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Conserved domains on  [gi|752540636|ref|WP_041212083|]
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alpha/beta fold hydrolase [Aeromonas caviae]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 229394)

alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Abhydrolase super family cl21494
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ...
 27-346 4.26e-110

alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom.


The actual alignment was detected with superfamily member PRK10749:

Pssm-ID: 473884  Cd Length: 330  Bit Score: 323.87  E-value: 4.26e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636  27 LTTEADVPALYQQTLPDFWRDHAApGEFKGKDGVTLRYAALRQPKIDRAILIVNGRVESYLKYQELAWDLWRQGYSLYLI 106
Cdd:PRK10749   9 LTRENAFAAFTMGPLLDFWRQREE-AEFTGVDDIPIRFVRFRAPHHDRVVVICPGRIESYVKYAELAYDLFHLGYDVLII 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 107 DHRGQGMSDRMLADKEKGYVDQFDDYVADLKQFHDEVIAQDQPAKLFLLAHSMGGAISARYLERWPNDIQAAVLSSPMMG 186
Cdd:PRK10749  88 DHRGQGRSGRLLDDPHRGHVERFNDYVDDLAAFWQQEIQPGPYRKRYALAHSMGGAILTLFLQRHPGVFDAIALCAPMFG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 187 INLgGLPKWLAKGLAAtigtvggWVGEPP-----YGPGQGPYEDHGFADNELTHSTARYQAFRQIYEQHPQVRLGGATAH 261
Cdd:PRK10749 168 IVL-PLPSWMARRILN-------WAEGHPrirdgYAIGTGRWRPLPFAINVLTHSRERYRRNLRFYADDPELRVGGPTYH 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 262 WIHQAITGSDAAVADAGAIKTPLLLLQAGEDSVVDNAAQEAFC-----AKAQCEGGKPLRIDGAWHELFIEADPQRQAAL 336
Cdd:PRK10749 240 WVRESILAGEQVLAGAGDITTPLLLLQAEEERVVDNRMHDRFCeartaAGHPCEGGKPLVIKGAYHEILFEKDAMRSVAL 319

                        330
                 ....*....|
gi 752540636 337 NATLAFFARY 346
Cdd:PRK10749 320 NAIVDFFNRH 329
 
Name Accession Description Interval E-value
PRK10749 PRK10749
lysophospholipase L2; Provisional
 27-346 4.26e-110

lysophospholipase L2; Provisional


Pssm-ID: 182697  Cd Length: 330  Bit Score: 323.87  E-value: 4.26e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636  27 LTTEADVPALYQQTLPDFWRDHAApGEFKGKDGVTLRYAALRQPKIDRAILIVNGRVESYLKYQELAWDLWRQGYSLYLI 106
Cdd:PRK10749   9 LTRENAFAAFTMGPLLDFWRQREE-AEFTGVDDIPIRFVRFRAPHHDRVVVICPGRIESYVKYAELAYDLFHLGYDVLII 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 107 DHRGQGMSDRMLADKEKGYVDQFDDYVADLKQFHDEVIAQDQPAKLFLLAHSMGGAISARYLERWPNDIQAAVLSSPMMG 186
Cdd:PRK10749  88 DHRGQGRSGRLLDDPHRGHVERFNDYVDDLAAFWQQEIQPGPYRKRYALAHSMGGAILTLFLQRHPGVFDAIALCAPMFG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 187 INLgGLPKWLAKGLAAtigtvggWVGEPP-----YGPGQGPYEDHGFADNELTHSTARYQAFRQIYEQHPQVRLGGATAH 261
Cdd:PRK10749 168 IVL-PLPSWMARRILN-------WAEGHPrirdgYAIGTGRWRPLPFAINVLTHSRERYRRNLRFYADDPELRVGGPTYH 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 262 WIHQAITGSDAAVADAGAIKTPLLLLQAGEDSVVDNAAQEAFC-----AKAQCEGGKPLRIDGAWHELFIEADPQRQAAL 336
Cdd:PRK10749 240 WVRESILAGEQVLAGAGDITTPLLLLQAEEERVVDNRMHDRFCeartaAGHPCEGGKPLVIKGAYHEILFEKDAMRSVAL 319

                        330
                 ....*....|
gi 752540636 337 NATLAFFARY 346
Cdd:PRK10749 320 NAIVDFFNRH 329
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 70-329 8.97e-68

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 212.84  E-value: 8.97e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636   70 PKIDRAILIVNGRVESYLKYQELAWDLWRQGYSLYLIDHRGQGMSDRmladkEKGYVDQFDDYVADLKQFHDEVIAQDQP 149
Cdd:pfam12146   1 GEPRAVVVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHGRSDG-----KRGHVPSFDDYVDDLDTFVDKIREEHPG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636  150 AKLFLLAHSMGGAISARYLERWPNDIQAAVLSSPMMGINLGGLPKWLaKGLAATIGTVggwvgeppygpgqgpYEDHGFA 229
Cdd:pfam12146  76 LPLFLLGHSMGGLIAALYALRYPDKVDGLILSAPALKIKPYLAPPIL-KLLAKLLGKL---------------FPRLRVP 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636  230 DNELTHSTARYQAFRQIYEQHPQVRlGGATAHWIHQAITGSDAAVADAGAIKTPLLLLQAGEDSVVDNAAQEAFCAKAQC 309
Cdd:pfam12146 140 NNLLPDSLSRDPEVVAAYAADPLVH-GGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGS 218

                         250       260
                  ....*....|....*....|
gi 752540636  310 EGGKPLRIDGAWHELFIEAD 329
Cdd:pfam12146 219 TDKTLKLYPGLYHELLNEPD 238
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
51-345 2.22e-43

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 149.38  E-value: 2.22e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636  51 PGEFKGKDGVTLRYAALR-QPKIDRAILIVNGRVESYLKYQELAWDLWRQGYSLYLIDHRGQGMSDRmladkEKGYVDQF 129
Cdd:COG2267    5 LVTLPTRDGLRLRGRRWRpAGSPRGTVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRSDG-----PRGHVDSF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 130 DDYVADLKQFHDEvIAQDQPAKLFLLAHSMGGAISARYLERWPNDIQAAVLSSPMmginlgglpkwlakglaatigtvgg 209
Cdd:COG2267   80 DDYVDDLRAALDA-LRARPGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPA------------------------- 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 210 wvgeppygpgqgpyedhgfadnelthstaryqafrqiYEQHPqvrLGGATAHWIHQAitgsdAAVADAGAIKTPLLLLQA 289
Cdd:COG2267  134 -------------------------------------YRADP---LLGPSARWLRAL-----RLAEALARIDVPVLVLHG 168

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 752540636 290 GEDSVVDNAAQEAFCAKAqCEGGKPLRIDGAWHELFIEADpqRQAALNATLAFFAR 345
Cdd:COG2267  169 GADRVVPPEAARRLAARL-SPDVELVLLPGARHELLNEPA--REEVLAAILAWLER 221
PST-A TIGR01607
Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in ...
 73-169 1.50e-07

Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in Plasmodium falciparum and Plasmodium yoelii, which are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii.


Pssm-ID: 162444 [Multi-domain]  Cd Length: 332  Bit Score: 52.48  E-value: 1.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636   73 DRAILIvngRVESYLKYQElAW--DLWRQGYSLYLIDHRGQGMSDRMlaDKEKGYVDQFDDYVADLKQF----------- 139
Cdd:TIGR01607  49 DRAVLI---DTDNYYIYKD-SWieNFNKNGYSVYGLDLQGHGESDGL--QNLRGHINCFDDLVYDVIQYmnrindsiile 122

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 752540636  140 ---------HDEVIAQDQPAKLFLLAHSMGGAISARYLE 169
Cdd:TIGR01607 123 netksddesYDIVNTKENRLPMYIIGLSMGGNIALRLLE 161
 
Name Accession Description Interval E-value
PRK10749 PRK10749
lysophospholipase L2; Provisional
 27-346 4.26e-110

lysophospholipase L2; Provisional


Pssm-ID: 182697  Cd Length: 330  Bit Score: 323.87  E-value: 4.26e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636  27 LTTEADVPALYQQTLPDFWRDHAApGEFKGKDGVTLRYAALRQPKIDRAILIVNGRVESYLKYQELAWDLWRQGYSLYLI 106
Cdd:PRK10749   9 LTRENAFAAFTMGPLLDFWRQREE-AEFTGVDDIPIRFVRFRAPHHDRVVVICPGRIESYVKYAELAYDLFHLGYDVLII 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 107 DHRGQGMSDRMLADKEKGYVDQFDDYVADLKQFHDEVIAQDQPAKLFLLAHSMGGAISARYLERWPNDIQAAVLSSPMMG 186
Cdd:PRK10749  88 DHRGQGRSGRLLDDPHRGHVERFNDYVDDLAAFWQQEIQPGPYRKRYALAHSMGGAILTLFLQRHPGVFDAIALCAPMFG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 187 INLgGLPKWLAKGLAAtigtvggWVGEPP-----YGPGQGPYEDHGFADNELTHSTARYQAFRQIYEQHPQVRLGGATAH 261
Cdd:PRK10749 168 IVL-PLPSWMARRILN-------WAEGHPrirdgYAIGTGRWRPLPFAINVLTHSRERYRRNLRFYADDPELRVGGPTYH 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 262 WIHQAITGSDAAVADAGAIKTPLLLLQAGEDSVVDNAAQEAFC-----AKAQCEGGKPLRIDGAWHELFIEADPQRQAAL 336
Cdd:PRK10749 240 WVRESILAGEQVLAGAGDITTPLLLLQAEEERVVDNRMHDRFCeartaAGHPCEGGKPLVIKGAYHEILFEKDAMRSVAL 319

                        330
                 ....*....|
gi 752540636 337 NATLAFFARY 346
Cdd:PRK10749 320 NAIVDFFNRH 329
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 70-329 8.97e-68

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 212.84  E-value: 8.97e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636   70 PKIDRAILIVNGRVESYLKYQELAWDLWRQGYSLYLIDHRGQGMSDRmladkEKGYVDQFDDYVADLKQFHDEVIAQDQP 149
Cdd:pfam12146   1 GEPRAVVVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHGRSDG-----KRGHVPSFDDYVDDLDTFVDKIREEHPG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636  150 AKLFLLAHSMGGAISARYLERWPNDIQAAVLSSPMMGINLGGLPKWLaKGLAATIGTVggwvgeppygpgqgpYEDHGFA 229
Cdd:pfam12146  76 LPLFLLGHSMGGLIAALYALRYPDKVDGLILSAPALKIKPYLAPPIL-KLLAKLLGKL---------------FPRLRVP 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636  230 DNELTHSTARYQAFRQIYEQHPQVRlGGATAHWIHQAITGSDAAVADAGAIKTPLLLLQAGEDSVVDNAAQEAFCAKAQC 309
Cdd:pfam12146 140 NNLLPDSLSRDPEVVAAYAADPLVH-GGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGS 218

                         250       260
                  ....*....|....*....|
gi 752540636  310 EGGKPLRIDGAWHELFIEAD 329
Cdd:pfam12146 219 TDKTLKLYPGLYHELLNEPD 238
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
51-345 2.22e-43

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 149.38  E-value: 2.22e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636  51 PGEFKGKDGVTLRYAALR-QPKIDRAILIVNGRVESYLKYQELAWDLWRQGYSLYLIDHRGQGMSDRmladkEKGYVDQF 129
Cdd:COG2267    5 LVTLPTRDGLRLRGRRWRpAGSPRGTVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRSDG-----PRGHVDSF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 130 DDYVADLKQFHDEvIAQDQPAKLFLLAHSMGGAISARYLERWPNDIQAAVLSSPMmginlgglpkwlakglaatigtvgg 209
Cdd:COG2267   80 DDYVDDLRAALDA-LRARPGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPA------------------------- 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 210 wvgeppygpgqgpyedhgfadnelthstaryqafrqiYEQHPqvrLGGATAHWIHQAitgsdAAVADAGAIKTPLLLLQA 289
Cdd:COG2267  134 -------------------------------------YRADP---LLGPSARWLRAL-----RLAEALARIDVPVLVLHG 168

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 752540636 290 GEDSVVDNAAQEAFCAKAqCEGGKPLRIDGAWHELFIEADpqRQAALNATLAFFAR 345
Cdd:COG2267  169 GADRVVPPEAARRLAARL-SPDVELVLLPGARHELLNEPA--REEVLAAILAWLER 221
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 75-329 3.53e-18

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 82.55  E-value: 3.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636   75 AILIVNGRVESYLKYQELAWDLWRQGYSLYLIDHRGQGMSDRMLADKEkgYvdQFDDYVADLKQFHDEVIAQdqpaKLFL 154
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGKSSRPKAQDD--Y--RTDDLAEDLEYILEALGLE----KVNL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636  155 LAHSMGGAISARYLERWPNDIQAAVLSSPMMgiNLGGLPKWL---AKGLAATIGTVGGWVGEPPYGPGQGPYEDHGFADN 231
Cdd:pfam00561  74 VGHSMGGLIALAYAAKYPDRVKALVLLGALD--PPHELDEADrfiLALFPGFFDGFVADFAPNPLGRLVAKLLALLLLRL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636  232 ELTHSTARYqaFRQIYEQHPQVRLGGATAHWIHQAITGSDAAVADAGAIKTPLLLLQAGEDSVVDNAAQEAFCAKaqCEG 311
Cdd:pfam00561 152 RLLKALPLL--NKRFPSGDYALAKSLVTGALLFIETWSTELRAKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQL--FPN 227

                         250
                  ....*....|....*...
gi 752540636  312 GKPLRIDGAWHELFIEAD 329
Cdd:pfam00561 228 ARLVVIPDAGHFAFLEGP 245
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
53-346 1.07e-14

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 72.36  E-value: 1.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636  53 EFKGKDGVTLrYAALRQPKIDR---AILIVNGRVES-YLKYQELAWDLWRQGYSLYLIDHRGQGMSDRMLADKEkgyvdq 128
Cdd:COG1506    1 TFKSADGTTL-PGWLYLPADGKkypVVVYVHGGPGSrDDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGDE------ 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 129 fddyVADLKQFHDEVIAQDQ--PAKLFLLAHSMGGAISARYLERWPNDIQAAVLSSpmmginlgglpkwlakglaatigt 206
Cdd:COG1506   74 ----VDDVLAAIDYLAARPYvdPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALA------------------------ 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 207 vggwvgeppygpgqgpyedhGFADneLTHSTARYQAFRQIYEQHPQVRLGGATAHwihqaitgsdAAVADAGAIKTPLLL 286
Cdd:COG1506  126 --------------------GVSD--LRSYYGTTREYTERLMGGPWEDPEAYAAR----------SPLAYADKLKTPLLL 173

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 752540636 287 LQAGEDSVVDNAAQEAFCAKAQcEGGKP---LRIDGAWHELFIEADPQRqaaLNATLAFFARY 346
Cdd:COG1506  174 IHGEADDRVPPEQAERLYEALK-KAGKPvelLVYPGEGHGFSGAGAPDY---LERILDFLDRH 232
PHA02857 PHA02857
monoglyceride lipase; Provisional
 76-337 2.15e-12

monoglyceride lipase; Provisional


Pssm-ID: 165193 [Multi-domain]  Cd Length: 276  Bit Score: 66.45  E-value: 2.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636  76 ILIVNGRVESYLKYQELAWDLWRQGYSLYLIDHRGQGMSDrmladKEKGYVDQFDDYVADLKQfHDEVIAQDQP-AKLFL 154
Cdd:PHA02857  28 VFISHGAGEHSGRYEELAENISSLGILVFSHDHIGHGRSN-----GEKMMIDDFGVYVRDVVQ-HVVTIKSTYPgVPVFL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 155 LAHSMGGAISARYLERWPNDIQAAVLSSPMmgINLGGLPKWlakGLAATigtvggwvgeppygpgqgpYEDHGFADNELT 234
Cdd:PHA02857 102 LGHSMGATISILAAYKNPNLFTAMILMSPL--VNAEAVPRL---NLLAA-------------------KLMGIFYPNKIV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 235 H-----STARYQAFRQIYEQHPQVRLGGATAHWIHQAITGSDAAVADAGAIKTPLLLLQAGEDSVVDNAAQEAFCAKAQC 309
Cdd:PHA02857 158 GklcpeSVSRDMDEVYKYQYDPLVNHEKIKAGFASQVLKATNKVRKIIPKIKTPILILQGTNNEISDVSGAYYFMQHANC 237

                        250       260
                 ....*....|....*....|....*....
gi 752540636 310 EggKPLRI-DGAWHELFIEADPQRQAALN 337
Cdd:PHA02857 238 N--REIKIyEGAKHHLHKETDEVKKSVMK 264
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
90-346 4.06e-11

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 62.27  E-value: 4.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636  90 QELAWDLWRQGYSLYLIDHRGQGMSDRMLAD-KEKGYVDQFDDYVADLKQFHDEViaqdqpaklFLLAHSMGGAISARYL 168
Cdd:COG1647   32 RPLAEALAKAGYTVYAPRLPGHGTSPEDLLKtTWEDWLEDVEEAYEILKAGYDKV---------IVIGLSMGGLLALLLA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 169 ERWPnDIQAAVLSSPMMGINlgglpkwlakGLAATIGTVGGWVGEPPYGPGQgpyedhgfadnelthSTARYQAFRQIYE 248
Cdd:COG1647  103 ARYP-DVAGLVLLSPALKID----------DPSAPLLPLLKYLARSLRGIGS---------------DIEDPEVAEYAYD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 249 QHPQVRLggatahwiHQAITGSDAAVADAGAIKTPLLLLQAGEDSVVDNAAQEAFCAKAQCEGGKPLRIDGAWHelFIEA 328
Cdd:COG1647  157 RTPLRAL--------AELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGH--VITL 226

                        250
                 ....*....|....*...
gi 752540636 329 DPQRQAALNATLAFFARY 346
Cdd:COG1647  227 DKDREEVAEEILDFLERL 244
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 95-345 1.52e-10

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 60.40  E-value: 1.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636  95 DLWRQGYSLYLIDHRGQGMSDRMLADkekgyvDQFDDYVADLKQFHDEVIAQdqpaKLFLLAHSMGGAISARYLERWPND 174
Cdd:COG0596   44 PALAAGYRVIAPDLRGHGRSDKPAGG------YTLDDLADDLAALLDALGLE----RVVLVGHSMGGMVALELAARHPER 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 175 IQAAVLsspmmginLGGLPKWLAKGLAAtigtvggwvgeppygPGQGPyedhgfadnelthstaryQAFRQIYEqhpqvr 254
Cdd:COG0596  114 VAGLVL--------VDEVLAALAEPLRR---------------PGLAP------------------EALAALLR------ 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 255 lggatahwihqAITGSDAAvADAGAIKTPLLLLQAGEDSVVDNAAQEAFcaKAQCEGGKPLRIDGAWHELFIEadpQRQA 334
Cdd:COG0596  147 -----------ALARTDLR-ERLARITVPTLVIWGEKDPIVPPALARRL--AELLPNAELVVLPGAGHFPPLE---QPEA 209

                        250
                 ....*....|.
gi 752540636 335 ALNATLAFFAR 345
Cdd:COG0596  210 FAAALRDFLAR 220
PLN02298 PLN02298
hydrolase, alpha/beta fold family protein
 89-329 7.06e-09

hydrolase, alpha/beta fold family protein


Pssm-ID: 165939 [Multi-domain]  Cd Length: 330  Bit Score: 56.32  E-value: 7.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636  89 YQELAWDLWRQGYSLYLIDHRGQGMSDRMladkeKGYVDQFDDYVADLKQFHDEVIAQDQPAKL--FLLAHSMGGAISAR 166
Cdd:PLN02298  76 FQSTAIFLAQMGFACFALDLEGHGRSEGL-----RAYVPNVDLVVEDCLSFFNSVKQREEFQGLprFLYGESMGGAICLL 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 167 -YLERwPNDIQAAVLSSPMMGINLGGLPKW--------LAKgLAATIGTVggwvgeppygpgqgPYEDhgfadneLTHST 237
Cdd:PLN02298 151 iHLAN-PEGFDGAVLVAPMCKISDKIRPPWpipqiltfVAR-FLPTLAIV--------------PTAD-------LLEKS 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 238 ARYQAFRQIYEQHP-----QVRLGGatahwIHQAITGSDAAVADAGAIKTPLLLLQAGEDSVVDNAAQEAFCAKAQCEgG 312
Cdd:PLN02298 208 VKVPAKKIIAKRNPmryngKPRLGT-----VVELLRVTDYLGKKLKDVSIPFIVLHGSADVVTDPDVSRALYEEAKSE-D 281

                        250
                 ....*....|....*....
gi 752540636 313 KPLRI-DGAWHE-LFIEAD 329
Cdd:PLN02298 282 KTIKIyDGMMHSlLFGEPD 300
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
 100-330 3.93e-08

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 54.37  E-value: 3.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 100 GYSLYLIDHRGQGMSDRMladkeKGYVDQFDDYVADLKQFHDEVIAQDQPAKL--FLLAHSMGGAISARYLERWPNDIQA 177
Cdd:PLN02385 115 GYGVFAMDYPGFGLSEGL-----HGYIPSFDDLVDDVIEHYSKIKGNPEFRGLpsFLFGQSMGGAVALKVHLKQPNAWDG 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 178 AVLSSPMMGINLGGLPKWLAKGLAATIGTVggwVGEPPYGPgQGPYEDHGFADNelthSTARYQAFRQI-YEQHPQVRlg 256
Cdd:PLN02385 190 AILVAPMCKIADDVVPPPLVLQILILLANL---LPKAKLVP-QKDLAELAFRDL----KKRKMAEYNVIaYKDKPRLR-- 259

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 752540636 257 gaTAHWIHQAITGSDAAVADagaIKTPLLLLQAGEDSVVDNAAQEAFCAKAQCEGGKPLRIDGAWHELfIEADP 330
Cdd:PLN02385 260 --TAVELLRTTQEIEMQLEE---VSLPLLILHGEADKVTDPSVSKFLYEKASSSDKKLKLYEDAYHSI-LEGEP 327
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 53-184 9.42e-08

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 52.22  E-value: 9.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636  53 EFKGKDGVTLR---YAALRQPKIDRAILIV--NGRV-ESYLKYqelAWDLWRQGYSLYLIDHRGQGMSDrmladkekGYV 126
Cdd:COG1073   14 TFKSRDGIKLAgdlYLPAGASKKYPAVVVAhgNGGVkEQRALY---AQRLAELGFNVLAFDYRGYGESE--------GEP 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 752540636 127 DQFDDYVA-DLKQFHDEVIAQDQ--PAKLFLLAHSMGGAISARYLERWPNdIQAAVLSSPM 184
Cdd:COG1073   83 REEGSPERrDARAAVDYLRTLPGvdPERIGLLGISLGGGYALNAAATDPR-VKAVILDSPF 142
PST-A TIGR01607
Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in ...
 73-169 1.50e-07

Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in Plasmodium falciparum and Plasmodium yoelii, which are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii.


Pssm-ID: 162444 [Multi-domain]  Cd Length: 332  Bit Score: 52.48  E-value: 1.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636   73 DRAILIvngRVESYLKYQElAW--DLWRQGYSLYLIDHRGQGMSDRMlaDKEKGYVDQFDDYVADLKQF----------- 139
Cdd:TIGR01607  49 DRAVLI---DTDNYYIYKD-SWieNFNKNGYSVYGLDLQGHGESDGL--QNLRGHINCFDDLVYDVIQYmnrindsiile 122

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 752540636  140 ---------HDEVIAQDQPAKLFLLAHSMGGAISARYLE 169
Cdd:TIGR01607 123 netksddesYDIVNTKENRLPMYIIGLSMGGNIALRLLE 161
PLN02652 PLN02652
hydrolase; alpha/beta fold family protein
 74-185 6.22e-06

hydrolase; alpha/beta fold family protein


Pssm-ID: 215352 [Multi-domain]  Cd Length: 395  Bit Score: 47.58  E-value: 6.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636  74 RAIL-IVNGRVESYLKYQELAWDLWRQGYSLYLIDHRGQGMSDRMladkeKGYVDQFDDYVADLKQFHDEVIAQDQPAKL 152
Cdd:PLN02652 136 RGILiIIHGLNEHSGRYLHFAKQLTSCGFGVYAMDWIGHGGSDGL-----HGYVPSLDYVVEDTEAFLEKIRSENPGVPC 210

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 752540636 153 FLLAHSMGGAI--SARYLERWPNDIQAAVLSSPMM 185
Cdd:PLN02652 211 FLFGHSTGGAVvlKAASYPSIEDKLEGIVLTSPAL 245
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 64-183 6.42e-05

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 41.74  E-value: 6.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636  64 YAALRQPkidraILIVNGRVESYLKYQELAWDLWRQGYSLYLIDHRGQGMSdrmladkekgyvdqFDDYVADLKQFHDEV 143
Cdd:COG1075    1 YAATRYP-----VVLVHGLGGSAASWAPLAPRLRAAGYPVYALNYPSTNGS--------------IEDSAEQLAAFVDAV 61

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 752540636 144 IAQDQPAKLFLLAHSMGGAISARYLERW--PNDIQAAV-LSSP 183
Cdd:COG1075   62 LAATGAEKVDLVGHSMGGLVARYYLKRLggAAKVARVVtLGTP 104
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 76-251 1.10e-04

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 42.85  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636   76 ILIVNGrveSYLKYQELAwDLWRQGYSLYLIDHRGQGMSDRMLADkekgyvdqFDDyVADLKQFHDEVIAQDQPaklFLL 155
Cdd:pfam12697   1 VVLVHG---AGLSAAPLA-ALLAAGVAVLAPDLPGHGSSSPPPLD--------LAD-LADLAALLDELGAARPV---VLV 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636  156 AHSMGGAISARYLERwpnDIQAAVLSSPMMGINLGGLPKWLAKGLAATIGTVGGWVGEPPYGPGQGPYEDHGFADNELTH 235
Cdd:pfam12697  65 GHSLGGAVALAAAAA---ALVVGVLVAPLAAPPGLLAALLALLARLGAALAAPAWLAAESLARGFLDDLPADAEWAAALA 141

                         170
                  ....*....|....*.
gi 752540636  236 STARYQAFRQIYEQHP 251
Cdd:pfam12697 142 RLAALLAALALLPLAA 157
YpfH COG0400
Predicted esterase [General function prediction only];
127-185 6.15e-03

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 37.58  E-value: 6.15e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 752540636 127 DQFDDYVADLKQFHDEVIAQDQ--PAKLFLLAHSMGGAISARYLERWPNDIQAAVLSSPMM 185
Cdd:COG0400   64 EGLAAAAEALAAFIDELEARYGidPERIVLAGFSQGAAMALSLALRRPELLAGVVALSGYL 124
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
271-344 8.62e-03

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 37.25  E-value: 8.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752540636 271 DAAVADAGAIKTPLLLLQAGEDSVVDNAAQEAFcAKAQCEGGKPLRI---DGAWHELFIEADPQ-----RQAALNATLAF 342
Cdd:COG0412  146 DDLLDLAARIKAPVLLLYGEKDPLVPPEQVAAL-EAALAAAGVDVELhvyPGAGHGFTNPGRPRydpaaAEDAWQRTLAF 224


                 ..
gi 752540636 343 FA 344
Cdd:COG0412  225 LA 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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