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Conserved domains on  [gi|746090398|ref|WP_039157117|]
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MULTISPECIES: patatin family protein [Lactobacillus]

Protein Classification

patatin family protein( domain architecture ID 11468705)

patatin family protein similar to Escherichia coli YjjU; the family includes putative phospholipases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YjjU COG4667
Predicted phospholipase, patatin/cPLA2 family [Lipid transport and metabolism];
1-278 9.15e-128

Predicted phospholipase, patatin/cPLA2 family [Lipid transport and metabolism];


:

Pssm-ID: 443704 [Multi-domain]  Cd Length: 281  Bit Score: 364.49  E-value: 9.15e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398   1 MKKGLVMEGGAMRCMFTAGVIDTLMKEKIKFDGAIGVSAGAAFGCNYKSEQIGRVLRYNIKYAHDPRLSSWQSWLKTGDL 80
Cdd:COG4667    4 MKTALVLEGGGMRGIFTAGVLDALLEEGIPFDLVIGVSAGALNGASYLSRQPGRARRVITDYATDPRFFSLRNFLRGGNL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398  81 YGADFCYRELPVKLDIFDTNAFQKNPMDFWCVATDIDNGEAVYHKLLSGKEADLKWIRASSSIPVFARPVEIGNRKYWDG 160
Cdd:COG4667   84 FDLDFLYDEIPNELLPFDFETFKASPREFYVVATNADTGEAEYFSKKDDDYDLLDALRASSALPLLYPPVEIDGKRYLDG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398 161 GISDSIPIKFFEKIGYQKNVVILTQPLSYRKEASKLYPALELVLHKYPAVLKKLKTRATDYNDVLSYIRKKEVQGKMLVI 240
Cdd:COG4667  164 GVADSIPVREAIRDGADKIVVILTRPRGYRKKPSKFKRLLRRLYRKYPKLVEALLNRHERYNETLEFIEQLEKEGKIFVI 243

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 746090398 241 RPPYPLDIGTMEKDPKELKRVYNIGVKEAQNCLKAVQS 278
Cdd:COG4667  244 RPPKPLTVSRLERDPEKLRALYELGYEDARKFLAELKA 281
 
Name Accession Description Interval E-value
YjjU COG4667
Predicted phospholipase, patatin/cPLA2 family [Lipid transport and metabolism];
1-278 9.15e-128

Predicted phospholipase, patatin/cPLA2 family [Lipid transport and metabolism];


Pssm-ID: 443704 [Multi-domain]  Cd Length: 281  Bit Score: 364.49  E-value: 9.15e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398   1 MKKGLVMEGGAMRCMFTAGVIDTLMKEKIKFDGAIGVSAGAAFGCNYKSEQIGRVLRYNIKYAHDPRLSSWQSWLKTGDL 80
Cdd:COG4667    4 MKTALVLEGGGMRGIFTAGVLDALLEEGIPFDLVIGVSAGALNGASYLSRQPGRARRVITDYATDPRFFSLRNFLRGGNL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398  81 YGADFCYRELPVKLDIFDTNAFQKNPMDFWCVATDIDNGEAVYHKLLSGKEADLKWIRASSSIPVFARPVEIGNRKYWDG 160
Cdd:COG4667   84 FDLDFLYDEIPNELLPFDFETFKASPREFYVVATNADTGEAEYFSKKDDDYDLLDALRASSALPLLYPPVEIDGKRYLDG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398 161 GISDSIPIKFFEKIGYQKNVVILTQPLSYRKEASKLYPALELVLHKYPAVLKKLKTRATDYNDVLSYIRKKEVQGKMLVI 240
Cdd:COG4667  164 GVADSIPVREAIRDGADKIVVILTRPRGYRKKPSKFKRLLRRLYRKYPKLVEALLNRHERYNETLEFIEQLEKEGKIFVI 243

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 746090398 241 RPPYPLDIGTMEKDPKELKRVYNIGVKEAQNCLKAVQS 278
Cdd:COG4667  244 RPPKPLTVSRLERDPEKLRALYELGYEDARKFLAELKA 281
Pat_hypo_Ecoli_yjju_like cd07208
Hypothetical patatin similar to yjju protein of Escherichia coli; Patatin-like phospholipase ...
 5-269 2.19e-114

Hypothetical patatin similar to yjju protein of Escherichia coli; Patatin-like phospholipase similar to yjju protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins, and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.


Pssm-ID: 132847 [Multi-domain]  Cd Length: 266  Bit Score: 329.96  E-value: 2.19e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398   5 LVMEGGAMRCMFTAGVIDTLMKEKIK-FDGAIGVSAGAAFGCNYKSEQIGRVLRYNIKYAHDPRLSSWQSWLKTGDLYGA 83
Cdd:cd07208    1 LVLEGGGMRGAYTAGVLDAFLEAGIRpFDLVIGVSAGALNAASYLSGQRGRALRINTKYATDPRYLGLRSLLRTGNLFDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398  84 DFCYRELPVKLDIFDTNAFQKNPMDFWCVATDIDNGEAVYHKLLSGKEADLKWIRASSSIPVFARPVEIGNRKYWDGGIS 163
Cdd:cd07208   81 DFLYDELPDGLDPFDFEAFAASPARFYVVATDADTGEAVYFDKPDILDDLLDALRASSALPGLFPPVRIDGEPYVDGGLS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398 164 DSIPIKFFEKIGYQKNVVILTQPLSYRKEASKLYPALELVLHKYPAVLKKLKTRATDYNDVLSYIRKKEVQGKMLVIRPP 243
Cdd:cd07208  161 DSIPVDKAIEDGADKIVVILTRPRGYRKKPSKSSPLAKLLYRKYPNLVEALLRRHSRYNETLEFIRRLEAEGKIFVIAPE 240

                        250       260
                 ....*....|....*....|....*.
gi 746090398 244 YPLDIGTMEKDPKELKRVYNIGVKEA 269
Cdd:cd07208  241 KPLKVSRLERDPEKLEALYDLGYEDA 266
Patatin pfam01734
Patatin-like phospholipase; This family consists of various patatin glycoproteins from plants. ...
 5-171 9.38e-22

Patatin-like phospholipase; This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.


Pssm-ID: 396341  Cd Length: 190  Bit Score: 89.98  E-value: 9.38e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398    5 LVMEGGAMRCMFTAGVIDTLMKEKIKFDGAIGVSAGA----AFGCNYKSEQIG---------RVLRYNIKYAHDPRLSSW 71
Cdd:pfam01734   1 LVLSGGGARGAYHLGVLKALGEAGIRFDVISGTSAGAinaaLLALGRDPEEIEdllleldlnLFLSLIRKRALSLLALLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398   72 QSWLKTGdLYGADFCYRELPVKLDIFDTNAFQKNP-----MDFWCVATDIDNGEAVYHKLLSGKEAD-----LKWIRASS 141
Cdd:pfam01734  81 GLIGEGG-LFDGDALRELLRKLLGDLTLEELAARLslllvVALRALLTVISTALGTRARILLPDDLDddedlADAVLASS 159

                         170       180       190
                  ....*....|....*....|....*....|
gi 746090398  142 SIPVFARPVEIGNRKYWDGGISDSIPIKFF 171
Cdd:pfam01734 160 ALPGVFPPVRLDGELYVDGGLVDNVPVEAA 189
PRK10279 PRK10279
patatin-like phospholipase RssA;
1-182 2.83e-05

patatin-like phospholipase RssA;


Pssm-ID: 182352 [Multi-domain]  Cd Length: 300  Bit Score: 44.70  E-value: 2.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398   1 MKKGLVMEGGAMRCMFTAGVIDTLMKEKIKFDGAIGVSAGAAFGCNYKSEQIGRVLRY--NIKYAHDPRLSSWqSWLKTG 78
Cdd:PRK10279   4 IKIGLALGSGAARGWSHIGVINALKKVGIEIDIVAGCSIGSLVGAAYACDRLSALEDWvtSFSYWDVLRLMDL-SWQRGG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398  79 DLYGADF--CYRELPVKLDIFDTNafqknpMDFWCVATDIDNGEAVYHKllsgkEADLKW-IRASSSIPVFARPVEIGNr 155
Cdd:PRK10279  83 LLRGERVfnQYREIMPETEIENCS------RRFGAVATNLSTGRELWFT-----EGDLHLaIRASCSMPGLMAPVAHNG- 150

                        170       180
                 ....*....|....*....|....*....
gi 746090398 156 kYW--DGGISDSIPIKFFEKIGyqKNVVI 182
Cdd:PRK10279 151 -YWlvDGAVVNPVPVSLTRALG--ADIVI 176
 
Name Accession Description Interval E-value
YjjU COG4667
Predicted phospholipase, patatin/cPLA2 family [Lipid transport and metabolism];
1-278 9.15e-128

Predicted phospholipase, patatin/cPLA2 family [Lipid transport and metabolism];


Pssm-ID: 443704 [Multi-domain]  Cd Length: 281  Bit Score: 364.49  E-value: 9.15e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398   1 MKKGLVMEGGAMRCMFTAGVIDTLMKEKIKFDGAIGVSAGAAFGCNYKSEQIGRVLRYNIKYAHDPRLSSWQSWLKTGDL 80
Cdd:COG4667    4 MKTALVLEGGGMRGIFTAGVLDALLEEGIPFDLVIGVSAGALNGASYLSRQPGRARRVITDYATDPRFFSLRNFLRGGNL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398  81 YGADFCYRELPVKLDIFDTNAFQKNPMDFWCVATDIDNGEAVYHKLLSGKEADLKWIRASSSIPVFARPVEIGNRKYWDG 160
Cdd:COG4667   84 FDLDFLYDEIPNELLPFDFETFKASPREFYVVATNADTGEAEYFSKKDDDYDLLDALRASSALPLLYPPVEIDGKRYLDG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398 161 GISDSIPIKFFEKIGYQKNVVILTQPLSYRKEASKLYPALELVLHKYPAVLKKLKTRATDYNDVLSYIRKKEVQGKMLVI 240
Cdd:COG4667  164 GVADSIPVREAIRDGADKIVVILTRPRGYRKKPSKFKRLLRRLYRKYPKLVEALLNRHERYNETLEFIEQLEKEGKIFVI 243

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 746090398 241 RPPYPLDIGTMEKDPKELKRVYNIGVKEAQNCLKAVQS 278
Cdd:COG4667  244 RPPKPLTVSRLERDPEKLRALYELGYEDARKFLAELKA 281
Pat_hypo_Ecoli_yjju_like cd07208
Hypothetical patatin similar to yjju protein of Escherichia coli; Patatin-like phospholipase ...
 5-269 2.19e-114

Hypothetical patatin similar to yjju protein of Escherichia coli; Patatin-like phospholipase similar to yjju protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins, and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.


Pssm-ID: 132847 [Multi-domain]  Cd Length: 266  Bit Score: 329.96  E-value: 2.19e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398   5 LVMEGGAMRCMFTAGVIDTLMKEKIK-FDGAIGVSAGAAFGCNYKSEQIGRVLRYNIKYAHDPRLSSWQSWLKTGDLYGA 83
Cdd:cd07208    1 LVLEGGGMRGAYTAGVLDAFLEAGIRpFDLVIGVSAGALNAASYLSGQRGRALRINTKYATDPRYLGLRSLLRTGNLFDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398  84 DFCYRELPVKLDIFDTNAFQKNPMDFWCVATDIDNGEAVYHKLLSGKEADLKWIRASSSIPVFARPVEIGNRKYWDGGIS 163
Cdd:cd07208   81 DFLYDELPDGLDPFDFEAFAASPARFYVVATDADTGEAVYFDKPDILDDLLDALRASSALPGLFPPVRIDGEPYVDGGLS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398 164 DSIPIKFFEKIGYQKNVVILTQPLSYRKEASKLYPALELVLHKYPAVLKKLKTRATDYNDVLSYIRKKEVQGKMLVIRPP 243
Cdd:cd07208  161 DSIPVDKAIEDGADKIVVILTRPRGYRKKPSKSSPLAKLLYRKYPNLVEALLRRHSRYNETLEFIRRLEAEGKIFVIAPE 240

                        250       260
                 ....*....|....*....|....*.
gi 746090398 244 YPLDIGTMEKDPKELKRVYNIGVKEA 269
Cdd:cd07208  241 KPLKVSRLERDPEKLEALYDLGYEDA 266
RssA COG1752
Predicted acylesterase/phospholipase RssA, containd patatin domain [General function ...
 1-186 6.88e-33

Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only];


Pssm-ID: 441358 [Multi-domain]  Cd Length: 261  Bit Score: 121.16  E-value: 6.88e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398   1 MKKGLVMEGGAMRCMFTAGVIDTLMKEKIKFDGAIGVSAGA----AFGCNYKSEQIGRVLRyNIKYAHDPRLSSWQSWLK 76
Cdd:COG1752    5 PKIGLVLSGGGARGAAHIGVLKALEEAGIPPDVIAGTSAGAivgaLYAAGYSADELEELWR-SLDRRDLFDLSLPRRLLR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398  77 TGD------LYGADFCYRELpvkLDIFDTNAFQKNPMDFWCVATDIDNGEAVYHKLLSGKEAdlkwIRASSSIPVFARPV 150
Cdd:COG1752   84 LDLglspggLLDGDPLRRLL---ERLLGDRDFEDLPIPLAVVATDLETGREVVFDSGPLADA----VRASAAIPGVFPPV 156

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 746090398 151 EIGNRKYWDGGISDSIPIKFFEKIGYQKNVVILTQP 186
Cdd:COG1752  157 EIDGRLYVDGGVVNNLPVDPARALGADRVIAVDLNP 192
Patatin pfam01734
Patatin-like phospholipase; This family consists of various patatin glycoproteins from plants. ...
 5-171 9.38e-22

Patatin-like phospholipase; This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.


Pssm-ID: 396341  Cd Length: 190  Bit Score: 89.98  E-value: 9.38e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398    5 LVMEGGAMRCMFTAGVIDTLMKEKIKFDGAIGVSAGA----AFGCNYKSEQIG---------RVLRYNIKYAHDPRLSSW 71
Cdd:pfam01734   1 LVLSGGGARGAYHLGVLKALGEAGIRFDVISGTSAGAinaaLLALGRDPEEIEdllleldlnLFLSLIRKRALSLLALLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398   72 QSWLKTGdLYGADFCYRELPVKLDIFDTNAFQKNP-----MDFWCVATDIDNGEAVYHKLLSGKEAD-----LKWIRASS 141
Cdd:pfam01734  81 GLIGEGG-LFDGDALRELLRKLLGDLTLEELAARLslllvVALRALLTVISTALGTRARILLPDDLDddedlADAVLASS 159

                         170       180       190
                  ....*....|....*....|....*....|
gi 746090398  142 SIPVFARPVEIGNRKYWDGGISDSIPIKFF 171
Cdd:pfam01734 160 ALPGVFPPVRLDGELYVDGGLVDNVPVEAA 189
Pat_hypo_Ecoli_Z1214_like cd07209
Hypothetical patatin similar to Z1214 protein of Escherichia coli; Patatin-like phospholipase ...
 5-197 2.62e-21

Hypothetical patatin similar to Z1214 protein of Escherichia coli; Patatin-like phospholipase similar to Z1214 protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.


Pssm-ID: 132848 [Multi-domain]  Cd Length: 215  Bit Score: 89.27  E-value: 2.62e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398   5 LVMEGGAMRCMFTAGVIDTLMKEKIKFDGAIGVSAGA----AFGCNyKSEQIGRVlrYNIkyahdprlssWQSwLKTGDL 80
Cdd:cd07209    1 LVLSGGGALGAYQAGVLKALAEAGIEPDIISGTSIGAingaLIAGG-DPEAVERL--EKL----------WRE-LSREDV 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398  81 YgadfcYRELPVKLDIFDTnaFQKNPMDFW---CVATDIDNGEAVYHKLlSGKEADLKWIRASSSIPVFARPVEIGNRKY 157
Cdd:cd07209   67 F-----LRGLLDRALDFDT--LRLLAILFAglvIVAVNVLTGEPVYFDD-IPDGILPEHLLASAALPPFFPPVEIDGRYY 138

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 746090398 158 WDGGISDSIPIKFFEKIGYQKNVVILTQPLSYRKEASKLY 197
Cdd:cd07209  139 WDGGVVDNTPLSPAIDLGADEIIVVSLSDKGRDDRKGTPP 178
Pat_PNPLA6_PNPLA7_NTE1_like cd07205
Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; ...
 4-168 1.58e-18

Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Patatin-like phospholipase domain containing protein 6 (PNPLA6) and protein 7 (PNPLA7) are included in this family. PNPLA6 is commonly known as Neuropathy Target Esterase (NTE). NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. PNPLA7 is an insulin-regulated phospholipase that is homologus to Neuropathy Target Esterase (NTE or PNPLA6) and is also known as NTE-related esterase (NRE). Human NRE is predominantly expressed in prostate, white adipose, and pancreatic tissue. NRE hydrolyzes sn-1 esters in lysophosphatidylcholine and lysophosphatidic acid, but shows no lipase activity with substrates like triacylglycerols (TG), cholesteryl esters, retinyl esters (RE), phosphatidylcholine (PC), or monoacylglycerol (MG). This family includes subfamily of PNPLA6 (NTE) and PNPLA7 (NRE)-like phospholipases.


Pssm-ID: 132844 [Multi-domain]  Cd Length: 175  Bit Score: 80.67  E-value: 1.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398   4 GLVMEGGAMRCMFTAGVIDTLMKEKIKFDGAIGVSAGA------AFGcnYKSEQIGRVLRYNIKYAHDPRLSSW-QSWLK 76
Cdd:cd07205    2 GLALSGGGARGLAHIGVLKALEEAGIPIDIVSGTSAGAivgalyAAG--YSPEEIEERAKLRSTDLKALSDLTIpTAGLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398  77 TGDLYGADFCyrelpvklDIFDTNAFQKNPMDFWCVATDIDNGEAVYHKllsgkEADL-KWIRASSSIPVFARPVEIGNR 155
Cdd:cd07205   80 RGDKFLELLD--------EYFGDRDIEDLWIPFFIVATDLTSGKLVVFR-----SGSLvRAVRASMSIPGIFPPVKIDGQ 146

                        170
                 ....*....|...
gi 746090398 156 KYWDGGISDSIPI 168
Cdd:cd07205  147 LLVDGGVLNNLPV 159
Pat_NTE_like_bacteria cd07228
Bacterial patatin-like phospholipase domain containing protein 6; Bacterial patatin-like ...
 4-169 1.25e-17

Bacterial patatin-like phospholipase domain containing protein 6; Bacterial patatin-like phospholipase domain containing protein 6. PNPLA6 is commonly known as Neuropathy Target Esterase (NTE). NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. This group includes YCHK and rssA from Escherichia coli as well as Ylbk from Bacillus amyloliquefaciens.


Pssm-ID: 132866 [Multi-domain]  Cd Length: 175  Bit Score: 78.47  E-value: 1.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398   4 GLVMEGGAMRCMFTAGVIDTLMKEKIKFDGAIGVSAGAAFGCNYKSeqigrvlrynikyAHDPRLSSWQSWLKTGDLYG- 82
Cdd:cd07228    2 GLALGSGGARGWAHIGVLRALEEEGIEIDIIAGSSIGALVGALYAA-------------GHLDALEEWVRSLSQRDVLRl 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398  83 ADFC-----------YRELpVKLDIFDTnAFQKNPMDFWCVATDIDNGEAVYhkLLSGKEADLkwIRASSSIPVFARPVE 151
Cdd:cd07228   69 LDLSasrsgllkgekVLEY-LREIMGGV-TIEELPIPFAAVATDLQTGKEVW--FREGSLIDA--IRASISIPGIFAPVE 142

                        170
                 ....*....|....*...
gi 746090398 152 IGNRKYWDGGISDSIPIK 169
Cdd:cd07228  143 HNGRLLVDGGVVNPIPVS 160
DUF6363 pfam19890
Domain of unknown function (DUF6363); This presumed domain is functionally uncharacterized. ...
 207-281 2.42e-17

Domain of unknown function (DUF6363); This presumed domain is functionally uncharacterized. This domain is found at the C-terminal of patatin-like proteins from bacteria. There is a conserved tyrosine residue and a conserved FxxxPP sequence motif.


Pssm-ID: 466223 [Multi-domain]  Cd Length: 75  Bit Score: 74.49  E-value: 2.42e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 746090398  207 YPAVLKKLKTRATDYNDVLSYIRKKEVQGKMLVIRPPYPLDIGTMEKDPKELKRVYNIGVKEAQNCLKAVQSYLK 281
Cdd:pfam19890   1 YPKLVDALLKRYESYNETLDFIENPEKEGKAFVIRPEKPLKSSRLESDPEKLEADYELGYEDGRRFLEELKEFLN 75
Pat_hypo_W_succinogenes_WS1459_like cd07210
Hypothetical patatin similar to WS1459 of Wolinella succinogenes; Patatin-like phospholipase. ...
 4-169 1.86e-16

Hypothetical patatin similar to WS1459 of Wolinella succinogenes; Patatin-like phospholipase. This family predominantly consists of bacterial patatin glycoproteins. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.


Pssm-ID: 132849 [Multi-domain]  Cd Length: 221  Bit Score: 76.23  E-value: 1.86e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398   4 GLVMEGGAMRCMFTAGVIDTLMKEKIKFDGAIGVSAGA----AFGCNYKSEQI-GRVLRYNIKYAHDPRLSSWQSWLKTG 78
Cdd:cd07210    2 ALVLSSGFFGFYAHLGFLAALLEMGLEPSAISGTSAGAlvggLFASGISPDEMaELLLSLERKDFWMFWDPPLRGGLLSG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398  79 DLyGADFCYRELPVKldifdtnAFQKNPMDFWCVATDIDNGEAVYHKllsgkEADL-KWIRASSSIPVFARPVEIGNRKY 157
Cdd:cd07210   82 DR-FAALLREHLPPD-------RFEELRIPLAVSVVDLTSRETLLLS-----EGDLaEAVAASCAVPPLFQPVEIGGRPF 148

                        170
                 ....*....|..
gi 746090398 158 WDGGISDSIPIK 169
Cdd:cd07210  149 VDGGVADRLPFD 160
Patatin cd07198
Patatin-like phospholipase; Patatin is a storage protein of the potato tuber that shows ...
 5-170 2.97e-16

Patatin-like phospholipase; Patatin is a storage protein of the potato tuber that shows Phospholipase A2 activity (PLA2; EC 3.1.1.4). Patatin catalyzes the nonspecific hydrolysis of phospholipids, glycolipids, sulfolipids, and mono- and diacylglycerols, thereby showing lipid acyl hydrolase activity. The active site includes an oxyanion hole with a conserved GGxR motif; it is found in almost all the members of this family. The catalytic dyad is formed by a serine and an aspartate. Patatin belongs to the alpha-beta hydrolase family which is identified by a characteristic nucleophile elbow with a consensus sequence of Sm-X-Nu-Sm (Sm = small residue, X = any residue and Nu = nucleophile). Members of this family have been found also in vertebrates. This family includes PNPLA (1-9), TGL (3-5), ExoU-like, and SDP1-like subfamilies. There are some additional hypothetical proteins included in this family.


Pssm-ID: 132837 [Multi-domain]  Cd Length: 172  Bit Score: 74.69  E-value: 2.97e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398   5 LVMEGGAMRCMFTAGVIDTLMKEKIKFDGAIGVSAGA----AFGCNYKSEQIGRVLRyniKYAHDPRLSSWQSWLKTGDL 80
Cdd:cd07198    1 LVLSGGGALGIYHVGVAKALRERGPLIDIIAGTSAGAivaaLLASGRDLEEALLLLL---RLSREVRLRFDGAFPPTGRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398  81 YGADFCyrelpVKLDIFDTNAFQKNPMDFWCVATDIDNGEAVYHKLLSGKEAdLKWIRASSSIPVFARPVE--IGNRKYW 158
Cdd:cd07198   78 LGILRQ-----PLLSALPDDAHEDASGKLFISLTRLTDGENVLVSDTSKGEL-WSAVRASSSIPGYFGPVPlsFRGRRYG 151

                        170
                 ....*....|..
gi 746090398 159 DGGISDSIPIKF 170
Cdd:cd07198  152 DGGLSNNLPVAE 163
Pat_ExoU_VipD_like cd07207
ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; ExoU, a 74-kDa enzyme, is ...
 5-173 4.71e-16

ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; ExoU, a 74-kDa enzyme, is a potent virulence factor of Pseudomonas aeruginosa. One of the pathogenic mechanisms of P. aeruginosa is to induce cytotoxicity by the injection of effector proteins (e.g. ExoU) using the type III secretion (T3S) system. ExoU is homologus to patatin and also has the conserved catalytic residues of mammalian calcium-independent (iPLA2) and cytosolic (cPLA2) PLA2. In vitro, ExoU cytotoxity is blocked by the inhibitor of cytosolic and Ca2-independent phospholipase A2 (cPLA2 and iPLA2) enzymes, suggesting that phospholipase A2 inhibitors may represent a novel mode of treatment for acute P. aeruginosa infections. ExoU requires eukaryotic superoxide dismutase as a cofactor and cleaves phosphatidylcholine and phosphatidylethanolamine in vitro. VipD, a 69-kDa cytosolic protein, belongs to the members of Legionella pneumophila family and is homologus to ExoU from Pseudomonas. Even though VipD shows high sequence similarity with several functional regions of ExoU (e.g. oxyanion hole, active site serine, active site aspartate), it has been shown to have no phospholipase activity. This family includes ExoU from Pseudomonas aeruginosa and VipD of Legionella pneumophila.


Pssm-ID: 132846  Cd Length: 194  Bit Score: 74.62  E-value: 4.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398   5 LVMEGGAMRCMFTAGVIDTLMKEKIKFDGAIGVSAGA------AFGCNYK--SEQIGRVLRYNIKYAHDPRLSSWQSWLK 76
Cdd:cd07207    2 LVFEGGGAKGIAYIGALKALEEAGILKKRVAGTSAGAitaallALGYSAAdiKDILKETDFAKLLDSPVGLLFLLPSLFK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398  77 TGDLYGADFCYRELPVKL-----DIFDTNAFQKNPMD-FWC---VATDIDNGEAVYhklLSGKEADL----KWIRASSSI 143
Cdd:cd07207   82 EGGLYKGDALEEWLRELLkektgNSFATSLLRDLDDDlGKDlkvVATDLTTGALVV---FSAETTPDmpvaKAVRASMSI 158

                        170       180       190
                 ....*....|....*....|....*....|.
gi 746090398 144 PVFARPVEIGNRKYW-DGGISDSIPIKFFEK 173
Cdd:cd07207  159 PFVFKPVRLAKGDVYvDGGVLDNYPVWLFDG 189
PRK10279 PRK10279
patatin-like phospholipase RssA;
1-182 2.83e-05

patatin-like phospholipase RssA;


Pssm-ID: 182352 [Multi-domain]  Cd Length: 300  Bit Score: 44.70  E-value: 2.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398   1 MKKGLVMEGGAMRCMFTAGVIDTLMKEKIKFDGAIGVSAGAAFGCNYKSEQIGRVLRY--NIKYAHDPRLSSWqSWLKTG 78
Cdd:PRK10279   4 IKIGLALGSGAARGWSHIGVINALKKVGIEIDIVAGCSIGSLVGAAYACDRLSALEDWvtSFSYWDVLRLMDL-SWQRGG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398  79 DLYGADF--CYRELPVKLDIFDTNafqknpMDFWCVATDIDNGEAVYHKllsgkEADLKW-IRASSSIPVFARPVEIGNr 155
Cdd:PRK10279  83 LLRGERVfnQYREIMPETEIENCS------RRFGAVATNLSTGRELWFT-----EGDLHLaIRASCSMPGLMAPVAHNG- 150

                        170       180
                 ....*....|....*....|....*....
gi 746090398 156 kYW--DGGISDSIPIKFFEKIGyqKNVVI 182
Cdd:PRK10279 151 -YWlvDGAVVNPVPVSLTRALG--ADIVI 176
Pat_PNPLA4 cd07222
Patatin-like phospholipase domain containing protein 4; PNPLA4, also known as GS2 (gene ...
 139-168 1.28e-03

Patatin-like phospholipase domain containing protein 4; PNPLA4, also known as GS2 (gene sequence-2), shows both lipase and transacylation activities. GS2 lipase is expressed in various tissues, predominantly in muscle and adipocytes tissue. It is also expressed in keratinocytes and shows retinyl ester hydrolase, acylglycerol, TG hydrolase, and PLA2 activity. This family includes patatin-like proteins: GS2 from mammals, PNPLA4 (Patatin-like phospholipase domain-containing protein 4), and iPLA2-eta (Calcium-independent phospholipase A2) from Homo sapiens.


Pssm-ID: 132861 [Multi-domain]  Cd Length: 246  Bit Score: 39.24  E-value: 1.28e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 746090398 139 ASSSIPVFA--RPVEIGNRKYWDGGISDSIPI 168
Cdd:cd07222  137 ASCYVPVYAglKPVEYKGQKWIDGGFTNSLPV 168
Pat_Fungal_NTE1 cd07227
Fungal patatin-like phospholipase domain containing protein 6; These are fungal Neuropathy ...
 4-182 1.29e-03

Fungal patatin-like phospholipase domain containing protein 6; These are fungal Neuropathy Target Esterase (NTE), commonly referred to as NTE1. Patatin-like phospholipase. NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. This family includes NTE1 from fungi.


Pssm-ID: 132865 [Multi-domain]  Cd Length: 269  Bit Score: 39.40  E-value: 1.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398   4 GLVMEGGAMRCMFTAGVIDTLMKEKIKFDGAIGVSAGAAFGCNYKSEQ-----IGRVLRYNIKYAHDPRLSSWQSWLKTG 78
Cdd:cd07227   12 GLVLGGGGARGISHIGILQALEEAGIPIDAIGGTSIGSFVGGLYAREAdlvpiFGRAKKFAGRMASMWRFLSDVTYPFAS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746090398  79 DLYGADFcyrelpvKLDIFDTnaFQKNPM-DFW----CVATDIDNGEAVYHKllSGKEadLKWIRASSSIPVFARPVEIG 153
Cdd:cd07227   92 YTTGHEF-------NRGIWKT--FGNTHIeDFWipfyANSTNITHSRMEIHS--SGYA--WRYIRASMSLAGLLPPLSDN 158

                        170       180
                 ....*....|....*....|....*....
gi 746090398 154 NRKYWDGGISDSIPIKFFEKIGYQKNVVI 182
Cdd:cd07227  159 GSMLLDGGYMDNLPVSPMRSLGIRDIFAV 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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