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Conserved domains on  [gi|750335647|ref|WP_040617566|]
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GntR family transcriptional regulator [Roseibium sp. TrichSKD4]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
5-212 3.86e-60

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 187.82  E-value: 3.86e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647   5 RADLIADELEALILEGIFKDGIRLDEVQLAERFNVSRTPIREALQQLSLSGLVEQIPRRGVFVRQPGPVELLEMFEVMAE 84
Cdd:COG1802   12 LAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEVRAA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647  85 LEAVCARLAASRISDAALADLHEANARCDDAVTAQDADGYYLENERFHAILYRQSGNGFLEQECLRLYRRLQPFRRMQLR 164
Cdd:COG1802   92 LEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRLSLR 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 750335647 165 ARGRLAQSMAEHKAIVTALEQGNGDAAAIAIRGHVAVQGEKFHHLIAS 212
Cdd:COG1802  172 SPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAA 219
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
5-212 3.86e-60

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 187.82  E-value: 3.86e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647   5 RADLIADELEALILEGIFKDGIRLDEVQLAERFNVSRTPIREALQQLSLSGLVEQIPRRGVFVRQPGPVELLEMFEVMAE 84
Cdd:COG1802   12 LAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEVRAA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647  85 LEAVCARLAASRISDAALADLHEANARCDDAVTAQDADGYYLENERFHAILYRQSGNGFLEQECLRLYRRLQPFRRMQLR 164
Cdd:COG1802   92 LEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRLSLR 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 750335647 165 ARGRLAQSMAEHKAIVTALEQGNGDAAAIAIRGHVAVQGEKFHHLIAS 212
Cdd:COG1802  172 SPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAA 219
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 3-198 1.49e-22

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 91.62  E-value: 1.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647   3 RKRADLIADELEALILEGIFKDGIRL-DEVQLAERFNVSRTPIREALQQLSLSGLVEQIPRRGVFVRQPGPVELLEMFEV 81
Cdd:PRK03837  12 KKLSEEVEERLEQMIRSGEFGPGDQLpSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRPSADTIIGQLSG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647  82 MAE-------------------LEAVCARLAASRISDAALADLHEANARCDDAVtaQDADGYYLENERFHAILYRQSGNG 142
Cdd:PRK03837  92 MAKdflsqspdglahlkqarlfFESSLARYAAEHATDEQIALLRKALERNSQSL--GDNAAFIRSDMEFHRVIAEIPGNP 169

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 750335647 143 FLEQECLRLYRRLQPFRRMQLRARGRLAQSMAEHKAIVTALEQGNGDAAAIAIRGH 198
Cdd:PRK03837 170 IFMAIHEALLDWLIEARPEVVILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSH 225
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 77-196 3.18e-21

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 84.73  E-value: 3.18e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647   77 EMFEVMAELEAVCARLAASRISDAALADLHEANARCDDAVTAQDADGYYLENERFHAILYRQSGNGFLEQECLRLYRRLQ 156
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 750335647  157 PFRRMQLRARGRLAQSMAEHKAIVTALEQGNGDAAAIAIR 196
Cdd:pfam07729  81 RLRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMR 120
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 77-200 1.51e-19

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 80.48  E-value: 1.51e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647    77 EMFEVMAELEAVCARLAASRISDAALADLHEANARCDDAVTAQDADGYYLE-NERFHAILYRQSGNGFLEQECLRLYRRL 155
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGDDLEEFAElDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 750335647   156 QPFRRMQLRARGRLAQsmaEHKAIVTALEQGNGDAAAIAIRGHVA 200
Cdd:smart00895  81 RRLRRLSLEAARRALD---EHRAILDAIRARDAEAARAAMREHLE 122
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 4-68 5.02e-17

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 72.09  E-value: 5.02e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 750335647   4 KRADLIADELEALILEGIFKDGIRLD-EVQLAERFNVSRTPIREALQQLSLSGLVEQIPRRGVFVR 68
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
5-212 3.86e-60

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 187.82  E-value: 3.86e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647   5 RADLIADELEALILEGIFKDGIRLDEVQLAERFNVSRTPIREALQQLSLSGLVEQIPRRGVFVRQPGPVELLEMFEVMAE 84
Cdd:COG1802   12 LAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEVRAA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647  85 LEAVCARLAASRISDAALADLHEANARCDDAVTAQDADGYYLENERFHAILYRQSGNGFLEQECLRLYRRLQPFRRMQLR 164
Cdd:COG1802   92 LEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRLSLR 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 750335647 165 ARGRLAQSMAEHKAIVTALEQGNGDAAAIAIRGHVAVQGEKFHHLIAS 212
Cdd:COG1802  172 SPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAA 219
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
3-200 1.18e-39

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 135.83  E-value: 1.18e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647   3 RKRADLIADELEALILEGIFKDGIRLD-EVQLAERFNVSRTPIREALQQLSLSGLVEQIPRRGVFVRQPGP--------- 72
Cdd:COG2186    6 RSLAEQVAEQLRELILSGELKPGDRLPsERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPwalldplal 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647  73 ------VELLEMFEVMAELEAVCARLAASRISDAALADLHEANARCDDAVTaqDADGYYLENERFHAILYRQSGNGFLEQ 146
Cdd:COG2186   86 llalddASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAAD--DGEAFAEADLAFHRAIAEASGNPLLAL 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 750335647 147 ECLRLYRRLQPFRRMQLRARGRLAQSMAEHKAIVTALEQGNGDAAAIAIRGHVA 200
Cdd:COG2186  164 LLESLRELLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLE 217
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 3-198 1.49e-22

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 91.62  E-value: 1.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647   3 RKRADLIADELEALILEGIFKDGIRL-DEVQLAERFNVSRTPIREALQQLSLSGLVEQIPRRGVFVRQPGPVELLEMFEV 81
Cdd:PRK03837  12 KKLSEEVEERLEQMIRSGEFGPGDQLpSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRPSADTIIGQLSG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647  82 MAE-------------------LEAVCARLAASRISDAALADLHEANARCDDAVtaQDADGYYLENERFHAILYRQSGNG 142
Cdd:PRK03837  92 MAKdflsqspdglahlkqarlfFESSLARYAAEHATDEQIALLRKALERNSQSL--GDNAAFIRSDMEFHRVIAEIPGNP 169

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 750335647 143 FLEQECLRLYRRLQPFRRMQLRARGRLAQSMAEHKAIVTALEQGNGDAAAIAIRGH 198
Cdd:PRK03837 170 IFMAIHEALLDWLIEARPEVVILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSH 225
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 77-196 3.18e-21

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 84.73  E-value: 3.18e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647   77 EMFEVMAELEAVCARLAASRISDAALADLHEANARCDDAVTAQDADGYYLENERFHAILYRQSGNGFLEQECLRLYRRLQ 156
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 750335647  157 PFRRMQLRARGRLAQSMAEHKAIVTALEQGNGDAAAIAIR 196
Cdd:pfam07729  81 RLRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMR 120
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 77-200 1.51e-19

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 80.48  E-value: 1.51e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647    77 EMFEVMAELEAVCARLAASRISDAALADLHEANARCDDAVTAQDADGYYLE-NERFHAILYRQSGNGFLEQECLRLYRRL 155
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGDDLEEFAElDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 750335647   156 QPFRRMQLRARGRLAQsmaEHKAIVTALEQGNGDAAAIAIRGHVA 200
Cdd:smart00895  81 RRLRRLSLEAARRALD---EHRAILDAIRARDAEAARAAMREHLE 122
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 4-68 5.02e-17

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 72.09  E-value: 5.02e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 750335647   4 KRADLIADELEALILEGIFKDGIRLD-EVQLAERFNVSRTPIREALQQLSLSGLVEQIPRRGVFVR 68
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 3-200 1.65e-14

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 70.18  E-value: 1.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647   3 RKRADLIADELEALILEGIFKDGIRLD-EVQLAERFNVSRTPIREALQQLSLSGLVeqIPRR--GVFVRQP--------- 70
Cdd:PRK10421   1 RRLSDEVADRVRALIEEKNLEAGMKLPaERQLAMQLGVSRNSLREALAKLVSEGVL--LSRRggGTFIRWRhetwseqni 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647  71 -GPVELL---------EMFEVMAELEAVCARLAASRISDAALADLHeanaRCDDAVTAQDADGYYLENERFHAILYRQSG 140
Cdd:PRK10421  79 vQPLKTLmaddpdysfDILEARHAIEASTAWHAAMRATPGDKEKIQ----LCFEATLSEDPDLASQADVRFHLAIAEASH 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 750335647 141 NGFLEQECLRLYRRLQPF----RRMQLRARGRLAQSMAEHKAIVTALEQGNGDAAAIAIRGHVA 200
Cdd:PRK10421 155 NVVLLQTMRGFFDVLQSSvkqsRQRMYLVPPVFSQLTEQHQAVMDAILAGDAEGARKAMMAHLS 218
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
9-70 1.82e-14

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 69.51  E-value: 1.82e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 750335647   9 IADELEALILEGIFKDGIRL-DEVQLAERFNVSRTPIREALQQLSLSGLVEQIPRRGVFVRQP 70
Cdd:COG2188   10 IADALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEP 72
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 9-67 6.91e-13

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 61.48  E-value: 6.91e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647    9 IADELEALILEGIFKDGIRLDEVQ-LAERFNVSRTPIREALQQLSLSGLVEQIPRRGVFV 67
Cdd:pfam00392   5 VYARLREDILSGRLRPGDKLPSEReLAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
9-67 1.02e-12

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 60.67  E-value: 1.02e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647     9 IADELEALILEGIFKDGIRLD-EVQLAERFNVSRTPIREALQQLSLSGLVEQIPRRGVFV 67
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPsERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 2-100 3.12e-11

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 60.94  E-value: 3.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647   2 DRKRADLIADELEALILEGIFKDGIRL-DEVQLAERFNVSRTPIREALQQLSLSGLVEQIPRRGVFV----RQPG----- 71
Cdd:PRK09990   5 RRPIADVVAERIERLIVDGVLKVGQALpSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVarlnRVQDasplm 84

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 750335647  72 ------PVELLEMFEVMAELEAVCARLAASRISDA 100
Cdd:PRK09990  85 hlfssqPRTLYDLLEVRALLEGESARLAALRGTQA 119
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 17-199 7.92e-10

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 56.83  E-value: 7.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647  17 ILEGIFKDGIRLDEVQLAERFNVSRTPIREALQQLSLSGLVEQIPRRGVFVRQPGPVELLEMFEVMAELEAVCARLAASR 96
Cdd:PRK11534  20 IIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMEAMLVSLAIAR 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647  97 ISDAALADLhEANARCDDAVTAQDA-----DGYYLENERFHAILYRQSGNGFLEQECLRLYRRLQPFRRMQLRARGRLAQ 171
Cdd:PRK11534 100 GGDEWEADV-LAKAHLLSKLEACDAsekmlDEWDLRHQAFHTAIVAGCGSHYLLQMRERLFDLAARYRFIWLRRTVLSVE 178

                        170       180       190
                 ....*....|....*....|....*....|..
gi 750335647 172 SMA----EHKAIVTALEQGNGDAAAIAIRGHV 199
Cdd:PRK11534 179 MLEdkhdQHQTLTAAILARDTARASELMRQHL 210
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
4-123 9.39e-09

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 53.87  E-value: 9.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647   4 KRADLIADELEALILEGIFKDGIRL-DEVQLAERFNVSRTPIREALQQLSLSGLVEQIPRRGVFVRQ------PGP-VEL 75
Cdd:PRK09464  10 KLSDVIEQQLEFLILEGTLRPGEKLpPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSslwqsfSDPlVEL 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 750335647  76 L--------EMFEVMAELEAVCARLAASRISDAALADLHEANARCDDAVTAQDADG 123
Cdd:PRK09464  90 LsdhpesqfDLLETRHALEGIAAYYAALRGTDEDFERIRECHHAIELAQQSGDLDA 145
PRK10225 PRK10225
Uxu operon transcriptional regulator;
16-199 9.60e-09

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 53.87  E-value: 9.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647  16 LILEGIFKDGIRLD-EVQLAERFNVSRTPIREALQQLSLSGLVEQIPRRGVFV-----------------RQPGPVELLE 77
Cdd:PRK10225  21 LIIKTPYNPGERLPpEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVldssgshntdspdanvcNDAGPFELLQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647  78 MFEVmaeLEAVCARLAASRISDAALADLHEANARCDDAVTAQDADGYYLENERFHAILYRQSGNGFLeqecLRLYRRLQP 157
Cdd:PRK10225 101 ARQL---LESNIAEFAALQATREDIVKMRQALQLEERELASSAPGSSESGDMQFHLAIAEATHNSML----VELFRQSWQ 173

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 750335647 158 FRR---MQLRARGRLAQS------MAEHKAIVTALEQGNGDAAAIAIRGHV 199
Cdd:PRK10225 174 WREnnpMWIQLHSHLDDSlyrkewLGDHKQILAALIKKDARAAKLAMWQHL 224
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 1-77 4.08e-08

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 52.52  E-value: 4.08e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 750335647   1 MDRKRADLIADELEALILEGIFKDGIRLDEV-QLAERFNVSRTPIREALQQLSLSGLVEQIPRRGVFVRQPGPVELLE 77
Cdd:COG1167    9 SSGPLYLQLADALREAILSGRLPPGDRLPSSrELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARLPAPAPA 86
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
9-105 8.17e-07

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 46.33  E-value: 8.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647   9 IADELEALILEGIFKDGIRLDEV-QLAERFNVSRTPIREALQQLSLSGLVEQIPRRGVFVRQPGPVELLEMFE--VMAEL 85
Cdd:COG1725   15 IADQIKEAIASGELKPGDRLPSVrELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARELLEERREefLEEAL 94

                         90       100
                 ....*....|....*....|
gi 750335647  86 EAVCARLAASRISDAALADL 105
Cdd:COG1725   95 RELVAEARRLGLSLEELLEL 114
PRK11414 PRK11414
GntR family transcriptional regulator;
20-157 3.99e-06

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 46.02  E-value: 3.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647  20 GIFKDGIRLDEVQLAERFNVSRTPIREALQQLSLSGLVEQIPRRGVFVRQPGPVELLEMFEVMAELEAVCARLAASRISD 99
Cdd:PRK11414  27 GALKPGARLITKNLAEQLGMSITPVREALLRLVSVNALSVAPAQAFTVPEVSKRQLDEINRIRYELELMAVALAVENLTP 106

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 750335647 100 AALADLHEANARCDDAVTAQDADGYYLENERFHAILYRQSGNGFLEQECLRLYRRLQP 157
Cdd:PRK11414 107 QDLAELQELLEKLQQAQEKGDMEQIINANRLFRLAIYHRSNMPILCEMIEQLWVRMGP 164
PRK09764 PRK09764
GntR family transcriptional regulator;
9-69 6.33e-05

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 42.51  E-value: 6.33e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 750335647   9 IADELEALILEGIFKDGIRL-DEVQLAERFNVSRTPIREALQQLSLSGLVEQIPRRGVFVRQ 69
Cdd:PRK09764  10 IADRIREQIARGELKPGDALpTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKE 71
PRK11523 PRK11523
transcriptional regulator ExuR;
9-114 7.15e-04

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 39.44  E-value: 7.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750335647   9 IADELEALILEGIFKDGIRLD-EVQLAERFNVSRTPIREALQQLSLSGLVEQIPRRGVFV--RQP--------------- 70
Cdd:PRK11523  13 LAAELKERIEQGVYLVGDKLPaERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVvsNQPrhqqaadnnmefany 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 750335647  71 GPVELLEMFEVmaeLEAVCARLAASRISDAALADLHE--ANARCDD 114
Cdd:PRK11523  93 GPFELLQARQL---IESNIAEFAATQVTKQDIMKLMAiqEQARGED 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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