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Conserved domains on  [gi|746090242|ref|WP_039156961|]
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MULTISPECIES: ribonuclease III [Lactobacillus]

Protein Classification

ribonuclease III family protein( domain architecture ID 11426290)

ribonuclease III family protein similar to ribonuclease III, which digests double-stranded RNA in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S)

CATH:  1.10.1520.10
EC:  3.1.26.3
Gene Ontology:  GO:0004525|GO:0006396
PubMed:  18047582|24124076|17194582
SCOP:  4002876

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Rnc COG0571
dsRNA-specific ribonuclease [Transcription];
10-211 2.42e-90

dsRNA-specific ribonuclease [Transcription];


:

Pssm-ID: 440336 [Multi-domain]  Cd Length: 229  Bit Score: 265.04  E-value: 2.42e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090242  10 LKEKYGIKFNNENLLEDAFTHSSYANEHPGRKDYEKLEFLGDAVLELAVSDYLYRHFPRLNEGELTRMRSNIVRTEGFSE 89
Cdd:COG0571    7 LEERLGYRFKDPELLEQALTHRSYANEHGGLENNERLEFLGDAVLGLVVAEYLYRRFPDAPEGELSKLRAALVSEETLAE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090242  90 FAIECGFPAEINLGKGEEKAGARKRKTLLEDVFEAFNGALFLDQGMPAVQHFLHLTVYPLIAEGDF-NASRDYKTELQER 168
Cdd:COG0571   87 IARELGLGDYLRLGKGEEKSGGRRRPSILADAFEALIGAIYLDGGLEAARKFVLRLFEPRLEEIAPgGAGKDYKTALQEW 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 746090242 169 LQVNGPVKIEYQVIAED--ESKPSFKVQLLVNDKKISEGQGRNKK 211
Cdd:COG0571  167 LQARGLPLPEYEVVEEEgpDHAKTFTVEVLVGGKVLGEGTGRSKK 211
 
Name Accession Description Interval E-value
Rnc COG0571
dsRNA-specific ribonuclease [Transcription];
10-211 2.42e-90

dsRNA-specific ribonuclease [Transcription];


Pssm-ID: 440336 [Multi-domain]  Cd Length: 229  Bit Score: 265.04  E-value: 2.42e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090242  10 LKEKYGIKFNNENLLEDAFTHSSYANEHPGRKDYEKLEFLGDAVLELAVSDYLYRHFPRLNEGELTRMRSNIVRTEGFSE 89
Cdd:COG0571    7 LEERLGYRFKDPELLEQALTHRSYANEHGGLENNERLEFLGDAVLGLVVAEYLYRRFPDAPEGELSKLRAALVSEETLAE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090242  90 FAIECGFPAEINLGKGEEKAGARKRKTLLEDVFEAFNGALFLDQGMPAVQHFLHLTVYPLIAEGDF-NASRDYKTELQER 168
Cdd:COG0571   87 IARELGLGDYLRLGKGEEKSGGRRRPSILADAFEALIGAIYLDGGLEAARKFVLRLFEPRLEEIAPgGAGKDYKTALQEW 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 746090242 169 LQVNGPVKIEYQVIAED--ESKPSFKVQLLVNDKKISEGQGRNKK 211
Cdd:COG0571  167 LQARGLPLPEYEVVEEEgpDHAKTFTVEVLVGGKVLGEGTGRSKK 211
RNaseIII TIGR02191
ribonuclease III, bacterial; This family consists of bacterial examples of ribonuclease III. ...
 10-211 2.88e-85

ribonuclease III, bacterial; This family consists of bacterial examples of ribonuclease III. This enzyme cleaves double-stranded rRNA. It is involved in processing ribosomal RNA precursors. It is found even in minimal genones such as Mycoplasma genitalium and Buchnera aphidicola, and in some cases has been shown to be an essential gene. These bacterial proteins contain a double-stranded RNA binding motif (pfam00035) and a ribonuclease III domain (pfam00636). Eukaryotic homologs tend to be much longer proteins with additional domains, localized to the nucleus, and not included in this family. [Transcription, RNA processing]


Pssm-ID: 274024 [Multi-domain]  Cd Length: 220  Bit Score: 252.12  E-value: 2.88e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090242   10 LKEKYGIKFNNENLLEDAFTHSSYANE-HPGRKDYEKLEFLGDAVLELAVSDYLYRHFPRLNEGELTRMRSNIVRTEGFS 88
Cdd:TIGR02191   1 LEKRLGYKFKNPELLEQALTHRSYANEhHKDVKNNERLEFLGDAVLGLVVAEYLFKNFPDASEGELSRLRAALVSEESLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090242   89 EFAIECGFPAEINLGKGEEKAGARKRKTLLEDVFEAFNGALFLDQGMPAVQHFLHLTVYPLIAEGD-FNASRDYKTELQE 167
Cdd:TIGR02191  81 EVARELGLGDFLLLGKGEEKSGGRRRDSILADAFEALIGAIYLDSGLEAARKFILKLLIPRIDAIIkEETLKDYKTALQE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 746090242  168 RLQVNGPVKIEYQVIAED--ESKPSFKVQLLVNDKKISEGQGRNKK 211
Cdd:TIGR02191 161 WAQARGKPLPEYRLIKEEgpDHDKEFTVEVSVNGEPYGEGKGKSKK 206
RIBOc cd00593
RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and ...
 23-154 5.08e-54

RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional control of mRNA stability and translational efficiency. It is involved in the processing of ribosomal RNA precursors. Prokaryotic RNAse III also plays a role in the maturation of tRNA precursors and in the processing of phage and plasmid transcripts. Eukaryotic RNase III's participate (through direct cleavage) in rRNA processing, in processing of small nucleolar RNAs (snoRNAs) and snRNA's (components of the spliceosome). In eukaryotes RNase III or RNaseIII like enzymes such as Dicer are involved in RNAi (RNA interference) and miRNA (micro-RNA) gene silencing.


Pssm-ID: 238333  Cd Length: 133  Bit Score: 169.72  E-value: 5.08e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090242  23 LLEDAFTHSSYANEHPgRKDYEKLEFLGDAVLELAVSDYLYRHFPRLNEGELTRMRSNIVRTEGFSEFAIECGFPAEINL 102
Cdd:cd00593    2 LLLEALTHPSYANEHG-RFNNERLEFLGDAVLELVVTEYLFKKFPDLSEGDLTRLRSALVSNETLARLARELGLGKYLRL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 746090242 103 GKGEEKAGARKRKTLLEDVFEAFNGALFLDQGMPAVQHFLHLTVYPLIAEGD 154
Cdd:cd00593   81 GKGEEKSGGRLRPKILADVFEALIGAIYLDGGFEAARKFLLRLLGPLIEEIS 132
RIBOc smart00535
Ribonuclease III family;
22-152 5.08e-49

Ribonuclease III family;


Pssm-ID: 197778  Cd Length: 129  Bit Score: 156.61  E-value: 5.08e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090242    22 NLLEDAFTHSSYANEHPgrkDYEKLEFLGDAVLELAVSDYLYRHFPRLNEGELTRMRSNIVRTEGFSEFAIECGFPAEIN 101
Cdd:smart00535   1 SLLLRALTHASYSNEHE---HNERLEFLGDAVLELVVTEYLYKKYPDLSEGDLSRLRSALVSNETLARLAKKLGLGEFIR 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 746090242   102 LGKGEEKAGARKRKTLLEDVFEAFNGALFLDQGMPAVQHFLHLTVYPLIAE 152
Cdd:smart00535  78 LGRGEAISGGRDKPKILADVFEALIGAIYLDSGLEAAREFIRDLLGPRLDE 128
Ribonucleas_3_3 pfam14622
Ribonuclease-III-like; Members of this family are involved in rDNA transcription and rRNA ...
 21-143 1.27e-36

Ribonuclease-III-like; Members of this family are involved in rDNA transcription and rRNA processing. They probably also cleave a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end; they are involved in polyadenylation-independent transcription termination. Some members may be mitochondrial ribosomal protein subunit L15, others may be 60S ribosomal protein L3.


Pssm-ID: 434075  Cd Length: 127  Bit Score: 124.98  E-value: 1.27e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090242   21 ENLLEDAFTHSSYANEHpgRKDYEKLEFLGDAVLELAVSDYLYRHFPrLNEGELTRMRSNIVRTEGFSEFAIECGFPAEI 100
Cdd:pfam14622   1 EELLLQALTHKSYANGR--KPYNERLEFLGDAVLELSVSEYLFKKPD-LDEGGLTKLRASIVSEESLAEIAREIGLGKYL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 746090242  101 NLGKGEEKAGARKRKTLLEDVFEAFNGALFLDQGMPAVQHFLH 143
Cdd:pfam14622  78 RLGKGEEETGGSGRESILADALEALIGAIYLDGGFEVAKEFIL 120
 
Name Accession Description Interval E-value
Rnc COG0571
dsRNA-specific ribonuclease [Transcription];
10-211 2.42e-90

dsRNA-specific ribonuclease [Transcription];


Pssm-ID: 440336 [Multi-domain]  Cd Length: 229  Bit Score: 265.04  E-value: 2.42e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090242  10 LKEKYGIKFNNENLLEDAFTHSSYANEHPGRKDYEKLEFLGDAVLELAVSDYLYRHFPRLNEGELTRMRSNIVRTEGFSE 89
Cdd:COG0571    7 LEERLGYRFKDPELLEQALTHRSYANEHGGLENNERLEFLGDAVLGLVVAEYLYRRFPDAPEGELSKLRAALVSEETLAE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090242  90 FAIECGFPAEINLGKGEEKAGARKRKTLLEDVFEAFNGALFLDQGMPAVQHFLHLTVYPLIAEGDF-NASRDYKTELQER 168
Cdd:COG0571   87 IARELGLGDYLRLGKGEEKSGGRRRPSILADAFEALIGAIYLDGGLEAARKFVLRLFEPRLEEIAPgGAGKDYKTALQEW 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 746090242 169 LQVNGPVKIEYQVIAED--ESKPSFKVQLLVNDKKISEGQGRNKK 211
Cdd:COG0571  167 LQARGLPLPEYEVVEEEgpDHAKTFTVEVLVGGKVLGEGTGRSKK 211
RNaseIII TIGR02191
ribonuclease III, bacterial; This family consists of bacterial examples of ribonuclease III. ...
 10-211 2.88e-85

ribonuclease III, bacterial; This family consists of bacterial examples of ribonuclease III. This enzyme cleaves double-stranded rRNA. It is involved in processing ribosomal RNA precursors. It is found even in minimal genones such as Mycoplasma genitalium and Buchnera aphidicola, and in some cases has been shown to be an essential gene. These bacterial proteins contain a double-stranded RNA binding motif (pfam00035) and a ribonuclease III domain (pfam00636). Eukaryotic homologs tend to be much longer proteins with additional domains, localized to the nucleus, and not included in this family. [Transcription, RNA processing]


Pssm-ID: 274024 [Multi-domain]  Cd Length: 220  Bit Score: 252.12  E-value: 2.88e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090242   10 LKEKYGIKFNNENLLEDAFTHSSYANE-HPGRKDYEKLEFLGDAVLELAVSDYLYRHFPRLNEGELTRMRSNIVRTEGFS 88
Cdd:TIGR02191   1 LEKRLGYKFKNPELLEQALTHRSYANEhHKDVKNNERLEFLGDAVLGLVVAEYLFKNFPDASEGELSRLRAALVSEESLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090242   89 EFAIECGFPAEINLGKGEEKAGARKRKTLLEDVFEAFNGALFLDQGMPAVQHFLHLTVYPLIAEGD-FNASRDYKTELQE 167
Cdd:TIGR02191  81 EVARELGLGDFLLLGKGEEKSGGRRRDSILADAFEALIGAIYLDSGLEAARKFILKLLIPRIDAIIkEETLKDYKTALQE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 746090242  168 RLQVNGPVKIEYQVIAED--ESKPSFKVQLLVNDKKISEGQGRNKK 211
Cdd:TIGR02191 161 WAQARGKPLPEYRLIKEEgpDHDKEFTVEVSVNGEPYGEGKGKSKK 206
RIBOc cd00593
RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and ...
 23-154 5.08e-54

RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional control of mRNA stability and translational efficiency. It is involved in the processing of ribosomal RNA precursors. Prokaryotic RNAse III also plays a role in the maturation of tRNA precursors and in the processing of phage and plasmid transcripts. Eukaryotic RNase III's participate (through direct cleavage) in rRNA processing, in processing of small nucleolar RNAs (snoRNAs) and snRNA's (components of the spliceosome). In eukaryotes RNase III or RNaseIII like enzymes such as Dicer are involved in RNAi (RNA interference) and miRNA (micro-RNA) gene silencing.


Pssm-ID: 238333  Cd Length: 133  Bit Score: 169.72  E-value: 5.08e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090242  23 LLEDAFTHSSYANEHPgRKDYEKLEFLGDAVLELAVSDYLYRHFPRLNEGELTRMRSNIVRTEGFSEFAIECGFPAEINL 102
Cdd:cd00593    2 LLLEALTHPSYANEHG-RFNNERLEFLGDAVLELVVTEYLFKKFPDLSEGDLTRLRSALVSNETLARLARELGLGKYLRL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 746090242 103 GKGEEKAGARKRKTLLEDVFEAFNGALFLDQGMPAVQHFLHLTVYPLIAEGD 154
Cdd:cd00593   81 GKGEEKSGGRLRPKILADVFEALIGAIYLDGGFEAARKFLLRLLGPLIEEIS 132
RIBOc smart00535
Ribonuclease III family;
22-152 5.08e-49

Ribonuclease III family;


Pssm-ID: 197778  Cd Length: 129  Bit Score: 156.61  E-value: 5.08e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090242    22 NLLEDAFTHSSYANEHPgrkDYEKLEFLGDAVLELAVSDYLYRHFPRLNEGELTRMRSNIVRTEGFSEFAIECGFPAEIN 101
Cdd:smart00535   1 SLLLRALTHASYSNEHE---HNERLEFLGDAVLELVVTEYLYKKYPDLSEGDLSRLRSALVSNETLARLAKKLGLGEFIR 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 746090242   102 LGKGEEKAGARKRKTLLEDVFEAFNGALFLDQGMPAVQHFLHLTVYPLIAE 152
Cdd:smart00535  78 LGRGEAISGGRDKPKILADVFEALIGAIYLDSGLEAAREFIRDLLGPRLDE 128
Ribonucleas_3_3 pfam14622
Ribonuclease-III-like; Members of this family are involved in rDNA transcription and rRNA ...
 21-143 1.27e-36

Ribonuclease-III-like; Members of this family are involved in rDNA transcription and rRNA processing. They probably also cleave a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end; they are involved in polyadenylation-independent transcription termination. Some members may be mitochondrial ribosomal protein subunit L15, others may be 60S ribosomal protein L3.


Pssm-ID: 434075  Cd Length: 127  Bit Score: 124.98  E-value: 1.27e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090242   21 ENLLEDAFTHSSYANEHpgRKDYEKLEFLGDAVLELAVSDYLYRHFPrLNEGELTRMRSNIVRTEGFSEFAIECGFPAEI 100
Cdd:pfam14622   1 EELLLQALTHKSYANGR--KPYNERLEFLGDAVLELSVSEYLFKKPD-LDEGGLTKLRASIVSEESLAEIAREIGLGKYL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 746090242  101 NLGKGEEKAGARKRKTLLEDVFEAFNGALFLDQGMPAVQHFLH 143
Cdd:pfam14622  78 RLGKGEEETGGSGRESILADALEALIGAIYLDGGFEVAKEFIL 120
Ribonuclease_3 pfam00636
Ribonuclease III domain;
44-134 3.94e-25

Ribonuclease III domain;


Pssm-ID: 459883  Cd Length: 101  Bit Score: 94.65  E-value: 3.94e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090242   44 EKLEFLGDAVLELAVSDYLYRHFPRLNEGELTRMRSNIVRTEGFSEFAIECGFPAEI------------NLGKGEEKAGA 111
Cdd:pfam00636   1 ERLEFLGDAVLELYVREYLFEKFPDLREGDLHRLRSALVSNEALAKLARKLGLEKFLteeeldirrrnnALGKGPKRADG 80

                          90       100
                  ....*....|....*....|...
gi 746090242  112 RKRKtlLEDVFEAFNGALFLDQG 134
Cdd:pfam00636  81 KEKV--LADAFEALIGALYLDGG 101
DSRM_RNAse_III_family cd10845
double-stranded RNA binding motif of ribonuclease III (RNase III) and similar proteins; RNase ...
 159-211 4.34e-13

double-stranded RNA binding motif of ribonuclease III (RNase III) and similar proteins; RNase III (EC 3.1.26.3; also known as ribonuclease 3) digests double-stranded RNA formed within single-strand substrates, but not RNA-DNA hybrids. It is involved in the processing of rRNA precursors, viral transcripts, some mRNAs, and at least 1 tRNA (metY, a minor form of tRNA-init-Met). It cleaves the 30S primary rRNA transcript to yield the immediate precursors to the 16S and 23S rRNAs. The cleavage can occur in assembled 30S, 50S, and even 70S subunits and is influenced by the presence of ribosomal proteins. The RNase III family also includes the mitochondrion-specific ribosomal protein mL44 subfamily, which is composed of mitochondrial 54S ribosomal protein L3 (MRPL3) and mitochondrial 39S ribosomal protein L44 (MRPL44). Members of this family contain an RNase III domain and a C-terminal double-stranded RNA binding motif (DSRM). DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.


Pssm-ID: 380682 [Multi-domain]  Cd Length: 69  Bit Score: 62.12  E-value: 4.34e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 746090242 159 RDYKTELQERLQVNGPVKIEYQVIAE--DESKPSFKVQLLVNDKKISEGQGRNKK 211
Cdd:cd10845    1 KDYKTALQEYLQKRGLPLPEYELVEEegPDHNKTFTVEVKVNGKVIGEGTGRSKK 55
dsrm pfam00035
Double-stranded RNA binding motif; Sequences gathered for seed by HMM_iterative_training ...
 161-213 6.66e-06

Double-stranded RNA binding motif; Sequences gathered for seed by HMM_iterative_training Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localization of at least five different mRNAs in the early Drosophila embryo. Also by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA.


Pssm-ID: 425434 [Multi-domain]  Cd Length: 66  Bit Score: 42.60  E-value: 6.66e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 746090242  161 YKTELQERLQVNGPvKIEYQVIAEDES--KPSFKVQLLVNDKKISEGQGRNKKAA 213
Cdd:pfam00035   1 PKSLLQEYAQKNGK-PPPYEYVSEEGPphSPKFTVTVKVDGKLYGSGTGSSKKEA 54
DSRM smart00358
Double-stranded RNA binding motif;
161-214 3.91e-05

Double-stranded RNA binding motif;


Pssm-ID: 214634 [Multi-domain]  Cd Length: 67  Bit Score: 40.32  E-value: 3.91e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 746090242   161 YKTELQERLQVNGpVKIEYQVIAED--ESKPSFKVQLLVNDKKISEGQGRNKKAAE 214
Cdd:smart00358   1 PKSLLQELAQKRK-LPPEYELVKEEgpDHAPRFTVTVKVGGKRTGEGEGSSKKEAK 55
DSRM_RNT1p-like cd19876
double-stranded RNA binding motif of Saccharomyces cerevisiae ribonuclease 3 (RNT1p) and ...
 158-226 5.01e-03

double-stranded RNA binding motif of Saccharomyces cerevisiae ribonuclease 3 (RNT1p) and similar proteins; RNT1p (EC 3.1.26.3; also known as ribonuclease III (RNase III)) is a dsRNA-specific nuclease that cleaves eukaryotic pre-ribosomal RNA at the U3 snoRNP-dependent A0 site in the 5'-external transcribed spacer (ETS) and in the 3'-ETS. RNT1p contains a double-stranded RNA binding motif (DSRM) at the C-terminus. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.


Pssm-ID: 380705  Cd Length: 69  Bit Score: 34.62  E-value: 5.01e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 746090242 158 SRDYKTELQERLqvnGPV--KIEYQVI-AEDESKPSFKVQLLVNDKKISEGQGRNKKAAEQQAAQAALDKNK 226
Cdd:cd19876    1 DKFAKQKLYSLI---GPAslKPEYVVVkKEGGNDPNYTVACRINGEVLGTGVGRSIKKAGQRAAMSALSNKK 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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