|
Name |
Accession |
Description |
Interval |
E-value |
| dnaE |
PRK05673 |
DNA polymerase III subunit alpha; Validated |
5-1152 |
0e+00 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 235554 [Multi-domain] Cd Length: 1135 Bit Score: 2129.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 5 RFVHLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADFCVES-----DELGD 79
Cdd:PRK05673 1 RFVHLHVHSEYSLLDGAAKIKPLVKKAAELGMPAVALTDHGNLFGAVEFYKAAKGAGIKPIIGCEAYVAPekkddVSGGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 80 ELAHLTVLAMNNAGYQNLTLLISHAYQRGYGAAGPTIDRDWLVEHQEGLILLSGGRRGDVGRFLLRGNQTQAEQCLAFYQ 159
Cdd:PRK05673 81 AYTHLTLLAKNETGYRNLFKLSSRAYLEGQYGYKPRIDREWLAEHSEGLIALSGCPSGEVGTALLAGQYDEAEEAAAEYQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 160 EHFPQRYYLELIRTSRPDEESYLHAAVELATKHGVPVVATNEVCFISTDDFDAHEIRVAIHDGYTLDDPKRPRNYSPQQY 239
Cdd:PRK05673 161 EIFGDRFYLELMRHGLPIERRVEHALLELAKELGLPLVATNDVHYLTPEDAEAHEALLCIAEGKTLDDPDRFRFYSPEQY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 240 MRSEEEMCELFADIPEALANSVEIAKRCNVTIRLGEYFLPQFPTGDMSTE-DFLVQCSKKGLEERLEFLFPDpevraERR 318
Cdd:PRK05673 241 LKSAEEMRELFADLPEALDNTVEIAERCNVEVRLGKPFLPRFPTPDGETEeDYLRKEAKEGLEERLAFLFPD-----EER 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 319 PEYDERLDIELGVINQMGFPGYFLIVMEFIQWSKDNDVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVS 398
Cdd:PRK05673 316 PEYVERLEYELDVIIQMGFPGYFLIVADFIQWAKDNGIPVGPGRGSGAGSLVAYALGITDLDPLRFGLLFERFLNPERVS 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 399 MPDFDVDFCMEKRDKVIDHVAEMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPGMTLEKAFAAE 478
Cdd:PRK05673 396 MPDFDIDFCQDRRDEVIRYVAEKYGRDAVAQIITFGTMKAKAVIRDVGRVLGMPYGFVDRITKLIPPDPGITLAKAYEEE 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 479 PQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVISPTKITDFAPLYCDAEGNHPVTQFDKNDVEYAGLVKFDFLG 558
Cdd:PRK05673 476 PELRELYESDPEVKRLIDMARKLEGLTRNAGVHAAGVVISPTPLTDFVPLYRDPDSGMPVTQFDMKDVEAAGLVKFDFLG 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 559 LRTLTIIDWALGMINARRAkqglEPIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVALF 638
Cdd:PRK05673 556 LRTLTIIDDALKLIKKRRG----IDVDLEAIPLDDPKTYELLQRGETLGVFQLESRGMRDLLKRLKPDCFEDIIALVALY 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 639 RPGPLQSGMVDNFIDRKHGREAISYPdiewqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGKKNPV 718
Cdd:PRK05673 632 RPGPMESGMIPNFIDRKHGREEIEYP-----HPELEPILKETYGIIVYQEQVMQIAQVLAGYSLGGADLLRRAMGKKKPE 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 719 EMAKQRGGFEDGAKSRGVNGELAVKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTDKVV 798
Cdd:PRK05673 707 EMAKQREIFVEGAKKNGIDEEAADAIFDLLEKFAGYGFNKSHAAAYALVSYQTAYLKAHYPAEFMAALLTSDMDNTDKVA 786
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 799 GLVDECWRMGLKILPPDINSGLYHFHVnDDGEIVYGIGAIKGVGEGPIEAIIEARNQGGYFRELFDLCARTDIKKLNRRV 878
Cdd:PRK05673 787 VYLDECRRMGIKVLPPDVNESLYDFTV-VDGDIRYGLGAIKGVGEGAVEAIVEAREEGGPFKDLFDFCARVDLKKVNKRV 865
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 879 LEKLIMSGAFDRLGPHRAALMNSLPDALKAADQHAKAEAIGQVDMFGVLADAPEQVEQSYSTVPPWPEQVVLDGERETLG 958
Cdd:PRK05673 866 LESLIKAGAFDSLGPNRAALLASLEDAVDAADQHKKAEASGQFDLFGGLGEEPEDVEVSVPDVEEWDKKEKLAGERETLG 945
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 959 LYLTGHPITQYIKEIERYAgGVRLKDMHPTDRGKMTTAVGLVLAARVMVTKRGNRIGVCTLDDRSGRLEIMLFTDALEKY 1038
Cdd:PRK05673 946 LYLSGHPLDGYEDELRRLR-DTRLADLEPTEGGSVVTVAGLVVSVRRRVTKRGNKMAIVTLEDLSGRIEVMLFSEALEKY 1024
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 1039 QHLLEKDRILIASGQVSFDDfsGGLKMTVRELMDISEAREKYARGLAISLTDRQIDDQLLNRLRQSLEPHRsGTIPVHLY 1118
Cdd:PRK05673 1025 RDLLEEDRIVVVKGQVSFDD--GGLRLTAREVMDLEEARAKYARPLRISLPDRQLTPQLLERLKQVLEPHR-GTSPVHLY 1101
|
1130 1140 1150
....*....|....*....|....*....|....
gi 746426554 1119 YQREDARARLRFGAAWRVTPADALLNELRTLVGN 1152
Cdd:PRK05673 1102 LQDPDAEAELRLGDRWRVTPSDALLGDLKALLGV 1135
|
|
| DnaE |
COG0587 |
DNA polymerase III, alpha subunit [Replication, recombination and repair]; |
1-1071 |
0e+00 |
|
DNA polymerase III, alpha subunit [Replication, recombination and repair];
Pssm-ID: 440352 [Multi-domain] Cd Length: 1050 Bit Score: 1689.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 1 MAePRFVHLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADFCVESDELGDE 80
Cdd:COG0587 1 MS-PSFVHLHVHSEYSLLDGASRPEELVARAAELGMPALAITDHGNLFGAVRFYKAAKKAGIKPIIGCELYVAPGSRDDA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 81 LAHLTVLAMNNAGYQNLTLLISHAYQRGYGAAGPTIDRDWLVEHQEGLILLSGGRRGDVGRFLLRGNQTQAEQCLAFYQE 160
Cdd:COG0587 80 GYHLVLLAKNREGYRNLCRLLSRAYLEGFYKGKPRIDLEDLAEHSEGLIALSGCLAGEVGQALLAGQYDEAEAALARLKD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 161 HFPQRYYLELIRTSRPDEESYLHAAVELATKHGVPVVATNEVCFISTDDFDAHEIRVAIHDGYTLDDPKRPRNYSPQQYM 240
Cdd:COG0587 160 IFGDRFYLELQRHGLPEDRRVNAALLELARELGLPLVATNDVHYLNPEDAEAHDVLLCIRTGKTLDDPGRRRFANAERYL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 241 RSEEEMCELFADIPEALANSVEIAKRCNVTIRLGEYFLPQFPTGD-MSTEDFLVQCSKKGLEERLEFLfpdpevraeRRP 319
Cdd:COG0587 240 KSPEEMAELFADLPEALANTLEIAERCNFSLDLGKYQLPKFPVPEgETEEEYLRKLAEEGLERRYPEG---------IPE 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 320 EYDERLDIELGVINQMGFPGYFLIVMEFIQWSKDNDVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSM 399
Cdd:COG0587 311 EYRERLEYELDVIEKMGFPGYFLIVWDFIRWARSNGIPVGPGRGSAAGSLVAYALGITDVDPIRYDLLFERFLNPERVSM 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 400 PDFDVDFCMEKRDKVIDHVAEMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPGMTLEKAFAAEP 479
Cdd:COG0587 391 PDIDIDFCHERREEVIQYVYEKYGRDRVAQIATFGTMRARAAIRDVGRVLGLPYGEVDRLAKLIPNDPGITLEKALEEEP 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 480 QLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVISPTKITDFAPLYCDAEGNHPVTQFDKNDVEYAGLVKFDFLGL 559
Cdd:COG0587 471 ELRELYDSDPEVRRLLDLARKLEGLPRHLSTHAGGVVISDDPLTDLVPLERAAMGGRPVTQFDKDDVEALGLLKFDFLGL 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 560 RTLTIIDWALGMINARRAkqglEPIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVALFR 639
Cdd:COG0587 551 RTLTVIRDALDLIKENRG----IDIDLADIPLDDPKTYELLQRGDTIGVFQLESRGMRSLLKRLKPDCFEDLVALVALYR 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 640 PGPLQSGMVDNFIDRKHGREAISYPdiewqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGKKNPVE 719
Cdd:COG0587 627 PGPMQGGMVPPYIRRKHGREPVEYP-----HPELEPILKETYGVIVYQEQVMQIAQVLAGFSLGEADLLRRAMGKKKKEE 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 720 MAKQRGGFEDGAKSRGVNGELAVKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTDKVVG 799
Cdd:COG0587 702 MAKQREKFVEGAVANGYDEEFAEEIFDQIEKFAGYGFNKSHAAAYALLAYQTAYLKAHYPAEFMAALLNSQPMGFYKPAQ 781
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 800 LVDECWRMGLKILPPDINSGLYHFHVNDDGEIVYGIGAIKGVGEGPIEAIIEARNQGGYFRELFDLCARTDIKKLNRRVL 879
Cdd:COG0587 782 YVQEARRHGIEVLPPDVNESDWDFTVEPGGAIRLGLGAIKGVGEAAAEAIVAAREENGPFTSLFDFCRRVDLRKLNKRVL 861
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 880 EKLIMSGAFDRLGPHRAALMNSLPDALKAADQHAKAEAIGQVDMFGvLADAPEQVEQSYSTVPPWPEQVVLDGERETLGL 959
Cdd:COG0587 862 EALIKAGAFDSLGPNRRQLLWALEAALDAAQQAQKDKASGQLSLFG-GAGDEEVAEPALPELPEWSEKEKLAAEKEALGL 940
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 960 YLTGHPITQYIKEIERYaGGVRLKDMHPTDRGKMTTAVGLVLAARVMVTKRGNRIGVCTLDDRSGRLEIMLFTDALEKYQ 1039
Cdd:COG0587 941 YLSGHPLDLYREELRRL-GVTPAADLAELRDGRRVRVAGLVTSRQRPGTKKGKRMAFVTLEDETGSIEVVVFPEVYERYR 1019
|
1050 1060 1070
....*....|....*....|....*....|..
gi 746426554 1040 HLLEKDRILIASGQVSFDDfsGGLKMTVRELM 1071
Cdd:COG0587 1020 RLLLEDRLLLVRGKVQRRD--GVVHLIAERIE 1049
|
|
| polc |
TIGR00594 |
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are ... |
6-1031 |
0e+00 |
|
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are known are DNA polymerases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273161 [Multi-domain] Cd Length: 1022 Bit Score: 1592.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 6 FVHLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADFCVESD--------EL 77
Cdd:TIGR00594 1 FVHLHVHSDYSLLDGAAKIKPLVKKAKELGMPALALTDHGNMFGAVEFYKACKKAGIKPIIGCEAYVAPGsrfdkkriSK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 78 GDELAHLTVLAMNNAGYQNLTLLISHAYQRGYGAaGPTIDRDWLVEHQEGLILLSGGRRGDVGRFLLRGNQTQAEQCLAF 157
Cdd:TIGR00594 81 GKEAYHLILLAKNNTGYRNLMKLSSLAYLEGFYY-KPRIDKELLEEHSEGLIALSACLSGEVPYLLLLGEERLAEEAALK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 158 YQEHFPQRYYLELIRTSRPDEESYLHAAVELATKHGVPVVATNEVCFISTDDFDAHEIRVAIHDGYTLDDPKRPRNYSPQ 237
Cdd:TIGR00594 160 YQEIFGDDYYLELQDHGIPEQRVVNEALLEISEELGIPLVATNDVHYINPEDAHAHEILLCIQTGKTLSDPKRLKFYSDE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 238 QYMRSEEEMCELFADIPEALANSVEIAKRCN-VTIRLGEYFLP--QFPTGDMSTEDFLVQCSKKGLEERLEFLFPdpevR 314
Cdd:TIGR00594 240 FYLKSPEEMAELFADIPEALANTVEIAERCNlVDVKLGPPRLPsyQIPPDFTSQEDYLRHLADEGLRERLAAGPP----G 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 315 AERRPEYDERLDIELGVINQMGFPGYFLIVMEFIQWSKDNDVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNP 394
Cdd:TIGR00594 316 YKRRAQYKERLEYELDVINSMGFPGYFLIVWDFIKWAKDHGIPVGPGRGSAAGSLVAYALKITDIDPIKHGLLFERFLNP 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 395 ERVSMPDFDVDFCMEKRDKVIDHVAEMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPGMTLEKA 474
Cdd:TIGR00594 396 ERISMPDIDIDFCDERRDEVIEYVADKYGHDNVAQIITFGTMKAKAALRDVARVLDIPYAEADRIAKLIPPRPGKTLKEA 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 475 FAAEPQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVISPTKITDFAPLYCDAEGNHPVTQFDKNDVEYAGLVKF 554
Cdd:TIGR00594 476 LEASPQLRQLYEEDPEVKQLIDMARKLEGLNRNAGVHAAGVVISSEPLTDYVPLYKDKEGGAISTQYDMDDLEAVGLLKM 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 555 DFLGLRTLTIIDWALGMINARRAKqglePIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIAL 634
Cdd:TIGR00594 556 DFLGLKTLTLIQDATELIRKRRGI----DLDIASIPLDDKKTFSLLQEGDTTGVFQLESRGMQDLLKRLKPDGFEDIIAV 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 635 VALFRPGPLQSGMVDNFIDRKHGREAISYPdiewqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGK 714
Cdd:TIGR00594 632 NALYRPGPMESGMIPDFIDRKHGREPIEYP-----HPLLEPILKETYGVIVYQEQVMQIAQRLAGFSLGEADLLRRAMGK 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 715 KNPVEMAKQRGGFEDGAKSRGVNGELAVKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNT 794
Cdd:TIGR00594 707 KKAEEMAKEREKFVEGAEKNGYDPEIAENLFDLIEKFAGYGFNKSHAAAYGMISYQTAYLKANYPAEFMAALLTSEINDI 786
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 795 DKVVGLVDECWRMGLKILPPDINSGLYHFHVNDDGeIVYGIGAIKGVGEGPIEAIIEARNQGGYFRELFDLCARTDIKKL 874
Cdd:TIGR00594 787 EKVAVYIAEAKKMGIEVLPPDINESGQDFAVEDKG-IRYGLGAIKGVGESVVKSIIEERNKNGPFKSLFDFINRVDFKKL 865
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 875 NRRVLEKLIMSGAFDRLGPHRAALMNSLPDALKAADQHAKAEAIGQVDMFGVLADAPEQVEQSYSTVPPWPEQVVLDGER 954
Cdd:TIGR00594 866 NKKVLEALIKAGAFDSLGPNRKTLLASLDDALDAVSRKKKAEALGQNSLFGALSEGTKPEYVFFPPDEEWPDKKLLALEK 945
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 746426554 955 ETLGLYLTGHPITQYIKEIERYAGGVRLKDMHPTDRGKMTTAVGLVLAARVMVTKRGNRIGVCTLDDRSGRLEIMLF 1031
Cdd:TIGR00594 946 ETLGLYVSGHPLDAYEKALKNTATPAAIEDLEAPNDSQVRTLGGLNSVKKKITTKNGKPMAFLQLEDETGSIEVVVF 1022
|
|
| PHP_PolIIIA_DnaE1 |
cd07433 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
5-281 |
3.49e-171 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes.
Pssm-ID: 213988 [Multi-domain] Cd Length: 277 Bit Score: 505.09 E-value: 3.49e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 5 RFVHLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADFCVESDELGDELAHL 84
Cdd:cd07433 1 SFVHLRVHSEYSLLDGAVRIKKLVKLAKEDGMPALAITDLSNLFGAVKFYKAASKAGIKPIIGADLNVANPDDADEPFRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 85 TVLAMNNAGYQNLTLLISHAYQRGYGAAGPTIDRDWLVEHQEGLILLSGGRRGDVGRFLLRGNQTQAEQCLAFYQEHFPQ 164
Cdd:cd07433 81 TLLAQNEQGYKNLTELISRAYLEGQRNGGPHIKLEWLAEYSEGLIALSGGRDGDIGQLLLEGNPDLAEALLQFLKKIFPD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 165 RYYLELIRTSRPDEESYLHAAVELATKHGVPVVATNEVCFISTDDFDAHEIRVAIHDGYTLDDPKRPRNYSPQQYMRSEE 244
Cdd:cd07433 161 RFYLELQRHGRPEEEAYEHALIDLAYELGLPLVATNDVRFLKPEDFEAHEARVCIAEGRTLDDPRRPRRYSPQQYFKSAE 240
|
250 260 270
....*....|....*....|....*....|....*..
gi 746426554 245 EMCELFADIPEALANSVEIAKRCNVTIRLGEYFLPQF 281
Cdd:cd07433 241 EMAELFADLPEAIENTVEIAKRCNVRIELGKPFLPDF 277
|
|
| DNA_pol3_alpha |
pfam07733 |
Bacterial DNA polymerase III alpha NTPase domain; |
290-558 |
1.22e-139 |
|
Bacterial DNA polymerase III alpha NTPase domain;
Pssm-ID: 400196 [Multi-domain] Cd Length: 259 Bit Score: 422.30 E-value: 1.22e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 290 DFLVQCSKKGLEERLeflfpdpevRAERRPEYDERLDIELGVINQMGFPGYFLIVMEFIQWSKDNDVPVGPGRGSGAGSL 369
Cdd:pfam07733 1 EYLRKLVEEGLKERY---------GEGLPEEYQERLEYELNVIIKMGFAGYFLIVWDLVKWAKDNGILVGPGRGSAAGSL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 370 VAYALKITDLDPLEFDLLFERFLNPERVSMPDFDVDFCMEKRDKVIDHVAEMYGRDAVSQIITFGTMAAKAVIRDVGRVL 449
Cdd:pfam07733 72 VAYLLGITEVDPLKHDLLFERFLNPERVSMPDIDIDFEDERREEVIDYVKEKYGRDRVAQIATFGTYAAKSAIRDVGRAL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 450 GHPYGFVDRISKLVPPDPGMtLEKAFAAEPQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVISPTKITDFAPLY 529
Cdd:pfam07733 152 GLPYDEIDRLAKLIPFELGI-LEKALEEEPELKELIESDPEVKRLIELAKKLEGLPRHTGQHAGGVVISPDPLTDFVPLY 230
|
250 260
....*....|....*....|....*....
gi 746426554 530 CDAEGNHPVTQFDKNDVEYAGLVKFDFLG 558
Cdd:pfam07733 231 KADDDDRPVTQFDKDDLEDLGLLKMDFLG 259
|
|
| POLIIIAc |
smart00481 |
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family ... |
8-70 |
1.28e-21 |
|
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family of hypothetical proteins
Pssm-ID: 197753 [Multi-domain] Cd Length: 67 Bit Score: 89.25 E-value: 1.28e-21
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 746426554 8 HLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADF 70
Cdd:smart00481 1 DLHVHSDYSLLDGALSPEELVKRAKELGLKAIAITDHGNLFGAVEFYKAAKKAGIKPIIGLEA 63
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| dnaE |
PRK05673 |
DNA polymerase III subunit alpha; Validated |
5-1152 |
0e+00 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 235554 [Multi-domain] Cd Length: 1135 Bit Score: 2129.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 5 RFVHLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADFCVES-----DELGD 79
Cdd:PRK05673 1 RFVHLHVHSEYSLLDGAAKIKPLVKKAAELGMPAVALTDHGNLFGAVEFYKAAKGAGIKPIIGCEAYVAPekkddVSGGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 80 ELAHLTVLAMNNAGYQNLTLLISHAYQRGYGAAGPTIDRDWLVEHQEGLILLSGGRRGDVGRFLLRGNQTQAEQCLAFYQ 159
Cdd:PRK05673 81 AYTHLTLLAKNETGYRNLFKLSSRAYLEGQYGYKPRIDREWLAEHSEGLIALSGCPSGEVGTALLAGQYDEAEEAAAEYQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 160 EHFPQRYYLELIRTSRPDEESYLHAAVELATKHGVPVVATNEVCFISTDDFDAHEIRVAIHDGYTLDDPKRPRNYSPQQY 239
Cdd:PRK05673 161 EIFGDRFYLELMRHGLPIERRVEHALLELAKELGLPLVATNDVHYLTPEDAEAHEALLCIAEGKTLDDPDRFRFYSPEQY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 240 MRSEEEMCELFADIPEALANSVEIAKRCNVTIRLGEYFLPQFPTGDMSTE-DFLVQCSKKGLEERLEFLFPDpevraERR 318
Cdd:PRK05673 241 LKSAEEMRELFADLPEALDNTVEIAERCNVEVRLGKPFLPRFPTPDGETEeDYLRKEAKEGLEERLAFLFPD-----EER 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 319 PEYDERLDIELGVINQMGFPGYFLIVMEFIQWSKDNDVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVS 398
Cdd:PRK05673 316 PEYVERLEYELDVIIQMGFPGYFLIVADFIQWAKDNGIPVGPGRGSGAGSLVAYALGITDLDPLRFGLLFERFLNPERVS 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 399 MPDFDVDFCMEKRDKVIDHVAEMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPGMTLEKAFAAE 478
Cdd:PRK05673 396 MPDFDIDFCQDRRDEVIRYVAEKYGRDAVAQIITFGTMKAKAVIRDVGRVLGMPYGFVDRITKLIPPDPGITLAKAYEEE 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 479 PQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVISPTKITDFAPLYCDAEGNHPVTQFDKNDVEYAGLVKFDFLG 558
Cdd:PRK05673 476 PELRELYESDPEVKRLIDMARKLEGLTRNAGVHAAGVVISPTPLTDFVPLYRDPDSGMPVTQFDMKDVEAAGLVKFDFLG 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 559 LRTLTIIDWALGMINARRAkqglEPIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVALF 638
Cdd:PRK05673 556 LRTLTIIDDALKLIKKRRG----IDVDLEAIPLDDPKTYELLQRGETLGVFQLESRGMRDLLKRLKPDCFEDIIALVALY 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 639 RPGPLQSGMVDNFIDRKHGREAISYPdiewqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGKKNPV 718
Cdd:PRK05673 632 RPGPMESGMIPNFIDRKHGREEIEYP-----HPELEPILKETYGIIVYQEQVMQIAQVLAGYSLGGADLLRRAMGKKKPE 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 719 EMAKQRGGFEDGAKSRGVNGELAVKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTDKVV 798
Cdd:PRK05673 707 EMAKQREIFVEGAKKNGIDEEAADAIFDLLEKFAGYGFNKSHAAAYALVSYQTAYLKAHYPAEFMAALLTSDMDNTDKVA 786
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 799 GLVDECWRMGLKILPPDINSGLYHFHVnDDGEIVYGIGAIKGVGEGPIEAIIEARNQGGYFRELFDLCARTDIKKLNRRV 878
Cdd:PRK05673 787 VYLDECRRMGIKVLPPDVNESLYDFTV-VDGDIRYGLGAIKGVGEGAVEAIVEAREEGGPFKDLFDFCARVDLKKVNKRV 865
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 879 LEKLIMSGAFDRLGPHRAALMNSLPDALKAADQHAKAEAIGQVDMFGVLADAPEQVEQSYSTVPPWPEQVVLDGERETLG 958
Cdd:PRK05673 866 LESLIKAGAFDSLGPNRAALLASLEDAVDAADQHKKAEASGQFDLFGGLGEEPEDVEVSVPDVEEWDKKEKLAGERETLG 945
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 959 LYLTGHPITQYIKEIERYAgGVRLKDMHPTDRGKMTTAVGLVLAARVMVTKRGNRIGVCTLDDRSGRLEIMLFTDALEKY 1038
Cdd:PRK05673 946 LYLSGHPLDGYEDELRRLR-DTRLADLEPTEGGSVVTVAGLVVSVRRRVTKRGNKMAIVTLEDLSGRIEVMLFSEALEKY 1024
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 1039 QHLLEKDRILIASGQVSFDDfsGGLKMTVRELMDISEAREKYARGLAISLTDRQIDDQLLNRLRQSLEPHRsGTIPVHLY 1118
Cdd:PRK05673 1025 RDLLEEDRIVVVKGQVSFDD--GGLRLTAREVMDLEEARAKYARPLRISLPDRQLTPQLLERLKQVLEPHR-GTSPVHLY 1101
|
1130 1140 1150
....*....|....*....|....*....|....
gi 746426554 1119 YQREDARARLRFGAAWRVTPADALLNELRTLVGN 1152
Cdd:PRK05673 1102 LQDPDAEAELRLGDRWRVTPSDALLGDLKALLGV 1135
|
|
| DnaE |
COG0587 |
DNA polymerase III, alpha subunit [Replication, recombination and repair]; |
1-1071 |
0e+00 |
|
DNA polymerase III, alpha subunit [Replication, recombination and repair];
Pssm-ID: 440352 [Multi-domain] Cd Length: 1050 Bit Score: 1689.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 1 MAePRFVHLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADFCVESDELGDE 80
Cdd:COG0587 1 MS-PSFVHLHVHSEYSLLDGASRPEELVARAAELGMPALAITDHGNLFGAVRFYKAAKKAGIKPIIGCELYVAPGSRDDA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 81 LAHLTVLAMNNAGYQNLTLLISHAYQRGYGAAGPTIDRDWLVEHQEGLILLSGGRRGDVGRFLLRGNQTQAEQCLAFYQE 160
Cdd:COG0587 80 GYHLVLLAKNREGYRNLCRLLSRAYLEGFYKGKPRIDLEDLAEHSEGLIALSGCLAGEVGQALLAGQYDEAEAALARLKD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 161 HFPQRYYLELIRTSRPDEESYLHAAVELATKHGVPVVATNEVCFISTDDFDAHEIRVAIHDGYTLDDPKRPRNYSPQQYM 240
Cdd:COG0587 160 IFGDRFYLELQRHGLPEDRRVNAALLELARELGLPLVATNDVHYLNPEDAEAHDVLLCIRTGKTLDDPGRRRFANAERYL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 241 RSEEEMCELFADIPEALANSVEIAKRCNVTIRLGEYFLPQFPTGD-MSTEDFLVQCSKKGLEERLEFLfpdpevraeRRP 319
Cdd:COG0587 240 KSPEEMAELFADLPEALANTLEIAERCNFSLDLGKYQLPKFPVPEgETEEEYLRKLAEEGLERRYPEG---------IPE 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 320 EYDERLDIELGVINQMGFPGYFLIVMEFIQWSKDNDVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSM 399
Cdd:COG0587 311 EYRERLEYELDVIEKMGFPGYFLIVWDFIRWARSNGIPVGPGRGSAAGSLVAYALGITDVDPIRYDLLFERFLNPERVSM 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 400 PDFDVDFCMEKRDKVIDHVAEMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPGMTLEKAFAAEP 479
Cdd:COG0587 391 PDIDIDFCHERREEVIQYVYEKYGRDRVAQIATFGTMRARAAIRDVGRVLGLPYGEVDRLAKLIPNDPGITLEKALEEEP 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 480 QLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVISPTKITDFAPLYCDAEGNHPVTQFDKNDVEYAGLVKFDFLGL 559
Cdd:COG0587 471 ELRELYDSDPEVRRLLDLARKLEGLPRHLSTHAGGVVISDDPLTDLVPLERAAMGGRPVTQFDKDDVEALGLLKFDFLGL 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 560 RTLTIIDWALGMINARRAkqglEPIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVALFR 639
Cdd:COG0587 551 RTLTVIRDALDLIKENRG----IDIDLADIPLDDPKTYELLQRGDTIGVFQLESRGMRSLLKRLKPDCFEDLVALVALYR 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 640 PGPLQSGMVDNFIDRKHGREAISYPdiewqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGKKNPVE 719
Cdd:COG0587 627 PGPMQGGMVPPYIRRKHGREPVEYP-----HPELEPILKETYGVIVYQEQVMQIAQVLAGFSLGEADLLRRAMGKKKKEE 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 720 MAKQRGGFEDGAKSRGVNGELAVKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTDKVVG 799
Cdd:COG0587 702 MAKQREKFVEGAVANGYDEEFAEEIFDQIEKFAGYGFNKSHAAAYALLAYQTAYLKAHYPAEFMAALLNSQPMGFYKPAQ 781
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 800 LVDECWRMGLKILPPDINSGLYHFHVNDDGEIVYGIGAIKGVGEGPIEAIIEARNQGGYFRELFDLCARTDIKKLNRRVL 879
Cdd:COG0587 782 YVQEARRHGIEVLPPDVNESDWDFTVEPGGAIRLGLGAIKGVGEAAAEAIVAAREENGPFTSLFDFCRRVDLRKLNKRVL 861
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 880 EKLIMSGAFDRLGPHRAALMNSLPDALKAADQHAKAEAIGQVDMFGvLADAPEQVEQSYSTVPPWPEQVVLDGERETLGL 959
Cdd:COG0587 862 EALIKAGAFDSLGPNRRQLLWALEAALDAAQQAQKDKASGQLSLFG-GAGDEEVAEPALPELPEWSEKEKLAAEKEALGL 940
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 960 YLTGHPITQYIKEIERYaGGVRLKDMHPTDRGKMTTAVGLVLAARVMVTKRGNRIGVCTLDDRSGRLEIMLFTDALEKYQ 1039
Cdd:COG0587 941 YLSGHPLDLYREELRRL-GVTPAADLAELRDGRRVRVAGLVTSRQRPGTKKGKRMAFVTLEDETGSIEVVVFPEVYERYR 1019
|
1050 1060 1070
....*....|....*....|....*....|..
gi 746426554 1040 HLLEKDRILIASGQVSFDDfsGGLKMTVRELM 1071
Cdd:COG0587 1020 RLLLEDRLLLVRGKVQRRD--GVVHLIAERIE 1049
|
|
| polc |
TIGR00594 |
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are ... |
6-1031 |
0e+00 |
|
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are known are DNA polymerases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273161 [Multi-domain] Cd Length: 1022 Bit Score: 1592.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 6 FVHLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADFCVESD--------EL 77
Cdd:TIGR00594 1 FVHLHVHSDYSLLDGAAKIKPLVKKAKELGMPALALTDHGNMFGAVEFYKACKKAGIKPIIGCEAYVAPGsrfdkkriSK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 78 GDELAHLTVLAMNNAGYQNLTLLISHAYQRGYGAaGPTIDRDWLVEHQEGLILLSGGRRGDVGRFLLRGNQTQAEQCLAF 157
Cdd:TIGR00594 81 GKEAYHLILLAKNNTGYRNLMKLSSLAYLEGFYY-KPRIDKELLEEHSEGLIALSACLSGEVPYLLLLGEERLAEEAALK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 158 YQEHFPQRYYLELIRTSRPDEESYLHAAVELATKHGVPVVATNEVCFISTDDFDAHEIRVAIHDGYTLDDPKRPRNYSPQ 237
Cdd:TIGR00594 160 YQEIFGDDYYLELQDHGIPEQRVVNEALLEISEELGIPLVATNDVHYINPEDAHAHEILLCIQTGKTLSDPKRLKFYSDE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 238 QYMRSEEEMCELFADIPEALANSVEIAKRCN-VTIRLGEYFLP--QFPTGDMSTEDFLVQCSKKGLEERLEFLFPdpevR 314
Cdd:TIGR00594 240 FYLKSPEEMAELFADIPEALANTVEIAERCNlVDVKLGPPRLPsyQIPPDFTSQEDYLRHLADEGLRERLAAGPP----G 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 315 AERRPEYDERLDIELGVINQMGFPGYFLIVMEFIQWSKDNDVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNP 394
Cdd:TIGR00594 316 YKRRAQYKERLEYELDVINSMGFPGYFLIVWDFIKWAKDHGIPVGPGRGSAAGSLVAYALKITDIDPIKHGLLFERFLNP 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 395 ERVSMPDFDVDFCMEKRDKVIDHVAEMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPGMTLEKA 474
Cdd:TIGR00594 396 ERISMPDIDIDFCDERRDEVIEYVADKYGHDNVAQIITFGTMKAKAALRDVARVLDIPYAEADRIAKLIPPRPGKTLKEA 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 475 FAAEPQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVISPTKITDFAPLYCDAEGNHPVTQFDKNDVEYAGLVKF 554
Cdd:TIGR00594 476 LEASPQLRQLYEEDPEVKQLIDMARKLEGLNRNAGVHAAGVVISSEPLTDYVPLYKDKEGGAISTQYDMDDLEAVGLLKM 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 555 DFLGLRTLTIIDWALGMINARRAKqglePIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIAL 634
Cdd:TIGR00594 556 DFLGLKTLTLIQDATELIRKRRGI----DLDIASIPLDDKKTFSLLQEGDTTGVFQLESRGMQDLLKRLKPDGFEDIIAV 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 635 VALFRPGPLQSGMVDNFIDRKHGREAISYPdiewqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGK 714
Cdd:TIGR00594 632 NALYRPGPMESGMIPDFIDRKHGREPIEYP-----HPLLEPILKETYGVIVYQEQVMQIAQRLAGFSLGEADLLRRAMGK 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 715 KNPVEMAKQRGGFEDGAKSRGVNGELAVKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNT 794
Cdd:TIGR00594 707 KKAEEMAKEREKFVEGAEKNGYDPEIAENLFDLIEKFAGYGFNKSHAAAYGMISYQTAYLKANYPAEFMAALLTSEINDI 786
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 795 DKVVGLVDECWRMGLKILPPDINSGLYHFHVNDDGeIVYGIGAIKGVGEGPIEAIIEARNQGGYFRELFDLCARTDIKKL 874
Cdd:TIGR00594 787 EKVAVYIAEAKKMGIEVLPPDINESGQDFAVEDKG-IRYGLGAIKGVGESVVKSIIEERNKNGPFKSLFDFINRVDFKKL 865
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 875 NRRVLEKLIMSGAFDRLGPHRAALMNSLPDALKAADQHAKAEAIGQVDMFGVLADAPEQVEQSYSTVPPWPEQVVLDGER 954
Cdd:TIGR00594 866 NKKVLEALIKAGAFDSLGPNRKTLLASLDDALDAVSRKKKAEALGQNSLFGALSEGTKPEYVFFPPDEEWPDKKLLALEK 945
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 746426554 955 ETLGLYLTGHPITQYIKEIERYAGGVRLKDMHPTDRGKMTTAVGLVLAARVMVTKRGNRIGVCTLDDRSGRLEIMLF 1031
Cdd:TIGR00594 946 ETLGLYVSGHPLDAYEKALKNTATPAAIEDLEAPNDSQVRTLGGLNSVKKKITTKNGKPMAFLQLEDETGSIEVVVF 1022
|
|
| dnaE |
PRK06826 |
DNA polymerase III DnaE; Reviewed |
3-1155 |
0e+00 |
|
DNA polymerase III DnaE; Reviewed
Pssm-ID: 235868 [Multi-domain] Cd Length: 1151 Bit Score: 1238.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 3 EPRFVHLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADFCV-------ESD 75
Cdd:PRK06826 2 KMSFVHLHVHTEYSLLDGSARIKDLIKRAKELGMDSIAITDHGVMYGVVDFYKAAKKQGIKPIIGCEVYVaprsrfdKEP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 76 ELGDELAHLTVLAMNNAGYQNLTLLISHAYQRGYgAAGPTIDRDWLVEHQEGLILLSGGRRGDVGRFLLRGNQTQAEQCL 155
Cdd:PRK06826 82 DIDNETYHLVLLAKNETGYKNLMKIVSKAFTEGF-YYKPRVDHELLKEHSEGLIALSACLAGEVPRYILKGNYEKAKEAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 156 AFYQEHF-PQRYYLELIRTSRPDEESYLHAAVELATKHGVPVVATNEVCFISTDDFDAHEIRVAIHDGYTLDDPKRPRNY 234
Cdd:PRK06826 161 LFYKDIFgKENFYLELQDHGIPEQRKVNEELIKLSKELGIPLVATNDVHYIRKEDAKAHDVLLCIQTGKTVDDENRMRFP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 235 SPQQYMRSEEEMCELFADIPEALANSVEIAKRCNVTIRLGEYFLPQFPTGD-MSTEDFLVQCSKKGLEERleflFPDPEv 313
Cdd:PRK06826 241 SDEFYLKSPEEMYELFSYVPEALENTVKIAERCNVEFEFGKSKLPKFPLPEgYDPYEYLRELCYEGLKKR----YPNPS- 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 314 raerrPEYDERLDIELGVINQMGFPGYFLIVMEFIQWSKDNDVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLN 393
Cdd:PRK06826 316 -----EELIERLEYELSVIKQMGYVDYFLIVWDFIRFARENGIMVGPGRGSAAGSLVAYTLGITKIDPIKYNLLFERFLN 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 394 PERVSMPDFDVDFCMEKRDKVIDHVAEMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPGMTLEK 473
Cdd:PRK06826 391 PERVSMPDIDIDFCYERRQEVIDYVVEKYGKDRVAQIITFGTMAARAAIRDVGRALNYPYAEVDRIAKMIPTELGITIDK 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 474 AFAAEPQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVISPTKITDFAPLYcDAEGNhPVTQFDKNDVEYAGLVK 553
Cdd:PRK06826 471 ALELNPELKEAYENDERVRELIDTARALEGLPRHASTHAAGVVISSEPLVEYVPLQ-KNDGS-IVTQFTMTTLEELGLLK 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 554 FDFLGLRTLTIIDWALGMINARRAkqglEPIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIA 633
Cdd:PRK06826 549 MDFLGLRTLTVIRDAVDLIKKNRG----IEIDLDKIDYDDKKVYKMIGEGKTVGVFQLESAGMRSFMKELKPDSLEDIIA 624
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 634 LVALFRPGPLQSgmVDNFIDRKHGREAISYpdiewQHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMG 713
Cdd:PRK06826 625 GISLYRPGPMDS--IPRYIKNKNNPEKIEY-----LHPKLEPILKVTYGCIVYQEQVMQIVRDLAGYSMGRSDLVRRAMS 697
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 714 KKNPVEMAKQRGGF--------EDGAKSRGVNGELAVKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAA 785
Cdd:PRK06826 698 KKKHDVMEEERKNFiygivdegGPGCIRNGIDEETANKIFDSMMDFASYAFNKSHAAAYAVVAYQTAYLKRYYPVEFMAA 777
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 786 VMTADMDNTDKVVGLVDECWRMGLKILPPDINSGLYHFHVNDDgEIVYGIGAIKGVGEGPIEAIIEARNQGGYFRELFDL 865
Cdd:PRK06826 778 LLNSVMGNSDKVAFYIEECRRLGIEVLPPDINESYSKFTVEGD-KIRFGLAAVKNVGENAIDSIVEEREKKGKFKSLVDF 856
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 866 CARTDIKKLNRRVLEKLIMSGAFDRLGPHRAALMNSLPDALKAADQHAKAEAIGQVDMFGVLADAPEQVEQ-SYSTVPPW 944
Cdd:PRK06826 857 CERVDTSQINKRAVESLIKAGAFDSLGVYRSQLLAVYEKILDSISKQRKKNIEGQISLFDLIGEEEESSLEiKYPDIKEF 936
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 945 PEQVVLDGERETLGLYLTGHPITQYIKEIERYAgGVRLKDMHPTDRGKMTTAV---------GLVLAARVMVTKRGNRIG 1015
Cdd:PRK06826 937 DKKELLAMEKEMLGLYISGHPLEEYEETLKKQT-SATISDIISDEEEDGESKLkdgdkviigGIITEVKRKTTRNNEMMA 1015
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 1016 VCTLDDRSGRLEIMLFTDALEKYQHLLEKDRILIASGQVSFDDfSGGLKMTVRELMDISEAREKyarGLAISLTDRQIDD 1095
Cdd:PRK06826 1016 FLTLEDLYGTVEVIVFPKVYEKYRSLLNEDNIVLIKGRVSLRE-DEEPKLICEEIEPLVINSEK---KLYLRVEDKKDIK 1091
|
1130 1140 1150 1160 1170 1180
....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 1096 QLLNRLRQSLEPHrSGTIPVHLYYqrEDARARLRFGAAWRVTPADALLNELRTLVGNEQV 1155
Cdd:PRK06826 1092 LKLKELKEILKQY-PGNTPVYLYT--EKERKKFKLDRELWVNLSPELINELKELLGEENV 1148
|
|
| dnaE |
PRK07374 |
DNA polymerase III subunit alpha; Validated |
6-1148 |
0e+00 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 168927 [Multi-domain] Cd Length: 1170 Bit Score: 968.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 6 FVHLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADFCVESDELGDELA--- 82
Cdd:PRK07374 3 FVPLHNHSDYSLLDGASQLPKMVERAKELGMPAIALTDHGVMYGAIELLKLCKGKGIKPIIGNEMYVINGSIDDPQPkke 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 83 ---HLTVLAMNNAGYQNLTLL--ISHAY-QRGYGA-AGPTIDRDWLVEHQEGLILLSGGRRGDVGRFLLRGNQTQAEQCL 155
Cdd:PRK07374 83 kryHLVVLAKNATGYKNLVKLttISHLNgMRGRGIfSRPCIDKELLKQYSEGLIVSTACLGGEIPQAILRGRPDVARDVA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 156 AFYQEHFPQRYYLELIRTSRPDEESYLHAAVELATKHGVPVVATNEVCFISTDDFDAHEIRVAIHDGYTLDDPKRPRnYS 235
Cdd:PRK07374 163 AWYKEVFGDDFYLEIQDHGSIEDRIVNVELVRIAKELGIKLIATNDAHYLSKNDVEAHDALLCVLTGKLISDEKRLR-YT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 236 PQQYMRSEEEMCELFAD------IPEALANSVEIAKRCNVTIRLGEYFLPQFPTGDMST-EDFLVQCSKKGLEERLEFLF 308
Cdd:PRK07374 242 GTEYIKSEEEMLRLFRDhldpevIQEAIANTVEVAEKVEEYDILGTYRMPRFPIPEGHTaVSYLTEVTEQGLLKRLKLNS 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 309 PDpevraERRPEYDERLDIELGVINQMGFPGYFLIVMEFIQWSKDNDVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLF 388
Cdd:PRK07374 322 LD-----EIDENYKERLSYELKIIEQMGFPTYFLVVWDYIRFAREQGIPVGPGRGSAAGSLVAYALGITNIDPVKNGLLF 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 389 ERFLNPERVSMPDFDVDFCMEKRDKVIDHVAEMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPG 468
Cdd:PRK07374 397 ERFLNPERKSMPDIDTDFCIERRGEVIDYVTRRYGEDKVAQIITFNRMTSKAVLKDVARVLDIPYGEADRLAKLIPVVRG 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 469 --MTLEKAFAAE---PQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVISPTKITDFAPLYCDAEGnHPVTQFDK 543
Cdd:PRK07374 477 kpAKLKAMIGKEspsPEFREKYEKDPRVKKWVDMAMRIEGTNKTFGVHAAGVVIASDPLDELVPLQRNNDG-QVITQYFM 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 544 NDVEYAGLVKFDFLGLRTLTIIDWALGMINARRAKQglepIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRL 623
Cdd:PRK07374 556 EDIESLGLLKMDFLGLKNLTMIEKTLELVEQSTGER----IDPDNLPLDDEKTFELLARGDLEGIFQLESSGMRQVVRDL 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 624 KPDCFEDMIALVALFRPGPLQSGMVDNFIDRKHGREAISYPdiewqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLG 703
Cdd:PRK07374 632 KPSSLEDISSILALYRPGPLDAGLIPKFINRKHGREAIDFA-----HPLLEPILTETYGIMVYQEQIMKIAQDLAGYSLG 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 704 GADMLRRAMGKKNPVEMAKQRGGFEDGAKSRGVNGELAVKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFM 783
Cdd:PRK07374 707 QADLLRRAMGKKKVSEMQKHRGIFVEGASKRGVDEKVADELFDQMVLFAEYCFNKSHSTAYGAVTYQTAYLKAHYPVAYM 786
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 784 AAVMTADMDNTDKVVGLVDECWRMGLKILPPDINSGLYHFHVNDDgEIVYGIGAIKGVGEGPIEAIIEARNQGGYFRELF 863
Cdd:PRK07374 787 AALLTVNAGSSDKVQRYISNCNSMGIEVMPPDINRSGIDFTPKGN-RILFGLSAVKNLGDGAIRNIIAARDSDGPFKSLA 865
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 864 DLCARTDIKKLNRRVLEKLIMSGAFDRLGP--HRAALMNSLPDALKAADQHAKAEAIGQVDMFGVLADAPEQVEQSYST- 940
Cdd:PRK07374 866 DLCDRLPSNVLNRRSLESLIHCGALDAFSPnaNRAQLIADLDLVLDWASSRARDRASGQGNLFDLLAGSEEEASNDLSSa 945
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 941 -----VPPWPEQVVLDGERETLGLYLTGHPITQyIKEIERYAGGVRLKDMHPT-DRGKMtTAVGLVLAARVMVTKRGNRI 1014
Cdd:PRK07374 946 pkaapVPDYPPTEKLKLEKELLGFYLSDHPLKQ-LTEPAKLLAPISLSSLEEQpDKAKV-SAIAMIPEMKQVTTRKGDRM 1023
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 1015 GVCTLDDRSGRLEIMLFTDALEKYQHLLEKDRILIASGQVsfDDFSGGLKMTVRELMDISEAREkyargLAISLTDRQID 1094
Cdd:PRK07374 1024 AILQLEDLTGSCEAVVFPKSYERLSDHLMTDTRLLVWAKV--DRRDDRVQLIIDDCREIDDLRL-----LLVELDPDQAS 1096
|
1130 1140 1150 1160 1170 1180
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 746426554 1095 D-QLLNRLRQSLEPHRSGT------IPVHLYYQREDARARLRFGAAWRVTPADALLNELRT 1148
Cdd:PRK07374 1097 DiRVQHKLRECLQKHRPERdelgvkIPVVAAVRNGNSVRYVRLGHQFCVKDAQAAVKALQQ 1157
|
|
| dnaE |
PRK06920 |
DNA polymerase III subunit alpha; |
6-1158 |
0e+00 |
|
DNA polymerase III subunit alpha;
Pssm-ID: 180749 [Multi-domain] Cd Length: 1107 Bit Score: 879.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 6 FVHLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADFCVESDElgDELAH-L 84
Cdd:PRK06920 3 FVHLQCQTVFSLLKSACKIDELVVRAKELGYSSLAITDENVMYGVIPFYKACKKHGIHPIIGLTASIFSEE--EEKSYpL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 85 TVLAMNNAGYQNLtLLISHAYQrgyGAAGPTIDRDWLVEHQEGLILLSGGRRGDVGRFLLRGNQTQAEQCLAFYQEHFPQ 164
Cdd:PRK06920 81 VLLAENEIGYQNL-LKISSSIM---TKSKEGIPKKWLAHYAKGLIAISPGKDGEIEQLLLEDKESQAEEVARAYQNMFGN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 165 rYYLELIRTSRPDEESYLHAAVELATKHGVPVVATNEVCFISTDDFDAHEIRVAIHDGYTLDDPKRPRNYSPQQYMRSEE 244
Cdd:PRK06920 157 -FYMSLQHHAIQDELLLQEKLPEFSNRVNIPVVATNDVRYINQSDALVHECLLSVESGTKMTDPDRPRLKTDQYYLKSSD 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 245 EMCELFADIPEALANSVEIAKRCNVTIRLGEYFLPQFPTGDMST-EDFLVQCSKKGLEERleFLFPDPEvraerrpeYDE 323
Cdd:PRK06920 236 EMEALFSHVPEAIYNTVEIAERCRVEIPFHVNQLPKFPVPSNETaDMYLRRVCEEGLQKR--YGTPKEV--------HIN 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 324 RLDIELGVINQMGFPGYFLIVMEFIQWSKDNDVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSMPDFD 403
Cdd:PRK06920 306 RLNHELNVISRMGFSDYFLIVWDFMKYAHENHILTGPGRGSAAGSLVSYVLEITDIDPIEYDLLFERFLNPERVTLPDID 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 404 VDFCMEKRDKVIDHVAEMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPGMTLEKAFAAEPQLPE 483
Cdd:PRK06920 386 IDFPDTRRDEMIRYVKDKYGQLRVAQIVTFGTLAAKAAIRDIARVMGLPPRDIDIFSKLIPSKLGITLKDAYEESQSLRE 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 484 IYEADEEVKALIDMARKLEGVTRNAGKHAGGVVISPTKITDFAPLycdAEGNHPV--TQFDKNDVEYAGLVKFDFLGLRT 561
Cdd:PRK06920 466 FIQGNLLHERVFEIAKRVEGLPRHTSIHAAGVIMSQEPLTGSVAI---QEGHNDVyvTQYPADALEELGLLKMDFLGLRN 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 562 LTIIDWALGMINARRAKQglepIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVALFRPG 641
Cdd:PRK06920 543 LTLLENIIKFIEQKTGKE----IDIRNLPLQDEKTFQLLGRGDTTGVFQLESSGMRNVLRGLKPNEFEDIVAVNSLYRPG 618
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 642 PLQSgmVDNFIDRKHGREAISYPdiewqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGKKNPVEMA 721
Cdd:PRK06920 619 PMEQ--IPTFIESKHGKRKIEYL-----HPDLKPILERTYGVIVYQEQIMQIASKLAGFSLGEADLLRRAVSKKNRDILD 691
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 722 KQRGGFEDGAKSRGVNGELAVKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTDKVVGLV 801
Cdd:PRK06920 692 QERKHFVQGCLQNGYDETSAEKIYDLIVRFANYGFNRSHAVAYSMIGYQLAYLKANYTLEFMTALLSSAIGNEDKIVQYI 771
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 802 DECWRMGLKILPPDINSGLYHFHVnDDGEIVYGIGAIKGVGEGPIEAIIEARnQGGYFRELFDLCARTDIKKLNRRVLEK 881
Cdd:PRK06920 772 RETKRKGFHVLPPSLQRSGYNFQI-EGNAIRYSLLSIRNIGMATVTALYEER-EKKMFEDLFEFCLRMPSKFVTERNLEA 849
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 882 LIMSGAFDRLGPHRAALMNSLPDALKAADqhakaeaigqvdmfgVLADAPEQVEQS-YSTVPPWPEQVVLDGERETLGLY 960
Cdd:PRK06920 850 FVWSGCFDDFGVSRTNLWKSLKGALEYAN---------------LARDLGDAVPKSkYVQGEELSFIEQLNKEKEVLGFY 914
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 961 LTGHPITQYIKEIERyAGGVRLKDMHPTDRGKMtTAVGLVLAARVMVTKRGNRIGVCTLDDRSGRLEIMLFTDALEKYQH 1040
Cdd:PRK06920 915 LSSYPTAQYVKLAKE-LEIPSLAQAMRHKKKVQ-RAIVYITSVKVIRTKKGQKMAFITFCDQNDEMEAVVFPETYIHFSD 992
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 1041 LLEKDRILIASGQVSFDDFSGGLKMTVRELMDISEA-REKYARGLAISLTDrQIDDQLLNRLRQSLEPHrSGTIPVHLYY 1119
Cdd:PRK06920 993 KLQEGAIVLVDGTIELRNHKLQWIVNGLYPLEEMDAyEEKKDASVYVKLPS-QYEKKLLNQVTKILFDY-SGFAKVLIYY 1070
|
1130 1140 1150
....*....|....*....|....*....|....*....
gi 746426554 1120 QREDARARLrfGAAWRVTPADALLNELRTLVGNEQVELE 1158
Cdd:PRK06920 1071 EKEHKMVQL--SRSLSIHPSEECLGALREIVGEENVVVK 1107
|
|
| PRK09532 |
PRK09532 |
DNA polymerase III subunit alpha; Reviewed |
6-754 |
0e+00 |
|
DNA polymerase III subunit alpha; Reviewed
Pssm-ID: 181933 [Multi-domain] Cd Length: 874 Bit Score: 634.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 6 FVHLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADFCVESDELGDELA--- 82
Cdd:PRK09532 3 FVGLHIHSDYSLLDGASQLPALVDRAIELGMPAIALTDHGVMYGAIELLKVCRNKGIKPIIGNEMYVINGDIEKQKRrrk 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 83 -HLTVLAMNNAGYQNLTLLISHAYQRGYGAAG----PTIDRDWLVEHQEGLILLSGGRRGDVGRFLLRGNQTQAEQCLAF 157
Cdd:PRK09532 83 yHQVVLAKNTQGYKNLVKLTTISHLQGVQGKGifarPCINKELLEQYHEGLIVTSACLGGEIPQAILSGRPDAARKVAKW 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 158 YQEHFPQRYYLELIRTSRPDEESYLHAAVELATKHGVPVVATNEVCFISTDDFDAHEIRVAIHDGYTLDDPKRPRnYSPQ 237
Cdd:PRK09532 163 YKKLFGDDFYLEIQDHGSQEDRIVNVEIVKIARELGIKIIATNDSHFISCYDVEAHDALLCIQTGKLITEDKRLR-YSGT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 238 QYMRSEEEMCELFAD------IPEALANSVEIAKRCNVTIRLGEYFLPQFPTGDMSTED-FLVQCSKKGLEERLEFlfpd 310
Cdd:PRK09532 242 EYLKSAEEMRLLFRDhlpddvIAEAIANTLEVADKIEPYNILGEPRIPNYPVPSGHTPDtYVEEVAWQGLLERLNC---- 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 311 pEVRAERRPEYDERLDIELGVINQMGFPGYFLIVMEFIQWSKDNDVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFER 390
Cdd:PRK09532 318 -KSRSEVEPVYKERLEYELKMLQQMGFSTYFLVVWDYIKYARDNNIPVGPGRGSAAGSLVAYCLKITNIDPVHHGLLFER 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 391 FLNPERVSMPDFDVDFCMEKRDKVIDHVAEMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVP-----P 465
Cdd:PRK09532 397 FLNPERKSMPDIDTDFCIERRDEMIKYVTEKYGEDRVAQIITFNRMTSKAVLKDVARVLDIPYGEADKMAKLIPvsrgkP 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 466 DPGMTLEKAFAAEPQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVISPTKITDFAPLYCDAEGNhPVTQFDKND 545
Cdd:PRK09532 477 TKLKVMISDETPEPEFKEKYDNDPRVRRWLDMAIRIEGTNKTFGVHAAGVVISSEPLDEIVPLQKNNDGA-VITQYFMED 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 546 VEYAGLVKFDFLGLRTLTIIDWALGMI---------------NARRAKQGLEPIDIAAIPLDDKKSFDMLQRSETTAVFQ 610
Cdd:PRK09532 556 LESLGLLKMDFLGLRNLTTIQKTADLIkenrgveidldqlplDERKALKILAKGEAKKLPKDVQKTHKLLERGDLEGIFQ 635
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 611 LESRGMKDLIKRLKPDCFEDMIALVALFRPGPLQSGMVDNFIDRKHGREAISYpdiewQHESLKPVLEPTYGIILYQEQV 690
Cdd:PRK09532 636 LESSGMKQIVRDLKPSNIEDISSILALYRPGPLDAGLIPKFINRKHGREPIDY-----EHQLLEPILNETYGVLVYQEQI 710
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 746426554 691 MQIAQVLAGYTLGGADMLRRAMGKKNPVEMAKQRGGFEDGAKSRGVNGELAVKIFDLVEKFAGY 754
Cdd:PRK09532 711 MKMAQDLAGYSLGEADLLRRAMGKKKISEMQKHREKFIDGAAKNGVSKKVAENLFDQMVKFAEY 774
|
|
| dnaE2 |
PRK05672 |
error-prone DNA polymerase; Validated |
4-1054 |
0e+00 |
|
error-prone DNA polymerase; Validated
Pssm-ID: 235553 [Multi-domain] Cd Length: 1046 Bit Score: 616.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 4 PRFVHLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADFCVeSDELGDELAH 83
Cdd:PRK05672 3 PPYAELHCHSNFSFLDGASHPEELVERAARLGLRALAITDECGLAGVVRAAEAAKELGLRLVIGAELSL-GPDPDPGGPH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 84 LTVLAMNNAGYQNLTLLISHAYQRGyGAAGPTIDRDWLVEHQEGLIL-LSGGRRGDVGRFLLRGNQTQAEQCLA-FYQEH 161
Cdd:PRK05672 82 LLVLARDREGYGRLSRLITRARLRA-GKGEYRLDLDDLAEPAGGHWAiLTGCRKGFVILALPYGGDAAALAALAaLLDAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 162 FPQRYYLELIRTSRPDEESYLHAAVELATKHGVPVVATNEVCFISTDDFDAHEIRVAIHDGYTLDDPKRPRNYSPQQYMR 241
Cdd:PRK05672 161 FADRVWLELTLHGRPDDDRRNARLAALAARAGVPLVATGDVHMHHRSRRRLQDAMTAIRARRSLAEAGGWLAPNGERHLR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 242 SEEEMCELFADIPEALANSVEIAKRCNVTIRLGEYFLPQFPTGDMSTED-FLVQCSKKGLEERleflFPDPevraeRRPE 320
Cdd:PRK05672 241 SGAEMARLFPDYPEALAETVELAERCAFDLDLLAYEYPDEPVPAGHTPAsWLRQLTEAGAARR----YGPG-----IPPK 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 321 YDERLDIELGVINQMGFPGYFLIVMEFIQWSKDNDVpVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSMP 400
Cdd:PRK05672 312 ARAQIEHELALIAELGYEGYFLTVHDIVRFARSQGI-LCQGRGSAANSAVCYALGITEVDPVQSGLLFERFLSPERDEPP 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 401 DFDVDFCMEKRDKVIDHVAEMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLV------PPDPGMTLEKA 474
Cdd:PRK05672 391 DIDVDFEHDRREEVIQYVYRRYGRDRAAQVANVITYRPRSAVRDVAKALGLSPGQVDAWAKQVsrwsgsADDLQRLRQAG 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 475 FAAEPQLPEiyeadeevkALIDMARKLEGVTRNAGKHAGGVVISPTKITDFAPLYCDAEGNHPVTQFDKNDVEYAGLVKF 554
Cdd:PRK05672 471 LDPESPIPR---------RVVELAAQLIGFPRHLSQHSGGFVICDRPLARLVPVENAAMEGRSVIQWDKDDCAAVGLVKV 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 555 DFLGLRTLTIIDWALGMINARRAKqglePIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIAL 634
Cdd:PRK05672 542 DVLALGMLSALHRAFDLIAEHRGR----RLTLASIPLDDPAVYDMLCRADSVGVFQVESRAQMAMLPRLRPRTFYDLVVE 617
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 635 VALFRPGPLQSGMVDNFIDRKHGREAISYPdiewqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMG- 713
Cdd:PRK05672 618 VAIVRPGPIQGGMVHPYLRRRNGQEPVTYP-----HPELEKVLERTLGVPLFQEQVMQIAIDAAGFTPGEADQLRRAMAa 692
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 714 KKNPVEMAKQRGGFEDGAKSRGVNGELAVKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTAD-Md 792
Cdd:PRK05672 693 WRRKGRLERLRERLYDGMLARGYTGEFADRIFEQIKGFGEYGFPESHAASFAKLVYASSWLKCHHPAAFCAALLNSQpM- 771
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 793 ntdkvvG------LVDECWRMGLKILPPDINSGLYH----FHVNDDGEIVYGIGAIKGVGEGPIEAIIEARNQGGyFREL 862
Cdd:PRK05672 772 ------GfyspqqLVQDARRHGVEVLPVDVNASGWDatlePLPDGGPAVRLGLRLVRGLGEEAAERIVAARARGP-FTSV 844
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 863 FDLCARTDikkLNRRVLEKLIMSGAFDRLGPHR-AALMNslpdALKAADQHAkaeaigqvdmfGVLADAPEQVEQSYSTV 941
Cdd:PRK05672 845 EDLARRAG---LDRRQLEALADAGALRSLGGDRrQALWA----AGAAATERL-----------DLLPGAPASEAAPALPG 906
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 942 PPWPEQVVLDgeRETLGLYLTGHPiTQYIKE---IERYAGGVRLKDMHPTDRgkmttavglVLAARVmVTKR---GNRIG 1015
Cdd:PRK05672 907 MSEGELVAAD--YWTTGLSLDSHP-LALLRPrldARGVVSAAELLDVEDGRR---------VRVAGV-VTHRqrpGTASG 973
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|.
gi 746426554 1016 VC--TLDDRSGRLEIMLFTDALEKYQHLLEKDRILIASGQV 1054
Cdd:PRK05672 974 VTflTLEDETGMVNVVVWPGLWERQRREALGARLLLVRGRV 1014
|
|
| dnaE |
PRK07135 |
DNA polymerase III DnaE; Validated |
5-1047 |
0e+00 |
|
DNA polymerase III DnaE; Validated
Pssm-ID: 235944 [Multi-domain] Cd Length: 973 Bit Score: 583.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 5 RFVHLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADFCVESdelgdelAHL 84
Cdd:PRK07135 2 KLINLHTNTEYSFLSSTIKLDSLIKYAKENNLKTLVLTDHNNMFGVPKFYKLCKKNNIKPIIGLDLEVEN-------FRF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 85 TVLAMNNAGYQNLTLLISHAyqrgygAAGPTIDRDWLVEhqEGLILLSGGRRGdvgrflLRGNQTQAEQCLAFY----QE 160
Cdd:PRK07135 75 ILLAKNYSGYKLLNELSSKK------SKNKEIELNDLDS--DNIIIIDHPKNG------FYAKNKEQLELKNYYinsnDP 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 161 HFPQRYYLELIRTSRPDEESYLHAAVELATkhgvpvvatNEVCFISTDDFDAHEIrvaihdgytlddpkrprnyspqqym 240
Cdd:PRK07135 141 KIENAVYVQERKLLFAEDNEYLKILNKIGN---------NKEENSNFKFFDFEKW------------------------- 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 241 rseeemcelFADIPEA-LANSVEIAKRCNVTIRLGEYFLPQFPTG-DMSTEDFLVQCSKKGLEERLEFLFPDPEVRaerr 318
Cdd:PRK07135 187 ---------FEDIDEKiLKRTNYLVENINIEFPKKEFNLPDFDNNlGLESDLFLKKILKESVINKKAELKYYPNVK---- 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 319 peydERLDIELGVINQMGFPGYFLIVMEFIQWSKDNDVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVS 398
Cdd:PRK07135 254 ----ERINYEYSVIKKLKFSNYFLIIWDFIKWARKNKISIGPGRGSASGSLVSYLLNITSVNPLKYDLLFERFLNPDRIT 329
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 399 MPDFDVDFCMEKRDKVIDHVAEMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPpdPGMTLEKAFAAE 478
Cdd:PRK07135 330 MPDIDIDIQDDRRDEVIDYIFEKYGYEHCATISTFQTLGAKSAIRDVGRMLGIPESDVNAISKLIP--NNQSLEEAYDKN 407
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 479 PQL-PEIYEADEEV-KALIDMARKLEGVTRNAGKHAGGVVISPTKITDFAPLYCDAEGNHPVtQFDKNDVEYAGLVKFDF 556
Cdd:PRK07135 408 KSFfRELISKGDPIyKKLYKIAKKLEGLPRQSGTHAAGIIISNKPITNYVPTFESKDNYNQV-QYSMEFLEDFGLLKIDL 486
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 557 LGLRTLTIIDWALGMINarRAKQGLEPIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVA 636
Cdd:PRK07135 487 LGLKNLTIIKNIEEKIN--KELLFDHLINFNDLPIIDKKTNNLLSNGKTEGIFQLESPGMKSTIKKVGIDSFEDIVAIIS 564
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 637 LFRPGPLQsgMVDNFIDRKHGREaisypDIEWQHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGKKN 716
Cdd:PRK07135 565 LYRPGPIQ--YIPIYAKNKKNPK-----NIEKIHPEYDEIVAPTYGIIIYQEQIMQIAQKVAGFSFAQADLLRRAISKKD 637
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 717 PVEMAKQRGGFEDGAKSRGVNGELAVKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTDK 796
Cdd:PRK07135 638 ETKLDKIKDKFIEGGIKNGYSKKVLEKIYSLIEKFADYGFNKSHAVAYATLAYKMAYYKANYPLVFYSALISNSNGSQEN 717
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 797 VVGLVDECWRMGLKILPPDINSGLYHfHVNDDGEIVYGIGAIKGVGEGPIEAIIEARNQGGYFRELFDLCARTDIKKLNR 876
Cdd:PRK07135 718 IKKYVKEAKNNGIKVYSPDINFSTEN-AVFDNGKIFLPLIMIKGLGSVAIKKIIDERNKNGKYKNFFDFILRLKFIGISK 796
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 877 RVLEKLIMSGAFDRLGPhraalMNSLPDALKAADQHA------KAEAIGQVDMFGVLaDAPEQVEQSystvpPWPEQVVL 950
Cdd:PRK07135 797 SIIEKLIKANTLRSFGN-----QDTLLNNLELAKNYAetilskVAKNLYDDYKNFGL-DLEFILEEI-----ERDLEEES 865
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 951 DGERETLGLYLTGHPITQYIKEieryagGVRLKDMHPtdrgKMTTAVGLVLAARVMVTKRGNRIGVCTLDDRSGRLEIML 1030
Cdd:PRK07135 866 KNEIEYLGMSFNAFDTNKLEKN------QIRLKDLRI----NTEYRLAIEVKNVKRLRKANKEYKKVILSDDSVEITIFV 935
|
1050
....*....|....*..
gi 746426554 1031 FTDALEKYQHLLEKDRI 1047
Cdd:PRK07135 936 NDNDYLLFETLKKGDIY 952
|
|
| dnaE |
PRK07279 |
DNA polymerase III DnaE; Reviewed |
6-1122 |
0e+00 |
|
DNA polymerase III DnaE; Reviewed
Pssm-ID: 180917 [Multi-domain] Cd Length: 1034 Bit Score: 564.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 6 FVHLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADFCVESDELGdelAHLT 85
Cdd:PRK07279 2 FAQLDTKTVYSFMDSLIDLEKYVERAKELGYQTIGIMDKDNLYGAYHFIEGAQKNGLQPILGLELNIFVEEQE---VTLR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 86 VLAMNNAGYQNLtLLISHAYQRGygaagptiDRDW--LVEHQEGLILLsggrrgdvgrfllrgnqtqaeqclafyqehFP 163
Cdd:PRK07279 79 LIAKNTQGYKNL-LKISTAKMSG--------KKQFsdLSQYLEGIAVI------------------------------VP 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 164 qryYLELIRTSRPDEESYLhaAVELATKH---GVPVVATNEVCFISTDDFDAHEIRVAIHDGYTLDD-PKRPRNyspqQY 239
Cdd:PRK07279 120 ---YFDWSETLELPFDYYI--GVDQETPGsdfKRPILPLRTVRYFESADRETLQMLHAIRDNLSLREvPLVSSD----QE 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 240 MRSEEEMCELFAD-IPEALANSVEIAKrcNVTIRLGEYF-LPQFpTGDMSTEDFLVQCSKKGLEERLEFLfpdpevraer 317
Cdd:PRK07279 191 LISCQSLETLFQErFPQALDNLEKLVS--GISYDFDTDLkLPRF-NRDRPAVEELRELAELGLKEKGLWS---------- 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 318 rPEYDERLDIELGVINQMGFPGYFLIVMEFIQWSKDNDVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERV 397
Cdd:PRK07279 258 -SPYQERLDKELSVIHDMGFDDYFLIVWDLLRFGRSQGYYMGMGRGSAAGSLVAYALDITGIDPVKHNLLFERFLNKERY 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 398 SMPDFDVDFCMEKRDKVIDHVAEMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHP-YGFVDRISKLVPPDpgmTLEKAFA 476
Cdd:PRK07279 337 SMPDIDIDLPDIYRSEFLRYVRNRYGSDHSAQIVTFSTFGAKQAIRDVFKRFGVPeYELSNLTKKISFRD---SLASVYE 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 477 AEPQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVISPTKITDFAPLycDAEGNHPVTQFDKNDVEYAGLVKFDF 556
Cdd:PRK07279 414 KNISFRQIINSKLEYQKAFEIAKRIEGNPRQTSIHAAGVVMSDDDLTNHIPL--KYGDDMMITQYDAHAVEANGLLKMDF 491
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 557 LGLRTLTIIDwalGMINARRAKQGLEpIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVA 636
Cdd:PRK07279 492 LGLRNLTFVQ---KMQEKVAKDYGIH-IDIEAIDLEDKETLALFAAGDTKGIFQFEQPGAINLLKRIKPVCFEDIVATTS 567
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 637 LFRPGPlqSGMVDNFIDRKHGREAISYPDiewqhESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGKKN 716
Cdd:PRK07279 568 LNRPGA--SDYTDNFVKRRHGQEKVDLID-----PVIAPILEPTYGIMLYQEQVMQIAQVFAGFSLGKADLLRRAMSKKN 640
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 717 PVEMAKQRGGFEDGAKSRGVNGELAVKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMtaDMDNTDK 796
Cdd:PRK07279 641 ASEMQKMEEDFLQGALELGHSEEKARELFDRMEKFAGYGFNRSHAFAYSALAFQLAYFKAHYPAVFYDIML--NYSSSDY 718
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 797 VVGLVDecwrMGLKILPPDINSGLYHFHVnDDGEIVYGIGAIKGVGEGPIEAIIEARNqggyFRELFDLCARTDIKKLNR 876
Cdd:PRK07279 719 ITDALE----FGFEVAKLSINTIPYHDKI-ENKKIYLGLKNIKGLPRDLAYWIIENRP----FSSIEDFLTRLPENYQKK 789
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 877 RVLEKLIMSGAFDRLGPHRAALMNSLPDALKAADqhakaeaigqvDMFGVLADApeqvEQSYSTVPPWPEQVVLDGERET 956
Cdd:PRK07279 790 EFLEPLIKIGLFDSFEKNRQKIINNLDNLFVFVN-----------ELGSLFADS----SYSWVEAEDYSETEKYSLEQEL 854
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 957 LGLYLTGHPITQYIKEIERyaggvrlkDMHP-TDRGKMTTAVGLVL--AARVMVTK-RGNRIGVCTLDDRSGRLEIMLFT 1032
Cdd:PRK07279 855 LGVGVSKHPLQAIAEKSSR--------PFTPiSQLVKNSEATILVQiqSIRVIRTKtKGQQMAFLSVTDTKKKLDVTLFP 926
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 1033 DALEKYQHLLEKDRILIASGQVSFDDfsGGLKMTvrelmdISEAREKYARGLAISLTDRQIDDQLLNRLRQSlephrSGT 1112
Cdd:PRK07279 927 ETYRQYKDELKEGKFYYLKGKIQERD--GRLQMV------LQQIQEASSERFWILLENHEHDQEISEILGAF-----PGS 993
|
1130
....*....|
gi 746426554 1113 IPVHLYYQRE 1122
Cdd:PRK07279 994 IPVIIHYQEE 1003
|
|
| PHP_PolIIIA_DnaE1 |
cd07433 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
5-281 |
3.49e-171 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes.
Pssm-ID: 213988 [Multi-domain] Cd Length: 277 Bit Score: 505.09 E-value: 3.49e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 5 RFVHLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADFCVESDELGDELAHL 84
Cdd:cd07433 1 SFVHLRVHSEYSLLDGAVRIKKLVKLAKEDGMPALAITDLSNLFGAVKFYKAASKAGIKPIIGADLNVANPDDADEPFRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 85 TVLAMNNAGYQNLTLLISHAYQRGYGAAGPTIDRDWLVEHQEGLILLSGGRRGDVGRFLLRGNQTQAEQCLAFYQEHFPQ 164
Cdd:cd07433 81 TLLAQNEQGYKNLTELISRAYLEGQRNGGPHIKLEWLAEYSEGLIALSGGRDGDIGQLLLEGNPDLAEALLQFLKKIFPD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 165 RYYLELIRTSRPDEESYLHAAVELATKHGVPVVATNEVCFISTDDFDAHEIRVAIHDGYTLDDPKRPRNYSPQQYMRSEE 244
Cdd:cd07433 161 RFYLELQRHGRPEEEAYEHALIDLAYELGLPLVATNDVRFLKPEDFEAHEARVCIAEGRTLDDPRRPRRYSPQQYFKSAE 240
|
250 260 270
....*....|....*....|....*....|....*..
gi 746426554 245 EMCELFADIPEALANSVEIAKRCNVTIRLGEYFLPQF 281
Cdd:cd07433 241 EMAELFADLPEAIENTVEIAKRCNVRIELGKPFLPDF 277
|
|
| dnaE |
PRK05898 |
DNA polymerase III subunit alpha; |
6-909 |
3.32e-169 |
|
DNA polymerase III subunit alpha;
Pssm-ID: 135648 [Multi-domain] Cd Length: 971 Bit Score: 525.56 E-value: 3.32e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 6 FVHLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADFCVESDElgdelAHLT 85
Cdd:PRK05898 2 FINLNTHSHYSLLSSTLSIDDIIKFALDNNQPYVCLTDLNNLYGCIEFYDKAKAHNLIPIIGLEIEYQSTN-----ATLV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 86 VLAMNNAGYQNLTLLISHAyqrgygAAGPTIDrdwLVEHQEGLILL--SGGRRGDVGRFLLRGNQtQAEQCLAFyqehfp 163
Cdd:PRK05898 77 LYAKNYNGYLNLIKISSFI------MTNKEFE---IQDYLDDLFIVckKGTFVFKSPNFYQTHNQ-NAPNAIAF------ 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 164 qryylelirtsrpdeesylhaavelatkhgvpvvatNEVCFISTDDFDAHEIRVAIHDGYTLDDPKRPRNYSPQQYMrSE 243
Cdd:PRK05898 141 ------------------------------------NSVFYANKNDKIVFNAMLAIKNDLKIDELKNCQDFDNNHFL-ND 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 244 EEMCELFADIpeALANSVEIAKRCNVTIRLGEYFLPQFPT-GDMSTEDFLVQCSKKGLEERLEflfpdpEVRAERRPEYD 322
Cdd:PRK05898 184 NEAQSLFSPI--QLDNLNKVLNELKVEIHDLPINIIKYDKqNSIISSEILKQLCISGLNKRLN------ANDGQVKKIYV 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 323 ERLDIELGVINQMGFPGYFLIVMEFIQWSKDNDVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSMPDF 402
Cdd:PRK05898 256 KRLKYELDIINEKQFDDYFLIVYDFINFAKSNGIIIGPGRGSAAGSLIAYLLHITDIDPIKYNLIFERFLNPTRKSMPDI 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 403 DVDFCMEKRDKVIDHVAEMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLVPPDPGMTLEKAFAAEPQLP 482
Cdd:PRK05898 336 DTDIMDERRDEVVEYLFEKYGNDHVAHIITFQRIKAKMAIRDVGRILGIDLKVIDKICKNIKPDYEEDLDLAIKKNTILK 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 483 EIYEADeevKALIDMARKLEGVTRNAGKHAGGVVISPTKITDFAPLYCDAEgNHPVTQFDKNDVEYAGLVKFDFLGLRTL 562
Cdd:PRK05898 416 EMYVLH---KELFDLAKKIINAPRQIGTHAAGVVLSNSLLTNIIPIQLGIN-DRPLSQYSMEYLERFGLIKMDLLGLKNL 491
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 563 TIIDWALGMINARRAKQglepIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVALFRPGP 642
Cdd:PRK05898 492 TIIDNVLKLIKENQNKK----IDLFNINLNDKNVFEDLAKGRTNGIFQLESPGMKKVLKKVKPQNIEDISIVSALFRPGP 567
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 643 LQSgmVDNFIDRKHGREAISYPDiewqhESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGKKNPVEMAK 722
Cdd:PRK05898 568 QQN--IKTFVERRFKREEFSYWN-----EATKKILEPTHGIIVYQEQVINLVKTIANFDIATADNFRRAISKKDEKILIQ 640
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 723 QRGGFEDGAKSRGVNGELAVKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTDKVVGLVD 802
Cdd:PRK05898 641 LKKDFIEGALKNNYKQPLVNQIFEYIFSFADYGFNHSHSLAYSYISYWMAYLKHYYPLEFLSILLSHTSASKDKLLSYLN 720
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 803 ECWRMGLKILPPDINSGLYHFHV-NDDGEIVYGIGAIKGVGEGPIEAIIEARNQggyfRELFDLCARTDIKKLNR---RV 878
Cdd:PRK05898 721 EAKEFNISIKKPDINYSSNSFVLdTQKQIIRFGFNTIKGFGDELLKKIKSALQN----KTFSDFISYIDALKKNNvslSN 796
|
890 900 910
....*....|....*....|....*....|.
gi 746426554 879 LEKLIMSGAFDRLGPHRAALMNSLPDALKAA 909
Cdd:PRK05898 797 IEILINVGTFDSFKLSRLFLLNNLPEIFEKT 827
|
|
| DNA_pol3_alpha |
pfam07733 |
Bacterial DNA polymerase III alpha NTPase domain; |
290-558 |
1.22e-139 |
|
Bacterial DNA polymerase III alpha NTPase domain;
Pssm-ID: 400196 [Multi-domain] Cd Length: 259 Bit Score: 422.30 E-value: 1.22e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 290 DFLVQCSKKGLEERLeflfpdpevRAERRPEYDERLDIELGVINQMGFPGYFLIVMEFIQWSKDNDVPVGPGRGSGAGSL 369
Cdd:pfam07733 1 EYLRKLVEEGLKERY---------GEGLPEEYQERLEYELNVIIKMGFAGYFLIVWDLVKWAKDNGILVGPGRGSAAGSL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 370 VAYALKITDLDPLEFDLLFERFLNPERVSMPDFDVDFCMEKRDKVIDHVAEMYGRDAVSQIITFGTMAAKAVIRDVGRVL 449
Cdd:pfam07733 72 VAYLLGITEVDPLKHDLLFERFLNPERVSMPDIDIDFEDERREEVIDYVKEKYGRDRVAQIATFGTYAAKSAIRDVGRAL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 450 GHPYGFVDRISKLVPPDPGMtLEKAFAAEPQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVISPTKITDFAPLY 529
Cdd:pfam07733 152 GLPYDEIDRLAKLIPFELGI-LEKALEEEPELKELIESDPEVKRLIELAKKLEGLPRHTGQHAGGVVISPDPLTDFVPLY 230
|
250 260
....*....|....*....|....*....
gi 746426554 530 CDAEGNHPVTQFDKNDVEYAGLVKFDFLG 558
Cdd:pfam07733 231 KADDDDRPVTQFDKDDLEDLGLLKMDFLG 259
|
|
| PHP_PolIIIA_DnaE3 |
cd12113 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
6-279 |
9.31e-92 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, the PolIIIA PHP exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such an activity has not been found. It has been shown that the PHP of PolIIIA has a trinuclear metal complex and is capable of proofreading activity. Bacterial genome replication and DNA repair mechanisms is related to the GC content of its genomes. There is a correlation between GC content variations and the dimeric combinations of PolIIIA subunits. Eubacteria can be grouped into different GC variable groups: the full-spectrum or dnaE1 group, the high-GC or dnaE2-dnaE1 group, and the low GC or polC-dnaE3 group.
Pssm-ID: 213997 [Multi-domain] Cd Length: 283 Bit Score: 295.89 E-value: 9.31e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 6 FVHLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADFCV--------ESDEL 77
Cdd:cd12113 2 FVHLHVHTEYSLLDGAIRIKDLVKRAKELGMPALAITDHGNMFGAIEFYKAAKKAGIKPIIGCEVYVapgsrfdkKDKKG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 78 GDELAHLTVLAMNNAGYQNLTLLISHAYQRG-YGAagPTIDRDWLVEHQEGLILLSGGRRGDVGRFLLRGNQTQAEQCLA 156
Cdd:cd12113 82 DKRYYHLVLLAKNEEGYRNLMKLVSLAYLEGfYYK--PRIDKELLAKYSEGLIALSACLAGEIPQLLLNGDEEEAREAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 157 FYQEHF-PQRYYLELIRTSRPDEESYLHAAVELATKHGVPVVATNEVCFISTDDFDAHEIRVAIHDGYTLDDPKRPRNYS 235
Cdd:cd12113 160 EYRDIFgKDNFYLELQDHGLPEQKKVNEGLIELAKELGIPLVATNDVHYLNKEDAEAHDVLLCIQTGKTLDDPNRMRFDT 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 746426554 236 PQQYMRSEEEMCELFADIPEALANSVEIAKRCNVTIRLGEYFLP 279
Cdd:cd12113 240 DEFYLKSPEEMRELFPDVPEALENTLEIAERCNVELDFGKLHLP 283
|
|
| DNA_pol3_finger |
pfam17657 |
Bacterial DNA polymerase III alpha subunit finger domain; |
561-735 |
2.78e-84 |
|
Bacterial DNA polymerase III alpha subunit finger domain;
Pssm-ID: 407553 [Multi-domain] Cd Length: 166 Bit Score: 270.56 E-value: 2.78e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 561 TLTIIDWALGMINARRAKqglePIDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLKPDCFEDMIALVALFRP 640
Cdd:pfam17657 1 TLTIIRDALDLIKENRGI----GIDLATIPLDDPKTYKLLSSGDTLGVFQFESRGMRQMLKRLKPDTFEDLVALSALYRP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 641 GPLQSGMVDNFIDRKHGREAISYPdiewqHESLKPVLEPTYGIILYQEQVMQIAQVLAGYTLGGADMLRRAMGKKNPVEM 720
Cdd:pfam17657 77 GPMQGGNVDDYIKRKHGKEKIEYP-----HPDLEPILKETYGVIVYQEQVMQIAQILAGFSLGEADLLRRAMGKKKPEEM 151
|
170
....*....|....*
gi 746426554 721 AKQRGGFEDGAKSRG 735
Cdd:pfam17657 152 EKLREKFIEGAKENG 166
|
|
| PRK07373 |
PRK07373 |
DNA polymerase III subunit alpha; Reviewed |
756-1147 |
4.12e-80 |
|
DNA polymerase III subunit alpha; Reviewed
Pssm-ID: 236003 [Multi-domain] Cd Length: 449 Bit Score: 270.01 E-value: 4.12e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 756 FNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTDKVVGLVDECWRMGLKILPPDINSGLYHFHVNDDGeIVYGI 835
Cdd:PRK07373 38 FNKSHSTAYAYVTYQTAYLKANYPVEYMAALLTANSGNQDKVQKYRENCQKMGIEVEPPDINRSGKDFTPVGEK-ILFGL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 836 GAIKGVGEGPIEAIIEARNQGGYFRELFDLCARTDIKKLNRRVLEKLIMSGAFDRLGPHRAALMNSLPDALKAADQHAKA 915
Cdd:PRK07373 117 SAVRNLGEGAIESILKAREEGGEFKSLADFCDRVDLRVVNRRALETLIYCGAFDKIEPNRQQLINDLELVIDWAQKRAKE 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 916 EAIGQVDMFGVL---ADAPEQVEQSYSTVPP------WPEQVVLDGERETLGLYLTGHPITQyIKEIERYAGGVRLKDMH 986
Cdd:PRK07373 197 KASGQGNLFDLLggnTSNSSAANNAFEQAPSappvadFSLQEKLKLEKELLGFYVSEHPLKS-IRRPARLLSPINLSELE 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 987 PTDRGKMTTAVGLVLAARVMVTKRGNRIGVCTLDDRSGRLEIMLFTDALEKYQHLLEKDRILIASGQVSFDDfsGGLKMT 1066
Cdd:PRK07373 276 EQKEKTKVSAVVMLNEVKKIVTKKGDPMAFLQLEDLSGQSEAVVFPKSYERISELLQVDARLIIWGKVDRRD--DQVQLI 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 1067 VRELMDISEAREkyargLAISLTDRQIDD-QLLNRLRQSLEPH----RSGTIPVHLYYQREDARARLRFGAAWRVTPADA 1141
Cdd:PRK07373 354 VEDAEPIEEVRM-----VMVELSPQQAGNiVSQHRLKEILQEQagdkNKAKVPVIAIIQSGGNRQLVRLGQQYWVQDEHS 428
|
....*.
gi 746426554 1142 LLNELR 1147
Cdd:PRK07373 429 AVQALQ 434
|
|
| PHP |
pfam02811 |
PHP domain; The PHP (Polymerase and Histidinol Phosphatase) domain is a putative ... |
8-173 |
4.80e-52 |
|
PHP domain; The PHP (Polymerase and Histidinol Phosphatase) domain is a putative phosphoesterase domain.
Pssm-ID: 460705 [Multi-domain] Cd Length: 171 Bit Score: 180.43 E-value: 4.80e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 8 HLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADFCV------ESDELGDEL 81
Cdd:pfam02811 1 HLHVHSEYSLLDGAARIEELVKRAKELGMPAIAITDHGNLFGAVEFYKAAKKAGIKPIIGCEVYVapgsreETEKLLAKY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 82 AHLTVLAMNNAGYQNLTLLISHAYQRGYgaaGPTIDRDWLVEHQEGLILLSGGRRGDVGRFLLR-GNQTQAEQCLAFYQE 160
Cdd:pfam02811 81 FDLVLLAVHEVGYKNLIKLSSRAYLEGF---KPRIDKELLEEYFEGLIALSGCVLGHLDLILLApGDYEEAEELAEEYLE 157
|
170
....*....|....
gi 746426554 161 HFPQ-RYYLELIRT 173
Cdd:pfam02811 158 IFGEdGFYLEINTH 171
|
|
| PHP_PolIIIA |
cd07431 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; ... |
7-271 |
4.92e-42 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such activity has not been found. It has been shown that the PHP domain of PolIIIA has a trinuclear metal complex and is capable of proofreading activity.
Pssm-ID: 213986 [Multi-domain] Cd Length: 179 Bit Score: 151.97 E-value: 4.92e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 7 VHLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADFCVESDelgDELAHLTV 86
Cdd:cd07431 1 AHLHVHSSYSLLDSAIRPEDLVARAKELGYSALALTDRNVLYGAVRFYKACKKAGIKPIIGLELTVEGD---GEPYPLLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 87 LAMNNAGYQNLTLLISHAYQRGYGAAGPTIDRDWLVEHQEGLILLSGGrrgdvgrfllrgnqtqaeqclafyqehfpqry 166
Cdd:cd07431 78 LAKNNEGYQNLLRLSTAAMLGEEKDGVPYLDLEELAEAASGLLVVLLG-------------------------------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 167 ylelirtsrpdeesylHAAVELATKHGVPVVATNEVCFISTDDFDAHEIRVAihdgytlddpkrprnyspqqymrseeem 246
Cdd:cd07431 126 ----------------PLLLLLAAEQGLPLVATNDVHYLNPEDAFAADVLTA---------------------------- 161
|
250 260
....*....|....*....|....*
gi 746426554 247 celfadiPEALANSVEIAKRCNVTI 271
Cdd:cd07431 162 -------FLAVANTVRIAKECAVEL 179
|
|
| PHP_PolIIIA_DnaE2 |
cd07434 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at ... |
6-268 |
1.07e-34 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; PolIIIA DnaE2 plays a role in SOS mutagenesis/translesion synthesis and has dominant effects in determining GC variability in the bacterial genome. PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. PolC PHP is located in a different location compared to dnaE1, 2, and 3. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. PHP domains found in DnaEs of thermophilic origin exhibit 3'-5' exonuclease activity.
Pssm-ID: 213989 [Multi-domain] Cd Length: 260 Bit Score: 133.74 E-value: 1.07e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 6 FVHLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKfyggAHGA----GIKPIIGADFCVEsdelgdEL 81
Cdd:cd07434 1 YAELHCLSNFSFLRGASHPEELVARAAELGYRALAITDECSLAGVVR----AHAAakelGLKLIVGSELVLA------DG 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 82 AHLTVLAMNNAGYQNLTLLISHAYQRG----YgaagpTIDRDWLVEHQEGLILLsggrrgDVGRFLLRGNQTQAEQcLAF 157
Cdd:cd07434 71 TRLVLLARDRAGYGRLCRLITLGRRRAekgeY-----RLTLADLLAHAEGLLLI------LLPPDRLPAAAALLAQ-LRW 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 158 YQEHFPQRYYLELIRTSRPDEESYLHAAVELATKHGVPVVATNEVCFISTDDFDAHEIRVAIHDGYTLDD--PKRPRNys 235
Cdd:cd07434 139 LARAFPGRLWLALELHLGGDDARRLARLAALAAALGLPLVATGDVLMHSPSRRPLQDVLTAIRLGTTVAEagRRLAAN-- 216
|
250 260 270
....*....|....*....|....*....|...
gi 746426554 236 PQQYMRSEEEMCELFADIPEALANSVEIAKRCN 268
Cdd:cd07434 217 AERHLRSPAELARLFLYPPEALAETLEIAARCT 249
|
|
| PHP_PolIIIA_POLC |
cd07435 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at ... |
7-264 |
1.89e-31 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; DNA polymerase III alphas (PolIIIAs) that contain a PHP domain have been classified into four basic groups based on phylogenetic and domain structural analyses: polC, dnaE1, dnaE2, and dnaE3. The PolC group is distinct from the other three and is clustered together. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. PolC PHP is located in different location compare to dnaE1, 2, and 3. The PHP domain has four conserved sequence motifs and and contains an invariant histidine that is involved in metal ion coordination.The PHP domain of PolC is structurally homologous to other members of the PHP family that have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel. PHP domains found in dnaEs of thermophilic origin exhibit 3'-5' exonuclease activity. In contrast, PolC PHP lacks detectable nuclease activity.
Pssm-ID: 213990 [Multi-domain] Cd Length: 268 Bit Score: 124.51 E-value: 1.89e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 7 VHLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIG--ADFcVESDelgdelaHL 84
Cdd:cd07435 2 VELHAHTKMSAMDGVTSVKELVKRAAEWGHKAIAITDHGVVQAFPEAYEAAKKNGIKVIYGveAYL-VDPY-------HI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 85 TVLAMNNAGYQNLTLLISHAYQRgYGAAGPTIDRDWLVEHQEGLILLSGGRRGDVGRFLLRGN-QTQAEQCLAFYQ--EH 161
Cdd:cd07435 74 TILVKNQTGLKNLYKLVSLSHTK-YFYRVPRIPKSELEKYREGLLIGSACENGELFEAALNKKsDEELEEIASFYDyiEI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 162 FPQRYYLELIRTSRPDEESYLHAA----VELATKHGVPVVATNEVCFISTDDfdaHEIRVAIHDGYTLDDPKrpRNYSPQ 237
Cdd:cd07435 153 QPLDNYQFLIEKGLIKSEEELKEInkriIKLGKKLNKPVVATGDVHYLDPED---KIYREILLAGQGGGDGR--ADEQPD 227
|
250 260 270
....*....|....*....|....*....|...
gi 746426554 238 QYMRSEEEMCELFADIPEALA------NSVEIA 264
Cdd:cd07435 228 LYFRTTDEMLDEFSYLGEEKAyevvvtNTNKIA 260
|
|
| HHH_6 |
pfam14579 |
Helix-hairpin-helix motif; The HHH domain is a short DNA-binding domain. |
808-898 |
6.87e-31 |
|
Helix-hairpin-helix motif; The HHH domain is a short DNA-binding domain.
Pssm-ID: 434050 [Multi-domain] Cd Length: 88 Bit Score: 116.42 E-value: 6.87e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 808 GLKILPPDINSGLYHFHVNDdGEIVYGIGAIKGVGEGPIEAIIEARNQGGyFRELFDLCARTDiKKLNRRVLEKLIMSGA 887
Cdd:pfam14579 1 GIEVLPPDINRSDWDFTVEG-GGIRLGLGAIKGLGEAAAERIVEERENGP-FKSLEDFARRVD-LKLNKRVLEALIKAGA 77
|
90
....*....|.
gi 746426554 888 FDRLGPHRAAL 898
Cdd:pfam14579 78 FDSLGGNRRQL 88
|
|
| polC |
PRK00448 |
DNA polymerase III PolC; Validated |
83-891 |
2.75e-27 |
|
DNA polymerase III PolC; Validated
Pssm-ID: 234767 [Multi-domain] Cd Length: 1437 Bit Score: 120.71 E-value: 2.75e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 83 HLTVLAMNNAGYQNLTLLISHAYQRgYGAAGPTIDRDWLVEHQEGLILLSGGRRGDVGRFLLRGNQTQAEQCLAFYQ--E 160
Cdd:PRK00448 612 HATILVKNQVGLKNLFKLVSLSNTK-YFYRVPRIPRSLLDKYREGLLIGSACEEGEVFDAVLQKGDEELEEIAKFYDyiE 690
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 161 HFPQRYYLELIRTSRPDEESYLHAA----VELATKHGVPVVATNEVCFISTDDFDAHEIRVAihdGYTLDDPKRpRNYSP 236
Cdd:PRK00448 691 IQPPANYQHLIERELVKDEEELKEIiknlIELGKKLNKPVVATGDVHYLDPEDKIYRKILVA---SQGGGNPLN-RHPLP 766
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 237 QQYMRSEEEMCELFADIPEALA------NSVEIAKRC-NVTIRLGEYFLPQFPTGDMSTEDFLVQCSKKGLEERLeflfp 309
Cdd:PRK00448 767 ELHFRTTDEMLDEFAFLGEELAkeivveNTNKIADLIeEIEPIKDKLYTPKIEGAEEEIRELTYKKAHEIYGEPL----- 841
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 310 dPEVraerrpeYDERLDIELGVINQMGFPGYFLIVMEFIQWSKDNDVPVGPgRGSGAGSLVAYALKITDLDPLE------ 383
Cdd:PRK00448 842 -PEI-------VEKRIEKELNSIIGNGFAVIYLISQKLVKKSLEDGYLVGS-RGSVGSSFVATMIGITEVNPLPphyvcp 912
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 384 ----------------FDLL-------------------FERFLNPERVSMPDFDVDFCMEKRDKVIDHVAEMYGRDAVS 428
Cdd:PRK00448 913 nckysefftdgsvgsgFDLPdkdcpkcgtklkkdghdipFETFLGFKGDKVPDIDLNFSGEYQPVAHNYTKVLFGEDHVF 992
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 429 QIITFGTMAAKAVirdvgrvlghpYGFVdrisKLVPPDPGMTLEKAFaaepqlpeiyeadeevkalID-MARKLEGVTRN 507
Cdd:PRK00448 993 RAGTIGTVAEKTA-----------YGYV----KKYEEDTGKFYRNAE-------------------IDrLAQGCTGVKRT 1038
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 508 AGKHAGGVVISPT--KITDFAPLycdaegNHP---------VTQFDKNDVeYAGLVKFDFLGLRTLTIIdwalgminarR 576
Cdd:PRK00448 1039 TGQHPGGIIVVPKymDIYDFTPI------QYPaddvnsewkTTHFDFHSI-HDNLLKLDILGHDDPTMI----------R 1101
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 577 AKQGLEPIDIAAIPLDDKKsfdmlqrseTTAVF-----------QLES---------------RGMkdlIKRLKPDCFED 630
Cdd:PRK00448 1102 MLQDLTGIDPKTIPMDDPK---------VMKLFsstealgvtpeQIGCetgtlgipefgtkfvRQM---LEETKPKTFAE 1169
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 631 MIALvalfrpgplqSGM-------VDN---FIDRKHG--REAISYPD------IEWQheslkpvLEPTY----------- 681
Cdd:PRK00448 1170 LVQI----------SGLshgtdvwLGNaqeLIKEGIAtlSDVIGCRDdimvylIHKG-------LEPKLafkimesvrkg 1232
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 682 -GIILYQEQVMqiaqvlagytlggadmlrramgKKNPVEmakqrGGFEDGAKsrgvngelavKIfdlvekfaGYGFNKSH 760
Cdd:PRK00448 1233 kGLTEEEEELM----------------------KENNVP-----DWYIESCK----------KI--------KYMFPKAH 1267
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 761 SAAYALVSYQTLWLKAHYPAEFMAA------------VMTA-----------------DMDNTDK----VVGLVDECWRM 807
Cdd:PRK00448 1268 AAAYVLMAWRIAYFKVHYPLAYYAAyfsvraddfdleTMSKgkeaikakmkeikskgnDASNKEKdlltVLEIALEMLER 1347
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 808 GLKILPPDINSGLYHFHVNDDGEIVYGIGAIKGVGEGPIEAIIEARNQGGyFRELFDLCARTdikKLNRRVLEKLIMSGA 887
Cdd:PRK00448 1348 GFKFQKVDLYKSDATEFIIEGDSLIPPFNALPGLGENVAKSIVEAREEGE-FLSKEDLRKRT---KVSKTLIEKLDELGV 1423
|
....
gi 746426554 888 FDRL 891
Cdd:PRK00448 1424 LDDL 1427
|
|
| DnaE_OBF |
cd04485 |
DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding ... |
995-1080 |
2.78e-24 |
|
DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains two copies of this replicative polymerase, each of which copies a different DNA strand. This group also contains Bacillus subtilis DnaE. Replication in B. subtilis and Staphylococcus aureus requires two different type C polymerases, polC and DnaE, both of which are thought to be included in the DNA polymerase holoenzyme. At the B. subtilis replication fork, polC appears to be involved in leading strand synthesis and DnaE in lagging strand synthesis.
Pssm-ID: 239931 [Multi-domain] Cd Length: 84 Bit Score: 97.58 E-value: 2.78e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746426554 995 TAVGLVLAARVMVTKRGNRIGVCTLDDRSGRLEIMLFTDALEKYQHLLEKDRILIASGQVSFDDfsGGLKMTVRELMDIS 1074
Cdd:cd04485 1 TVAGLVTSVRRRRTKKGKRMAFVTLEDLTGSIEVVVFPETYEKYRDLLKEDALLLVEGKVERRD--GGLRLIAERIEDLE 78
|
....*.
gi 746426554 1075 EAREKY 1080
Cdd:cd04485 79 DARERL 84
|
|
| POLIIIAc |
smart00481 |
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family ... |
8-70 |
1.28e-21 |
|
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family of hypothetical proteins
Pssm-ID: 197753 [Multi-domain] Cd Length: 67 Bit Score: 89.25 E-value: 1.28e-21
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 746426554 8 HLRVHSDYSMIDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGADF 70
Cdd:smart00481 1 DLHVHSDYSLLDGALSPEELVKRAKELGLKAIAITDHGNLFGAVEFYKAAKKAGIKPIIGLEA 63
|
|
| PHP |
cd07309 |
Polymerase and Histidinol Phosphatase domain; The PHP (also called histidinol phosphatase-2 ... |
7-70 |
9.25e-16 |
|
Polymerase and Histidinol Phosphatase domain; The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. PHP in polymerases has trinuclear zinc/magnesium dependent proofreading activity. It has also been shown that the PHP domain functions in DNA repair. The PHP structures have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.
Pssm-ID: 213985 [Multi-domain] Cd Length: 88 Bit Score: 73.62 E-value: 9.25e-16
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 746426554 7 VHLRVHSDYSMIDgLAKVGPLVKKAAALGMPALAITDFTNLCGLVKF--------YGGAHGAGIKPIIGADF 70
Cdd:cd07309 1 VDLHTHTVFSDGD-HAKLTELVDKAKELGPDALAITDHGNLRGLAEFntagk*nhIKAAEAAGIKIIIGSEV 71
|
|
| tRNA_anti-codon |
pfam01336 |
OB-fold nucleic acid binding domain; This family contains OB-fold domains that bind to nucleic ... |
1000-1073 |
7.72e-10 |
|
OB-fold nucleic acid binding domain; This family contains OB-fold domains that bind to nucleic acids. The family includes the anti-codon binding domain of lysyl, aspartyl, and asparaginyl -tRNA synthetases (See pfam00152). Aminoacyl-tRNA synthetases catalyze the addition of an amino acid to the appropriate tRNA molecule EC:6.1.1.-. This family also includes part of RecG helicase involved in DNA repair. Replication factor A is a hetero-trimeric complex, that contains a subunit in this family. This domain is also found at the C-terminus of bacterial DNA polymerase III alpha chain.
Pssm-ID: 460164 [Multi-domain] Cd Length: 75 Bit Score: 56.09 E-value: 7.72e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 746426554 1000 VLAARVM-VTKRGNRIGVCTLDDRSGRLEIMLFTDALEKYQHLLEKDRILIASGQVSFDDFsGGLKMTVRELMDI 1073
Cdd:pfam01336 2 TVAGRVTsIRRSGGKLLFLTLRDGTGSIQVVVFKEEAEKLAKKLKEGDVVRVTGKVKKRKG-GELELVVEEIELL 75
|
|
| ComEA |
COG1555 |
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ... |
837-882 |
2.56e-03 |
|
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];
Pssm-ID: 441164 [Multi-domain] Cd Length: 72 Bit Score: 37.53 E-value: 2.56e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 746426554 837 AIKGVGEGPIEAIIEARNQGGYFRELFDLcarTDIKKLNRRVLEKL 882
Cdd:COG1555 25 TLPGIGPKLAQRIVEYREKNGPFKSVEDL---LEVKGIGPKTLEKL 67
|
|
| PHP_HisPPase |
cd07432 |
Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; HisPPase ... |
11-84 |
2.58e-03 |
|
Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; HisPPase catalyzes the eighth step of histidine biosynthesis, in which L-histidinol phosphate undergoes dephosphorylation to produce histidinol. HisPPase can be classified into two types: the bifunctional HisPPase found in proteobacteria that belongs to the DDDD superfamily and the monofunctional Bacillus subtilis type that is a member of the PHP family. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. The PHP domain of HisPPase is structurally homologous to other members of the PHP family that have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.
Pssm-ID: 213987 [Multi-domain] Cd Length: 129 Bit Score: 39.14 E-value: 2.58e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 746426554 11 VHSDYSMiDGLAKVGPLVKKAAALGMPALAITDFTNLCGLVKFYGGAHGAGIKPIIGA--DFCVesdelgdeLAHL 84
Cdd:cd07432 5 IHSVFSP-DSDMTPEEIVERAIELGLDGIAITDHNTIDGAEEALKEAYKDGLLVIPGVevTLVV--------LAHP 71
|
|
| |
