|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15389 |
PRK15389 |
fumarate hydratase; Provisional |
2-536 |
0e+00 |
|
fumarate hydratase; Provisional
Pssm-ID: 237955 [Multi-domain] Cd Length: 536 Bit Score: 1224.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 2 SNKPFYYQDPFPLSKDDTEYRLLSSDFVSVAQFEGQDILKIEPAALTLLAQQAFHDASFMLRPAHQQQVADILSDPEASE 81
Cdd:PRK15389 1 SMPPFKYQDLFPLGKDDTEYRLLTSDGVSVAEFEGREILKVEPEALTLLAEEAFHDISHLLRPAHLQQLAKILDDPEASD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 82 NDKYVALQFLRNSEISAKGILPTCQDTGTAIIVGKKGQNVWTGGNDAEALSQGVYNTFVEDNLRYSQNAALDMYKEVNTG 161
Cdd:PRK15389 81 NDKFVALDLLKNANIAAGGVLPMCQDTGTAIIMGKKGQRVWTGGDDEEALSRGVYDTYTELNLRYSQNAPLDMYEEKNTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 162 TNLPAQIDLYSTEGEDYKFLFVTKGGGSANKTYLYQETKALLTPGKLKSFLIEKMRSLGTAACPPYHIAFVIGGTSAETT 241
Cdd:PRK15389 161 TNLPAQIDIYATEGDEYKFLFMAKGGGSANKTFLYQETKALLNPDRLLAFLVEKMRTLGTAACPPYHLAIVIGGTSAEAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 242 LKTVKLASTKYYDELPTEGNEHGQAFRDVALEQEILEAARDLGLGAQFGGKYFAHDVRIIRLPRHGASCPVGMGVSCSAD 321
Cdd:PRK15389 241 LKTVKLASAKYLDALPTEGNEHGHAFRDLELEQEVLKLTQKLGIGAQFGGKYFCHDVRVIRLPRHGASCPVGIGVSCSAD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 322 RNIKGKINRKGVWLEQLEQNPGKYIPEHLRETGEGDAVKIDLNRPMAEILKTLSQYPVSTRLSLTGTIIVGRDIAHAKLK 401
Cdd:PRK15389 321 RNIKAKITRDGIFLEQLETNPARYLPEVLREKLEGEVVKIDLNRPMAEILAELSKYPVKTRLSLTGTIIVARDIAHAKLK 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 402 ERLDNGEGLPQYIKDHPIYYAGPAKTPEGYPSGSLGPTTAGRMDSYVDLLQANGGSMIMLAKGNRSQQVTDACHKHGGFY 481
Cdd:PRK15389 401 ERLDAGEGLPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVDLFQAAGGSMVMLAKGNRSQQVTDACKKHGGFY 480
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 746223659 482 LGSIGGPAAILAQNSIKSLTCVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQ 536
Cdd:PRK15389 481 LGSIGGPAARLAQDCIKKVEVLEYPELGMEAVWKIEVEDFPAFILVDDKGNDFFK 535
|
|
| TtdA |
COG1951 |
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy ... |
41-341 |
3.85e-132 |
|
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 441554 Cd Length: 289 Bit Score: 385.97 E-value: 3.85e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 41 KIEPAALTLLAQQAFHDASFMLRPAHQQQVADILSDpEASENDKYVALQFLRNSEISAKGILPTCQDTGTAIIVGKKGQN 120
Cdd:COG1951 3 EIDPEDLTEAVAELIIEASYYLPPDVLEALKEALEK-EESPNAKDVLAQILENAEIAAEGKLPICQDTGTAVVFVKIGQD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 121 VWTGGNDAEALSQGVYNTFVEDNLRYSQNAALDmykEVNTGTNLPAQIDLYSTEGEDYKFLFVTKGGGSANKTYLYqetk 200
Cdd:COG1951 82 VPIDGDLEEAINEGVRRAYKEGPLRKSVVDPLT---RKNTGDNTPAVIHIEIVPGDKLEITVAPKGGGSENKSALK---- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 201 aLLTPGK----LKSFLIEKMRSLGTAACPPYHIAFVIGGTsAETTLKTVKLASTKYYDELPTEgnehgqaFRDVALEQEI 276
Cdd:COG1951 155 -MLNPSEglegVKKFVLETVKEAGGNPCPPGIVGVGIGGT-AEKAAKLAKKALLRPLDERNPD-------PRLAELEEEL 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 746223659 277 LEAARDLGLGAQ-FGGKYFAHDVRIIRLPRHGASCPVGMGVSCSADRNIKGKINRKGVWleQLEQN 341
Cdd:COG1951 226 LEAINKLGIGPQgLGGKTTALDVKIERAPRHIASLPVAVNINCWATRHATAVIDGDGPF--ELESP 289
|
|
| Fumerase_C |
pfam05683 |
Fumarase C-terminus; This family consists of the C terminal region of several bacterial ... |
332-536 |
3.92e-131 |
|
Fumarase C-terminus; This family consists of the C terminal region of several bacterial fumarate hydratase proteins (FumA and FumB). Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth.
Pssm-ID: 461714 [Multi-domain] Cd Length: 204 Bit Score: 380.28 E-value: 3.92e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 332 GVWLEQLEQNPGKYIPEHLRETGEgDAVKIDLNRPmaEILKTLSQYPVSTRLSLTGTIIVGRDIAHAKLKERLDNGEGLP 411
Cdd:pfam05683 1 GSGPEQLEPPPLEYWPEWEEDDLA-EAVRVDLNRP--ETREELSKWPVGTRLLLSGTLLTGRDAAHKRIKEMLDKGEPLP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 412 QYIKD--HPIYYAGPAKTPEGYPSGSLGPTTAGRMDSYVDLLQANGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGpA 489
Cdd:pfam05683 78 EYVDLngRPIYYAGPVDTPGGEVVGSAGPTTATRMDKYVDDFLEKGGSMGMIGKGNRGPAVTEACKKHGGFYLGAIGG-A 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 746223659 490 AILAQNSIKSLTCVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQ 536
Cdd:pfam05683 157 AYLAAKAIKKVEVVAFEELGMEAIWEFEVEDFPAFVAVDDKGNSFHK 203
|
|
| ttdB_fumA_fumB |
TIGR00723 |
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S ... |
374-536 |
2.30e-78 |
|
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase beta chain and the C-terminal region of the class I fumarase (where the N-terminal region is homologous to the tartrate dehydratase alpha chain). The activity of archaeal proteins in this subfamily has not been established.
Pssm-ID: 129806 Cd Length: 168 Bit Score: 243.88 E-value: 2.30e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 374 LSQYPVSTRLSLTGTIIVGRDIAHAKLKERLDNGEGLPQYIKDHPIYYAGPAKTPEGYP-SGSLGPTTAGRMDSYVDLLQ 452
Cdd:TIGR00723 3 ILKLKVGDVVYLTGTIFTARDEAHARLLELIDEGKELPFDLNGSVIYHAGPIVTKNGEWeVVSVGPTTSARMNPFEPELL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 453 ANGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAILAQnSIKSLTCVEYPELGM-EAIWKIEVEDF-PAFILVDDK 530
Cdd:TIGR00723 83 EKLGVMAIIGKGGMSKEVVEACRKYKAVYLAFPGGCAALLAQ-SVKKVEGVAWEDLGMpEAIWELEVEDFgPLIVAIDSH 161
|
....*.
gi 746223659 531 GNDFFQ 536
Cdd:TIGR00723 162 GNSIFQ 167
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15389 |
PRK15389 |
fumarate hydratase; Provisional |
2-536 |
0e+00 |
|
fumarate hydratase; Provisional
Pssm-ID: 237955 [Multi-domain] Cd Length: 536 Bit Score: 1224.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 2 SNKPFYYQDPFPLSKDDTEYRLLSSDFVSVAQFEGQDILKIEPAALTLLAQQAFHDASFMLRPAHQQQVADILSDPEASE 81
Cdd:PRK15389 1 SMPPFKYQDLFPLGKDDTEYRLLTSDGVSVAEFEGREILKVEPEALTLLAEEAFHDISHLLRPAHLQQLAKILDDPEASD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 82 NDKYVALQFLRNSEISAKGILPTCQDTGTAIIVGKKGQNVWTGGNDAEALSQGVYNTFVEDNLRYSQNAALDMYKEVNTG 161
Cdd:PRK15389 81 NDKFVALDLLKNANIAAGGVLPMCQDTGTAIIMGKKGQRVWTGGDDEEALSRGVYDTYTELNLRYSQNAPLDMYEEKNTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 162 TNLPAQIDLYSTEGEDYKFLFVTKGGGSANKTYLYQETKALLTPGKLKSFLIEKMRSLGTAACPPYHIAFVIGGTSAETT 241
Cdd:PRK15389 161 TNLPAQIDIYATEGDEYKFLFMAKGGGSANKTFLYQETKALLNPDRLLAFLVEKMRTLGTAACPPYHLAIVIGGTSAEAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 242 LKTVKLASTKYYDELPTEGNEHGQAFRDVALEQEILEAARDLGLGAQFGGKYFAHDVRIIRLPRHGASCPVGMGVSCSAD 321
Cdd:PRK15389 241 LKTVKLASAKYLDALPTEGNEHGHAFRDLELEQEVLKLTQKLGIGAQFGGKYFCHDVRVIRLPRHGASCPVGIGVSCSAD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 322 RNIKGKINRKGVWLEQLEQNPGKYIPEHLRETGEGDAVKIDLNRPMAEILKTLSQYPVSTRLSLTGTIIVGRDIAHAKLK 401
Cdd:PRK15389 321 RNIKAKITRDGIFLEQLETNPARYLPEVLREKLEGEVVKIDLNRPMAEILAELSKYPVKTRLSLTGTIIVARDIAHAKLK 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 402 ERLDNGEGLPQYIKDHPIYYAGPAKTPEGYPSGSLGPTTAGRMDSYVDLLQANGGSMIMLAKGNRSQQVTDACHKHGGFY 481
Cdd:PRK15389 401 ERLDAGEGLPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVDLFQAAGGSMVMLAKGNRSQQVTDACKKHGGFY 480
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 746223659 482 LGSIGGPAAILAQNSIKSLTCVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQ 536
Cdd:PRK15389 481 LGSIGGPAARLAQDCIKKVEVLEYPELGMEAVWKIEVEDFPAFILVDDKGNDFFK 535
|
|
| PRK15391 |
PRK15391 |
class I fumarate hydratase; |
1-546 |
0e+00 |
|
class I fumarate hydratase;
Pssm-ID: 185289 [Multi-domain] Cd Length: 548 Bit Score: 1126.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 1 MSNKPFYYQDPFPLSKDDTEYRLLSSDFVSVAQFEGQDILKIEPAALTLLAQQAFHDASFMLRPAHQQQVADILSDPEAS 80
Cdd:PRK15391 1 MSNKPFIYQAPFPMGKDNTEYYLLTSDYVSVADFDGETILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 81 ENDKYVALQFLRNSEISAKGILPTCQDTGTAIIVGKKGQNVWTGGNDAEALSQGVYNTFVEDNLRYSQNAALDMYKEVNT 160
Cdd:PRK15391 81 ENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEEALSKGVYNTYIEDNLRYSQNAALDMYKEVNT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 161 GTNLPAQIDLYSTEGEDYKFLFVTKGGGSANKTYLYQETKALLTPGKLKSFLIEKMRSLGTAACPPYHIAFVIGGTSAET 240
Cdd:PRK15391 161 GTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAET 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 241 TLKTVKLASTKYYDELPTEGNEHGQAFRDVALEQEILEAARDLGLGAQFGGKYFAHDVRIIRLPRHGASCPVGMGVSCSA 320
Cdd:PRK15391 241 NLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 321 DRNIKGKINRKGVWLEQLEQNPGKYIPEHLRETGEGDAVKIDLNRPMAEILKTLSQYPVSTRLSLTGTIIVGRDIAHAKL 400
Cdd:PRK15391 321 DRNIKAKINREGIWIEKLEHNPGQYIPQELRQAGEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 401 KERLDNGEGLPQYIKDHPIYYAGPAKTPEGYPSGSLGPTTAGRMDSYVDLLQANGGSMIMLAKGNRSQQVTDACHKHGGF 480
Cdd:PRK15391 401 KELIDAGKELPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGF 480
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 746223659 481 YLGSIGGPAAILAQNSIKSLTCVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQVIQSAKCVKC 546
Cdd:PRK15391 481 YLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVNKQCANC 546
|
|
| PRK15390 |
PRK15390 |
fumarate hydratase FumA; Provisional |
1-546 |
0e+00 |
|
fumarate hydratase FumA; Provisional
Pssm-ID: 185288 [Multi-domain] Cd Length: 548 Bit Score: 1070.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 1 MSNKPFYYQDPFPLSKDDTEYRLLSSDFVSVAQFEGQDILKIEPAALTLLAQQAFHDASFMLRPAHQQQVADILSDPEAS 80
Cdd:PRK15390 1 MSNKPFHYQAPFPLKKDDTEYYLLTSEHVSVSEFEGQEILKVAPEALTLLARQAFHDASFMLRPAHQQQVADILRDPEAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 81 ENDKYVALQFLRNSEISAKGILPTCQDTGTAIIVGKKGQNVWTGGNDAEALSQGVYNTFVEDNLRYSQNAALDMYKEVNT 160
Cdd:PRK15390 81 ENDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEAALARGVYNTYIEDNLRYSQNAPLDMYKEVNT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 161 GTNLPAQIDLYSTEGEDYKFLFVTKGGGSANKTYLYQETKALLTPGKLKSFLIEKMRSLGTAACPPYHIAFVIGGTSAET 240
Cdd:PRK15390 161 GTNLPAQIDLYAVDGDEYKFLCIAKGGGSANKTYLYQETKALLTPGKLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAET 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 241 TLKTVKLASTKYYDELPTEGNEHGQAFRDVALEQEILEAARDLGLGAQFGGKYFAHDVRIIRLPRHGASCPVGMGVSCSA 320
Cdd:PRK15390 241 NLKTVKLASAKYYDELPTEGNEHGQAFRDVELEKELLIEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 321 DRNIKGKINRKGVWLEQLEQNPGKYIPEHLRETGEGDAVKIDLNRPMAEILKTLSQYPVSTRLSLTGTIIVGRDIAHAKL 400
Cdd:PRK15390 321 DRNIKAKINRQGIWIEKLEHNPGKYIPEELRKAGEGEAVRVDLNRPMKEILAQLSQYPVSTRLSLNGTIIVGRDIAHAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 401 KERLDNGEGLPQYIKDHPIYYAGPAKTPEGYPSGSLGPTTAGRMDSYVDLLQANGGSMIMLAKGNRSQQVTDACHKHGGF 480
Cdd:PRK15390 401 KERMDNGEGLPQYIKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDQLQAQGGSMIMLAKGNRSQQVTDACKKHGGF 480
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 746223659 481 YLGSIGGPAAILAQNSIKSLTCVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQVIQSAKCVKC 546
Cdd:PRK15390 481 YLGSIGGPAAVLAQGSIKSLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIQLTQCTRC 546
|
|
| PTZ00226 |
PTZ00226 |
fumarate hydratase; Provisional |
2-536 |
0e+00 |
|
fumarate hydratase; Provisional
Pssm-ID: 240319 [Multi-domain] Cd Length: 570 Bit Score: 998.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 2 SNKPFYYQDPFPL--SKDDTEYRLL--SSDFVSVAQF--EGQDILKIEPAALTLLAQQAFHDASFMLRPAHQQQVADILS 75
Cdd:PTZ00226 25 VNPEFNFVPIFQPvdPHDTEEYRRLedLSDYVEVVEVggGGKEILKVPPEALTKLTSYAFSDIQHFLRKSHLAQLRRILD 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 76 DPEASENDKYVALQFLRNSEISAKGILPTCQDTGTAIIVGKKGQNVWTGGNDAEALSQGVYNTFVEDNLRYSQNAALDMY 155
Cdd:PTZ00226 105 DPEASDNDRFVAMTLLKNACIAAGRVLPGCQDTGTAIVLGKRGELIWTGGEDEKALSKGVYNAYTNRNLRYSQLAPLDMF 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 156 KEVNTGTNLPAQIDLYSTEGEDYKFLFVTKGGGSANKTYLYQETKALLTPGKLKSFLIEKMRSLGTAACPPYHIAFVIGG 235
Cdd:PTZ00226 185 DEKNTGCNLPAQIDLYATPGNEYEFLFIAKGGGSANKTFLYQQTKSLLNPKSLRKFLEEKIKTIGTSACPPYHLAVVIGG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 236 TSAETTLKTVKLASTKYYDELPTEGNEHGQAFRDVALEQEILEAARDLGLGAQFGGKYFAHDVRIIRLPRHGASCPVGMG 315
Cdd:PTZ00226 265 LSAEMTLKTVKLASCRYYDSLPTSGDEYGRAFRDLEWEEIILEKTQNIGIGAQFGGKYFAHDVRVIRLPRHGASCPIGIG 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 316 VSCSADRNIKGKINRKGVWLEQLEQNPGKYIPE----HLRETGEgdaVKIDLNRPMAEILKTLSQYPVSTRLSLTGTIIV 391
Cdd:PTZ00226 345 VSCSADRQILAKINKDGVYLEQLEHDPAQYLPDitedDLSKTPV---VKIDLNQPMEEILKQLSKYPVKTRLSLTGTLIV 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 392 GRDIAHAKLKERLDNGEGLPQYIKDHPIYYAGPAKTPEGYPSGSLGPTTAGRMDSYVDLLQANGGSMIMLAKGNRSQQVT 471
Cdd:PTZ00226 422 ARDIAHAKIVEMLENGEPLPEYMKNHPIYYAGPAKTPDGYASGSFGPTTAGRMDSYVDLFMENGGSFITLAKGNRSKAVT 501
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 746223659 472 DACHKHGGFYLGSIGGPAAILAQNSIKSLTCVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQ 536
Cdd:PTZ00226 502 NACKKYGGFYLGSIGGPAAILAKDNIKKVEVLDFPELGMEAVWKIEVENFPAFIVVDDKGNDFYS 566
|
|
| PRK15392 |
PRK15392 |
class I fumarate hydratase; |
3-546 |
0e+00 |
|
class I fumarate hydratase;
Pssm-ID: 185290 [Multi-domain] Cd Length: 550 Bit Score: 919.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 3 NKPFYYQDPFPLSKDDTEYRLLSSDFVSVAQFEGQDILKIEPAALTLLAQQAFHDASFMLRPAHQQQVADILSDPEASEN 82
Cdd:PRK15392 2 SKPFIWQEPFLQNKDGTEYTLISDQHITVTELDGEEVIKIAPEALTLLARQAFYEASFFLRSAHLQQVASILNDPQASSN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 83 DKYVALQFLRNSEISAKGILPTCQDTGTAIIVGKKGQNVWTGGNDAEALSQGVYNTFVEDNLRYSQNAALDMYKEVNTGT 162
Cdd:PRK15392 82 DKYVALQLLRNAEVSAKGVLPNCQDTGTATIVASKGQQIWTGGNDAEALSKGIYSTFQENNLRFSQNAPLDMYTEVNTQT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 163 NLPAQIDLYSTEGEDYKFLFVTKGGGSANKTYLYQETKALLTPGKLKSFLIEKMRSLGTAACPPYHIAFVIGGTSAETTL 242
Cdd:PRK15392 162 NLPAQIDISAVAGDEYHFLCVNKGGGSANKAALYQETKSLLQPEKLTAFLIEKMKSLGTAACPPYHIAFVVGGLSADQTL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 243 KTVKLASTKYYDELPTEGNEHGQAFRDVALEQEILEAARDLGLGAQFGGKYFAHDVRIIRLPRHGASCPVGMGVSCSADR 322
Cdd:PRK15392 242 KVAKLASTKYYDNLPTSGNEQGQAFRDIELEKVLLEASQQFGIGAQFGGKYFAHDIRVIRLPRHGGSCPIAMALSCSADR 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 323 NIKGKINRKGVWLEQLEQNPGKYIPEHLRETGEGDAVKIDLNRPMAEILKTLSQYPVSTRLSLTGTIIVGRDIAHAKLKE 402
Cdd:PRK15392 322 NIKAKINKHGIWLEKLEHNPGQYIPASLREENHAQHVQLDLNRPLRDVMQDLARLPVGTRVSLSGPIVVARDIAHAKIKA 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 403 RLDNGEGLPQYIKDHPIYYAGPAKTPEGYPSGSLGPTTAGRMDSYVDLLQANGGSMIMLAKGNRSQQVTDACHKHGGFYL 482
Cdd:PRK15392 402 RLDSGEPMPEYLKHHIVYYAGPAKTPENMACGSLGPTTGGRMDGYVDTFQAAGGSLVMLSKGNRSQQVTDACHKHGGFNL 481
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 746223659 483 GSIGGPAAILAQNSIKSLTCVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFF-QVIQSAKCVKC 546
Cdd:PRK15392 482 GSIGGAAALLAQEYVKSLRCLEYPELGMEAVWMMEVENLPAFILVDDKGNNFFsQFEQQHRCASC 546
|
|
| PLN00133 |
PLN00133 |
class I-fumerate hydratase; Provisional |
5-536 |
0e+00 |
|
class I-fumerate hydratase; Provisional
Pssm-ID: 215068 [Multi-domain] Cd Length: 576 Bit Score: 919.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 5 PFYYQDPF-PLSKDDTEYRLLSSDFVSVAQFEGQDILKIEPAALTLLAQQAFHDASFMLRPAHQQQVADILSDPEASEND 83
Cdd:PLN00133 40 AFDYQPLFdSNAKKTVPWRKLTGDHVSVVEAAGEKYLKVAPEALTLLSDTAMRDVAHLLRPGHLQQLRNILDDPEASDND 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 84 KYVALQFLRNSEISAKGILPTCQDTGTAIIVGKKGQNVWTGGNDAEALSQGVYNTFVEDNLRYSQNAALDMYKEVNTGTN 163
Cdd:PLN00133 120 RFVALELLKNANIAAGRVLPGCQDTGTAIVMGKRGQRVLTDGEDEEHLSRGVYDAYTDTNLRYSQVAPLDMFEEKNTGTN 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 164 LPAQIDLYSTEGEDYKFLFVTKGGGSANKTYLYQETKALLTPGKLKSFLIEKMRSLGTAACPPYHIAFVIGGTSAETTLK 243
Cdd:PLN00133 200 LPAQIDLYAAKGDEYHFQFIAKGGGSANKTFLYQQTKALLNEGSLEAFLEEKIKTIGTSACPPYHLAIVIGGLSAEQNLK 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 244 TVKLASTKYYDELPTEGNEHGQAFRDVALEQEILEAARDLGLGAQFGGKYFAHDVRIIRLPRHGASCPVGMGVSCSADRN 323
Cdd:PLN00133 280 TVKLASTRYYDTLPTSGNALGRAFRDLEWEEKILKMTRGLGIGAQFGGKYFCHDVRVIRLPRHGASCPVGIGVSCSADRQ 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 324 IKGKINRKGVWLEQLEQNPGKYIPEHLRETGEGDAVKIDLNRPMAEILKTLSQYPVSTRLSLTGTIIVGRDIAHAKLKER 403
Cdd:PLN00133 360 ALGKITKDGVFLEALETDPSKYLPDVTEDSLSDDVVKVDLNRPMSEIRETLSAHPVRTRLSLTGTLVVARDIAHAKLLER 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 404 LDNGEGLPQYIKDHPIYYAGPAKTPEGYPSGSLGPTTAGRMDSYVDLLQANGGSMIMLAKGNRSQQVTDACHKHGGFYLG 483
Cdd:PLN00133 440 LEAGEGLPQYAKDHIIYYAGPAKTPEGYASGSFGPTTAGRMDSYVDRFMAAGGSFVTLAKGNRSAQVTNACKKHGGFYLG 519
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 746223659 484 SIGGPAAILAQNSIKSLTCVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQ 536
Cdd:PLN00133 520 SIGGPAAILAQNCIKKVEVLENPELGMEAVWKIEVEDFPAFIVVDDKGNDFFK 572
|
|
| TtdA |
COG1951 |
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy ... |
41-341 |
3.85e-132 |
|
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 441554 Cd Length: 289 Bit Score: 385.97 E-value: 3.85e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 41 KIEPAALTLLAQQAFHDASFMLRPAHQQQVADILSDpEASENDKYVALQFLRNSEISAKGILPTCQDTGTAIIVGKKGQN 120
Cdd:COG1951 3 EIDPEDLTEAVAELIIEASYYLPPDVLEALKEALEK-EESPNAKDVLAQILENAEIAAEGKLPICQDTGTAVVFVKIGQD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 121 VWTGGNDAEALSQGVYNTFVEDNLRYSQNAALDmykEVNTGTNLPAQIDLYSTEGEDYKFLFVTKGGGSANKTYLYqetk 200
Cdd:COG1951 82 VPIDGDLEEAINEGVRRAYKEGPLRKSVVDPLT---RKNTGDNTPAVIHIEIVPGDKLEITVAPKGGGSENKSALK---- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 201 aLLTPGK----LKSFLIEKMRSLGTAACPPYHIAFVIGGTsAETTLKTVKLASTKYYDELPTEgnehgqaFRDVALEQEI 276
Cdd:COG1951 155 -MLNPSEglegVKKFVLETVKEAGGNPCPPGIVGVGIGGT-AEKAAKLAKKALLRPLDERNPD-------PRLAELEEEL 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 746223659 277 LEAARDLGLGAQ-FGGKYFAHDVRIIRLPRHGASCPVGMGVSCSADRNIKGKINRKGVWleQLEQN 341
Cdd:COG1951 226 LEAINKLGIGPQgLGGKTTALDVKIERAPRHIASLPVAVNINCWATRHATAVIDGDGPF--ELESP 289
|
|
| Fumerase_C |
pfam05683 |
Fumarase C-terminus; This family consists of the C terminal region of several bacterial ... |
332-536 |
3.92e-131 |
|
Fumarase C-terminus; This family consists of the C terminal region of several bacterial fumarate hydratase proteins (FumA and FumB). Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth.
Pssm-ID: 461714 [Multi-domain] Cd Length: 204 Bit Score: 380.28 E-value: 3.92e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 332 GVWLEQLEQNPGKYIPEHLRETGEgDAVKIDLNRPmaEILKTLSQYPVSTRLSLTGTIIVGRDIAHAKLKERLDNGEGLP 411
Cdd:pfam05683 1 GSGPEQLEPPPLEYWPEWEEDDLA-EAVRVDLNRP--ETREELSKWPVGTRLLLSGTLLTGRDAAHKRIKEMLDKGEPLP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 412 QYIKD--HPIYYAGPAKTPEGYPSGSLGPTTAGRMDSYVDLLQANGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGpA 489
Cdd:pfam05683 78 EYVDLngRPIYYAGPVDTPGGEVVGSAGPTTATRMDKYVDDFLEKGGSMGMIGKGNRGPAVTEACKKHGGFYLGAIGG-A 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 746223659 490 AILAQNSIKSLTCVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQ 536
Cdd:pfam05683 157 AYLAAKAIKKVEVVAFEELGMEAIWEFEVEDFPAFVAVDDKGNSFHK 203
|
|
| Fumerase |
pfam05681 |
Fumarate hydratase (Fumerase); This family consists of several bacterial fumarate hydratase ... |
48-324 |
1.69e-113 |
|
Fumarate hydratase (Fumerase); This family consists of several bacterial fumarate hydratase proteins FumA and FumB. Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth. Three fumarases, FumA, FumB, and FumC, have been reported in E. coli. fumA and fumB genes are homologous and encode products of identical sizes which form thermolabile dimers of Mr 120,000. FumA and FumB are class I enzymes and are members of the iron-dependent hydrolases, which include aconitase and malate hydratase. The active FumA contains a 4Fe-4S centre, and it can be inactivated upon oxidation to give a 3Fe-4S centre.
Pssm-ID: 461713 Cd Length: 267 Bit Score: 337.46 E-value: 1.69e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 48 TLLAQQAFHDASFMLRPAHQQQVADILSDpEASENDKYVALQFLRNSEISAKGILPTCQDTGTAIIVGKKGQNVW-TGGN 126
Cdd:pfam05681 1 TEAVAELIIEASTYLPPDVLEALKKALEK-EESPNAKFVLEQILENAEIAAEEKLPICQDTGMAVVFVKIGQDVHiEGGD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 127 DAEALSQGVYNTFVEDNLRYSQNAalDMYKEVNTGTNLPAQIDLYSTEGEDYKFLFVTKGGGSANKTYLYqetkaLLTPG 206
Cdd:pfam05681 80 LEEAINEGVRRAYTEGPLRKSVVA--DPLTRKNTGDNTPAVIHIEIVPGDELKITVAPKGGGSENMSALK-----MLNPA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 207 ----KLKSFLIEKMRSLGTAACPPYHIAFVIGGTSAETTLKTVKlAStkyYDELPTEG-NEHGQafrdvALEQEILEAAR 281
Cdd:pfam05681 153 dgleGVKKFVLETVKEAGPNACPPYIVGVGIGGTFEKAALLAKK-AL---LRPLGTRNpDPRGA-----ELEEELLEAIN 223
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 746223659 282 DLGLGAQ-FGGKYFAHDVRIIRLPRHGASCPVGMGVSCSADRNI 324
Cdd:pfam05681 224 KLGIGPQgLGGKTTALDVHIERAPTHIASLPVAVNVQCWADRHA 267
|
|
| FumA |
COG1838 |
Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy ... |
361-536 |
1.19e-97 |
|
Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 441443 Cd Length: 190 Bit Score: 293.94 E-value: 1.19e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 361 IDLNRPMAEIlkTLSQYPVSTRLSLTGTIIVGRDIAHAKLKERLDNGEGLPQYIKDHPIYYAGPAKTPEGYPSGSLGPTT 440
Cdd:COG1838 4 IRLNTPLTEE--DVRKLKAGDRVLLSGTIYTARDAAHKRLVELLDRGEPLPVDLKGQVIYYVGPAPAKPGYVIGSAGPTT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 441 AGRMDSYVDLLQANGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAILAQnSIKSLTCVEYPELGMEAIWKIEVED 520
Cdd:COG1838 82 STRMDKYTPELLEELGLKGMIGKGGRSPEVIEAMKKHGAVYLAAVGGAAALLAK-AIKKVEVVAYEDLGPEAIWKLEVED 160
|
170
....*....|....*.
gi 746223659 521 FPAFILVDDKGNDFFQ 536
Cdd:COG1838 161 FPLIVAIDSKGNSLYE 176
|
|
| ttdB_fumA_fumB |
TIGR00723 |
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S ... |
374-536 |
2.30e-78 |
|
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase beta chain and the C-terminal region of the class I fumarase (where the N-terminal region is homologous to the tartrate dehydratase alpha chain). The activity of archaeal proteins in this subfamily has not been established.
Pssm-ID: 129806 Cd Length: 168 Bit Score: 243.88 E-value: 2.30e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 374 LSQYPVSTRLSLTGTIIVGRDIAHAKLKERLDNGEGLPQYIKDHPIYYAGPAKTPEGYP-SGSLGPTTAGRMDSYVDLLQ 452
Cdd:TIGR00723 3 ILKLKVGDVVYLTGTIFTARDEAHARLLELIDEGKELPFDLNGSVIYHAGPIVTKNGEWeVVSVGPTTSARMNPFEPELL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 453 ANGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAILAQnSIKSLTCVEYPELGM-EAIWKIEVEDF-PAFILVDDK 530
Cdd:TIGR00723 83 EKLGVMAIIGKGGMSKEVVEACRKYKAVYLAFPGGCAALLAQ-SVKKVEGVAWEDLGMpEAIWELEVEDFgPLIVAIDSH 161
|
....*.
gi 746223659 531 GNDFFQ 536
Cdd:TIGR00723 162 GNSIFQ 167
|
|
| PRK06842 |
PRK06842 |
Fe-S-containing hydro-lyase; |
385-539 |
4.41e-44 |
|
Fe-S-containing hydro-lyase;
Pssm-ID: 180724 [Multi-domain] Cd Length: 185 Bit Score: 154.56 E-value: 4.41e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 385 LTGTIIVGRDIAHAKLKERLDNGEGLPQYIKDHPIYYAGPAKTPEGYPSGSLGPTTAGRMDSYVDLLqANGGSMIMLAKG 464
Cdd:PRK06842 25 ISGYIYTARDAAHKRLIELLDKGEELPIDIKDQIIYYVGPSPAKPGKVIGSAGPTTSYRMDAYAPRL-LDIGLKGMIGKG 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 746223659 465 NRSQQVTDACHKHGGFYLGSIGGPAAILAQnSIKSLTCVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQVIQ 539
Cdd:PRK06842 104 ARSDEVIESIKKNKAVYFGAIGGAAALIAK-SIKKSEVIAYEDLGAEAIRKLEVKDFPVVVIIDSEGNNLYEIGQ 177
|
|
| PRK06246 |
PRK06246 |
fumarate hydratase; Provisional |
78-322 |
2.06e-37 |
|
fumarate hydratase; Provisional
Pssm-ID: 180486 Cd Length: 280 Bit Score: 139.53 E-value: 2.06e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 78 EASENDKYVALQFLRNSEISAKGILPTCQDTGTAIIVGKKGQNV-WTGGNDAEALSQGVYNTFVEDNLRysQNAALDMYK 156
Cdd:PRK06246 39 EESPIGKEILKAILENAEIAKEEQVPLCQDTGMAVVFVEIGQDVhIEGGDLEDAINEGVRKGYEEGYLR--KSVVADPLT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 157 EVNTGTNLPAQIDLYSTEGEDYKFLFVTKGGGSANKTYLyqetkALLTPG----KLKSFLIEKMRSLGTAACPPYHIAFV 232
Cdd:PRK06246 117 RKNTGDNTPAVIHTEIVPGDKLKITVAPKGGGSENMSAL-----KMLKPAdgleGIKKFVLETVKEAGGNPCPPIIVGVG 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 233 IGGTsAETTLKTVKLAstkyydelptegnehgqAFRDV----------ALEQEILEAARDLGLGAQ-FGGKYFAHDVRII 301
Cdd:PRK06246 192 IGGT-FDKAAKLAKKA-----------------LLRPIgernpdpeiaALEEELLEEINKLGIGPMgLGGKTTALDVKIE 253
|
250 260
....*....|....*....|.
gi 746223659 302 RLPRHGASCPVGMGVSCSADR 322
Cdd:PRK06246 254 TYPCHIASLPVAVNIQCHAAR 274
|
|
| ttdA_fumA_fumB |
TIGR00722 |
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region; A number of Fe-S ... |
76-322 |
3.42e-34 |
|
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region; A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase alpha chain and the N-terminal region of the class I fumarase (where the C-terminal region is homologous to the tartrate dehydratase beta chain). The activity of archaeal proteins in this subfamily has not been established.
Pssm-ID: 273234 Cd Length: 273 Bit Score: 130.27 E-value: 3.42e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 76 DPEASENDKYVALQFLRNSEISAKGILPTCQDTGTAIIVGKKGQNVWTGGNDAEALSQGVYNTFVEDNLRYSqnaALDMY 155
Cdd:TIGR00722 29 DREESEIAKINLEAILDNIEIAEKLGVPVCQDTGVPIFFVKVGSRFVLIGKLYEAIKQGVEEATEEVPLRPN---AVHPL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 156 KEVNTGTNL---PAQIDLYSTEGEDYKFLFVTKGGGSANKTYLyqetkALLTPG----KLKSFLIEKMRSLGTAACPPYH 228
Cdd:TIGR00722 106 TRENTGDNTglgVPQIHVEIVPGDELEIVVFPKGAGSENPSAL-----KMLKPSdgieGVKKFVLETVKNAGGKPCPPII 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 229 IAFVIGGTsAETTLKTVKLA-----STKYYDELPTEgnehgqafrdvaLEQEILEAARDLGLGAQ-FGGKYFAHDVRIIR 302
Cdd:TIGR00722 181 VGVGIGGS-FETAAKLAKKAllrpiGERHPNPKIAK------------LELELLEEINSLGIGPMgLGGKTTALDVKIES 247
|
250 260
....*....|....*....|
gi 746223659 303 LPRHGASCPVGMGVSCSADR 322
Cdd:TIGR00722 248 AHCHTASLPVAVNIQCWAHR 267
|
|
| PRK06043 |
PRK06043 |
fumarate hydratase; Provisional |
385-539 |
2.86e-26 |
|
fumarate hydratase; Provisional
Pssm-ID: 180366 Cd Length: 192 Bit Score: 106.00 E-value: 2.86e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 385 LTGTIIVGRDIAHAKLKERLDNGEGLPQYIKDHPIYYAGP--AKTPEGYPSGSLGPTTAGRMDSYVDLLQANGGSMIMLA 462
Cdd:PRK06043 25 ISGEILTARDEAHARILEMKEKGKELPFSLEGAVIYHCGPlmKKTDEGWKVVSAGPTTSARMSKMTPKLLEKVEVRAIIG 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 746223659 463 KGNRsQQVTDAChKHGGFYLGSIGGPAAiLAQNSIKSLTCVEYPELGM-EAIWKIEVEDF-PAFILVDDKGNDFFQVIQ 539
Cdd:PRK06043 105 KGGM-KNVADAL-KGKCVYLAYTGGCAA-LAAESIKRVKAVHWLDLGMpEAVWVLEVEEFgPLIVGIDAKGNDLYSEVR 180
|
|
| PRK08228 |
PRK08228 |
L(+)-tartrate dehydratase subunit beta; Validated |
385-536 |
3.86e-21 |
|
L(+)-tartrate dehydratase subunit beta; Validated
Pssm-ID: 236192 Cd Length: 204 Bit Score: 91.66 E-value: 3.86e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 385 LTGTIIVGRDIAHAKLKERldnGEGLPQYIKDHPIYYAGP----AKTPEGYPSGSLGPTTAGRMDSYVDLLQANGGSMIM 460
Cdd:PRK08228 26 LTGTLVTCRDVAHRRLIEL---GRELPVDLNGGAIFHAGPivrpKKNDDKFEMVSVGPTTSMRMEKFEKEFIEQTGVKLI 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 746223659 461 LAKGNRSQQVTDACHKHGGFYLGSIGGpAAILAQNSIKSLTCVEYPELGM-EAIWKIEVEDF-PAFILVDDKGNDFFQ 536
Cdd:PRK08228 103 VGKGGMGPGTEEGCQEFKALHCVFPAG-CAVLAATQVEEIEDAQWRDLGMpETLWVCRVKEFgPLIVSIDTHGNNLFE 179
|
|
| PRK08395 |
PRK08395 |
fumarate hydratase; Provisional |
379-536 |
5.26e-16 |
|
fumarate hydratase; Provisional
Pssm-ID: 169425 Cd Length: 162 Bit Score: 75.62 E-value: 5.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 379 VSTRLSLTGTIIVGRDIAHAKLKErldngEGLPQYIKDHPIYYAGPAKTPEGYPSGslGPTTAGRMDSYVDLLQANGGSM 458
Cdd:PRK08395 17 AGDVVYLSGIIYTARDLAHRRFLS-----EGFPFNPEGAVIYHCGPLVKNKKIVSA--GPTTSARMNKYLDFLFSLGVRG 89
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 746223659 459 IMLAKGNRSQQVtdachKHGGFYLGSIGGpAAILAQNSIKSLTCVEYPELGM-EAIWKIEVEDFPAFILVDDKGNDFFQ 536
Cdd:PRK08395 90 IIGKGGMNAEPF-----KGRAVYFAFPGG-AGSLAAKSIKRVRDVYWEDLGMpDAVWELEVEDFPLLVAIDSKGRSLYR 162
|
|
| PRK08230 |
PRK08230 |
tartrate dehydratase subunit alpha; Validated |
74-329 |
8.31e-12 |
|
tartrate dehydratase subunit alpha; Validated
Pssm-ID: 181309 Cd Length: 299 Bit Score: 66.27 E-value: 8.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 74 LSDPEASENDKYVALQFLRNSEISAKGILPTCQDTGTAIIVGKKGQNVWTGGNDAEALSQGVYNTFVEDNLRYSqnaALD 153
Cdd:PRK08230 36 LKDAETSPLAKIIYDTMFENQQLAIDLNRPSCQDTGVIQFFVKVGARFPLLGELESILKEAVEEATVKAPLRHN---AVE 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 154 MYKEVNTGTNLPAQIDLYSTE---GEDYKFLFVTKGGGSANktyLYQETKALLtPGK----LKSFLIEKMRSLGTAACPP 226
Cdd:PRK08230 113 TFDEYNTGKNTGSGVPWVFWEivpDSDDAEIEVYMAGGGCT---LPGRAKVLM-PGEgyegVVKFVFDVITSYGVNACPP 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746223659 227 YHIAFVIgGTSAETTLKTVKLASTKyydelPTeGNEHGQAfRDVALEQEILEAARDLGLGAQ-FGGKYFAHDVRIIRLPR 305
Cdd:PRK08230 189 LLVGVGI-ATSVETAAVLSKKAILR-----PI-GSRNPNP-RAAELEKRLEEGLNRIGLGPQgLTGNSSVMGVNIESAAR 260
|
250 260
....*....|....*....|....
gi 746223659 306 HGASCPVGMGVSCSADRniKGKIN 329
Cdd:PRK08230 261 HPSTIGVAVSTGCWAHR--RGTIV 282
|
|
| |
