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Conserved domains on  [gi|751581042|ref|WP_041049727|]
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carbonic anhydrase [Helicobacter pylori]

Protein Classification

carbonic anhydrase( domain architecture ID 10790132)

carbonic anhydrase catalyzes the reversible hydration of gaseous carbon dioxide to carbonic acid

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
1-242 6.60e-83

Carbonic anhydrase [Inorganic ion transport and metabolism];


:

Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 247.87  E-value: 6.60e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042   1 MKKTFLIALVLAASLI-----GAENTKWDYKNkENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKtDLQFKYAAS 75
Cdd:COG3338    1 MKKRLLLALLLAAALPaaaaaAASAPHWSYEG-ETGPEHWGELSPEFATCATGKNQSPIDIRTAIKADLP-PLKFDYKPT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  76 kPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSTHFVHKDAKGRLLVLAIGFEEGKENPNL 155
Cdd:COG3338   79 -PLEIVNNGHTIQVNVDPGSTLTVDGKRYELKQFHFHTPSEHTINGKSYPMEAHLVHKDADGELAVVGVLFEEGAENPAL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 156 DPILEGIQKKQNFKEVA-----LDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMknSPNQRP 230
Cdd:COG3338  158 AKLWANLPLEAGEEVALdatidLNDLLPEDRSYYRYSGSLTTPPCSEGVLWIVLKQPITVSAEQIEAFARLY--PNNARP 235
                        250
                 ....*....|..
gi 751581042 231 VQPDYNTVIIKS 242
Cdd:COG3338  236 VQPLNGRLILES 247
 
Name Accession Description Interval E-value
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
1-242 6.60e-83

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 247.87  E-value: 6.60e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042   1 MKKTFLIALVLAASLI-----GAENTKWDYKNkENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKtDLQFKYAAS 75
Cdd:COG3338    1 MKKRLLLALLLAAALPaaaaaAASAPHWSYEG-ETGPEHWGELSPEFATCATGKNQSPIDIRTAIKADLP-PLKFDYKPT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  76 kPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSTHFVHKDAKGRLLVLAIGFEEGKENPNL 155
Cdd:COG3338   79 -PLEIVNNGHTIQVNVDPGSTLTVDGKRYELKQFHFHTPSEHTINGKSYPMEAHLVHKDADGELAVVGVLFEEGAENPAL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 156 DPILEGIQKKQNFKEVA-----LDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMknSPNQRP 230
Cdd:COG3338  158 AKLWANLPLEAGEEVALdatidLNDLLPEDRSYYRYSGSLTTPPCSEGVLWIVLKQPITVSAEQIEAFARLY--PNNARP 235
                        250
                 ....*....|..
gi 751581042 231 VQPDYNTVIIKS 242
Cdd:COG3338  236 VQPLNGRLILES 247
alpha_CA_prokaryotic_like cd03124
Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are ...
31-241 2.30e-78

Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This sub-family includes bacterial carbonic anhydrase alpha, as well as plant enzymes such as tobacco nectarin III and yam dioscorin and, carbonic anhydrases from molluscs, such as nacrein, which are part of the organic matrix layer in shells. Other members of this family may be involved in maintaining pH balance, in facilitating transport of carbon dioxide or carbonic acid, or in sensing carbon dioxide levels in the environment. Dioscorin is the major storage protein of yam tubers and may play a role as an antioxidant. Tobacco Nectarin may play a role in the maintenace of pH and oxidative balance in nectar. Mollusc nacrein may participate in calcium carbonate crystal formation of the nacreous layer. This subfamily also includes three alpha carbonic anhydrases from Chlamydomonas reinhardtii (CAH 1-3). CAHs1-2 are localized in the periplasmic space. CAH1 faciliates the movement of carbon dioxide across the plasma membrane when the medium is alkaline. CAH3 is localized to the thylakoid lumen and provides CO2 to Rubisco.


Pssm-ID: 239398 [Multi-domain]  Cd Length: 216  Bit Score: 235.24  E-value: 2.30e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  31 GPHRWDKLHKDFEVCKSGKSQSPINIEHYyHTQDKTDLQFKYAAS-KPKAVFFTHHTLKASFEPT-NHINYRGHDYVLDN 108
Cdd:cd03124    1 GPEHWGNLDPEFALCATGKNQSPIDITTK-AVVSDKLPPLNYNYKpTSATLVNNGHTIQVNFEGNgGTLTIDGETYQLLQ 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 109 VHFHAPMEFLINNKTRPLSTHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKE-----VALDAFLPKSINY 183
Cdd:cd03124   80 FHFHSPSEHLINGKRYPLEAHLVHKSKDGQLAVVAVLFEEGKENPFLKKILDNMPKKEGTEVnlpaiLDPNELLPESRSY 159
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 751581042 184 YHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNsPNQRPVQPDYNTVIIK 241
Cdd:cd03124  160 YRYEGSLTTPPCSEGVRWIVLKQPITISKEQLAKFRAAVYP-NNARPVQPLNGREVLL 216
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
23-236 1.83e-54

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 175.58  E-value: 1.83e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042    23 WDYKNKeNGPHRWDKLHKDfevCKSGKSQSPINIEHYYHTQDK--TDLQFKYAASKPKAVFFTHHTLKASFEPtNHINYR 100
Cdd:smart01057   1 WGYEGK-NGPEHWGKLDPP---FCGGKRQSPIDIVTAEAQYDPslKPLKLSYDQPTAKRILNNGHTVQVNFDD-DGSTLS 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042   101 G----HDYVLDNVHFHAP------MEFLINNKTRPLSTHFVHKDAK----------GRLLVLAIGFEEGKE-NPNLDPIL 159
Cdd:smart01057  76 GgplpGRYRLKQFHFHWGgsdsegSEHTIDGKRFPLELHLVHYNSKgsfseavskpGGLAVVAVFFKVGAEeNPALQAIL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042   160 EGIQK-KQNFKEVALDAF-----LPKSI-NYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSP------ 226
Cdd:smart01057 156 DHLPLiKYKGQETELTPFdlsslLPASTrHYYTYNGSLTTPPCSEGVTWIVFKEPITISTEQLEKFRTLLPMEGneplvn 235
                          250
                   ....*....|
gi 751581042   227 NQRPVQPDYN 236
Cdd:smart01057 236 NARPLQPLNG 245
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
30-242 4.09e-38

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 133.55  E-value: 4.09e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042   30 NGPHRWdklHKDFEVCKsGKSQSPINIEHYYHTQDKT--DLQFKYAASKPKAVFF--THHTLKASFEPTNHINYRG---- 101
Cdd:pfam00194   1 LGPEHW---GKVYPSCG-GKRQSPINIDTRKVRYDPSlpPLTFQGYDVPPGKNTLtnNGHTVQVSLDDGDPSTISGgpla 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  102 HDYVLDNVHFH--APM----EFLINNKTRPLSTHFVH-----------KDAKGRLLVLAIGFEEGKE-NPNLDPILEGIQ 163
Cdd:pfam00194  77 TRYRLVQFHFHwgSTDsrgsEHTIDGKRYPAELHIVHynskyksfdeaAKHPDGLAVLGVFFEVGDEnNPYLQPIVSALD 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  164 K------KQNFKEVALDAFLPKSI-NYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLA-----------EIKKRMKNs 225
Cdd:pfam00194 157 NikykgkSVLLPPFDLSDLLPEDLtSYYTYNGSLTTPPCSESVTWIVFKEPISISEEQLEafrtllfsdggEEPRPLVN- 235
                         250
                  ....*....|....*..
gi 751581042  226 pNQRPVQPDYNTVIIKS 242
Cdd:pfam00194 236 -NFRPTQPLNGRVVFAS 251
PLN02179 PLN02179
carbonic anhydrase
21-205 3.12e-28

carbonic anhydrase


Pssm-ID: 177835  Cd Length: 235  Bit Score: 107.37  E-value: 3.12e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  21 TKWDYKNK-ENGPHRWDKLHKDFEVCKSGKSQSPINIehyyhTQDKTDLQFKYAAS---KPKAVFFT---HHTLKASFEP 93
Cdd:PLN02179  35 PLFTYKQKtEKGPAEWGKLNPQWKVCSTGKYQSPIDL-----TDERVSLIHDQALSrhyKPAPAVIQsrgHDVMVSWKGD 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  94 TNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSTHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNfKEVAL 173
Cdd:PLN02179 110 AGKITIHQTDYKLVQCHWHSPSEHTINGTSYDLELHMVHTSASGKTAVVGVLYKLGEPDEFLTKLLNGIKGVGK-KEINL 188
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 751581042 174 DAFLPKSI-----NYYHFNGSLTAPPCTEGVAWFVIE 205
Cdd:PLN02179 189 GIVDPRDIrfetnNFYRYIGSLTIPPCTEGVIWTVVK 225
 
Name Accession Description Interval E-value
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
1-242 6.60e-83

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 247.87  E-value: 6.60e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042   1 MKKTFLIALVLAASLI-----GAENTKWDYKNkENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKtDLQFKYAAS 75
Cdd:COG3338    1 MKKRLLLALLLAAALPaaaaaAASAPHWSYEG-ETGPEHWGELSPEFATCATGKNQSPIDIRTAIKADLP-PLKFDYKPT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  76 kPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSTHFVHKDAKGRLLVLAIGFEEGKENPNL 155
Cdd:COG3338   79 -PLEIVNNGHTIQVNVDPGSTLTVDGKRYELKQFHFHTPSEHTINGKSYPMEAHLVHKDADGELAVVGVLFEEGAENPAL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 156 DPILEGIQKKQNFKEVA-----LDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMknSPNQRP 230
Cdd:COG3338  158 AKLWANLPLEAGEEVALdatidLNDLLPEDRSYYRYSGSLTTPPCSEGVLWIVLKQPITVSAEQIEAFARLY--PNNARP 235
                        250
                 ....*....|..
gi 751581042 231 VQPDYNTVIIKS 242
Cdd:COG3338  236 VQPLNGRLILES 247
alpha_CA_prokaryotic_like cd03124
Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are ...
31-241 2.30e-78

Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This sub-family includes bacterial carbonic anhydrase alpha, as well as plant enzymes such as tobacco nectarin III and yam dioscorin and, carbonic anhydrases from molluscs, such as nacrein, which are part of the organic matrix layer in shells. Other members of this family may be involved in maintaining pH balance, in facilitating transport of carbon dioxide or carbonic acid, or in sensing carbon dioxide levels in the environment. Dioscorin is the major storage protein of yam tubers and may play a role as an antioxidant. Tobacco Nectarin may play a role in the maintenace of pH and oxidative balance in nectar. Mollusc nacrein may participate in calcium carbonate crystal formation of the nacreous layer. This subfamily also includes three alpha carbonic anhydrases from Chlamydomonas reinhardtii (CAH 1-3). CAHs1-2 are localized in the periplasmic space. CAH1 faciliates the movement of carbon dioxide across the plasma membrane when the medium is alkaline. CAH3 is localized to the thylakoid lumen and provides CO2 to Rubisco.


Pssm-ID: 239398 [Multi-domain]  Cd Length: 216  Bit Score: 235.24  E-value: 2.30e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  31 GPHRWDKLHKDFEVCKSGKSQSPINIEHYyHTQDKTDLQFKYAAS-KPKAVFFTHHTLKASFEPT-NHINYRGHDYVLDN 108
Cdd:cd03124    1 GPEHWGNLDPEFALCATGKNQSPIDITTK-AVVSDKLPPLNYNYKpTSATLVNNGHTIQVNFEGNgGTLTIDGETYQLLQ 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 109 VHFHAPMEFLINNKTRPLSTHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKE-----VALDAFLPKSINY 183
Cdd:cd03124   80 FHFHSPSEHLINGKRYPLEAHLVHKSKDGQLAVVAVLFEEGKENPFLKKILDNMPKKEGTEVnlpaiLDPNELLPESRSY 159
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 751581042 184 YHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNsPNQRPVQPDYNTVIIK 241
Cdd:cd03124  160 YRYEGSLTTPPCSEGVRWIVLKQPITISKEQLAKFRAAVYP-NNARPVQPLNGREVLL 216
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
23-236 1.83e-54

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 175.58  E-value: 1.83e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042    23 WDYKNKeNGPHRWDKLHKDfevCKSGKSQSPINIEHYYHTQDK--TDLQFKYAASKPKAVFFTHHTLKASFEPtNHINYR 100
Cdd:smart01057   1 WGYEGK-NGPEHWGKLDPP---FCGGKRQSPIDIVTAEAQYDPslKPLKLSYDQPTAKRILNNGHTVQVNFDD-DGSTLS 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042   101 G----HDYVLDNVHFHAP------MEFLINNKTRPLSTHFVHKDAK----------GRLLVLAIGFEEGKE-NPNLDPIL 159
Cdd:smart01057  76 GgplpGRYRLKQFHFHWGgsdsegSEHTIDGKRFPLELHLVHYNSKgsfseavskpGGLAVVAVFFKVGAEeNPALQAIL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042   160 EGIQK-KQNFKEVALDAF-----LPKSI-NYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSP------ 226
Cdd:smart01057 156 DHLPLiKYKGQETELTPFdlsslLPASTrHYYTYNGSLTTPPCSEGVTWIVFKEPITISTEQLEKFRTLLPMEGneplvn 235
                          250
                   ....*....|
gi 751581042   227 NQRPVQPDYN 236
Cdd:smart01057 236 NARPLQPLNG 245
alpha_CA cd00326
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
48-240 7.83e-51

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


Pssm-ID: 238200  Cd Length: 227  Bit Score: 165.53  E-value: 7.83e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  48 GKSQSPINIEHYyHTQDKTDLQ---FKYAASKPKAVFFTHHTLKASFE---PTNHINYRGHDYVLDNVHFHA------PM 115
Cdd:cd00326    1 GKRQSPINIVTS-AVVYDPSLPplnFDYYPTTSLTLVNNGHTVQVNFDddgGTLSGGGLPGRYKLVQFHFHWgsenspGS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 116 EFLINNKTRPLSTHFVHKDAK----------GRLLVLAIGFEEG-KENPNLDPILEGIQKKQ------NFKEVALDAFLP 178
Cdd:cd00326   80 EHTIDGKRYPLELHLVHYNSDyysseaakkpGGLAVLGVFFEVGeKENPFLKKILDALPKIKykgketTLPPFDLSDLLP 159
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 751581042 179 KSI-NYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSP-----NQRPVQPDYNTVII 240
Cdd:cd00326  160 SSLrDYYTYEGSLTTPPCSEGVTWIVFKEPITISKEQLEAFRSLLDREGkplvnNYRPVQPLNGRVVY 227
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
30-242 4.09e-38

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 133.55  E-value: 4.09e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042   30 NGPHRWdklHKDFEVCKsGKSQSPINIEHYYHTQDKT--DLQFKYAASKPKAVFF--THHTLKASFEPTNHINYRG---- 101
Cdd:pfam00194   1 LGPEHW---GKVYPSCG-GKRQSPINIDTRKVRYDPSlpPLTFQGYDVPPGKNTLtnNGHTVQVSLDDGDPSTISGgpla 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  102 HDYVLDNVHFH--APM----EFLINNKTRPLSTHFVH-----------KDAKGRLLVLAIGFEEGKE-NPNLDPILEGIQ 163
Cdd:pfam00194  77 TRYRLVQFHFHwgSTDsrgsEHTIDGKRYPAELHIVHynskyksfdeaAKHPDGLAVLGVFFEVGDEnNPYLQPIVSALD 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  164 K------KQNFKEVALDAFLPKSI-NYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLA-----------EIKKRMKNs 225
Cdd:pfam00194 157 NikykgkSVLLPPFDLSDLLPEDLtSYYTYNGSLTTPPCSESVTWIVFKEPISISEEQLEafrtllfsdggEEPRPLVN- 235
                         250
                  ....*....|....*..
gi 751581042  226 pNQRPVQPDYNTVIIKS 242
Cdd:pfam00194 236 -NFRPTQPLNGRVVFAS 251
PLN02179 PLN02179
carbonic anhydrase
21-205 3.12e-28

carbonic anhydrase


Pssm-ID: 177835  Cd Length: 235  Bit Score: 107.37  E-value: 3.12e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  21 TKWDYKNK-ENGPHRWDKLHKDFEVCKSGKSQSPINIehyyhTQDKTDLQFKYAAS---KPKAVFFT---HHTLKASFEP 93
Cdd:PLN02179  35 PLFTYKQKtEKGPAEWGKLNPQWKVCSTGKYQSPIDL-----TDERVSLIHDQALSrhyKPAPAVIQsrgHDVMVSWKGD 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  94 TNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSTHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNfKEVAL 173
Cdd:PLN02179 110 AGKITIHQTDYKLVQCHWHSPSEHTINGTSYDLELHMVHTSASGKTAVVGVLYKLGEPDEFLTKLLNGIKGVGK-KEINL 188
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 751581042 174 DAFLPKSI-----NYYHFNGSLTAPPCTEGVAWFVIE 205
Cdd:PLN02179 189 GIVDPRDIrfetnNFYRYIGSLTIPPCTEGVIWTVVK 225
alpha_CA_I_II_III_XIII cd03119
Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are ...
23-233 2.08e-25

Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozymes I, II, and III, which are cytoplasmic enzymes. CA I, for example, is expressed in erythrocyes of many vertebrates; CA II is the most active cytosolic isozyme; while it is being expressed nearly ubiquitously, it comprises 95% of the renal carbonic anhydrase and is required for renal acidification; CA III has been implicated in protection from the damaging effect of oxidizing agents in hepatocytes. CAXIII may play important physiological roles in several organs.


Pssm-ID: 239393 [Multi-domain]  Cd Length: 259  Bit Score: 100.21  E-value: 2.08e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  23 WDYkNKENGPHRWdklHKDFEVCKsGKSQSPINIehyyHTQD-KTD-----LQFKYAASKPKAVFFTHHTLKASFEPT-N 95
Cdd:cd03119    5 WGY-DSHNGPEHW---HELFPIAK-GDRQSPIDI----KTKDaKHDpslkpLSVSYDPATAKTILNNGHSFNVEFDDTdD 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  96 HINYRG----HDYVLDNVHFH------APMEFLINNKTRPLSTHFVHKDAK-----------GRLLVLAIGFEEGKENPN 154
Cdd:cd03119   76 RSVLRGgpltGSYRLRQFHFHwgssddHGSEHTVDGVKYAAELHLVHWNSKygsfgeaakqpDGLAVVGVFLKVGEANPE 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 155 LDPILEGIQK-KQNFKEVALDAF-----LPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSP-- 226
Cdd:cd03119  156 LQKVLDALDSiKTKGKQAPFTNFdpsclLPASLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQMAKFRSLLFNAEge 235
                        250
                 ....*....|....
gi 751581042 227 -------NQRPVQP 233
Cdd:cd03119  236 ppcpmvdNWRPPQP 249
alpha_CARP_receptor_like cd03122
Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related ...
31-233 2.16e-24

Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. This sub-family of carbonic anhydrase-related domains found in tyrosine phosphatase receptors may play a role in cell adhesion.


Pssm-ID: 239396 [Multi-domain]  Cd Length: 253  Bit Score: 97.43  E-value: 2.16e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  31 GPHRWDKLhkdFEVCKSGKSQSPINIEHYYH--TQDKTDLQFKYAASKPKAVFFTH--HTL-----KASFEPTnhinYRG 101
Cdd:cd03122    1 NPKHWAKK---YPACGEGRQQSPIDIVEDTQvqRQGLQPLHFDGYEELTASTTLENtgKTVilrleGNSSDPF----VSG 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 102 HD----YVLDNVHFH---APM---EFLINNKTRPLSTHFVHKDAK-----------GRLLVLAIGFEEG-KENPNLDPIL 159
Cdd:cd03122   74 GPllgrYKFSEITFHwgtCNSdgsEHSIDGHKFPLEMQILHRNTDffdsfeaikspGGVLALAYLFELShEDNPFLDPII 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 160 EGIQKKQNF-KEVALDAF-----LPKSI-NYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAE--------------I 218
Cdd:cd03122  154 EGLRNVSRPgKEVELPPFplsdlLPPFTdKYYSYEGSLTTPPCSETVEWIVFREPVPISSRQLEAfrelltrrqdgvmsG 233
                        250
                 ....*....|....*
gi 751581042 219 KKRMKNSpnqRPVQP 233
Cdd:cd03122  234 DYLPNNG---RPQQP 245
alpha_CA_VI_IX_XII_XIV cd03123
Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are ...
40-239 8.47e-23

Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are mostly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva, for example, and the membrane proteins CA IX, XII, and XIV.


Pssm-ID: 239397 [Multi-domain]  Cd Length: 248  Bit Score: 93.14  E-value: 8.47e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  40 KDFEVCkSGKSQSPINI--EHYYHTQDKTDLQFK-YAASKPKAVFFTH--HTLKASFEPTNHI-NYRGHDYVLDNVHFH- 112
Cdd:cd03123    7 KKYPAC-GGKRQSPIDIqtDIVQFDPSLPPLELVgYDLPGTEEFTLTNngHTVQLSLPPTMHIrGGPGTEYTAAQLHLHw 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 113 ------APMEFLINNKTRPLSTHFVH------------KDAKGRLLVLAIGFEEG-KENPNLDPI---LEGIQKKQNFKE 170
Cdd:cd03123   86 ggrgslSGSEHTIDGIRFAAELHIVHynsdkyssfdeaADKPDGLAVLAILIEVGyPENTYYEKIishLHEIKYKGQETT 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 171 VA---LDAFLPKSIN-YYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIK--------KRMKNspNQRPVQPDYNTV 238
Cdd:cd03123  166 VPgfnVRELLPEDLShYYRYEGSLTTPPCYESVLWTVFRDPVTLSKEQLETLEntlmdthnKTLQN--NYRATQPLNGRV 243

                 .
gi 751581042 239 I 239
Cdd:cd03123  244 V 244
alpha_CA_IV_XV_like cd03117
Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are ...
48-241 2.21e-21

Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This subgroup, restricted to animals, contains isozyme IV and similar proteins such as mouse CA XV. Isozymes IV is attached to membranes via a glycosylphosphatidylinositol (GPI) tail. In mammals, Isozyme IV plays crucial roles in kidney and lung function, amongst others. This subgroup also contains the dual domain CA from the giant clam, Tridacna gigas. T. gigas CA plays a role in the movement of inorganic carbon from the surrounding seawater to the symbiotic algae found in the clam's tissues. CA XV is expressed in several species but not in humans or chimps. Similar to isozyme CA IV, CA XV attaches to membranes via a GPI tail.


Pssm-ID: 239391  Cd Length: 234  Bit Score: 88.87  E-value: 2.21e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  48 GKSQSPINIEHYYHTQDK--TDLQFK-YAASKPKAVFFTH-HTLKASFEPTNHINYRG--HDYVLDNVHFH-----AP-M 115
Cdd:cd03117    1 GKRQSPINIVTKKVQYDEnlTPFTFTgYDDTTTNWTITNNgHTVQVTLPDGAKISGGGlpGTYKALQFHFHwgsngSPgS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 116 EFLINNKTRPLSTHFVHKDAKGR-----------LLVLAIGFEEGK-ENPNLDPILEGIQK------KQNFKEVALDAFL 177
Cdd:cd03117   81 EHTIDGERYPMELHIVHIKESYNsllealkdsdgLAVLGFFIEEGEeENTNFDPLISALSNipqkggSTNLTPFSLRSLL 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 751581042 178 PK--SINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQL----------AEIKKRMKNspNQRPVQPDYNTVIIK 241
Cdd:cd03117  161 PSvlLTKYYRYNGSLTTPGCNEAVIWTVFEEPIPISRAQLdafstvlffdTDNGQPMVN--NFRPVQPLNGRVVYA 234
PLN02202 PLN02202
carbonate dehydratase
5-233 6.23e-18

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 80.87  E-value: 6.23e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042   5 FLIALV-LAASLIGAENTKWDYKNKeNGPHRWDKLHKDFEVCKSGKSQSPINIEH----YYHTQDKTDLQFKYAaskpKA 79
Cdd:PLN02202  12 FAIALIcIAPADAQTEGVVFGYKGK-NGPNQWGHLNPHFTKCAVGKLQSPIDIQRrqifYNHKLESIHRDYYFT----NA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  80 VFFTHHTLKASF--EPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSTHFVHKDAKGRLLVLAIGFEEGKENPNLDP 157
Cdd:PLN02202  87 TLVNHVCNVAMFfgEGAGDVIIDNKNYTLLQMHWHTPSEHHLHGVQYAAELHMVHQAKDGSFAVVASLFKIGTEEPFLSQ 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 158 ILEGI--QKKQNFK----------EVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNS 225
Cdd:PLN02202 167 MKDKLvkLKEERFKgnhtaqvevgKIDTRHIERKTRKYFRYIGSLTTPPCSENVSWTILGKVRSMSKEQVELLRSPLDKS 246
                        250
                 ....*....|
gi 751581042 226 --PNQRPVQP 233
Cdd:PLN02202 247 fkNNSRPCQP 256
alpha_CA_IX cd03150
Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
42-243 6.38e-18

Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are strictly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane protein CA IX. CA IX is functionally implicated in tumor growth and survival. CA IX is mainly present in solid tumors and its expression in normal tissues is limited to the mucosa of alimentary tract. CA IX is a transmembrane protein with two extracellular domains: carbonic anhydrase and, a proteoglycan-like segment mediating cell-cell adhesion. There is evidence for an involvement of the MAPK pathway in the regulation of CA9 expression.


Pssm-ID: 239403  Cd Length: 247  Bit Score: 80.00  E-value: 6.38e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  42 FEVCkSGKSQSPINI--EHYYHTQDKTDLQ---FKYAASKPKAVFFTHHTLKASFEPTNHINYR-GHDYVLDNVHFH--- 112
Cdd:cd03150    9 SPAC-AGRFQSPVDIrpHLVAFCPALRPLEllgFDLPPSPSLRLLNNGHTVQLSLPSGLRMALGpGQEYRALQLHLHwga 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 113 --AP-MEFLINNKTRPLSTHFVHKDAK-----------GRLLVLAIGFEEG-KENPNLDPIL---EGIQKKQNFKEVA-- 172
Cdd:cd03150   88 agRPgSEHTVDGHRFPAEIHVVHLSTAfanldealgrpGGLAVLAAFLAEGlHENSAYEQLLsrlSEISEEESETVVPgl 167
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 751581042 173 -LDAFLPKSIN-YYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKN------SPNQRPVQPdYNTVIIKSS 243
Cdd:cd03150  168 dVSALLPSDLSrYFRYEGSLTTPPCAQGVIWTVFNQTVRLSAKQLHTLSDSLWGphdsrlQLNFRATQP-LNGRKIEAS 245
alpha_CA_VII cd03149
Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are ...
104-233 7.31e-18

Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme VII. CA VII is the most active cytosolic enzyme after CA II, and may be highly expressed in the brain. Human CA VII may be a target of antiepileptic sulfonamides/sulfamates.


Pssm-ID: 239402  Cd Length: 236  Bit Score: 79.49  E-value: 7.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 104 YVLDNVHFH------APMEFLINNKTRPLSTHFVHKDAKGR------------LLVLAIGFEEGKENPNLDPILEGIQ-- 163
Cdd:cd03149   64 YRLKQFHFHwgakhgSGSEHTVDGKTFPSELHLVHWNAKKYksfgeaaaapdgLAVLGVFLETGDEHPGLNRLTDALYmv 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 164 ----KKQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSP---------NQRP 230
Cdd:cd03149  144 rfkgTKAQFLDFNPKCLLPKSLDYWTYPGSLTTPPLNESVTWIVLKEPIPVSEKQMGKFRELLFTSEedqrnhmvnNFRP 223

                 ...
gi 751581042 231 VQP 233
Cdd:cd03149  224 PQP 226
alpha_CA_XII_XIV cd03126
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing ...
40-233 2.14e-17

Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane proteins CA XII and XIV.


Pssm-ID: 239400  Cd Length: 249  Bit Score: 78.73  E-value: 2.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  40 KDFEVCkSGKSQSPINIeHYYHTQDKTDLQ------FKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFH- 112
Cdd:cd03126    7 KKYPFC-GGVAQSPIDI-HTDILQYDSSLPplefhgYNVSGTEQFTLTNNGHTVQLSLPPTMHIGGLPFKYTASQLHLHw 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 113 ------APMEFLINNKTRPLSTHFVHKDAKGR------------LLVLAIGFEEGKENPNLDPILEGIQK-KQNFKEVAL 173
Cdd:cd03126   85 gqrgspEGSEHTISGKHFAAELHIVHYNSDKYpdistamnksqgLAVLGILIEVGPFNPSYEKIFSHLHEvKYKDQKVSV 164
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 751581042 174 DAF-----LPKSIN-YYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRM----KNSP-----NQRPVQP 233
Cdd:cd03126  165 PGFnvqelLPKRLDeYYRYEGSLTTPPCYPSVLWTVFRNPVQISQEQLLALETALysteEDESremvnNYRQVQP 239
alpha_CA_V cd03118
Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are ...
48-233 3.40e-15

Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme V. CA V is the mitochondrial isozyme, which may play a role in gluconeogenesis and ureagenesis and possibly also in lipogenesis.


Pssm-ID: 239392  Cd Length: 236  Bit Score: 72.57  E-value: 3.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  48 GKSQSPINIE---HYYHTQDKTdLQFKYAASKPKAVFFTHHTLKASFEPTNHINY-----RGHDYVLDNVHFH------A 113
Cdd:cd03118    1 GTRQSPINIQwrdSVYDPQLAP-LRVSYDPATCLYIWNNGYSFQVEFDDSTDKSGisggpLENHYRLKQFHFHwganneW 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 114 PMEFLINNKTRPLSTHFVHKDA------------KGRLLVLAIGFEEGKENPNLDP---ILEGIQKKQNfkEVALDAF-- 176
Cdd:cd03118   80 GSEHTVDGHTYPAELHLVHWNSvkyenfeeavmeENGLAVIGVFLKLGAHHEGLQKlvdALPEVRHKDT--VVEFNPFdp 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 751581042 177 ---LPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLA-----------EIKKRMKNspNQRPVQP 233
Cdd:cd03118  158 sclLPACRDYWTYPGSLTTPPLTESVTWIIQKQPIEVSPSQLSvfrtllftsrgEEEKVMVN--NFRPLQP 226
alpha_CARP_VIII cd03120
Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins ...
47-239 9.66e-15

Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP VIII may play roles in various biological processes of the central nervous system, and could be involved in protein-protein interactions. CARP VIII has been shown to bind inositol 1,4,5-triphosphate (IP3) receptor type I (IP3RI), reducing the affinity of the receptor for IP3. IP3RI is an intracellular IP3-gated Ca2+ channel located on intracellular Ca2+ stores. IP3RI converts IP3 signaling into Ca2+ signaling thereby participating in a variety of cell functions.


Pssm-ID: 239394  Cd Length: 256  Bit Score: 71.43  E-value: 9.66e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  47 SGKSQSPINIEHYYHTQDKTDLQFK----YAASKPKAVFFTHHTLKASFEPTNHIN----YRGHDYVLDNVHFH------ 112
Cdd:cd03120   12 NGEYQSPINLNSREARYDPSLLEVRlspnYVVCRDCEVINDGHTIQIILKSKSVLSggplPQGHEFELAEVRFHwgrenq 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 113 APMEFLINNKTRPLSTHFVH---------KDAKGR---LLVLAIGFEEGKENPNLDPI---LEGIQKKQnfKEVALDAFL 177
Cdd:cd03120   92 RGSEHTVNFKAFPMELHLIHwnstlysslEEAMGKphgIAIIALFVQIGKEHVGLKAVteiLQDIQYKG--KSKTIPCFN 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 178 PKSI-------NYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIkKRMKN---------------SPNQRPVQPDY 235
Cdd:cd03120  170 PNTLlpdpllrDYWVYEGSLTTPPCSEGVTWILFRYPLTISQSQIEEF-RRLRThvkgaelvegcdgllGDNFRPTQPLS 248

                 ....
gi 751581042 236 NTVI 239
Cdd:cd03120  249 DRVI 252
alpha_CARP_X_XI_like cd03121
Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup ...
31-239 1.87e-14

Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP XI plays a role in the development of gastrointestinal stromal tumors.


Pssm-ID: 239395 [Multi-domain]  Cd Length: 256  Bit Score: 70.52  E-value: 1.87e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  31 GPHRWDKLHKDFEVCKSGKSQSPINIEhyyhtqdkTDlQFKYAASKPKAVFFTHHTLKASFEPT-----------NHINY 99
Cdd:cd03121    1 GPSFWGLVNSAWNLCSKGRRQSPVDIE--------PS-RLLFDPFLTPLRIDTGRKVSGTFYNTgrhvsfrpdkdPVVNI 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 100 RG----HDYVLDNVHFH------APMEFLINNKTRPLSTHFVH-------------KDAKGrLLVLAIGFEEGKE-NPNL 155
Cdd:cd03121   72 SGgplsYRYRLEEIRLHfgredeQGSEHTVNGQAFPGEVQLIHynselypnfseasKSPNG-LVIVSLFVKIGETsNPEL 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 156 DPILEGIQKKQ-NFKEVA-------LDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSP- 226
Cdd:cd03121  151 RRLTNRDTITSiRYKGDAyflqdlsIELLLPETDHYITYEGSLTSPGCHETVTWIILNKPIYITKEQMHSLRLLSQNSPs 230
                        250       260
                 ....*....|....*....|.
gi 751581042 227 --------NQRPVQPDYNTVI 239
Cdd:cd03121  231 qekapmspNFRPVQPLNNRPV 251
alpha_CA_VI cd03125
Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
48-239 9.94e-13

Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva.


Pssm-ID: 239399  Cd Length: 249  Bit Score: 65.58  E-value: 9.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042  48 GKSQSPINIEHYYHTQDKTDLQFKYAASKPKAVFFTH----HTLKASFEPTNHINYR-GHDYVLDNVHFH--------AP 114
Cdd:cd03125   14 GKRQSPIDIQRREVRFNPSLLQLELVGYEKEQGEFTMtnngHTVQIDLPPTMSITTGdGTVYTAVQMHFHwggrdseiSG 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751581042 115 MEFLINNKTRPLSTHFVH-----------KDAKGRLLVLAIGFEEGK--ENPNLDPILEGIQK------KQNFKEVALDA 175
Cdd:cd03125   94 SEHTIDGMRYVAELHIVHynskyksyeeaKDKPDGLAVLAFLYKVGHyaENTYYSDFISKLAKikyagqTTTLTSLDVRD 173
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 751581042 176 FLPKSI-NYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQ------RPVQPDYNTVI 239
Cdd:cd03125  174 MLPENLhHYYTYQGSLTTPPCTENVLWFVFDDPVTLSKTQIVKLENTLMDHHNKtirndyRRTQPLNHRVV 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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