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Conserved domains on  [gi|748672885|ref|WP_039931009|]
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phage antirepressor KilAC domain-containing protein, partial [Anaerococcus lactolyticus]

Protein Classification

KilAC family protein( domain architecture ID 10007652)

KilAC family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KilAC COG3645
Phage antirepressor protein YoqD, KilAC domain [Mobilome: prophages, transposons];
2-207 2.06e-34

Phage antirepressor protein YoqD, KilAC domain [Mobilome: prophages, transposons];


:

Pssm-ID: 442862 [Multi-domain]  Cd Length: 249  Bit Score: 122.48  E-value: 2.06e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748672885   2 VNPRKAVYDHVDEEDKGVTKWNTPGGIQNISIINESGLYSLILSSKLPQAKIFKAWVTREVLPSIRKNGGYIAGQEKKTN 81
Cdd:COG3645   27 EVRVDNESLGLGLAVKTSRRIEIRIGLVLAALESLKLVTKLVGRRLLGLPVLLELLLALAEAALLELAERLEAAVLLAKR 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748672885  82 EELLADAILVANRIIA-------------EREEENEVLRPKADYYDKLVDYNLLTNFRNTAKELGIPQNQFIRFLMDKGL 148
Cdd:COG3645  107 LAERAAERLLAAEEAEaqpelaeleeekeALEQQLAEAAPKAEFYDRIVTSKGSISVRQAAKLLGIGENRLFAWLRENGI 186

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 748672885 149 IYRDKKKKLLPYADK-NKGYFEVKEWV--DPLGT-LVGIQTFITPKGRHYLLILLDSEGFYDE 207
Cdd:COG3645  187 LYRRGSGRWLPYQKYiDAGYFEVKTGTytDPDGNeHVSTQTRVTPKGRAYLAELLAEEGALPA 249
 
Name Accession Description Interval E-value
KilAC COG3645
Phage antirepressor protein YoqD, KilAC domain [Mobilome: prophages, transposons];
2-207 2.06e-34

Phage antirepressor protein YoqD, KilAC domain [Mobilome: prophages, transposons];


Pssm-ID: 442862 [Multi-domain]  Cd Length: 249  Bit Score: 122.48  E-value: 2.06e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748672885   2 VNPRKAVYDHVDEEDKGVTKWNTPGGIQNISIINESGLYSLILSSKLPQAKIFKAWVTREVLPSIRKNGGYIAGQEKKTN 81
Cdd:COG3645   27 EVRVDNESLGLGLAVKTSRRIEIRIGLVLAALESLKLVTKLVGRRLLGLPVLLELLLALAEAALLELAERLEAAVLLAKR 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748672885  82 EELLADAILVANRIIA-------------EREEENEVLRPKADYYDKLVDYNLLTNFRNTAKELGIPQNQFIRFLMDKGL 148
Cdd:COG3645  107 LAERAAERLLAAEEAEaqpelaeleeekeALEQQLAEAAPKAEFYDRIVTSKGSISVRQAAKLLGIGENRLFAWLRENGI 186

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 748672885 149 IYRDKKKKLLPYADK-NKGYFEVKEWV--DPLGT-LVGIQTFITPKGRHYLLILLDSEGFYDE 207
Cdd:COG3645  187 LYRRGSGRWLPYQKYiDAGYFEVKTGTytDPDGNeHVSTQTRVTPKGRAYLAELLAEEGALPA 249
ANT pfam03374
Phage antirepressor protein KilAC domain; This domain was called the KilAC domain by Iyer and ...
 103-202 6.35e-27

Phage antirepressor protein KilAC domain; This domain was called the KilAC domain by Iyer and colleagues.


Pssm-ID: 460903  Cd Length: 105  Bit Score: 98.80  E-value: 6.35e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748672885  103 NEVLRPKADYYDKLVDYNLLTNFRNTAKELGIPQNQFIRFLMDKGLIYRDK-KKKLLPYADK-NKGYFEVKEWV--DPLG 178
Cdd:pfam03374   1 IAELAPKAEYADRVLDSDGSILITEIAKDLGIGQNRLFKWLRENGYLYRQKgSGRWLPYQKYmDAGYFEVKTTTytHSDG 80

                          90       100
                  ....*....|....*....|....*
gi 748672885  179 TL-VGIQTFITPKGRHYLLILLDSE 202
Cdd:pfam03374  81 SEhIKTQTKVTPKGQLFLYNLLKKE 105
Bro-N smart01040
BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI ...
 1-64 1.21e-22

BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI motif proteins. The function of BRO proteins is unknown. It has been suggested that BRO-A and BRO-C are DNA binding proteins that influence host DNA replication and/or transcription. This Pfam domain does not include the characteristic invariant alanine, leucine, isoleucine motif of the ALI proteins.


Pssm-ID: 214989  Cd Length: 89  Bit Score: 87.24  E-value: 1.21e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 748672885     1 YVNPRKAVYdHVDEEDKGVTK---WNTPGGIQNISIINESGLYSLILSSKLPQAKIFKAWVTREVLP 64
Cdd:smart01040  24 YSNPRDAIR-KLDDDEKRVAGtelLDTLGGKQEVRIISESGLYRLIMRSRKPEAKKFRRWVTDEVLP 89
8prop_hemeD1_NirF cd20778
eight-bladed heme d1-binding beta-propeller domain in cytochrome cd1 nitrate reductase NirF; ...
 66-204 1.38e-03

eight-bladed heme d1-binding beta-propeller domain in cytochrome cd1 nitrate reductase NirF; Denitrification is a process that enables biofilm formation of the opportunistic human pathogen Pseudomonas aeruginosa, making it more resilient to antibiotics and highly adaptable to different habitats. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO3- -> NO2- -> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic cytochrome cd1 (nitrite reductase) NirS via its maturation factor NirF. The nirFDLGHJE genes encode proteins required for heme d1 biosynthesis. NirS, NirF, and NirN, the monomeric dihydro-heme d1 dehydrogenase form a stable complex during nitrite reductase maturation. The nitrite reductase NirS is bound to the denitrification supercomplex via NorB, while the electron donor system NirM and the enzyme maturation machinery NirN-NirF-NirQ, interacting with NirS, are bound via NorC.


Pssm-ID: 467722 [Multi-domain]  Cd Length: 381  Bit Score: 38.80  E-value: 1.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748672885  66 IRKNGGYIA--GQEKKTNEELLADAILVANRIIAEREEENEVLRPKAdyydkLVDYnlltnfrntakelgiPQNQFIRFL 143
Cdd:cd20778   99 ISQDGRYVAvaNYDPGGVKILDADTLKVLADIPAGSKGGGQRSRVVG-----LVDA---------------PGNRFIFSL 158

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 748672885 144 MDKGLIYRDKkkkllpyaDKNKGYFEVKEWVDplgtlVGIQTF---ITPKGRHYLLILLDSEGF 204
Cdd:cd20778  159 MDADEIWVLD--------ASDPDFPVVKKFKD-----IGRMPYdalITPDGRYYIAGLFNSDGV 209
 
Name Accession Description Interval E-value
KilAC COG3645
Phage antirepressor protein YoqD, KilAC domain [Mobilome: prophages, transposons];
2-207 2.06e-34

Phage antirepressor protein YoqD, KilAC domain [Mobilome: prophages, transposons];


Pssm-ID: 442862 [Multi-domain]  Cd Length: 249  Bit Score: 122.48  E-value: 2.06e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748672885   2 VNPRKAVYDHVDEEDKGVTKWNTPGGIQNISIINESGLYSLILSSKLPQAKIFKAWVTREVLPSIRKNGGYIAGQEKKTN 81
Cdd:COG3645   27 EVRVDNESLGLGLAVKTSRRIEIRIGLVLAALESLKLVTKLVGRRLLGLPVLLELLLALAEAALLELAERLEAAVLLAKR 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748672885  82 EELLADAILVANRIIA-------------EREEENEVLRPKADYYDKLVDYNLLTNFRNTAKELGIPQNQFIRFLMDKGL 148
Cdd:COG3645  107 LAERAAERLLAAEEAEaqpelaeleeekeALEQQLAEAAPKAEFYDRIVTSKGSISVRQAAKLLGIGENRLFAWLRENGI 186

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 748672885 149 IYRDKKKKLLPYADK-NKGYFEVKEWV--DPLGT-LVGIQTFITPKGRHYLLILLDSEGFYDE 207
Cdd:COG3645  187 LYRRGSGRWLPYQKYiDAGYFEVKTGTytDPDGNeHVSTQTRVTPKGRAYLAELLAEEGALPA 249
COG3617 COG3617
Prophage antirepressor [Mobilome: prophages, transposons];
1-71 3.20e-33

Prophage antirepressor [Mobilome: prophages, transposons];


Pssm-ID: 442835  Cd Length: 106  Bit Score: 114.99  E-value: 3.20e-33
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 748672885   1 YVNPRKAVyDHVDEEDKGVTKWNTPGGIQNISIINESGLYSLILSSKLPQAKIFKAWVTREVLPSIRKNGG 71
Cdd:COG3617   37 YSNPSDAL-KHLDDDEKTKLELDTPGGPQEMLFISESGLYRLILRSRKPEAKRFKRWVTDEVLPSIRKTGS 106
ANT pfam03374
Phage antirepressor protein KilAC domain; This domain was called the KilAC domain by Iyer and ...
 103-202 6.35e-27

Phage antirepressor protein KilAC domain; This domain was called the KilAC domain by Iyer and colleagues.


Pssm-ID: 460903  Cd Length: 105  Bit Score: 98.80  E-value: 6.35e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748672885  103 NEVLRPKADYYDKLVDYNLLTNFRNTAKELGIPQNQFIRFLMDKGLIYRDK-KKKLLPYADK-NKGYFEVKEWV--DPLG 178
Cdd:pfam03374   1 IAELAPKAEYADRVLDSDGSILITEIAKDLGIGQNRLFKWLRENGYLYRQKgSGRWLPYQKYmDAGYFEVKTTTytHSDG 80

                          90       100
                  ....*....|....*....|....*
gi 748672885  179 TL-VGIQTFITPKGRHYLLILLDSE 202
Cdd:pfam03374  81 SEhIKTQTKVTPKGQLFLYNLLKKE 105
Bro-N smart01040
BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI ...
 1-64 1.21e-22

BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI motif proteins. The function of BRO proteins is unknown. It has been suggested that BRO-A and BRO-C are DNA binding proteins that influence host DNA replication and/or transcription. This Pfam domain does not include the characteristic invariant alanine, leucine, isoleucine motif of the ALI proteins.


Pssm-ID: 214989  Cd Length: 89  Bit Score: 87.24  E-value: 1.21e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 748672885     1 YVNPRKAVYdHVDEEDKGVTK---WNTPGGIQNISIINESGLYSLILSSKLPQAKIFKAWVTREVLP 64
Cdd:smart01040  24 YSNPRDAIR-KLDDDEKRVAGtelLDTLGGKQEVRIISESGLYRLIMRSRKPEAKKFRRWVTDEVLP 89
Bro-N pfam02498
BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI ...
 1-64 9.83e-19

BRO family, N-terminal domain; This family includes the N-terminus of baculovirus BRO and ALI motif proteins. The function of BRO proteins is unknown. It has been suggested that BRO-A and BRO-C are DNA binding proteins that influence host DNA replication and/or transcription. This Pfam domain does not include the characteriztic invariant alanine, leucine, isoleucine motif of the ALI proteins.


Pssm-ID: 376797  Cd Length: 96  Bit Score: 77.40  E-value: 9.83e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 748672885    1 YVNPRKAVYDHVDEEDKGVTKWN--------TPGGIQNISIINESGLYSLILSSKLPQAKIFKAWVTREVLP 64
Cdd:pfam02498  25 YTNPNKAIKKHVDKANKKCLNELvntldhedGKNGHPKTVFINEAGLYLLIMRSDKPKAEEFRKWVTQEVLP 96
8prop_hemeD1_NirF cd20778
eight-bladed heme d1-binding beta-propeller domain in cytochrome cd1 nitrate reductase NirF; ...
 66-204 1.38e-03

eight-bladed heme d1-binding beta-propeller domain in cytochrome cd1 nitrate reductase NirF; Denitrification is a process that enables biofilm formation of the opportunistic human pathogen Pseudomonas aeruginosa, making it more resilient to antibiotics and highly adaptable to different habitats. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO3- -> NO2- -> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic cytochrome cd1 (nitrite reductase) NirS via its maturation factor NirF. The nirFDLGHJE genes encode proteins required for heme d1 biosynthesis. NirS, NirF, and NirN, the monomeric dihydro-heme d1 dehydrogenase form a stable complex during nitrite reductase maturation. The nitrite reductase NirS is bound to the denitrification supercomplex via NorB, while the electron donor system NirM and the enzyme maturation machinery NirN-NirF-NirQ, interacting with NirS, are bound via NorC.


Pssm-ID: 467722 [Multi-domain]  Cd Length: 381  Bit Score: 38.80  E-value: 1.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748672885  66 IRKNGGYIA--GQEKKTNEELLADAILVANRIIAEREEENEVLRPKAdyydkLVDYnlltnfrntakelgiPQNQFIRFL 143
Cdd:cd20778   99 ISQDGRYVAvaNYDPGGVKILDADTLKVLADIPAGSKGGGQRSRVVG-----LVDA---------------PGNRFIFSL 158

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 748672885 144 MDKGLIYRDKkkkllpyaDKNKGYFEVKEWVDplgtlVGIQTF---ITPKGRHYLLILLDSEGF 204
Cdd:cd20778  159 MDADEIWVLD--------ASDPDFPVVKKFKD-----IGRMPYdalITPDGRYYIAGLFNSDGV 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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