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Conserved domains on  [gi|752540763|ref|WP_041212210|]
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MULTISPECIES: type II secretion system protein [Aeromonas]

Protein Classification

type II secretion system protein( domain architecture ID 11450365)

type II secretion system protein similar to Pseudomonas aeruginosa type II secretion system protein H, which is involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins; required for the translocation of a variety of enzymes across the outer membrane; pilin similar to fimbrial protein PilE, which is required for pilus biogenesis, as well as fimbrial protein PilA, which is responsible for the adhesive property of the pilus

Gene Ontology:  GO:0005886|GO:0015628|GO:0015627
PubMed:  30767847|1365398

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 7-54 6.62e-11

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


:

Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 57.23  E-value: 6.62e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 752540763   7 RPVRALGRMAGFSLIELVIVIVILGILAVTALPRFLDVTDEAKKASVE 54
Cdd:COG2165    2 KLRRRRRRQRGFTLIELLVVIAIIGILAALALPALQGARERARRAELR 49
 
Name Accession Description Interval E-value
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 7-54 6.62e-11

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 57.23  E-value: 6.62e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 752540763   7 RPVRALGRMAGFSLIELVIVIVILGILAVTALPRFLDVTDEAKKASVE 54
Cdd:COG2165    2 KLRRRRRRQRGFTLIELLVVIAIIGILAALALPALQGARERARRAELR 49
typeII_sec_gspG TIGR01710
type II secretion system protein G; This model represents GspG, protein G of the main terminal ...
 17-58 1.05e-05

type II secretion system protein G; This model represents GspG, protein G of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 130771 [Multi-domain]  Cd Length: 134  Bit Score: 43.57  E-value: 1.05e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 752540763   17 GFSLIELVIVIVILGILAVTALPRFLDVTDEAK----KASVEGVSG 58
Cdd:TIGR01710   2 GFTLLEIMVVLVILGLLAALVAPKLFSQADKAKaqvaKAQIKALKN 47
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 14-38 1.21e-05

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 40.82  E-value: 1.21e-05
                          10        20
                  ....*....|....*....|....*
gi 752540763   14 RMAGFSLIELVIVIVILGILAVTAL 38
Cdd:pfam07963   3 KQRGFTLIELLVALAILAILLAAAL 27
PRK10574 PRK10574
putative major pilin subunit; Provisional
 17-39 6.71e-03

putative major pilin subunit; Provisional


Pssm-ID: 236718 [Multi-domain]  Cd Length: 146  Bit Score: 35.78  E-value: 6.71e-03
                         10        20
                 ....*....|....*....|...
gi 752540763  17 GFSLIELVIVIVILGILAVTALP 39
Cdd:PRK10574   6 GFTLIELMVVIAIIAILSAIGIP 28
 
Name Accession Description Interval E-value
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 7-54 6.62e-11

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 57.23  E-value: 6.62e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 752540763   7 RPVRALGRMAGFSLIELVIVIVILGILAVTALPRFLDVTDEAKKASVE 54
Cdd:COG2165    2 KLRRRRRRQRGFTLIELLVVIAIIGILAALALPALQGARERARRAELR 49
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
14-70 2.12e-09

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 52.16  E-value: 2.12e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 752540763  14 RMAGFSLIELVIVIVILGILAVTALPRFLDVTDEAKkasVEGVSGGFATGVSLVRAQ 70
Cdd:COG4970    7 RQRGFTLIELLVVLAILAILAAIAVPSFSSLIARQR---LRAAANELAAALRLARSE 60
PilE COG4968
Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];
14-49 5.49e-09

Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];


Pssm-ID: 443994 [Multi-domain]  Cd Length: 124  Bit Score: 52.38  E-value: 5.49e-09
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 752540763  14 RMAGFSLIELVIVIVILGILAVTALPRFLDVTDEAK 49
Cdd:COG4968    8 RQRGFTLIELMIVVAIIGILAAIAIPSYQDYVERAR 43
PilA COG4969
Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];
17-66 5.73e-09

Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];


Pssm-ID: 443995 [Multi-domain]  Cd Length: 134  Bit Score: 52.79  E-value: 5.73e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 752540763  17 GFSLIELVIVIVILGILAVTALPRFLDVTDEAKKASVEGVSGGFATGVSL 66
Cdd:COG4969    7 GFTLIELMIVVAIIGILAAIAIPAYQDYVARARVSEALALASPLKTAVEE 56
ComGC COG4537
Competence protein ComGC [Mobilome: prophages, transposons];
17-73 8.58e-09

Competence protein ComGC [Mobilome: prophages, transposons];


Pssm-ID: 443603 [Multi-domain]  Cd Length: 108  Bit Score: 51.47  E-value: 8.58e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 752540763  17 GFSLIELVIVIVILGILAVTALPRFLDVTDEAKKASVEGVsggfatgVSLVRAQWEA 73
Cdd:COG4537   13 GFTLIEMLIVLLIISILLLIAVPNLTKQRETAQEKGCEAN-------IKMVQSQVEL 62
typeII_sec_gspG TIGR01710
type II secretion system protein G; This model represents GspG, protein G of the main terminal ...
 17-58 1.05e-05

type II secretion system protein G; This model represents GspG, protein G of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 130771 [Multi-domain]  Cd Length: 134  Bit Score: 43.57  E-value: 1.05e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 752540763   17 GFSLIELVIVIVILGILAVTALPRFLDVTDEAK----KASVEGVSG 58
Cdd:TIGR01710   2 GFTLLEIMVVLVILGLLAALVAPKLFSQADKAKaqvaKAQIKALKN 47
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 14-38 1.21e-05

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 40.82  E-value: 1.21e-05
                          10        20
                  ....*....|....*....|....*
gi 752540763   14 RMAGFSLIELVIVIVILGILAVTAL 38
Cdd:pfam07963   3 KQRGFTLIELLVALAILAILLAAAL 27
IV_pilin_GFxxxE TIGR02532
prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all ...
 16-38 1.27e-05

prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all examples of the N-terminal region of bacterial proteins that resemble type IV pilins at their N-terminus, with a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue, usually Phe, is methylated. Separate domains of the prepilin peptidase appear responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this N-terminal domain. The N-terminal cleavage and methylation site is described by PROSITE motif PS00409 as [KRHEQSTAG]-G-[FYLIVM]-[ST]-[LT]-[LIVP]-E-[LIVMFWSTAG](14). [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274182 [Multi-domain]  Cd Length: 24  Bit Score: 40.75  E-value: 1.27e-05
                          10        20
                  ....*....|....*....|...
gi 752540763   16 AGFSLIELVIVIVILGILAVTAL 38
Cdd:TIGR02532   2 RGFTLIELLVVLAILGILALIAL 24
PilV COG4967
Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];
7-38 1.52e-03

Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];


Pssm-ID: 443993 [Multi-domain]  Cd Length: 86  Bit Score: 36.50  E-value: 1.52e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 752540763   7 RPVRALGRMAGFSLIELVIVIVIL--GILAVTAL 38
Cdd:COG4967    2 SRRRRRRRQRGFTLIEVLVALVILsiGLLGLAGL 35
PulJ COG4795
Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and ...
 10-43 1.95e-03

Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443823 [Multi-domain]  Cd Length: 118  Bit Score: 36.92  E-value: 1.95e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 752540763  10 RALGRMAGFSLIELVIVIVILGILAVTALpRFLD 43
Cdd:COG4795    3 RARRRQRGFTLLELLVALAIFALLLLAAY-RGLD 35
PRK10574 PRK10574
putative major pilin subunit; Provisional
 17-39 6.71e-03

putative major pilin subunit; Provisional


Pssm-ID: 236718 [Multi-domain]  Cd Length: 146  Bit Score: 35.78  E-value: 6.71e-03
                         10        20
                 ....*....|....*....|...
gi 752540763  17 GFSLIELVIVIVILGILAVTALP 39
Cdd:PRK10574   6 GFTLIELMVVIAIIAILSAIGIP 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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