCIDVESAYKSVHWPSIILIVGMMPFALALQKTGGVNL 491
Cdd:TIGR00785   8 SGAWLLLAIFVAAIVGWILEPLPLPVTALLAIPIIavllGVLSAFKFKNALSGFADPTIWLFFGAFILATALVKTGLGKR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  492 IVKGLMDIGGGYGPHLMLICLFVMCATIGLFISNTA-TAVLMAPIALAAAKLMGVSP---------YPFAMVVAMAASAA 561
Cdd:TIGR00785  88 IAYKLVGKMGGTTLGLGYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLLGSKPeksprkigkYLMLGIAYSASIGS 167

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 745759587  562 FMTPVSSPVNTLVLG------PGRYQFSDFVKIGVPFTLLVMVVCVALIPVLFP 609
Cdd:TIGR00785 168 SGFLTGSAPNALAAGilskilGIQISWGDWFLAGLPLGIILLLLVPLLLYVLFP 221
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 443-610 6.73e-08

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 54.98  E-value: 6.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 443 AIIACMLMGKFRCIDVESAYKSVHWPSIILIVGMMPFALALQKTGGVNLIVKGLMDIGGgyGPHLMLICLFVMCATIGLF 522
Cdd:cd01117   17 ALLGAALMLLFGVISLEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRILVKAG--SPRRLLFLLVLLSGILSAL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 523 ISNTATAVLMAPIALAAAKLMGVSPYPFAMVVAMAASA-AFMTPVSSPVNTLVLGPGRYQFSDFVKIGVPFTLLVMVVCV 601
Cdd:cd01117   95 LTNDTACLVFTPIVLELARVAGLPPIPLLLALATAANIgSAATPIGNPQNLLIASESGISFPFFLAAMAPLALLGLLLLL 174


                 ....*....
gi 745759587 602 ALIPVLFPF 610
Cdd:cd01117  175 ILLLVLFPG 183
CitMHS pfam03600
Citrate transporter;
7-133 1.30e-07

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 53.86  E-value: 1.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587    7 WVLCLLGIAVVLFATGKVRMDAVALFVIVAFVLSGTLTLSEAFSGFSDPNVVLIAALFIIGDGLVRTGVATKMGAWLVNM 86
Cdd:pfam03600 207 LLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGL 286

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 745759587   87 AGSseVKMLVLLMVTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQISP 133
Cdd:pfam03600 287 SGL--LVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGD 331
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 193-289 2.71e-07

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 49.92  E-value: 2.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 193 MLLMRFMLRGESDAAAGGSWKRRSFRDLVKEYRLAGRARRLA---IRPGSPMIGQRLDDLQLRERYGANIIGVERwrhFR 269
Cdd:COG0490   30 VLGLILRGLLLLELALLLLLLGELLRLLTRLLIELVLLLAIEevkVPPGSPLVGKTLGELNLRQRTGVTVVAIRR---GG 106

                         90       100
                 ....*....|....*....|
gi 745759587 270 RVIVNVNGVSEFRARDVLLI 289
Cdd:COG0490  107 EVILSPGPDTVLEAGDTLVV 126
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
6-177 5.51e-07

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 52.05  E-value: 5.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587   6 IWVLCLLGIAVVLFATGKVRMDAVALFVIVAFVLSGTLTLSEAFSGFSDPNVVLIAALFIIGDGLVRTGVATKMGAWLVN 85
Cdd:COG1055  222 LLVLALLLVGFVLHSFLGLPPALIALLGAAVLLLLARVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLAS 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  86 MAGSSEVKMLVLLMVTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQISPsrLMMPLSFAGLISGMMTLVATPPNLVVnSEL 165
Cdd:COG1055  302 LTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLGATGNPEP--LWLALALGATLGGNLTPIGSAANVIV-LGI 378

                        170
                 ....*....|..
gi 745759587 166 LREGYAGFGFFS 177
Cdd:COG1055  379 AEKKGIKISFGE 390
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 231-297 2.42e-06

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 45.29  E-value: 2.42e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 745759587  231 RRLAIRPGSPMIGQRLDDLQLRERYGANIIGVERwrhfRRVIVNVNGVSEFRARDVLLIDMSAADVD 297
Cdd:pfam02080   2 VEVTVPENSPLVGKTLKELNLPERFGVRIVAIRR----GGRLIIPSGDTVLEAGDRLLVIGTPDDLA 64
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 5-170 2.43e-06

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 50.33  E-value: 2.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587   5 LIWVLCLLGIAVVLFATG---KVRMDAVALF-VIVAFVLSGTLTLSEAFSGFSDPNVVLIAALFIIGDGLVRTGVATKMG 80
Cdd:cd01116  217 LLKSLTILTLVIIGFVLHsplGVSLGWIALLgALLLLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIA 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  81 AWLVNMAGSSEVKMLVLLMVTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQISPSRLMMPLSFAGLISGMMTLVATPPNLV 160
Cdd:cd01116  297 ELLVGVILGRIAVAVILILWISALLSAFIDNIPVTATMIPIVKDLASQLGIPLLPLWWALALGACLGGNGTLIGASANVV 376

                        170
                 ....*....|
gi 745759587 161 VNSELLREGY 170
Cdd:cd01116  377 AAGIAEQHGY 386
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 315-379 3.07e-06

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 49.29  E-value: 3.07e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 745759587 315 EYFSDQALDVGMAEVSLIPDSELIGKTVREIAFRTRYGLNVVGLKRNGEALeGAVTDVTLQLGDV 379
Cdd:COG0569  231 DVLELADGDAEIVEVTVPEGSPLVGKTLKELDLRERYGVTVVAIKRGGEVI-IPSGDTVLEAGDE 294
COG3273 COG3273
Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];
323-386 4.14e-06

Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];


Pssm-ID: 442504 [Multi-domain]  Cd Length: 387  Bit Score: 49.28  E-value: 4.14e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 745759587 323 DVGMAEVSLIPDSELIGKTVREIAFRTRYGLNVVGLKRNGEALEGAVTDVTLQLGDVFLVVGNW 386
Cdd:COG3273  312 DERIVRVTVPPGSPLVGKTLGELKLETETGVRVIAIRRGGGWIYDPDGDTRLRAGDVLIVKGTR 375
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 15-160 1.30e-05

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 48.14  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587   15 AVVLFATGKVRMDAVALFVIVAF-VLSGTLT---LSEAFSGFSDPNVVLIAALFIIGDGLVRTGVATKMGAWLVNMAGSS 90
Cdd:pfam00939  40 TIVGWILEPLPMAVIALFAISLSaILIGTLLakaLSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKR 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587   91 EVKMLVLLMVTVAGLGAFMSSTGV--VAIFIPVVLSVSMRMQISP---------SRLMMPLSFAGLISGMMTLVATPPNL 159
Cdd:pfam00939 120 TLGLGYGLVFSDLLLAPATPSNTAraGGIVFPIIMSLPPAFGSDPekgserrigAYLMWTVYQSTSITSAMFLTAMAPNL 199


                  .
gi 745759587  160 V 160
Cdd:pfam00939 200 L 200
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 28-163 2.67e-05

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 46.86  E-value: 2.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  28 AVALFVIVAFVLSGTLTLSEAFSgFSDPNVV-LIAALFIIGDGLVRTGVATKMGAWLVNMAGSSEVKMLVLLMVTVAGLG 106
Cdd:cd01116   21 AGALWLVILGLATLSPDLETIVS-WVDWETLaLLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLS 99

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 745759587 107 AFMSSTGVVAIFIPVVLSVSMRMQISPSRLMMPLSFAGLISGMMTLVATPPNLVVNS 163
Cdd:cd01116  100 AFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGS 156
DctM pfam06808
Tripartite ATP-independent periplasmic transporter, DctM component; This family contains a ...
 28-157 3.88e-05

Tripartite ATP-independent periplasmic transporter, DctM component; This family contains a diverse range of predicted transporter proteins. Including the DctM subunit of the bacterial and archaeal TRAP C4-dicarboxylate transport (Dct) system permease. In general, C4-dicarboxylate transport systems allow C4-dicarboxylates like succinate, fumarate, and malate to be taken up. TRAP C4-dicarboxylate carriers are secondary carriers that use an electrochemical H+ gradient as the driving force for transport. DctM is an integral membrane protein that is one of the constituents of TRAP carriers. Note that many family members are hypothetical proteins.


Pssm-ID: 284275 [Multi-domain]  Cd Length: 413  Bit Score: 46.48  E-value: 3.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587   28 AVALFVIVAFVLSGTLTLSEAFSGFSDPNVVLIAALFIIGDGLV------RTGVATKMGAWLVNMAGSSEVkMLVLLMVT 101
Cdd:pfam06808 241 AVVYALLIGVLVYRRLTLEEVAAALLQTAKTTAAVLFILAAAGIfaglltITGVPFKLSDWLLSLGGGNLL-FLILVNLL 319

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 745759587  102 VAGLGAFMSSTGVVAIFIPVVLSVSMRMQISPSRLMMPLSFAGLISGMmtlvaTPP 157
Cdd:pfam06808 320 CLVLGMFLDPTAAIIILVPILAPAAAQLGIDPIHFGVVIVYNGSIGLI-----TPP 370
COG3273 COG3273
Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];
69-289 5.62e-05

Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];


Pssm-ID: 442504 [Multi-domain]  Cd Length: 387  Bit Score: 45.81  E-value: 5.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  69 GLVRTGVATKMGAWLVNMAGSSEVKM--LVLLMVTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQISPSRLMMPLSFAGLI 146
Cdd:COG3273  150 TGVRVIAIRRGDDWLLNPGPTTILRAddLVLLRGPEGGILEVYLAATGDLYERPRPPEDSIVEMKNLSELAVDLAYSSVL 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 147 SGMMTLVATPPNLVVNSELLREGYAGFGFFSVTPLGLVILLLGivyMLLMRFMLRGESDAAAGGSWKRrsFRDLVKEYRL 226
Cdd:COG3273  230 FDSEELAEEVRELEEEVDALKSRLEAWVLRAARRVDDPVALRG---LLHLASSTEVISDAALDIAEGV--LRGLEDHPVV 304

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 227 AG-------RARRLAIRPGSPMIGQRLDDLQLRERYGANIIGVerwRHFRRVIVNVNGVSEFRARDVLLI 289
Cdd:COG3273  305 AEavresdeRIVRVTVPPGSPLVGKTLGELKLETETGVRVIAI---RRGGGWIYDPDGDTRLRAGDVLIV 371
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 14-178 5.72e-05

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 45.83  E-value: 5.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587   14 IAVVLFATG-KVRMDA--VALFVIVAFVLSGTLTLSEAFSGFSDPN-VVLIAALFIIGDGLVRTGVATKMGAWLVNM--A 87
Cdd:pfam00939 278 LLLLLWIFGgSLNIDAttVAIIGLALMLLLRILDWKDIVKNKGAWNtLIWLGGLIMLANGLERSGFIEWLGNTLSTSlsG 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587   88 GSSEVKMLVLLMVTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQ-ISPSRLMMPLSFAGLISGMMTLVATPPNLVvnsell 166
Cdd:pfam00939 358 FSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIPgAPPLLAALLLGFAISLGGFLTPYGTGPGPI------ 431

                         170
                  ....*....|..
gi 745759587  167 regYAGFGFFSV 178
Cdd:pfam00939 432 ---YFGSGYLKV 440
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
422-604 6.03e-05

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 45.89  E-value: 6.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 422 IFCLVLMVALMLTDEIPNPIA--AIIACMLMGKFRCIDVESAYKSVHWPSIILIVGMMPFALALQKTGGVNLIVKGLMDI 499
Cdd:COG1055  223 LVLALLLVGFVLHSFLGLPPAliALLGAAVLLLLARVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASL 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 500 GGGYGPHLMLICLFVMcATIGLFISNTATAVLMAPIAlaaaKLMGVSPYPFAMVVAMAASAAF---MTPVSSPVNTLVLG 576
Cdd:COG1055  303 TGGNLLLAALLILWLS-AILSAVVDNVPLVAALLPLI----PDLGATGNPEPLWLALALGATLggnLTPIGSAANVIVLG 377

                        170       180       190
                 ....*....|....*....|....*....|...
gi 745759587 577 -----PGRYQFSDFVKIGVPFTLLVMVVCVALI 604
Cdd:COG1055  378 iaekkGIKISFGEFLKVGLPLTLLTLLIALLYL 410
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 193-394 1.01e-04

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 45.11  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 193 MLLMRFMLRGESDAAAggswKRRSFRDLVKEYRLAGRARRLAirpGSPMIGQRLDDLqlRERYGANIIgVERWRHFRRVI 272
Cdd:COG2985  173 VALLPKLFRIDLDAEA----KKLEAGEGSAYPPLVTRAYRVT---NPNLVGKTVAEL--EALLGTRVV-ISRIRRGGEII 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 273 VnVNGVSEFRARDVLLIDMSAADVDlrefcaeqqlEPMILRG-EYFSDQALDVGMAEVS-LIPDSELIGKTVREIAFRTR 350
Cdd:COG2985  243 V-PTPDTVLQEGDIVLVVGTREALE----------AAEALLGeEVDDSELLDSDLDVRRiVVTNKEVAGKTLGELNLRNR 311

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 745759587 351 YGLNVVGLKRNGEALeGAVTDVTLQLGDVFLVVGNWKLISQLAA 394
Cdd:COG2985  312 FGVVITRVRRGGVEL-PATPDTVLQLGDRLTVVGPKEDVERVAK 354
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 229-288 1.89e-04

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 43.90  E-value: 1.89e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 229 RARRLAIRPGSPMIGQRLDDLQLRERYGANIIGVERwrhfRRVIVNVNGVSEFRARDVLL 288
Cdd:COG0569  241 EIVEVTVPEGSPLVGKTLKELDLRERYGVTVVAIKR----GGEVIIPSGDTVLEAGDELI 296
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 467-604 3.15e-04

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 43.51  E-value: 3.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  467 WPSIILIVGMMPFALALQKTGGVNLIVKGLMDIGGGYGPHL-MLICLFVMCATIGLFISNTATAVLMAPIALAAAKLMGV 545
Cdd:pfam00939 322 WNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMaFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIPG 401

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 745759587  546 SPYPFAMVVAMAAS--AAFMTPVSSPVNTLVLGPGRYQFSDFVKIGVPFTLLVMVVCVALI 604
Cdd:pfam00939 402 APPLLAALLLGFAIslGGFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLG 462
GntT COG2610
H+/gluconate symporter GntT or related permease, GntP/DsdX family [Carbohydrate transport and ...
 7-156 2.08e-03

H+/gluconate symporter GntT or related permease, GntP/DsdX family [Carbohydrate transport and metabolism];


Pssm-ID: 442022 [Multi-domain]  Cd Length: 440  Bit Score: 40.87  E-value: 2.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587   7 WVLCLLGIAVVLFATGKVRMDAVALFVIVAFV---LSG------TLTLSEAFSGFSDPNVVLIAALFIIGDGLVRTGVAT 77
Cdd:COG2610    4 LLGLLLAIALLILLIIKFKLHPFLALLLAALLvglLAGmplakiVTSIMTGFGGTLGSIGLVIGLGAMLGKLLEDSGAAE 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 745759587  78 KMGAWLVNMAGSSEVKMLVLLMVTVAGLGAFMSStgVVAIFIPVVLSVSMRMQISPSRLMMPLSfAGLISGMMTLVATP 156
Cdd:COG2610   84 RIADTIIKKFGEKRAPLALVLAGFILGIPVFFDV--GFVILAPLAFSLARRAGISKLLIGLALA-AGLSTTHMLVPPTP 159
DctM pfam06808
Tripartite ATP-independent periplasmic transporter, DctM component; This family contains a ...
 504-610 2.90e-03

Tripartite ATP-independent periplasmic transporter, DctM component; This family contains a diverse range of predicted transporter proteins. Including the DctM subunit of the bacterial and archaeal TRAP C4-dicarboxylate transport (Dct) system permease. In general, C4-dicarboxylate transport systems allow C4-dicarboxylates like succinate, fumarate, and malate to be taken up. TRAP C4-dicarboxylate carriers are secondary carriers that use an electrochemical H+ gradient as the driving force for transport. DctM is an integral membrane protein that is one of the constituents of TRAP carriers. Note that many family members are hypothetical proteins.


Pssm-ID: 284275 [Multi-domain]  Cd Length: 413  Bit Score: 40.32  E-value: 2.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587  504 GPHLMLICLFVMCATIGLFISNTATAVLMAPIALAAAKLMGVSPYPFAMVVAMAASAAFMTPVSSPVNTLVLGPGRYQFS 583
Cdd:pfam06808 308 GNLLFLILVNLLCLVLGMFLDPTAAIIILVPILAPAAAQLGIDPIHFGVVIVYNGSIGLITPPVGLALFVAAGIAKVSFE 387

                          90       100
                  ....*....|....*....|....*..
gi 745759587  584 DFVKIGVPFtLLVMVVCVALIPVLFPF 610
Cdd:pfam06808 388 EVVKGVVPF-LFVLVPALVLIISVPEL 413
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 467-608 3.65e-03

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 39.94  E-value: 3.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745759587 467 WPSIILIVGMMPFALALQKTGGVNLIVKGLMDIGGGyGPHLMLICLFVMCATIGLFISNTATAVLMAPIALAAAKLMGVS 546
Cdd:cd01118   52 WDVTLTLIGVILLSLLLDEEGFFEWVAALAARWARG-SGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAK 130

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 745759587 547 PY---PFAMVVAMAA-SAAFMTPVSSPVNTLVLGPGRYQFSDFVKIGVPFTLLVMVVCVALIPVLF 608
Cdd:cd01118  131 KNrtlPFLYACAFIAdAASLPLPISNLVNIVTAGYFGIGFTEYAALMFLPSIVSILATYVVLYLFF 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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