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Conserved domains on  [gi|746637318|ref|WP_039662157|]
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GNAT family N-acetyltransferase [Trueperella pyogenes]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 18514852)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  15581578|9175471|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 96-165 1.01e-14

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 65.83  E-value: 1.01e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 746637318  96 IAVERRYAGHGIGPQLIDGVSEIARAAGAPGISLSVAATNERAHRLYLRMGFEPTGKVVH----GHAVMLRRLA 165
Cdd:COG0456   19 LAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNyygdDALVMEKELA 92
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
7-151 2.54e-12

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


:

Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 61.16  E-value: 2.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746637318   7 DLRLVPTTESDRTYLARL-NFLTDTFGDEFGSLPDDFDEWYNYYIGTWTPVDGGLIAWKGHVPAGGSWLlwgnENYHGFg 85
Cdd:COG1247    1 EMTIRPATPEDAPAIAAIyNEAIAEGTATFETEPPSEEEREAWFAAILAPGRPVLVAEEDGEVVGFASL----GPFRPR- 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 746637318  86 HVSDGVPELAIAVERRYAGHGIGPQLIDGVSEIARAAGAPGISLSVAATNERAHRLYLRMGFEPTG 151
Cdd:COG1247   76 PAYRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVG 141
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 96-165 1.01e-14

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 65.83  E-value: 1.01e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 746637318  96 IAVERRYAGHGIGPQLIDGVSEIARAAGAPGISLSVAATNERAHRLYLRMGFEPTGKVVH----GHAVMLRRLA 165
Cdd:COG0456   19 LAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNyygdDALVMEKELA 92
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
7-151 2.54e-12

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 61.16  E-value: 2.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746637318   7 DLRLVPTTESDRTYLARL-NFLTDTFGDEFGSLPDDFDEWYNYYIGTWTPVDGGLIAWKGHVPAGGSWLlwgnENYHGFg 85
Cdd:COG1247    1 EMTIRPATPEDAPAIAAIyNEAIAEGTATFETEPPSEEEREAWFAAILAPGRPVLVAEEDGEVVGFASL----GPFRPR- 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 746637318  86 HVSDGVPELAIAVERRYAGHGIGPQLIDGVSEIARAAGAPGISLSVAATNERAHRLYLRMGFEPTG 151
Cdd:COG1247   76 PAYRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVG 141
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 42-147 2.48e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 57.53  E-value: 2.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746637318   42 FDEWYNYYIGTWTPVDGGLIAWKGHVPAGGSWLLWGNEN------YHGFGHVSDGVPELAIAVERRYAGHGIGPQLIDGV 115
Cdd:pfam00583   5 YELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGElvgfasLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQAL 84

                          90       100       110
                  ....*....|....*....|....*....|..
gi 746637318  116 SEIARAAGAPGISLSVAATNERAHRLYLRMGF 147
Cdd:pfam00583  85 LEWARERGCERIFLEVAADNLAAIALYEKLGF 116
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 60-149 1.05e-07

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 47.06  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746637318   60 LIAWKGHVPAGGSWLLWGNENYHGFghvsdgvpELAIAVERRYAGHGIGPQLIDgvsEIARAAGAPGISLSVAATNERAH 139
Cdd:pfam13508   6 FVAEDDGKIVGFAALLPLDDEGALA--------ELRLAVHPEYRGQGIGRALLE---AAEAAAKEGGIKLLELETTNRAA 74

                          90
                  ....*....|
gi 746637318  140 RLYLRMGFEP 149
Cdd:pfam13508  75 AFYEKLGFEE 84
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 41-148 4.25e-07

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 46.55  E-value: 4.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746637318   41 DFDEWYNYYIGTwtpVDGGLIAwkGHvpaGGSWLLWGNenyhgfGHVsdgvpeLAIAVERRYAGHGIGPQLIDGVSEIAR 120
Cdd:TIGR01575  25 ELANYHLCYLLA---RIGGKVV--GY---AGVQIVLDE------AHI------LNIAVKPEYQGQGIGRALLRELIDEAK 84

                          90       100
                  ....*....|....*....|....*...
gi 746637318  121 AAGAPGISLSVAATNERAHRLYLRMGFE 148
Cdd:TIGR01575  85 GRGVNEIFLEVRVSNIAAQALYKKLGFN 112
PRK10146 PRK10146
aminoalkylphosphonate N-acetyltransferase;
91-148 5.42e-04

aminoalkylphosphonate N-acetyltransferase;


Pssm-ID: 182266 [Multi-domain]  Cd Length: 144  Bit Score: 38.36  E-value: 5.42e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 746637318  91 VPELAIAVERRyaGHGIGPQLIDGVSEIARAAGAPGISLSVAATNERAHRLYLRMGFE 148
Cdd:PRK10146  79 IQELVVMPQAR--GLNVGSKLLAWAEEEARQAGAEMTELSTNVKRHDAHRFYLREGYE 134
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 60-130 4.09e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 34.17  E-value: 4.09e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 746637318  60 LIAWKGHVPAGgSWLLWGNENYHGFGHVSDgvpelaIAVERRYAGHGIGPQLIDGVSEIARAAGAPGISLS 130
Cdd:cd04301    2 LVAEDDGEIVG-FASLSPDGSGGDTAYIGD------LAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 96-165 1.01e-14

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 65.83  E-value: 1.01e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 746637318  96 IAVERRYAGHGIGPQLIDGVSEIARAAGAPGISLSVAATNERAHRLYLRMGFEPTGKVVH----GHAVMLRRLA 165
Cdd:COG0456   19 LAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNyygdDALVMEKELA 92
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
7-151 2.54e-12

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 61.16  E-value: 2.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746637318   7 DLRLVPTTESDRTYLARL-NFLTDTFGDEFGSLPDDFDEWYNYYIGTWTPVDGGLIAWKGHVPAGGSWLlwgnENYHGFg 85
Cdd:COG1247    1 EMTIRPATPEDAPAIAAIyNEAIAEGTATFETEPPSEEEREAWFAAILAPGRPVLVAEEDGEVVGFASL----GPFRPR- 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 746637318  86 HVSDGVPELAIAVERRYAGHGIGPQLIDGVSEIARAAGAPGISLSVAATNERAHRLYLRMGFEPTG 151
Cdd:COG1247   76 PAYRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVG 141
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
83-155 6.02e-12

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 58.38  E-value: 6.02e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 746637318  83 GFGHVSDGVPEL-AIAVERRYAGHGIGPQLIDGVSEIARAAGAPGISLSVAATNERAHRLYLRMGFEPTGKVVH 155
Cdd:COG3393    7 GVRAESPGVAEIsGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNPAARRLYERLGFRPVGEYAT 80
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 42-147 2.48e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 57.53  E-value: 2.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746637318   42 FDEWYNYYIGTWTPVDGGLIAWKGHVPAGGSWLLWGNEN------YHGFGHVSDGVPELAIAVERRYAGHGIGPQLIDGV 115
Cdd:pfam00583   5 YELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGElvgfasLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQAL 84

                          90       100       110
                  ....*....|....*....|....*....|..
gi 746637318  116 SEIARAAGAPGISLSVAATNERAHRLYLRMGF 147
Cdd:pfam00583  85 LEWARERGCERIFLEVAADNLAAIALYEKLGF 116
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 83-154 9.43e-11

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 56.60  E-value: 9.43e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 746637318  83 GFGHVSDGVPELA-IAVERRYAGHGIGPQLIDGVSEIARAAGAPGISLSVAATNERAHRLYLRMGFEPTGKVV 154
Cdd:COG0454   50 GLRRLDDKVLELKrLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGNPAAIRFYERLGFKEIERYV 122
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 6-151 3.17e-08

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 50.38  E-value: 3.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746637318   6 EDLRLVPTTESDRTYLARL--NFLTDTFGDEFGSLPDDFDEWYNYYIGTWTpvDGGLIAWKGHVPAGGSWLlwGNENYHG 83
Cdd:COG1670    6 ERLRLRPLRPEDAEALAELlnDPEVARYLPGPPYSLEEARAWLERLLADWA--DGGALPFAIEDKEDGELI--GVVGLYD 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 746637318  84 FgHVSDGVPELAIAVERRYAGHGIGPQLIDGVSEIARAA-GAPGISLSVAATNERAHRLYLRMGFEPTG 151
Cdd:COG1670   82 I-DRANRSAEIGYWLAPAYWGKGYATEALRALLDYAFEElGLHRVEAEVDPDNTASIRVLEKLGFRLEG 149
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
88-164 4.21e-08

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 49.31  E-value: 4.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746637318  88 SDGVPELA-IAVERRYAGHGIGPQLIDGVSEIARAAGAPGISLSvaaTNERAHRLYLRMGFEPTGKVVH----GHAVMLR 162
Cdd:COG3153   64 EGPALLLGpLAVDPEYRGQGIGRALMRAALEAARERGARAVVLL---GDPSLLPFYERFGFRPAGELGLtlgpDEVFLAK 140


                 ..
gi 746637318 163 RL 164
Cdd:COG3153  141 EL 142
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 83-152 9.27e-08

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 48.45  E-value: 9.27e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 746637318  83 GFGHV---SDGVPELA-IAVERRYAGHGIGPQLIDGVSEIARAAGAPGISLsvaATNERAHRLYLRMGFEPTGK 152
Cdd:COG1246   41 GCAALhplDEDLAELRsLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFL---LTTSAAIHFYEKLGFEEIDK 111
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 60-149 1.05e-07

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 47.06  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746637318   60 LIAWKGHVPAGGSWLLWGNENYHGFghvsdgvpELAIAVERRYAGHGIGPQLIDgvsEIARAAGAPGISLSVAATNERAH 139
Cdd:pfam13508   6 FVAEDDGKIVGFAALLPLDDEGALA--------ELRLAVHPEYRGQGIGRALLE---AAEAAAKEGGIKLLELETTNRAA 74

                          90
                  ....*....|
gi 746637318  140 RLYLRMGFEP 149
Cdd:pfam13508  75 AFYEKLGFEE 84
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 41-148 4.25e-07

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 46.55  E-value: 4.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746637318   41 DFDEWYNYYIGTwtpVDGGLIAwkGHvpaGGSWLLWGNenyhgfGHVsdgvpeLAIAVERRYAGHGIGPQLIDGVSEIAR 120
Cdd:TIGR01575  25 ELANYHLCYLLA---RIGGKVV--GY---AGVQIVLDE------AHI------LNIAVKPEYQGQGIGRALLRELIDEAK 84

                          90       100
                  ....*....|....*....|....*...
gi 746637318  121 AAGAPGISLSVAATNERAHRLYLRMGFE 148
Cdd:TIGR01575  85 GRGVNEIFLEVRVSNIAAQALYKKLGFN 112
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
60-165 1.16e-05

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 42.48  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746637318  60 LIAWKGHVPAG-GSWLLWGNENYHgFGHVsdgvpelaiAVERRYAGHGIGPQLIDGVSEIARAAGAPGISLSVAATnerA 138
Cdd:COG2153   37 LLAYDDGELVAtARLLPPGDGEAK-IGRV---------AVLPEYRGQGLGRALMEAAIEEARERGARRIVLSAQAH---A 103

                         90       100       110
                 ....*....|....*....|....*....|.
gi 746637318 139 HRLYLRMGFEPTGKV--VHG--HAVMLRRLA 165
Cdd:COG2153  104 VGFYEKLGFVPVGEEflEAGipHIDMRKPLS 134
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 78-151 3.38e-05

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 41.10  E-value: 3.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746637318   78 NENYHGFGHVSDGVPELAIAVERR-----------YAGHGIGPQLIDGVSEIARAAGAPGISLSVAATNErAHRLYLRMG 146
Cdd:pfam13673  28 QGEYFFFVAFEGGQIVGVIALRDRghisllfvdpdYQGQGIGKALLEAVEDYAEKDGIKLSELTVNASPY-AVPFYEKLG 106


                  ....*
gi 746637318  147 FEPTG 151
Cdd:pfam13673 107 FRATG 111
PRK10146 PRK10146
aminoalkylphosphonate N-acetyltransferase;
91-148 5.42e-04

aminoalkylphosphonate N-acetyltransferase;


Pssm-ID: 182266 [Multi-domain]  Cd Length: 144  Bit Score: 38.36  E-value: 5.42e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 746637318  91 VPELAIAVERRyaGHGIGPQLIDGVSEIARAAGAPGISLSVAATNERAHRLYLRMGFE 148
Cdd:PRK10146  79 IQELVVMPQAR--GLNVGSKLLAWAEEEARQAGAEMTELSTNVKRHDAHRFYLREGYE 134
PRK10562 PRK10562
putative acetyltransferase; Provisional
 66-155 8.33e-04

putative acetyltransferase; Provisional


Pssm-ID: 236715 [Multi-domain]  Cd Length: 145  Bit Score: 37.74  E-value: 8.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746637318  66 HVPAGGSWLLWGNENYHGFGHVSDGVPELAIAVERRYAGHGIGPQLIDGVSeiaraAGAPGISLSVAATNERAHRLYLRM 145
Cdd:PRK10562  44 YLPAAQTWVWEEDGKLLGFVSVLEGRFVGALFVAPKAVRRGIGKALMQHVQ-----QRYPHLSLEVYQKNQRAVNFYHAQ 118

                         90
                 ....*....|
gi 746637318 146 GFEPTGKVVH 155
Cdd:PRK10562 119 GFRIVDSAWQ 128
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 60-130 4.09e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 34.17  E-value: 4.09e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 746637318  60 LIAWKGHVPAGgSWLLWGNENYHGFGHVSDgvpelaIAVERRYAGHGIGPQLIDGVSEIARAAGAPGISLS 130
Cdd:cd04301    2 LVAEDDGEIVG-FASLSPDGSGGDTAYIGD------LAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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