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Conserved domains on  [gi|749014423|ref|WP_040073297|]
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MULTISPECIES: site-specific DNA-methyltransferase [Enterobacteriaceae]

Protein Classification

DNA-methyltransferase( domain architecture ID 10002921)

DNA methyltransferase catalyzes specific methylation on cytosine or adenine on both strands and protects the DNA from cleavage by endonuclease; belongs to the class I SAM-dependent methyltransferase superfamily

CATH:  2.20.25.110
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
12-335 3.58e-55

DNA modification methylase [Replication, recombination and repair];


:

Pssm-ID: 440623  Cd Length: 236  Bit Score: 180.50  E-value: 3.58e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423  12 LINADCLHFIQSLPDDSIDLIVTDPPYFKVKPNGW----DNQWKGDEDYLKWLDHCLAQFWRVLKPAGSLYLFCGHRLAS 87
Cdd:COG0863    2 LICGDCLEVLKELPDESVDLIVTDPPYNLGKKYGLgrreIGNELSFEEYLEFLREWLAECYRVLKPGGSLYVNIGDRYIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423  88 DIEIMMRE-RFNVLNHIIWAKPSGRWNGCNkeslRAYFPATERVLFaehyqgpyrgksdgyaekerelkqhimaplisyf 166
Cdd:COG0863   82 RLIAALRDaGFKLRNEIIWRKPNGVPGPSK----RRFRNSHEYILW---------------------------------- 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423 167 rdaraelgitakqiaeatgkknmvshwfgasqwqlpneadYRKlqalfsriaaekfqeqqleqphhqlvasydslNRKYS 246
Cdd:COG0863  124 ----------------------------------------FTK--------------------------------GKKYT 131

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423 247 ELLDEFKSLRRyfsvsvSVPYTDVWTHKPVQF-YPGKHPCEKPADMLRQIINASSRPGDLVADFFMGSGSTIKAAMALGR 325
Cdd:COG0863  132 FNVDAVKSIED------GRNPSDVWDIPGVTPkERKGHPTQKPVELLERLILASSNPGDIVLDPFAGSGTTLVAAERLGR 205

                        330
                 ....*....|
gi 749014423 326 RALGVELESE 335
Cdd:COG0863  206 RFIGIEIDPE 215
 
Name Accession Description Interval E-value
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
12-335 3.58e-55

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 180.50  E-value: 3.58e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423  12 LINADCLHFIQSLPDDSIDLIVTDPPYFKVKPNGW----DNQWKGDEDYLKWLDHCLAQFWRVLKPAGSLYLFCGHRLAS 87
Cdd:COG0863    2 LICGDCLEVLKELPDESVDLIVTDPPYNLGKKYGLgrreIGNELSFEEYLEFLREWLAECYRVLKPGGSLYVNIGDRYIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423  88 DIEIMMRE-RFNVLNHIIWAKPSGRWNGCNkeslRAYFPATERVLFaehyqgpyrgksdgyaekerelkqhimaplisyf 166
Cdd:COG0863   82 RLIAALRDaGFKLRNEIIWRKPNGVPGPSK----RRFRNSHEYILW---------------------------------- 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423 167 rdaraelgitakqiaeatgkknmvshwfgasqwqlpneadYRKlqalfsriaaekfqeqqleqphhqlvasydslNRKYS 246
Cdd:COG0863  124 ----------------------------------------FTK--------------------------------GKKYT 131

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423 247 ELLDEFKSLRRyfsvsvSVPYTDVWTHKPVQF-YPGKHPCEKPADMLRQIINASSRPGDLVADFFMGSGSTIKAAMALGR 325
Cdd:COG0863  132 FNVDAVKSIED------GRNPSDVWDIPGVTPkERKGHPTQKPVELLERLILASSNPGDIVLDPFAGSGTTLVAAERLGR 205

                        330
                 ....*....|
gi 749014423 326 RALGVELESE 335
Cdd:COG0863  206 RFIGIEIDPE 215
N6_N4_Mtase pfam01555
DNA methylase; Members of this family are DNA methylases. The family contains both N-4 ...
 29-342 1.00e-36

DNA methylase; Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.


Pssm-ID: 396230 [Multi-domain]  Cd Length: 221  Bit Score: 132.14  E-value: 1.00e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423   29 IDLIVTDPPYFKVKPNGWDNQWKGDEDYLKWLDHCLAQFWRVLKPAGSLYLFCGHRLASDIEIMMRE---RFNVLNHIIW 105
Cdd:pfam01555   1 VDLIVTDPPYNLGKDYGQWDDKDSIEEYLEWLEEWLKEVRRVLKPGGSIFINIGDSNIKSLKALALEilgIFKLLNDIIW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423  106 AKPSGRWNGcNKESLRayfPATERVLFaehyqgpyrgksdgYAEKERELKqhimaplisyfrdaraelgitakqiaeatg 185
Cdd:pfam01555  81 RKPNGMPNS-NGERFT---PAHEYILW--------------FSKTKKYKT------------------------------ 112

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423  186 kknmvshwFGASQWQLPNEAdyrklqalfsriaaekfqeqqleqphhqlvasYDSLNRKYSELLDEfkslrryfsvsvsv 265
Cdd:pfam01555 113 --------FNYDAIKVPYDE--------------------------------KDKLKKRGSEPNGK-------------- 138

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423  266 PYTDVWTHKPVQFYP------GKHPCEKPADMLRQIINASSRPGDLVADFFMGSGSTIKAAMALGRRALGVELESERFNQ 339
Cdd:pfam01555 139 PIGDVWDFSRVQPSEkesggnGKHPTQKPEALLERLILASTNPGDIVLDPFAGSGTTGAAAKELGRNFIGIEIEEEYVEI 218


                  ...
gi 749014423  340 TVK 342
Cdd:pfam01555 219 AKE 221
PRK11524 PRK11524
adenine-specific DNA-methyltransferase;
12-335 3.67e-22

adenine-specific DNA-methyltransferase;


Pssm-ID: 183177 [Multi-domain]  Cd Length: 284  Bit Score: 94.40  E-value: 3.67e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423  12 LINADCLHFIQSLPDDSIDLIVTDPPYFKVKP-NGWDNQWKgDEDYLKWLDHCLAQFWRVLKPAGSLYLFCGHRLASDIE 90
Cdd:PRK11524  11 IIHGDALTELKKIPSESVDLIFADPPYNIGKNfDGLIEAWK-EDLFIDWLYEWIDECHRVLKKQGTMYIMNSTENMPFID 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423  91 IMMRERFNVLNHIIWAKPSgrwNGCNKeslRAYFPAT-ERVLFAEHYQGPYRGKSDgyaekerelkqhimaplisyfrda 169
Cdd:PRK11524  90 LYCRKLFTIKSRIVWSYDS---SGVQA---KKYFGSMyEPILMMVKDAKNYTFNGD------------------------ 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423 170 raELGITAKqiaeaTGKKNMVshwfgasqwqlpneADYRKlqalfsriaaekfqeqQLEQPHHqlvasydslnrkysell 249
Cdd:PRK11524 140 --AILVEAK-----TGAKRAL--------------IDYRK----------------NPPQPYN----------------- 165

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423 250 defkslrryfsvSVSVPyTDVWTHKPVQF----YPgKHPCEKPADMLRQIINASSRPGDLVADFFMGSGSTIKAAMALGR 325
Cdd:PRK11524 166 ------------TQKVP-GNVWDFPRVRYlmdeYE-NHPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAKASGR 231

                        330
                 ....*....|
gi 749014423 326 RALGVELESE 335
Cdd:PRK11524 232 KFIGIEINSE 241
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 6-79 8.87e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 35.48  E-value: 8.87e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 749014423   6 KINSVDLINADCLHFiQSLPDDSIDLIVTDPPYFKVKpngwdnqwkgdEDYLKWLDhclaQFWRVLKPAGSLYL 79
Cdd:cd02440   45 LADNVEVLKGDAEEL-PPEADESFDVIISDPPLHHLV-----------EDLARFLE----EARRLLKPGGVLVL 102
 
Name Accession Description Interval E-value
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
12-335 3.58e-55

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 180.50  E-value: 3.58e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423  12 LINADCLHFIQSLPDDSIDLIVTDPPYFKVKPNGW----DNQWKGDEDYLKWLDHCLAQFWRVLKPAGSLYLFCGHRLAS 87
Cdd:COG0863    2 LICGDCLEVLKELPDESVDLIVTDPPYNLGKKYGLgrreIGNELSFEEYLEFLREWLAECYRVLKPGGSLYVNIGDRYIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423  88 DIEIMMRE-RFNVLNHIIWAKPSGRWNGCNkeslRAYFPATERVLFaehyqgpyrgksdgyaekerelkqhimaplisyf 166
Cdd:COG0863   82 RLIAALRDaGFKLRNEIIWRKPNGVPGPSK----RRFRNSHEYILW---------------------------------- 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423 167 rdaraelgitakqiaeatgkknmvshwfgasqwqlpneadYRKlqalfsriaaekfqeqqleqphhqlvasydslNRKYS 246
Cdd:COG0863  124 ----------------------------------------FTK--------------------------------GKKYT 131

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423 247 ELLDEFKSLRRyfsvsvSVPYTDVWTHKPVQF-YPGKHPCEKPADMLRQIINASSRPGDLVADFFMGSGSTIKAAMALGR 325
Cdd:COG0863  132 FNVDAVKSIED------GRNPSDVWDIPGVTPkERKGHPTQKPVELLERLILASSNPGDIVLDPFAGSGTTLVAAERLGR 205

                        330
                 ....*....|
gi 749014423 326 RALGVELESE 335
Cdd:COG0863  206 RFIGIEIDPE 215
N6_N4_Mtase pfam01555
DNA methylase; Members of this family are DNA methylases. The family contains both N-4 ...
 29-342 1.00e-36

DNA methylase; Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.


Pssm-ID: 396230 [Multi-domain]  Cd Length: 221  Bit Score: 132.14  E-value: 1.00e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423   29 IDLIVTDPPYFKVKPNGWDNQWKGDEDYLKWLDHCLAQFWRVLKPAGSLYLFCGHRLASDIEIMMRE---RFNVLNHIIW 105
Cdd:pfam01555   1 VDLIVTDPPYNLGKDYGQWDDKDSIEEYLEWLEEWLKEVRRVLKPGGSIFINIGDSNIKSLKALALEilgIFKLLNDIIW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423  106 AKPSGRWNGcNKESLRayfPATERVLFaehyqgpyrgksdgYAEKERELKqhimaplisyfrdaraelgitakqiaeatg 185
Cdd:pfam01555  81 RKPNGMPNS-NGERFT---PAHEYILW--------------FSKTKKYKT------------------------------ 112

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423  186 kknmvshwFGASQWQLPNEAdyrklqalfsriaaekfqeqqleqphhqlvasYDSLNRKYSELLDEfkslrryfsvsvsv 265
Cdd:pfam01555 113 --------FNYDAIKVPYDE--------------------------------KDKLKKRGSEPNGK-------------- 138

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423  266 PYTDVWTHKPVQFYP------GKHPCEKPADMLRQIINASSRPGDLVADFFMGSGSTIKAAMALGRRALGVELESERFNQ 339
Cdd:pfam01555 139 PIGDVWDFSRVQPSEkesggnGKHPTQKPEALLERLILASTNPGDIVLDPFAGSGTTGAAAKELGRNFIGIEIEEEYVEI 218


                  ...
gi 749014423  340 TVK 342
Cdd:pfam01555 219 AKE 221
PRK11524 PRK11524
adenine-specific DNA-methyltransferase;
12-335 3.67e-22

adenine-specific DNA-methyltransferase;


Pssm-ID: 183177 [Multi-domain]  Cd Length: 284  Bit Score: 94.40  E-value: 3.67e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423  12 LINADCLHFIQSLPDDSIDLIVTDPPYFKVKP-NGWDNQWKgDEDYLKWLDHCLAQFWRVLKPAGSLYLFCGHRLASDIE 90
Cdd:PRK11524  11 IIHGDALTELKKIPSESVDLIFADPPYNIGKNfDGLIEAWK-EDLFIDWLYEWIDECHRVLKKQGTMYIMNSTENMPFID 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423  91 IMMRERFNVLNHIIWAKPSgrwNGCNKeslRAYFPAT-ERVLFAEHYQGPYRGKSDgyaekerelkqhimaplisyfrda 169
Cdd:PRK11524  90 LYCRKLFTIKSRIVWSYDS---SGVQA---KKYFGSMyEPILMMVKDAKNYTFNGD------------------------ 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423 170 raELGITAKqiaeaTGKKNMVshwfgasqwqlpneADYRKlqalfsriaaekfqeqQLEQPHHqlvasydslnrkysell 249
Cdd:PRK11524 140 --AILVEAK-----TGAKRAL--------------IDYRK----------------NPPQPYN----------------- 165

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423 250 defkslrryfsvSVSVPyTDVWTHKPVQF----YPgKHPCEKPADMLRQIINASSRPGDLVADFFMGSGSTIKAAMALGR 325
Cdd:PRK11524 166 ------------TQKVP-GNVWDFPRVRYlmdeYE-NHPTQKPEALLKRIILASSNPGDIVLDPFAGSFTTGAVAKASGR 231

                        330
                 ....*....|
gi 749014423 326 RALGVELESE 335
Cdd:PRK11524 232 KFIGIEINSE 241
Mod COG2189
Adenine specific DNA methylase Mod [Replication, recombination and repair];
12-350 1.09e-12

Adenine specific DNA methylase Mod [Replication, recombination and repair];


Pssm-ID: 441792 [Multi-domain]  Cd Length: 491  Bit Score: 68.65  E-value: 1.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423  12 LINADCLHFIQSL---PDDSIDLIVTDPPYFKVKpNGW--DNQWKGDEDYL---KWLdhC-------LAQfwRVLKPAGS 76
Cdd:COG2189   39 LIEGDNLEALKLLqesYAGKVKCIYIDPPYNTGN-DFFayNDNFETESNGRfhsSWL--SmmyprlkLAR--ELLSEDGV 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423  77 LYLFCGHRLASDIEIMMRERF---NVLNHIIWAKPSGRwngcnkESLRAYF-PATERVLF----AEHYQGPYRGKSDGYA 148
Cdd:COG2189  114 IFVSIDDNEVHYLKLLLDEIFgeeNFVATIIWKKKSSG------KNDAKFFsRTHEYILVyaknKSYLKFNGLPRTEEQL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423 149 EKERELKQHIMAPlisYFRDARAELGITAKQIAEATGKKNMVSHWFGaSQWQLpNEADYRKLQALfSRIAAEKFQEQQLE 228
Cdd:COG2189  188 KRYKNPDNDPRGR---WRSVPLTAPGGRPNLFYPIEHPSTGKEVYPG-RGWRW-SKETMEELIAD-GRIYFGKDGNGVPR 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423 229 QphhqlvasydslnRKYselLDEFKSLRRYFSVSVSVPYTDVWTHKPVQFYPGKH-PCEKPADMLRQIINASSRPGDLVA 307
Cdd:COG2189  262 R-------------KRY---LDEVKKGVVPTTIWDDIGTNQNGTKELKELFGGKVfDTPKPEKLLKRIIEIATNPGDLVL 325

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 749014423 308 DFFMGSGSTIKAAMALG------RRALGVELeSERFNQTVKEVSELVGK 350
Cdd:COG2189  326 DFFAGSGTTAHAVMKLNaedggnRRFILVQL-GEYADTVTKERLRRVID 373
PRK13699 PRK13699
putative methylase; Provisional
 283-332 2.93e-10

putative methylase; Provisional


Pssm-ID: 184255  Cd Length: 227  Bit Score: 59.46  E-value: 2.93e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 749014423 283 HPCEKPADMLRQIINASSRPGDLVADFFMGSGSTIKAAMALGRRALGVEL 332
Cdd:PRK13699 144 HPTEKPVTSLQPLIESFTHPNAIVLDPFAGSGSTCVAALQSGRRYIGIEL 193
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 6-75 2.04e-05

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 44.55  E-value: 2.04e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 749014423   6 KINSVDLINADCLHFiqSLPDDSIDLIVTDPPY---FKVKPngwdnqwkgdEDYLKWLDHCLAQFWRVLKPAG 75
Cdd:COG1041   72 GYEDADVIRGDARDL--PLADESVDAIVTDPPYgrsSKISG----------EELLELYEKALEEAARVLKPGG 132
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
8-82 9.24e-05

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 43.74  E-value: 9.24e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 749014423   8 NSVDLINADCLHFIQSLPDDSIDLIVTDPPYFKVkpngwdnqwKGD---EDYLKwldhclaQFWRVLKPAGSLYLFCG 82
Cdd:COG2521  183 ERIKIILGDASEVIKTFPDESFDAIIHDPPRFSL---------AGElysLEFYR-------ELYRVLKPGGRLFHYTG 244
PRK14968 PRK14968
putative methyltransferase; Provisional
 3-99 1.64e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 41.81  E-value: 1.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749014423   3 NTVKINSVDLINADCLhfiQSLPDDSIDLIVTDPPYFKV----KPNGWDN-QWKGDEDYLKWLDHCLAQFWRVLKPAGSL 77
Cdd:PRK14968  68 NNIRNNGVEVIRSDLF---EPFRGDKFDVILFNPPYLPTeeeeEWDDWLNyALSGGKDGREVIDRFLDEVGRYLKPGGRI 144

                         90       100
                 ....*....|....*....|....*....
gi 749014423  78 YLfcghrLASD-------IEIMMRERFNV 99
Cdd:PRK14968 145 LL-----LQSSltgedevLEYLEKLGFEA 168
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 274-340 1.67e-04

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 41.86  E-value: 1.67e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 749014423 274 KPVQFYPGK-HPcekpaDMLRQIIN-ASSRPGDLVADFFMGSGSTIKAAMALGRRALGVELESERFNQT 340
Cdd:COG1041    1 MKYFFYPGSlDP-----RLARALVNlAGAKEGDTVLDPFCGTGTILIEAGLLGRRVIGSDIDPKMVEGA 64
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 10-79 1.16e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 39.74  E-value: 1.16e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 749014423  10 VDLINADCLHFIQSLPDDSIDLIVTDPPYFKV---KPNgwDNQWK------GDEDYLKWLDHClaqfWRVLKPAGSLYL 79
Cdd:COG4123   90 ITVIHGDLKEFAAELPPGSFDLVVSNPPYFKAgsgRKS--PDEARaiarheDALTLEDLIRAA----ARLLKPGGRFAL 162
COG1743 COG1743
Adenine-specific DNA methylase, contains a Zn-ribbon domain [Replication, recombination and ...
 22-39 2.91e-03

Adenine-specific DNA methylase, contains a Zn-ribbon domain [Replication, recombination and repair];


Pssm-ID: 441349 [Multi-domain]  Cd Length: 871  Bit Score: 39.54  E-value: 2.91e-03
                         10
                 ....*....|....*...
gi 749014423  22 QSLPDDSIDLIVTDPPYF 39
Cdd:COG1743  489 LPLPDGSVDAVVTDPPYY 506
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 6-79 8.87e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 35.48  E-value: 8.87e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 749014423   6 KINSVDLINADCLHFiQSLPDDSIDLIVTDPPYFKVKpngwdnqwkgdEDYLKWLDhclaQFWRVLKPAGSLYL 79
Cdd:cd02440   45 LADNVEVLKGDAEEL-PPEADESFDVIISDPPLHHLV-----------EDLARFLE----EARRLLKPGGVLVL 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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